Generic phosphotyrosine-adaptor recruitment motif

The minimal, reusable receptor-proximal recruitment motif: an activated receptor (or receptor-associated kinase) presents a phosphotyrosine docking site; an SH2- or PTB-domain adaptor recognizes that phosphotyrosine; and the adaptor, through a second interaction surface (e.g. an SH3 domain), recruits a downstream effector to the membrane. This pTyr -> adaptor -> effector wiring is the generic interface by which receptor tyrosine kinases, cytokine-receptor- associated JAKs, and other tyrosine-phosphorylation events launch downstream pathways - it is the recruitment step that precedes the Ras switch in MODULE:erk_cascade. The motif is gene-free and taxon-neutral, fixing only the phosphotyrosine-binding and adaptor roles and the recruitment topology. Grounded in GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway).

MODULE:phosphotyrosine_adaptor_recruitmentDRAFTSignaling Pathwaymodules/phosphotyrosine_adaptor_recruitment.yaml
cell surface receptor protein tyrosine kinase signaling pathwayGO:0007169
GO:0007169
cell surface receptor protein tyrosine kinase signaling pathway
The motif is the receptor-proximal adaptor-recruitment step of tyrosine kinase receptor signaling.
GO:0001784
phosphotyrosine residue binding
The defining function of the adaptor step is recognition of the receptor phosphotyrosine.

Reusable conformance target. A node declares `conforms_to: [{template: phosphotyrosine_adaptor_recruitment}]` when a phosphotyrosine docking site recruits an SH2/PTB adaptor that in turn recruits a downstream effector. The specific adaptor (GRB2, SHC, ...) and effector are realization-specific.

4Nodes
3Parts
0Variant Sets
0Variants
3Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:phosphotyrosine_adaptor_recruitment deep-research report alongside the module YAML.

Leaf nodes lacking representative members

3 leaf node(s) with no concrete protein grounding:

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
adaptor_binding_activity ANY_WITH_FUNCTION
Gene 		phosphotyrosine residue binding
GO:0001784 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.
adaptor_function ANY_WITH_FUNCTION
Gene 		protein-macromolecule adaptor activity
GO:0030674 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.

Gene-review completeness (0/0 grounded genes reviewed)

No concrete UniProt-grounded genes in this module.

Details

Phosphotyrosine -> SH2/PTB adaptor -> effector recruitmentSignaling Pathwayphosphotyrosine_adaptor_recruitment
cell surface receptor protein tyrosine kinase signaling pathwayGO:0007169

Connections

receptor_py -> adaptor_binding Provides Input For
The phosphotyrosine docking site is recognized by the adaptor.
The docked adaptor recruits the downstream effector.
Part 1: receptor phosphotyrosine docking site
Activated-receptor phosphotyrosine docking siteRegulatory Stepreceptor_py

An activated receptor or receptor-associated kinase is phosphorylated on tyrosine, creating an SH2/PTB docking site.

Annotons

receptor phosphotyrosine
receptor_py_node
Participant: Any Participant

Presents the phosphotyrosine docking site.

Part 2: SH2/PTB adaptor binding
SH2/PTB adaptor binding to phosphotyrosineReactionadaptor_binding

An SH2- or PTB-domain adaptor recognizes the receptor phosphotyrosine.

Annotons

phosphotyrosine residue binding
adaptor_binding_activity
Participant: Any With Function: phosphotyrosine residue binding
Required Function:
phosphotyrosine residue bindingGO:0001784

Function

phosphotyrosine residue bindingGO:0001784

Docks the adaptor onto the activated receptor.

Part 3: effector recruitment
Adaptor-mediated effector recruitmentRegulatory Stepeffector_recruitment

The bound adaptor recruits a downstream effector via a second interaction surface (e.g. SH3 domain).

Annotons

protein-macromolecule adaptor activity
adaptor_function
Participant: Any With Function: protein-macromolecule adaptor activity
Required Function:
protein-macromolecule adaptor activityGO:0030674

Function

protein-macromolecule adaptor activityGO:0030674
Targets: downstream effector

Bridges the receptor to a downstream effector.