Type I interferon signaling pathway module

Type I interferons engage IFNAR receptor complexes and JAK1/TYK2 kinases to activate STAT1-STAT2-IRF9 transcriptional complexes that induce antiviral gene programs.

MODULE:type_i_interferon_signalingDRAFTSignaling Pathwaymodules/type_i_interferon_signaling.yaml
type I interferon-mediated signaling pathwayGO:0060337
file:modules/type_i_interferon_signaling-deep-research-falcon.md
Type I interferon signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0060337
type I interferon-mediated signaling pathway
The module is grounded in the GO biological process term for type I interferon-mediated signaling pathway.
PANTHER:PTN000210448
PAINT node PTN000210448 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0005634, C:GO:0005737, F:GO:0000978, F:GO:0000981, P:GO:0006357; PAINT date 20260528.
PANTHER:PTN000210451
PAINT node PTN000210451 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms P:GO:0019221; PAINT date 20260528.
PANTHER:PTN000210452
PAINT node PTN000210452 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0090575; PAINT date 20231129.
PANTHER:PTN000927860
PAINT node PTN000927860 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms P:GO:0006952, P:GO:0007259, P:GO:0042127; PAINT date 20260528.
PANTHER:PTN001562978
PAINT node PTN001562978 for JAK1
Local PAINT IBD node in PTHR45807 with propagated terms F:GO:0004715, P:GO:0007259, P:GO:0019221; PAINT date 20260530.
PANTHER:PTN002521566
PAINT node PTN002521566 for TYK2
Local PAINT IBD node in PTHR45807 with propagated terms F:GO:0005131; PAINT date 20260530.
PANTHER:PTN002623821
PAINT node PTN002623821 for STAT2
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0070721, P:GO:0060337; PAINT date 20231129.
PANTHER:PTN002623830
PAINT node PTN002623830 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0070721, P:GO:0060337; PAINT date 20231129.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
8Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • type_i_interferon_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (3/8 grounded genes reviewed)

2 complete review(s) · 2 with deep research · 5 missing review · 1 reviewed but lacking deep research

Gene Review Complete Deep research
JAK1 P23458 ✓ ✓ ✓
IFNA2 P01563 ✗ — —
IFNAR1 P17181 ✗ — —
TYK2 P29597 ✗ — —
IFNAR2 P48551 ✗ — —
IRF9 Q00978 ✗ — —
STAT1 P42224 ✓ 293/294 ✓
STAT2 P52630 ✓ ✓ ✗

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
Type I interferon signaling pathwaySignaling Pathwaytype_i_interferon_signaling
type I interferon-mediated signaling pathwayGO:0060337
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes jak kinase activation.
JAK1-TYK2 activation leads to isgf3 antiviral output.
Part 1: ifnar ligand-receptor engagement
IFN-alpha engages IFNARRegulatory Stepifn_alpha_engages_ifnar

IFNA2 binds IFNAR1/IFNAR2 receptor complexes.

Annotons

IFN-alpha ligand
ifna2_ifn_alpha_ligand
Participant: Gene Product: IFNA2
Gene Product:
IFNA2UniProtKB:P01563

Curated exemplar for the ifn-alpha ligand role in type I interferon-mediated signaling pathway.

IFNAR1 receptor chain
ifnar1_ifnar1_receptor_chain
Participant: Gene Product: IFNAR1
Gene Product:
IFNAR1UniProtKB:P17181

Curated exemplar for the ifnar1 receptor chain role in type I interferon-mediated signaling pathway.

IFNAR2 receptor chain
ifnar2_ifnar2_receptor_chain
Participant: Gene Product: IFNAR2
Gene Product:
IFNAR2UniProtKB:P48551

Curated exemplar for the ifnar2 receptor chain role in type I interferon-mediated signaling pathway.

Part 2: jak kinase activation
JAK1-TYK2 activationRegulatory Stepjak1_tyk2_activation

IFNAR receptor chains activate associated JAK1 and TYK2 kinases.

Annotons

JAK1 kinase
jak1_jak1_kinase
Participant: Family: JAK1 kinase family/ortholog group
Family:
JAK1 kinase family/ortholog groupPANTHER:PTHR45807
Representative Members: JAK1UniProtKB:P23458

Curated exemplar for the jak1 kinase role in type I interferon-mediated signaling pathway.

TYK2 kinase
tyk2_tyk2_kinase
Participant: Family: TYK2 kinase family/ortholog group
Family:
TYK2 kinase family/ortholog groupPANTHER:PTHR45807
Representative Members: TYK2UniProtKB:P29597

Curated exemplar for the tyk2 kinase role in type I interferon-mediated signaling pathway.

Part 3: isgf3 antiviral output
ISGF3 antiviral transcription outputRegulatory Stepisgf3_antiviral_transcription_output

STAT1, STAT2, and IRF9 form the ISGF3 transcriptional effector complex.

Annotons

STAT1 transcription factor
stat1_stat1_transcription_factor
Participant: Family: STAT1 transcription factor family/ortholog group
Family:
STAT1 transcription factor family/ortholog groupPANTHER:PTHR11801
Representative Members: STAT1UniProtKB:P42224

Curated exemplar for the stat1 transcription factor role in type I interferon-mediated signaling pathway.

STAT2 transcription factor
stat2_stat2_transcription_factor
Participant: Family: STAT2 transcription factor family/ortholog group
Family:
STAT2 transcription factor family/ortholog groupPANTHER:PTHR11801
Representative Members: STAT2UniProtKB:P52630

Curated exemplar for the stat2 transcription factor role in type I interferon-mediated signaling pathway.

IRF9 DNA-binding partner
irf9_irf9_dna_binding_partner
Participant: Gene Product: IRF9
Gene Product:
IRF9UniProtKB:Q00978

Curated exemplar for the irf9 dna-binding partner role in type I interferon-mediated signaling pathway.