Function
Toxin that inhibits DNA topoisomerase I, causing DNA/RNA synthesis defects and growth arrest when overproduced.
A protein-sequestration module for the Escherichia coli topAI-yjhQ toxin-antitoxin pair in which YjhQ acts as the antitoxin for TopAI/YjhX. YjhQ binding neutralizes TopAI toxicity and relieves TopAI-mediated inhibition of topoisomerase I. YjhQ's predicted GNAT-family acetyltransferase chemistry remains substrate-unknown and is outside this toxin-sequestering module.
TopAI/YjhX is modeled only at the TopAI-YjhQ boundary needed to describe the reviewed YjhQ antitoxin; a full TopAI/topoisomerase-I inhibition review should wait for dedicated TopAI curation.
All recommended fields populated.
✗ none found
No MODULE:topai_yjhq_toxin_antitoxin deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (2 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| topai_topa_inhibitor | E. coli TopAI/YjhX UniProtKB:Q2EEU2 Gene |
topoisomerase I inhibitor activity No function ID |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. The module function also lacks a GO identifier. |
| yjhq_topai_antitoxin | E. coli YjhQ UniProtKB:P39368 Gene |
toxin sequestering activity GO:0097351 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
✓ every negative regulator described as feedback has an upstream edge closing the loop.
1 complete review(s) · 1 with deep research · 1 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| E. coli TopAI/YjhX Q2EEU2 | ✗ | — | — |
| yjhQ P39368 | ✓ | ✓ | ✓ |
Toxin that inhibits DNA topoisomerase I, causing DNA/RNA synthesis defects and growth arrest when overproduced.
Antitoxin that physically binds TopAI and neutralizes its inhibition of topoisomerase I.