description: Candidate members of the primary cilium life-cycle module. Stage and role are curated; uniprot and protein_name come from the UniProt REST API (reviewed human entries, gene_exact search). members: - stage: 1_basal_body_licensing gene: CEP83 uniprot: Q9Y592 protein_name: Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (Renal carcinoma antigen NY-REN-58) role: distal appendage root component - stage: 1_basal_body_licensing gene: SCLT1 uniprot: Q96NL6 protein_name: Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1) role: distal appendage component - stage: 1_basal_body_licensing gene: CEP89 uniprot: Q96ST8 protein_name: Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) role: distal appendage component - stage: 1_basal_body_licensing gene: FBF1 uniprot: Q8TES7 protein_name: Fas-binding factor 1 (FBF-1) (Protein albatross) role: distal appendage component - stage: 1_basal_body_licensing gene: CEP164 uniprot: Q9UPV0 protein_name: Centrosomal protein of 164 kDa (Cep164) role: distal appendage component; TTBK2 recruitment - stage: 1_basal_body_licensing gene: TTBK2 uniprot: Q6IQ55 protein_name: Tau-tubulin kinase 2 (EC 2.7.11.1) role: kinase removing CP110-CEP97 cap - stage: 1_basal_body_licensing gene: CCP110 uniprot: O43303 protein_name: Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) role: distal centriole cap (ciliogenesis suppressor) - stage: 1_basal_body_licensing gene: CEP97 uniprot: Q8IW35 protein_name: Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) role: distal centriole cap partner - stage: 1_basal_body_licensing gene: KIF24 uniprot: Q5T7B8 protein_name: Kinesin-like protein KIF24 role: MT-depolymerizing kinesin at mother centriole (ciliogenesis suppressor) - stage: 1_basal_body_licensing gene: MPHOSPH9 uniprot: Q99550 protein_name: M-phase phosphoprotein 9 role: distal centriole cap recruiter of CP110-CEP97 - stage: 2_ciliary_vesicle gene: MYO5A uniprot: Q9Y4I1 protein_name: Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) role: preciliary vesicle transport to distal appendages - stage: 2_ciliary_vesicle gene: EHD1 uniprot: Q9H4M9 protein_name: EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) role: ciliary vesicle formation - stage: 2_ciliary_vesicle gene: EHD3 uniprot: Q9NZN3 protein_name: EH domain-containing protein 3 (PAST homolog 3) role: ciliary vesicle formation - stage: 2_ciliary_vesicle gene: PACSIN1 uniprot: Q9BY11 protein_name: Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) role: ciliary vesicle tubulation - stage: 2_ciliary_vesicle gene: RAB11A uniprot: P62491 protein_name: Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) role: Rab cascade upstream GTPase - stage: 2_ciliary_vesicle gene: RAB3IP uniprot: Q96QF0 protein_name: Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein) role: Rabin8; RAB8 GEF - stage: 2_ciliary_vesicle gene: RAB8A uniprot: P61006 protein_name: Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) role: ciliary membrane delivery GTPase - stage: 3_transition_zone gene: CEP290 uniprot: O15078 protein_name: Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) role: transition zone scaffold - stage: 3_transition_zone gene: MKS1 uniprot: Q9NXB0 protein_name: Tectonic-like complex member MKS1 (Meckel syndrome type 1 protein) role: MKS module - stage: 3_transition_zone gene: TMEM67 uniprot: Q5HYA8 protein_name: Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67) role: MKS module - stage: 3_transition_zone gene: CC2D2A uniprot: Q9P2K1 protein_name: Coiled-coil and C2 domain-containing protein 2A role: MKS module - stage: 3_transition_zone gene: B9D1 uniprot: Q9UPM9 protein_name: B9 domain-containing protein 1 (MKS1-related protein 1) role: MKS module - stage: 3_transition_zone gene: B9D2 uniprot: Q9BPU9 protein_name: B9 domain-containing protein 2 (MKS1-related protein 2) role: MKS module - stage: 3_transition_zone gene: TCTN1 uniprot: Q2MV58 protein_name: Tectonic-1 role: MKS module - stage: 3_transition_zone gene: TCTN2 uniprot: Q96GX1 protein_name: Tectonic-2 role: MKS module - stage: 3_transition_zone gene: TMEM216 uniprot: Q9P0N5 protein_name: Transmembrane protein 216 role: MKS module - stage: 3_transition_zone gene: TMEM231 uniprot: Q9H6L2 protein_name: Transmembrane protein 231 role: MKS module - stage: 3_transition_zone gene: NPHP1 uniprot: O15259 protein_name: Nephrocystin-1 (Juvenile nephronophthisis 1 protein) role: NPHP module - stage: 3_transition_zone gene: NPHP4 uniprot: O75161 protein_name: Nephrocystin-4 (Nephroretinin) role: NPHP module - stage: 3_transition_zone gene: RPGRIP1L uniprot: Q68CZ1 protein_name: Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) role: NPHP module - stage: 3_transition_zone gene: AHI1 uniprot: Q8N157 protein_name: Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) role: transition zone - stage: 4_axoneme_extension_ift gene: IFT88 uniprot: Q13099 protein_name: Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737 homolog) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) role: IFT-B core - stage: 4_axoneme_extension_ift gene: IFT52 uniprot: Q9Y366 protein_name: Intraflagellar transport protein 52 homolog (Protein NGD5 homolog) role: IFT-B core - stage: 4_axoneme_extension_ift gene: IFT81 uniprot: Q8WYA0 protein_name: Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) role: IFT-B core; tubulin binding - stage: 4_axoneme_extension_ift gene: IFT74 uniprot: Q96LB3 protein_name: Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) role: IFT-B core; tubulin binding - stage: 4_axoneme_extension_ift gene: IFT172 uniprot: Q9UG01 protein_name: Intraflagellar transport protein 172 homolog role: IFT-B peripheral - stage: 4_axoneme_extension_ift gene: IFT140 uniprot: Q96RY7 protein_name: Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) role: IFT-A - stage: 4_axoneme_extension_ift gene: IFT122 uniprot: Q9HBG6 protein_name: Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140) role: IFT-A - stage: 4_axoneme_extension_ift gene: WDR35 uniprot: Q9P2L0 protein_name: WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog) role: IFT-A - stage: 4_axoneme_extension_ift gene: TTC21B uniprot: Q7Z4L5 protein_name: Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) role: IFT-A - stage: 4_axoneme_extension_ift gene: KIF3A uniprot: Q9Y496 protein_name: Kinesin-like protein KIF3A (EC 3.6.4.-) (Microtubule plus end-directed kinesin motor 3A) role: kinesin-2 motor - stage: 4_axoneme_extension_ift gene: KIF3B uniprot: O15066 protein_name: 'Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]' role: kinesin-2 motor - stage: 4_axoneme_extension_ift gene: KIFAP3 uniprot: Q92845 protein_name: Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) role: kinesin-2 accessory - stage: 4_axoneme_extension_ift gene: KIF17 uniprot: Q9P2E2 protein_name: Kinesin-like protein KIF17 (KIF3-related motor protein) role: homodimeric kinesin-2 - stage: 4_axoneme_extension_ift gene: DYNC2H1 uniprot: Q8NCM8 protein_name: Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B) role: dynein-2 heavy chain - stage: 4_axoneme_extension_ift gene: DYNC2LI1 uniprot: Q8TCX1 protein_name: Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 2 light intermediate chain) role: dynein-2 light intermediate chain - stage: 4_axoneme_extension_ift gene: DYNC2I1 uniprot: Q8WVS4 protein_name: Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) role: dynein-2 intermediate chain (WDR60) - stage: 4_axoneme_extension_ift gene: DYNC2I2 uniprot: Q96EX3 protein_name: Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34) role: dynein-2 intermediate chain (WDR34) - stage: 5_membrane_composition gene: ARL13B uniprot: Q3SXY8 protein_name: ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) role: ciliary membrane GTPase; ARL3 GEF - stage: 5_membrane_composition gene: ARL3 uniprot: P36405 protein_name: ADP-ribosylation factor-like protein 3 role: ciliary cargo release GTPase - stage: 5_membrane_composition gene: INPP5E uniprot: Q9NRR6 protein_name: Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) role: ciliary phosphoinositide phosphatase - stage: 5_membrane_composition gene: TULP3 uniprot: O75386 protein_name: Tubby-related protein 3 (Tubby-like protein 3) role: IFT-A adaptor for membrane protein entry - stage: 5_membrane_composition gene: PDE6D uniprot: O43924 protein_name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) role: lipidated cargo carrier - stage: 5_membrane_composition gene: UNC119B uniprot: A6NIH7 protein_name: Protein unc-119 homolog B role: myristoylated cargo carrier - stage: 5_membrane_composition gene: RP2 uniprot: O75695 protein_name: Protein XRP2 role: ARL3 GAP - stage: 5_membrane_composition gene: BBS1 uniprot: Q8NFJ9 protein_name: BBSome complex member BBS1 (BBS2-like protein 2) (Bardet-Biedl syndrome 1 protein) role: BBSome (see modules/bbsome.yaml) - stage: 5_membrane_composition gene: LZTFL1 uniprot: Q9NQ48 protein_name: Leucine zipper transcription factor-like protein 1 role: BBSome regulator - stage: 6_length_control gene: CILK1 uniprot: Q9UPZ9 protein_name: Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) role: ciliary length kinase (ICK) - stage: 6_length_control gene: MAK uniprot: P20794 protein_name: Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase) role: ciliary length kinase - stage: 6_length_control gene: KIF7 uniprot: Q2M1P5 protein_name: Kinesin-like protein KIF7 role: ciliary tip length regulator - stage: 7_disassembly gene: AURKA uniprot: O14965 protein_name: Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) role: ciliary disassembly kinase - stage: 7_disassembly gene: NEDD9 uniprot: Q14511 protein_name: 'Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]' role: AURKA activator (HEF1) - stage: 7_disassembly gene: HDAC6 uniprot: Q9UBN7 protein_name: Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) role: axonemal tubulin deacetylase - stage: 7_disassembly gene: PLK1 uniprot: P53350 protein_name: Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) role: disassembly kinase - stage: 7_disassembly gene: KIF2A uniprot: O00139 protein_name: Kinesin-like protein KIF2A (Kinesin-2) (hK2) role: MT depolymerase at basal body - stage: 7_disassembly gene: CIMAP3 uniprot: Q8TCI5 protein_name: Ciliary microtubule-associated protein 3 (Protein pitchfork) role: Pitchfork (CIMAP3); AURKA activator - stage: 7_disassembly gene: DYNLT1 uniprot: P63172 protein_name: Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) role: Tctex-1; resorption - stage: 7_disassembly gene: OFD1 uniprot: O75665 protein_name: Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) role: centriolar satellite/distal centriole; autophagy link