T cell receptor signaling pathway module

A compact T cell receptor (TCR) signaling module. Antigen-bound TCR/CD3 complexes are phosphorylated by Src-family kinases such as LCK, recruit and activate ZAP70, phosphorylate LAT/SLP76 adaptor scaffolds, and split into PLC gamma/calcium/NFAT, Ras-MAPK/AP-1, and PKC/NF-kappaB outputs. The module is grounded in GO:0050852 and uses PAINT PTN anchors for the LCK/ZAP70 non-receptor tyrosine kinase tier where the local cache supports them.

MODULE:t_cell_receptor_signalingDRAFTSignaling Pathwaymodules/t_cell_receptor_signaling.yaml
T cell receptor signaling pathwayGO:0050852
GO:0050852
T cell receptor signaling pathway
The module is grounded in the GO biological process term for T cell receptor signaling.
4Nodes
3Parts
0Variant Sets
0Variants
6Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:t_cell_receptor_signaling deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (0/7 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 7 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
LAT O43561 ✗ — —
NFATC1 O95644 ✗ — —
CD3D P04234 ✗ — —
LCK P06239 ✗ — —
CD3E P07766 ✗ — —
PLCG1 P19174 ✗ — —
ZAP70 P43403 ✗ — —

Details

Context
jawed vertebrates
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
T cell receptor signaling pathwaySignaling Pathwayt_cell_receptor_signaling
T cell receptor signaling pathwayGO:0050852
Context
jawed vertebrates
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

TCR/CD3 triggering licenses LCK phosphorylation of ITAMs and ZAP70 recruitment.
Activated ZAP70 phosphorylates LAT and organizes effector branches.
Part 1: TCR/CD3 triggering
Antigen-bound TCR/CD3 complex triggeringRegulatory Steptcr_cd3_triggering

Peptide-MHC binding to TCR reorganizes the TCR/CD3 complex and licenses phosphorylation of CD3 ITAMs.

Annotons

CD3 signaling subunits
cd3_complex
Participant: Protein Complex: TCR/CD3 signaling complex
Protein Complex:
TCR/CD3 signaling complex
Active units:
CD3D
Participant: Gene Product: CD3D
Gene Product:
CD3DUniProtKB:P04234
Role: ITAM-containing signaling subunit
CD3E
Participant: Gene Product: CD3E
Gene Product:
CD3EUniProtKB:P07766
Role: ITAM-containing signaling subunit

Processes

T cell receptor signaling pathwayGO:0050852

Antigen-receptor complex whose ITAMs initiate intracellular signaling.

Part 2: Src/Syk-family tyrosine kinase relay
LCK and ZAP70 tyrosine kinase activationReactionlck_zap70_relay

LCK phosphorylates CD3 ITAMs and supports recruitment/activation of ZAP70.

Annotons

LCK Src-family kinase
lck_kinase
Participant: Family: Src-family non-receptor tyrosine kinases
Family:
Src-family non-receptor tyrosine kinasesPANTHER:PTHR24418
Representative Members: LCKUniProtKB:P06239

Function

non-membrane spanning protein tyrosine kinase activityGO:0004715

Receptor-proximal Src-family kinase for CD3 ITAM phosphorylation.

ZAP70 kinase
zap70_kinase
Participant: Family: ZAP70/Syk-family tyrosine kinases
Family:
ZAP70/Syk-family tyrosine kinasesPANTHER:PTHR24418
Representative Members: ZAP70UniProtKB:P43403

Function

protein tyrosine kinase activityGO:0004713

Syk-family kinase that phosphorylates LAT and other adaptor proteins.

Part 3: LAT signalosome and transcriptional outputs
LAT signalosome branches to NFAT/AP-1/NF-kappaBRegulatory Steplat_signalosome_output

ZAP70-phosphorylated LAT organizes PLCG1 and other effectors that generate calcium/NFAT, Ras-MAPK/AP-1, and PKC/NF-kappaB output.

Annotons

LAT adaptor
lat_adaptor
Participant: Gene Product: LAT
Gene Product:
LATUniProtKB:O43561

Membrane adaptor scaffold for downstream TCR effector complexes.

PLC gamma effector
plc_gamma_effector
Participant: Gene Product: PLCG1
Gene Product:
PLCG1UniProtKB:P19174

Function

phospholipase C activityGO:0004629

Generates IP3/DAG for calcium, PKC, and NFAT/NF-kappaB branches.

NFAT transcriptional output
nfat_output
Participant: Gene Product: NFATC1
Gene Product:
NFATC1UniProtKB:O95644

Locations

nucleusGO:0005634

Calcium/calcineurin-responsive transcription factor downstream of TCR signaling.