Contractile vacuole tethering obsoletion

BP GO:0140025 → MF GO:7770067 contractile vacuole-plasma membrane tether activity

AI Gene Review · projects/CONTRACTILE_VACUOLE_TETHERING_OBSOLETION · 2026

Bottom line

  • GO obsoleted the process GO:0140025 and replaced it with a new molecular function, GO:7770067 (is_a GO:0140177 membrane-membrane adaptor activity).
  • Only 2 annotations move, both Dictyostelium IMP: rab8A and p2xA.
  • Scoped, not yet started: neither gene is reviewed here; p2xA needs a careful look.

Why a process became a function

  • Tethering is a binding activity that bridges two membranes, so GO models it as an MF.
  • Same pattern as the sibling tether obsoletions: ER-PM, mito-ER, vesicle tethering (GO:7770062).
  • Upstream: go-ontology #31870; new term PR #31942; obsoletion PR #31950.
  • No InterPro2GO, UniProt keyword or UniRule mappings to redirect.

What the tether does

Old term → new term, and the two rows

Review plan

  • rab8A (P20790): anchor review. PMID:22323285 is the paper cited in the new term's definition; the new MF is the likely core function, with the exocyst link and contractile vacuole discharge (GO:0070177) as context.
  • p2xA (Q86JM7): P2X receptors are cation channels. Check that PMID:24335649 shows tethering and not a channel-dependent regulatory role before accepting the MF.
  • genes/DICDI/ has 56 reviews; neither gene is among them.

Status and next steps

  1. Confirm dictyBase has migrated the two IMP rows to GO:7770067 (upstream said they "may be automatically transferred").
  2. just fetch-gene DICDI rab8A, then p2xA.
  3. These two reviews close the whole GO:0140025 migration.

Upstream: go-annotation#6387 · go-ontology#31870, #31942, #31950
Siblings: ER_PM_TETHERING_OBSOLETION · MITO_ER_TETHERING_OBSOLETION · VESICLE_TETHERING_OBSOLETION
Page: projects/CONTRACTILE_VACUOLE_TETHERING_OBSOLETION.md