Geranylgeranyl reductase activity obsoletion

GO:0045550 → GO:0102067 geranylgeranyl diphosphate reductase activity

AI Gene Review · projects/GERANYLGERANYL_REDUCTASE_OBSOLETION · 2026

Bottom line

  • GO obsoleted GO:0045550, which lacked an enzyme cross-reference, and merged it into GO:0102067 (EC 1.3.1.83).
  • Of 4 experimental rows, the two plant CHLP rows fit; the two human AKR rows (AKR1C3, AKR1B10) need a substrate check before moving.
  • Scoped, not yet started: none of the four genes has a review in this repo.

Old term → replacement

The reaction the new term names

Why this is not a pure rename

  • The old label said "geranylgeranyl"; the new one says geranylgeranyl diphosphate.
  • GO:0102067 also covers reduction of geranylgeranyl-chlorophyll a, the other in vivo substrate.
  • An enzyme shown to reduce a different geranylgeranyl compound does not automatically fit.
  • The archaeal IPR023590 family reduces a glycerophospholipid, not free GGPP; its mapping deserves the same question.

Next steps

  1. Review AKR1C3 (human, P42330) first, reading PMID:21187079 for the substrate actually tested.
  2. Then AKR1B10 (same paper).
  3. Arabidopsis CHLP as the positive control for GO:0102067; treat the tobacco NAS row separately.
  4. Raise the IPR023590 fit on go-annotation#6394.

Upstream: go-annotation#6394 · go-ontology#31963
Read more: projects/GERANYLGERANYL_REDUCTASE_OBSOLETION.md