A compact Toll-like receptor (TLR) signaling module. Ligand-bound TLRs recruit TIR-domain adaptors such as MYD88, activate IRAK kinases and TRAF6 ubiquitin ligase scaffolds, and route the signal through TAK1/IKK and MAPK branches to NF-kappaB, AP-1, and inflammatory gene expression. The module is grounded in GO:0002224 and includes PTN anchors for TRAF6-family ubiquitin-ligase and innate-immune roles where local PAINT seed rows support them.
All recommended fields populated.
✗ none found
No MODULE:toll_like_receptor_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 complete review(s) · 1 with deep research · 4 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| TLR4 O00206 | ✗ | — | — |
| MAP3K7 O43318 | ✗ | — | — |
| MYD88 Q99836 | ✗ | — | — |
| IRAK4 Q9NWZ3 | ✗ | — | — |
| TRAF6 Q9Y4K3 | ✓ | 402/404 | ✓ |
Ligand-bound TLRs dimerize or reorganize their TIR domains and recruit adaptor proteins, most prominently MYD88 for the canonical pro-inflammatory branch.
Pattern-recognition receptor exemplar for the pathway trunk.
TIR-domain adaptor that assembles the MYD88-dependent signaling complex.
MYD88 recruits IRAK kinases; activated IRAK proteins engage TRAF6, whose ubiquitin-ligase/scaffold activity promotes TAK1 and IKK/MAPK activation.
Receptor-proximal kinase in the MYD88-dependent TLR branch.
Ubiquitin-ligase/scaffold tier coupling IRAKs to TAK1/IKK/MAPK activation.
TAK1 activates IKK and MAPK branches that drive inflammatory transcriptional programs.
MAP3K tier that connects TRAF6 ubiquitin scaffolds to NF-kappaB and MAPK outputs.