Mitochondrial protein import machinery

Nearly all mitochondrial proteins are made in the cytosol and imported. This module is the eukaryote-wide core of that machinery, written so that it can be evaluated in any genome: the Tom40 outer-membrane pore through which most precursors enter; the Sam50 beta-barrel insertase; the TIM23 presequence translocase with its Hsp70-based import motor; the TIM22 carrier insertase; the intermembrane-space disulfide relay; and the mitochondrial processing peptidase that removes presequences. Optional parts are components missing from some eukaryotic lineages: receptors that PAINT places only in opisthokonts, and Mia40, which kinetoplastids lack.

MODULE:mitochondrial_protein_importDRAFTCONCRETEBiological Processmodules/mitochondrial_protein_import.yaml
mitochondrial protein import pathwayGO:7770058
file:projects/MITOCHONDRIAL_IMPORT_PATHWAYS.md
Mitochondrial Import Pathways Project
Route structure (TOM-TIM23-PAM, TIM22, SAM, MIA) and the reviewed human import machinery used as representative members.

Eukaryote-wide scope comes from PAINT: the IBD nodes for Tom40, Sam50, Tim23, Tim17, Tim22, Tim44, Pam16, Pam18, Mge1, Mia40, Erv1 and MPP beta are placed at Eukaryota (taxon:2759), whereas Tom22 and Tom70 are placed at Opisthokonta, so the receptors are optional. Read as a satisfiability rule, every non-optional part is expected in any eukaryote with a mitochondrion-related organelle, except in the lineages named below, which are not yet modelled as variants and so will be reported as import gaps rather than passes. Known exceptions: kinetoplastids replace the TIM23/TIM22 pair with a single Tim17-family translocase and lack Mia40, and plant and kinetoplastid outer-membrane receptors (TOM20-like, ATOM) are not homologous to the opisthokont ones. Mia40 is therefore optional within the disulfide relay. The mtHsp70 motor is grounded only at the whole Hsp70 family; a mitochondrial-subfamily selector is needed before that step discriminates in a genome. The Pam18 selector (PTHR12763) likewise also matches the paralogous DNAJC15/MCJ subfamily (PTHR12763:SF7). Not yet modelled: alpha-helical outer-membrane insertion (MIM/MTCH), TIM23-SORT lateral release, the Tim50 presequence receptor (its PANTHER family PTHR12210 is the broad FCP1-like phosphatase family, so it needs a subfamily selector), and the small Tim chaperones of the TIM22 route. The Drosophila compendium dmel_mitochondrial_protein_import models the same stage, including Tim50 and the small Tims, and is a source for extending this rule.

10Nodes
9Parts
0Variant Sets
0Variants
16Annotons
6Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:mitochondrial_protein_import deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Reaction chaining (advisory)

✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.

  • tom_translocation → tim23_translocation [NOT_CHECKED]
  • tim23_translocation → pam_motor [NOT_CHECKED]
  • pam_motor → mpp_processing [NOT_CHECKED]
  • tom_translocation → sam_insertion [NOT_CHECKED]
  • tom_translocation → tim22_insertion [NOT_CHECKED]
  • tom_translocation → mia_relay [NOT_CHECKED]

Function consistency and core coverage

15 gene-function check(s) reflected in core functions · 0 conflict(s) · 17 evidence or coverage gap(s) (32 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
tom40_channel TOMM40 (human)
UniProtKB:O96008
Family Representative 		transmembrane protein transporter activity
GO:0008320 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
tom22_receptor TOMM22 (human)
UniProtKB:Q9NS69
Family Representative 		mitochondrial signal sequence receptor activity
GO:0140436 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
tom70_receptor TOMM70 (human)
UniProtKB:O94826
Family Representative 		protein-macromolecule adaptor activity
GO:0030674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
sam50_insertase SAMM50 (human)
UniProtKB:Q9Y512
Family Representative 		membrane insertase activity
GO:0032977 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
tim23_channel TIMM23 (human)
UniProtKB:O14925
Family Representative 		transmembrane protein transporter activity
GO:0008320 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
tim17_subunit TIMM17A (human)
UniProtKB:Q99595
Family Representative 		transmembrane protein transporter activity
GO:0008320 		Annotation Supported
A retained annotation or curated replacement supports this function, but core_functions does not yet reflect it.
tim44_tether TIMM44 (human)
UniProtKB:O43615
Family Representative 		protein-macromolecule adaptor activity
GO:0030674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
pam16_regulator PAM16 (human)
UniProtKB:Q9Y3D7
Family Representative 		protein-macromolecule adaptor activity
GO:0030674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
pam18_j_protein DNAJC19 (human)
UniProtKB:Q96DA6
Family Representative 		ATPase activator activity
GO:0001671 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
mthsp70_motor HSPA9 (human)
UniProtKB:P38646
Family Representative 		ATP hydrolysis activity
GO:0016887 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
mge1_exchange_factor GRPEL1 (human)
UniProtKB:Q9HAV7
Family Representative 		adenyl-nucleotide exchange factor activity
GO:0000774 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
tim22_insertase TIMM22 (human)
UniProtKB:Q9Y584
Family Representative 		membrane insertase activity
GO:0032977 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
erv1_oxidase GFER (human)
UniProtKB:P55789
Family Representative 		flavin-dependent sulfhydryl oxidase activity
GO:0016971 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
mia40_oxidoreductase CHCHD4 (human)
UniProtKB:Q8N4Q1
Family Representative 		disulfide oxidoreductase activity
GO:0015036 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
mpp_beta_peptidase PMPCB (human)
UniProtKB:O75439
Family Representative 		metalloendopeptidase activity
GO:0004222 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
mpp_alpha_subunit PMPCA (human)
UniProtKB:Q10713
Family Representative 		protein-macromolecule adaptor activity
GO:0030674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
tom40_channel Tom40 family
PANTHER:PTHR10802
Family 		transmembrane protein transporter activity
GO:0008320 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR10802.
tom22_receptor Tom22 family
PANTHER:PTHR12504
Family 		mitochondrial signal sequence receptor activity
GO:0140436 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR12504.
tom70_receptor Tom70 family
PANTHER:PTHR46208
Family 		protein-macromolecule adaptor activity
GO:0030674 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR46208.
sam50_insertase Sam50/Omp85 family
PANTHER:PTHR12815
Family 		membrane insertase activity
GO:0032977 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR12815.
tim23_channel Tim23 family
PANTHER:PTHR15371
Family 		transmembrane protein transporter activity
GO:0008320 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR15371.
tim17_subunit Tim17 family
PANTHER:PTHR10485
Family 		transmembrane protein transporter activity
GO:0008320 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR10485.
tim44_tether Tim44 family
PANTHER:PTHR10721
Family 		protein-macromolecule adaptor activity
GO:0030674 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR10721.
pam16_regulator Pam16 family
PANTHER:PTHR12388
Family 		protein-macromolecule adaptor activity
GO:0030674 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR12388.
pam18_j_protein Pam18/DNAJC19 J-protein family
PANTHER:PTHR12763
Family 		ATPase activator activity
GO:0001671 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR12763.
mthsp70_motor Hsp70 family
PANTHER:PTHR19375
Family 		ATP hydrolysis activity
GO:0016887 		Family Function Unreviewed
The family review has no applicable adjudication supporting or excluding GO:0016887.
mge1_exchange_factor GrpE/Mge1 family
PANTHER:PTHR21237
Family 		adenyl-nucleotide exchange factor activity
GO:0000774 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR21237.
tim22_insertase Tim22 family
PANTHER:PTHR14110
Family 		membrane insertase activity
GO:0032977 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR14110.
erv1_oxidase Erv/ALR family
PANTHER:PTHR12645
Family 		flavin-dependent sulfhydryl oxidase activity
GO:0016971 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR12645.
mia40_oxidoreductase Mia40/CHCHD4 family
PANTHER:PTHR21622
Family 		disulfide oxidoreductase activity
GO:0015036 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR21622.
mpp_beta_peptidase MPP beta subfamily
PANTHER:PTHR11851:SF103
Family 		metalloendopeptidase activity
GO:0004222 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR11851:SF103.
mpp_alpha_subunit MPP alpha subfamily
PANTHER:PTHR11851:SF192
Family 		protein-macromolecule adaptor activity
GO:0030674 		Family Review Missing
No supported structured family review is available for PANTHER:PTHR11851:SF192.

Gene-review completeness (16/16 grounded genes reviewed)

15 complete review(s) · 15 with deep research · 0 missing review · 1 reviewed but lacking deep research

Gene Review Complete Deep research
CHCHD4 Q8N4Q1 ✓ ✓ ✓
DNAJC19 Q96DA6 ✓ ✓ ✗
GFER P55789 ✓ 25/27 ✓
GRPEL1 Q9HAV7 ✓ ✓ ✓
HSPA9 P38646 ✓ ✓ ✓
PAM16 Q9Y3D7 ✓ ✓ ✓
PMPCA Q10713 ✓ ✓ ✓
PMPCB O75439 ✓ ✓ ✓
SAMM50 Q9Y512 ✓ ✓ ✓
TIMM17A Q99595 ✓ ✓ ✓
TIMM22 Q9Y584 ✓ ✓ ✓
TIMM23 O14925 ✓ ✓ ✓
TIMM44 O43615 ✓ ✓ ✓
TOMM22 Q9NS69 ✓ ✓ ✓
TOMM40 O96008 ✓ ✓ ✓
TOMM70 O94826 ✓ ✓ ✓

Details

Context
EukaryotaNCBITaxon:2759
Mitochondrial protein import machineryBiological Processmitochondrial_protein_import
mitochondrial protein import pathwayGO:7770058
Context
EukaryotaNCBITaxon:2759

Connections

Part 1: outer membrane entry
TOM outer-membrane translocationTransport Steptom_translocation

Entry route through the outer membrane shared by matrix, inner-membrane and intermembrane-space precursors.

mitochondrial outer membrane translocase complexGO:0005742

Annotons

Tom40 beta-barrel general import pore
tom40_channel
Participant: Family: Tom40 family
Family:
Tom40 familyPANTHER:PTHR10802
Representative Members: TOMM40 (human)UniProtKB:O96008

Function

transmembrane protein transporter activityGO:0008320

Locations

mitochondrial outer membraneGO:0005741

Forms the outer-membrane pore through which nearly all nuclear-encoded mitochondrial precursors enter.

file:genes/human/TOMM40/TOMM40-ai-review.yaml
Reviewed core function of human TOMM40: transmembrane protein transporter activity.
file:interpro/panther/PTHR10802/PTHR10802-paint.tsv
PAINT placement of the Tom40 family at Eukaryota.
Part 1: opisthokont TOM receptors (optional)
Tom22/Tom70 receptors (Opisthokonta)Transport Stepopisthokont_tom_receptors
Context
OpisthokontaNCBITaxon:33154

Annotons

Tom22 central presequence receptor
tom22_receptor
Participant: Family: Tom22 family
Family:
Tom22 familyPANTHER:PTHR12504 PAINT places the Tom22 IBD node (PTN004364609) at Opisthokonta (taxon:33154), not Eukaryota.
Representative Members: TOMM22 (human)UniProtKB:Q9NS69

Function

mitochondrial signal sequence receptor activityGO:0140436

Locations

mitochondrial outer membraneGO:0005741

Receives presequence-carrying precursors at the TOM complex and hands them to the Tom40 pore.

file:genes/human/TOMM22/TOMM22-ai-review.yaml
Reviewed core function of human TOMM22: mitochondrial signal sequence receptor activity.
file:interpro/panther/PTHR12504/PTHR12504-paint.tsv
PANTHER family PTHR12504 classification of human TOMM22.
Tom70 internal-signal (carrier) receptor
tom70_receptor
Participant: Family: Tom70 family
Family:
Tom70 familyPANTHER:PTHR46208 PAINT places the Tom70 IBD node (PTN002340064) at Opisthokonta (taxon:33154), not Eukaryota.
Representative Members: TOMM70 (human)UniProtKB:O94826

Function

protein-macromolecule adaptor activityGO:0030674

Locations

mitochondrial outer membraneGO:0005741

Docks chaperone-bound hydrophobic precursors, notably inner-membrane carriers, at the TOM complex.

file:genes/human/TOMM70/TOMM70-ai-review.yaml
Reviewed core function of human TOMM70: protein-macromolecule adaptor activity.
file:interpro/panther/PTHR46208/PTHR46208-paint.tsv
PANTHER family PTHR46208 classification of human TOMM70.
Part 2: beta-barrel insertion
SAM beta-barrel insertionTransport Stepsam_insertion
beta barrel protein insertion into mitochondrial outer membraneGO:7770063

Annotons

Sam50 beta-barrel insertase
sam50_insertase
Participant: Family: Sam50/Omp85 family
Family:
Sam50/Omp85 familyPANTHER:PTHR12815
Representative Members: SAMM50 (human)UniProtKB:Q9Y512

Function

membrane insertase activityGO:0032977

Locations

mitochondrial outer membraneGO:0005741

Folds and inserts beta-barrel precursors, including Tom40 itself, into the outer membrane.

file:genes/human/SAMM50/SAMM50-ai-review.yaml
Reviewed core function of human SAMM50: membrane insertase activity.
file:interpro/panther/PTHR12815/PTHR12815-paint.tsv
PAINT placement of the Sam50/Omp85 family at Eukaryota.
Part 3: presequence translocation
TIM23 presequence translocationTransport Steptim23_translocation
TIM23 mitochondrial import inner membrane translocase complexGO:0005744

Annotons

Tim23 presequence channel
tim23_channel
Participant: Family: Tim23 family
Family:
Tim23 familyPANTHER:PTHR15371
Representative Members: TIMM23 (human)UniProtKB:O14925

Function

transmembrane protein transporter activityGO:0008320

Locations

mitochondrial inner membraneGO:0005743

Forms the inner-membrane channel for presequence-carrying precursors.

file:genes/human/TIMM23/TIMM23-ai-review.yaml
Reviewed core function of human TIMM23: transmembrane protein transporter activity.
file:interpro/panther/PTHR15371/PTHR15371-paint.tsv
PAINT placement of the Tim23 family at Eukaryota.
Tim17 presequence translocase subunit
tim17_subunit
Participant: Family: Tim17 family
Family:
Tim17 familyPANTHER:PTHR10485
Representative Members: TIMM17A (human)UniProtKB:Q99595

Function

transmembrane protein transporter activityGO:0008320

Locations

mitochondrial inner membraneGO:0005743

Core subunit of the TIM23 translocase that, with Tim23, conducts presequence precursors across the inner membrane.

file:genes/human/TIMM17A/TIMM17A-ai-review.yaml
Reviewed core function of human TIMM17A: transmembrane protein transporter activity.
file:interpro/panther/PTHR10485/PTHR10485-paint.tsv
PAINT placement of the Tim17 family at Eukaryota.
Part 4: matrix import motor
PAM Hsp70 import motorTransport Steppam_motor
PAM complex, Tim23 associated import motorGO:0001405

Annotons

Tim44 motor tether
tim44_tether
Participant: Family: Tim44 family
Family:
Tim44 familyPANTHER:PTHR10721
Representative Members: TIMM44 (human)UniProtKB:O43615

Function

protein-macromolecule adaptor activityGO:0030674

Locations

mitochondrial inner membraneGO:0005743

Tethers mtHsp70 to the TIM23 channel exit so the motor can pull precursors into the matrix.

file:genes/human/TIMM44/TIMM44-ai-review.yaml
Reviewed core function of human TIMM44: protein-macromolecule adaptor activity.
file:interpro/panther/PTHR10721/PTHR10721-paint.tsv
PAINT placement of the Tim44 family at Eukaryota.
Pam16 J-like motor regulator
pam16_regulator
Participant: Family: Pam16 family
Family:
Pam16 familyPANTHER:PTHR12388
Representative Members: PAM16 (human)UniProtKB:Q9Y3D7

Function

protein-macromolecule adaptor activityGO:0030674

Locations

mitochondrial inner membraneGO:0005743

Positions and regulates the J-protein that stimulates mtHsp70 ATPase at the import motor.

file:genes/human/PAM16/PAM16-ai-review.yaml
Reviewed core function of human PAM16: protein-macromolecule adaptor activity.
file:interpro/panther/PTHR12388/PTHR12388-paint.tsv
PAINT placement of the Pam16 family at Eukaryota.
Pam18 J-protein ATPase activator
pam18_j_protein
Participant: Family: Pam18/DNAJC19 J-protein family
Family:
Pam18/DNAJC19 J-protein familyPANTHER:PTHR12763
Representative Members: DNAJC19 (human)UniProtKB:Q96DA6

Function

ATPase activator activityGO:0001671

Locations

mitochondrial inner membraneGO:0005743

J-domain partner of Pam16 that stimulates the mtHsp70 ATPase, coupling ATP hydrolysis to precursor capture.

file:genes/human/DNAJC19/DNAJC19-ai-review.yaml
Reviewed core function of human DNAJC19: ATPase activator activity.
file:interpro/panther/PTHR12763/PTHR12763-paint.tsv
PAINT placement of the Pam18/DNAJC19 J-protein family at Eukaryota.
Mitochondrial Hsp70 import motor ATPase
mthsp70_motor
Participant: Family: Hsp70 family
Family:
Hsp70 familyPANTHER:PTHR19375 The PANTHER family is the whole Hsp70 family and no mitochondrial subfamily is recorded locally, so this family selector over-matches cytosolic and ER Hsp70s when the module is evaluated in a genome. PAINT node PTN000452554 marks the eukaryote-wide mitochondrial Hsp70 clade (it grounds the same protein in MODULE:mitochondrial_iron_sulfur_cluster_assembly) but is not part of the selector.
Representative Members: HSPA9 (human)UniProtKB:P38646

Function

ATP hydrolysis activityGO:0016887

Locations

mitochondrial matrixGO:0005759

ATP-driven matrix motor that binds incoming precursor and drives its translocation into the matrix.

file:genes/human/HSPA9/HSPA9-ai-review.yaml
Reviewed core function of human HSPA9: ATP hydrolysis activity.
file:interpro/panther/PTHR19375/PTHR19375-paint.tsv
PANTHER family PTHR19375 classification of human HSPA9.
Mge1 nucleotide exchange factor
mge1_exchange_factor
Participant: Family: GrpE/Mge1 family
Family:
GrpE/Mge1 familyPANTHER:PTHR21237
Representative Members: GRPEL1 (human)UniProtKB:Q9HAV7

Function

adenyl-nucleotide exchange factor activityGO:0000774

Locations

mitochondrial matrixGO:0005759

Releases ADP from mtHsp70 so the import motor can start a new ATPase cycle.

file:genes/human/GRPEL1/GRPEL1-ai-review.yaml
Reviewed core function of human GRPEL1: adenyl-nucleotide exchange factor activity.
file:interpro/panther/PTHR21237/PTHR21237-paint.tsv
PAINT placement of the GrpE/Mge1 family at Eukaryota.
Part 5: carrier insertion
TIM22 carrier insertionTransport Steptim22_insertion
TOM-TIM22-mediated mitochondrial inner membrane protein insertionGO:7770061

Annotons

Tim22 carrier insertase
tim22_insertase
Participant: Family: Tim22 family
Family:
Tim22 familyPANTHER:PTHR14110
Representative Members: TIMM22 (human)UniProtKB:Q9Y584

Function

membrane insertase activityGO:0032977

Locations

mitochondrial inner membraneGO:0005743

Inserts multispanning carrier-family precursors laterally into the inner membrane.

file:genes/human/TIMM22/TIMM22-ai-review.yaml
Reviewed core function of human TIMM22: membrane insertase activity.
file:interpro/panther/PTHR14110/PTHR14110-paint.tsv
PAINT placement of the Tim22 family at Eukaryota.
Part 6: intermembrane-space disulfide relay
MIA disulfide relayTransport Stepmia_relay
protein import into the intermembrane space via the disulfide relay systemGO:0160203

Annotons

Erv1/ALR sulfhydryl oxidase
erv1_oxidase
Participant: Family: Erv/ALR family
Family:
Erv/ALR familyPANTHER:PTHR12645
Representative Members: GFER (human)UniProtKB:P55789

Function

flavin-dependent sulfhydryl oxidase activityGO:0016971

Locations

mitochondrial intermembrane spaceGO:0005758

Reoxidizes the relay oxidoreductase, passing electrons on toward cytochrome c, so oxidative folding can trap precursors in the intermembrane space.

file:genes/human/GFER/GFER-ai-review.yaml
Reviewed core function of human GFER: flavin-dependent sulfhydryl oxidase activity.
file:interpro/panther/PTHR12645/PTHR12645-paint.tsv
PAINT placement of the Erv/ALR family at Eukaryota.
Part 1: Mia40 receptor-oxidoreductase (optional)
Mia40 oxidoreductaseReactionmia40_step

Annotons

Mia40 intermembrane-space import receptor and oxidoreductase
mia40_oxidoreductase
Participant: Family: Mia40/CHCHD4 family
Family:
Mia40/CHCHD4 familyPANTHER:PTHR21622
Representative Members: CHCHD4 (human)UniProtKB:Q8N4Q1

Function

disulfide oxidoreductase activityGO:0015036

Locations

mitochondrial intermembrane spaceGO:0005758

Captures cysteine-motif precursors entering the intermembrane space and introduces their disulfides.

file:genes/human/CHCHD4/CHCHD4-ai-review.yaml
Reviewed core function of human CHCHD4: disulfide oxidoreductase activity.
file:interpro/panther/PTHR21622/PTHR21622-paint.tsv
PAINT placement of the Mia40/CHCHD4 family at Eukaryota.
Part 7: presequence processing
MPP presequence cleavageReactionmpp_processing
mitochondrial protein processingGO:0034982

Annotons

Mitochondrial processing peptidase beta (catalytic)
mpp_beta_peptidase
Participant: Family: MPP beta subfamily
Family:
MPP beta subfamilyPANTHER:PTHR11851:SF103
Representative Members: PMPCB (human)UniProtKB:O75439

Function

metalloendopeptidase activityGO:0004222

Locations

mitochondrial matrixGO:0005759

Catalytic subunit that cleaves matrix-targeting presequences from imported precursors.

file:genes/human/PMPCB/PMPCB-ai-review.yaml
Reviewed core function of human PMPCB: metalloendopeptidase activity.
file:interpro/panther/PTHR11851/PTHR11851-paint.tsv
PAINT placement of the MPP beta subfamily at Eukaryota.
Mitochondrial processing peptidase alpha (substrate binding)
mpp_alpha_subunit
Participant: Family: MPP alpha subfamily
Family:
MPP alpha subfamilyPANTHER:PTHR11851:SF192
Representative Members: PMPCA (human)UniProtKB:Q10713

Function

protein-macromolecule adaptor activityGO:0030674

Locations

mitochondrial matrixGO:0005759

Non-catalytic partner that binds presequences and presents them to the beta subunit.

file:genes/human/PMPCA/PMPCA-ai-review.yaml
Reviewed core function of human PMPCA: protein-macromolecule adaptor activity.
file:interpro/panther/PTHR11851/PTHR11851-paint.tsv
PANTHER family PTHR11851 classification of human PMPCA.