Insulin receptor signaling pathway module

A compact insulin receptor signaling module. Insulin binding activates the receptor tyrosine kinase INSR, which autophosphorylates and phosphorylates IRS adaptors. IRS phosphotyrosines recruit PI3K and route the signal into PIP3-AKT signaling, controlling FOXO-dependent transcription, glucose uptake, glycogen metabolism, growth, and survival. The module is grounded in GO:0008286 and uses PAINT PTN anchors for the insulin receptor and AKT-family signaling roles where local IBD seed rows support them.

MODULE:insulin_receptor_signalingDRAFTSignaling Pathwaymodules/insulin_receptor_signaling.yaml
insulin receptor signaling pathwayGO:0008286
GO:0008286
insulin receptor signaling pathway
The module is grounded in the GO biological process term for insulin receptor signaling.
4Nodes
3Parts
0Variant Sets
0Variants
5Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:insulin_receptor_signaling deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/5 grounded genes reviewed)

0 complete review(s) · 1 with deep research · 4 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
FOXO1 Q12778 ✓ 145/148 ✓
INSR P06213 ✗ — —
PIK3R1 P27986 ✗ — —
AKT2 P31751 ✗ — —
IRS1 P35568 ✗ — —

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
Insulin receptor signaling pathwaySignaling Pathwayinsulin_receptor_signaling
insulin receptor signaling pathwayGO:0008286
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

INSR phosphorylates IRS adaptors.
PI3K recruitment and PIP3 production activate AKT-dependent output.
Part 1: insulin receptor activation
Insulin-bound receptor tyrosine kinase activationReactioninsulin_receptor_activation

Insulin binding stabilizes the active receptor dimer, enabling activation-loop autophosphorylation and phosphorylation of adaptor substrates.

Annotons

Insulin receptor kinase
insulin_receptor
Participant: Family: insulin receptor / receptor tyrosine kinase family
Family:
insulin receptor / receptor tyrosine kinase familyPANTHER:PTHR24416
Representative Members: INSRUniProtKB:P06213

Function

insulin receptor activityGO:0005009

Processes

insulin receptor signaling pathwayGO:0008286

Ligand-activated receptor tyrosine kinase at the head of the pathway.

Part 2: IRS docking and PI3K recruitment
IRS phosphotyrosine docking recruits PI3KRegulatory Stepirs_pi3k_recruitment

IRS proteins are phosphorylated by INSR and provide SH2 docking sites for PI3K regulatory subunits, routing the signal into the PI3K-AKT arm.

Annotons

IRS adaptor
irs_adaptor
Participant: Gene Product: IRS1
Gene Product:
IRS1UniProtKB:P35568

Receptor-phosphorylated adaptor that recruits SH2-domain effectors.

PI3K p85 regulatory subunit
pi3k_regulatory_subunit
Participant: Gene Product: PIK3R1
Gene Product:
PIK3R1UniProtKB:P27986

SH2-domain regulatory subunit that links IRS phosphotyrosines to PI3K activation.

Part 3: AKT and FOXO output
AKT activation and FOXO inhibitionRegulatory Stepakt_foxo_output

PI3K-generated PIP3 activates AKT, which phosphorylates FOXO transcription factors and other metabolic/growth substrates.

Annotons

AKT effector kinase
akt_effector
Participant: Family: AKT/PKB serine-threonine kinases
Family:
AKT/PKB serine-threonine kinasesPANTHER:PTHR24351
Representative Members: AKT2UniProtKB:P31751

Function

protein serine/threonine kinase activityGO:0004674
Targets: FOXO transcription factors

Major kinase output linking insulin receptor activation to metabolism and growth.

FOXO transcriptional effector
foxo_output
Participant: Family: FOXO transcription factors
Family:
FOXO transcription factorsPANTHER:PTHR45767
Representative Members: FOXO1UniProtKB:Q12778

Locations

nucleusGO:0005634

AKT-regulated transcription factor family controlling fasting and stress-response genes.