A compact TGF-beta/SMAD signaling module. A dimeric TGF-beta family ligand binds type II and type I serine/threonine kinase receptors, the type II receptor activates the type I receptor, the type I receptor phosphorylates receptor-regulated SMADs, and SMAD complexes accumulate in the nucleus to regulate transcription. The module is grounded in GO:0007179. TGFB1 is anchored to PAINT TGF-beta-family nodes; receptors and SMADs are included as curated UniProt exemplars without PTN ancestry where local seed rows were not available.
All recommended fields populated.
✗ none found
No MODULE:tgfb_smad_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 complete review(s) · 1 with deep research · 5 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| TGFB1 P01137 | ✗ | — | — |
| TGFBR1 P36897 | ✗ | — | — |
| TGFBR2 P37173 | ✗ | — | — |
| SMAD4 Q13485 | ✗ | — | — |
| SMAD2 Q15796 | ✗ | — | — |
| SMAD3 P84022 | ✓ | ✓ | ✓ |
Mature dimeric TGF-beta ligand assembles a heterotetrameric receptor complex containing type II and type I receptor serine/threonine kinases.
Extracellular dimeric ligand that nucleates receptor complex formation.
Ligand-assembled kinase complex that activates SMAD2/3.
Activated TGFBR1 phosphorylates the C-terminal SSXS motif of SMAD2 and SMAD3, licensing complex formation with SMAD4.
Direct type I receptor substrates and signal carriers.
Phosphorylated SMAD2/3 bind SMAD4 and partner transcription factors, accumulate in the nucleus, and regulate TGF-beta target genes.
Co-SMAD that forms nuclear complexes with phosphorylated receptor-regulated SMADs.