VEGFR signaling pathway module

VEGF ligands activate endothelial VEGF receptor tyrosine kinases, coupling receptor phosphorylation to PLC-gamma, PI3K, and migration programs that drive vascular growth and permeability.

MODULE:vegfr_signalingDRAFTSignaling Pathwaymodules/vegfr_signaling.yaml
vascular endothelial growth factor receptor signaling pathwayGO:0048010
file:modules/vegfr_signaling-deep-research-falcon.md
VEGFR signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0048010
vascular endothelial growth factor receptor signaling pathway
The module is grounded in the GO biological process term for vascular endothelial growth factor receptor signaling pathway.
PANTHER:PTN000005673
PAINT node PTN000005673 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005737, C:GO:0016020, F:GO:0052742, P:GO:0046854; PAINT date 20260528.
PANTHER:PTN000005674
PAINT node PTN000005674 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005886, F:GO:0016303, F:GO:0035005, P:GO:0043491; PAINT date 20240205.
PANTHER:PTN000799655
PAINT node PTN000799655 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005942; PAINT date 20240516.
PANTHER:PTN000799659
PAINT node PTN000799659 for PIK3CG
Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005943, C:GO:0005944, F:GO:0046934; PAINT date 20240918.
PANTHER:PTN001230349
PAINT node PTN001230349 for KDR
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0005886, F:GO:0004714, P:GO:0007169; PAINT date 20260529.
PANTHER:PTN002814441
PAINT node PTN002814441 for KDR
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0005021, P:GO:0001525, P:GO:0030335, P:GO:0043408, P:GO:0045766; PAINT date 20250904.
PANTHER:PTN004704336
PAINT node PTN004704336 for KDR
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0019838; PAINT date 20240919.
PANTHER:PTN008302071
PAINT node PTN008302071 for PIK3R1
Local PAINT IBD node in PTHR10155 with propagated terms C:GO:0005943; PAINT date 20240516.
PANTHER:PTN008404985
PAINT node PTN008404985 for KDR
Local PAINT IBD node in PTHR24416 with propagated terms P:GO:0008284; PAINT date 20250904.
PANTHER:PTN008404994
PAINT node PTN008404994 for FLT1
Local PAINT IBD node in PTHR24416 with propagated terms F:GO:0005021, P:GO:0030335, P:GO:0043410, P:GO:0048010; PAINT date 20240425.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
7Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • vegfr_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/6 grounded genes reviewed)

0 complete review(s) · 1 with deep research · 5 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
FLT1 P17948 ✗ — —
PLCG1 P19174 ✗ — —
PIK3R1 P27986 ✗ — —
KDR P35968 ✗ — —
PIK3CG P48736 ✗ — —
VEGFA P15692 ✓ 246/269 ✓

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
VEGFR signaling pathwaySignaling Pathwayvegfr_signaling
vascular endothelial growth factor receptor signaling pathwayGO:0048010
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes phospholipase and lipid kinase recruitment.
PLC/PI3K recruitment leads to angiogenic output.
Part 1: vegf ligand-receptor engagement
VEGF ligand engages VEGFRRegulatory Stepvegf_ligand_engages_vegfr

VEGFA binds VEGFR family receptors such as KDR/VEGFR2 and FLT1/VEGFR1.

Annotons

VEGFA ligand
vegfa_vegfa_ligand
Participant: Gene Product: VEGFA
Gene Product:
VEGFAUniProtKB:P15692

Curated exemplar for the vegfa ligand role in vascular endothelial growth factor receptor signaling pathway.

KDR/VEGFR2 receptor
kdr_kdr_vegfr2_receptor
Participant: Family: KDR/VEGFR2 receptor family/ortholog group
Family:
KDR/VEGFR2 receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: KDRUniProtKB:P35968

Curated exemplar for the kdr/vegfr2 receptor role in vascular endothelial growth factor receptor signaling pathway.

FLT1/VEGFR1 receptor
flt1_flt1_vegfr1_receptor
Participant: Family: FLT1/VEGFR1 receptor family/ortholog group
Family:
FLT1/VEGFR1 receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: FLT1UniProtKB:P17948

Curated exemplar for the flt1/vegfr1 receptor role in vascular endothelial growth factor receptor signaling pathway.

Part 2: phospholipase and lipid kinase recruitment
PLC/PI3K recruitmentRegulatory Stepplc_pi3k_recruitment

Activated VEGFR recruits PLCG and PI3K signaling effectors.

Annotons

PLCG1 effector
plcg1_plcg1_effector
Participant: Gene Product: PLCG1
Gene Product:
PLCG1UniProtKB:P19174

Curated exemplar for the plcg1 effector role in vascular endothelial growth factor receptor signaling pathway.

PI3K p85 adaptor
pik3r1_pi3k_p85_adaptor
Participant: Family: PI3K p85 adaptor family/ortholog group
Family:
PI3K p85 adaptor family/ortholog groupPANTHER:PTHR10155
Representative Members: PIK3R1UniProtKB:P27986

Curated exemplar for the pi3k p85 adaptor role in vascular endothelial growth factor receptor signaling pathway.

Part 3: angiogenic output
Endothelial angiogenic outputRegulatory Stependothelial_angiogenic_output

VEGFR signaling promotes endothelial migration, proliferation, and survival.

Annotons

VEGFR2 kinase output
kdr_vegfr2_kinase_output
Participant: Family: VEGFR2 kinase output family/ortholog group
Family:
VEGFR2 kinase output family/ortholog groupPANTHER:PTHR24416
Representative Members: KDRUniProtKB:P35968

Curated exemplar for the vegfr2 kinase output role in vascular endothelial growth factor receptor signaling pathway.

PI3K catalytic branch
pik3cg_pi3k_catalytic_branch
Participant: Family: PI3K catalytic branch family/ortholog group
Family:
PI3K catalytic branch family/ortholog groupPANTHER:PTHR10048
Representative Members: PIK3CGUniProtKB:P48736

Curated exemplar for the pi3k catalytic branch role in vascular endothelial growth factor receptor signaling pathway.