PDGFR signaling pathway module

Platelet-derived growth factor ligands activate PDGFR receptor tyrosine kinases, recruiting SH2 adaptors and lipid-kinase branches that control mesenchymal proliferation, migration, and survival.

MODULE:pdgfr_signalingDRAFTSignaling Pathwaymodules/pdgfr_signaling.yaml
platelet-derived growth factor receptor signaling pathwayGO:0048008
file:modules/pdgfr_signaling-deep-research-falcon.md
PDGFR signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0048008
platelet-derived growth factor receptor signaling pathway
The module is grounded in the GO biological process term for platelet-derived growth factor receptor signaling pathway.
PANTHER:PTN000005673
PAINT node PTN000005673 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005737, C:GO:0016020, F:GO:0052742, P:GO:0046854; PAINT date 20260528.
PANTHER:PTN000005674
PAINT node PTN000005674 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005886, F:GO:0016303, F:GO:0035005, P:GO:0043491; PAINT date 20240205.
PANTHER:PTN000799655
PAINT node PTN000799655 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005942; PAINT date 20240516.
PANTHER:PTN000799659
PAINT node PTN000799659 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005943, C:GO:0005944, F:GO:0046934; PAINT date 20240918.
PANTHER:PTN001230349
PAINT node PTN001230349 for PDGFRB
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0005886, F:GO:0004714, P:GO:0007169; PAINT date 20260529.
PANTHER:PTN002814407
PAINT node PTN002814407 for PDGFRB
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0005019, F:GO:0048407, P:GO:0014911, P:GO:0060326; PAINT date 20210610.
PANTHER:PTN004704336
PAINT node PTN004704336 for PDGFRB
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0019838; PAINT date 20240919.
PANTHER:PTN005273574
PAINT node PTN005273574 for GRB2
Local PAINT IBD node in PTHR46037 with propagated terms C:GO:0005737, C:GO:0005886, C:GO:0008180, F:GO:0001784, F:GO:0005154, P:GO:0007165; PAINT date 20260530.
PANTHER:PTN008302071
PAINT node PTN008302071 for PIK3R1
Local PAINT IBD node in PTHR10155 with propagated terms C:GO:0005943; PAINT date 20240516.
PANTHER:PTN008404985
PAINT node PTN008404985 for PDGFRB
Local PAINT IBD node in PTHR24416 with propagated terms P:GO:0008284, P:GO:0016477; PAINT date 20250904.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
6Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • pdgfr_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/5 grounded genes reviewed)

1 complete review(s) · 1 with deep research · 4 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
PDGFRB P09619 ✗ — —
PIK3R1 P27986 ✗ — —
PIK3CG P48736 ✗ — —
GRB2 P62993 ✗ — —
PDGFB P01127 ✓ ✓ ✓

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
PDGFR signaling pathwaySignaling Pathwaypdgfr_signaling
platelet-derived growth factor receptor signaling pathwayGO:0048008
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes phosphotyrosine adaptor assembly.
PDGFR adaptor assembly leads to growth and migration output.
Part 1: pdgf ligand-receptor engagement
PDGF ligand engages PDGFRRegulatory Steppdgf_ligand_engages_pdgfr

PDGFB ligand binding promotes PDGFRB dimerization and kinase activation.

Annotons

PDGFB ligand
pdgfb_pdgfb_ligand
Participant: Gene Product: PDGFB
Gene Product:
PDGFBUniProtKB:P01127

Curated exemplar for the pdgfb ligand role in platelet-derived growth factor receptor signaling pathway.

PDGFRB receptor
pdgfrb_pdgfrb_receptor
Participant: Family: PDGFRB receptor family/ortholog group
Family:
PDGFRB receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: PDGFRBUniProtKB:P09619

Curated exemplar for the pdgfrb receptor role in platelet-derived growth factor receptor signaling pathway.

Part 2: phosphotyrosine adaptor assembly
PDGFR adaptor assemblyRegulatory Steppdgfr_adaptor_assembly

Autophosphorylated PDGFR tails recruit GRB2 and PI3K regulatory adaptors.

Annotons

GRB2 adaptor
grb2_grb2_adaptor
Participant: Family: GRB2 adaptor family/ortholog group
Family:
GRB2 adaptor family/ortholog groupPANTHER:PTHR46037
Representative Members: GRB2UniProtKB:P62993

Curated exemplar for the grb2 adaptor role in platelet-derived growth factor receptor signaling pathway.

PI3K p85 adaptor
pik3r1_pi3k_p85_adaptor
Participant: Family: PI3K p85 adaptor family/ortholog group
Family:
PI3K p85 adaptor family/ortholog groupPANTHER:PTHR10155
Representative Members: PIK3R1UniProtKB:P27986

Curated exemplar for the pi3k p85 adaptor role in platelet-derived growth factor receptor signaling pathway.

Part 3: growth and migration output
PI3K/MAPK motility outputRegulatory Steppi3k_mapk_motility_output

Downstream PI3K and Ras-MAPK branches support survival, proliferation, and cell motility.

Annotons

PI3K catalytic subunit
pik3cg_pi3k_catalytic_subunit
Participant: Family: PI3K catalytic subunit family/ortholog group
Family:
PI3K catalytic subunit family/ortholog groupPANTHER:PTHR10048
Representative Members: PIK3CGUniProtKB:P48736

Curated exemplar for the pi3k catalytic subunit role in platelet-derived growth factor receptor signaling pathway.

PDGFR receptor scaffold
pdgfrb_pdgfr_receptor_scaffold
Participant: Family: PDGFR receptor scaffold family/ortholog group
Family:
PDGFR receptor scaffold family/ortholog groupPANTHER:PTHR24416
Representative Members: PDGFRBUniProtKB:P09619

Curated exemplar for the pdgfr receptor scaffold role in platelet-derived growth factor receptor signaling pathway.