Presents the phosphotyrosine docking site.
Generic phosphotyrosine-adaptor recruitment motif
The minimal, reusable receptor-proximal recruitment motif: an activated receptor (or receptor-associated kinase) presents a phosphotyrosine docking site; an SH2- or PTB-domain adaptor recognizes that phosphotyrosine; and the adaptor, through a second interaction surface (e.g. an SH3 domain), recruits a downstream effector to the membrane. This pTyr -> adaptor -> effector wiring is the generic interface by which receptor tyrosine kinases, cytokine-receptor- associated JAKs, and other tyrosine-phosphorylation events launch downstream pathways - it is the recruitment step that precedes the Ras switch in MODULE:erk_cascade. The motif is gene-free and taxon-neutral, fixing only the phosphotyrosine-binding and adaptor roles and the recruitment topology. Grounded in GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway).
Reusable conformance target. A node declares `conforms_to: [{template: phosphotyrosine_adaptor_recruitment}]` when a phosphotyrosine docking site recruits an SH2/PTB adaptor that in turn recruits a downstream effector. The specific adaptor (GRB2, SHC, ...) and effector are realization-specific.
Derived QC
Recommended-field compliance
All recommended fields populated.
Module deep research
✗ none found
No MODULE:phosphotyrosine_adaptor_recruitment deep-research report alongside the module YAML.
Leaf nodes lacking representative members
3 leaf node(s) with no concrete protein grounding:
- Activated-receptor phosphotyrosine docking site ANY_PARTICIPANT
- SH2/PTB adaptor binding to phosphotyrosine ANY_WITH_FUNCTION
- Adaptor-mediated effector recruitment ANY_WITH_FUNCTION
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Gene-review completeness (0/0 grounded genes reviewed)
No concrete UniProt-grounded genes in this module.
Details
Connections
An activated receptor or receptor-associated kinase is phosphorylated on tyrosine, creating an SH2/PTB docking site.
Annotons
An SH2- or PTB-domain adaptor recognizes the receptor phosphotyrosine.
Annotons
Function
Docks the adaptor onto the activated receptor.
The bound adaptor recruits a downstream effector via a second interaction surface (e.g. SH3 domain).
Annotons
Function
Bridges the receptor to a downstream effector.