RIG-I signaling pathway module

RIG-I detects viral RNA and signals through MAVS to activate TBK1/IKK-family kinases and IRF transcription factors that induce type I interferon responses.

MODULE:rig_i_signalingDRAFTSignaling Pathwaymodules/rig_i_signaling.yaml
RIG-I signaling pathwayGO:0039529
file:modules/rig_i_signaling-deep-research-falcon.md
RIG-I signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0039529
RIG-I signaling pathway
The module is grounded in the GO biological process term for RIG-I signaling pathway.
PANTHER:PTN000540338
PAINT node PTN000540338 for TBK1
Local PAINT IBD node in PTHR22969 with propagated terms P:GO:0002218, P:GO:0032481; PAINT date 20240321.
PANTHER:PTN000805648
PAINT node PTN000805648 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms P:GO:0043122; PAINT date 20260528.
PANTHER:PTN001491808
PAINT node PTN001491808 for TBK1
Local PAINT IBD node in PTHR22969 with propagated terms C:GO:0005737, F:GO:0004674; PAINT date 20260601.
PANTHER:PTN008301857
PAINT node PTN008301857 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms P:GO:0007166; PAINT date 20250411.
PANTHER:PTN008494376
PAINT node PTN008494376 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms F:GO:0061630, P:GO:0045087; PAINT date 20230602.
PANTHER:PTN008938480
PAINT node PTN008938480 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms C:GO:0005737; PAINT date 20260528.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
5Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • rig_i_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (2/5 grounded genes reviewed)

1 complete review(s) · 2 with deep research · 3 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
RIGI O95786 ✗ — —
IRF3 Q14653 ✗ — —
MAVS Q7Z434 ✗ — —
TBK1 Q9UHD2 ✓ ✓ ✓
TRAF6 Q9Y4K3 ✓ 402/404 ✓

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
RIG-I signaling pathwaySignaling Pathwayrig_i_signaling
RIG-I signaling pathwayGO:0039529
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes mavs signalosome assembly.
MAVS signalosome assembly leads to tbk1 irf activation.
Part 1: viral rna sensing
RIG-I viral RNA sensingRegulatory Steprig_i_viral_rna_sensing

RIG-I recognizes viral RNA ligands in the cytosol.

Annotons

RIG-I RNA sensor
rigi_rig_i_rna_sensor
Participant: Gene Product: RIGI
Gene Product:
RIGIUniProtKB:O95786

Curated exemplar for the rig-i rna sensor role in RIG-I signaling pathway.

Part 2: mavs signalosome assembly
MAVS signalosome assemblyRegulatory Stepmavs_signalosome_assembly

Activated RIG-I couples to MAVS on mitochondrial membranes.

Annotons

MAVS adaptor
mavs_mavs_adaptor
Participant: Gene Product: MAVS
Gene Product:
MAVSUniProtKB:Q7Z434

Curated exemplar for the mavs adaptor role in RIG-I signaling pathway.

TRAF6 ubiquitin adaptor
traf6_traf6_ubiquitin_adaptor
Participant: Family: TRAF6 ubiquitin adaptor family/ortholog group
Family:
TRAF6 ubiquitin adaptor family/ortholog groupPANTHER:PTHR10131
Representative Members: TRAF6UniProtKB:Q9Y4K3

Curated exemplar for the traf6 ubiquitin adaptor role in RIG-I signaling pathway.

Part 3: tbk1 irf activation
TBK1-IRF activationRegulatory Steptbk1_irf_activation

TBK1 activates IRF3-centered antiviral transcriptional output.

Annotons

TBK1 kinase
tbk1_tbk1_kinase
Participant: Family: TBK1 kinase family/ortholog group
Family:
TBK1 kinase family/ortholog groupPANTHER:PTHR22969
Representative Members: TBK1UniProtKB:Q9UHD2

Curated exemplar for the tbk1 kinase role in RIG-I signaling pathway.

IRF3 transcription factor
irf3_irf3_transcription_factor
Participant: Gene Product: IRF3
Gene Product:
IRF3UniProtKB:Q14653

Curated exemplar for the irf3 transcription factor role in RIG-I signaling pathway.