Neurotrophin TRK receptor signaling pathway module

Neurotrophins activate TRK receptor tyrosine kinases, engaging Ras-MAPK, PI3K-AKT, and PLC-gamma branches that regulate neuronal survival, differentiation, and plasticity.

MODULE:neurotrophin_trk_signalingDRAFTSignaling Pathwaymodules/neurotrophin_trk_signaling.yaml
neurotrophin TRK receptor signaling pathwayGO:0048011
file:modules/neurotrophin_trk_signaling-deep-research-falcon.md
Neurotrophin TRK receptor signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0048011
neurotrophin TRK receptor signaling pathway
The module is grounded in the GO biological process term for neurotrophin TRK receptor signaling pathway.
PANTHER:PTN001230349
PAINT node PTN001230349 for NTRK1
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0005886, C:GO:0043235, F:GO:0004714, P:GO:0007169; PAINT date 20260529.
PANTHER:PTN001230900
PAINT node PTN001230900 for NTRK1
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0005030, P:GO:1990090; PAINT date 20170830.
PANTHER:PTN002814914
PAINT node PTN002814914 for NTRK2
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0060175; PAINT date 20200401.
PANTHER:PTN002814940
PAINT node PTN002814940 for NTRK1
Local PAINT IBD node in PTHR24416 with propagated terms P:GO:0038180; PAINT date 20200930.
PANTHER:PTN005273574
PAINT node PTN005273574 for GRB2
Local PAINT IBD node in PTHR46037 with propagated terms C:GO:0005737, C:GO:0005886, C:GO:0008180, F:GO:0001784, F:GO:0005154, P:GO:0007165; PAINT date 20260530.
PANTHER:PTN008302071
PAINT node PTN008302071 for PIK3R1
Local PAINT IBD node in PTHR10155 with propagated terms C:GO:0005943; PAINT date 20240516.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
8Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • neurotrophin_trk_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (0/6 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 6 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
NGF P01138 ✗ — —
NTRK1 P04629 ✗ — —
BDNF P23560 ✗ — —
PIK3R1 P27986 ✗ — —
GRB2 P62993 ✗ — —
NTRK2 Q16620 ✗ — —

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
Neurotrophin TRK receptor signaling pathwaySignaling Pathwayneurotrophin_trk_signaling
neurotrophin TRK receptor signaling pathwayGO:0048011
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes trk adaptor recruitment.
TRK adaptor recruitment leads to neuronal survival output.
Part 1: neurotrophin-trk ligation
Neurotrophin engages TRK receptorRegulatory Stepneurotrophin_engages_trk_receptor

NGF and BDNF exemplify neurotrophin ligands that activate NTRK receptors.

Annotons

NGF ligand
ngf_ngf_ligand
Participant: Gene Product: NGF
Gene Product:
NGFUniProtKB:P01138

Curated exemplar for the ngf ligand role in neurotrophin TRK receptor signaling pathway.

BDNF ligand
bdnf_bdnf_ligand
Participant: Gene Product: BDNF
Gene Product:
BDNFUniProtKB:P23560

Curated exemplar for the bdnf ligand role in neurotrophin TRK receptor signaling pathway.

NTRK1/TRKA receptor
ntrk1_ntrk1_trka_receptor
Participant: Family: NTRK1/TRKA receptor family/ortholog group
Family:
NTRK1/TRKA receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: NTRK1UniProtKB:P04629

Curated exemplar for the ntrk1/trka receptor role in neurotrophin TRK receptor signaling pathway.

NTRK2/TRKB receptor
ntrk2_ntrk2_trkb_receptor
Participant: Family: NTRK2/TRKB receptor family/ortholog group
Family:
NTRK2/TRKB receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: NTRK2UniProtKB:Q16620

Curated exemplar for the ntrk2/trkb receptor role in neurotrophin TRK receptor signaling pathway.

Part 2: trk adaptor recruitment
TRK adaptor recruitmentRegulatory Steptrk_adaptor_recruitment

Activated TRK receptors recruit GRB2/SOS and PI3K adaptors.

Annotons

GRB2 adaptor
grb2_grb2_adaptor
Participant: Family: GRB2 adaptor family/ortholog group
Family:
GRB2 adaptor family/ortholog groupPANTHER:PTHR46037
Representative Members: GRB2UniProtKB:P62993

Curated exemplar for the grb2 adaptor role in neurotrophin TRK receptor signaling pathway.

PI3K p85 adaptor
pik3r1_pi3k_p85_adaptor
Participant: Family: PI3K p85 adaptor family/ortholog group
Family:
PI3K p85 adaptor family/ortholog groupPANTHER:PTHR10155
Representative Members: PIK3R1UniProtKB:P27986

Curated exemplar for the pi3k p85 adaptor role in neurotrophin TRK receptor signaling pathway.

Part 3: neuronal survival output
Neuronal survival and differentiation outputRegulatory Stepneuronal_survival_and_differentiation_output

TRK signaling relays neurotrophin input to survival and differentiation programs.

Annotons

TRKA kinase output
ntrk1_trka_kinase_output
Participant: Family: TRKA kinase output family/ortholog group
Family:
TRKA kinase output family/ortholog groupPANTHER:PTHR24416
Representative Members: NTRK1UniProtKB:P04629

Curated exemplar for the trka kinase output role in neurotrophin TRK receptor signaling pathway.

TRKB kinase output
ntrk2_trkb_kinase_output
Participant: Family: TRKB kinase output family/ortholog group
Family:
TRKB kinase output family/ortholog groupPANTHER:PTHR24416
Representative Members: NTRK2UniProtKB:Q16620

Curated exemplar for the trkb kinase output role in neurotrophin TRK receptor signaling pathway.