Hypochlorous acid process term obsoletion

GO:0002148, GO:0002149, GO:0002150: all three now obsolete

AI Gene Review · projects/HYPOCHLOROUS_ACID_OBSOLETION · reviewed 2026-10-04

Bottom line

  • GO obsoleted all three HOCl process terms; the two children because each "represents a MF term".
  • Only one experimental row is affected: mouse Mpo IMP (PMID:10085024), plus a rat ISO copy.
  • Tracked in #4098: Mpo is not reviewed here, and the MF anchor an earlier draft proposed (GO:0140825) is lactoperoxidase activity in OLS, so the HOCl-forming MF still needs to be found.

Where HOCl comes from

The three terms

Why the terms went

  • GO:0002148 sat under organic acid metabolic process; HOCl has no carbon (go-ontology#22891).
  • HOCl formation is one reaction by one enzyme, so a process term only restates the activity.
  • The catabolic term had no direct protein annotations.
  • The annotation ticket is still open; the Mpo row needs an MF decision.

Next steps

  1. Watch go-annotation#6404 until the mouse Mpo target settles.
  2. Find the GO MF term for HOCl-forming peroxidase activity (RHEA:43232) with OLS; do not reuse GO:0140825 without checking.
  3. Then just fetch-gene mouse Mpo; the rat ISO row follows the mouse row, and human MPO is optional.

Local: ai-gene-review#4098
Upstream: go-annotation#6404 · go-ontology#22891 · go-ontology#30524
Read more: projects/HYPOCHLOROUS_ACID_OBSOLETION.md