{
  "query": "family:\"cytochrome P450 family\" AND organism_id:9606 AND reviewed:true",
  "rhea2go_go_release": "releases/2026-07-26",
  "retrieved_at": "2026-10-14T17:49:48Z",
  "ec2go_go_release": "releases/2026-07-26",
  "entries": 60,
  "entries_with_reactions": 57,
  "reaction_annotations": 556,
  "experimental_reaction_annotations": 528,
  "distinct_reactions": 297,
  "mapped_reactions": 96,
  "unmapped_reactions": 201,
  "unmapped_reactions_no_ec": 191,
  "distinct_mf_terms": 107,
  "catalytic_mf_terms": 89,
  "hub_threshold": 20,
  "catalytic_term_descendant_counts": [
    [
      "GO:0016491",
      "oxidoreductase activity",
      81
    ],
    [
      "GO:0004497",
      "monooxygenase activity",
      70
    ],
    [
      "GO:0016705",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
      61
    ],
    [
      "GO:0016712",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
      29
    ],
    [
      "GO:0008395",
      "steroid hydroxylase activity",
      24
    ],
    [
      "GO:0016713",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen",
      6
    ],
    [
      "GO:0008391",
      "arachidonate monooxygenase activity",
      5
    ],
    [
      "GO:0008387",
      "steroid 7-alpha-hydroxylase activity",
      4
    ],
    [
      "GO:0008392",
      "arachidonate epoxygenase activity",
      4
    ],
    [
      "GO:0016709",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen",
      4
    ],
    [
      "GO:0016853",
      "isomerase activity",
      3
    ],
    [
      "GO:0120250",
      "fatty acid omega-hydroxylase activity",
      3
    ],
    [
      "GO:0004509",
      "steroid 21-monooxygenase activity",
      2
    ],
    [
      "GO:0070576",
      "vitamin D 24-hydroxylase activity",
      2
    ],
    [
      "GO:0120502",
      "fatty acid omega-1 hydroxylase activity",
      2
    ],
    [
      "GO:0008401",
      "retinoic acid 4-hydroxylase activity",
      1
    ],
    [
      "GO:0016716",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen",
      1
    ],
    [
      "GO:0016836",
      "hydro-lyase activity",
      1
    ],
    [
      "GO:0032451",
      "demethylase activity",
      1
    ]
  ],
  "hub_terms": [
    [
      "GO:0004497",
      "monooxygenase activity"
    ],
    [
      "GO:0008395",
      "steroid hydroxylase activity"
    ],
    [
      "GO:0016491",
      "oxidoreductase activity"
    ],
    [
      "GO:0016705",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"
    ],
    [
      "GO:0016712",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"
    ]
  ],
  "substrate_naming_mf_terms": 84,
  "maximally_specific_mf_terms": 70,
  "binding_mf_terms": 16,
  "tiers": {
    "substrate-resolved": 52,
    "partially-resolved": 4,
    "unresolved": 4
  },
  "reviews_in_repo": 13,
  "reviewed_genes": [
    "CYP11A1",
    "CYP11B1",
    "CYP11B2",
    "CYP17A1",
    "CYP19A1",
    "CYP21A2",
    "CYP27A1",
    "CYP39A1",
    "CYP46A1",
    "CYP51A1",
    "CYP7A1",
    "CYP7B1",
    "CYP8B1"
  ],
  "unresolved_cyps": [
    [
      "CYP4F22",
      "Q6NT55",
      2,
      "Ichthyosis, congenital, autosomal recessive 5"
    ],
    [
      "CYP20A1",
      "Q6UW02",
      0,
      ""
    ],
    [
      "CYP4Z2P",
      "Q8N1L4",
      0,
      ""
    ],
    [
      "CYP2G1P",
      "Q6ZSU1",
      0,
      ""
    ]
  ],
  "resolved_mf_provenance": {
    "experimental": 48,
    "IBA": 4,
    "other-inferred": 4
  },
  "propagation_gap_pairs": 0,
  "top_unmapped_chemistry": [
    [
      "hydroxylation",
      "steroid / sterol",
      34
    ],
    [
      "other/unclassified",
      "steroid / sterol",
      31
    ],
    [
      "hydroxylation",
      "eicosanoid / PUFA",
      28
    ],
    [
      "hydroxylation",
      "other fatty acid",
      18
    ],
    [
      "epoxidation",
      "eicosanoid / PUFA",
      15
    ],
    [
      "other/unclassified",
      "other/unclassified",
      14
    ],
    [
      "hydroxylation",
      "other/unclassified",
      10
    ],
    [
      "oxo-formation (alcohol to aldehyde/ketone)",
      "steroid / sterol",
      8
    ],
    [
      "aromatization (formate-releasing)",
      "steroid / sterol",
      5
    ],
    [
      "other/unclassified",
      "other fatty acid",
      5
    ]
  ]
}