A compact integrin signaling module. Extracellular-matrix engagement clusters integrins, talin/kindlin link cytoplasmic integrin tails to actin, FAK/PTK2 and SRC-family kinases are recruited and activated at focal adhesions, and adaptor scaffolds such as paxillin route the signal to Rho GTPase, MAPK, PI3K, migration, survival, and mechanotransduction outputs. The module is grounded in GO:0007229 and includes PAINT PTN anchors for the FAK/SRC tyrosine kinase tier where local IBD rows support the role.
All recommended fields populated.
✗ none found
No MODULE:integrin_fak_src_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
2 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| fak_kinase | PTK2 UniProtKB:Q05397 Family Representative |
non-membrane spanning protein tyrosine kinase activity GO:0004715 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| src_kinase | SRC UniProtKB:P12931 Family Representative |
protein tyrosine kinase activity GO:0004713 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| fak_kinase | focal adhesion kinase / non-receptor tyrosine kinases PANTHER:PTHR24418 Family |
non-membrane spanning protein tyrosine kinase activity GO:0004715 |
Family Review Missing
No supported structured family review is available for PANTHER:PTHR24418. |
| src_kinase | SRC-family non-receptor tyrosine kinases PANTHER:PTHR24418 Family |
protein tyrosine kinase activity GO:0004713 |
Family Review Missing
No supported structured family review is available for PANTHER:PTHR24418. |
1 complete review(s) · 0 with deep research · 1 missing review · 4 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| ITGB1 P05556 | ✓ | 347/349 | ✗ |
| PXN P49023 | ✗ | — | — |
| PTK2 Q05397 | ✓ | 229/234 | ✗ |
| SRC P12931 | ✓ | 550/551 | ✗ |
| TLN1 Q9Y490 | ✓ | ✓ | ✗ |
Extracellular-matrix ligand engagement and cytoplasmic talin binding cluster integrins and mechanically link them to the actin cytoskeleton.
Integrin receptor subunit exemplar for ECM-triggered signaling.
Integrin-tail and actin-binding adaptor that promotes integrin activation and force coupling.
Integrin clustering recruits FAK and SRC-family kinases to focal adhesions, enabling mutual activation.
Focal-adhesion kinase scaffold/catalyst activated after integrin engagement.
Partner kinase that phosphorylates focal-adhesion substrates and signaling adaptors.
Phosphorylated focal-adhesion adaptors recruit effectors for motility, survival, and mechanotransduction.
Phosphotyrosine scaffold organizing focal-adhesion downstream branches.