Geranylgeranyl reductase activity obsoletion

GO:0045550 → GO:0102067 geranylgeranyl diphosphate reductase activity

AI Gene Review · projects/GERANYLGERANYL_REDUCTASE_OBSOLETION · reviewed 2026-10-04

Bottom line

  • GO obsoleted GO:0045550, which lacked an enzyme cross-reference, and replaced it with GO:0102067 (EC 1.3.1.83).
  • Of 4 experimental rows, Arabidopsis CHLP fits cleanly; tobacco CHLP has weaker NAS evidence; the two human AKR rows need a substrate check before moving.
  • Still queued: no AKR1C3, AKR1B10, or CHLP review exists here; #363 tracks the open curation.

Old term → replacement

The reaction the new term names

Why this is not a pure rename

  • The old label said "geranylgeranyl"; the new one says geranylgeranyl diphosphate.
  • GO:0102067 also covers reduction of geranylgeranyl-chlorophyll a, the other in vivo substrate.
  • An enzyme shown to reduce a different geranylgeranyl compound does not automatically fit.
  • The archaeal IPR023590 family reduces a glycerophospholipid, not free GGPP; its mapping deserves the same question.

Next steps

  1. Review AKR1C3 (human, P42330) first, reading PMID:21187079 for the substrate actually tested.
  2. Then AKR1B10 (same paper).
  3. Arabidopsis CHLP as the positive control for GO:0102067; treat the tobacco NAS row separately.
  4. Verify the CHLP-family mappings; raise the IPR023590 fit on go-annotation#6394.

Upstream: go-annotation#6394 open · go-ontology#31963 closed
Read more: projects/GERANYLGERANYL_REDUCTASE_OBSOLETION.md