species	taxon	symbol	label	family	module	accession	status	n_hits	primary_name_match	reference_proteome	protein_name	review_exists
human	9606	TLR1	TLR1	TLR	Toll-like receptor signaling	Q15399	reviewed	1	yes	yes	Toll-like receptor 1	yes
human	9606	TLR2	TLR2	TLR	Toll-like receptor signaling	O60603	reviewed	1	yes	yes	Toll-like receptor 2	yes
human	9606	TLR3	TLR3	TLR	Toll-like receptor signaling	O15455	reviewed	1	yes	yes	Toll-like receptor 3	yes
human	9606	TLR4	TLR4	TLR	Toll-like receptor signaling	O00206	reviewed	1	yes	yes	Toll-like receptor 4	yes
human	9606	TLR5	TLR5	TLR	Toll-like receptor signaling	O60602	reviewed	1	yes	yes	Toll-like receptor 5	yes
human	9606	TLR6	TLR6	TLR	Toll-like receptor signaling	Q9Y2C9	reviewed	1	yes	yes	Toll-like receptor 6	yes
human	9606	TLR7	TLR7	TLR	Toll-like receptor signaling	Q9NYK1	reviewed	1	yes	yes	Toll-like receptor 7	yes
human	9606	TLR8	TLR8	TLR	Toll-like receptor signaling	Q9NR97	reviewed	1	yes	yes	Toll-like receptor 8	yes
human	9606	TLR9	TLR9	TLR	Toll-like receptor signaling	Q9NR96	reviewed	1	yes	yes	Toll-like receptor 9	yes
human	9606	TLR10	TLR10	TLR	Toll-like receptor signaling	Q9BXR5	reviewed	1	yes	yes	Toll-like receptor 10	yes
human	9606	CD14	CD14	TLR accessory	Toll-like receptor signaling	P08571	reviewed	1	yes	yes	Monocyte differentiation antigen CD14	yes
human	9606	LY96	LY96	TLR accessory	Toll-like receptor signaling	Q9Y6Y9	reviewed	1	yes	yes	Lymphocyte antigen 96	yes
human	9606	LBP	LBP	TLR accessory	Toll-like receptor signaling	P18428	reviewed	1	yes	yes	Lipopolysaccharide-binding protein	no
human	9606	UNC93B1	UNC93B1	TLR accessory	Toll-like receptor signaling	Q9H1C4	reviewed	1	yes	yes	Protein unc-93 homolog B1	yes
human	9606	MYD88	MYD88	TIR adaptor	Toll-like receptor signaling	Q99836	reviewed	1	yes	yes	Myeloid differentiation primary response protein MyD88	yes
human	9606	TIRAP	TIRAP	TIR adaptor	Toll-like receptor signaling	P58753	reviewed	1	yes	yes	Toll/interleukin-1 receptor domain-containing adapter protein	yes
human	9606	TICAM1	TICAM1	TIR adaptor	Toll-like receptor signaling	Q8IUC6	reviewed	1	yes	yes	TIR domain-containing adapter molecule 1	yes
human	9606	TICAM2	TICAM2	TIR adaptor	Toll-like receptor signaling	Q86XR7	reviewed	1	yes	yes	TIR domain-containing adapter molecule 2	no
human	9606	SARM1	SARM1	TIR adaptor	Toll-like receptor signaling	Q6SZW1	reviewed	1	yes	yes	NAD(+) hydrolase SARM1	no
human	9606	IRAK1	IRAK1	IRAK	Toll-like receptor signaling	P51617	reviewed	1	yes	yes	Interleukin-1 receptor-associated kinase 1	no
human	9606	IRAK2	IRAK2	IRAK	Toll-like receptor signaling	O43187	reviewed	1	yes	yes	Interleukin-1 receptor-associated kinase-like 2	no
human	9606	IRAK3	IRAK3	IRAK	Toll-like receptor signaling	Q9Y616	reviewed	1	yes	yes	Interleukin-1 receptor-associated kinase 3	yes
human	9606	IRAK4	IRAK4	IRAK	Toll-like receptor signaling	Q9NWZ3	reviewed	1	yes	yes	Interleukin-1 receptor-associated kinase 4	yes
human	9606	TRAF3	TRAF3	TRAF	Toll-like receptor signaling	Q13114	reviewed	1	yes	yes	TNF receptor-associated factor 3	yes
human	9606	TRAF6	TRAF6	TRAF	Toll-like receptor signaling	Q9Y4K3	reviewed	1	yes	yes	TNF receptor-associated factor 6	yes
human	9606	MAP3K7	MAP3K7	kinase relay	NF-kappaB / IRF output	O43318	reviewed	1	yes	yes	Mitogen-activated protein kinase kinase kinase 7	no
human	9606	TAB1	TAB1	kinase relay	NF-kappaB / IRF output	Q15750	reviewed	1	yes	yes	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	no
human	9606	TAB2	TAB2	kinase relay	NF-kappaB / IRF output	Q9NYJ8	reviewed	1	yes	yes	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	no
human	9606	CHUK	CHUK	kinase relay	NF-kappaB / IRF output	O15111	reviewed	1	yes	yes	Inhibitor of nuclear factor kappa-B kinase subunit alpha	no
human	9606	IKBKB	IKBKB	kinase relay	NF-kappaB / IRF output	O14920	reviewed	1	yes	yes	Inhibitor of nuclear factor kappa-B kinase subunit beta	no
human	9606	IKBKG	IKBKG	kinase relay	NF-kappaB / IRF output	Q9Y6K9	reviewed	1	yes	yes	NF-kappa-B essential modulator	no
human	9606	TBK1	TBK1	kinase relay	NF-kappaB / IRF output	Q9UHD2	reviewed	1	yes	yes	Serine/threonine-protein kinase TBK1	yes
human	9606	IKBKE	IKBKE	kinase relay	NF-kappaB / IRF output	Q14164	reviewed	1	yes	yes	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	no
human	9606	RELA	RELA	NF-kappaB/Rel	NF-kappaB / IRF output	Q04206	reviewed	1	yes	yes	Transcription factor p65	no
human	9606	NFKB1	NFKB1	NF-kappaB/Rel	NF-kappaB / IRF output	P19838	reviewed	1	yes	yes	Nuclear factor NF-kappa-B p105 subunit	no
human	9606	NFKBIA	NFKBIA	NF-kappaB/Rel	NF-kappaB / IRF output	P25963	reviewed	1	yes	yes	NF-kappa-B inhibitor alpha	no
human	9606	IRF3	IRF3	IRF	NF-kappaB / IRF output	Q14653	reviewed	1	yes	yes	Interferon regulatory factor 3	no
human	9606	IRF5	IRF5	IRF	NF-kappaB / IRF output	Q13568	reviewed	1	yes	yes	Interferon regulatory factor 5	no
human	9606	IRF7	IRF7	IRF	NF-kappaB / IRF output	Q92985	reviewed	1	yes	yes	Interferon regulatory factor 7	no
human	9606	TOLLIP	TOLLIP	negative regulator	NF-kappaB / IRF output	Q9H0E2	reviewed	1	yes	yes	Toll-interacting protein	yes
human	9606	TNFAIP3	TNFAIP3	negative regulator	NF-kappaB / IRF output	P21580	reviewed	1	yes	yes	Tumor necrosis factor alpha-induced protein 3	yes
human	9606	NOD1	NOD1	NLR	NLR signaling and inflammasomes	Q9Y239	reviewed	1	yes	yes	Nucleotide-binding oligomerization domain-containing protein 1	no
human	9606	NOD2	NOD2	NLR	NLR signaling and inflammasomes	Q9HC29	reviewed	1	yes	yes	Nucleotide-binding oligomerization domain-containing protein 2	no
human	9606	NLRP1	NLRP1	NLR	NLR signaling and inflammasomes	Q9C000	reviewed	1	yes	yes	NACHT, LRR and PYD domains-containing protein 1	no
human	9606	NLRP3	NLRP3	NLR	NLR signaling and inflammasomes	Q96P20	reviewed	1	yes	yes	NACHT, LRR and PYD domains-containing protein 3	yes
human	9606	NLRC4	NLRC4	NLR	NLR signaling and inflammasomes	Q9NPP4	reviewed	1	yes	yes	NLR family CARD domain-containing protein 4	no
human	9606	NAIP	NAIP	NLR	NLR signaling and inflammasomes	Q13075	reviewed	1	yes	yes	Baculoviral IAP repeat-containing protein 1	no
human	9606	NLRP6	NLRP6	NLR	NLR signaling and inflammasomes	P59044	reviewed	1	yes	yes	NACHT, LRR and PYD domains-containing protein 6	no
human	9606	CARD8	CARD8	NLR	NLR signaling and inflammasomes	Q9Y2G2	reviewed	1	yes	yes	Caspase recruitment domain-containing protein 8	no
human	9606	RIPK2	RIPK2	inflammasome component	NLR signaling and inflammasomes	O43353	reviewed	1	yes	yes	Receptor-interacting serine/threonine-protein kinase 2	no
human	9606	PYCARD	PYCARD	inflammasome component	NLR signaling and inflammasomes	Q9ULZ3	reviewed	1	yes	yes	Apoptosis-associated speck-like protein containing a CARD	no
human	9606	AIM2	AIM2	inflammasome component	NLR signaling and inflammasomes	O14862	reviewed	1	yes	yes	Interferon-inducible protein AIM2	no
human	9606	CASP1	CASP1	inflammasome component	NLR signaling and inflammasomes	P29466	reviewed	1	yes	yes	Caspase-1	no
human	9606	CASP4	CASP4	inflammasome component	NLR signaling and inflammasomes	P49662	reviewed	1	yes	yes	Caspase-4	yes
human	9606	GSDMD	GSDMD	inflammasome component	NLR signaling and inflammasomes	P57764	reviewed	1	yes	yes	Gasdermin-D	yes
human	9606	IL1B	IL1B	inflammasome component	NLR signaling and inflammasomes	P01584	reviewed	1	yes	yes	Interleukin-1 beta	no
human	9606	IL18	IL18	inflammasome component	NLR signaling and inflammasomes	Q14116	reviewed	1	yes	yes	Interleukin-18	no
human	9606	RIGI	RIGI	RLR	Cytosolic nucleic-acid sensing	O95786	reviewed	1	yes	yes	Antiviral innate immune response receptor RIG-I	no
human	9606	IFIH1	IFIH1	RLR	Cytosolic nucleic-acid sensing	Q9BYX4	reviewed	1	yes	yes	Interferon-induced helicase C domain-containing protein 1	yes
human	9606	DHX58	DHX58	RLR	Cytosolic nucleic-acid sensing	Q96C10	reviewed	1	yes	yes	ATP-dependent RNA helicase DHX58	no
human	9606	MAVS	MAVS	RLR	Cytosolic nucleic-acid sensing	Q7Z434	reviewed	1	yes	yes	Mitochondrial antiviral-signaling protein	no
human	9606	TRIM25	TRIM25	RLR	Cytosolic nucleic-acid sensing	Q14258	reviewed	1	yes	yes	E3 ubiquitin/ISG15 ligase TRIM25	no
human	9606	CGAS	CGAS	cGLR/STING	Cytosolic nucleic-acid sensing	Q8N884	reviewed	1	yes	yes	Cyclic GMP-AMP synthase	no
human	9606	STING1	STING1	cGLR/STING	Cytosolic nucleic-acid sensing	Q86WV6	reviewed	1	yes	yes	Stimulator of interferon genes protein	yes
human	9606	ZBP1	ZBP1	cGLR/STING	Cytosolic nucleic-acid sensing	Q9H171	reviewed	1	yes	yes	Z-DNA-binding protein 1	yes
human	9606	IFI16	IFI16	cGLR/STING	Cytosolic nucleic-acid sensing	Q16666	reviewed	1	yes	yes	Gamma-interferon-inducible protein 16	yes
human	9606	CLEC7A	CLEC7A	C-type lectin	C-type lectin receptors	Q9BXN2	reviewed	1	yes	yes	C-type lectin domain family 7 member A	no
human	9606	CLEC4E	CLEC4E	C-type lectin	C-type lectin receptors	Q9ULY5	reviewed	1	yes	yes	C-type lectin domain family 4 member E	no
human	9606	CD209	CD209	C-type lectin	C-type lectin receptors	Q9NNX6	reviewed	1	yes	yes	CD209 antigen	no
human	9606	SYK	SYK	C-type lectin	C-type lectin receptors	P43405	reviewed	1	yes	yes	Tyrosine-protein kinase SYK	no
human	9606	CARD9	CARD9	C-type lectin	C-type lectin receptors	Q9H257	reviewed	1	yes	yes	Caspase recruitment domain-containing protein 9	no
human	9606	MBL2	MBL2	lectin complement	Complement and soluble PRRs	P11226	reviewed	1	yes	yes	Mannose-binding protein C	yes
human	9606	FCN2	FCN2	lectin complement	Complement and soluble PRRs	Q15485	reviewed	1	yes	yes	Ficolin-2	no
human	9606	MASP2	MASP2	lectin complement	Complement and soluble PRRs	O00187	reviewed	1	yes	yes	Mannan-binding lectin serine protease 2	no
human	9606	C3	C3	lectin complement	Complement and soluble PRRs	P01024	reviewed	1	yes	yes	Complement C3	no
human	9606	PGLYRP1	PGLYRP1	PGRP	Complement and soluble PRRs	O75594	reviewed	1	yes	yes	Peptidoglycan recognition protein 1	no
human	9606	PGLYRP2	PGLYRP2	PGRP	Complement and soluble PRRs	Q96PD5	reviewed	1	yes	yes	N-acetylmuramoyl-L-alanine amidase	no
human	9606	OAS1	OAS1	antiviral effector	Interferon effectors	P00973	reviewed	1	yes	yes	2'-5'-oligoadenylate synthase 1	no
human	9606	RNASEL	RNASEL	antiviral effector	Interferon effectors	Q05823	reviewed	1	yes	yes	2-5A-dependent ribonuclease	no
human	9606	EIF2AK2	EIF2AK2	antiviral effector	Interferon effectors	P19525	reviewed	1	yes	yes	Interferon-induced, double-stranded RNA-activated protein kinase	no
human	9606	MX1	MX1	antiviral effector	Interferon effectors	P20591	reviewed	1	yes	yes	Interferon-induced GTP-binding protein Mx1	no
human	9606	DEFB4A	DEFB4A	AMP	Antimicrobial effectors	O15263	reviewed	1	yes	yes	Defensin beta 4A	no
human	9606	CAMP	CAMP	AMP	Antimicrobial effectors	P49913	reviewed	1	yes	yes	Cathelicidin antimicrobial peptide	no
human	9606	LYZ	LYZ	AMP	Antimicrobial effectors	P61626	reviewed	1	yes	yes	Lysozyme C	no
mouse	10090	Tlr11	Tlr11	TLR	Toll-like receptor signaling	Q6R5P0	reviewed	1	yes	yes	Toll-like receptor 11	yes
mouse	10090	Tlr12	Tlr12	TLR	Toll-like receptor signaling	Q6QNU9	reviewed	1	yes	yes	Toll-like receptor 12	yes
mouse	10090	Tlr13	Tlr13	TLR	Toll-like receptor signaling	Q6R5N8	reviewed	1	yes	yes	Toll-like receptor 13	yes
mouse	10090	Tlr4	Tlr4	TLR	Toll-like receptor signaling	Q9QUK6	reviewed	1	yes	yes	Toll-like receptor 4	no
mouse	10090	Naip5	Naip5	NLR	NLR signaling and inflammasomes	Q9R016	reviewed	1	yes	yes	Baculoviral IAP repeat-containing protein 1e	no
mouse	10090	Nlrp1b	Nlrp1b	NLR	NLR signaling and inflammasomes	A1Z198	reviewed	5	yes	yes	NACHT, LRR and PYD domains-containing protein 1b allele 2	no
mouse	10090	Nlrc4	Nlrc4	NLR	NLR signaling and inflammasomes	Q3UP24	reviewed	1	yes	yes	NLR family CARD domain-containing protein 4	no
CHICK	9031	TLR15	TLR15	TLR	Toll-like receptor signaling	A0A8V0Z0H8	unreviewed	1	yes	yes	Toll-like receptor 15	yes
CHICK	9031	TLR21	TLR21	TLR	Toll-like receptor signaling	A0A8V0ZKW5	unreviewed	1	yes	yes	Toll like receptor 21	yes
CHICK	9031	TLR3	TLR3	TLR	Toll-like receptor signaling	A0A8V0YT51	unreviewed	9	yes	yes	Toll-like receptor 3	no
CHICK	9031	TLR4	TLR4	TLR	Toll-like receptor signaling	C4PCF3	unreviewed	7	yes	yes	Toll-like receptor 4	no
CHICK	9031	TLR7	TLR7	TLR	Toll-like receptor signaling	A0A1L4FML6	unreviewed	7	yes	yes	Toll like receptor 7	no
CHICK	9031	MYD88	MYD88	TIR adaptor	Toll-like receptor signaling	A5HNF6	reviewed	1	yes	yes	Myeloid differentiation primary response protein MyD88	no
CHICK	9031	IFIH1	IFIH1	RLR	Cytosolic nucleic-acid sensing	A0A1D5P5I0	unreviewed	3	yes	yes	RNA helicase	no
CHICK	9031	MAVS	MAVS	RLR	Cytosolic nucleic-acid sensing	A0A8V0YPL4	unreviewed	4	yes	yes	Mitochondrial antiviral signaling protein	no
CHICK	9031	STING1	STING1	cGLR/STING	Cytosolic nucleic-acid sensing	E1C7U0	reviewed	1	yes	yes	Stimulator of interferon genes protein	no
CHICK	9031	CGAS	CGAS	cGLR/STING	Cytosolic nucleic-acid sensing	A0A8V0X930	unreviewed	1	yes	yes	Cyclic GMP-AMP synthase	no
DANRE	7955	tlr3	tlr3	TLR	Toll-like receptor signaling	A0A8M1N4E3	unreviewed	2	yes	yes	Toll-like receptor 3	no
DANRE	7955	tlr4ba	tlr4ba	TLR	Toll-like receptor signaling	A0A8M3B7X7	unreviewed	3	yes	yes	Toll-like receptor 4	no
DANRE	7955	tlr5a	tlr5a	TLR	Toll-like receptor signaling	F8W4F1	unreviewed	1	yes	yes	Toll-like receptor 5	no
DANRE	7955	tlr5b	tlr5b	TLR	Toll-like receptor signaling	A0ACM8R384	unreviewed	3	yes	yes	Toll-like receptor 5b precursor	yes
DANRE	7955	tlr22	tlr22	TLR	Toll-like receptor signaling	A0A2R8RTN4	unreviewed	1	yes	yes	Toll-like receptor 22 precursor	yes
DANRE	7955	tlr21	tlr21	TLR	Toll-like receptor signaling	F1QMN8	unreviewed	1	yes	yes	Toll-like receptor 21 precursor	yes
DANRE	7955	tlr18	tlr18	TLR	Toll-like receptor signaling	A3KH14	unreviewed	7	yes	yes	Toll-like receptor 18 isoform X4	no
DANRE	7955	tlr19.1	tlr19.1	TLR	Toll-like receptor signaling	A0A8M1RKQ4	unreviewed	4	yes	yes	Toll-like receptor 12	no
DANRE	7955	tlr20.2	tlr20.2	TLR	Toll-like receptor signaling	F1QRG0	unreviewed	4	yes	yes	Toll-like receptor 20, tandem duplicate 2	no
DANRE	7955	myd88	myd88	TIR adaptor	Toll-like receptor signaling	Q5XJ85	reviewed	1	yes	yes	Myeloid differentiation primary response protein MyD88	no
DANRE	7955	ticam1	ticam1	TIR adaptor	Toll-like receptor signaling	A0A8M1N991	unreviewed	2	yes	yes	TIR domain-containing adapter molecule 1	no
DANRE	7955	irak4	irak4	TIR adaptor	Toll-like receptor signaling	A0AC58IUN4	unreviewed	3	yes	yes	Interleukin-1 receptor-associated kinase 4	no
DANRE	7955	traf6	traf6	TIR adaptor	Toll-like receptor signaling	Q6IWL4	reviewed	1	yes	yes	TNF receptor-associated factor 6	no
DANRE	7955	nod1	nod1	NLR	NLR signaling and inflammasomes	A0A8M1RMD1	unreviewed	2	yes	yes	Nucleotide-binding oligomerization domain-containing protein 1 isoform X1	no
DANRE	7955	nod2	nod2	NLR	NLR signaling and inflammasomes	A0A8M1P9S9	unreviewed	1	yes	yes	Nucleotide-binding oligomerization domain-containing protein 2	no
DANRE	7955	pycard	pycard	NLR	NLR signaling and inflammasomes	Q9I9N6	reviewed	1	yes	yes	Apoptosis-associated speck-like protein containing a CARD	no
DANRE	7955	caspa	caspa	NLR	NLR signaling and inflammasomes	Q9I9L7	reviewed	1	yes	yes	Caspase a	no
DANRE	7955	caspb	caspb	NLR	NLR signaling and inflammasomes	Q504J1	reviewed	1	yes	yes	Caspase b	no
DANRE	7955	rigi	rigi	RLR	Cytosolic nucleic-acid sensing	A0A8M1P6Y9	unreviewed	2	yes	yes	RNA helicase	no
DANRE	7955	mavs	mavs	RLR	Cytosolic nucleic-acid sensing	B8A4W7	unreviewed	3	yes	yes	Mitochondrial antiviral-signaling protein	no
DANRE	7955	sting1	sting1	cGLR/STING	Cytosolic nucleic-acid sensing	E7F4N7	reviewed	1	yes	yes	Stimulator of interferon genes protein	no
DANRE	7955	cgasa	cgasa	cGLR/STING	Cytosolic nucleic-acid sensing	F1QCP4	unreviewed	1	yes	yes	Cyclic GMP-AMP synthase	no
XENTR	8364	myd88	myd88	TIR adaptor	Toll-like receptor signaling	Q28DJ2	reviewed	1	yes	yes	Myeloid differentiation primary response protein MyD88	no
XENTR	8364	tlr5	tlr5	TIR adaptor	Toll-like receptor signaling	A0A803K1J2	unreviewed	1	yes	yes	Toll-like receptor 5	no
DROME	7227	PGRP-SA	PGRP-SA	Toll pathway recognition	Drosophila Toll pathway	Q9VYX7	reviewed	1	yes	yes	Peptidoglycan-recognition protein SA	no
DROME	7227	PGRP-SD	PGRP-SD	Toll pathway recognition	Drosophila Toll pathway	Q9VS97	reviewed	1	yes	yes	Peptidoglycan-recognition protein SD	no
DROME	7227	GNBP1	GNBP1	Toll pathway recognition	Drosophila Toll pathway	Q9NHB0	reviewed	1	yes	yes	Gram-negative bacteria-binding protein 1	no
DROME	7227	GNBP3	GNBP3	Toll pathway recognition	Drosophila Toll pathway	Q9NHA8	reviewed	1	yes	yes	Gram-negative bacteria-binding protein 3	no
DROME	7227	modSP	modSP	Toll pathway recognition	Drosophila Toll pathway	Q9VER6	reviewed	1	yes	yes	Modular serine protease	no
DROME	7227	Grass	Grass	Toll pathway recognition	Drosophila Toll pathway	Q9VB68	reviewed	1	yes	yes	Serine protease grass	no
DROME	7227	SPE	SPE	Toll pathway recognition	Drosophila Toll pathway	Q9VCJ8	reviewed	1	yes	yes	Spaetzle-processing enzyme	no
DROME	7227	psh	psh	Toll pathway recognition	Drosophila Toll pathway	Q9VWU1	reviewed	1	yes	yes	Serine protease persephone	no
DROME	7227	nec	nec	Toll pathway recognition	Drosophila Toll pathway	A1Z6V7	unreviewed	3	yes	yes	Necrotic	no
DROME	7227	spz	spz	Toll receptor	Drosophila Toll pathway	P48607	reviewed	1	yes	yes	Protein spaetzle	yes
DROME	7227	Tl	Tl	Toll receptor	Drosophila Toll pathway	P08953	reviewed	1	yes	yes	Protein toll	yes
DROME	7227	18w	18w	Toll receptor	Drosophila Toll pathway	A1ZBR2	unreviewed	4	yes	yes	18 wheeler	yes
DROME	7227	Toll-7	Toll-7	Toll receptor	Drosophila Toll pathway	Q7KIN0	reviewed	1	yes	yes	Toll-like receptor 7	yes
DROME	7227	Myd88	Myd88	TIR adaptor	Drosophila Toll pathway	A1Z7T8	unreviewed	2	yes	yes	Myd88, isoform A	yes
DROME	7227	tub	tub	TIR adaptor	Drosophila Toll pathway	P22812	reviewed	1	yes	yes	Protein Tube	yes
DROME	7227	pll	pll	TIR adaptor	Drosophila Toll pathway	Q05652	reviewed	1	yes	yes	Serine/threonine-protein kinase pelle	yes
DROME	7227	cact	cact	TIR adaptor	Drosophila Toll pathway	Q03017	reviewed	1	yes	yes	NF-kappa-B inhibitor cactus	yes
DROME	7227	dl	dl	TIR adaptor	Drosophila Toll pathway	P15330	reviewed	1	yes	yes	Embryonic polarity protein dorsal	yes
DROME	7227	Dif	Dif	TIR adaptor	Drosophila Toll pathway	P98149	reviewed	1	yes	yes	Dorsal-related immunity factor Dif	yes
DROME	7227	PGRP-LC	PGRP-LC	Imd pathway	Drosophila Imd pathway	Q9GNK5	reviewed	1	yes	yes	Peptidoglycan-recognition protein LC	no
DROME	7227	PGRP-LE	PGRP-LE	Imd pathway	Drosophila Imd pathway	Q9VXN9	reviewed	1	yes	yes	Peptidoglycan-recognition protein LE	no
DROME	7227	imd	imd	Imd pathway	Drosophila Imd pathway	Q7K4Z4	reviewed	1	yes	yes	Protein immune deficiency	no
DROME	7227	Fadd	Fadd	Imd pathway	Drosophila Imd pathway	Q9V3B4	reviewed	1	yes	yes	Fas-associated death domain protein	no
DROME	7227	Dredd	Dredd	Imd pathway	Drosophila Imd pathway	Q8IRY7	reviewed	1	yes	yes	Caspase-8	no
DROME	7227	Diap2	Diap2	Imd pathway	Drosophila Imd pathway	Q24307	reviewed	1	yes	yes	Death-associated inhibitor of apoptosis 2	no
DROME	7227	Tak1	Tak1	Imd pathway	Drosophila Imd pathway	Q9V3Q6	reviewed	1	yes	yes	Mitogen-activated protein kinase kinase kinase 7	no
DROME	7227	Tab2	Tab2	Imd pathway	Drosophila Imd pathway	A0A0B4KG87	unreviewed	5	yes	yes	TAK1-associated binding protein 2, isoform C	no
DROME	7227	IKKbeta	IKKbeta	Imd pathway	Drosophila Imd pathway	Q9VEZ5	reviewed	1	yes	yes	Inhibitor of nuclear factor kappa-B kinase subunit beta	no
DROME	7227	key	key	Imd pathway	Drosophila Imd pathway	Q9GYV5	reviewed	1	yes	yes	NF-kappa-B essential modulator	no
DROME	7227	Rel	Rel	Imd pathway	Drosophila Imd pathway	Q94527	reviewed	1	yes	yes	Nuclear factor NF-kappa-B p110 subunit	no
DROME	7227	cGlr1	cGlr1	cGLR/STING	Cytosolic nucleic-acid sensing	A1ZA55	reviewed	1	yes	yes	Cyclic GMP-AMP synthase-like receptor 1	no
DROME	7227	cGlr2	cGlr2	cGLR/STING	Cytosolic nucleic-acid sensing	A8DYP7	reviewed	1	yes	yes	Cyclic GMP-AMP synthase-like receptor 2	no
DROME	7227	Sting	Sting	cGLR/STING	Cytosolic nucleic-acid sensing	A0A0B4LFY9	reviewed	1	yes	yes	Stimulator of interferon genes protein homolog	no
DROME	7227	hop	hop	JAK/STAT	Drosophila JAK-STAT	Q24592	reviewed	1	yes	yes	Tyrosine-protein kinase hopscotch	no
DROME	7227	Stat92E	Stat92E	JAK/STAT	Drosophila JAK-STAT	Q24151	reviewed	1	yes	yes	Signal transducer and transcription activator	no
DROME	7227	upd3	upd3	JAK/STAT	Drosophila JAK-STAT	Q59E38	unreviewed	1	yes	yes	Unpaired 3	no
DROME	7227	TotA	TotA	JAK/STAT	Drosophila JAK-STAT	Q8IN44	reviewed	1	yes	yes	Protein Turandot A	no
DROME	7227	Drs	Drs	AMP	Antimicrobial effectors	P41964	reviewed	1	yes	yes	Drosomycin	no
DROME	7227	DptA	DptA	AMP	Antimicrobial effectors	P24492	reviewed	1	yes	yes	Diptericin A	no
DROME	7227	Mtk	Mtk	AMP	Antimicrobial effectors	Q24395	reviewed	1	yes	yes	Metchnikowin	no
DROME	7227	AttA	AttA	AMP	Antimicrobial effectors	P45884	reviewed	1	yes	yes	Attacin-A	no
DROME	7227	CecA1	CecA1	AMP	Antimicrobial effectors	C0HKQ7	reviewed	1	yes	yes	Cecropin-A1	no
DROME	7227	Def	Def	AMP	Antimicrobial effectors	P36192	reviewed	1	yes	yes	Defensin	no
DROME	7227	Tep1	Tep1	TEP	Complement and soluble PRRs	Q7KT66	unreviewed	2	yes	yes	TEP1-F	no
DROME	7227	Tep2	Tep2	TEP	Complement and soluble PRRs	Q8IPH5	unreviewed	7	yes	yes	CD109 antigen	no
ANOGA	7165	TEP1	TEP1	TEP	Complement and soluble PRRs	Q9GYW4	reviewed	3	yes	yes	Thioester-containing protein 1 allele S1	yes
ANOGA	7165	LRIM1	LRIM1	TEP	Complement and soluble PRRs	A7XBG8	unreviewed	16	yes	no	LRIM1	no
ANOGA	7165	APL1C	APL1C	TEP	Complement and soluble PRRs	L7T8J3	unreviewed	3	yes	no	APL1C	no
ANOGA	7165	REL2	REL2	TEP	Complement and soluble PRRs	B2FXG9	unreviewed	6	yes	no	REL2 protein	no
worm	6239	tol-1	tol-1	TIR adaptor	C. elegans p38 PMK-1 pathway	Q9N5Z3	unreviewed	1	yes	yes	TIR domain-containing protein	yes
worm	6239	tir-1	tir-1	TIR adaptor	C. elegans p38 PMK-1 pathway	Q86DA5	reviewed	1	yes	yes	NAD(+) hydrolase tir-1	yes
worm	6239	nsy-1	nsy-1	TIR adaptor	C. elegans p38 PMK-1 pathway	Q21029	reviewed	1	yes	yes	Mitogen-activated protein kinase kinase kinase nsy-1	yes
worm	6239	sek-1	sek-1	TIR adaptor	C. elegans p38 PMK-1 pathway	G5EDF7	reviewed	1	yes	yes	Dual specificity mitogen-activated protein kinase kinase sek-1	yes
worm	6239	pmk-1	pmk-1	TIR adaptor	C. elegans p38 PMK-1 pathway	Q17446	reviewed	1	yes	yes	Mitogen-activated protein kinase pmk-1	yes
worm	6239	atf-7	atf-7	TIR adaptor	C. elegans p38 PMK-1 pathway	Q86MD3	reviewed	1	yes	yes	Transcription factor atf-7	yes
worm	6239	dkf-2	dkf-2	TIR adaptor	C. elegans p38 PMK-1 pathway	O45818	reviewed	1	yes	yes	Serine/threonine-protein kinase dkf-2	no
worm	6239	nipi-3	nipi-3	TIR adaptor	C. elegans p38 PMK-1 pathway	G5EED4	reviewed	1	yes	yes	Protein nipi-3	yes
worm	6239	zip-2	zip-2	surveillance	C. elegans p38 PMK-1 pathway	Q21148	reviewed	1	yes	yes	Transcription factor zip-2	yes
worm	6239	fshr-1	fshr-1	surveillance	C. elegans p38 PMK-1 pathway	L8EC40	unreviewed	2	yes	yes	G-protein coupled receptors family 1 profile domain-containing protein	yes
worm	6239	dbl-1	dbl-1	TGF-beta	C. elegans epidermal/TGF-beta immunity	G5EEL5	reviewed	1	yes	yes	Protein dbl-1	yes
worm	6239	sma-3	sma-3	TGF-beta	C. elegans epidermal/TGF-beta immunity	P45896	reviewed	1	yes	yes	Dwarfin sma-3	no
worm	6239	sta-2	sta-2	TGF-beta	C. elegans epidermal/TGF-beta immunity	Q20977	reviewed	1	yes	yes	Signal transducer and activator of transcription b	yes
worm	6239	nlp-29	nlp-29	TGF-beta	C. elegans epidermal/TGF-beta immunity	O44664	reviewed	1	yes	yes	Neuropeptide-like protein 29	yes
worm	6239	clec-60	clec-60	effector	Antimicrobial effectors	Q23564	unreviewed	1	yes	yes	VWFA domain-containing protein	yes
worm	6239	lys-7	lys-7	effector	Antimicrobial effectors	O16202	reviewed	1	yes	yes	Lysozyme-like protein 7	yes
worm	6239	spp-1	spp-1	effector	Antimicrobial effectors	Q22291	unreviewed	1	yes	yes	Saposin B-type domain-containing protein	no
worm	6239	drh-1	drh-1	RLR	Cytosolic nucleic-acid sensing	G5EDI8	unreviewed	2	yes	yes	RNA helicase	no
NEMVE	45351	A7SLZ2	STING	cGLR/STING	Cytosolic nucleic-acid sensing	A7SLZ2	reviewed	1	yes	yes	Stimulator of interferon genes protein	no
NEMVE	45351	A7SFB5	cGAS	cGLR/STING	Cytosolic nucleic-acid sensing	A7SFB5	reviewed	1	yes	yes	Cyclic GMP-AMP synthase	no
NEMVE	45351	A7RHZ4	MyD88	TIR adaptor	Toll-like receptor signaling	A7RHZ4	unreviewed	1	yes	yes	Myeloid differentiation primary response protein MyD88	yes
NEMVE	45351	A7UNT2	NF-kappaB	NF-kappaB/Rel	NF-kappaB / IRF output	A7UNT2	unreviewed	1	yes	no	NF-kappa-B	no
TACTR	6853	P28175	factor C	LPS-triggered serine protease cascade	Horseshoe crab coagulation cascade	P28175	reviewed	1	yes	no	Clotting factor C	no
TACTR	6853	Q27081	factor B	LPS-triggered serine protease cascade	Horseshoe crab coagulation cascade	Q27081	reviewed	1	yes	no	Clotting factor B	no
TACTR	6853	Q27082	factor G alpha	beta-glucan-triggered serine protease cascade	Horseshoe crab coagulation cascade	Q27082	reviewed	1	yes	no	Clotting factor G alpha subunit	no
TACTR	6853	Q27083	factor G beta	beta-glucan-triggered serine protease cascade	Horseshoe crab coagulation cascade	Q27083	reviewed	1	yes	no	Clotting factor G beta subunit	no
TACTR	6853	P21902	proclotting enzyme	LPS-triggered serine protease cascade	Horseshoe crab coagulation cascade	P21902	reviewed	1	yes	no	Proclotting enzyme	no
TACTR	6853	P02681	coagulogen	clotting substrate	Horseshoe crab coagulation cascade	P02681	reviewed	1	yes	no	Coagulogen	no