Type II interferon signaling pathway module

Interferon-gamma engages IFNGR receptor complexes and JAK1/JAK2 kinases to activate STAT1-dependent transcriptional programs for macrophage activation and cell-mediated immunity.

MODULE:type_ii_interferon_signalingDRAFTSignaling Pathwaymodules/type_ii_interferon_signaling.yaml
type II interferon-mediated signaling pathwayGO:0060333
file:modules/type_ii_interferon_signaling-deep-research-falcon.md
Type II interferon signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0060333
type II interferon-mediated signaling pathway
The module is grounded in the GO biological process term for type II interferon-mediated signaling pathway.
PANTHER:PTN000210448
PAINT node PTN000210448 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0005634, C:GO:0005737, F:GO:0000978, F:GO:0000981, P:GO:0006357; PAINT date 20260528.
PANTHER:PTN000210451
PAINT node PTN000210451 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms P:GO:0019221; PAINT date 20260528.
PANTHER:PTN000210452
PAINT node PTN000210452 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0090575; PAINT date 20231129.
PANTHER:PTN000927860
PAINT node PTN000927860 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms P:GO:0006952, P:GO:0007259, P:GO:0042127; PAINT date 20260528.
PANTHER:PTN001562978
PAINT node PTN001562978 for JAK1
Local PAINT IBD node in PTHR45807 with propagated terms F:GO:0004715, P:GO:0007259, P:GO:0019221; PAINT date 20260530.
PANTHER:PTN002521566
PAINT node PTN002521566 for JAK2
Local PAINT IBD node in PTHR45807 with propagated terms P:GO:0060397; PAINT date 20241121.
PANTHER:PTN002623830
PAINT node PTN002623830 for STAT1
Local PAINT IBD node in PTHR11801 with propagated terms C:GO:0070721, P:GO:0060337; PAINT date 20231129.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
7Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • type_ii_interferon_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (2/6 grounded genes reviewed)

1 complete review(s) · 2 with deep research · 4 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
JAK1 P23458 ✓ ✓ ✓
JAK2 O60674 ✗ — —
IFNG P01579 ✗ — —
IFNGR1 P15260 ✗ — —
IFNGR2 P38484 ✗ — —
STAT1 P42224 ✓ 293/294 ✓

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
Type II interferon signaling pathwaySignaling Pathwaytype_ii_interferon_signaling
type II interferon-mediated signaling pathwayGO:0060333
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes ifngr jak activation.
JAK1-JAK2 activation leads to stat1 immune output.
Part 1: ifngr ligand-receptor engagement
IFN-gamma engages IFNGRRegulatory Stepifn_gamma_engages_ifngr

IFNG binds IFNGR1/IFNGR2 receptor complexes.

Annotons

IFN-gamma ligand
ifng_ifn_gamma_ligand
Participant: Gene Product: IFNG
Gene Product:
IFNGUniProtKB:P01579

Curated exemplar for the ifn-gamma ligand role in type II interferon-mediated signaling pathway.

IFNGR1 receptor chain
ifngr1_ifngr1_receptor_chain
Participant: Gene Product: IFNGR1
Gene Product:
IFNGR1UniProtKB:P15260

Curated exemplar for the ifngr1 receptor chain role in type II interferon-mediated signaling pathway.

IFNGR2 receptor chain
ifngr2_ifngr2_receptor_chain
Participant: Gene Product: IFNGR2
Gene Product:
IFNGR2UniProtKB:P38484

Curated exemplar for the ifngr2 receptor chain role in type II interferon-mediated signaling pathway.

Part 2: ifngr jak activation
JAK1-JAK2 activationRegulatory Stepjak1_jak2_activation

IFNGR-associated JAK1 and JAK2 phosphorylate receptor and STAT substrates.

Annotons

JAK1 kinase
jak1_jak1_kinase
Participant: Family: JAK1 kinase family/ortholog group
Family:
JAK1 kinase family/ortholog groupPANTHER:PTHR45807
Representative Members: JAK1UniProtKB:P23458

Curated exemplar for the jak1 kinase role in type II interferon-mediated signaling pathway.

JAK2 kinase
jak2_jak2_kinase
Participant: Family: JAK2 kinase family/ortholog group
Family:
JAK2 kinase family/ortholog groupPANTHER:PTHR45807
Representative Members: JAK2UniProtKB:O60674

Curated exemplar for the jak2 kinase role in type II interferon-mediated signaling pathway.

Part 3: stat1 immune output
STAT1 immune transcription outputRegulatory Stepstat1_immune_transcription_output

STAT1 activation relays IFN-gamma input to immune-response transcriptional programs.

Annotons

STAT1 transcription factor
stat1_stat1_transcription_factor
Participant: Family: STAT1 transcription factor family/ortholog group
Family:
STAT1 transcription factor family/ortholog groupPANTHER:PTHR11801
Representative Members: STAT1UniProtKB:P42224

Curated exemplar for the stat1 transcription factor role in type II interferon-mediated signaling pathway.

JAK2 kinase context
jak2_jak2_kinase_context
Participant: Family: JAK2 kinase context family/ortholog group
Family:
JAK2 kinase context family/ortholog groupPANTHER:PTHR45807
Representative Members: JAK2UniProtKB:O60674

Curated exemplar for the jak2 kinase context role in type II interferon-mediated signaling pathway.