The minimal, reusable membrane-fusion motif: cognate vesicle (v-/R-) and target (t-/Q-) SNAREs zipper into a four-helix trans-SNARE complex that pulls the two bilayers together; the resulting force drives membrane fusion and cargo delivery; and the ATPase NSF, with its SNAP cofactors, then disassembles the cis-SNARE complex to recycle the SNAREs for another round. This cycle underlies essentially all intracellular vesicular fusion (ER-Golgi, endosomal, synaptic-vesicle, etc.). The motif is gene-free and taxon-neutral, fixing only the SNARE-pairing and fusion roles and the pair -> fuse -> recycle topology. Grounded in GO:0006906 (vesicle fusion).
Reusable conformance target. A node declares `conforms_to: [{template: snare_fusion_cycle}]` when cognate SNAREs pair, drive fusion, and are recycled by NSF/SNAP. The specific SNARE set (syntaxin/SNAP-25/ VAMP, etc.) and compartment are realization-specific.
All recommended fields populated.
✗ none found
No MODULE:snare_fusion_cycle deep-research report alongside the module YAML.
3 leaf node(s) with no concrete protein grounding:
✓ every declared conforms_to bundle matches its template motif.
No concrete UniProt-grounded genes in this module.
Cognate vesicle and target SNAREs zipper into a four-helix trans-SNARE complex.
Forms the fusogenic trans-SNARE complex.
Trans-SNARE zippering pulls the bilayers together, driving fusion and cargo delivery.
Merges the membranes and delivers cargo.
The ATPase NSF, with SNAP cofactors, disassembles the cis-SNARE complex to recycle the SNAREs.
Recycles SNAREs for another fusion round.