summary: n_models: 2036 n_models_with_unresolved: 338 n_models_with_nonadjacent: 106 n_nonadjacent_direct_edges: 54 n_models_with_relocating: 9 n_models_with_explained: 40 location_status: AMBIGUOUS: 15 COARSE: 2203 MISSING: 1976 RESOLVED: 7417 UNRESOLVED: 974 edge_status: ADJACENT: 1207 BRIDGED: 63 EXPLAINED: 73 INDETERMINATE: 2956 NONADJACENT: 179 RELOCATING: 12 SAME: 4676 unresolved_terms: - term: GO:0000785 label: chromatin n_activities: 193 - term: GO:0035861 label: site of double-strand break n_activities: 115 - term: GO:0106139 label: symbiont cell surface n_activities: 59 - term: GO:0030430 label: host cell cytoplasm n_activities: 40 - term: GO:0090734 label: site of DNA damage n_activities: 36 - term: GO:0005721 label: pericentric heterochromatin n_activities: 34 - term: GO:0000792 label: heterochromatin n_activities: 32 - term: GO:0005813 label: centrosome n_activities: 22 - term: GO:0031934 label: mating-type region heterochromatin n_activities: 21 - term: GO:0044732 label: mitotic spindle pole body n_activities: 21 - term: GO:0005575 label: cellular_component n_activities: 20 - term: GO:1990819 label: mating projection actin fusion focus n_activities: 20 - term: GO:0000776 label: kinetochore n_activities: 17 - term: GO:0005657 label: replication fork n_activities: 15 - term: GO:0032153 label: cell division site n_activities: 15 - term: GO:0045202 label: synapse n_activities: 14 - term: GO:0140268 label: endoplasmic reticulum-plasma membrane contact site n_activities: 14 - term: GO:0140720 label: subtelomeric heterochromatin n_activities: 13 - term: GO:0160258 label: endoplasmic reticulum-trans-Golgi network membrane contact site n_activities: 13 - term: CL:0000235 label: macrophage n_activities: 10 - term: GO:0005912 label: adherens junction n_activities: 10 - term: GO:0042025 label: host cell nucleus n_activities: 10 - term: CL:0000121 label: Purkinje cell n_activities: 9 - term: GO:0005815 label: microtubule organizing center n_activities: 9 - term: GO:0044233 label: mitochondria-associated endoplasmic reticulum membrane contact site n_activities: 9 - term: GO:0005874 label: microtubule n_activities: 8 - term: GO:0043332 label: mating projection tip n_activities: 8 - term: GO:0005694 label: chromosome n_activities: 7 - term: GO:0044218 label: other organism cell membrane n_activities: 7 - term: GO:0005925 label: focal adhesion n_activities: 6 - term: GO:0012505 label: endomembrane system n_activities: 6 - term: GO:0000805 label: X chromosome n_activities: 5 - term: GO:0035974 label: meiotic spindle pole body n_activities: 5 - term: GO:0071958 label: new mitotic spindle pole body n_activities: 5 - term: GO:0000781 label: chromosome, telomeric region n_activities: 4 - term: GO:0020002 label: host cell plasma membrane n_activities: 4 - term: GO:0036064 label: ciliary basal body n_activities: 4 - term: GO:0039718 label: double membrane vesicle viral factory n_activities: 4 - term: GO:0071957 label: old mitotic spindle pole body n_activities: 4 - term: CL:0000057 label: fibroblast n_activities: 3 - term: CL:0000100 label: motor neuron n_activities: 3 - term: CL:0000771 label: eosinophil n_activities: 3 - term: GO:0000775 label: chromosome, centromeric region n_activities: 3 - term: GO:0005819 label: spindle n_activities: 3 - term: GO:0030027 label: lamellipodium n_activities: 3 - term: GO:0031594 label: neuromuscular junction n_activities: 3 - term: GO:0044309 label: neuron spine n_activities: 3 - term: GO:0051286 label: cell tip n_activities: 3 - term: GO:0055036 label: virion membrane n_activities: 3 - term: GO:0099092 label: postsynaptic density, intracellular component n_activities: 3 - term: GO:0140284 label: endoplasmic reticulum-endosome membrane contact site n_activities: 3 - term: CL:0000120 label: granule cell n_activities: 2 - term: CL:0000138 label: chondrocyte n_activities: 2 - term: CL:0000232 label: erythrocyte n_activities: 2 - term: CL:0000540 label: neuron n_activities: 2 - term: CL:0000764 label: erythroid lineage cell n_activities: 2 - term: GO:0000779 label: condensed chromosome, centromeric region n_activities: 2 - term: GO:0005911 label: cell-cell junction n_activities: 2 - term: GO:0005923 label: bicellular tight junction n_activities: 2 - term: GO:0005937 label: mating projection n_activities: 2 - term: GO:0015629 label: actin cytoskeleton n_activities: 2 - term: GO:0030496 label: midbody n_activities: 2 - term: GO:0034451 label: centriolar satellite n_activities: 2 - term: GO:0035770 label: ribonucleoprotein granule n_activities: 2 - term: GO:0043025 label: neuronal cell body n_activities: 2 - term: GO:0043655 label: host extracellular region n_activities: 2 - term: GO:0045095 label: keratin filament n_activities: 2 - term: GO:0072686 label: mitotic spindle n_activities: 2 - term: GO:0072687 label: meiotic spindle n_activities: 2 - term: GO:0097542 label: ciliary tip n_activities: 2 - term: GO:0140494 label: migrasome n_activities: 2 - term: UBERON:0002329 label: somite n_activities: 2 - term: WBbt:0005772 label: intestine n_activities: 2 - term: CL:0000066 label: epithelial cell n_activities: 1 - term: CL:0000117 label: CNS neuron (sensu Vertebrata) n_activities: 1 - term: CL:0000166 label: chromaffin cell n_activities: 1 - term: CL:0000169 label: type B pancreatic cell n_activities: 1 - term: CL:0000336 label: adrenal medulla chromaffin cell n_activities: 1 - term: CL:1000458 label: melanocyte of skin n_activities: 1 - term: EMAPA:16910 label: telencephalon n_activities: 1 - term: EMAPA:17787 label: cerebellum n_activities: 1 - term: EMAPA:19142 label: tibia n_activities: 1 - term: EMAPA:32760 label: bone marrow n_activities: 1 - term: EMAPA:32927 label: islets of Langerhans n_activities: 1 - term: EMAPA:35840 label: superior olivary nucleus n_activities: 1 - term: GO:0000935 label: division septum n_activities: 1 - term: GO:0000936 label: primary cell septum n_activities: 1 - term: GO:0001725 label: stress fiber n_activities: 1 - term: GO:0005856 label: cytoskeleton n_activities: 1 - term: GO:0005884 label: actin filament n_activities: 1 - term: GO:0007094 label: mitotic spindle assembly checkpoint signaling n_activities: 1 - term: GO:0014069 label: postsynaptic density n_activities: 1 - term: GO:0019013 label: viral nucleocapsid n_activities: 1 - term: GO:0030424 label: axon n_activities: 1 - term: GO:0043231 label: intracellular membrane-bounded organelle n_activities: 1 - term: GO:0043232 label: intracellular membraneless organelle n_activities: 1 - term: GO:0044164 label: host cell cytosol n_activities: 1 - term: GO:0044165 label: host cell endoplasmic reticulum n_activities: 1 - term: GO:0044167 label: host cell endoplasmic reticulum membrane n_activities: 1 - term: GO:0044178 label: host cell Golgi membrane n_activities: 1 - term: GO:0044228 label: host cell surface n_activities: 1 - term: GO:0044292 label: dendrite terminus n_activities: 1 - term: GO:0044295 label: axonal growth cone n_activities: 1 - term: GO:0044423 label: virion component n_activities: 1 - term: GO:0048786 label: presynaptic active zone n_activities: 1 - term: GO:0060076 label: excitatory synapse n_activities: 1 - term: GO:0061497 label: inner plaque of mitotic spindle pole body n_activities: 1 - term: GO:0070648 label: formin-nucleated actin cable n_activities: 1 - term: GO:0072324 label: ascus epiplasm n_activities: 1 - term: GO:0075341 label: host cell PML body n_activities: 1 - term: GO:0097730 label: non-motile cilium n_activities: 1 - term: GO:0098684 label: photoreceptor ribbon synapse n_activities: 1 - term: GO:0099182 label: presynaptic intermediate filament cytoskeleton n_activities: 1 - term: UBERON:0003926 label: photoreceptor outer segment layer n_activities: 1 - term: WBbt:0003679 label: neuron n_activities: 1 - term: XAO:0001001 label: cranial neural crest n_activities: 1 - term: ZFA:0000023 label: forerunner cell group n_activities: 1 - term: ZFA:0000155 label: somite n_activities: 1 - term: ZFA:0009065 label: endothelial cell n_activities: 1 models: - model: gomodel:568b0f9600000284 title: Antibacterial innate immune response in the intestine via MAPK cascade (C. elegans) n_activities: 10 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:568b0f9600000284/568b0f9600000287 upstream_label: atf-7 Cele downstream: gomodel:568b0f9600000284/580685bd00000135 downstream_label: sysm-1 Cele predicate: RO:0002630 predicate_label: directly negatively regulates direct: true upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:586fc17a00000528 title: PRCD-human-retinitis pigmentosa n_activities: 2 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:586fc17a00000528/586fc17a00000544 gene_product: UniProtKB:Q00LT1 gene_label: PRCD Hsap occurs_in: UBERON:0003926 occurs_in_label: photoreceptor outer segment layer status: UNRESOLVED compartments: [] edges: [] - model: gomodel:59cc772c00000000 title: IL1beta-mediated signaling pathway (Human) n_activities: 9 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:59cc772c00000000/626b20c100001883 upstream_label: CASP1 Hsap downstream: gomodel:59cc772c00000000/59cc772c00000002 downstream_label: IL1B Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - CYTOSOL downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:59dc728000000555 title: ' Wnt-FGF-Notch signaling inregulation of HSC specification via dlc, dld, fgfr4, wnt16 (D. rerio)' n_activities: 5 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:59dc728000000555/59dc728000000556 gene_product: ZFIN:ZDB-GENE-040426-2330 gene_label: wnt16 Drer occurs_in: UBERON:0002329 occurs_in_label: somite status: UNRESOLVED compartments: [] - activity_id: gomodel:59dc728000000555/59dc728000000582 gene_product: ZFIN:ZDB-GENE-040426-2330 gene_label: wnt16 Drer occurs_in: UBERON:0002329 occurs_in_label: somite status: UNRESOLVED compartments: [] edges: [] - model: gomodel:5ae3b0f600000435 title: Regulation of sprouting angiogenesis via dll4, egfl6, itgb1a (D. rerio) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5ae3b0f600000435/5fce9b7300000196 gene_product: ZFIN:ZDB-GENE-040718-157 gene_label: egfl6 Drer occurs_in: ZFA:0000155 occurs_in_label: somite status: UNRESOLVED compartments: [] - activity_id: gomodel:5ae3b0f600000435/5fce9b7300000179 gene_product: ZFIN:ZDB-GENE-060803-2 gene_label: itgb1a Drer occurs_in: ZFA:0009065 occurs_in_label: endothelial cell status: UNRESOLVED compartments: [] edges: [] - model: gomodel:5b528b1100000489 title: XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity n_activities: 5 n_causal_edges: 3 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5b528b1100000489/5b528b1100000541 gene_product: WB:WBGene00002147 gene_label: ire-1 Cele occurs_in: WBbt:0005772 occurs_in_label: intestine status: UNRESOLVED compartments: [] - activity_id: gomodel:5b528b1100000489/5b528b1100000525 gene_product: WB:WBGene00006752 gene_label: unc-13 Cele occurs_in: GO:0048786 occurs_in_label: presynaptic active zone status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:5b528b1100000489/5b528b1100000498 gene_product: WB:WBGene00006959 gene_label: xbp-1 Cele occurs_in: WBbt:0003679 occurs_in_label: neuron status: UNRESOLVED compartments: [] - activity_id: gomodel:5b528b1100000489/5b528b1100000518 gene_product: WB:WBGene00002147 gene_label: ire-1 Cele occurs_in: GO:0043025 occurs_in_label: neuronal cell body status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:5b528b1100000489/5b528b1100000547 gene_product: WB:WBGene00006959 gene_label: xbp-1 Cele occurs_in: WBbt:0005772 occurs_in_label: intestine status: UNRESOLVED compartments: [] edges: [] - model: gomodel:5ce58dde00001215 title: Mouse-Aatf-antiapoptosis n_activities: 5 n_causal_edges: 1 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5ce58dde00001215/5ce58dde00001232 gene_product: MGI:MGI:1328355 gene_label: Wfs1 Mmus occurs_in: CL:0000169 occurs_in_label: type B pancreatic cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:5ce58dde00001215/6870555700004734 gene_product: MGI:MGI:103038 gene_label: Stat3 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: &id001 id: GO:0000228 label: nuclear chromosome note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:5e72450500004237 title: SARS-COV2/cycle from polyprotein processing to viral genome replication (SRAS-COV-2) n_activities: 11 n_causal_edges: 10 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5e72450500004237/5f46c3b700000754 gene_product: UniProtKB:P0DTC9 gene_label: N protein Scov2 occurs_in: GO:0019013 occurs_in_label: viral nucleocapsid status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:5e72450500004237/60418ffa00002814 gene_product: UniProtKB:P0DTD1-PRO_0000449631 gene_label: nsp14 Scov2 occurs_in: GO:0039718 occurs_in_label: double membrane vesicle viral factory status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:5e72450500004237/5f46c3b700000325 gene_product: UniProtKB:P0DTD1-PRO_0000449629 gene_label: nsp12 Scov2 occurs_in: GO:0039718 occurs_in_label: double membrane vesicle viral factory status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:5e72450500004237/5f46c3b700000333 gene_product: UniProtKB:P0DTD1-PRO_0000449625 gene_label: nsp7 Scov2 occurs_in: GO:0039718 occurs_in_label: double membrane vesicle viral factory status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:5e72450500004237/5f46c3b700000329 gene_product: UniProtKB:P0DTD1-PRO_0000449630 gene_label: nsp13 Scov2 occurs_in: GO:0039718 occurs_in_label: double membrane vesicle viral factory status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:5ee8120100001898 title: Migrasome signaling involved in organ morphogenesis via cxcl12a, cxcr4b, tspan4a, tspan7 (D. rerio) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5ee8120100001898/5ee8120100002541 gene_product: ZFIN:ZDB-GENE-030318-1 gene_label: cxcl12a Drer occurs_in: GO:0140494 occurs_in_label: migrasome status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:5ee8120100001898/60747c4200000449 gene_product: ZFIN:ZDB-GENE-030318-1 gene_label: cxcl12a Drer occurs_in: GO:0140494 occurs_in_label: migrasome status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:5ee8120100001898/5fb9cc0600000049 gene_product: ZFIN:ZDB-GENE-010614-1 gene_label: cxcr4b Drer occurs_in: ZFA:0000023 occurs_in_label: forerunner cell group status: UNRESOLVED compartments: [] edges: [] - model: gomodel:5f46c3b700000011 title: ret signaling regulating axon outgrowth via ret, mapk8ip3, myo10l1 (D. rerio) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5f46c3b700000011/5f46c3b700000017 gene_product: ZFIN:ZDB-GENE-080425-1 gene_label: myo10l1 Drer occurs_in: GO:0044295 occurs_in_label: axonal growth cone status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:5f46c3b700002685 title: IL6:sIL6R Trans-signaling pathway (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:5f46c3b700002685/5f46c3b700002806 upstream_label: STAT3 Hsap downstream: gomodel:5f46c3b700002685/5f46c3b700002821 downstream_label: SOCS3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:5f46c3b700002685/5f46c3b700002801 upstream_label: JAK1 Hsap downstream: gomodel:5f46c3b700002685/5f46c3b700002806 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:5fadbcf000000317 title: Fzd3 function in Cranial neural crest cells n_activities: 16 n_causal_edges: 14 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5fadbcf000000317/5fadbcf000001187 gene_product: Xenbase:XB-GENE-483735 gene_label: fzd7.L Xlae occurs_in: XAO:0001001 occurs_in_label: cranial neural crest status: UNRESOLVED compartments: [] edges: [] - model: gomodel:5fadbcf000001646 title: SP_SIK2-actvity-on-P300 n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5fadbcf000001646/6197061700000050 gene_product: UniProtKB:Q9NP71 gene_label: MLXIPL Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:5fadbcf000001646/6197061700000048 gene_product: UniProtKB:Q09472 gene_label: EP300 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:5fadbcf000001646/6197061700000055 gene_product: UniProtKB:Q9NP71 gene_label: MLXIPL Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:5fadbcf000001962 title: T-helper 17 cell lineage commitment by IL6 cluster (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:5fadbcf000001962/5fadbcf000001990 upstream_label: JAK1 Hsap downstream: gomodel:5fadbcf000001962/5fadbcf000001997 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:5fce9b7300000030 title: 'Diacyl lipopeptide and bacteriocin activation of TLR6_TLR2 receptor (Human) ' n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:5fce9b7300000030/663d668500002749 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:600ced8500002343 title: BMP9 signaling pathway (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:600ced8500002343/6446bfcb00001798 gene_product: UniProtKB:Q15797 gene_label: SMAD1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6086f4f200000298 title: SARS-CoV-2/autophagy n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6086f4f200000298/60897d8500000034 upstream_label: VPS39 Hsap downstream: gomodel:6086f4f200000298/60897d8500000001 downstream_label: STX17 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE downstream_compartments: - VACUOLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:60ad85f700000058 title: Atf2 mouse n_activities: 59 n_causal_edges: 6 n_unresolved_locations: 20 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:60ad85f700000058/60ad85f700001094 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:1000458 occurs_in_label: melanocyte of skin status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000797 gene_product: MGI:MGI:1859179 gene_label: Irf3 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700001607 gene_product: MGI:MGI:97874 gene_label: Rb1 Mmus occurs_in: CL:0000138 occurs_in_label: chondrocyte status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000736 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000060 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: EMAPA:32760 occurs_in_label: bone marrow status: UNRESOLVED compartments: [] - activity_id: gomodel:60ad85f700000058/60ad85f700000723 gene_product: MGI:MGI:1201674 gene_label: Smad3 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700001580 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: EMAPA:19142 occurs_in_label: tibia status: UNRESOLVED compartments: [] - activity_id: gomodel:60ad85f700000058/60ad85f700000775 gene_product: MGI:MGI:2156367 gene_label: Tlr3 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000719 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000779 gene_product: MGI:MGI:2176882 gene_label: Tlr7 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000660 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000540 occurs_in_label: neuron status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000769 gene_product: MGI:MGI:97312 gene_label: Nfkb1 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000835 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000057 occurs_in_label: fibroblast status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000734 gene_product: MGI:MGI:1201674 gene_label: Smad3 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000789 gene_product: MGI:MGI:1859179 gene_label: Irf3 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000740 gene_product: MGI:MGI:98725 gene_label: Tgfb1 Mmus occurs_in: CL:0000235 occurs_in_label: macrophage status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700001556 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000066 occurs_in_label: epithelial cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000838 gene_product: MGI:MGI:88096 gene_label: Atf4 Mmus occurs_in: CL:0000057 occurs_in_label: fibroblast status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700001624 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000138 occurs_in_label: chondrocyte status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:60ad85f700000058/60ad85f700000063 gene_product: MGI:MGI:109349 gene_label: Atf2 Mmus occurs_in: CL:0000057 occurs_in_label: fibroblast status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. edges: [] - model: gomodel:60ad85f700000110 title: receptor signaling pathway via JAK-STAT via upd2-dome (D.mel) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:60ad85f700000110/60ad85f700000153 upstream_label: hop Dmel downstream: gomodel:60ad85f700000110/60ad85f700000175 downstream_label: Stat92E Dmel predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:60ad85f700000309 title: Notch signaling pathway via N-Dl (D.mel) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:60ad85f700000309/60ad85f700000327 gene_product: FB:FBgn0259984 gene_label: kuz Dmel occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: - upstream: gomodel:60ad85f700000309/60ad85f700000335 upstream_label: Psn Dmel downstream: gomodel:60ad85f700000309/60ad85f700000345 downstream_label: N Dmel predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - CELL_OUTER_MEMBRANE - EXTRACELLULAR - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:60ad85f700001013 title: Transcription Factor - Target Gene NR3C1 KCNAB2 n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:60ad85f700001013/69ea894900001521 gene_product: UniProtKB:Q13303 gene_label: KCNAB2 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:60ad85f700001013/60d5209a00000199 gene_product: CHEBI:36080 gene_label: protein occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:60ad85f700001013/60ad85f700001023 gene_product: UniProtKB:P04150 gene_label: NR3C1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:60ad85f700002621 title: Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:60ad85f700002621/60ad85f700002648 gene_product: CHEBI:36080 gene_label: protein occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:60ad85f700002621/69ea894900001541 gene_product: UniProtKB:P49641 gene_label: MAN2A2 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:60ad85f700002621/69ea894900001532 gene_product: UniProtKB:P07332 gene_label: FES Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:60ad85f700002621/60ad85f700002633 gene_product: UniProtKB:P04150 gene_label: NR3C1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:60ad85f700002621/69ea894900001556 gene_product: UniProtKB:P54132 gene_label: BLM Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:60ad85f700002621/69ea894900001550 gene_product: UniProtKB:P09958 gene_label: FURIN Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:613aae0000000338 title: TGM2 dopaminyltransferase activity towards Histone H3 (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:613aae0000000338/613aae0000000340 gene_product: UniProtKB:P21980 gene_label: TGM2 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:613aae0000000338/613aae0000000424 gene_product: UniProtKB:P21980 gene_label: TGM2 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:613aae0000000338/613aae0000000444 gene_product: UniProtKB:P68431 gene_label: H3C1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:613aae0000000885 title: PTPRM role in glucose transport activity through inhibition of CTNND1 (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:613aae0000000885/613aae0000000886 gene_product: UniProtKB:P28827 gene_label: PTPRM Hsap occurs_in: GO:0005911 occurs_in_label: cell-cell junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:613aae0000001005 title: Activation of RECQL5 by CDK1 leading to mitotic DNA replication activation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:613aae0000001005/613aae0000001006 gene_product: UniProtKB:O94762 gene_label: RECQL5 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: &id002 id: GO:0000228 label: nuclear chromosome - activity_id: gomodel:613aae0000001005/613aae0000001018 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0099182 occurs_in_label: presynaptic intermediate filament cytoskeleton status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:613aae0000001005/613aae0000001032 gene_product: UniProtKB:Q96NY9 gene_label: MUS81 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:617b481400000389 title: KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) n_activities: 7 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:617b481400000389/617b481400000400 gene_product: UniProtKB:Q92993 gene_label: KAT5 Hsap occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:617b481400000460 title: KAT5 involvement in DNA repair via homologous recombination (Human) n_activities: 10 n_causal_edges: 8 n_unresolved_locations: 7 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:617b481400000460/617b481400000468 gene_product: UniProtKB:Q8IYW5 gene_label: RNF168 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400000460/617b481400000482 gene_product: UniProtKB:Q05BQ5 gene_label: MBTD1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400000460/617b481400000461 gene_product: UniProtKB:Q92993 gene_label: KAT5 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400000460/617b481400000487 gene_product: UniProtKB:Q9H2F5 gene_label: EPC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400000460/617b481400000511 gene_product: UniProtKB:Q12888 gene_label: TP53BP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400000460/617b481400000753 gene_product: UniProtKB:Q05BQ5 gene_label: MBTD1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400000460/617b481400000475 gene_product: UniProtKB:Q12888 gene_label: TP53BP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:617b481400000672 title: KAT5 chromatin localization (Human) n_activities: 6 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:617b481400000672/617b481400000680 gene_product: UniProtKB:Q92993 gene_label: KAT5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:617b481400000672/617b481400000706 gene_product: UniProtKB:Q92993 gene_label: KAT5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:617b481400000672/617b481400000699 gene_product: UniProtKB:Q92993 gene_label: KAT5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:617b481400003575 title: Role of RNF169 in double-strand break repair upon DYRK1A activation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:617b481400003575/617b481400003584 gene_product: UniProtKB:Q8NCN4 gene_label: RNF169 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400003575/617b481400003589 gene_product: UniProtKB:Q96RL1 gene_label: UIMC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:617b481400003575/617b481400003582 gene_product: UniProtKB:Q12888 gene_label: TP53BP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:6197061700001485 title: Silencing of fetal hemoglobin by ZNF410 (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6197061700001485/6197061700001496 gene_product: UniProtKB:P69891 gene_label: HBG1 Hsap occurs_in: CL:0000232 occurs_in_label: erythrocyte status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:6197061700001485/6197061700001501 gene_product: UniProtKB:P69892 gene_label: HBG2 Hsap occurs_in: CL:0000232 occurs_in_label: erythrocyte status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:6197061700001485/6197061700001486 gene_product: UniProtKB:Q86VK4 gene_label: ZNF410 Hsap occurs_in: CL:0000764 occurs_in_label: erythroid lineage cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:6197061700001485/6197061700001506 gene_product: UniProtKB:Q14839 gene_label: CHD4 Hsap occurs_in: CL:0000764 occurs_in_label: erythroid lineage cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. edges: [] - model: gomodel:61e0e55600001225 title: Gluconeogenesis 1 (Mouse) n_activities: 17 n_causal_edges: 18 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:61e0e55600001225/61e0e55600001730 upstream_label: Slc25a10 Mmus downstream: gomodel:61e0e55600001225/61e0e55600001726 downstream_label: Mdh1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT - upstream: gomodel:61e0e55600001225/62f58d8800003911 upstream_label: Slc25a11 Mmus downstream: gomodel:61e0e55600001225/61e0e55600001726 downstream_label: Mdh1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:61f34dd300000787 title: IL23 signaling pathway (Human) n_activities: 7 n_causal_edges: 10 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:61f34dd300000787/62183af000000016 upstream_label: JAK2 Hsap downstream: gomodel:61f34dd300000787/62183af000000030 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:61f34dd300000787/62183af000000016 upstream_label: JAK2 Hsap downstream: gomodel:61f34dd300000787/62183af000000030 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:6205c24300000050 title: SIRT6 inactivation by lncPRESS1 RNA (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6205c24300000050/6205c24300000065 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6205c24300000050/6205c24300000058 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6205c24300000330 title: Microtubule polyglutamylation regulation (Human) n_activities: 9 n_causal_edges: 11 n_unresolved_locations: 8 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6205c24300000330/6205c24300001444 gene_product: UniProtKB:Q6ZTW0 gene_label: TPGS1 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300001410 gene_product: UniProtKB:Q96L34 gene_label: MARK4 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300000347 gene_product: UniProtKB:P27816 gene_label: MAP4 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300000453 gene_product: UniProtKB:Q15154 gene_label: PCM1 Hsap occurs_in: GO:0034451 occurs_in_label: centriolar satellite status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300001427 gene_product: UniProtKB:Q9H6J7 gene_label: CSTPP1 Hsap occurs_in: GO:0034451 occurs_in_label: centriolar satellite status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300001464 gene_product: UniProtKB:Q8IUZ0-4 gene_label: LRRC49 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300000331 gene_product: UniProtKB:O95922 gene_label: TTLL1 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL - activity_id: gomodel:6205c24300000330/6205c24300001454 gene_product: UniProtKB:Q68CL5 gene_label: TPGS2 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL edges: [] - model: gomodel:6205c24300001663 title: IL2 signaling pathway (Human) n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:6205c24300001663/6205c24300001751 upstream_label: JAK3 Hsap downstream: gomodel:6205c24300001663/6205c24300001760 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:6205c24300001663/6205c24300001744 upstream_label: JAK1 Hsap downstream: gomodel:6205c24300001663/627d95ee00000553 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:62183af000000536 title: DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62183af000000536/62183af000000547 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:62183af000000536/62183af000000557 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:62183af000000536/62183af000000537 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:622aace900000522 title: ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:622aace900000522/622aace900000542 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:622aace900000522/622aace900000523 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:622aace900000522/622aace900000574 gene_product: UniProtKB:Q9NWY4 gene_label: HPF1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:622aace900000522/622aace900000567 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:622aace900000522/622aace900000558 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:622aace900000522/622aace900000535 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:623d156d00000290 title: IL4-mediated signaling pathway (human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:623d156d00000290/623d156d00000309 upstream_label: JAK3 Hsap downstream: gomodel:623d156d00000290/626b20c100000122 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:623d156d00000290/623d156d00000305 upstream_label: JAK1 Hsap downstream: gomodel:623d156d00000290/623d156d00000325 downstream_label: STAT6 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:623d156d00000340 title: IL3-mediated signaling pathway (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:623d156d00000340/623d156d00000369 upstream_label: JAK2 Hsap downstream: gomodel:623d156d00000340/623d156d00000374 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:623d156d00000673 title: IL5-mediated signaling pathway (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:623d156d00000673/623d156d00000679 gene_product: UniProtKB:Q01344 gene_label: IL5RA Hsap occurs_in: CL:0000771 occurs_in_label: eosinophil status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:623d156d00000673/6246724f00000601 gene_product: UniProtKB:P42229 gene_label: STAT5A Hsap occurs_in: CL:0000771 occurs_in_label: eosinophil status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:623d156d00000673/6246724f00000610 gene_product: UniProtKB:P07948 gene_label: LYN Hsap occurs_in: CL:0000771 occurs_in_label: eosinophil status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. edges: [] - model: gomodel:623d156d00000817 title: Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) n_activities: 7 n_causal_edges: 10 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:623d156d00000817/623d156d00000818 gene_product: UniProtKB:P78527 gene_label: PRKDC Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:623d156d00000817/623d156d00000879 gene_product: UniProtKB:Q9NQR1 gene_label: KMT5A Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:623d156d00000817/623d156d00000827 gene_product: UniProtKB:Q9Y294 gene_label: ASF1A Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:623d156d00000817/623d156d00000870 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:623d156d00000817/623d156d00000836 gene_product: UniProtKB:Q96HA7 gene_label: TONSL Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:623d156d00000817/623d156d00000850 gene_product: UniProtKB:Q6ZRQ5 gene_label: MMS22L Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:6246724f00000675 title: IL7-mediated signaling pathway (Human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:6246724f00000675/6246724f00000731 upstream_label: JAK1 Hsap downstream: gomodel:6246724f00000675/65d7e4ac00000418 downstream_label: STAT1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:6246724f00000675/6246724f00000717 upstream_label: JAK3 Hsap downstream: gomodel:6246724f00000675/6246724f00000751 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:6246724f00000763 title: TSLP-mediated signaling pathway (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:6246724f00000763/6246724f00000779 upstream_label: JAK1 Hsap downstream: gomodel:6246724f00000763/6246724f00000785 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:6246724f00000763/6246724f00000782 upstream_label: JAK2 Hsap downstream: gomodel:6246724f00000763/6246724f00000785 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:6246724f00001921 title: ZDHHC20-ZDHHC9 Palmitoyltransferase activity of Sars-Cov-2 S protein (Human-Sars-Cov-2) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6246724f00001921/6246724f00001945 gene_product: UniProtKB:P0DTC2 gene_label: S protein Scov2 occurs_in: GO:0043655 occurs_in_label: host extracellular region status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:626b20c100000025 title: IL9-mediated signaling pathway (Human) n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:626b20c100000025/626b20c100000044 upstream_label: JAK3 Hsap downstream: gomodel:626b20c100000025/626b20c100000048 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:626b20c100000025/626b20c100000040 upstream_label: JAK1 Hsap downstream: gomodel:626b20c100000025/626b20c100000056 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:626b20c100000025/626b20c100000040 upstream_label: JAK1 Hsap downstream: gomodel:626b20c100000025/626b20c100000052 downstream_label: STAT1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:626b20c100000443 title: Regulation of gluconeogenesis by TOX4 (Mouse) n_activities: 5 n_causal_edges: 8 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:626b20c100000443/626b20c100000456 gene_product: MGI:MGI:1915389 gene_label: Tox4 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:626b20c100000443/626b20c100000468 gene_product: MGI:MGI:88494 gene_label: Creb1 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:626b20c100000443/626b20c100000444 gene_product: MGI:MGI:1890077 gene_label: Foxo1 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:626b20c100000681 title: IL10-mediated signaling pathway (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:626b20c100000681/626b20c100000712 upstream_label: JAK1 Hsap downstream: gomodel:626b20c100000681/626b20c100000721 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:626b20c100001212 title: IL11-mediated signaling pathway (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:626b20c100001212/626b20c100001633 upstream_label: JAK1 Hsap downstream: gomodel:626b20c100001212/626b20c100001653 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:627d95ee00000024 title: IL12-mediated signaling pathway (Human) n_activities: 8 n_causal_edges: 11 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:627d95ee00000024/62900b6400000205 upstream_label: JAK2 Hsap downstream: gomodel:627d95ee00000024/62900b6400000213 downstream_label: STAT4 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:627d95ee00000275 title: Heparan sulfate proteoglycan catabolic process (Mouse) n_activities: 15 n_causal_edges: 14 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:627d95ee00000275/627d95ee00000709 upstream_label: Sdc1 Mmus downstream: gomodel:627d95ee00000275/627d95ee00000529 downstream_label: Ctsl Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - LYSOSOME_LUMEN status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:627d95ee00000472 title: IL15 signaling pathway (Human) n_activities: 8 n_causal_edges: 8 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:627d95ee00000472/627d95ee00000530 upstream_label: JAK3 Hsap downstream: gomodel:627d95ee00000472/627d95ee00000566 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:627d95ee00000775 title: ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) n_activities: 8 n_causal_edges: 14 n_unresolved_locations: 7 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00000775/627d95ee00000824 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00000775/627d95ee00000795 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:627d95ee00000775/627d95ee00000806 gene_product: UniProtKB:Q9NWY4 gene_label: HPF1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00000775/627d95ee00000848 gene_product: UniProtKB:Q86WJ1-5 gene_label: CHD1L Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00000775/627d95ee00000785 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00000775/627d95ee00000817 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00000775/627d95ee00000841 gene_product: UniProtKB:Q86WJ1-5 gene_label: CHD1L Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:627d95ee00001139 title: Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00001139/627d95ee00001166 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:627d95ee00001242 title: Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) n_activities: 8 n_causal_edges: 10 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00001242/627d95ee00001305 gene_product: UniProtKB:P18615 gene_label: NELFE Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:627d95ee00001943 title: Activation of PARP1 activity by HPF1 during DNA repair (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00001943/627d95ee00001944 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00001943/627d95ee00001978 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00001943/627d95ee00001951 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00001943/627d95ee00001958 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00001943/627d95ee00001965 gene_product: UniProtKB:Q9NWY4 gene_label: HPF1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:627d95ee00001988 title: Regulation of Parp1 activity by Cgas, Setd7 and Riox1 (Mouse) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00001988/627d95ee00002019 gene_product: MGI:MGI:1340806 gene_label: Parp1 Mmus occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:627d95ee00002030 title: Activation of PARP2 activity by HPF1 during DNA repair (Human) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00002030/627d95ee00002031 gene_product: UniProtKB:Q9UGN5 gene_label: PARP2 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002030/627d95ee00002054 gene_product: UniProtKB:Q9NWY4 gene_label: HPF1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002030/627d95ee00002040 gene_product: UniProtKB:Q9UGN5 gene_label: PARP2 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002030/627d95ee00002047 gene_product: UniProtKB:Q9UGN5 gene_label: PARP2 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:627d95ee00002067 title: Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:627d95ee00002067/627d95ee00002098 gene_product: UniProtKB:Q8IW19 gene_label: APLF Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002067/627d95ee00002109 gene_product: UniProtKB:O75367 gene_label: MACROH2A1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002067/627d95ee00002091 gene_product: UniProtKB:Q8IW19 gene_label: APLF Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002067/627d95ee00002077 gene_product: UniProtKB:Q9UGN5 gene_label: PARP2 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002067/627d95ee00002084 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:627d95ee00002067/627d95ee00002068 gene_product: UniProtKB:Q9UGN5 gene_label: PARP2 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:62900b6400000076 title: Histone poly-ADP-ribosylation of histone H2B at Glu-35 by Parp1 that prevents phosphorylation at of histone H2B at Ser-36 by Prkaa1 (Mouse) n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62900b6400000076/62900b6400000084 gene_product: MGI:MGI:2145955 gene_label: Prkaa1 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62900b6400000076/62900b6400000077 gene_product: MGI:MGI:1340806 gene_label: Parp1 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62900b6400000076/62900b6400000093 gene_product: MGI:MGI:1913704 gene_label: Nmnat1 Mmus occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:62900b6400000999 title: IL19-mediated signaling pathway n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:62900b6400000999/62900b6400001652 upstream_label: JAK1 Hsap downstream: gomodel:62900b6400000999/62900b6400001658 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:62900b6400001630 title: PTEN in excitatory hippocampal synapse long-term depression (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62900b6400001630/62900b6400001705 gene_product: UniProtKB:P60484 gene_label: PTEN Hsap occurs_in: GO:0099092 occurs_in_label: postsynaptic density, intracellular component status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:62900b6400001630/62900b6400001636 gene_product: GO:0017146 gene_label: NMDA selective glutamate receptor complex occurs_in: GO:0099092 occurs_in_label: postsynaptic density, intracellular component status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:62900b6400001630/62900b6400001689 gene_product: UniProtKB:P78352 gene_label: DLG4 Hsap occurs_in: GO:0099092 occurs_in_label: postsynaptic density, intracellular component status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:62900b6400001630/62900b6400001715 gene_product: UniProtKB:P35222 gene_label: CTNNB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:62900b6400001749 title: ZDHHC7 Hsap regulates SCRIB in polarized cell differentiation (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62900b6400001749/62900b6400001763 gene_product: UniProtKB:Q14160 gene_label: SCRIB Hsap occurs_in: GO:0005911 occurs_in_label: cell-cell junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:62b4ffe300000504 title: 'Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:62b4ffe300000504/62b4ffe300000522 upstream_label: RIPK3 Hsap downstream: gomodel:62b4ffe300000504/62b4ffe300000706 downstream_label: MLKL Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:62b4ffe300000717 title: 'Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) ' n_activities: 6 n_causal_edges: 8 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:62b4ffe300000717/62b4ffe300000750 upstream_label: IFNB1 Hsap downstream: gomodel:62b4ffe300000717/62b4ffe300000826 downstream_label: IFIT3 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:62b4ffe300000717/62b4ffe300000750 upstream_label: IFNB1 Hsap downstream: gomodel:62b4ffe300000717/62b4ffe300000758 downstream_label: IFIT1 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:62b4ffe300000717/62b4ffe300000750 upstream_label: IFNB1 Hsap downstream: gomodel:62b4ffe300000717/62b4ffe300000880 downstream_label: IFIT2 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:62b4ffe300002385 title: Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300002385/654d809000002682 gene_product: UniProtKB:A0A0H2US87 gene_label: ospC3 SHIFL occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300002385/62b4ffe300002386 gene_product: UniProtKB:A0A0H2US87 gene_label: ospC3 SHIFL occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300003074 title: 'Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300003074/62b4ffe300003084 gene_product: UniProtKB:P17362 gene_label: OPG029 VACCW occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300003248 title: 'Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300003248/62b4ffe300003249 gene_product: UniProtKB:P56524 gene_label: HDAC4 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300003248/62b4ffe300003264 gene_product: UniProtKB:P52630 gene_label: STAT2 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:62b4ffe300003321 title: 'Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300003321/62b4ffe300003322 gene_product: UniProtKB:P07396 gene_label: OPG062 VACCW occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300003679 title: 'Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) ' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300003679/62b4ffe300004354 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300003679/62b4ffe300004335 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:62b4ffe300003747 title: ' Response to IFN-beta, leading to JAK-STAT activation (Human)' n_activities: 15 n_causal_edges: 17 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:62b4ffe300003747/62b4ffe300003944 upstream_label: TYK2 Hsap downstream: gomodel:62b4ffe300003747/62b4ffe300004006 downstream_label: STAT1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:62b4ffe300003747/62b4ffe300004140 upstream_label: TYK2 Hsap downstream: gomodel:62b4ffe300003747/62b4ffe300004187 downstream_label: STAT2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:62b4ffe300003747/62b4ffe300004047 upstream_label: JAK1 Hsap downstream: gomodel:62b4ffe300003747/62b4ffe300004006 downstream_label: STAT1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:62b4ffe300004857 title: Arginine ADP-riboxanation of CASP7 by by C.violaceum CopC blocks CASP7 activity and apoptosis (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300004857/62b4ffe300004858 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300004857/62b4ffe300004869 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300004892 title: Arginine ADP-riboxanation of CASP8 by by C.violaceum CopC blocks CASP8 activity and extrinsic apoptosis (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300004892/62b4ffe300004893 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300004892/62b4ffe300004905 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300004953 title: 'Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human) ' n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300004953/62b4ffe300004966 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300004953/62b4ffe300004954 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005060 title: 'Arginine ADP-riboxanation of CASP9 by by C.violaceum CopC that blocks CASP9 activity and intrinsic apoptosis (Human) ' n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005060/62b4ffe300005073 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300005060/62b4ffe300005061 gene_product: UniProtKB:Q7NWF2 gene_label: copC NCBITaxon:243365 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005140 title: 'Poxvirus-OPG188 inhibition of host cGAS-STING pathway (Human-Poxvirus) ' n_activities: 3 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005140/62b4ffe300005149 gene_product: UniProtKB:Q01225 gene_label: OPG188 VACCW occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005181 title: 'Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) ' n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005181/62b4ffe300005275 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300005181/62b4ffe300005231 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300005181/62b4ffe300005224 gene_product: UniProtKB:Q76QY7 gene_label: OPG003 VAR67 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005283 title: 'Poxvirus-OPG058 inhibition of host NF-kappa-B via CBP (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005283/62b4ffe300005309 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300005283/62b4ffe300005284 gene_product: UniProtKB:P68707 gene_label: OPG058 VACCW occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005342 title: 'Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005342/62b4ffe300005376 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300005342/62b4ffe300005363 gene_product: UniProtKB:P31037 gene_label: VACWR175 VACCW occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005389 title: 'Poxvirus-OPG184 inhibition of host NF-kappa-B via KPNA2 (Human-Poxvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005389/62b4ffe300005410 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62b4ffe300005389/62b4ffe300005397 gene_product: UniProtKB:P24768 gene_label: KBTB1 VACCW occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005437 title: Inhibition of the JAK-STAT pathway by S.flexneri OspC3 that blocks calcium-binding to calmodulin (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005437/62b4ffe300005438 gene_product: UniProtKB:A0A0H2US87 gene_label: ospC3 SHIFL occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005467 title: Inhibition of the JAK-STAT pathway by S.flexneri OspC1 that blocks calcium-binding to calmodulin (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005467/62b4ffe300005468 gene_product: UniProtKB:Q8VSJ7 gene_label: ospC1 SHIFL occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005506 title: 'Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) ' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005506/62b4ffe300005564 gene_product: UniProtKB:Q01220 gene_label: VACWR178 VACCW occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005623 title: 'HHV1-US3 inhibition of host TCR signaling via LAT (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005623/62b4ffe300005624 gene_product: UniProtKB:P04413 gene_label: US3 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005697 title: 'HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005697/62b4ffe300005698 gene_product: UniProtKB:P04413 gene_label: US3 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300005953 title: 'HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300005953/62b4ffe300005954 gene_product: UniProtKB:P04413 gene_label: US3 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300005953/62b4ffe300005992 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:62b4ffe300006001 title: 'HHV1-US3 inhibition of host IRF3 (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300006001/62b4ffe300006002 gene_product: UniProtKB:P04413 gene_label: US3 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62b4ffe300006001/62b4ffe300006081 gene_product: UniProtKB:Q14653 gene_label: IRF3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:62b4ffe300006258 title: 'HHV1-UL36 inhibition of host cGAS-STING pathway via STING (Human-Herpesvirus) ' n_activities: 3 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300006258/62b4ffe300006281 gene_product: UniProtKB:P10220 gene_label: UL36 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300006335 title: 'HHV1-UL37 inhibition of host cGAS-STING pathway via cGAS deamidation (Human-Herpesvirus) ' n_activities: 3 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300006335/62b4ffe300006336 gene_product: UniProtKB:P10221 gene_label: UL37 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62b4ffe300006376 title: 'HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62b4ffe300006376/62b4ffe300006377 gene_product: UniProtKB:P10221 gene_label: UL37 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62d0afa500000298 title: Gluconeogenesis 3 (Mouse) n_activities: 18 n_causal_edges: 20 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:62d0afa500000298/62f58d8800003890 upstream_label: Slc25a12 Mmus downstream: gomodel:62d0afa500000298/62d0afa500000304 downstream_label: Got1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT - upstream: gomodel:62d0afa500000298/62f58d8800003900 upstream_label: Slc25a11 Mmus downstream: gomodel:62d0afa500000298/62d0afa500000304 downstream_label: Got1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT - upstream: gomodel:62d0afa500000298/62d0afa500000337 upstream_label: Slc25a13 Mmus downstream: gomodel:62d0afa500000298/62d0afa500000304 downstream_label: Got1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:62e3212700001602 title: 'FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) ' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62e3212700001602/62e3212700001645 gene_product: UniProtKB:Q14653 gene_label: IRF3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:62e3212700001602/62e3212700001612 gene_product: UniProtKB:P03306-PRO_0000310975 gene_label: P03306-P3A NCBITaxon:12112 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62f58d8800000464 title: 'HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) ' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62f58d8800000464/62f58d8800000469 gene_product: UniProtKB:F5HF44 gene_label: UL145 HCMVM occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62f58d8800000841 title: Zdhhc2 in regulation of long-term synaptic potentiation via Akap5 (Mouse) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:62f58d8800000841/62f58d8800000881 upstream_label: Akap5 Mmus downstream: gomodel:62f58d8800000841/62f58d8800003493 downstream_label: Gria1 Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:62f58d8800000934 title: 'HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) ' n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62f58d8800000934/62f58d8800000938 gene_product: UniProtKB:P69726 gene_label: vpr NCBITaxon:11706 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62f58d8800001022 title: 'HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) ' n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62f58d8800001022/62f58d8800001066 gene_product: UniProtKB:Q69027 gene_label: X HBVCJ occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62f58d8800001680 title: 'Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli)' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:62f58d8800001680/62f58d8800001696 upstream_label: AHR Hsap downstream: gomodel:62f58d8800001680/62f58d8800001721 downstream_label: IL10RA Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:62f58d8800001680/62f58d8800001706 upstream_label: ARNT Hsap downstream: gomodel:62f58d8800001680/62f58d8800001721 downstream_label: IL10RA Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:62f58d8800004747 title: ZDHHC2 in regulation of long-term synaptic potentiation via AKAP5 (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:62f58d8800004747/62f58d8800004751 upstream_label: AKAP5 Hsap downstream: gomodel:62f58d8800004747/62f58d8800004755 downstream_label: GRIA1 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:62f58d8800004946 title: TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62f58d8800004946/62f58d8800004949 gene_product: UniProtKB:O75665 gene_label: OFD1 Hsap occurs_in: GO:0036064 occurs_in_label: ciliary basal body status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:62f58d8800004946/62f58d8800004947 gene_product: UniProtKB:O43164 gene_label: PJA2 Hsap occurs_in: GO:0036064 occurs_in_label: ciliary basal body status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:62f58d8800004946/62f58d8800004952 gene_product: UniProtKB:Q96DN5 gene_label: TBC1D31 Hsap occurs_in: GO:0036064 occurs_in_label: ciliary basal body status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:62f58d8800004946/62f58d8800004956 gene_product: UniProtKB:P17252 gene_label: PRKCA Hsap occurs_in: GO:0036064 occurs_in_label: ciliary basal body status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:62f58d8800005908 title: 'HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) ' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62f58d8800005908/62f58d8800005959 gene_product: UniProtKB:P14334 gene_label: US6 HCMVA occurs_in: GO:0044167 occurs_in_label: host cell endoplasmic reticulum membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:62f58d8800006929 title: Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) n_activities: 13 n_causal_edges: 13 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:62f58d8800006929/62f58d8800006941 gene_product: UniProtKB:P0DTD1-PRO_0000449623 gene_label: nsp5 Scov2 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:62f58d8800006929/62f58d8800006930 gene_product: UniProtKB:P0DTD1-PRO_0000449623 gene_label: nsp5 Scov2 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:632cf60a00000169 title: 'HHV1-ICP0 modulation of interferon production via MORC3 degradation (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:632cf60a00000169/632cf60a00000188 gene_product: UniProtKB:P08393 gene_label: ICP0 HHV11 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:632cf60a00000169/632cf60a00000181 gene_product: UniProtKB:Q14149 gene_label: MORC3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:632cf60a00000478 title: 'HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:632cf60a00000478/632cf60a00000512 gene_product: UniProtKB:P04487 gene_label: US11 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:632cf60a00000522 title: 'HHV1-US11 inhibition of autophagy via CASP8 cleavage (Human-Herpesvirus) ' n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:632cf60a00000522/632cf60a00000530 gene_product: UniProtKB:P04487 gene_label: US11 HHV11 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:6348a65d00000661 title: Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6348a65d00000661/6348a65d00000709 gene_product: UniProtKB:P18014 gene_label: ipaH7.8 SHIFL occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:6348a65d00000724 title: 'Regulation by IL22 and Reg3g of allergic airway inflammation. (Mouse) ' n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6348a65d00000724/6348a65d00000755 upstream_label: Stat3 Mmus downstream: gomodel:6348a65d00000724/6348a65d00000767 downstream_label: Reg3g Mmus predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:6348a65d00000724/6348a65d00000743 upstream_label: Il22ra1 Mmus downstream: gomodel:6348a65d00000724/6348a65d00000755 downstream_label: Stat3 Mmus predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6348a65d00000848 title: 'Regulation by IL22 and REG3A of allergic airway inflammation. (Human) ' n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6348a65d00000848/6348a65d00000861 upstream_label: STAT3 Hsap downstream: gomodel:6348a65d00000848/6348a65d00000867 downstream_label: REG3A Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:6348a65d00000848/6348a65d00000855 upstream_label: IL22RA1 Hsap downstream: gomodel:6348a65d00000848/6348a65d00000861 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6348a65d00001191 title: Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia. (Mouse) n_activities: 13 n_causal_edges: 8 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6348a65d00001191/6348a65d00001471 gene_product: MGI:MGI:98397 gene_label: Src Mmus occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:6348a65d00001191/6348a65d00001245 gene_product: MGI:MGI:1349444 gene_label: Haao Mmus occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:6348a65d00001191/6348a65d00001210 gene_product: MGI:MGI:2138151 gene_label: Kmo Mmus occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:6348a65d00001191/6348a65d00001235 gene_product: MGI:MGI:1918039 gene_label: Kynu Mmus occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:6348a65d00001191/6348a65d00001223 gene_product: MGI:MGI:96416 gene_label: Ido1 Mmus occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:6348a65d00001727 title: Negative regulation of inflammatory response to wounding by REG3A. (Human) n_activities: 9 n_causal_edges: 8 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6348a65d00001727/6348a65d00001753 upstream_label: EXTL3 Hsap downstream: gomodel:6348a65d00001727/6348a65d00001767 downstream_label: STAT3 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:6348a65d00001727/6348a65d00001791 upstream_label: MAPK9 Hsap downstream: gomodel:6348a65d00001727/6348a65d00001826 downstream_label: TNF Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:6348a65d00001727/6348a65d00001791 upstream_label: MAPK9 Hsap downstream: gomodel:6348a65d00001727/6348a65d00001816 downstream_label: IL6 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6348a65d00002174 title: USP44-mediated FOXP3 deubiquitination leading to regulatory T-cell differentiation (Human) n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6348a65d00002174/6348a65d00002192 upstream_label: TGFB1 Hsap downstream: gomodel:6348a65d00002174/6348a65d00002175 downstream_label: USP44 Hsap predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:6348a65d00002174/6348a65d00002192 upstream_label: TGFB1 Hsap downstream: gomodel:6348a65d00002174/6348a65d00002175 downstream_label: USP44 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - EXTRACELLULAR downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:6348a65d00002206 title: USP44-mediated stabilization of DDB2 to Facilitate Nucleotide Excision Repair (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6348a65d00002206/6348a65d00002207 gene_product: UniProtKB:Q9H0E7 gene_label: USP44 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6348a65d00002206/6348a65d00002216 gene_product: UniProtKB:Q92466 gene_label: DDB2 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6348a65d00002206/6348a65d00002224 gene_product: UniProtKB:Q01831 gene_label: XPC Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6348a65d00002236 title: USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6348a65d00002236/6348a65d00002238 gene_product: UniProtKB:Q9H0E7 gene_label: USP44 Hsap occurs_in: GO:0072686 occurs_in_label: mitotic spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:6348a65d00002236/6348a65d00002247 gene_product: UniProtKB:Q12834 gene_label: CDC20 Hsap occurs_in: GO:0007094 occurs_in_label: mitotic spindle assembly checkpoint signaling status: UNRESOLVED compartments: [] edges: [] - model: gomodel:6348a65d00002600 title: Negative regulation of white adipogenesis by OVOL2. (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6348a65d00002600/6348a65d00002612 upstream_label: CEBPA Hsap downstream: gomodel:6348a65d00002600/6348a65d00002853 downstream_label: SLC2A4 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:635b1e3e00001811 title: The NLRP3 inflammasome (Human) n_activities: 14 n_causal_edges: 14 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:635b1e3e00001811/635b1e3e00001821 gene_product: UniProtKB:Q96P20 gene_label: NLRP3 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:635b1e3e00001811/635b1e3e00001959 gene_product: UniProtKB:Q8TDX7 gene_label: NEK7 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:635b1e3e00002003 title: Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) n_activities: 6 n_causal_edges: 7 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:635b1e3e00002003/635b1e3e00002138 gene_product: UniProtKB:I6WXK4 gene_label: ptpB NCBITaxon:83332 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:635b1e3e00002003/635b1e3e00002149 gene_product: UniProtKB:I6WXK4 gene_label: ptpB NCBITaxon:83332 occurs_in: GO:0020002 occurs_in_label: host cell plasma membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:635b1e3e00002003/635b1e3e00002129 gene_product: UniProtKB:I6WXK4 gene_label: ptpB NCBITaxon:83332 occurs_in: GO:0020002 occurs_in_label: host cell plasma membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:635b1e3e00002004 title: Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:635b1e3e00002004/635b1e3e00002009 gene_product: UniProtKB:Q96P20 gene_label: NLRP3 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:635b1e3e00002287 title: Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Mouse) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:635b1e3e00002287/635b1e3e00002311 gene_product: MGI:MGI:2180337 gene_label: Zar1 Mmus occurs_in: GO:0035770 occurs_in_label: ribonucleoprotein granule status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:635b1e3e00002327 title: CSNK1A1 inhibits formation of the NLRP3 inflammasome by mediating phosphorylation of NLRP3, inhibiting interaction betweeN NLRP3 and NEK7 (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:635b1e3e00002327/635b1e3e00002328 gene_product: UniProtKB:Q8TDX7 gene_label: NEK7 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:635b1e3e00002327/635b1e3e00002339 gene_product: UniProtKB:Q96P20 gene_label: NLRP3 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:635b1e3e00002404 title: Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:635b1e3e00002404/635b1e3e00002416 gene_product: UniProtKB:Q86SH2 gene_label: ZAR1 Hsap occurs_in: GO:0035770 occurs_in_label: ribonucleoprotein granule status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:636d9ce800001192 title: DCAF12 controls MOV10 during T cell activation. (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:636d9ce800001192/636d9ce800001208 gene_product: UniProtKB:Q9HCE1 gene_label: MOV10 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:636d9ce800001222 title: DCAF12 controls MOV10 during spermatogeneis. (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:636d9ce800001222/636d9ce800001229 gene_product: UniProtKB:Q9HCE1 gene_label: MOV10 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:63a86a8600001248 title: TRIM3-mediated ubiquitination of TLR3 leading to TLR3 activation (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:63a86a8600001248/63a86a8600001257 upstream_label: TRIM3 Hsap downstream: gomodel:63a86a8600001248/63a86a8600001250 downstream_label: TLR3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:63a86a8600001780 title: GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63a86a8600001780/6796b94c00005147 gene_product: UniProtKB:P04578-PRO_0000038427 gene_label: env-SU NCBITaxon:11706 occurs_in: GO:0020002 occurs_in_label: host cell plasma membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:63a86a8600001865 title: Irgb10/Gm12250 mediates disruption of the pathogen membrane, liberating ligands that are detected by inflammasomes (Mouse) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63a86a8600001865/63a86a8600001911 gene_product: MGI:MGI:2429943 gene_label: Gbp5 Mmus occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:63a86a8600001865/63a86a8600001900 gene_product: MGI:MGI:102772 gene_label: Gbp2 Mmus occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:63a86a8600001865/63a86a8600001866 gene_product: MGI:MGI:3649299 gene_label: Gm12250 Mmus occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:63a86a8600001865/63a86a8600001873 gene_product: MGI:MGI:3649299 gene_label: Gm12250 Mmus occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:63c0ac2b00000331 title: IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63c0ac2b00000331/63c0ac2b00000332 gene_product: UniProtKB:Q8VSC3 gene_label: ipaH9.8 SHIFL occurs_in: GO:0044164 occurs_in_label: host cell cytosol status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:63c0ac2b00000464 title: Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63c0ac2b00000464/63c0ac2b00000474 gene_product: UniProtKB:Q9Y2E6 gene_label: DTX4 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:63c0ac2b00000464/63c0ac2b00000465 gene_product: UniProtKB:Q96MT8 gene_label: CEP63 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:63c0ac2b00000464/63c0ac2b00000494 gene_product: UniProtKB:A0A024B7W1 gene_label: A0A024B7W1 NCBITaxon:2043570 occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:63c0ac2b00000547 title: Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63c0ac2b00000547/63c0ac2b00000568 gene_product: UniProtKB:Q2FVK1 gene_label: hlgB STAA8 occurs_in: GO:0044165 occurs_in_label: host cell endoplasmic reticulum status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:63c0ac2b00001143 title: IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) n_activities: 8 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:63c0ac2b00001143/641ce4dc00000633 upstream_label: ZDHHC5 Hsap downstream: gomodel:63c0ac2b00001143/63c0ac2b00001235 downstream_label: SQSTM1 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:63c0ac2b00001634 title: DCAF13 supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting PTEN polyubiquitination and degradation. (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63c0ac2b00001634/63c0ac2b00001645 gene_product: UniProtKB:P60484 gene_label: PTEN Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:63c0ac2b00002148 title: IFFO1 immobilizes broken DNA for reparation (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63c0ac2b00002148/63c0ac2b00002152 gene_product: UniProtKB:Q13426 gene_label: XRCC4 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:63c0ac2b00002148/63c0ac2b00002149 gene_product: UniProtKB:Q0D2I5 gene_label: IFFO1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:63d320cd00000225 title: Activation of the AIM2 inflammasome in response to DNA damage (Mouse) n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63d320cd00000225/63d320cd00000226 gene_product: MGI:MGI:2686159 gene_label: Aim2 Mmus occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:63d320cd00000225/63d320cd00000298 gene_product: MGI:MGI:2686159 gene_label: Aim2 Mmus occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:63d320cd00000317 title: Activation of the AIM2 inflammasome in neural cells shapes neurodevelopment (Mouse) n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63d320cd00000317/63d320cd00000352 gene_product: MGI:MGI:2686159 gene_label: Aim2 Mmus occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:63d320cd00000317/63d320cd00000318 gene_product: MGI:MGI:2686159 gene_label: Aim2 Mmus occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:63e5937500000487 title: Negative regulation of inflammatory response to wounding by Reg3g. (Mouse) n_activities: 10 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:63e5937500000487/63e5937500000501 upstream_label: Extl3 Mmus downstream: gomodel:63e5937500000487/63e5937500000508 downstream_label: Stat3 Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:63e5937500000487/63e5937500000520 upstream_label: Mapk9 Mmus downstream: gomodel:63e5937500000487/63e5937500000532 downstream_label: Il6 Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:63e5937500000487/63e5937500000520 upstream_label: Mapk9 Mmus downstream: gomodel:63e5937500000487/63e5937500000537 downstream_label: Tnf Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:63f809ec00000027 title: Trans-negative regulation of Sars-CoV-2 viral entry into host cell by LRRC15. (Human-Sars-CoV-2) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63f809ec00000027/64b9cb1500000221 gene_product: UniProtKB:P0DTC2 gene_label: S protein Scov2 occurs_in: GO:0043655 occurs_in_label: host extracellular region status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:63f809ec00001308 title: EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63f809ec00001308/63f809ec00001328 gene_product: UniProtKB:P03211 gene_label: EBNA1 NCBITaxon:10377 occurs_in: GO:0075341 occurs_in_label: host cell PML body status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:63f809ec00001358 title: ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:63f809ec00001358/63f809ec00001362 gene_product: UniProtKB:P03206 gene_label: BZLF1 NCBITaxon:10377 occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:63f809ec00001358/63f809ec00001386 gene_product: UniProtKB:P67870 gene_label: CSNK2B Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:63f809ec00001358/63f809ec00001375 gene_product: UniProtKB:P05412 gene_label: JUN Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:63f809ec00001358/63f809ec00001359 gene_product: UniProtKB:Q96B23 gene_label: ARK2N Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:63f809ec00001734 title: TGF-beta-mediated inhibition of TAF7 via TRIM26 n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:63f809ec00001734/63f809ec00001735 upstream_label: TGFB1 Hsap downstream: gomodel:63f809ec00001734/63f809ec00001742 downstream_label: SMAD3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:6413ac9800000654 title: MYD88-independent TLR4 signaling pathway leading to interferon production (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6413ac9800000654/6413ac9800000737 gene_product: UniProtKB:Q14653 gene_label: IRF3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:641ce4dc00000050 title: NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) n_activities: 17 n_causal_edges: 21 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:641ce4dc00000050/641ce4dc00000201 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:641ce4dc00000050/641ce4dc00000193 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:641ce4dc00000214 title: NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) n_activities: 16 n_causal_edges: 20 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:641ce4dc00000214/641ce4dc00000281 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:641ce4dc00000214/641ce4dc00000277 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:641ce4dc00000914 title: Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:641ce4dc00000914/641ce4dc00000977 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:641ce4dc00000914/641ce4dc00000981 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:641ce4dc00001047 title: Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:641ce4dc00001047/641ce4dc00001064 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:641ce4dc00001047/641ce4dc00001068 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6438950a00000032 title: Human metapneumovirus M2-2 inhibition of IRF7 (Human-Metapneumovirus) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6438950a00000032/6438950a00000033 gene_product: UniProtKB:Q92985 gene_label: IRF7 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6438950a00000074 title: 'Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) ' n_activities: 6 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6438950a00000074/6438950a00000104 gene_product: UniProtKB:Q6WB96 gene_label: M2 NCBITaxon:694067 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:6438950a00000074/6438950a00000114 gene_product: UniProtKB:Q6WB96 gene_label: M2 NCBITaxon:694067 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:6438950a00000714 title: Regulation of ion transport in the distal nephron by WNK4 (Human) n_activities: 4 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6438950a00000714/6438950a00000715 gene_product: UniProtKB:Q96J92 gene_label: WNK4 Hsap occurs_in: GO:0005923 occurs_in_label: bicellular tight junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:6438950a00000766 title: Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 1 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6438950a00000766/6438950a00000780 gene_product: UniProtKB:Q96J92 gene_label: WNK4 Hsap occurs_in: GO:0005923 occurs_in_label: bicellular tight junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: - upstream: gomodel:6438950a00000766/6438950a00000826 upstream_label: AGT Hsap downstream: gomodel:6438950a00000766/6438950a00000816 downstream_label: PRKCA Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6446bfcb00001208 title: Thiamine diphosphate biosynthetic process 1 (Mouse) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6446bfcb00001208/6446bfcb00001214 upstream_label: Tpk1 Mmus downstream: gomodel:6446bfcb00001208/6446bfcb00001217 downstream_label: Slc25a19 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:6446bfcb00001243 title: Thiamine diphosphate biosynthetic process 2 (Mouse) n_activities: 5 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6446bfcb00001243/6446bfcb00001260 upstream_label: Thtpa Mmus downstream: gomodel:6446bfcb00001243/6446bfcb00001252 downstream_label: Slc25a19 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:645d887900000340 title: Coenzyme A biosynthetic process 1 (Mouse) n_activities: 10 n_causal_edges: 10 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 2 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:645d887900000340/645d887900000381 upstream_label: Pank2 Mmus downstream: gomodel:645d887900000340/645d887900000374 downstream_label: Ppcs Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:645d887900000340/645d887900000384 upstream_label: Slc5a6 Mmus downstream: gomodel:645d887900000340/645d887900000381 downstream_label: Pank2 Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:645d887900000671 title: Osteocalcin (bglap) hormone produced by osteoblasts binds Gprc6a receptor and regulates testosterone biosynthesis and male fertility (Mouse). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:645d887900000671/645d887900000691 upstream_label: Gprc6a Mmus downstream: gomodel:645d887900000671/645d887900000699 downstream_label: Creb1 Mmus predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:645d887900000999 title: BMP7 signaling leading to osteoblast differentiation (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: - activity_id: gomodel:645d887900000999/645d887900001027 gene_product: UniProtKB:Q99717 gene_label: SMAD5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: - upstream: gomodel:645d887900000999/66e382fb00001905 upstream_label: ACVR1 Hsap downstream: gomodel:645d887900000999/66e382fb00002012 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmp_receptor_engagement downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:645d887900000999/66e382fb00001905 upstream_label: ACVR1 Hsap downstream: gomodel:645d887900000999/66e382fb00002029 downstream_label: SMAD9 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmp_receptor_engagement downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:645d887900001077 title: Cell type specific, p53-independent mitotic G2 DNA damage checkpoint signaling mediated by CREB3L1 in astrocytes. (Mouse) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:645d887900001077/645d887900001360 upstream_label: Mbtps2 Mmus downstream: gomodel:645d887900001077/645d887900001120 downstream_label: Creb3l1 Mmus predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - GOLGI_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:645d887900001323 title: 14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:645d887900001323/645d887900001339 gene_product: UniProtKB:Q8NHG8 gene_label: ZNRF2 Hsap occurs_in: GO:0043231 occurs_in_label: intracellular membrane-bounded organelle status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:645d887900001795 title: BMP2 signaling pathway (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:645d887900001795/645d887900001803 upstream_label: BMPR1A Hsap downstream: gomodel:645d887900001795/646ff70100002392 downstream_label: SMAD9 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:645d887900001795/645d887900001803 upstream_label: BMPR1A Hsap downstream: gomodel:645d887900001795/646ff70100002376 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:645d887900001795/645d887900001803 upstream_label: BMPR1A Hsap downstream: gomodel:645d887900001795/646ff70100002384 downstream_label: SMAD5 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:646ff70100000049 title: Antibacterial innate immune response to muramyl dipeptide. (Human) n_activities: 4 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:646ff70100000049/646ff70100000050 upstream_label: tlr2_tlr6_human Hsap downstream: gomodel:646ff70100000049/646ff70100000093 downstream_label: NFKB1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:646ff70100002308 title: SMAD6 arginine methylation inhibits SMAD1 signaling (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:646ff70100002308/646ff70100002309 upstream_label: BMP4 Hsap downstream: gomodel:646ff70100002308/646ff70100002317 downstream_label: PRMT1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:646ff70100005032 title: HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:646ff70100005032/646ff70100005076 gene_product: UniProtKB:F5HGQ8 gene_label: UL138 HCMVM occurs_in: GO:0044178 occurs_in_label: host cell Golgi membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:648d0dc100000022 title: SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Mouse) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:648d0dc100000022/6494e2e900002499 upstream_label: Cebpa Mmus downstream: gomodel:648d0dc100000022/6494e2e900002515 downstream_label: Lep Mmus predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:6494e2e900000134 title: Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) n_activities: 6 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6494e2e900000134/6494e2e900000144 gene_product: UniProtKB:Q92985 gene_label: IRF7 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6494e2e900001856 title: Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). n_activities: 8 n_causal_edges: 8 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 2 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6494e2e900001856/6494e2e900001873 upstream_label: OMA1 Hsap downstream: gomodel:6494e2e900001856/6494e2e900001857 downstream_label: DELE1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_OUTER_MEMBRANE - upstream: gomodel:6494e2e900001856/6494e2e900001873 upstream_label: OMA1 Hsap downstream: gomodel:6494e2e900001856/6494e2e900001857 downstream_label: DELE1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_OUTER_MEMBRANE - model: gomodel:6494e2e900002018 title: Glyceraldehyde-3-phosphate biosynthetic process 1 (Mouse) n_activities: 11 n_causal_edges: 10 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6494e2e900002018/6494e2e900002029 upstream_label: Slc25a10 Mmus downstream: gomodel:6494e2e900002018/6494e2e900002026 downstream_label: Mdh1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:6494e2e900002525 title: SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6494e2e900002525/6494e2e900002572 upstream_label: CEBPA Hsap downstream: gomodel:6494e2e900002525/6494e2e900002588 downstream_label: LEP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:64d5781900002033 title: Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:64d5781900002033/64d5781900002034 upstream_label: INS Hsap downstream: gomodel:64d5781900002033/64d5781900002041 downstream_label: PRKCI Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CYTOSOL status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:64d5781900002076 title: Role of ARF6 in CD36 localization to the plasma membrane (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:64d5781900002076/64d5781900002093 upstream_label: ARF6 Hsap downstream: gomodel:64d5781900002076/64d5781900002103 downstream_label: CD36 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:64e7eefa00000404 title: TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:64e7eefa00000404/64e7eefa00002048 gene_product: UniProtKB:Q92547 gene_label: TOPBP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:64e7eefa00000404/64e7eefa00000405 gene_product: UniProtKB:Q9BSD3 gene_label: RHNO1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:64e7eefa00000404/64e7eefa00000423 gene_product: UniProtKB:O75417 gene_label: POLQ Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65039e8700000010 title: Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700000010/65039e8700000021 gene_product: UniProtKB:Q14676 gene_label: MDC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000010/65039e8700000033 gene_product: UniProtKB:Q92547 gene_label: TOPBP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65039e8700000055 title: Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700000055/65039e8700000091 gene_product: UniProtKB:Q8IYW5 gene_label: RNF168 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000055/65039e8700000080 gene_product: UniProtKB:Q92547 gene_label: TOPBP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000055/65039e8700000063 gene_product: UniProtKB:Q92547 gene_label: TOPBP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000055/65039e8700000098 gene_product: UniProtKB:Q12888 gene_label: TP53BP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65039e8700000123 title: ATR autophosphorylation leads to interaction with TOPBP1 and ATR activation (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700000123/65039e8700000124 gene_product: UniProtKB:Q13535 gene_label: ATR Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000123/65039e8700000145 gene_product: UniProtKB:Q13535 gene_label: ATR Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000123/65039e8700000136 gene_product: UniProtKB:Q92547 gene_label: TOPBP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65039e8700000196 title: HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). n_activities: 9 n_causal_edges: 8 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700000196/65039e8700000242 gene_product: GO:0005662 gene_label: DNA replication factor A complex occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000196/65039e8700000215 gene_product: UniProtKB:O43719 gene_label: HTATSF1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000196/65039e8700000397 gene_product: UniProtKB:P27694 gene_label: RPA1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000196/65039e8700000228 gene_product: UniProtKB:Q92547 gene_label: TOPBP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65039e8700000196/65039e8700000250 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65039e8700000921 title: RNF170-mediated ubiquitination of TLR3 leading to TLR3 degradation (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 1 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65039e8700000921/65039e8700000951 upstream_label: RNF170 Hsap downstream: gomodel:65039e8700000921/65039e8700000922 downstream_label: TLR3 Hsap predicate: RO:0002630 predicate_label: directly negatively regulates direct: true upstream_compartments: - ER_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - ER_MEMBRANE - model: gomodel:65039e8700000967 title: Kaposi herpesvirus vIRF-1 inhibition of SIRT6 by preventing its deubiquitination (Human-Herpesvirus) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700000967/65039e8700000989 gene_product: UniProtKB:Q8N6T7 gene_label: SIRT6 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:65039e8700000967/65039e8700000968 gene_product: UniProtKB:F5HF68 gene_label: vIRF-1 NCBITaxon:868565 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:65039e8700001110 title: TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700001110/65039e8700001111 gene_product: UniProtKB:Q86WT6 gene_label: TRIM69 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65039e8700001110/65039e8700001130 gene_product: UniProtKB:Q13188 gene_label: STK3 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65039e8700001110/65039e8700001138 gene_product: UniProtKB:P51955 gene_label: NEK2 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65039e8700001110/65039e8700001118 gene_product: UniProtKB:P53350 gene_label: PLK1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:65039e8700001188 title: KIF11 ubiquitination leading to mitotic spindle assembly (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65039e8700001188/65039e8700001198 gene_product: UniProtKB:Q9ULW0 gene_label: TPX2 Hsap occurs_in: GO:0005819 occurs_in_label: spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:65039e8700001188/65039e8700001208 gene_product: UniProtKB:P52732 gene_label: KIF11 Hsap occurs_in: GO:0005819 occurs_in_label: spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:65039e8700001188/65039e8700001189 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005819 occurs_in_label: spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:65288b2200000062 title: GPR174 signaling pathway (Human) n_activities: 5 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65288b2200000062/65288b2200000090 upstream_label: PRKACA Hsap downstream: gomodel:65288b2200000062/65288b2200000103 downstream_label: IL2 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:65288b2200000194 title: STING1 acts as a proton channel and promotes autophagosome assembly (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65288b2200000194/65288b2200000488 upstream_label: STING1 Hsap downstream: gomodel:65288b2200000194/65288b2200000289 downstream_label: ATG5 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - GOLGI_MEMBRANE downstream_compartments: - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:65288b2200001218 title: USP9X-TRIM32 modulation of IQCB1 during G1-S (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65288b2200001218/65288b2200001254 gene_product: UniProtKB:Q15051 gene_label: IQCB1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65288b2200001218/65288b2200001219 gene_product: UniProtKB:Q93008 gene_label: USP9X Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65288b2200001218/65288b2200001230 gene_product: UniProtKB:Q15051 gene_label: IQCB1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65288b2200001218/65288b2200001240 gene_product: UniProtKB:Q13049 gene_label: TRIM32 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:65288b2200001267 title: 'USP9X-TRIM32 modulation of IQCB1 during G2-M (Human) ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65288b2200001267/65288b2200001268 gene_product: UniProtKB:Q13049 gene_label: TRIM32 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65288b2200001267/65288b2200001277 gene_product: UniProtKB:Q15051 gene_label: IQCB1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:65288b2200001267/65288b2200001289 gene_product: UniProtKB:Q9H992 gene_label: MARCHF7 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:653b0ce600000016 title: Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) n_activities: 9 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:653b0ce600000016/653b0ce600000033 upstream_label: JAK1 Hsap downstream: gomodel:653b0ce600000016/653b0ce600000036 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:653b0ce600000202 title: BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:653b0ce600000202/653b0ce600000217 gene_product: UniProtKB:Q15059 gene_label: BRD3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:653b0ce600000202/653b0ce600000203 gene_product: UniProtKB:Q09472 gene_label: EP300 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:653b0ce600000202/653b0ce600000210 gene_product: UniProtKB:Q15059 gene_label: BRD3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:653b0ce600001230 title: 'KSHV-ORF57 inhibition of host PKR (Human-HHV8) ' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:653b0ce600001230/653b0ce600001231 gene_product: UniProtKB:Q2HR75 gene_label: ORF57 NCBITaxon:868565 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:653b0ce600001283 title: 'KSHV-ORF57 inhibition of host P-body formation (Human-HHV8) ' n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:653b0ce600001283/653b0ce600001391 gene_product: UniProtKB:Q2HR75 gene_label: ORF57 NCBITaxon:868565 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:653b0ce600001285 title: 'KSHV-ORF37 inhibition of host inflammasome activation via AIM2 (Human-HHV8) ' n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:653b0ce600001285/653b0ce600001381 gene_product: UniProtKB:Q2HR95 gene_label: ORF37 NCBITaxon:868565 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:654d809000002780 title: Early endosome to recycling endosome transport by the FIP3-Rab11 complex (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:654d809000002780/654d809000002812 gene_product: UniProtKB:Q9Y6G9 gene_label: DYNC1LI1 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL edges: [] - model: gomodel:654d809000002825 title: Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 3 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:654d809000002825/65692e7e00001102 gene_product: UniProtKB:Q9H8V3 gene_label: ECT2 Hsap occurs_in: GO:0030496 occurs_in_label: midbody status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:654d809000002825/65692e7e00001063 gene_product: UniProtKB:Q9H0H5 gene_label: RACGAP1 Hsap occurs_in: GO:0030496 occurs_in_label: midbody status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:65692e7e00001542 title: Inhibition of IL17 signaling by USP25 via TRAF6 (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65692e7e00001542/65692e7e00001544 upstream_label: IL17A Hsap downstream: gomodel:65692e7e00001542/65692e7e00001567 downstream_label: TRAF3IP2 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:65692e7e00001822 title: RNF115 inhibition of TLR transport to cell surface (Human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65692e7e00001822/657ba49f00000114 upstream_label: RAB13 Hsap downstream: gomodel:65692e7e00001822/657ba49f00000122 downstream_label: TLR4 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:65692e7e00001822/657ba49f00000094 upstream_label: GDI1 Hsap downstream: gomodel:65692e7e00001822/657ba49f00000114 downstream_label: RAB13 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:65a1f4f800000391 title: Phosphorylation of RAD17 by ATM promotes recruitment of NBN and MRN complex to DNA damage sites (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800000391/65a1f4f800000407 gene_product: UniProtKB:O75943 gene_label: RAD17 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000391/65a1f4f800000417 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800000428 title: Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800000428/65a1f4f800000439 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000428/65a1f4f800000452 gene_product: UniProtKB:Q14676 gene_label: MDC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000428/65a1f4f800000472 gene_product: UniProtKB:Q14676 gene_label: MDC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800000487 title: 'Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human). ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800000487/65a1f4f800000527 gene_product: UniProtKB:P16104 gene_label: H2AX Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000487/65a1f4f800000536 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800000553 title: Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800000553/65a1f4f800000554 gene_product: UniProtKB:Q96FA3 gene_label: PELI1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000553/65a1f4f800000578 gene_product: UniProtKB:P16104 gene_label: H2AX Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000553/65a1f4f800000589 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800000673 title: Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800000673/65a1f4f800000708 gene_product: UniProtKB:Q8IYW5 gene_label: RNF168 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000673/65a1f4f800000696 gene_product: UniProtKB:Q8WYQ5 gene_label: DGCR8 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800000855 title: Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). n_activities: 9 n_causal_edges: 10 n_unresolved_locations: 8 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800000855/65a1f4f800000902 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800000987 gene_product: UniProtKB:Q92878 gene_label: RAD50 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800000979 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800002009 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800000913 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800000873 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800000890 gene_product: GO:0030870 gene_label: Mre11 complex occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800000855/65a1f4f800000971 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001029 title: SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001029/65a1f4f800001033 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001029/65a1f4f800001042 gene_product: GO:0030870 gene_label: Mre11 complex occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001029/65a1f4f800001065 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001127 title: Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001127/65a1f4f800001202 gene_product: UniProtKB:Q14676 gene_label: MDC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001127/65a1f4f800001151 gene_product: UniProtKB:Q14676 gene_label: MDC1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001127/65a1f4f800001138 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001127/65a1f4f800001191 gene_product: UniProtKB:O76064 gene_label: RNF8 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001246 title: Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). n_activities: 8 n_causal_edges: 8 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001246/65a1f4f800001296 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001246/65a1f4f800001268 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001246/66c7d41500001327 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001246/65a1f4f800001288 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001246/65a1f4f800001256 gene_product: GO:0030870 gene_label: Mre11 complex occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001380 title: RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001380/65a1f4f800001465 gene_product: UniProtKB:Q99708 gene_label: RBBP8 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001380/65a1f4f800001449 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001380/65a1f4f800001430 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001380/65a1f4f800001422 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001566 title: Methylation of MRE11 by PRMT1 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001566/65a1f4f800001588 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001668 title: Methylation of TP53BP1 by PRMT1 in response to DNA damage promotes double-strand break repair via nonhomologous end joining (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001668/65a1f4f800001716 gene_product: UniProtKB:Q12888 gene_label: TP53BP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800001740 title: 'Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human). ' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800001740/65a1f4f800001782 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800001740/65a1f4f800001790 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800002022 title: Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800002022/65a1f4f800002064 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800002142 title: DYNLL1 binds to MRE11 to limit DNA end resection (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800002142/65a1f4f800002151 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002142/65a1f4f800002207 gene_product: UniProtKB:P63167 gene_label: DYNLL1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002142/65a1f4f800002143 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002142/65a1f4f800002238 gene_product: UniProtKB:Q12888 gene_label: TP53BP1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800002442 title: MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800002442/65a1f4f800002452 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002442/65a1f4f800002460 gene_product: UniProtKB:P49959 gene_label: MRE11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002442/65a1f4f800002443 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800002560 title: Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800002560/65a1f4f800002561 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002560/65a1f4f800002570 gene_product: GO:0030870 gene_label: Mre11 complex occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002560/65a1f4f800002582 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002560/65a1f4f800002593 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002560/65a1f4f800002645 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800002665 title: Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800002665/65a1f4f800002675 gene_product: GO:0030870 gene_label: Mre11 complex occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002665/65a1f4f800002687 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002665/65a1f4f800002712 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002665/65a1f4f800002666 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002665/65a1f4f800002698 gene_product: UniProtKB:Q13315 gene_label: ATM Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65a1f4f800002884 title: Phosphorylation of NBN regulates DNA repair choice at telomes (Human). n_activities: 6 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65a1f4f800002884/65a1f4f800002912 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0000781 occurs_in_label: chromosome, telomeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002884/65a1f4f800002885 gene_product: UniProtKB:O60934 gene_label: NBN Hsap occurs_in: GO:0000781 occurs_in_label: chromosome, telomeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002884/65a1f4f800002904 gene_product: UniProtKB:Q15554 gene_label: TERF2 Hsap occurs_in: GO:0000781 occurs_in_label: chromosome, telomeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65a1f4f800002884/65a1f4f800002921 gene_product: UniProtKB:Q15554 gene_label: TERF2 Hsap occurs_in: GO:0000781 occurs_in_label: chromosome, telomeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65bc474400000029 title: ZDHHC4-mediated palmitoylation of MAVS via CPT1A (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65bc474400000029/65bc474400000030 upstream_label: ZDHHC4 Hsap downstream: gomodel:65bc474400000029/65bc474400000037 downstream_label: MAVS Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:65bc474400000029/65bc474400000047 upstream_label: CPT1A Hsap downstream: gomodel:65bc474400000029/65bc474400000030 downstream_label: ZDHHC4 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:65bc474400000069 title: Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65bc474400000069/65bc474400000081 gene_product: UniProtKB:Q15910 gene_label: EZH2 Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65bc474400001510 title: KDM1A acetylation by KAT8 inhibits epithelial to mesenchymal transition (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65bc474400001510/65bc474400001521 gene_product: UniProtKB:O60341 gene_label: KDM1A Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:65bc474400001544 title: Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:65bc474400001544/65bc474400001575 upstream_label: ATF4 Hsap downstream: gomodel:65bc474400001544/65bc474400001545 downstream_label: GDF15 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:65bc474400001544/65bc474400001586 upstream_label: DDIT3 Hsap downstream: gomodel:65bc474400001544/65bc474400001545 downstream_label: GDF15 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:65c57c3400000100 title: Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65c57c3400000100/65c57c3400000162 gene_product: UniProtKB:Q9H040 gene_label: SPRTN Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:65c57c3400000100/65c57c3400000122 gene_product: UniProtKB:Q96FZ2 gene_label: HMCES Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65c57c3400000100/65c57c3400000153 gene_product: UniProtKB:Q9BX63 gene_label: BRIP1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65c57c3400000100/65c57c3400000137 gene_product: UniProtKB:Q96FZ2 gene_label: HMCES Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65c57c3400000359 title: Dosage compensation in male Drosophila by the MSL complex (composed of mle- msl-1, msl-2, msl-3 and mof) (D.melanogaster). n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65c57c3400000359/65c57c3400000418 gene_product: FB:FBgn0014340 gene_label: mof Dmel occurs_in: GO:0000805 occurs_in_label: X chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65c57c3400000359/65c57c3400000377 gene_product: FB:FBgn0005616 gene_label: msl-2 Dmel occurs_in: GO:0000805 occurs_in_label: X chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65c57c3400000359/65c57c3400000391 gene_product: FB:FBgn0002775 gene_label: msl-3 Dmel occurs_in: GO:0000805 occurs_in_label: X chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65c57c3400000359/65c57c3400000428 gene_product: FB:FBgn0005617 gene_label: msl-1 Dmel occurs_in: GO:0000805 occurs_in_label: X chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65c57c3400000359/65c57c3400000360 gene_product: FB:FBgn0005616 gene_label: msl-2 Dmel occurs_in: GO:0000805 occurs_in_label: X chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:65c57c3400002054 title: Role of RPSA in antiviral proinflammatory cytokine production (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65c57c3400002054/65c57c3400002070 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:65d7e4ac00002121 title: Apoptosis-induced by calcium import into mitochondria at ER-mitochondria contact sites mediated by the ITPR1:HSPA9:VDAC1 complex (Human) n_activities: 4 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65d7e4ac00002121/65d7e4ac00002122 gene_product: UniProtKB:P38646 gene_label: HSPA9 Hsap occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:65d7e4ac00002121/65d7e4ac00002129 gene_product: UniProtKB:Q14643 gene_label: ITPR1 Hsap occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:65d7e4ac00002121/65d7e4ac00002156 gene_product: UniProtKB:P21796 gene_label: VDAC1 Hsap occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:65f3ae5c00001357 title: Ufmylation of TP53/p53 counteracts ubiquitination and degradation of TP53/p53 by MDM2 (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65f3ae5c00001357/65f3ae5c00001358 gene_product: UniProtKB:P04637 gene_label: TP53 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:65f3ae5c00001692 title: STK38 recognizes ufmylated histone H4 in response to DNA damage, leading to ATM activation (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:65f3ae5c00001692/65f3ae5c00001693 gene_product: UniProtKB:O94874 gene_label: UFL1 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:65f3ae5c00001692/65f3ae5c00001710 gene_product: UniProtKB:Q15208 gene_label: STK38 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:6606056e00000234 title: CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6606056e00000234/6606056e00000250 upstream_label: NFATC1 Hsap downstream: gomodel:6606056e00000234/6606056e00000262 downstream_label: PDCD1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:6606056e00000234/6606056e00000235 upstream_label: CD69 Hsap downstream: gomodel:6606056e00000234/6606056e00000250 downstream_label: NFATC1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6606056e00000282 title: LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human) n_activities: 4 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:6606056e00000282/6606056e00000290 upstream_label: JAK3 Hsap downstream: gomodel:6606056e00000282/6606056e00000301 downstream_label: STAT5A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:6606056e00000485 title: UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). n_activities: 6 n_causal_edges: 8 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6606056e00000485/6606056e00000537 gene_product: UniProtKB:Q9Y6Q9 gene_label: NCOA3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000485/6606056e00000554 gene_product: UniProtKB:O95071 gene_label: UBR5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000485/6606056e00000563 gene_product: UniProtKB:O95071 gene_label: UBR5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000485/6606056e00000505 gene_product: UniProtKB:P10276 gene_label: RARA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000485/6606056e00000525 gene_product: UniProtKB:P19793 gene_label: RXRA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000485/6606056e00000497 gene_product: UniProtKB:Q9Y6Q9 gene_label: NCOA3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6606056e00000576 title: UBR5 ubiquitinates ligand-bound VDR when VDR is not associated with Nuclear receptor coactivators (NCOAs) (Human). n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6606056e00000576/6606056e00000605 gene_product: UniProtKB:O95071 gene_label: UBR5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000576/6606056e00000586 gene_product: UniProtKB:P11473 gene_label: VDR Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000576/6606056e00000582 gene_product: UniProtKB:Q9Y6Q9 gene_label: NCOA3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6606056e00000637 title: UBR5 ubiquitinates ligand-bound PGR when PGR is not associated with Nuclear receptor coactivators (NCOAs) (Human). n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6606056e00000637/6606056e00000642 gene_product: UniProtKB:P06401 gene_label: PGR Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000637/6606056e00000648 gene_product: UniProtKB:O95071 gene_label: UBR5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000637/6606056e00000638 gene_product: UniProtKB:Q15788 gene_label: NCOA1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6606056e00000678 title: 'UBR5 ubiquitinates ligand-bound ESR1 when ESR1 is not associated with Nuclear receptor coactivators (NCOAs) (Human). ' n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6606056e00000678/6606056e00000689 gene_product: UniProtKB:O95071 gene_label: UBR5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000678/6606056e00000694 gene_product: UniProtKB:P03372 gene_label: ESR1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00000678/6606056e00000679 gene_product: UniProtKB:Q15788 gene_label: NCOA1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6606056e00000903 title: Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) n_activities: 7 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 2 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6606056e00000903/6606056e00000920 upstream_label: OMA1 Hsap downstream: gomodel:6606056e00000903/6606056e00000904 downstream_label: DELE1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_OUTER_MEMBRANE - upstream: gomodel:6606056e00000903/6606056e00000920 upstream_label: OMA1 Hsap downstream: gomodel:6606056e00000903/6606056e00000904 downstream_label: DELE1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_OUTER_MEMBRANE - model: gomodel:6606056e00001308 title: Retinoic acid binds and activates RARA and RXRA nuclear receptors (Human). n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6606056e00001308/6606056e00001310 gene_product: UniProtKB:Q9Y6Q9 gene_label: NCOA3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00001308/6606056e00001317 gene_product: UniProtKB:P10276 gene_label: RARA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00001308/6606056e00001325 gene_product: UniProtKB:P19793 gene_label: RXRA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6606056e00001308/6606056e00001332 gene_product: UniProtKB:Q9Y6Q9 gene_label: NCOA3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6606056e00001890 title: Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1/HRI by DELE1 (Human). n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 2 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6606056e00001890/6606056e00001907 upstream_label: OMA1 Hsap downstream: gomodel:6606056e00001890/6606056e00001891 downstream_label: DELE1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_OUTER_MEMBRANE - upstream: gomodel:6606056e00001890/6606056e00001907 upstream_label: OMA1 Hsap downstream: gomodel:6606056e00001890/6606056e00001891 downstream_label: DELE1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - MITOCHONDRIAL_INTERMEMBRANE_SPACE downstream_compartments: - CYTOSOL status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_OUTER_MEMBRANE - model: gomodel:6606056e00002524 title: HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6606056e00002524/6606056e00002525 gene_product: UniProtKB:P69723-PRO_0000042759 gene_label: vif-Vif NCBITaxon:11706 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:66187e4700001573 title: RNA capping (GO:0036260) n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66187e4700001573/69d8496c00002843 gene_product: PomBase:SPBC19F8.07 gene_label: mcs6 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001573/69d8496c00002829 gene_product: PR:000044737 gene_label: rpb1/PhosCTD-S5 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:66187e4700001597 title: The growth hormone receptor signaling pathway (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66187e4700001597/66187e4700001621 upstream_label: JAK2 Hsap downstream: gomodel:66187e4700001597/66187e4700001630 downstream_label: STAT5B Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:66187e4700001644 title: Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). n_activities: 7 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66187e4700001644/66187e4700001661 upstream_label: JAK2 Hsap downstream: gomodel:66187e4700001644/66187e4700001670 downstream_label: STAT5B Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:66187e4700001744 title: meiotic cohesion protection in anaphase I (GO:1990813) n_activities: 13 n_causal_edges: 19 n_unresolved_locations: 13 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66187e4700001744/66187e4700001758 gene_product: PomBase:SPAC15E1.07c gene_label: moa1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001933 gene_product: PR:000027566 gene_label: hta1/PhosS121 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001744/663d668500001667 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0000779 occurs_in_label: condensed chromosome, centromeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001974 gene_product: PomBase:SPBC16H5.07c gene_label: ppa2 Spom occurs_in: GO:0000775 occurs_in_label: chromosome, centromeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001845 gene_product: PomBase:SPCC1322.12c gene_label: bub1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001938 gene_product: PR:000027557 gene_label: hta2/PhosS121 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001744/66187e4700001997 gene_product: PR:000050512 gene_label: rec8/PhosS450UnPhosS412 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001744/66187e4700001951 gene_product: PomBase:SPBP35G2.03c gene_label: sgo1 Spom occurs_in: GO:0000779 occurs_in_label: condensed chromosome, centromeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001765 gene_product: PomBase:SPAC23C11.16 gene_label: plo1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/69d8496c00003008 gene_product: PomBase:SPCC188.02 gene_label: par1 Spom occurs_in: GO:0000775 occurs_in_label: chromosome, centromeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001836 gene_product: PomBase:SPBC106.01 gene_label: mph1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/69d8496c00003031 gene_product: PomBase:SPAP8A3.09c gene_label: paa1 Spom occurs_in: GO:0000775 occurs_in_label: chromosome, centromeric region status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:66187e4700001744/66187e4700001773 gene_product: PR:000059631 gene_label: Spc7/Phos-MELT Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:66187e4700001781 title: 'silent mating-type cassette heterochromatin formation (GO:0030466) ' n_activities: 24 n_causal_edges: 27 n_unresolved_locations: 22 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66187e4700001781/662af8fa00001471 gene_product: PomBase:SPBP8B7.28c gene_label: stc1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/662af8fa00000979 gene_product: PomBase:SPAC18G6.02c gene_label: chp1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/67f85f2b00004611 gene_product: GO:0035101 gene_label: FACT complex occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/67f85f2b00004626 gene_product: PomBase:SPCC663.12 gene_label: cid12 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/67f85f2b00004585 gene_product: GO:0043494 gene_label: CLRC complex occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/665912ed00000616 gene_product: PomBase:SPAC6F12.09 gene_label: rdp1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/665912ed00001919 gene_product: PomBase:SPBC582.04c gene_label: dsh1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/67f85f2b00004537 gene_product: GO:1990243 gene_label: atf1-pcr1 complex occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/663d668500002511 gene_product: PomBase:SPCC736.11 gene_label: ago1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/66187e4700001825 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/67f85f2b00004658 gene_product: GO:0070824 gene_label: SHREC complex occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/665912ed00000973 gene_product: PomBase:SPAC23E2.02 gene_label: lsd2 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/665912ed00000630 gene_product: PomBase:SPCC1739.03 gene_label: hrr1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/66187e4700002266 gene_product: PomBase:SPBC16D10.07c gene_label: sir2 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/662af8fa00001480 gene_product: PomBase:SPAC18G6.02c gene_label: chp1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/66187e4700001860 gene_product: PomBase:SPBC16C6.10 gene_label: chp2 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/662af8fa00001530 gene_product: PomBase:SPAC24B11.06c gene_label: sty1 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/662af8fa00001494 gene_product: PomBase:SPBC83.03c gene_label: tas3 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/662af8fa00001416 gene_product: PomBase:SPCC188.13c gene_label: dcr1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/662af8fa00001319 gene_product: PomBase:SPBC800.03 gene_label: clr3 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/665912ed00000963 gene_product: PomBase:SPBC146.09c gene_label: lsd1 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66187e4700001781/665912ed00001896 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0031934 occurs_in_label: mating-type region heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:66187e4700002082 title: The erythropoietin-mediated signaling pathway (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66187e4700002082/66187e4700002092 upstream_label: JAK2 Hsap downstream: gomodel:66187e4700002082/66187e4700002097 downstream_label: STAT5B Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:66187e4700002129 title: Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). n_activities: 7 n_causal_edges: 8 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66187e4700002129/66187e4700002130 upstream_label: JAK2 Hsap downstream: gomodel:66187e4700002129/66187e4700002135 downstream_label: STAT5B Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:66187e4700002284 title: 'septation initiation signaling (GO:0031028) ' n_activities: 29 n_causal_edges: 42 n_unresolved_locations: 27 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66187e4700002284/67369e7600000071 gene_product: PomBase:SPAC4H3.11c gene_label: ppc89 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/67c10cc400002363 gene_product: GO:0090443 gene_label: FAR/SIN/STRIPAK complex occurs_in: GO:0071957 occurs_in_label: old mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002394 gene_product: PomBase:SPAC24B11.11c gene_label: sid2 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/67c10cc400007974 gene_product: PR:000027629 gene_label: clp1/PhosS396S408S467S468S493S513 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002313 gene_product: PomBase:SPAC23C11.16 gene_label: plo1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/662af8fa00001669 gene_product: PomBase:SPBC21.06c gene_label: cdc7 Spom occurs_in: GO:0071957 occurs_in_label: old mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002292 gene_product: PR:000086274 gene_label: sid4/UnPhos Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/6994852c00003107 gene_product: PomBase:SPAC23C4.12 gene_label: hhp2 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/663d668500000291 gene_product: PomBase:SPAC1782.05 gene_label: ypa2 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002301 gene_product: PomBase:SPCC1739.11c gene_label: cdc11 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/6994852c00006545 gene_product: PR:000044611 gene_label: sid4/PhosT275S278 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/6994852c00003091 gene_product: PomBase:SPBC3H7.15 gene_label: hhp1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/67c10cc400007784 gene_product: PomBase:SPAC24B11.11c gene_label: sid2 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:66187e4700002284/662af8fa00001682 gene_product: PomBase:SPAC19E9.02 gene_label: fin1 Spom occurs_in: GO:0071957 occurs_in_label: old mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/67c10cc400007832 gene_product: PomBase:SPBC428.13c gene_label: mob1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:66187e4700002284/66187e4700002349 gene_product: PR:000050507 gene_label: spg1/GTP Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/67c10cc400007695 gene_product: GO:1990334 gene_label: SIN/MEN two-component GAP complex occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002340 gene_product: PomBase:SPBC11B10.09 gene_label: cdc2 Spom occurs_in: GO:0071958 occurs_in_label: new mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002411 gene_product: PomBase:SPBC428.13c gene_label: mob1 Spom occurs_in: GO:0071958 occurs_in_label: new mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002361 gene_product: PomBase:SPBC21.06c gene_label: cdc7 Spom occurs_in: GO:0071958 occurs_in_label: new mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002375 gene_product: PomBase:SPBC24C6.07 gene_label: cdc14 Spom occurs_in: GO:0071958 occurs_in_label: new mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/662af8fa00001573 gene_product: PomBase:SPAC1006.08 gene_label: etd1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002331 gene_product: PomBase:SPAC222.10c gene_label: byr4 Spom occurs_in: GO:0071957 occurs_in_label: old mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/66187e4700002285 gene_product: PomBase:SPAC17G8.10c gene_label: dma1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/67c10cc400007710 gene_product: PR:000050507 gene_label: spg1/GTP Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:66187e4700002284/663d668500000545 gene_product: PomBase:SPBC25D12.02c gene_label: dnt1 Spom occurs_in: GO:0072686 occurs_in_label: mitotic spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:66187e4700002284/66187e4700002384 gene_product: PomBase:SPAC9G1.09 gene_label: sid1 Spom occurs_in: GO:0071958 occurs_in_label: new mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. edges: [] - model: gomodel:662af8fa00000863 title: 'Negative regulation of PIEZO2 channel activity by TMC7 (Human) ' n_activities: 2 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:662af8fa00000863/662af8fa00000875 gene_product: UniProtKB:Q7Z402 gene_label: TMC7 Hsap occurs_in: GO:0043025 occurs_in_label: neuronal cell body status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:662af8fa00002877 title: TRAIL/TRAILR1 interaction leading to apoptosis n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 1 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:662af8fa00002877/663d668500001424 upstream_label: ZDHHC3 Hsap downstream: gomodel:662af8fa00002877/663d668500001440 downstream_label: TNFRSF10A Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - PLASMA_MEMBRANE status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - CYTOSOL - model: gomodel:663d668500000226 title: VIF-mediated inhibition of STING by PTPN6 (Human-HIV) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:663d668500000226/663d668500000266 gene_product: UniProtKB:P69723 gene_label: vif NCBITaxon:11706 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:663d668500002302 title: canonical glycolysis (GO:0061621) n_activities: 20 n_causal_edges: 1 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:663d668500002302/663d668500002644 upstream_label: pyk1 Spom downstream: gomodel:663d668500002302/6a18a9ba00002185 downstream_label: pda1 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 4 kind: INPUT - model: gomodel:663d668500002824 title: Activin E signaling pathway leading to inhibition of adipose tissue development (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:663d668500002824/67b1629100002692 upstream_label: ACVR1C Hsap downstream: gomodel:663d668500002824/678073a900001657 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: r_smad_phosphorylation downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:663d668500002824/67b1629100002692 upstream_label: ACVR1C Hsap downstream: gomodel:663d668500002824/678073a900001664 downstream_label: SMAD3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: r_smad_phosphorylation downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:663d668500002824/67b1629100002692 upstream_label: ACVR1C Hsap downstream: gomodel:663d668500002824/678073a900001657 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: r_smad_phosphorylation downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:663d668500003144 title: TGFB1-mediated signaling pathway (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:663d668500003144/663d668500003152 upstream_label: TGFBR1 Hsap downstream: gomodel:663d668500003144/663d668500003164 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: tgfb_smad_signaling upstream_element: tgfb_receptor_ligation downstream_element: smad_transcriptional_output path: - tgfb_receptor_ligation - r_smad_activation - smad23_nuclear_import - smad_transcriptional_output bridges: - smad23_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:663d668500003182 title: TGFB2-mediated signaling pathway (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:663d668500003182/663d668500003190 upstream_label: TGFBR1 Hsap downstream: gomodel:663d668500003182/663d668500003202 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: tgfb_smad_signaling upstream_element: tgfb_receptor_ligation downstream_element: smad_transcriptional_output path: - tgfb_receptor_ligation - r_smad_activation - smad23_nuclear_import - smad_transcriptional_output bridges: - smad23_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:663d668500003232 title: TGFB3-mediated signaling pathway (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:663d668500003232/663d668500003240 upstream_label: TGFBR1 Hsap downstream: gomodel:663d668500003232/663d668500003252 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: tgfb_smad_signaling upstream_element: tgfb_receptor_ligation downstream_element: smad_transcriptional_output path: - tgfb_receptor_ligation - r_smad_activation - smad23_nuclear_import - smad_transcriptional_output bridges: - smad23_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:665912ed00000652 title: pericentric heterochromatin formation (GO:0031508) n_activities: 24 n_causal_edges: 29 n_unresolved_locations: 22 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:665912ed00000652/67f85f2b00004476 gene_product: GO:0070824 gene_label: SHREC complex occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/67f85f2b00004057 gene_product: GO:0043494 gene_label: CLRC complex occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000882 gene_product: PomBase:SPAC6F12.09 gene_label: rdp1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000890 gene_product: PomBase:SPCC1739.03 gene_label: hrr1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000811 gene_product: PomBase:SPAC18G6.02c gene_label: chp1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00001884 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00001080 gene_product: PomBase:SPAC17A2.13c gene_label: rad25 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000982 gene_product: PomBase:SPBC146.09c gene_label: lsd1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000867 gene_product: PomBase:SPCC736.11 gene_label: ago1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000764 gene_product: PomBase:SPAC18G6.02c gene_label: chp1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/67f85f2b00004081 gene_product: GO:0035101 gene_label: FACT complex occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000900 gene_product: PomBase:SPCC663.12 gene_label: cid12 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00001075 gene_product: PomBase:SPAC4H3.06 gene_label: rss1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000803 gene_product: PomBase:SPBP8B7.28c gene_label: stc1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000798 gene_product: PomBase:SPCC188.13c gene_label: dcr1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000754 gene_product: PomBase:SPBC16D10.07c gene_label: sir2 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000989 gene_product: PomBase:SPAC23E2.02 gene_label: lsd2 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00001878 gene_product: PomBase:SPCC1393.05 gene_label: ers1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000821 gene_product: PomBase:SPBC83.03c gene_label: tas3 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000654 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00000658 gene_product: PomBase:SPBC16C6.10 gene_label: chp2 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00000652/665912ed00001910 gene_product: PomBase:SPBC582.04c gene_label: dsh1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:665912ed00001983 title: subtelomeric heterochromatin formation (GO:0031509) n_activities: 15 n_causal_edges: 16 n_unresolved_locations: 13 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:665912ed00001983/665912ed00002158 gene_product: PomBase:SPCC736.11 gene_label: ago1 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002231 gene_product: PomBase:SPAC23E2.02 gene_label: lsd2 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002224 gene_product: PomBase:SPBC146.09c gene_label: lsd1 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002114 gene_product: PomBase:SPBP8B7.28c gene_label: stc1 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00001989 gene_product: PomBase:SPBC16C6.10 gene_label: chp2 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002122 gene_product: PomBase:SPAC18G6.02c gene_label: chp1 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/67f85f2b00004722 gene_product: GO:0043494 gene_label: CLRC complex occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/67f85f2b00004769 gene_product: GO:0070824 gene_label: SHREC complex occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002078 gene_product: PomBase:SPAC18G6.02c gene_label: chp1 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002068 gene_product: PomBase:SPBC16D10.07c gene_label: sir2 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00002132 gene_product: PomBase:SPBC83.03c gene_label: tas3 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/665912ed00001985 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:665912ed00001983/67f85f2b00004743 gene_product: GO:0035101 gene_label: FACT complex occurs_in: GO:0140720 occurs_in_label: subtelomeric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:666b894f00002484 title: ROR1 activation by IGFB5 leading to cell proliferation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:666b894f00002484/666b894f00002502 upstream_label: ERBB2 Hsap downstream: gomodel:666b894f00002484/666b894f00002510 downstream_label: CREB1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:667dfe8d00000012 title: TAAR1-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by beta-phenylethylamine (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:667dfe8d00000012/667dfe8d00000013 gene_product: UniProtKB:Q96RJ0 gene_label: TAAR1 Hsap occurs_in: GO:0012505 occurs_in_label: endomembrane system status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:667dfe8d00000048 title: TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by cadaverine (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:667dfe8d00000048/667dfe8d00000049 gene_product: UniProtKB:Q96RJ0 gene_label: TAAR1 Hsap occurs_in: GO:0012505 occurs_in_label: endomembrane system status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:667dfe8d00000109 title: TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by cyclohexylamine (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:667dfe8d00000109/667dfe8d00000110 gene_product: UniProtKB:Q96RJ0 gene_label: TAAR1 Hsap occurs_in: GO:0012505 occurs_in_label: endomembrane system status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:667dfe8d00000146 title: TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by trimethylamine (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:667dfe8d00000146/667dfe8d00000147 gene_product: UniProtKB:Q96RJ0 gene_label: TAAR1 Hsap occurs_in: GO:0012505 occurs_in_label: endomembrane system status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:667dfe8d00000179 title: TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by trimethylamine (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:667dfe8d00000179/667dfe8d00000180 gene_product: UniProtKB:Q96RJ0 gene_label: TAAR1 Hsap occurs_in: GO:0012505 occurs_in_label: endomembrane system status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:667dfe8d00000211 title: TAAR1-mediated signaling G-alpha-s ("stimulatory", activating adenylate cyclase) following activation by trimethylamine (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:667dfe8d00000211/667dfe8d00000212 gene_product: UniProtKB:Q96RJ0 gene_label: TAAR1 Hsap occurs_in: GO:0012505 occurs_in_label: endomembrane system status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:6690711d00000331 title: iron-sulfur cluster assembly (GO:0016226) and iron-sulfur cluster export from the mitochondrion (GO:0140466) n_activities: 28 n_causal_edges: 19 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6690711d00000331/6690711d00000461 upstream_label: atm1 Spom downstream: gomodel:6690711d00000331/6796b94c00003526 downstream_label: cytosolic [4Fe-4S] assembly scaffold complex predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT explanation: module: cytosolic_iron_sulfur_assembly upstream_element: abcb7_export downstream_element: nubp_scaffold_complex path: - mitochondrial_export - cia_scaffold bridges: - mitochondrial_export bridge_locations: - GO:0005743 bridge_compartments: - MITOCHONDRIAL_INNER_MEMBRANE spans_edge: false - model: gomodel:66a3e0bb00000525 title: PAQR3 mediates PPARA polyubiquitination by HUWE1 in hepatocytes. (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66a3e0bb00000525/66a3e0bb00000526 gene_product: UniProtKB:Q6TCH7 gene_label: PAQR3 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:66a3e0bb00000525/66a3e0bb00000539 gene_product: UniProtKB:Q7Z6Z7 gene_label: HUWE1 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:66a3e0bb00000922 title: PAQR3 mediates PPARG polyubiquitination by STUB1 in macrophages. (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66a3e0bb00000922/66a3e0bb00000930 gene_product: UniProtKB:Q9UNE7 gene_label: STUB1 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:66a3e0bb00000922/66a3e0bb00000923 gene_product: UniProtKB:Q6TCH7 gene_label: PAQR3 Hsap occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:66a3e0bb00002740 title: TMEFF1 restricts herpes simplex virus 1 (HHV-1) infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D (Human). n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66a3e0bb00002740/66a3e0bb00002741 gene_product: UniProtKB:A1Z0Q5 gene_label: gD NCBITaxon:10306 occurs_in: GO:0055036 occurs_in_label: virion membrane status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:66a3e0bb00002776 title: TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B (Human). n_activities: 3 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66a3e0bb00002776/66a3e0bb00002784 gene_product: UniProtKB:P06436 gene_label: gB NCBITaxon:10304 occurs_in: GO:0055036 occurs_in_label: virion membrane status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:66a3e0bb00002793 title: TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH10 and the viral envelope glycoprotein B (Human). n_activities: 3 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66a3e0bb00002793/66a3e0bb00002801 gene_product: UniProtKB:P06436 gene_label: gB NCBITaxon:10304 occurs_in: GO:0055036 occurs_in_label: virion membrane status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:66b5638000000321 title: BCAM-LAMA5 pair role in cell adhesion (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66b5638000000321/66b5638000000329 upstream_label: JAK2 Hsap downstream: gomodel:66b5638000000321/66b5638000000341 downstream_label: LAMA5 Hsap predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 2 kind: INPUT - model: gomodel:66b5638000000353 title: FXR1 forms mRNP networks that act as signaling scaffold for actomyosin remodeling (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66b5638000000353/66b5638000000393 gene_product: UniProtKB:P24844 gene_label: MYL9 Hsap occurs_in: GO:0001725 occurs_in_label: stress fiber status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:66b5638000001329 title: ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66b5638000001329/66b5638000001391 gene_product: UniProtKB:Q9NVI7 gene_label: ATAD3A Hsap occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:66b5638000001329/66b5638000001373 gene_product: UniProtKB:Q9NZJ5 gene_label: EIF2AK3 Hsap occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:66b5638000001589 title: Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66b5638000001589/66b5638000001597 upstream_label: ATF4 Hsap downstream: gomodel:66b5638000001589/66b5638000001650 downstream_label: COX7A2L Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE status: NONADJACENT distance: 4 kind: REGULATION - model: gomodel:66b5638000002701 title: IL13RA2-mediated alternative IL13 pathway leading to TGFB1 production (Human) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66b5638000002701/66b5638000002727 upstream_label: transcription factor AP-1 complex downstream: gomodel:66b5638000002701/66b5638000002744 downstream_label: TGFB1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66b5638000002701/66b5638000002702 upstream_label: IL13RA2 Hsap downstream: gomodel:66b5638000002701/66b5638000002727 downstream_label: transcription factor AP-1 complex predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:66b5638000002701/66b5638000002702 upstream_label: IL13RA2 Hsap downstream: gomodel:66b5638000002701/66b5638000002727 downstream_label: transcription factor AP-1 complex predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:66c7d41500000427 title: Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human-Zika virus) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66c7d41500000427/66c7d41500000500 gene_product: UniProtKB:Q32ZE1 gene_label: Q32ZE1 ZIKV occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:66c7d41500000754 title: Dengue virus NS5 inhibition of STAT2 signaling via UBR4 (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66c7d41500000754/66c7d41500000764 gene_product: UniProtKB:P29990 gene_label: P29990 NCBITaxon:31634 occurs_in: GO:0030430 occurs_in_label: host cell cytoplasm status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:66c7d41500002088 title: ergosterol biosynthetic process (GO:0006696), intracellular sterol transport (GO:0032366) n_activities: 26 n_causal_edges: 46 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 4 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66c7d41500002088/67f85f2b00000375 gene_product: PomBase:SPBC20F10.07 gene_label: ltc1 Spom occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:66c7d41500002088/67f85f2b00000387 gene_product: PomBase:SPBC20F10.07 gene_label: ltc1 Spom occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:66c7d41500002513 title: DDX39A inhibition of immune related RNA export to the cytoplasm (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66c7d41500002513/66c7d41500002521 upstream_label: DDX39A Hsap downstream: gomodel:66c7d41500002513/66c7d41500002531 downstream_label: MAVS Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:66c7d41500002513/66c7d41500002521 upstream_label: DDX39A Hsap downstream: gomodel:66c7d41500002513/66c7d41500002551 downstream_label: TRAF3 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:66c7d41500002687 title: "mitotic cytokinesis, division site positioning\n (GO:1902408) (G2)" n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66c7d41500002687/66c7d41500002714 gene_product: PomBase:SPCPB16A4.02c gene_label: opy1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. edges: [] - model: gomodel:66c7d41500002843 title: Protein histidyl modification to diphthamide (Mouse) n_activities: 6 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66c7d41500002843/66c7d41500003451 gene_product: MGI:MGI:1919522 gene_label: Dnajc24 Mmus occurs_in: GO:0015629 occurs_in_label: actin cytoskeleton status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:66e382fb00001097 title: BMP3 signaling leading to bone formation inhibition (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:66e382fb00001097/66e382fb00001121 upstream_label: ACVR1B Hsap downstream: gomodel:66e382fb00001097/66e382fb00001132 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001097/66e382fb00001121 upstream_label: ACVR1B Hsap downstream: gomodel:66e382fb00001097/66e382fb00001139 downstream_label: SMAD3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00001148 title: BMP3b/GDF10 signaling leading to bone formation inhibition (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:66e382fb00001148/66e382fb00001166 upstream_label: ACVR1B Hsap downstream: gomodel:66e382fb00001148/66e382fb00001184 downstream_label: SMAD3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001148/66e382fb00001166 upstream_label: ACVR1B Hsap downstream: gomodel:66e382fb00001148/66e382fb00001177 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00001232 title: BMP4 signaling pathway (Human) n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:66e382fb00001232/66e382fb00001247 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001232/66e382fb00001273 downstream_label: SMAD5 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001232/66e382fb00001247 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001232/66e382fb00001281 downstream_label: SMAD9 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001232/66e382fb00001247 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001232/66e382fb00001262 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00001388 title: BMP5 role in dendritic growth via SMAD1 (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:66e382fb00001388/66e382fb00001403 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001388/66e382fb00001396 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00001606 title: Hepcidin induction by BMP6 signaling (Human) n_activities: 8 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:66e382fb00001606/66e382fb00001719 upstream_label: SMAD5 Hsap downstream: gomodel:66e382fb00001606/66e382fb00001772 downstream_label: HAMP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66e382fb00001606/66e382fb00001713 upstream_label: SMAD1 Hsap downstream: gomodel:66e382fb00001606/66e382fb00001772 downstream_label: HAMP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66e382fb00001606/66e382fb00001724 upstream_label: SMAD9 Hsap downstream: gomodel:66e382fb00001606/66e382fb00001772 downstream_label: HAMP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66e382fb00001606/66e382fb00001707 upstream_label: ACVR1 Hsap downstream: gomodel:66e382fb00001606/66e382fb00001713 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmp_receptor_engagement downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001606/66e382fb00001707 upstream_label: ACVR1 Hsap downstream: gomodel:66e382fb00001606/66e382fb00001724 downstream_label: SMAD9 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmp_receptor_engagement downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001606/66e382fb00001707 upstream_label: ACVR1 Hsap downstream: gomodel:66e382fb00001606/66e382fb00001719 downstream_label: SMAD5 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmp_receptor_engagement downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00001786 title: Hepcidin induction by BMP2/BMP6 complex signaling (Human) n_activities: 8 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 3 locations: [] edges: - upstream: gomodel:66e382fb00001786/66e382fb00001819 upstream_label: SMAD9 Hsap downstream: gomodel:66e382fb00001786/66e382fb00001859 downstream_label: HAMP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66e382fb00001786/66e382fb00001808 upstream_label: SMAD1 Hsap downstream: gomodel:66e382fb00001786/66e382fb00001859 downstream_label: HAMP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66e382fb00001786/66e382fb00001814 upstream_label: SMAD5 Hsap downstream: gomodel:66e382fb00001786/66e382fb00001859 downstream_label: HAMP Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:66e382fb00001786/66e382fb00001885 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001786/66e382fb00001814 downstream_label: SMAD5 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001786/66e382fb00001885 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001786/66e382fb00001819 downstream_label: SMAD9 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00001786/66e382fb00001885 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00001786/66e382fb00001808 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00002105 title: BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) n_activities: 6 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 4 locations: [] edges: - upstream: gomodel:66e382fb00002105/66e382fb00002169 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00002105/66e382fb00002197 downstream_label: SMAD5 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00002105/66e382fb00002169 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00002105/66e382fb00002214 downstream_label: SMAD9 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00002105/66e382fb00002169 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00002105/66e382fb00002197 downstream_label: SMAD5 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: bmp_transcriptional_output path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00002105/66e382fb00002169 upstream_label: BMPR1A Hsap downstream: gomodel:66e382fb00002105/66e382fb00002185 downstream_label: SMAD1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: bmp_signaling upstream_element: bmpr1a_bmpr1a_type_i_receptor downstream_element: smad1_smad1_transcriptional_effector path: - bmp_receptor_engagement - smad1_5_activation - smad_complex_nuclear_import - bmp_transcriptional_output bridges: - smad_complex_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00002243 title: BMP8B role in adipocyte differentiation inhibition (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:66e382fb00002243/671ae02600000617 upstream_label: ACVR1B Hsap downstream: gomodel:66e382fb00002243/671ae02600000629 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:66e382fb00002243/671ae02600000617 upstream_label: ACVR1B Hsap downstream: gomodel:66e382fb00002243/671ae02600000636 downstream_label: SMAD3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:66e382fb00002738 title: ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66e382fb00002738/66e382fb00002905 gene_product: UniProtKB:O95835 gene_label: LATS1 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:66e382fb00002738/66e382fb00002748 gene_product: UniProtKB:Q96P20 gene_label: NLRP3 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:66e382fb00002738/66e382fb00002884 gene_product: UniProtKB:Q8TDX7 gene_label: NEK7 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:66f5faaa00000112 title: TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). n_activities: 9 n_causal_edges: 9 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66f5faaa00000112/66f5faaa00000248 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:66f5faaa00000112/66f5faaa00000240 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:66f5faaa00000441 title: Angiotensin Maturation 3 (Mouse) n_activities: 7 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66f5faaa00000441/66f5faaa00000470 gene_product: MGI:MGI:2429498 gene_label: Gprc6a Mmus occurs_in: EMAPA:32927 occurs_in_label: islets of Langerhans status: UNRESOLVED compartments: [] edges: [] - model: gomodel:66f5faaa00001170 title: RVFV NSs-FBXO3 E3 ligase mediates TFIIH complex degradation. (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:66f5faaa00001170/66f5faaa00001185 gene_product: UniProtKB:P21698 gene_label: NSS NCBITaxon:11589 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:66f5faaa00001204 title: 'Retinoid Metabolic Process 1 (Mouse) ' n_activities: 13 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:66f5faaa00001204/66f5faaa00001321 upstream_label: Pnlip Mmus downstream: gomodel:66f5faaa00001204/671ae02600000727 downstream_label: Dgat1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - EXTRACELLULAR downstream_compartments: - ER_MEMBRANE status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:67086be200000251 title: 'pyruvate decarboxylation to acetyl-CoA (GO:0006086) ' n_activities: 15 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67086be200000251/6a18a9ba00002195 upstream_label: pyk1 Spom downstream: gomodel:67086be200000251/67086be200000252 downstream_label: pda1 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 4 kind: INPUT - model: gomodel:67086be200000529 title: GPR87 role as a LPA receptor (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67086be200000529/67086be200001561 upstream_label: YAP1 Hsap downstream: gomodel:67086be200000529/67086be200001569 downstream_label: HK2 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67086be200000529/67086be200000538 upstream_label: GPR87 Hsap downstream: gomodel:67086be200000529/67086be200001561 downstream_label: YAP1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:671ae02600000030 title: Regulation of CDH5 in cell migration involved sprouting angiogenesis. (Human) n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:671ae02600000030/671ae02600000062 gene_product: UniProtKB:Q9H223 gene_label: EHD4 Hsap occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:671ae02600000030/671ae02600000040 gene_product: UniProtKB:O60716 gene_label: CTNND1 Hsap occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:671ae02600000030/671ae02600000071 gene_product: UniProtKB:Q8N3F8 gene_label: MICALL1 Hsap occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:671ae02600000030/671ae02600000052 gene_product: UniProtKB:Q9UNF0 gene_label: PACSIN2 Hsap occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:671ae02600000030/671ae02600000031 gene_product: UniProtKB:P33151 gene_label: CDH5 Hsap occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:671ae02600000676 title: GDF8 role in trophoblast invasion (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:671ae02600000676/671ae02600000695 upstream_label: SMAD2 Hsap downstream: gomodel:671ae02600000676/671ae02600000793 downstream_label: MMP2 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:671ae02600000676/671ae02600000702 upstream_label: SMAD3 Hsap downstream: gomodel:671ae02600000676/671ae02600000793 downstream_label: MMP2 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:671ae02600000676/671ae02600000718 upstream_label: TGFBR1 Hsap downstream: gomodel:671ae02600000676/671ae02600000695 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: tgfb_smad_signaling upstream_element: tgfb_receptor_ligation downstream_element: smad_transcriptional_output path: - tgfb_receptor_ligation - r_smad_activation - smad23_nuclear_import - smad_transcriptional_output bridges: - smad23_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:671ae02600000676/671ae02600000718 upstream_label: TGFBR1 Hsap downstream: gomodel:671ae02600000676/671ae02600000702 downstream_label: SMAD3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: tgfb_smad_signaling upstream_element: tgfb_receptor_ligation downstream_element: smad_transcriptional_output path: - tgfb_receptor_ligation - r_smad_activation - smad23_nuclear_import - smad_transcriptional_output bridges: - smad23_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:671ae02600002262 title: Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:671ae02600002262/671ae02600002302 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:671ae02600002262/671ae02600002310 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:671ae02600002382 title: Negative regulation of NF-kappaB signal transduction via STAT3 by CHRNA7 in macrophages (Human). n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:671ae02600002382/671ae02600002402 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:671ae02600002382/671ae02600002410 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67369e7600002505 title: mitotic spindle assembly checkpoint signalling (GO:0007094) (ON) n_activities: 19 n_causal_edges: 33 n_unresolved_locations: 12 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67369e7600002505/6a18a9ba00001546 gene_product: PomBase:SPAC821.08c gene_label: slp1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/6a18a9ba00001592 gene_product: GO:0005680 gene_label: anaphase-promoting complex occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/67369e7600002783 gene_product: PomBase:SPBC106.01 gene_label: mph1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/6a18a9ba00001622 gene_product: GO:0033597 gene_label: mitotic checkpoint complex occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/6882d2b800000723 gene_product: PomBase:SPCC1322.12c gene_label: bub1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/67369e7600002707 gene_product: PomBase:SPAC23H3.08c gene_label: bub3 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/69a0c46f00004462 gene_product: PomBase:SPCC320.13c gene_label: ark1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/67369e7600002506 gene_product: PomBase:SPBC3D6.04c gene_label: mad1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/67369e7600002722 gene_product: PomBase:SPCC338.17c gene_label: rad21 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67369e7600002505/67369e7600002581 gene_product: PomBase:SPCC1020.02 gene_label: spc7 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/67369e7600002807 gene_product: PomBase:SPBC11B10.09 gene_label: cdc2 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67369e7600002505/67369e7600002531 gene_product: PomBase:SPAC821.08c gene_label: slp1 Spom occurs_in: GO:0000776 occurs_in_label: kinetochore status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:67369e7600002892 title: Regulation of CDH5 in cell migration involved sprouting angiogenesis. (Mouse) n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67369e7600002892/67369e7600002893 gene_product: MGI:MGI:105057 gene_label: Cdh5 Mmus occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:67369e7600002892/67369e7600002898 gene_product: MGI:MGI:105100 gene_label: Ctnnd1 Mmus occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:67369e7600002892/67369e7600002904 gene_product: MGI:MGI:1345153 gene_label: Pacsin2 Mmus occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:67369e7600002892/67369e7600002914 gene_product: MGI:MGI:105870 gene_label: Micall1 Mmus occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:67369e7600002892/67369e7600002909 gene_product: MGI:MGI:1919619 gene_label: Ehd4 Mmus occurs_in: GO:0005912 occurs_in_label: adherens junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:67369e7600004124 title: Resolvin D2/GPR18-mediated activation of phagocytosis (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67369e7600004124/67369e7600004136 upstream_label: GNAS Hsap downstream: gomodel:67369e7600004124/67369e7600004145 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:67369e7600005223 title: Regulation of appetite by (CHRNA3)3:(CHRNB4)2 nAChR activated by nicotine in POMC neurons. (Human) n_activities: 2 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67369e7600005223/67369e7600005225 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:67369e7600005262 title: (CHRNA3)3:(CHRNB4)2 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67369e7600005262/67369e7600005263 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000029 title: Low agonist sensitivity (CHRNA2)3:(CHRNB2)2 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000029/675b862c00000030 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000055 title: Low agonist sensitivity (CHRNA2)3:(CHRNB2)2 nAChR activated by Acetylcholine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000055/675b862c00000056 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000081 title: High agonist sensitivity (CHRNA2)2:(CHRNB2)3 nAChR activated by Acetylcholine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000081/675b862c00000082 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000107 title: High agonist sensitivity (CHRNA2)2:(CHRNB2)3 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000107/675b862c00000108 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000133 title: High agonist sensitivity (CHRNA2)2:(CHRNB4)3 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000133/675b862c00000134 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000159 title: High agonist sensitivity (CHRNA2)2:(CHRNB4)3 nAChR activated by Acetylcholine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000159/675b862c00000160 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000185 title: Low agonist sensitivity (CHRNA2)3:(CHRNB4)2 nAChR activated by Acetylcholine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000185/675b862c00000186 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:675b862c00000211 title: Low agonist sensitivity (CHRNA2)3:(CHRNB4)2 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:675b862c00000211/675b862c00000212 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:678073a900003616 title: (CHRNA3:CHRNB4)2:CHRNB3 nAChR activated by acetylcholine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:678073a900003616/678073a900003617 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:678073a900003657 title: (CHRNA6:CHRNB4)2:CHRNB3 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:678073a900003657/678073a900003658 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:678073a900003708 title: (CHRNA6:CHRNB2)2:CHRNB3 nAChR activated by nicotine. (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:678073a900003708/678073a900003709 gene_product: GO:0005892 gene_label: acetylcholine-gated channel complex occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:6796b94c00000009 title: phosphatidylserine biosynthetic process (GO:0006659), phosphatidylethanolamine biosynthetic process (GO:0006646) and phosphatidylcholine biosynthetic process (GO:0006656) n_activities: 23 n_causal_edges: 6 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6796b94c00000009/6870555700002643 gene_product: GO:0032865 gene_label: ERMES complex occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:6796b94c00000168 title: transcription elongation by RNA polymerase II (GO:0006368) (incomplete) n_activities: 11 n_causal_edges: 14 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6796b94c00000168/67b1629100002524 gene_product: PomBase:SPBC19F8.07 gene_label: mcs6 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6796b94c00000168/67b1629100002508 gene_product: GO:0032044 gene_label: DSIF complex occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6796b94c00000168/6796b94c00000203 gene_product: PomBase:SPBC32H8.10 gene_label: cdk9 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6796b94c00000657 title: 'iron-sulfur cluster assembly (Dmel) ' n_activities: 26 n_causal_edges: 23 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6796b94c00000657/6796b94c00002766 upstream_label: ABCB7 Dmel downstream: gomodel:6796b94c00000657/6796b94c00004196 downstream_label: cytosolic [4Fe-4S] assembly scaffold complex predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - CYTOSOL status: NONADJACENT distance: 3 kind: INPUT explanation: module: cytosolic_iron_sulfur_assembly upstream_element: abcb7_export downstream_element: nubp_scaffold_complex path: - mitochondrial_export - cia_scaffold bridges: - mitochondrial_export bridge_locations: - GO:0005743 bridge_compartments: - MITOCHONDRIAL_INNER_MEMBRANE spans_edge: false - model: gomodel:6796b94c00002252 title: Transcription-pause release by the PNUTS-PP1 complex (Human). n_activities: 7 n_causal_edges: 7 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6796b94c00002252/6796b94c00002308 gene_product: UniProtKB:Q96QC0 gene_label: PPP1R10 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6796b94c00002252/67b1629100003450 gene_product: UniProtKB:P24928 gene_label: POLR2A Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:6796b94c00002938 title: Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6796b94c00002938/6796b94c00002974 gene_product: UniProtKB:Q2YD98 gene_label: UVSSA Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6796b94c00002938/6796b94c00002939 gene_product: UniProtKB:Q03468 gene_label: ERCC6 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6796b94c00002938/6796b94c00002962 gene_product: UniProtKB:P62877 gene_label: RBX1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6796b94c00002938/6796b94c00002950 gene_product: UniProtKB:Q13216 gene_label: ERCC8 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:6796b94c00004996 title: Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) n_activities: 7 n_causal_edges: 8 n_unresolved_locations: 1 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6796b94c00004996/6796b94c00004997 gene_product: UniProtKB:P0DTC2 gene_label: S protein Scov2 occurs_in: GO:0044228 occurs_in_label: host cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: - upstream: gomodel:6796b94c00004996/6796b94c00005069 upstream_label: ACAT1 Hsap downstream: gomodel:6796b94c00004996/6796b94c00005041 downstream_label: Spike protein S2 Scov2 predicate: RO:0002630 predicate_label: directly negatively regulates direct: true upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:6796b94c00004996/6796b94c00005130 upstream_label: ACE2 Hsap downstream: gomodel:6796b94c00004996/6796b94c00005041 downstream_label: Spike protein S2 Scov2 predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:6796b94c00004996/6796b94c00004999 upstream_label: TMPRSS2 Hsap downstream: gomodel:6796b94c00004996/6796b94c00005041 downstream_label: Spike protein S2 Scov2 predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6796b94c00005540 title: MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6796b94c00005540/6796b94c00005541 gene_product: UniProtKB:P04637 gene_label: TP53 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67ae98b500000055 title: iron import into cell (GO:0033212) / siderophore biosynthetic process (GO:0019290) n_activities: 15 n_causal_edges: 18 n_unresolved_locations: 0 n_nonadjacent_edges: 9 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000081 downstream_label: str1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000063 downstream_label: fio1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000063 downstream_label: fio1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000118 downstream_label: shu1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000070 downstream_label: fip1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000070 downstream_label: fip1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000063 downstream_label: fio1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000118 downstream_label: shu1 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:67ae98b500000055/67b1629100004444 upstream_label: fep1 Spom downstream: gomodel:67ae98b500000055/67ae98b500000127 downstream_label: str3 Spom predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:67b1629100001426 title: USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67b1629100001426/67b1629100001950 upstream_label: INS Hsap downstream: gomodel:67b1629100001426/67b1629100001957 downstream_label: MTOR Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:67b1629100001527 title: Lipid transport activity of OSBP (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67b1629100001527/67b1629100001531 gene_product: UniProtKB:P22059 gene_label: OSBP Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:67b1629100002705 title: Activin A signaling pathway (Human) n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:67b1629100002705/67b1629100002706 upstream_label: ACVR1B Hsap downstream: gomodel:67b1629100002705/67b1629100002762 downstream_label: SMAD3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:67b1629100002705/67b1629100002706 upstream_label: ACVR1B Hsap downstream: gomodel:67b1629100002705/67b1629100002754 downstream_label: SMAD2 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: activin_receptor_signaling upstream_element: activin_type_i_receptor downstream_element: activin_r_smad path: - r_smad_phosphorylation - activin_smad_nuclear_import - activin_transcription bridges: - activin_smad_nuclear_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:67b1629100002770 title: Protein O-linked glycosylation (O-linked fucosylation) (Dmel) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67b1629100002770/67b1629100002771 upstream_label: Ofut1 Dmel downstream: gomodel:67b1629100002770/67b1629100002780 downstream_label: fng Dmel predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - GOLGI_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - model: gomodel:67b1629100003856 title: ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). n_activities: 7 n_causal_edges: 8 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67b1629100003856/67b1629100003978 gene_product: UniProtKB:Q96C12 gene_label: ARMC5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67b1629100003856/67b1629100003857 gene_product: UniProtKB:P24928 gene_label: POLR2A Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:67b1629100004023 title: The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). n_activities: 10 n_causal_edges: 17 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67b1629100004023/67b1629100004101 gene_product: UniProtKB:P67775 gene_label: PPP2CA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67b1629100004023/67b1629100004110 gene_product: UniProtKB:P67775 gene_label: PPP2CA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67b1629100004023/67b1629100004144 gene_product: UniProtKB:Q9UL03 gene_label: INTS6 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67b1629100004023/67b1629100004119 gene_product: UniProtKB:P30153 gene_label: PPP2R1A Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67b1629100004023/67b1629100004024 gene_product: UniProtKB:P24928 gene_label: POLR2A Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:67b1629100004023/67b1629100004092 gene_product: UniProtKB:P67775 gene_label: PPP2CA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67c10cc400004816 title: The ECS(RAB40C) complex mediates ubiquitination and degradation of ANKRD28 during cell migration (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67c10cc400004816/67c10cc400004817 gene_product: UniProtKB:O15084 gene_label: ANKRD28 Hsap occurs_in: GO:0030027 occurs_in_label: lamellipodium status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:67c10cc400004918 title: The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67c10cc400004918/67c10cc400004919 gene_product: UniProtKB:Q7L0Q8 gene_label: RHOU Hsap occurs_in: GO:0005925 occurs_in_label: focal adhesion status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:67c10cc400005330 title: PARP12 activated GOLGA1 activity toward E-cadherin (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 1 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67c10cc400005330/67c10cc400005357 upstream_label: GOLGA1 Hsap downstream: gomodel:67c10cc400005330/67c10cc400005394 downstream_label: CDH1 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - PLASMA_MEMBRANE status: RELOCATING distance: 2 kind: REGULATION downstream_protein_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE - model: gomodel:67c10cc400005671 title: The classical complement pathway (Human). n_activities: 12 n_causal_edges: 13 n_unresolved_locations: 10 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67c10cc400005671/67c10cc400005672 gene_product: UniProtKB:P00736 gene_label: C1R Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400006237 gene_product: UniProtKB:P0C0L4-PRO_0000005970 gene_label: C4A-Complement_C4b-A Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400008191 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400005683 gene_product: UniProtKB:P00736-PRO_0000027579 gene_label: C1R-Complement_C1r_subcomponent_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400008180 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400005695 gene_product: GO:0062167 gene_label: complement component C1q complex occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400006155 gene_product: UniProtKB:P09871-PRO_0000027588 gene_label: C1S-Complement_C1s_subcomponent_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400006166 gene_product: UniProtKB:P09871-PRO_0000027588 gene_label: C1S-Complement_C1s_subcomponent_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400008203 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67c10cc400005671/67c10cc400006542 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67c10cc400005742 title: AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67c10cc400005742/67c10cc400005815 gene_product: UniProtKB:Q99717 gene_label: SMAD5 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67c10cc400005742/67c10cc400005807 gene_product: UniProtKB:Q15797 gene_label: SMAD1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67c10cc400006997 title: The ECS(RAB40B) complex mediates ubiquitination and degradation of LIMA1 during cell migration (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67c10cc400006997/67c10cc400006998 gene_product: UniProtKB:Q9UHB6 gene_label: LIMA1 Hsap occurs_in: GO:0030027 occurs_in_label: lamellipodium status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:67c10cc400006997/67c10cc400007002 gene_product: UniProtKB:Q12829 gene_label: RAB40B Hsap occurs_in: GO:0030027 occurs_in_label: lamellipodium status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:67e5e74400000148 title: Arabidopsis MRG domain proteins bridge two histone modifications n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400000148/67e5e74400000163 gene_product: AGI_LocusCode:AT2G44150 gene_label: ASHH3 Atal occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67e5e74400000148/67e5e74400000172 gene_product: AGI_LocusCode:AT2G45160 gene_label: SCL27 Atal occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67e5e74400000148/67e5e74400000149 gene_product: AGI_LocusCode:AT1G02740 gene_label: MRG2 Atal occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67e5e74400000148/67e5e74400000156 gene_product: AGI_LocusCode:AT1G77300 gene_label: ASHH2 Atal occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67e5e74400000671 title: The lectin complement pathway following activation by MBL2 lectin (Human). n_activities: 12 n_causal_edges: 13 n_unresolved_locations: 10 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400000671/67e5e74400000872 gene_product: UniProtKB:P48740-PRO_0000027594 gene_label: MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000889 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000733 gene_product: UniProtKB:P0C0L4-PRO_0000005970 gene_label: C4A-Complement_C4b-A Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000846 gene_product: UniProtKB:P11226 gene_label: MBL2 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000769 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000903 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000743 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000758 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000781 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000671/67e5e74400000861 gene_product: UniProtKB:P48740 gene_label: MASP1 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67e5e74400000919 title: The lectin complement pathway following activation by FCN1 lectin (Human). n_activities: 12 n_causal_edges: 13 n_unresolved_locations: 10 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400000919/67e5e74400001047 gene_product: UniProtKB:P48740-PRO_0000027594 gene_label: MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400000954 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400001036 gene_product: UniProtKB:P48740 gene_label: MASP1 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400001064 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400000943 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400001078 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400000966 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400000929 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400001025 gene_product: UniProtKB:O00602 gene_label: FCN1 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400000919/67e5e74400000920 gene_product: UniProtKB:P0C0L4-PRO_0000005970 gene_label: C4A-Complement_C4b-A Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67e5e74400001094 title: The lectin complement pathway following activation by FCN2 lectin (Human). n_activities: 12 n_causal_edges: 13 n_unresolved_locations: 10 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400001094/67e5e74400001129 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001141 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001104 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001253 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001095 gene_product: UniProtKB:P0C0L4-PRO_0000005970 gene_label: C4A-Complement_C4b-A Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001222 gene_product: UniProtKB:P48740-PRO_0000027594 gene_label: MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001239 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001211 gene_product: UniProtKB:P48740 gene_label: MASP1 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001200 gene_product: UniProtKB:Q15485 gene_label: FCN2 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001094/67e5e74400001118 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67e5e74400001269 title: The lectin complement pathway following activation by FCN3 lectin (Human). n_activities: 12 n_causal_edges: 13 n_unresolved_locations: 10 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400001269/67e5e74400001279 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001304 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001375 gene_product: UniProtKB:O75636 gene_label: FCN3 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001428 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001397 gene_product: UniProtKB:P48740-PRO_0000027594 gene_label: MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001270 gene_product: UniProtKB:P0C0L4-PRO_0000005970 gene_label: C4A-Complement_C4b-A Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001414 gene_product: UniProtKB:O00187-PRO_0000027600 gene_label: MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001386 gene_product: UniProtKB:P48740 gene_label: MASP1 Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001293 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001269/67e5e74400001316 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67e5e74400001614 title: The alternative complement pathway (Human). n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400001614/67e5e74400001701 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001614/67e5e74400001724 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001614/67e5e74400001877 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001614/67e5e74400001712 gene_product: UniProtKB:P00751-PRO_0000027547 gene_label: CFB-Bb Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001614/67e5e74400001793 gene_product: UniProtKB:P00751-PRO_0000027547 gene_label: CFB-Bb Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67e5e74400001887 title: CCL15-CCR1 association leading to inflammatory response (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:67e5e74400001887/67e5e74400002125 upstream_label: STAT3 Hsap downstream: gomodel:67e5e74400001887/67e5e74400002164 downstream_label: IL6 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:67e5e74400001888 title: The GZMK complement pathway (Human). n_activities: 9 n_causal_edges: 9 n_unresolved_locations: 7 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400001888/67e5e74400001986 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001888/67e5e74400001950 gene_product: UniProtKB:P0C0L4-PRO_0000005970 gene_label: C4A-Complement_C4b-A Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001888/67e5e74400001975 gene_product: UniProtKB:P01024-PRO_0000005911 gene_label: C3-Complement_C3b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001888/67e5e74400002063 gene_product: UniProtKB:P49863 gene_label: GZMK Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001888/67e5e74400001960 gene_product: UniProtKB:P06681-PRO_0000027612 gene_label: C2-Serine_protease_complement_C2b Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001888/67e5e74400001998 gene_product: GO:0005579 gene_label: membrane attack complex occurs_in: GO:0044218 occurs_in_label: other organism cell membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:67e5e74400001888/67e5e74400001926 gene_product: UniProtKB:P49863 gene_label: GZMK Hsap occurs_in: GO:0106139 occurs_in_label: symbiont cell surface status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:67e5e74400002819 title: CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). n_activities: 8 n_causal_edges: 8 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67e5e74400002819/67e5e74400002847 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67e5e74400002819/67e5e74400002839 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67f85f2b00000093 title: H3K4me3 regulation by H3R2 methylation (yeast) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67f85f2b00000093/67f85f2b00000129 gene_product: SGD:S000001161 gene_label: SET1 Scer occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67f85f2b00000093/67f85f2b00000101 gene_product: SGD:S000000337 gene_label: HSL7 Scer occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67f85f2b00000093/67f85f2b00000094 gene_product: SGD:S000006059 gene_label: SPP1 Scer occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:67f85f2b00000093/67f85f2b00000122 gene_product: SGD:S000001161 gene_label: SET1 Scer occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:67f85f2b00000199 title: protein insertion into ER membrane (GO:0045048), post-translational targeting to endoplasmic reticulum membrane (GO:0006620) PLUS import into Lumen (No term) and target proteins n_activities: 15 n_causal_edges: 16 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67f85f2b00000199/67f85f2b00000200 gene_product: GO:0072546 gene_label: EMC complex occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:67f85f2b00002096 title: "\t\nmitotic actomyosin contractile ring assembly (GO:1903475)" n_activities: 27 n_causal_edges: 69 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:67f85f2b00002096/680ad14200000809 gene_product: PomBase:SPBC4F6.06 gene_label: kin1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. edges: [] - model: gomodel:680ad14200000983 title: TNRC18 mediates silencing of endogenous retroviruses (ERV) by binding to H3K9me3 and mediating recruitment of Sin3-type complexes (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200000983/680ad14200001022 gene_product: GO:0070822 gene_label: Sin3-type complex occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:680ad14200000983/680ad14200001003 gene_product: UniProtKB:Q15047 gene_label: SETDB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:680ad14200000983/680ad14200000984 gene_product: UniProtKB:O15417 gene_label: TNRC18 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:680ad14200002972 title: GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). n_activities: 5 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:680ad14200002972/680ad14200002975 upstream_label: GNAI1 Hsap downstream: gomodel:680ad14200002972/680ad14200002974 downstream_label: ADCY10 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:680ad14200003421 title: Inhibition of ADARB1-mediated RNA editing by ADARB2/ADAR3 (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:680ad14200003421/680ad14200003439 upstream_label: ADARB1 Hsap downstream: gomodel:680ad14200003421/680ad14200004434 downstream_label: GRIA2 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:680ad14200003422 title: Translesion synthesis (TLS) involving REV1-MAD2L2 (HUMAN) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200003422/680ad14200003522 gene_product: UniProtKB:Q9UI95 gene_label: MAD2L2 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200003422/680ad14200003577 gene_product: UniProtKB:O60673 gene_label: REV3L Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200003422/680ad14200003447 gene_product: UniProtKB:Q9UBZ9 gene_label: REV1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:680ad14200003909 title: C20-ceramide transport activity of CERT1 (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200003909/680ad14200004337 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200004532 title: C16-ceramide transport activity of CERT1 (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200004532/680ad14200004534 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200004594 title: C18-ceramide transport activity of CERT1 (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200004594/680ad14200004596 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200004624 title: C14-ceramide transport activity of CERT1 (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200004624/680ad14200004626 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200004675 title: Phosphatidylinositol and phosphatidic acid transport by PITPNC1 (response to PLD) (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200004675/680ad14200004677 gene_product: UniProtKB:Q9UKF7 gene_label: PITPNC1 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200005268 title: 'Lipid transport activity of OSBP: 25-hydroxycholesterol (Human)' n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200005268/680ad14200005272 gene_product: UniProtKB:P22059 gene_label: OSBP Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200005355 title: PS/PtdIns4P exchange by OSBPL9/OSBPL11 in the ER-trans Gogi membrane contact site (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200005355/680ad14200005356 gene_product: GO:7770015 gene_label: intermembrane lipid transporter complex occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200005392 title: PS/PtdIns4P exchange by OSBPL9/OSBPL10 in ER-endosome membrane contact site (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200005392/680ad14200005397 gene_product: GO:7770015 gene_label: intermembrane lipid transporter complex occurs_in: GO:0140284 occurs_in_label: endoplasmic reticulum-endosome membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:680ad14200006156 title: RAD51 and RAD54B cooperate in double-strand break repair via homologous recombination (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200006156/680ad14200006159 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200006156/680ad14200007271 gene_product: UniProtKB:Q9Y620 gene_label: RAD54B Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200006156/680ad14200006162 gene_product: UniProtKB:Q9Y620 gene_label: RAD54B Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:680ad14200007322 title: BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) n_activities: 6 n_causal_edges: 6 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:680ad14200007322/680ad14200007323 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200007322/680ad14200007345 gene_product: UniProtKB:Q9H8M2 gene_label: BRD9 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200007322/680ad14200007331 gene_product: UniProtKB:Q92698 gene_label: RAD54L Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:680ad14200007322/680ad14200007357 gene_product: UniProtKB:Q92698 gene_label: RAD54L Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:682fbcd000000000 title: Histone H1 deamidation by CTSP1 promotes subsequent acetylation by EP300 and facilitates chromatin relaxation for DNA repair (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000000000/682fbcd000000001 gene_product: UniProtKB:P17812 gene_label: CTPS1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000000000/682fbcd000000012 gene_product: UniProtKB:Q09472 gene_label: EP300 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000000000/682fbcd000000023 gene_product: UniProtKB:P10412 gene_label: H1-4 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:682fbcd000002172 title: PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000002172/682fbcd000002202 gene_product: UniProtKB:Q9Y294 gene_label: ASF1A Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000002172/682fbcd000002214 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:682fbcd000002630 title: ' Syt1vesicle organization (rat)' n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000002630/682fbcd000004310 gene_product: RGD:71098 gene_label: Csnk1a1 Rnor occurs_in: GO:0045202 occurs_in_label: synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:682fbcd000003101 title: PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000003101/682fbcd000003130 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000003101/682fbcd000003142 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000003101/682fbcd000003153 gene_product: GO:0016592 gene_label: mediator complex occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000003101/682fbcd000003102 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000003101/682fbcd000003123 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:682fbcd000003765 title: 'Regulation of focal adhesion assembly: OSBPL3 transports PI4P and PC between PM and ER (Human)' n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000003765/6918f23700004420 gene_product: UniProtKB:Q6DN90 gene_label: IQSEC1 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:682fbcd000003765/69ea894900004394 gene_product: UniProtKB:Q9H4L5 gene_label: OSBPL3 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:682fbcd000003781 title: OSBPL1A sensor for cholesterol transport between late endosome/lysosome and ER (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000003781/682fbcd000003784 gene_product: UniProtKB:Q9BXW6 gene_label: OSBPL1A Hsap occurs_in: GO:0140284 occurs_in_label: endoplasmic reticulum-endosome membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:682fbcd000004101 title: CBX4 promotes PRDM16 stability by preventing its ubiquitination and degradation (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000004101/682fbcd000004142 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004101/682fbcd000004102 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:682fbcd000004233 title: PS 32:0/PtdIns4P exchange by OSBPL5/OSBPL8 in the ER-PM membrane contact site (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000004233/682fbcd000004265 gene_product: GO:7770015 gene_label: intermembrane lipid transporter complex occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:682fbcd000004638 title: BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000004638/682fbcd000004639 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004638/682fbcd000004660 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004638/682fbcd000004688 gene_product: GO:0016592 gene_label: mediator complex occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004638/682fbcd000004667 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004638/682fbcd000004679 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:682fbcd000004750 title: TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). n_activities: 7 n_causal_edges: 7 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000004750/682fbcd000004810 gene_product: UniProtKB:Q04726 gene_label: TLE3 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004750/682fbcd000004779 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004750/682fbcd000004791 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004750/682fbcd000004800 gene_product: GO:0016592 gene_label: mediator complex occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004750/682fbcd000004751 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:682fbcd000004750/682fbcd000004772 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:682fbcd000006614 title: Syp vesicle fusion (rat) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:682fbcd000006614/682fbcd000006624 gene_product: RGD:3949 gene_label: Vamp2 Rnor occurs_in: GO:0030424 occurs_in_label: axon status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:684b6c8100000003 title: PRDM16 acts as a key chromatin adapter that mediates differentiation of beige adipocytes from white adipocytes (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100000003/684b6c8100000025 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:684b6c8100000003/684b6c8100000004 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:684b6c8100000003/684b6c8100000044 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:684b6c8100000067 title: CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100000067/684b6c8100000068 gene_product: UniProtKB:Q9HAZ2 gene_label: PRDM16 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:684b6c8100000067/684b6c8100000096 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:684b6c8100000067/684b6c8100000089 gene_product: UniProtKB:Q9H9B1 gene_label: EHMT1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:684b6c8100000137 title: 'Sumoylation of ZNF76 by PIAS1 inhibits ZNF76 ability to inhibit TATA-binding protein (TBP) (Human). ' n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100000137/684b6c8100000138 gene_product: UniProtKB:P36508 gene_label: ZNF76 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:684b6c8100000137/684b6c8100000145 gene_product: UniProtKB:P20226 gene_label: TBP Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:684b6c8100000161 title: Acetylation of ZNF76 by EP300 prevents sumoylation of ZNF76 by PIAS1 (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100000161/684b6c8100000169 gene_product: UniProtKB:P20226 gene_label: TBP Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:684b6c8100000161/684b6c8100000162 gene_product: UniProtKB:P36508 gene_label: ZNF76 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:684b6c8100001759 title: NSF/ Pick1 AMPA glutamate receptor clustering n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100001759/684b6c8100001773 gene_product: RGD:69437 gene_label: Pick1 Rnor occurs_in: GO:0060076 occurs_in_label: excitatory synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:684b6c8100003650 title: SCF(Cyclin F) controls cell cycle-dependent execution of double-strand break repair through EXO1degradation (Human) n_activities: 4 n_causal_edges: 5 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100003650/684b6c8100003658 gene_product: UniProtKB:P63208 gene_label: SKP1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:684b6c8100003650/684b6c8100003673 gene_product: UniProtKB:O43303 gene_label: CCP110 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:684b6c8100003650/684b6c8100003665 gene_product: UniProtKB:P62877 gene_label: RBX1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:684b6c8100003650/684b6c8100003651 gene_product: UniProtKB:P41002 gene_label: CCNF Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:684b6c8100003714 title: SCF(Cyclin F) controls controls genome integrity and DNA repair through RRM2 degradation (Human) n_activities: 4 n_causal_edges: 5 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100003714/684b6c8100003729 gene_product: UniProtKB:P62877 gene_label: RBX1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:684b6c8100003714/684b6c8100003715 gene_product: UniProtKB:P41002 gene_label: CCNF Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL - activity_id: gomodel:684b6c8100003714/684b6c8100003722 gene_product: UniProtKB:P63208 gene_label: SKP1 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:684b6c8100004263 title: 'PI4P transfer from PM to ER by OSBPL6 ' n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:684b6c8100004263/684b6c8100004281 gene_product: UniProtKB:Q9BZF3 gene_label: OSBPL6 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:685de18700000198 title: mitochondrial tRNA modification G34 to Q (Dmel) n_activities: 9 n_causal_edges: 8 n_unresolved_locations: 0 n_nonadjacent_edges: 8 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:685de18700000198/685de18700002153 upstream_label: Tgt Dmel downstream: gomodel:685de18700000198/685de18700000219 downstream_label: AspRS-m Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700000501 upstream_label: CG2100 Dmel downstream: gomodel:685de18700000198/685de18700000434 downstream_label: Tgt Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_MATRIX downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700000501 upstream_label: CG2100 Dmel downstream: gomodel:685de18700000198/685de18700002143 downstream_label: Tgt Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_MATRIX downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700000501 upstream_label: CG2100 Dmel downstream: gomodel:685de18700000198/685de18700002153 downstream_label: Tgt Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_MATRIX downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700000501 upstream_label: CG2100 Dmel downstream: gomodel:685de18700000198/685de18700002161 downstream_label: Tgt Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_MATRIX downstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700002161 upstream_label: Tgt Dmel downstream: gomodel:685de18700000198/685de18700000246 downstream_label: TyrRS-m Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700002143 upstream_label: Tgt Dmel downstream: gomodel:685de18700000198/685de18700000213 downstream_label: HisRS Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:685de18700000198/685de18700000434 upstream_label: Tgt Dmel downstream: gomodel:685de18700000198/685de18700000216 downstream_label: AsnRS-m Dmel predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:685de18700001168 title: HPV E6 modulates MARCHF8 activity to down-regulate TRAIL-R1 and TRAIL-R2 (Human--HPV) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700001168/685de18700001187 gene_product: UniProtKB:Q5T0T0 gene_label: MARCHF8 Hsap occurs_in: GO:0020002 occurs_in_label: host cell plasma membrane status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. - activity_id: gomodel:685de18700001168/685de18700001176 gene_product: UniProtKB:P03126 gene_label: E6 HPV16 occurs_in: GO:0042025 occurs_in_label: host cell nucleus status: UNRESOLVED compartments: [] hint: term: GO:0044217 label: other organism part note: a location in another organism (host or symbiont); the compartment model covers one cell, so edges into it cross organisms. edges: [] - model: gomodel:685de18700006327 title: ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700006327/685de18700006402 gene_product: UniProtKB:P45973 gene_label: CBX5 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:685de18700006327/685de18700006385 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:685de18700006327/685de18700006347 gene_product: UniProtKB:Q9H672 gene_label: ASB7 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:685de18700006415 title: CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700006415/685de18700006416 gene_product: UniProtKB:Q9H672 gene_label: ASB7 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:685de18700006415/685de18700006445 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:685de18700006700 title: SUV39H1 phosphorylation by CDK2 inhibits its localization to heterochromatin (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700006700/685de18700006753 gene_product: UniProtKB:P45973 gene_label: CBX5 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:685de18700006700/685de18700006730 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:685de18700006767 title: phospholipid transport (GO:0015914) (ER/mitochondrion) n_activities: 5 n_causal_edges: 1 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700006767/685de18700006845 gene_product: GO:0032865 gene_label: ERMES complex occurs_in: GO:0044233 occurs_in_label: mitochondria-associated endoplasmic reticulum membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:685de18700007432 title: Regulation of LRRK2 activity by TRIM1 (Human) n_activities: 4 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700007432/685de18700007460 gene_product: UniProtKB:Q9UJV3 gene_label: MID2 Hsap occurs_in: GO:0005874 occurs_in_label: microtubule status: UNRESOLVED compartments: [] hint: term: GO:0005874 label: microtubule usual: CYTOSOL edges: [] - model: gomodel:685de18700007549 title: Pick1/AMPA glutamate receptor clustering n_activities: 5 n_causal_edges: 6 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:685de18700007549/6870555700000367 gene_product: RGD:3395 gene_label: Prkca Rnor occurs_in: GO:0044309 occurs_in_label: neuron spine status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:685de18700007549/6870555700000283 gene_product: RGD:69437 gene_label: Pick1 Rnor occurs_in: GO:0044309 occurs_in_label: neuron spine status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:6870555700000357 title: GPI anchor biosynthetic process (Dmel) n_activities: 16 n_causal_edges: 16 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6870555700000357/6870555700000509 upstream_label: PGAP5 Dmel downstream: gomodel:6870555700000357/6870555700000517 downstream_label: PGAP3 Dmel predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - GOLGI_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - model: gomodel:6870555700000578 title: PS/PtdIns4P exchange by OSBPL9/OSBPL10 in ER-TGN membrane contact site (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6870555700000578/6870555700000583 gene_product: GO:7770015 gene_label: intermembrane lipid transporter complex occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:6870555700001150 title: Perlecan interaction with post-translationally modified dystroglycan is required for acetylcholinesterase localization and accumulation at the neuromuscular junction(Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6870555700001150/689e7a5d00000955 gene_product: UniProtKB:P22303 gene_label: ACHE Hsap occurs_in: GO:0031594 occurs_in_label: neuromuscular junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:6870555700001150/689e7a5d00000940 gene_product: UniProtKB:Q9Y215 gene_label: COLQ Hsap occurs_in: GO:0031594 occurs_in_label: neuromuscular junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:6870555700001150/689e7a5d00001156 gene_product: UniProtKB:P98160 gene_label: HSPG2 Hsap occurs_in: GO:0031594 occurs_in_label: neuromuscular junction status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:6870555700001190 title: Alpha-dystroglycan is a laminin receptor involved in PI3K/AKT signaling activation in muscle (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 1 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6870555700001190/6882d2b800000972 upstream_label: LARGE1 Hsap downstream: gomodel:6870555700001190/6870555700002192 downstream_label: DAG1-Alpha-DG Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - EXTRACELLULAR status: RELOCATING distance: 3 kind: REGULATION downstream_protein_compartments: - CYTOSOL - GOLGI_LUMEN - GOLGI_MEMBRANE - model: gomodel:6870555700002061 title: Grip1 AMPA glutamate receptor clustering (rat) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6870555700002061/6870555700002120 gene_product: RGD:69331 gene_label: Git1 Rnor occurs_in: GO:0014069 occurs_in_label: postsynaptic density status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:6870555700002306 title: Transcription factor CRAMP1 specifically mediates expression of histone H1 genes, enabling Polycomb repression (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6870555700002306/6870555700002355 gene_product: UniProtKB:Q15910 gene_label: EZH2 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6870555700002306/6870555700002329 gene_product: UniProtKB:P10412 gene_label: H1-4 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6870555700002365 title: Linker histone H1.2 recognizes and binds H3K27me3 (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6870555700002365/6870555700002366 gene_product: UniProtKB:P16403 gene_label: H1-2 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6870555700002365/6870555700002388 gene_product: UniProtKB:Q15910 gene_label: EZH2 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6870555700002365/6870555700002399 gene_product: UniProtKB:P16403 gene_label: H1-2 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6870555700004670 title: FBXO24 regulation of autophagy via ULK1 degradation (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6870555700004670/6870555700004671 gene_product: UniProtKB:Q13501 gene_label: SQSTM1 Hsap occurs_in: GO:0043232 occurs_in_label: intracellular membraneless organelle status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:6882d2b800000042 title: UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). n_activities: 9 n_causal_edges: 8 n_unresolved_locations: 9 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6882d2b800000042/6882d2b800000073 gene_product: UniProtKB:Q14527 gene_label: HLTF Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000042/6882d2b800000043 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000042/6882d2b800000086 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000042/6882d2b800000057 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000042/6882d2b800000102 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000042/6882d2b800000066 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000042/6882d2b800000094 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000042/6882d2b800000050 gene_product: UniProtKB:Q14527 gene_label: HLTF Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000042/6882d2b800000110 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6882d2b800000403 title: Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6882d2b800000403/6882d2b800000427 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000403/6882d2b800000459 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000403/6882d2b800000418 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000403/6882d2b800000445 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000403/6882d2b800000467 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6882d2b800000491 title: USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). n_activities: 6 n_causal_edges: 5 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6882d2b800000491/6882d2b800000523 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000491/6882d2b800000508 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000491/6882d2b800000492 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000491/6882d2b800000515 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6882d2b800000559 title: Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6882d2b800000559/6882d2b800000560 gene_product: UniProtKB:Q96T88 gene_label: UHRF1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:6882d2b800000559/6882d2b800000569 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000559/6882d2b800000584 gene_product: UniProtKB:P26358 gene_label: DNMT1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:6882d2b800000559/6882d2b800000576 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6882d2b800001534 title: Pick1/AMPA glutamate receptor clustering2 n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6882d2b800001534/6882d2b800001592 gene_product: RGD:3395 gene_label: Prkca Rnor occurs_in: GO:0044309 occurs_in_label: neuron spine status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:689e7a5d00000098 title: Alpha-dystroglycan is a receptor for agrin required for upregulation of SOX9, a transcription factor involved in chondrocyte differentiation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:689e7a5d00000098/689e7a5d00000131 upstream_label: SOX9 Hsap downstream: gomodel:689e7a5d00000098/689e7a5d00000701 downstream_label: COL2A1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:689e7a5d00000098/689e7a5d00000108 upstream_label: DAG1-Alpha-DG Hsap downstream: gomodel:689e7a5d00000098/689e7a5d00000131 downstream_label: SOX9 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:689e7a5d00000901 title: Post-translational modification-dependent alpha-dystroglycan interaction with pikachurin (EGFLAM) is required for ribbon synapse formation (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:689e7a5d00000901/689e7a5d00001590 gene_product: UniProtKB:Q63HQ2 gene_label: EGFLAM Hsap occurs_in: GO:0098684 occurs_in_label: photoreceptor ribbon synapse status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:689e7a5d00000901/689e7a5d00002940 gene_product: UniProtKB:Q6PRD1 gene_label: GPR179 Hsap occurs_in: GO:0044292 occurs_in_label: dendrite terminus status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:689e7a5d00003515 title: Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:689e7a5d00003515/689e7a5d00003800 gene_product: UniProtKB:Q05397 gene_label: PTK2 Hsap occurs_in: GO:0005925 occurs_in_label: focal adhesion status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:689e7a5d00003515/689e7a5d00003868 gene_product: UniProtKB:P05556 gene_label: ITGB1 Hsap occurs_in: GO:0005925 occurs_in_label: focal adhesion status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:689e7a5d00003515/689e7a5d00003784 gene_product: UniProtKB:Q06124 gene_label: PTPN11 Hsap occurs_in: GO:0005925 occurs_in_label: focal adhesion status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:689e7a5d00003515/689e7a5d00003519 gene_product: UniProtKB:P20827 gene_label: EFNA1 Hsap occurs_in: GO:0005925 occurs_in_label: focal adhesion status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. - activity_id: gomodel:689e7a5d00003515/689e7a5d00003516 gene_product: UniProtKB:P29317 gene_label: EPHA2 Hsap occurs_in: GO:0005925 occurs_in_label: focal adhesion status: UNRESOLVED compartments: [] hint: term: GO:0030054 label: cell junction note: a junction spans plasma membrane, cytosol and extracellular region; name the side the activity is on. edges: [] - model: gomodel:689e7a5d00004061 title: Regulation of Respiratory chain complex I by COXFA4L2 upon hypoxia. (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:689e7a5d00004061/689e7a5d00004268 upstream_label: HIF1A Hsap downstream: gomodel:689e7a5d00004061/689e7a5d00004259 downstream_label: COXFA4L2 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:689e7a5d00004320 title: Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Mouse) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:689e7a5d00004320/689e7a5d00004344 upstream_label: respiratory chain complex I downstream: gomodel:689e7a5d00004320/689e7a5d00004356 downstream_label: mXBP1/iso2 Mmus predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 4 kind: REGULATION - upstream: gomodel:689e7a5d00004320/689e7a5d00004321 upstream_label: Hif1a Mmus downstream: gomodel:689e7a5d00004320/689e7a5d00004334 downstream_label: Coxfa4l2 Mmus predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:689e7a5d00004412 title: Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:689e7a5d00004412/689e7a5d00004413 upstream_label: HIF1A Hsap downstream: gomodel:689e7a5d00004412/69d8496c00005719 downstream_label: COXFA4L2 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:689e7a5d00004412/689e7a5d00004425 upstream_label: respiratory chain complex I downstream: gomodel:689e7a5d00004412/689e7a5d00004431 downstream_label: XBP1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 4 kind: REGULATION - model: gomodel:689e7a5d00005283 title: Cholesterol transport in ER-Endosome MCS enabled by STARD3 (Human) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:689e7a5d00005283/689e7a5d00005284 gene_product: UniProtKB:Q14849 gene_label: STARD3 Hsap occurs_in: GO:0140284 occurs_in_label: endoplasmic reticulum-endosome membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68b0f0d000000047 title: The HUSH complex mediates silencing of transposable elements (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 5 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000000047/68b0f0d000000059 gene_product: UniProtKB:Q9UK61 gene_label: TASOR Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000000047/68b0f0d000000068 gene_product: UniProtKB:Q99549 gene_label: MPHOSPH8 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000000047/68b0f0d000000104 gene_product: UniProtKB:Q15047 gene_label: SETDB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000000047/68b0f0d000000093 gene_product: UniProtKB:Q9Y6X9 gene_label: MORC2 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000000047/68b0f0d000000080 gene_product: UniProtKB:Q8NEY8 gene_label: PPHLN1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:68b0f0d000000123 title: The HUSH2 complex mediates epigenetic repression of interferon-stimulated genes. (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000000123/68b0f0d000000172 gene_product: UniProtKB:P14316 gene_label: IRF2 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000000123/68b0f0d000000163 gene_product: UniProtKB:Q5VWN6 gene_label: TASOR2 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:68b0f0d000001211 title: De novo sphingomyelin biosynthesis (CerS1) n_activities: 6 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000001211/68b0f0d000001264 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68b0f0d000004152 title: CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) n_activities: 6 n_causal_edges: 7 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000004152/68b0f0d000004205 gene_product: UniProtKB:P18615 gene_label: NELFE Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000004152/68b0f0d000004240 gene_product: UniProtKB:P21127 gene_label: CDK11B Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:68b0f0d000004290 title: De novo sphingomyelin synthesis (Human) CerS5 n_activities: 6 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000004290/68b0f0d000004349 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68b0f0d000004550 title: C21-steroid hormone biosynthetic process 1 (Mouse) n_activities: 8 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68b0f0d000004550/68b0f0d000004596 upstream_label: Tspo Mmus downstream: gomodel:68b0f0d000004550/68b0f0d000004579 downstream_label: Cyp11a1 Mmus predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:68b0f0d000005568 title: De novo sphingomyelin synthesis (Human) CerS4 n_activities: 6 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000005568/68b0f0d000005627 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68b0f0d000006228 title: Mineralocorticoid biosynthetic process (Mouse) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68b0f0d000006228/68b0f0d000006267 upstream_label: Cyp21a1 Mmus downstream: gomodel:68b0f0d000006228/68b0f0d000006271 downstream_label: Cyp11b2 Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - ER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:68b0f0d000008340 title: Nuclear 'de novo' pyrimidine nucleobase biosynthetic process involving SHMT1, TYMS and DHFR (human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000008340/68b0f0d000008536 gene_product: UniProtKB:P34896 gene_label: SHMT1 Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:68b0f0d000008340/68b0f0d000008866 gene_product: UniProtKB:P00374 gene_label: DHFR Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:68b0f0d000008340/68b0f0d000008553 gene_product: UniProtKB:P04818 gene_label: TYMS Hsap occurs_in: GO:0005657 occurs_in_label: replication fork status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:68b0f0d000008519 title: C16-Ceramide-1-P transport enabled by CPTP (CERT1 transports Cer for C1P synthesis) (Human) n_activities: 3 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000008519/68b0f0d000008570 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68b0f0d000008746 title: nitrogen utilization (GO:0019740) (ammonia, proline, D-alanine, L-alanine) n_activities: 11 n_causal_edges: 10 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68b0f0d000008746/68b0f0d000008793 gene_product: PomBase:SPBC1683.13c gene_label: cha4 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000008746/68b0f0d000008781 gene_product: GO:0016591 gene_label: RNA polymerase II, holoenzyme occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000008746/68b0f0d000008773 gene_product: GO:0033698 gene_label: Rpd3L complex occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68b0f0d000008746/68b0f0d000008747 gene_product: PomBase:SPCC1020.10 gene_label: oca2 Spom occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:68d5ebd600000274 title: 'Neuroprotection involving MT-RNR2 binding to a receptor complex containing IL27RA, CNTFR and IL6ST (human)' n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68d5ebd600000274/68d5ebd600000275 upstream_label: humanin receptor complex downstream: gomodel:68d5ebd600000274/68d5ebd600000503 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:68d5ebd600002260 title: 'CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) ' n_activities: 10 n_causal_edges: 16 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:68d5ebd600002260/68d5ebd600002375 upstream_label: JAK1 Hsap downstream: gomodel:68d5ebd600002260/68d5ebd600002393 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:68d5ebd600002538 title: glycolytic process through fructose-6-phosphate (rat) n_activities: 9 n_causal_edges: 0 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68d5ebd600002538/68d5ebd600003547 gene_product: RGD:3336 gene_label: Pklr Rnor occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:68d5ebd600002538/68d5ebd600002851 gene_product: RGD:619878 gene_label: Pgk1 Rnor occurs_in: GO:0005575 occurs_in_label: cellular_component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:68d5ebd600002652 title: 'sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) ' n_activities: 6 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68d5ebd600002652/6918f23700002060 upstream_label: IL6ST Hsap downstream: gomodel:68d5ebd600002652/68d5ebd600002700 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:68d5ebd600002652/6918f23700002067 upstream_label: LIFR Hsap downstream: gomodel:68d5ebd600002652/68d5ebd600002700 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:68d5ebd600002976 title: Gamma-aminobutyric acid catabolic process (Mouse) n_activities: 3 n_causal_edges: 1 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68d5ebd600002976/68d5ebd600002990 upstream_label: Slc6a1 Mmus downstream: gomodel:68d5ebd600002976/68d5ebd600002994 downstream_label: Abat Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:68d5ebd600003246 title: 'CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) ' n_activities: 7 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68d5ebd600003246/6918f23700002048 upstream_label: LIFR Hsap downstream: gomodel:68d5ebd600003246/68d5ebd600003254 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:68d5ebd600003246/6918f23700002048 upstream_label: LIFR Hsap downstream: gomodel:68d5ebd600003246/68d5ebd600003254 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:68d5ebd600003246/6918f23700002041 upstream_label: IL6ST Hsap downstream: gomodel:68d5ebd600003246/68d5ebd600003254 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:68fac5ed00000028 title: Formation of neutrophil extracellular traps (NETs) by PADI4 and MPO via dissociation of chromatin and microbicidal activity of NETs by ELANE and MPO (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 1 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68fac5ed00000028/68fac5ed00000042 upstream_label: MPO Hsap downstream: gomodel:68fac5ed00000028/68fac5ed00000055 downstream_label: MPO Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - upstream: gomodel:68fac5ed00000028/68fac5ed00000042 upstream_label: MPO Hsap downstream: gomodel:68fac5ed00000028/68fac5ed00000074 downstream_label: ELANE Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: RELOCATING distance: 3 kind: REGULATION downstream_protein_compartments: - CYTOSOL - model: gomodel:68fac5ed00000166 title: 'CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) ' n_activities: 7 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:68fac5ed00000166/68fac5ed00000205 upstream_label: JAK2 Hsap downstream: gomodel:68fac5ed00000166/68fac5ed00000214 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:68fac5ed00000166/68fac5ed00000196 upstream_label: JAK1 Hsap downstream: gomodel:68fac5ed00000166/68fac5ed00000214 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:68fac5ed00000361 title: PI4P transfer from PM to ER by OSBPL6. (Mouse) n_activities: 1 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68fac5ed00000361/68fac5ed00000373 gene_product: MGI:MGI:2139014 gene_label: Osbpl6 Mmus occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68fac5ed00000572 title: De novo sphingomyelin synthesis via CERS5. (Human) n_activities: 6 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68fac5ed00000572/68fac5ed00000625 gene_product: UniProtKB:Q9Y5P4 gene_label: CERT1 Hsap occurs_in: GO:0160258 occurs_in_label: endoplasmic reticulum-trans-Golgi network membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68fac5ed00001851 title: G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). n_activities: 7 n_causal_edges: 8 n_unresolved_locations: 7 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68fac5ed00001851/68fac5ed00001869 gene_product: UniProtKB:P45973 gene_label: CBX5 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001851/68fac5ed00001896 gene_product: UniProtKB:P83916 gene_label: CBX1 Hsap occurs_in: GO:0000792 occurs_in_label: heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001851/68fac5ed00001944 gene_product: UniProtKB:Q9H5I1 gene_label: SUV39H2 Hsap occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001851/68fac5ed00001852 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001851/68fac5ed00001878 gene_product: UniProtKB:Q7L622 gene_label: G2E3 Hsap occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001851/68fac5ed00001935 gene_product: UniProtKB:O43463 gene_label: SUV39H1 Hsap occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001851/68fac5ed00001888 gene_product: UniProtKB:Q9H5I1 gene_label: SUV39H2 Hsap occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:68fac5ed00001906 title: Formation of H3K14ub by rbx1 component of the CLRC complex promotes formation of H3K9me3 by clr4 (S.pombe). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 3 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68fac5ed00001906/68fac5ed00001916 gene_product: PomBase:SPBC428.08c gene_label: clr4 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001906/68fac5ed00001907 gene_product: PomBase:SPAC23H4.18c gene_label: rbx1 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:68fac5ed00001906/68fac5ed00001926 gene_product: PomBase:SPAC664.01c gene_label: swi6 Spom occurs_in: GO:0005721 occurs_in_label: pericentric heterochromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:68fac5ed00002250 title: Phosphatidylinositol and phosphatidic acid transport by PITPNM1 in ER-PM MCS (response to PLC) (Human) n_activities: 2 n_causal_edges: 1 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68fac5ed00002250/693b3c0900002622 gene_product: UniProtKB:O95292 gene_label: VAPB Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:68fac5ed00002250/68fac5ed00002251 gene_product: UniProtKB:O00562 gene_label: PITPNM1 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:68fac5ed00002909 title: CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:68fac5ed00002909/6918f23700001617 upstream_label: LIFR Hsap downstream: gomodel:68fac5ed00002909/68fac5ed00002980 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:68fac5ed00002909/6918f23700001609 upstream_label: IL6ST Hsap downstream: gomodel:68fac5ed00002909/68fac5ed00002980 downstream_label: STAT3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:68fac5ed00003196 title: Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) n_activities: 6 n_causal_edges: 0 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:68fac5ed00003196/68fac5ed00003550 gene_product: UniProtKB:Q9BZ72 gene_label: PITPNM2 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:68fac5ed00003196/68fac5ed00003213 gene_product: UniProtKB:O00562 gene_label: PITPNM1 Hsap occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:69169b7400000113 title: ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). n_activities: 8 n_causal_edges: 7 n_unresolved_locations: 8 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69169b7400000113/69169b7400000150 gene_product: UniProtKB:Q96QS3 gene_label: ARX Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000198 gene_product: UniProtKB:Q96QS3 gene_label: ARX Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000174 gene_product: UniProtKB:O43316 gene_label: PAX4 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000205 gene_product: UniProtKB:Q96QS3 gene_label: ARX Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000164 gene_product: UniProtKB:O43316 gene_label: PAX4 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000191 gene_product: UniProtKB:Q96QS3 gene_label: ARX Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000184 gene_product: UniProtKB:Q96QS3 gene_label: ARX Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69169b7400000113/69169b7400000157 gene_product: UniProtKB:Q2TB10 gene_label: ZNF800 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:6918f23700003265 title: LIF signaling pathway involving IL6ST-LIFR (human) n_activities: 6 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:6918f23700003265/6918f23700003735 upstream_label: JAK2 Hsap downstream: gomodel:6918f23700003265/6918f23700003289 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:6918f23700003265/6918f23700003500 upstream_label: JAK1 Hsap downstream: gomodel:6918f23700003265/6918f23700003289 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:6918f23700003787 title: ' exocytosis (GO:0006887) for septum assembly (partial) ' n_activities: 12 n_causal_edges: 29 n_unresolved_locations: 9 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6918f23700003787/6918f23700003951 gene_product: PomBase:SPCC1281.01 gene_label: ags1 Spom occurs_in: GO:0000935 occurs_in_label: division septum status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003923 gene_product: GO:1990071 gene_label: TRAPPII protein complex occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003788 gene_product: PomBase:SPAC688.07c gene_label: rng10 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003837 gene_product: PomBase:SPBC30D10.17c gene_label: smi1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003811 gene_product: PomBase:SPCC584.05 gene_label: sec1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003867 gene_product: PomBase:SPCC1840.02c gene_label: bgs4 Spom occurs_in: GO:0000936 occurs_in_label: primary cell septum status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003808 gene_product: PomBase:SPAC11E3.02c gene_label: ync13 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003846 gene_product: PomBase:SPBC19G7.05c gene_label: bgs1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:6918f23700003787/6918f23700003944 gene_product: PomBase:SPAC1F5.05c gene_label: mso1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. edges: [] - model: gomodel:6918f23700004722 title: clathrin-dependent endocytosis (GO:0072583) n_activities: 53 n_causal_edges: 116 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:6918f23700004722/6918f23700004950 gene_product: PomBase:SPBC32H8.12c gene_label: act1 Spom occurs_in: GO:0005884 occurs_in_label: actin filament status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:693b3c0900000536 title: pheromone response MAPK cascade (GO:0071507) n_activities: 25 n_causal_edges: 58 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:693b3c0900000536/693b3c0900000558 gene_product: PomBase:SPBC1D7.05 gene_label: byr2 Spom occurs_in: GO:0051286 occurs_in_label: cell tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900000536/693b3c0900000537 gene_product: PomBase:SPAC1D4.13 gene_label: byr1 Spom occurs_in: GO:0051286 occurs_in_label: cell tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900000536/693b3c0900001275 gene_product: PomBase:SPBC646.12c gene_label: gap1 Spom occurs_in: GO:0005937 occurs_in_label: mating projection status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900000536/693b3c0900001293 gene_product: PomBase:SPAC23E2.03c gene_label: sms1 Spom occurs_in: GO:0051286 occurs_in_label: cell tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900000536/693b3c0900000581 gene_product: PomBase:SPCC1442.01 gene_label: ste6 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900000536/693b3c0900000571 gene_product: PomBase:SPAC17H9.09c gene_label: ras1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:693b3c0900001715 title: Modulation of TRIM32 activity by Seneca virus Protease 3C (Human-Seneca virus) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:693b3c0900001715/693b3c0900001725 gene_product: UniProtKB:Q155Z9-PRO_0000446928 gene_label: Q155Z9-Capsid_protein_VP3 NCBITaxon:686944 occurs_in: GO:0044423 occurs_in_label: virion component status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:693b3c0900002174 title: retrograde transport endosome to Golgi (GO:0042147) (partial) n_activities: 14 n_causal_edges: 23 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:693b3c0900002174/693b3c0900002185 upstream_label: retromer, tubulation complex downstream: gomodel:693b3c0900002174/6a2b236300000115 downstream_label: grp1 Spom predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE downstream_compartments: - GOLGI_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:693b3c0900003452 title: "\t\nascospore-type prospore membrane formation (GO:0032120) ascospore wall biogenesis (GO:0070591) (partial)" n_activities: 28 n_causal_edges: 55 n_unresolved_locations: 6 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:693b3c0900003452/693b3c0900003453 gene_product: PomBase:SPCC1183.12 gene_label: spo13 Spom occurs_in: GO:0035974 occurs_in_label: meiotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:693b3c0900003452/693b3c0900003615 gene_product: PomBase:SPAC6G9.04 gene_label: spo7 Spom occurs_in: GO:0035974 occurs_in_label: meiotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:693b3c0900003452/693b3c0900004788 gene_product: PomBase:SPBC646.06c gene_label: agn2 Spom occurs_in: GO:0072324 occurs_in_label: ascus epiplasm status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900003452/693b3c0900003541 gene_product: PomBase:SPBC16C6.14 gene_label: spo2 Spom occurs_in: GO:0035974 occurs_in_label: meiotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:693b3c0900003452/693b3c0900003531 gene_product: PomBase:SPCC1739.04c gene_label: dms1 Spom occurs_in: GO:0035974 occurs_in_label: meiotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:693b3c0900003452/693b3c0900003504 gene_product: PomBase:SPAC1F3.06c gene_label: spo15 Spom occurs_in: GO:0035974 occurs_in_label: meiotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. edges: [] - model: gomodel:693b3c0900004140 title: "mating projection formation (GO:0031382), mating projection tip cell wall disassembly (GO:1904541), cytogamy (GO:0000755)\n\ \ " n_activities: 36 n_causal_edges: 71 n_unresolved_locations: 28 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:693b3c0900004140/69c59f8a00000512 gene_product: PomBase:SPCC1919.10c gene_label: myo52 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/6994852c00002751 gene_product: GO:0031941 gene_label: filamentous actin occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004580 gene_product: PomBase:SPBC21D10.06c gene_label: map4 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004161 gene_product: PomBase:SPAC16E8.09 gene_label: scd1 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004839 gene_product: PomBase:SPBC1105.05 gene_label: exg1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004294 gene_product: PomBase:SPAC20G4.02c gene_label: fus1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004188 gene_product: PomBase:SPAC22H10.07 gene_label: scd2 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004374 gene_product: PomBase:SPCC1919.10c gene_label: myo52 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004402 gene_product: PomBase:SPAC23D3.10c gene_label: eng2 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004310 gene_product: PomBase:SPBC32H8.12c gene_label: act1 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004821 gene_product: PomBase:SPAC821.09 gene_label: eng1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004549 gene_product: PomBase:SPAC27F1.02c gene_label: cdc8 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/69c59f8a00000443 gene_product: GO:0000145 gene_label: exocyst occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004339 gene_product: PomBase:SPCC126.06 gene_label: twf1 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004806 gene_product: PomBase:SPBC646.06c gene_label: agn2 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004420 gene_product: PomBase:SPBP8B7.02 gene_label: rng9 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004151 gene_product: PomBase:SPAC17H9.09c gene_label: ras1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004603 gene_product: PomBase:SPAC4A8.15c gene_label: cdc3 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/69c59f8a00000542 gene_product: PomBase:SPAC18G6.03 gene_label: ypt3 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004394 gene_product: PomBase:SPAC14C4.09 gene_label: agn1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004570 gene_product: PomBase:SPAP11E10.02c gene_label: mam3 Spom occurs_in: GO:0043332 occurs_in_label: mating projection tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/69c59f8a00000430 gene_product: PomBase:SPAC20G4.02c gene_label: fus1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004328 gene_product: PomBase:SPAC631.01c gene_label: acp2 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004364 gene_product: PomBase:SPBC2D10.14c gene_label: myo51 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/69c59f8a00000551 gene_product: CHEBI:36080 gene_label: protein occurs_in: GO:0005937 occurs_in_label: mating projection status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:693b3c0900004140/693b3c0900004352 gene_product: PomBase:SPAC4H3.14c gene_label: rng8 Spom occurs_in: GO:0070648 occurs_in_label: formin-nucleated actin cable status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/69c59f8a00000447 gene_product: GO:0031201 gene_label: SNARE complex occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL - activity_id: gomodel:693b3c0900004140/693b3c0900004317 gene_product: PomBase:SPAC12B10.07 gene_label: acp1 Spom occurs_in: GO:1990819 occurs_in_label: mating projection actin fusion focus status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:693b3c0900004859 title: ' endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888) (partial)' n_activities: 29 n_causal_edges: 40 n_unresolved_locations: 0 n_nonadjacent_edges: 16 n_bridged_edges: 6 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:693b3c0900004859/6a0784b700000569 upstream_label: yip1 Spom downstream: gomodel:693b3c0900004859/693b3c0900004902 downstream_label: erv29 Spom predicate: RO:0002630 predicate_label: directly negatively regulates direct: true upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:693b3c0900004859/693b3c0900004919 upstream_label: emp43 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900004919 upstream_label: emp43 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900004912 upstream_label: erv14 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900004936 upstream_label: cor1 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/69d8496c00004624 upstream_label: ssp120 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/69d8496c00004624 upstream_label: ssp120 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900004902 upstream_label: erv29 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900004902 upstream_label: erv29 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/6a0784b700000094 upstream_label: rud3 Spom downstream: gomodel:693b3c0900004859/69c59f8a00000967 downstream_label: SNARE complex predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE downstream_compartments: - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:693b3c0900004859/69c59f8a00002459 upstream_label: svp26 Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/6a0784b700000345 upstream_label: sec2301 Spom downstream: gomodel:693b3c0900004859/693b3c0900004896 downstream_label: sec13 Spom predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:693b3c0900004859/6a0784b700000345 upstream_label: sec2301 Spom downstream: gomodel:693b3c0900004859/69c59f8a00002333 downstream_label: sec31 Spom predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - ER_LUMEN - ER_MEMBRANE downstream_compartments: - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:693b3c0900004859/69c59f8a00000967 upstream_label: SNARE complex downstream: gomodel:693b3c0900004859/69ea894900001717 downstream_label: sec18 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - VESICLE_MEMBRANE downstream_compartments: - GOLGI_LUMEN - GOLGI_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900005003 upstream_label: SPCC126.08c Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - upstream: gomodel:693b3c0900004859/693b3c0900005003 upstream_label: SPCC126.08c Spom downstream: gomodel:693b3c0900004859/693b3c0900004889 downstream_label: sec24 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - ER_LUMEN - ER_MEMBRANE status: NONADJACENT distance: 2 kind: INPUT - model: gomodel:693b3c0900005257 title: Regulation of the TLR signaling by SMAD6-SMURF1 (Human) n_activities: 5 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:693b3c0900005257/693b3c0900005303 upstream_label: TGFB1 Hsap downstream: gomodel:693b3c0900005257/693b3c0900005258 downstream_label: SMAD6 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CHLOROPLAST_ENVELOPE - CHLOROPLAST_STROMA - CYTOSOL - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - ER_LUMEN - ER_MEMBRANE - GOLGI_LUMEN - GOLGI_MEMBRANE - LIPID_DROPLET - LYSOSOME_LUMEN - LYSOSOME_MEMBRANE - MITOCHONDRIAL_INNER_MEMBRANE - MITOCHONDRIAL_INTERMEMBRANE_SPACE - MITOCHONDRIAL_MATRIX - MITOCHONDRIAL_OUTER_MEMBRANE - PEROXISOME_MATRIX - PEROXISOME_MEMBRANE - THYLAKOID_LUMEN - THYLAKOID_MEMBRANE - VACUOLE_LUMEN - VACUOLE_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:696022cd00000016 title: Protein maturation of SHH by autocleavage, autocholesterylation and palmitoylation by HHAT (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 1 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:696022cd00000016/696022cd00000024 upstream_label: HHAT Hsap downstream: gomodel:696022cd00000016/696022cd00000017 downstream_label: SHH-ShhN Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - ER_MEMBRANE downstream_compartments: - EXTRACELLULAR status: RELOCATING distance: 3 kind: REGULATION downstream_protein_compartments: - CYTOSOL - ER_LUMEN - ER_MEMBRANE - model: gomodel:696022cd00000124 title: SMO is translocated in primary cilium via a beta-arrestin and KIF3A-dependent mechanism (Human). n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:696022cd00000124/696022cd00000163 gene_product: UniProtKB:Q9Y496 gene_label: KIF3A Hsap occurs_in: GO:0097730 occurs_in_label: non-motile cilium status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:696022cd00001645 title: Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). n_activities: 11 n_causal_edges: 9 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:696022cd00001645/696022cd00001720 gene_product: UniProtKB:Q9NRP7 gene_label: STK36 Hsap occurs_in: GO:0097542 occurs_in_label: ciliary tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. - activity_id: gomodel:696022cd00001645/696022cd00001729 gene_product: UniProtKB:Q96C45 gene_label: ULK4 Hsap occurs_in: GO:0097542 occurs_in_label: ciliary tip status: UNRESOLVED compartments: [] hint: term: GO:0005575 label: cellular_component note: the root term carries no location. edges: [] - model: gomodel:696022cd00002138 title: OSM signaling pathway involving IL6ST-LIFR receptor complex (human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:696022cd00002138/696022cd00002169 upstream_label: JAK1 Hsap downstream: gomodel:696022cd00002138/696022cd00002148 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:696022cd00002138/696022cd00002190 upstream_label: JAK2 Hsap downstream: gomodel:696022cd00002138/696022cd00002148 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:696022cd00002481 title: OSM signaling pathway involving IL6ST-OSMR receptor complex (human) n_activities: 5 n_causal_edges: 7 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:696022cd00002481/696022cd00002521 upstream_label: JAK2 Hsap downstream: gomodel:696022cd00002481/696022cd00002489 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:696022cd00002481/696022cd00002510 upstream_label: JAK1 Hsap downstream: gomodel:696022cd00002481/696022cd00002489 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:696022cd00002619 title: IL31 signaling pathway involving IL31RA-OSMR (human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 1 locations: [] edges: - upstream: gomodel:696022cd00002619/696022cd00002634 upstream_label: JAK1 Hsap downstream: gomodel:696022cd00002619/696022cd00002627 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:69729a3800000296 title: CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 2 locations: [] edges: - upstream: gomodel:69729a3800000296/69729a3800000320 upstream_label: JAK2 Hsap downstream: gomodel:69729a3800000296/69729a3800000304 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - upstream: gomodel:69729a3800000296/69729a3800000311 upstream_label: JAK1 Hsap downstream: gomodel:69729a3800000296/69729a3800000304 downstream_label: STAT3 Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: EXPLAINED distance: 2 kind: REGULATION explanation: module: jak_stat_signaling upstream_element: jak_activation downstream_element: stat_transcriptional_activation path: - jak_activation - receptor_phosphorylation - stat_recruitment_phosphorylation - stat_dimerization_import - stat_transcription bridges: - stat_dimerization_import via_modules: - karyopherin_nuclear_protein_import bridge_locations: - GO:0005635 - GO:0005654 - GO:0005829 bridge_compartments: - CYTOSOL - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN spans_edge: true - model: gomodel:69729a3800001390 title: G2/M transition of mitotic cell cycle (GO:0000086|) (in progress) n_activities: 18 n_causal_edges: 25 n_unresolved_locations: 11 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69729a3800001390/6a18a9ba00001880 gene_product: PR:000050398 gene_label: cut12/UnPhosT75T78 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:69729a3800001390/6a2b236300000083 gene_product: PomBase:SPBC1539.08 gene_label: arf6 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:69729a3800001390/6a18a9ba00001885 gene_product: PomBase:SPBC11B10.09 gene_label: cdc2 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:69729a3800001390/6a18a9ba00001872 gene_product: PomBase:SPBC649.05 gene_label: cut12 Spom occurs_in: GO:0061497 occurs_in_label: inner plaque of mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:69729a3800001390/6a18a9ba00001855 gene_product: PomBase:SPAC23C11.16 gene_label: plo1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:69729a3800001390/69729a3800001391 gene_product: PomBase:SPBC11B10.09 gene_label: cdc2 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:69729a3800001390/69729a3800002263 gene_product: PomBase:SPAC2F7.03c gene_label: pom1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:69729a3800001390/69729a3800002374 gene_product: PomBase:SPCC297.03 gene_label: ssp1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:69729a3800001390/69729a3800002363 gene_product: PomBase:SPBC23G7.04c gene_label: nif1 Spom occurs_in: GO:0032153 occurs_in_label: cell division site status: UNRESOLVED compartments: [] hint: term: GO:0032153 label: cell division site note: a region of the cell periphery, not a compartment. - activity_id: gomodel:69729a3800001390/6a18a9ba00001931 gene_product: PomBase:SPAC1782.09c gene_label: clp1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. - activity_id: gomodel:69729a3800001390/6a18a9ba00001897 gene_product: PomBase:SPAC19E9.02 gene_label: fin1 Spom occurs_in: GO:0044732 occurs_in_label: mitotic spindle pole body status: UNRESOLVED compartments: [] hint: term: GO:0005816 label: spindle pole body usual: NUCLEAR_ENVELOPE note: the fungal spindle pole body is embedded in the nuclear envelope. edges: [] - model: gomodel:69729a3800001528 title: CD36 transport to the plasma membrane for muscle regeneration (Human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800001528/69729a3800002699 upstream_label: IGF1 Hsap downstream: gomodel:69729a3800001528/69729a3800001686 downstream_label: MAPK1 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - EXTRACELLULAR downstream_compartments: - CYTOSOL status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:69729a3800001853 title: Asparagine biosynthetic process 1 (Mouse) n_activities: 3 n_causal_edges: 1 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800001853/69729a3800001921 upstream_label: Nat8l Mmus downstream: gomodel:69729a3800001853/69729a3800001904 downstream_label: Aspa Mmus predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - MITOCHONDRIAL_MATRIX downstream_compartments: - CYTOSOL status: NONADJACENT distance: 4 kind: REGULATION - model: gomodel:69729a3800003258 title: Processing, maturation and transport of oxytocin (OXT) hormone (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800003258/69729a3800003259 upstream_label: OXT-Neurophysin_1 Hsap downstream: gomodel:69729a3800003258/69729a3800003296 downstream_label: OXT-Oxytocin Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:69729a3800003304 title: ' Processing, maturation and transport of vasopressin (AVP) hormone (Human).' n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800003304/69729a3800003305 upstream_label: AVP-Neurophysin_2 Hsap downstream: gomodel:69729a3800003304/69729a3800003350 downstream_label: AVP-Arg-vasopressin Hsap predicate: RO:0002629 predicate_label: directly positively regulates direct: true upstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE - VESICLE_LUMEN - VESICLE_MEMBRANE downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:69729a3800007453 title: protein import into mitochondrial matrix (GO:0030150) n_activities: 27 n_causal_edges: 52 n_unresolved_locations: 0 n_nonadjacent_edges: 3 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800007453/69729a3800007454 upstream_label: tom40 Spom downstream: gomodel:69729a3800007453/69729a3800007642 downstream_label: tim50 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: INPUT - upstream: gomodel:69729a3800007453/69729a3800007454 upstream_label: tom40 Spom downstream: gomodel:69729a3800007453/69729a3800007642 downstream_label: tim50 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: INPUT - upstream: gomodel:69729a3800007453/69729a3800007493 upstream_label: tom22 Spom downstream: gomodel:69729a3800007453/69729a3800007642 downstream_label: tim50 Spom predicate: RO:0002413 predicate_label: directly provides input for direct: true upstream_compartments: - MITOCHONDRIAL_OUTER_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 3 kind: INPUT - model: gomodel:69729a3800008054 title: L-Lysine catabolic process 2 (Mouse) n_activities: 7 n_causal_edges: 5 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800008054/69729a3800008116 upstream_label: Pipox Mmus downstream: gomodel:69729a3800008054/69729a3800008122 downstream_label: Aldh7a1 Mmus predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - PEROXISOME_MATRIX downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 6 kind: REGULATION - model: gomodel:69729a3800008790 title: D-Lysine catabolic process (Mouse) n_activities: 8 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69729a3800008790/69729a3800008816 upstream_label: Pipox Mmus downstream: gomodel:69729a3800008790/69729a3800008817 downstream_label: Aldh7a1 Mmus predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - PEROXISOME_MATRIX downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 6 kind: REGULATION - model: gomodel:698e557b00001137 title: Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). n_activities: 9 n_causal_edges: 9 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:698e557b00001137/698e557b00001250 upstream_label: lysosomal proton-transporting V-type ATPase complex downstream: gomodel:698e557b00001137/698e557b00001328 downstream_label: AXIN1 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - LYSOSOME_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:698e557b00001137/698e557b00001250 upstream_label: lysosomal proton-transporting V-type ATPase complex downstream: gomodel:698e557b00001137/698e557b00001294 downstream_label: AXIN1 Hsap predicate: RO:0002409 predicate_label: indirectly negatively regulates direct: false upstream_compartments: - LYSOSOME_MEMBRANE downstream_compartments: - ENDOSOME_LUMEN - ENDOSOME_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:6994852c00000686 title: Glutamine catabolic process 1 (Mouse) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6994852c00000686/6994852c00000780 upstream_label: Slc38a1 Mmus downstream: gomodel:6994852c00000686/6994852c00000803 downstream_label: Gls Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:6994852c00001892 title: Glutamine catabolic process 3 (Mouse) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6994852c00001892/6994852c00001916 upstream_label: Slc38a1 Mmus downstream: gomodel:6994852c00001892/6994852c00001919 downstream_label: Gls Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:6994852c00001950 title: Glutamine catabolic process 2 (Mouse) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6994852c00001950/6994852c00001960 upstream_label: Slc38a1 Mmus downstream: gomodel:6994852c00001950/6994852c00001961 downstream_label: Gls Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:6994852c00001989 title: Glutamine catabolic process 4 (Mouse) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6994852c00001989/6994852c00002008 upstream_label: Slc38a1 Mmus downstream: gomodel:6994852c00001989/6994852c00002010 downstream_label: Gls Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:6994852c00006613 title: Glutamine catabolic process 6 (Mouse) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6994852c00006613/6994852c00006632 upstream_label: Slc38a1 Mmus downstream: gomodel:6994852c00006613/6994852c00006634 downstream_label: Gls Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:6994852c00006698 title: Glutamine catabolic process 5 (Mouse) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 0 n_nonadjacent_edges: 2 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:6994852c00006698/6994852c00006718 upstream_label: Aldh18a1 Mmus downstream: gomodel:6994852c00006698/6994852c00006720 downstream_label: Pycr3 Mmus predicate: RO:0012009 predicate_label: constitutively upstream of direct: false upstream_compartments: - MITOCHONDRIAL_MATRIX downstream_compartments: - CYTOSOL status: NONADJACENT distance: 4 kind: REGULATION - upstream: gomodel:6994852c00006698/6994852c00006717 upstream_label: Slc38a1 Mmus downstream: gomodel:6994852c00006698/6994852c00006719 downstream_label: Gls Mmus predicate: RO:0002411 predicate_label: causally upstream of direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 5 kind: REGULATION - model: gomodel:69a0c46f00000571 title: Branched-chain amino acid catabolic process 1(Mouse) n_activities: 11 n_causal_edges: 11 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69a0c46f00000571/69a0c46f00000689 upstream_label: Bcat1 Mmus downstream: gomodel:69a0c46f00000571/69a0c46f00000688 downstream_label: protein-containing complex predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 4 kind: REGULATION - model: gomodel:69a0c46f00001110 title: FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69a0c46f00001110/69a0c46f00001352 gene_product: UniProtKB:Q5T035 gene_label: FAM120A2P Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69a0c46f00001110/69a0c46f00001370 gene_product: UniProtKB:Q07955 gene_label: SRSF1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69a0c46f00001390 title: Branched-chain amino acid catabolic process 2(Mouse) n_activities: 13 n_causal_edges: 13 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69a0c46f00001390/69a0c46f00001460 upstream_label: Bcat1 Mmus downstream: gomodel:69a0c46f00001390/69a0c46f00001459 downstream_label: protein-containing complex predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 4 kind: REGULATION - model: gomodel:69a0c46f00001542 title: Branched-chain amino acid catabolic process 3(Mouse) n_activities: 12 n_causal_edges: 12 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69a0c46f00001542/69a0c46f00001612 upstream_label: Bcat1 Mmus downstream: gomodel:69a0c46f00001542/69a0c46f00001611 downstream_label: protein-containing complex predicate: RO:0002304 predicate_label: causally upstream of, positive effect direct: false upstream_compartments: - CYTOSOL downstream_compartments: - MITOCHONDRIAL_MATRIX status: NONADJACENT distance: 4 kind: REGULATION - model: gomodel:69a0c46f00002570 title: Deubiquitination of RAD51 by UCHL3 promotes association between BRA2 and RAD51 and formation of nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69a0c46f00002570/69a0c46f00002571 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69a0c46f00002570/69a0c46f00002580 gene_product: UniProtKB:P51587 gene_label: BRCA2 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:69a0c46f00002608 title: FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69a0c46f00002608/69a0c46f00002642 gene_product: UniProtKB:Q9NSG2 gene_label: FIRRM Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69a0c46f00002608/69a0c46f00002650 gene_product: UniProtKB:P51587 gene_label: BRCA2 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69a0c46f00002608/69a0c46f00002630 gene_product: UniProtKB:Q6PIW4 gene_label: FIGNL1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69a0c46f00002608/69a0c46f00002609 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:69a0c46f00002668 title: Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 4 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69a0c46f00002668/69a0c46f00002669 gene_product: UniProtKB:Q9NQV7 gene_label: PRDM9 Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69a0c46f00002668/69a0c46f00002674 gene_product: UniProtKB:Q9Y5K1 gene_label: SPO11 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69a0c46f00002668/69a0c46f00002694 gene_product: UniProtKB:Q06609 gene_label: RAD51 Hsap occurs_in: GO:0035861 occurs_in_label: site of double-strand break status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69a0c46f00002668/69a0c46f00002685 gene_product: UniProtKB:Q14565 gene_label: DMC1 Hsap occurs_in: GO:0005694 occurs_in_label: chromosome status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:69b3372b00000379 title: cellular response to copper ion starvation (GO:0035874) n_activities: 12 n_causal_edges: 17 n_unresolved_locations: 0 n_nonadjacent_edges: 4 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69b3372b00000379/69b3372b00000429 upstream_label: cuf1 Spom downstream: gomodel:69b3372b00000379/69b3372b00000415 downstream_label: ctr6 Spom predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - VACUOLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:69b3372b00000379/69b3372b00000429 upstream_label: cuf1 Spom downstream: gomodel:69b3372b00000379/69b3372b00000415 downstream_label: ctr6 Spom predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - VACUOLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:69b3372b00000379/69b3372b00000429 upstream_label: cuf1 Spom downstream: gomodel:69b3372b00000379/69b3372b00000392 downstream_label: copper ion transmembrane transporter complex predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - PLASMA_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - upstream: gomodel:69b3372b00000379/69b3372b00000429 upstream_label: cuf1 Spom downstream: gomodel:69b3372b00000379/69b3372b00000415 downstream_label: ctr6 Spom predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - VACUOLE_MEMBRANE status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:69b3372b00001688 title: Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69b3372b00001688/69b3372b00001734 gene_product: UniProtKB:Q8IW35 gene_label: CEP97 Hsap occurs_in: GO:0005813 occurs_in_label: centrosome status: UNRESOLVED compartments: [] hint: term: GO:0005813 label: centrosome usual: CYTOSOL edges: [] - model: gomodel:69b3372b00001963 title: MDM2-UBE4B cooperation to ubiquitinate P53 (Human) n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69b3372b00001963/69b3372b00001985 gene_product: UniProtKB:P04637 gene_label: TP53 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69b3372b00003343 title: FSH delivery to granulosa cells promotes follicle development (Human) n_activities: 7 n_causal_edges: 6 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69b3372b00003343/69c59f8a00001719 upstream_label: GNAS Hsap downstream: gomodel:69b3372b00003343/6a2b236300000864 downstream_label: PRKACA Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - PLASMA_MEMBRANE downstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN status: NONADJACENT distance: 2 kind: REGULATION - model: gomodel:69c59f8a00000219 title: 'CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA ' n_activities: 9 n_causal_edges: 10 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69c59f8a00000219/69c59f8a00000304 gene_product: UniProtKB:Q96AE4 gene_label: FUBP1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69c59f8a00000219/69c59f8a00000321 gene_product: UniProtKB:Q92831 gene_label: KAT2B Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69c59f8a00001359 title: KRT15 negative regulation of Hippo signaling via YAP1_OFF state_Human n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69c59f8a00001359/69c59f8a00001363 gene_product: UniProtKB:P19012 gene_label: KRT15 Hsap occurs_in: GO:0045095 occurs_in_label: keratin filament status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:69c59f8a00002811 title: KRT14 positive regulation of Hippo signaling via YAP1_ON state_Human n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69c59f8a00002811/69c59f8a00002815 gene_product: UniProtKB:P02533 gene_label: KRT14 Hsap occurs_in: GO:0045095 occurs_in_label: keratin filament status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:69d8496c00000318 title: 'CDKN1A/WAF1/CIP1/p21 induction via HIPK2 ' n_activities: 5 n_causal_edges: 5 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00000318/69d8496c00000390 gene_product: UniProtKB:Q92831 gene_label: KAT2B Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00001461 title: IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). n_activities: 10 n_causal_edges: 9 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00001461/69d8496c00001508 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69d8496c00001461/69d8496c00001500 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00001576 title: STING1 promotes NF-kappa-B signaling in response to virus infection (Human). n_activities: 11 n_causal_edges: 10 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00001576/69d8496c00001623 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69d8496c00001576/69d8496c00001615 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00001701 title: Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). n_activities: 11 n_causal_edges: 10 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00001701/69d8496c00001748 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69d8496c00001701/69d8496c00001740 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00003234 title: FBXO42-mediated degradation of PPP4C via CUL1 (Human) n_activities: 4 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00003234/69ea894900000659 gene_product: UniProtKB:P60510 gene_label: PPP4C Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00003493 title: HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). n_activities: 10 n_causal_edges: 9 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00003493/69d8496c00003532 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69d8496c00003493/69d8496c00003540 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00004472 title: PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). n_activities: 12 n_causal_edges: 11 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00004472/69d8496c00004519 gene_product: UniProtKB:Q04206 gene_label: RELA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. - activity_id: gomodel:69d8496c00004472/69d8496c00004511 gene_product: UniProtKB:P19838 gene_label: NFKB1 Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69d8496c00005490 title: In macrophages, octanal activates OR6A2-mediated signaling via G-alpha-s ("stimulatory", activating adenylate cyclase), promoting NLRP3 inflammasome assembly (Human). n_activities: 4 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69d8496c00005490/69d8496c00005530 gene_product: UniProtKB:Q96P20 gene_label: NLRP3 Hsap occurs_in: GO:0005815 occurs_in_label: microtubule organizing center status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:69ea894900000181 title: PARP1 stabilizes AFF1 involved in transcriptional restart after DNA damage (Human) n_activities: 3 n_causal_edges: 2 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69ea894900000181/69ea894900000182 gene_product: UniProtKB:P09874 gene_label: PARP1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 - activity_id: gomodel:69ea894900000181/69ea894900000245 gene_product: UniProtKB:P51825 gene_label: AFF1 Hsap occurs_in: GO:0090734 occurs_in_label: site of DNA damage status: UNRESOLVED compartments: [] hint: term: GO:0005694 label: chromosome usual: NUCLEAR_LUMEN better_term: *id002 edges: [] - model: gomodel:69ea894900000468 title: Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69ea894900000468/69ea894900000509 gene_product: UniProtKB:P24844 gene_label: MYL9 Hsap occurs_in: GO:0005856 occurs_in_label: cytoskeleton status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:69ea894900000668 title: FBXO42-mediated degradation of PPP2C via CUL1 (Human) n_activities: 5 n_causal_edges: 4 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69ea894900000668/69ea894900000707 gene_product: UniProtKB:P67775 gene_label: PPP2CA Hsap occurs_in: GO:0000785 occurs_in_label: chromatin status: UNRESOLVED compartments: [] hint: term: GO:0000785 label: chromatin usual: NUCLEAR_LUMEN better_term: *id001 note: GO places chromatin under chromosome, which is not part of the nucleus because prokaryotic chromosomes exist. edges: [] - model: gomodel:69ea894900001492 title: Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) n_activities: 5 n_causal_edges: 1 n_unresolved_locations: 0 n_nonadjacent_edges: 1 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: [] edges: - upstream: gomodel:69ea894900001492/69ea894900002007 upstream_label: ATOX1 Hsap downstream: gomodel:69ea894900001492/69ea894900001980 downstream_label: SOD3 Hsap predicate: RO:0002407 predicate_label: indirectly positively regulates direct: false upstream_compartments: - NUCLEAR_ENVELOPE - NUCLEAR_LUMEN downstream_compartments: - EXTRACELLULAR status: NONADJACENT distance: 3 kind: REGULATION - model: gomodel:69ea894900003185 title: Negative regulation of nitric oxide synthase activity (Mouse) n_activities: 5 n_causal_edges: 3 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:69ea894900003185/69ea894900003460 gene_product: MGI:MGI:1913644 gene_label: Nosip Mmus occurs_in: GO:0015629 occurs_in_label: actin cytoskeleton status: UNRESOLVED compartments: [] hint: term: GO:0015629 label: actin cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:MGI_MGI_109482 title: Cacna1a (MGI:MGI:109482) n_activities: 132 n_causal_edges: 5 n_unresolved_locations: 21 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:MGI_MGI_109482/0824ab99-0b0a-4566-b537-5680eacd49c5 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/199a8fa7-ef55-4c20-bdf5-d52d427a8e34 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000120 occurs_in_label: granule cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/0824ab99-0b0a-4566-b537-5680eacd49c5-3 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/08e62d5b-a1ee-4af4-8697-7b023efb1b63 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/08e62d5b-a1ee-4af4-8697-7b023efb1b63-3 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/556a3c8c-a6b8-4f9d-acb0-73130ebe75d1-2 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/64c3044100000271 gene_product: MGI:MGI:88297 gene_label: Cck Mmus occurs_in: EMAPA:17787 occurs_in_label: cerebellum status: UNRESOLVED compartments: [] - activity_id: gomodel:MGI_MGI_109482/2c50e6be-116e-401c-8fd5-66fb64e24cb5 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/0824ab99-0b0a-4566-b537-5680eacd49c5-2 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/eb6fdb39-96e2-412d-afc2-883fbd90004d gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000100 occurs_in_label: motor neuron status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/be9f6321-c972-42c5-9ee7-1a235934e2a5 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000166 occurs_in_label: chromaffin cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/08e62d5b-a1ee-4af4-8697-7b023efb1b63-2 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/429868f2-dda7-49d1-9f9d-865d08aa3595 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000100 occurs_in_label: motor neuron status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/fa4fb88b-e64d-4b93-8fca-7103e18c0c80 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000117 occurs_in_label: CNS neuron (sensu Vertebrata) status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/8bebec09-9f6a-4d49-b49b-e748aceb6083 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000336 occurs_in_label: adrenal medulla chromaffin cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/9bdc95dd-223a-4e0b-a033-8d04c0ce1054 gene_product: MGI:MGI:98326 gene_label: Sst Mmus occurs_in: EMAPA:16910 occurs_in_label: telencephalon status: UNRESOLVED compartments: [] - activity_id: gomodel:MGI_MGI_109482/7cfdd11e-8505-4e0f-8262-920ea4191116 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000100 occurs_in_label: motor neuron status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/d32e1d65-ffa1-420b-a256-2e7d947d0275 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: EMAPA:35840 occurs_in_label: superior olivary nucleus status: UNRESOLVED compartments: [] - activity_id: gomodel:MGI_MGI_109482/556a3c8c-a6b8-4f9d-acb0-73130ebe75d1 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000121 occurs_in_label: Purkinje cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/ca36ab24-9d8f-4cf7-860e-1c2f223f3ca1 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000120 occurs_in_label: granule cell status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. - activity_id: gomodel:MGI_MGI_109482/3ba45e6a-6a58-4e91-8e46-e8c3664668b3 gene_product: MGI:MGI:109482 gene_label: Cacna1a Mmus occurs_in: CL:0000540 occurs_in_label: neuron status: UNRESOLVED compartments: [] hint: note: occurs_in names a cell type (CL), which says which cell but not where in it; add a cellular component. edges: [] - model: gomodel:MGI_MGI_2180566 title: Meiosis 1 (Mouse) n_activities: 3 n_causal_edges: 0 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:MGI_MGI_2180566/641ce4dc00000342 gene_product: MGI:MGI:1861437 gene_label: Gsk3b Mmus occurs_in: GO:0072687 occurs_in_label: meiotic spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL - activity_id: gomodel:MGI_MGI_2180566/19a504e3-f540-47a6-aca1-775bb7a1d30e gene_product: MGI:MGI:2180566 gene_label: Pnma5 Mmus occurs_in: GO:0072687 occurs_in_label: meiotic spindle status: UNRESOLVED compartments: [] hint: term: GO:0005856 label: cytoskeleton usual: CYTOSOL edges: [] - model: gomodel:SGD_S000001043 title: OSH7 (SGD:S000001043) n_activities: 33 n_causal_edges: 0 n_unresolved_locations: 2 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:SGD_S000001043/6918f23700001179 gene_product: SGD:S000001043 gene_label: OSH7 Scer occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. - activity_id: gomodel:SGD_S000001043/6918f23700001168 gene_product: SGD:S000001043 gene_label: OSH7 Scer occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: [] - model: gomodel:SGD_S000001711 title: OSH6 (SGD:S000001711) n_activities: 38 n_causal_edges: 0 n_unresolved_locations: 1 n_nonadjacent_edges: 0 n_bridged_edges: 0 n_relocating_edges: 0 n_explained_edges: 0 locations: - activity_id: gomodel:SGD_S000001711/6918f23700001147 gene_product: SGD:S000001711 gene_label: OSH6 Scer occurs_in: GO:0140268 occurs_in_label: endoplasmic reticulum-plasma membrane contact site status: UNRESOLVED compartments: [] hint: term: GO:0044232 label: organelle membrane contact site note: a contact site joins two membranes across the cytosol; name the membrane the activity is in. edges: []