Function
Processes
Supplies iminoaspartate to quinolinate synthase.
A reusable, scope-limited route set for organisms that use the L-aspartate de novo pathway and/or selected nicotinate, nicotinamide, and NMN salvage alternatives. Every realization is end-to-end: NaMN made by L-aspartate de novo synthesis, PncB, or PncC must pass through deamido-NAD to NAD+, whereas NMN made by NAMPT must be adenylylated directly to NAD+. Alternative adenylyltransferase families and NAD synthetase nitrogen donors are modeled as variants. This is not a universal NAD+ biosynthesis hub: de novo synthesis through L-tryptophan and the kynurenine pathway is owned by the existing MODULE:kynurenine_nad_de_novo module and is not duplicated here. Nicotinate degradation, pyridine-nucleotide transhydrogenases, NAD kinase and NADP formation, NAD-consuming reactions, and unrelated aldehyde metabolism are outside the boundary.
The root requires one or more complete route classes; no empty realization is valid. All NaMN-producing alternatives are connected only to required NaMN adenylylation and deamido-NAD amidation, and NAMPT-produced NMN is connected only to required direct NMN adenylylation. PncA and PncC remain distinct: PncA deamidates nicotinamide to nicotinate, whereas PncC deamidates NMN to NaMN. The module deliberately ends at NAD+ and excludes kynurenine-route duplication, NADP formation, and NAD+ consumption. The KT2440-specific PP_3298 gap below is realization-level curation metadata; it neither changes the reusable route logic nor adds an obligatory family.
references[0] · findings
(0/1)references[1] · findings
(0/1)✓ present
1 leaf node(s) with no concrete protein grounding:
✓ every declared conforms_to bundle matches its template motif.
10 complete review(s) · 7 with deep research · 8 missing review · 3 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| nadA Q88NH8 | ✓ | ✓ | ✓ |
| nadB Q88MZ2 | ✓ | ✓ | ✓ |
| nadC Q88PR1 | ✓ | ✓ | ✓ |
| nadD Q88DL5 | ✓ | ✓ | ✓ |
| nadE Q88DF6 | ✓ | ✓ | ✓ |
| NADSYN1 Q6IA69 | ✓ | ✓ | ✗ |
| NAMPT P43490 | ✓ | ✓ | ✗ |
| NMNAT1 Q9HAN9 | ✓ | ✓ | ✗ |
| Escherichia coli PncC P0A6G3 | ✗ | — | — |
| Escherichia coli NadD P0A752 | ✗ | — | — |
| Escherichia coli NadB P10902 | ✗ | — | — |
| Escherichia coli NadA P11458 | ✗ | — | — |
| Escherichia coli PncB P18133 | ✗ | — | — |
| Escherichia coli NadE P18843 | ✗ | — | — |
| Escherichia coli PncA P21369 | ✗ | — | — |
| Escherichia coli NadC P30011 | ✗ | — | — |
| pncB Q88DF7 | ✓ | ✓ | ✓ |
| pncC Q88ME5 | ✓ | ✓ | ✓ |
At least one complete route class must be selected. Neither class contains an empty or optional completion path.
A complete realization selects one or more NaMN-producing alternatives and must then convert NaMN through deamido-NAD to NAD+.
Each alternative in this node ends in nicotinate D-ribonucleotide (NaMN). The selected alternative must therefore continue through NaMN adenylylation and deamido-NAD amidation rather than through direct NMN completion.
The conserved bacterial route oxidizes L-aspartate to iminoaspartate, condenses that unstable intermediate with glycerone phosphate to form quinolinate, and phosphoribosylates quinolinate to NaMN.
Supplies iminoaspartate to quinolinate synthase.
Produces quinolinate for phosphoribosylation.
Produces NaMN, the entry to shared completion.
Converts available nicotinate directly to NaMN.
Makes nicotinate available to PncB.
Converts PncA-derived nicotinate to NaMN.
Routes NMN into the shared NaMN completion branch.
A complete amidated salvage realization preserves the nicotinamide amide in NMN and requires direct NMN adenylylation to NAD+.
Preserves the amide while producing NMN for direct completion.
NMN adenylyltransferase preserves the carboxamide and converts NMN directly to NAD+, bypassing deamido-NAD and NAD synthetase.
Completes amidated NMN salvage without a separate amidation step.