Generic SNARE-mediated membrane fusion cycle motif

The minimal, reusable membrane-fusion motif: cognate vesicle (v-/R-) and target (t-/Q-) SNAREs zipper into a four-helix trans-SNARE complex that pulls the two bilayers together; the resulting force drives membrane fusion and cargo delivery; and the ATPase NSF, with its SNAP cofactors, then disassembles the cis-SNARE complex to recycle the SNAREs for another round. This cycle underlies essentially all intracellular vesicular fusion (ER-Golgi, endosomal, synaptic-vesicle, etc.). The motif is gene-free and taxon-neutral, fixing only the SNARE-pairing and fusion roles and the pair -> fuse -> recycle topology. Grounded in GO:0006906 (vesicle fusion).

MODULE:snare_fusion_cycleDRAFTTransport Stepmodules/snare_fusion_cycle.yaml
vesicle fusionGO:0006906
GO:0006906
vesicle fusion
The motif culminates in vesicle fusion driven by trans-SNARE complex assembly.
GO:0005484
SNAP receptor activity
The pairing role is SNARE (SNAP receptor) activity forming the fusogenic complex.

Reusable conformance target. A node declares `conforms_to: [{template: snare_fusion_cycle}]` when cognate SNAREs pair, drive fusion, and are recycled by NSF/SNAP. The specific SNARE set (syntaxin/SNAP-25/ VAMP, etc.) and compartment are realization-specific.

4Nodes
3Parts
0Variant Sets
0Variants
3Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:snare_fusion_cycle deep-research report alongside the module YAML.

Leaf nodes lacking representative members

3 leaf node(s) with no concrete protein grounding:

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
snare_activity ANY_WITH_FUNCTION
Gene 		SNAP receptor activity
GO:0005484 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.

Gene-review completeness (0/0 grounded genes reviewed)

No concrete UniProt-grounded genes in this module.

Details

SNARE pairing -> fusion -> NSF disassemblyTransport Stepsnare_fusion_cycle
vesicle fusionGO:0006906

Connections

Trans-SNARE complex assembly drives fusion.
snare_disassembly -> snare_pairing Provides Input For
NSF/SNAP recycling regenerates free SNAREs for the next round.
Part 1: trans-SNARE pairing
Cognate v-/t-SNARE pairingReactionsnare_pairing

Cognate vesicle and target SNAREs zipper into a four-helix trans-SNARE complex.

Annotons

SNAP receptor activity
snare_activity
Participant: Any With Function: SNAP receptor activity
Required Function:
SNAP receptor activityGO:0005484

Function

SNAP receptor activityGO:0005484

Forms the fusogenic trans-SNARE complex.

Part 2: membrane fusion
SNARE-driven membrane fusionTransport Stepmembrane_fusion

Trans-SNARE zippering pulls the bilayers together, driving fusion and cargo delivery.

Annotons

vesicle fusion
fusion_node
Participant: Any Participant

Processes

vesicle fusionGO:0006906

Merges the membranes and delivers cargo.

Part 3: NSF/SNAP disassembly and recycling
NSF/SNAP cis-SNARE disassemblyReactionsnare_disassembly

The ATPase NSF, with SNAP cofactors, disassembles the cis-SNARE complex to recycle the SNAREs.

Annotons

SNARE recycling
disassembly_node
Participant: Any Participant

Recycles SNAREs for another fusion round.