A compact Toll-like receptor (TLR) signaling module. Ligand-bound TLRs recruit TIR-domain adaptors such as MYD88, activate IRAK kinases and TRAF6 ubiquitin ligase scaffolds, and route the signal through TAK1/IKK and MAPK branches to NF-kappaB, AP-1, and inflammatory gene expression. The module is grounded in GO:0002224 and includes PTN anchors for TRAF6-family ubiquitin-ligase and innate-immune roles where local PAINT seed rows support them.
Receptor-level detail is modelled in two submodules that show the intended term usage: modules/tlr2_heterodimer_lipopeptide_signaling.yaml (TLR1-TLR2 and TLR2-TLR6 as pattern recognition receptors for lipopeptides, GO:0038187) and modules/tlr4_md2_lps_signaling.yaml (TLR4-MD-2 as the lipopolysaccharide immune receptor, GO:0001875, with TIRAP-MYD88 and TRAM-TRIF branches).
All recommended fields populated.
✗ none found
No MODULE:toll_like_receptor_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
2 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| irak4_kinase | IRAK4 UniProtKB:Q9NWZ3 Gene |
protein serine/threonine kinase activity GO:0004674 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| traf6_ligase | TRAF6 UniProtKB:Q9Y4K3 Family Representative |
ubiquitin protein ligase activity GO:0061630 |
Annotation Supported
A retained annotation or curated replacement supports this function, but core_functions does not yet reflect it. |
| tak1_kinase | MAP3K7 UniProtKB:O43318 Gene |
protein serine/threonine kinase activity GO:0004674 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| traf6_ligase | TRAF adaptor/ubiquitin ligase family PANTHER:PTHR10131 Family |
ubiquitin protein ligase activity GO:0061630 |
Family Function Unreviewed
The family review has no applicable adjudication supporting or excluding GO:0061630. |
1 complete review(s) · 4 with deep research · 0 missing review · 1 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| IRAK4 Q9NWZ3 | ✓ | ✓ | ✓ |
| MAP3K7 O43318 | ✓ | 223/224 | ✗ |
| MYD88 Q99836 | ✓ | 228/229 | ✓ |
| TLR4 O00206 | ✓ | 274/275 | ✓ |
| TRAF6 Q9Y4K3 | ✓ | 402/404 | ✓ |
Ligand-bound TLRs dimerize or reorganize their TIR domains and recruit adaptor proteins, most prominently MYD88 for the canonical pro-inflammatory branch.
Pattern-recognition receptor exemplar for the pathway trunk.
TIR-domain adaptor that assembles the MYD88-dependent signaling complex.
MYD88 recruits IRAK kinases; activated IRAK proteins engage TRAF6, whose ubiquitin-ligase/scaffold activity promotes TAK1 and IKK/MAPK activation.
Receptor-proximal kinase in the MYD88-dependent TLR branch.
Ubiquitin-ligase/scaffold tier coupling IRAKs to TAK1/IKK/MAPK activation.
TAK1 activates IKK and MAPK branches that drive inflammatory transcriptional programs.
MAP3K tier that connects TRAF6 ubiquitin scaffolds to NF-kappaB and MAPK outputs.