ICAM-3 receptor activity obsoletion

GO:0030369 → GO:0004888 + has_input ICAM3

AI Gene Review · projects/ICAM3_RECEPTOR_ACTIVITY_OBSOLETION · 2026

Bottom line

  • GO obsoleted GO:0030369 because ICAM3 binds several unrelated receptors; one ligand-named term fits none of them precisely.
  • 3 human rows move to GO:0004888 with the ligand as an extension: ITGAL, ITGB2 (IMP) and CLEC4M (NAS); ~155 IEA rows follow.
  • Scoped, not yet started: none of these genes is reviewed here; CLEC4M's NAS row is the one to question.

One ligand, unrelated receptors

Old term → proposed home

Why a ligand-named term fails

  • Integrins LFA-1 (ITGAL:ITGB2) and αD/β2 bind the ICAM3 protein.
  • C-type lectins CLEC4M and CD209 bind its high-mannose glycans.
  • OLS obsoletion note: the term is "more specific than the specificity of any known gene product".
  • The receptor activity stays in GO:0004888; has_input records the ligand, as in GO-CAM.

Next steps

  1. Review ITGAL and ITGB2 together (shared PMID:19029120); LFA-1's core MF is adhesion-molecule binding.
  2. Then CLEC4M: check whether PMID:11257134 supports an ICAM3 receptor claim; D-mannose binding (GO:0005537) is the likely core.
  3. Optional: CD209, ITGAD, ICAM3 itself.

Upstream: go-annotation#6442 · go-ontology#30560
Read more: projects/ICAM3_RECEPTOR_ACTIVITY_OBSOLETION.md