Retinoic acid receptor signaling pathway module

Retinoic acid synthesis and transport feed RAR/RXR nuclear receptor complexes that switch chromatin-associated co-repressor/co-activator states to control developmental and differentiation genes.

MODULE:retinoic_acid_receptor_signalingDRAFTSignaling Pathwaymodules/retinoic_acid_receptor_signaling.yaml
retinoic acid receptor signaling pathwayGO:0048384
file:modules/retinoic_acid_receptor_signaling-deep-research-falcon.md
Retinoic acid receptor signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0048384
retinoic acid receptor signaling pathway
The module is grounded in the GO biological process term for retinoic acid receptor signaling pathway.
PANTHER:PTN000192666
PAINT node PTN000192666 for ALDH1A2
Local PAINT IBD node in PTHR11699 with propagated terms F:GO:0004029; PAINT date 20260528.
PANTHER:PTN000638895
PAINT node PTN000638895 for RXRA
Local PAINT IBD node in PTHR24083 with propagated terms C:GO:0005634, F:GO:0000978, F:GO:0004879, P:GO:0006357, P:GO:0030154; PAINT date 20260529.
PANTHER:PTN000639110
PAINT node PTN000639110 for RXRA
Local PAINT IBD node in PTHR24083 with propagated terms F:GO:0044323; PAINT date 20190426.
PANTHER:PTN001182089
PAINT node PTN001182089 for RARA
Local PAINT IBD node in PTHR24083 with propagated terms C:GO:0005634, F:GO:0000978, F:GO:0004879, P:GO:0045944; PAINT date 20260529.
PANTHER:PTN002278936
PAINT node PTN002278936 for CRABP2
Local PAINT IBD node in PTHR11955 with propagated terms C:GO:0005634, C:GO:0005829; PAINT date 20251218.
PANTHER:PTN002786703
PAINT node PTN002786703 for RXRA
Local PAINT IBD node in PTHR24083 with propagated terms C:GO:0090575, P:GO:0045944, P:GO:0048384; PAINT date 20250903.
PANTHER:PTN009080302
PAINT node PTN009080302 for RARA
Local PAINT IBD node in PTHR24083 with propagated terms P:GO:0030522; PAINT date 20250903.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
6Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • retinoic_acid_receptor_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/5 grounded genes reviewed)

0 complete review(s) · 1 with deep research · 4 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
NCOR1 O75376 ✗ — —
ALDH1A2 O94788 ✗ — —
RXRA P19793 ✗ — —
CRABP2 P29373 ✗ — —
RARA P10276 ✓ 156/159 ✓

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
Retinoic acid receptor signaling pathwaySignaling Pathwayretinoic_acid_receptor_signaling
retinoic acid receptor signaling pathwayGO:0048384
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes rar-rxr receptor activation.
RAR-RXR receptor activation leads to retinoid transcriptional output.
Part 1: retinoic acid production and transport
Retinoic acid production and transportRegulatory Stepretinoic_acid_production_and_transport

ALDH1A2 produces retinoic acid and CRABP2 helps deliver ligand to nuclear receptors.

Annotons

Retinaldehyde dehydrogenase
aldh1a2_retinaldehyde_dehydrogenase
Participant: Family: Retinaldehyde dehydrogenase family/ortholog group
Family:
Retinaldehyde dehydrogenase family/ortholog groupPANTHER:PTHR11699
Representative Members: ALDH1A2UniProtKB:O94788

Curated exemplar for the retinaldehyde dehydrogenase role in retinoic acid receptor signaling pathway.

Cellular retinoic acid-binding protein
crabp2_cellular_retinoic_acid_binding_protein
Participant: Family: Cellular retinoic acid-binding protein family/ortholog group
Family:
Cellular retinoic acid-binding protein family/ortholog groupPANTHER:PTHR11955
Representative Members: CRABP2UniProtKB:P29373

Curated exemplar for the cellular retinoic acid-binding protein role in retinoic acid receptor signaling pathway.

Part 2: rar-rxr receptor activation
RAR-RXR receptor activationRegulatory Steprar_rxr_receptor_activation

RARA and RXRA form ligand-responsive nuclear receptor complexes.

Annotons

Retinoic acid receptor alpha
rara_retinoic_acid_receptor_alpha
Participant: Family: Retinoic acid receptor alpha family/ortholog group
Family:
Retinoic acid receptor alpha family/ortholog groupPANTHER:PTHR24083
Representative Members: RARAUniProtKB:P10276

Curated exemplar for the retinoic acid receptor alpha role in retinoic acid receptor signaling pathway.

Retinoid X receptor alpha
rxra_retinoid_x_receptor_alpha
Participant: Family: Retinoid X receptor alpha family/ortholog group
Family:
Retinoid X receptor alpha family/ortholog groupPANTHER:PTHR24083
Representative Members: RXRAUniProtKB:P19793

Curated exemplar for the retinoid x receptor alpha role in retinoic acid receptor signaling pathway.

Part 3: retinoid transcriptional output
Retinoid transcriptional outputRegulatory Stepretinoid_transcriptional_output

RAR/RXR complexes exchange co-repressors and co-activators to regulate target-gene transcription.

Annotons

Nuclear receptor corepressor
ncor1_nuclear_receptor_corepressor
Participant: Gene Product: NCOR1
Gene Product:
NCOR1UniProtKB:O75376

Curated exemplar for the nuclear receptor corepressor role in retinoic acid receptor signaling pathway.

RAR transcriptional receptor
rara_rar_transcriptional_receptor
Participant: Family: RAR transcriptional receptor family/ortholog group
Family:
RAR transcriptional receptor family/ortholog groupPANTHER:PTHR24083
Representative Members: RARAUniProtKB:P10276

Curated exemplar for the rar transcriptional receptor role in retinoic acid receptor signaling pathway.