# Pre-filled IRD node assessments awaiting a verdict. Generated by # seed_ird_assessments.py; regenerate rather than hand-edit. To adjudicate one, copy # its node_assessment into the family review and add assessment + assessment_reason. seeds: - family: PANTHER:PTHR10210 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 133 proteins_with_low_throughput_positive: 7 conflicting_experimental_annotations: - protein: UniProtKB:P09330 symbol: Prps2 organism: Rattus norvegicus annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:2546925 assigned_by: RGD - protein: UniProtKB:Q63468 symbol: Prpsap1 organism: Rattus norvegicus annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:2546925 assigned_by: RGD - protein: UniProtKB:O08618 symbol: Prpsap2 organism: Rattus norvegicus annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:2546925 assigned_by: RGD - protein: UniProtKB:P38620 symbol: PRS2 organism: Saccharomyces cerevisiae annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:15280369 assigned_by: SGD - protein: UniProtKB:P38689 symbol: PRS3 organism: Saccharomyces cerevisiae annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:15280369 assigned_by: SGD - protein: UniProtKB:P38063 symbol: PRS4 organism: Saccharomyces cerevisiae annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:15280369 assigned_by: SGD - protein: UniProtKB:Q12265 symbol: PRS5 organism: Saccharomyces cerevisiae annotation: part_of GO:0002189 ribose phosphate diphosphokinase complex evidence: IDA reference: PMID:15280369 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000025038 asserted_term: id: GO:0002189 label: ribose phosphate diphosphokinase complex evidence: IRD negated: true seeds: - id: PANTHER:PTN000025022 label: PTN000025022 (ancestral IBD node; IRD source) paint_snapshot: '20240516' node_taxon: id: NCBITaxon:33154 label: Opisthokonta - family: PANTHER:PTHR11588 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 134 proteins_with_low_throughput_positive: 7 conflicting_experimental_annotations: - protein: UniProtKB:P38557 symbol: TUBG1 organism: Arabidopsis thaliana annotation: located_in GO:0005874 microtubule evidence: IDA reference: PMID:16603653 assigned_by: TAIR - protein: UniProtKB:P38558 symbol: TUBG2 organism: Arabidopsis thaliana annotation: located_in GO:0005874 microtubule evidence: IDA reference: PMID:16603653 assigned_by: TAIR - protein: UniProtKB:P23257 symbol: gammaTub23C organism: Drosophila melanogaster annotation: located_in GO:0005874 microtubule evidence: IDA reference: PMID:18798690 assigned_by: FlyBase - protein: UniProtKB:P23258 symbol: TUBG1 organism: Homo sapiens annotation: located_in GO:0005827 polar microtubule evidence: IDA reference: PMID:9566969 assigned_by: UniProt - protein: UniProtKB:P23258 symbol: TUBG1 organism: Homo sapiens annotation: located_in GO:1990498 mitotic spindle microtubule evidence: IDA reference: PMID:30723163 assigned_by: UniProt - protein: UniProtKB:Q9NRH3 symbol: TUBG2 organism: Homo sapiens annotation: located_in GO:0005874 microtubule evidence: IDA reference: PMID:21525035 assigned_by: UniProt - protein: UniProtKB:P83887 symbol: Tubg1 organism: Mus musculus annotation: located_in GO:0005876 spindle microtubule evidence: IDA reference: PMID:14667810 assigned_by: MGI - protein: UniProtKB:P83887 symbol: Tubg1 organism: Mus musculus annotation: located_in GO:0005881 cytoplasmic microtubule evidence: IDA reference: PMID:14667810 assigned_by: MGI - protein: UniProtKB:P83887 symbol: Tubg1 organism: Mus musculus annotation: located_in GO:0005881 cytoplasmic microtubule evidence: IDA reference: PMID:18347012 assigned_by: MGI - protein: UniProtKB:Q8VCK3 symbol: Tubg2 organism: Mus musculus annotation: located_in GO:0005876 spindle microtubule evidence: IDA reference: PMID:14667810 assigned_by: MGI - protein: UniProtKB:Q8VCK3 symbol: Tubg2 organism: Mus musculus annotation: located_in GO:0005881 cytoplasmic microtubule evidence: IDA reference: PMID:14667810 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000172659 asserted_term: id: GO:0005874 label: microtubule evidence: IRD negated: true seeds: - id: PANTHER:PTN000172598 label: PTN000172598 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11309 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 156 proteins_with_low_throughput_positive: 6 conflicting_experimental_annotations: - protein: UniProtKB:O19116 symbol: SFRP1 organism: Bos taurus annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:18156211 assigned_by: MGI - protein: UniProtKB:O19116 symbol: SFRP1 organism: Bos taurus annotation: located_in GO:0005886 plasma membrane evidence: IMP reference: PMID:18156211 assigned_by: BHF-UCL - protein: UniProtKB:G5EDV1 symbol: lin-17 organism: Caenorhabditis elegans annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:16631156 assigned_by: WB - protein: UniProtKB:G5EDV1 symbol: lin-17 organism: Caenorhabditis elegans annotation: located_in GO:0032589 neuron projection membrane evidence: IDA reference: PMID:19259273 assigned_by: WB - protein: UniProtKB:O00144 symbol: FZD9 organism: Homo sapiens annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:19038973 assigned_by: UniProt - protein: UniProtKB:Q8BKG4 symbol: Fzd10 organism: Mus musculus annotation: located_in GO:0005886 plasma membrane evidence: EXP reference: PMID:15923619 assigned_by: UniProt - protein: UniProtKB:Q9R216 symbol: Fzd9 organism: Mus musculus annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:10198163 assigned_by: MGI - protein: UniProtKB:Q9R216 symbol: Fzd9 organism: Mus musculus annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:24860427 assigned_by: UniProt - protein: UniProtKB:Q9R216 symbol: Fzd9 organism: Mus musculus annotation: located_in GO:0031527 filopodium membrane evidence: IDA reference: PMID:10198163 assigned_by: MGI - protein: UniProtKB:Q8K4C8 symbol: Fzd9 organism: Rattus norvegicus annotation: located_in GO:0005886 plasma membrane evidence: EXP reference: PMID:12138115 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002259328 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000139394 label: PTN000139394 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:6072 label: Eumetazoa - family: PANTHER:PTHR23086 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 77 proteins_with_low_throughput_positive: 5 conflicting_experimental_annotations: - protein: UniProtKB:B3DJ34 symbol: LOC560360 organism: Danio rerio annotation: enables GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IMP reference: PMID:23542014 assigned_by: ZFIN - protein: UniProtKB:P48426 symbol: PIP4K2A organism: Homo sapiens annotation: enables GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IDA reference: PMID:26774281 assigned_by: UniProt - protein: UniProtKB:P78356 symbol: PIP4K2B organism: Homo sapiens annotation: enables GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IDA reference: PMID:26774281 assigned_by: UniProt - protein: UniProtKB:P78356 symbol: PIP4K2B organism: Homo sapiens annotation: enables GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IDA reference: PMID:9038203 assigned_by: MGI - protein: UniProtKB:Q8TBX8 symbol: PIP4K2C organism: Homo sapiens annotation: enables GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IDA reference: PMID:26774281 assigned_by: UniProt - protein: UniProtKB:O88370 symbol: Pip4k2c organism: Rattus norvegicus annotation: enables GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IDA reference: PMID:9685379 assigned_by: RGD node_assessment: node_id: PANTHER:PTN001132453 asserted_term: id: GO:0016308 label: 1-phosphatidylinositol-4-phosphate 5-kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000557041 label: PTN000557041 (ancestral IBD node; IRD source) paint_snapshot: '20260828' - family: PANTHER:PTHR10625 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 42 proteins_with_low_throughput_positive: 4 conflicting_experimental_annotations: - protein: UniProtKB:M9PJN5 symbol: HDAC6 organism: Drosophila melanogaster annotation: enables GO:0004407 histone deacetylase activity evidence: IDA reference: PMID:16137856 assigned_by: FlyBase - protein: UniProtKB:M9PJN5 symbol: HDAC6 organism: Drosophila melanogaster annotation: enables GO:0004407 histone deacetylase activity evidence: IMP reference: PMID:25578876 assigned_by: FlyBase - protein: UniProtKB:M9PJN5 symbol: HDAC6 organism: Drosophila melanogaster annotation: enables GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism evidence: IDA reference: PMID:11281647 assigned_by: FlyBase - protein: UniProtKB:M9PJN5 symbol: HDAC6 organism: Drosophila melanogaster annotation: enables GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism evidence: IDA reference: PMID:11281647 assigned_by: FlyBase - protein: UniProtKB:M9PJN5 symbol: HDAC6 organism: Drosophila melanogaster annotation: enables GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism evidence: IDA reference: PMID:11281647 assigned_by: FlyBase - protein: UniProtKB:M9PJN5 symbol: HDAC6 organism: Drosophila melanogaster annotation: enables GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism evidence: IDA reference: PMID:11281647 assigned_by: FlyBase - protein: UniProtKB:Q969S8 symbol: HDAC10 organism: Homo sapiens annotation: enables GO:0004407 histone deacetylase activity evidence: IDA reference: PMID:11861901 assigned_by: UniProt - protein: UniProtKB:Q9UBN7 symbol: HDAC6 organism: Homo sapiens annotation: enables GO:0004407 histone deacetylase activity evidence: IDA reference: PMID:10220385 assigned_by: MGI - protein: UniProtKB:Q9Z2V5 symbol: Hdac6 organism: Mus musculus annotation: enables GO:0004407 histone deacetylase activity evidence: IDA reference: PMID:11689694 assigned_by: MGI - protein: UniProtKB:Q9Z2V5 symbol: Hdac6 organism: Mus musculus annotation: enables GO:0004407 histone deacetylase activity evidence: IMP reference: PMID:24882211 assigned_by: CACAO - protein: UniProtKB:Q9Z2V5 symbol: Hdac6 organism: Mus musculus annotation: enables GO:0004407 histone deacetylase activity evidence: IDA reference: PMID:9891014 assigned_by: MGI node_assessment: node_id: PANTHER:PTN008492157 asserted_term: id: GO:0004407 label: histone deacetylase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN008143312 label: PTN008143312 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR11309 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 156 proteins_with_low_throughput_positive: 4 conflicting_experimental_annotations: - protein: UniProtKB:Q9W6E3 symbol: fk48e04 organism: Danio rerio annotation: enables GO:0042813 Wnt receptor activity evidence: IMP reference: PMID:12676325 assigned_by: ZFIN - protein: UniProtKB:Q9ULW2 symbol: FZD10 organism: Homo sapiens annotation: enables GO:0042813 Wnt receptor activity evidence: IDA reference: PMID:28733458 assigned_by: WB - protein: UniProtKB:Q9R216 symbol: Fzd9 organism: Mus musculus annotation: enables GO:0042813 Wnt receptor activity evidence: IDA reference: PMID:24860427 assigned_by: UniProt - protein: UniProtKB:Q8K4C8 symbol: Fzd9 organism: Rattus norvegicus annotation: enables GO:0042813 Wnt receptor activity evidence: IDA reference: PMID:12138115 assigned_by: RGD node_assessment: node_id: PANTHER:PTN002259328 asserted_term: id: GO:0042813 label: Wnt receptor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000139394 label: PTN000139394 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:6072 label: Eumetazoa - family: PANTHER:PTHR23359 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 262 proteins_with_low_throughput_positive: 4 conflicting_experimental_annotations: - protein: UniProtKB:Q9VBI2 symbol: Cmpk organism: Drosophila melanogaster annotation: enables GO:0004017 AMP kinase activity evidence: IDA reference: PMID:14592433 assigned_by: FlyBase - protein: UniProtKB:Q5TCS8 symbol: AK9 organism: Homo sapiens annotation: enables GO:0004017 AMP kinase activity evidence: EXP reference: PMID:23416111 assigned_by: UniProt - protein: UniProtKB:P15700 symbol: URA6 organism: Saccharomyces cerevisiae annotation: enables GO:0004017 AMP kinase activity evidence: IDA reference: PMID:1333436 assigned_by: SGD - protein: UniProtKB:P15700 symbol: URA6 organism: Saccharomyces cerevisiae annotation: enables GO:0004017 AMP kinase activity evidence: IGI reference: PMID:1333436 assigned_by: SGD - protein: UniProtKB:Q38EC4 symbol: Tb09.211.0350 organism: Trypanosoma brucei annotation: enables GO:0004017 AMP kinase activity evidence: IDA reference: PMID:15657034 assigned_by: GeneDB node_assessment: node_id: PANTHER:PTN000599579 asserted_term: id: GO:0004017 label: AMP kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000599576 label: PTN000599576 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR24056 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 40 proteins_with_low_throughput_positive: 4 conflicting_experimental_annotations: - protein: UniProtKB:B9X2H6 symbol: Cdkl5 organism: Danio rerio annotation: enables GO:0004693 cyclin-dependent protein serine/threonine kinase activity evidence: IDA reference: PMID:26927518 assigned_by: ZFIN - protein: UniProtKB:O76039 symbol: CDKL5 organism: Homo sapiens annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IDA reference: PMID:30266825 assigned_by: UniProt - protein: UniProtKB:O76039 symbol: CDKL5 organism: Homo sapiens annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IDA reference: PMID:34605059 assigned_by: UniProt - protein: UniProtKB:Q3UTQ8 symbol: Cdkl5 organism: Mus musculus annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IDA reference: PMID:22922712 assigned_by: UniProt - protein: UniProtKB:Q3UTQ8 symbol: Cdkl5 organism: Mus musculus annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IDA reference: PMID:30266824 assigned_by: UniProt - protein: UniProtKB:Q12222 symbol: YGK3 organism: Saccharomyces cerevisiae annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IMP reference: PMID:10958669 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000756102 asserted_term: id: GO:0004674 label: protein serine/threonine kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000623091 label: PTN000623091 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR10638 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 21 proteins_with_low_throughput_positive: 3 conflicting_experimental_annotations: - protein: UniProtKB:Q16853 symbol: AOC3 organism: Homo sapiens annotation: enables GO:0008131 primary methylamine oxidase activity evidence: IDA reference: PMID:23474851 assigned_by: CACAO - protein: UniProtKB:Q16853 symbol: AOC3 organism: Homo sapiens annotation: enables GO:0008131 primary methylamine oxidase activity evidence: IDA reference: PMID:9653080 assigned_by: UniProt - protein: UniProtKB:O70423 symbol: Aoc3 organism: Mus musculus annotation: enables GO:0008131 primary methylamine oxidase activity evidence: IDA reference: PMID:14968297 assigned_by: MGI - protein: UniProtKB:O08590 symbol: Aoc3 organism: Rattus norvegicus annotation: enables GO:0008131 primary methylamine oxidase activity evidence: IDA reference: PMID:17393059 assigned_by: RGD node_assessment: node_id: PANTHER:PTN000067358 asserted_term: id: GO:0008131 label: primary methylamine oxidase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000067313 label: PTN000067313 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:9347 label: Eutheria - family: PANTHER:PTHR24056 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 60 proteins_with_low_throughput_positive: 3 conflicting_experimental_annotations: - protein: UniProtKB:Q9VT57 symbol: Cdk8 organism: Drosophila melanogaster annotation: part_of GO:0016592 mediator complex evidence: IDA reference: PMID:12556495 assigned_by: FlyBase - protein: UniProtKB:Q9VT57 symbol: Cdk8 organism: Drosophila melanogaster annotation: part_of GO:0016592 mediator complex evidence: IPI reference: PMID:17290221 assigned_by: FlyBase - protein: UniProtKB:P49336 symbol: CDK8 organism: Homo sapiens annotation: part_of GO:0016592 mediator complex evidence: IDA reference: PMID:14638676 assigned_by: MGI - protein: UniProtKB:P49336 symbol: CDK8 organism: Homo sapiens annotation: part_of GO:0016592 mediator complex evidence: IMP reference: PMID:30905399 assigned_by: UniProt - protein: UniProtKB:Q8R3L8 symbol: Cdk8 organism: Mus musculus annotation: part_of GO:0016592 mediator complex evidence: IDA reference: PMID:15340084 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000623095 asserted_term: id: GO:0016592 label: mediator complex evidence: IRD negated: true seeds: - id: PANTHER:PTN000623092 label: PTN000623092 (ancestral IBD node; IRD source) paint_snapshot: '20230512' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR10057 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 16 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:P50637 symbol: Tspo organism: Mus musculus annotation: is_active_in GO:0005741 mitochondrial outer membrane evidence: IDA reference: PMID:19552401 assigned_by: MGI - protein: UniProtKB:P16257 symbol: Tspo organism: Rattus norvegicus annotation: located_in GO:0005741 mitochondrial outer membrane evidence: IDA reference: PMID:19863077 assigned_by: RGD node_assessment: node_id: PANTHER:PTN001600146 asserted_term: id: GO:0005741 label: mitochondrial outer membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000006566 label: PTN000006566 (ancestral IBD node; IRD source) paint_snapshot: '20251218' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR10625 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 42 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q969S8 symbol: HDAC10 organism: Homo sapiens annotation: part_of GO:0000118 histone deacetylase complex evidence: IDA reference: PMID:11861901 assigned_by: UniProt - protein: UniProtKB:Q9UBN7 symbol: HDAC6 organism: Homo sapiens annotation: part_of GO:0000118 histone deacetylase complex evidence: IDA reference: PMID:11948178 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008492157 asserted_term: id: GO:0000118 label: histone deacetylase complex evidence: IRD negated: true seeds: - id: PANTHER:PTN000065904 label: PTN000065904 (ancestral IBD node; IRD source) paint_snapshot: '20250120' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR10694 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 45 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:O94953 symbol: KDM4B organism: Homo sapiens annotation: enables GO:0051864 histone H3K36 demethylase activity evidence: IDA reference: PMID:21914792 assigned_by: UniProt - protein: UniProtKB:Q91VY5 symbol: Kdm4b organism: Mus musculus annotation: enables GO:0051864 histone H3K36 demethylase activity evidence: IDA reference: PMID:16738407 assigned_by: MGI - protein: UniProtKB:Q91VY5 symbol: Kdm4b organism: Mus musculus annotation: enables GO:0051864 histone H3K36 demethylase activity evidence: IMP reference: PMID:16738407 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000075209 asserted_term: id: GO:0051864 label: histone H3K36 demethylase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000075207 label: PTN000075207 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR11207 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 96 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:A0A1D8PM62 symbol: DCR1 organism: Candida albicans annotation: involved_in GO:0030422 siRNA processing evidence: IDA reference: PMID:22173636 assigned_by: CGD - protein: UniProtKB:A0A1D8PM62 symbol: DCR1 organism: Candida albicans annotation: involved_in GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing evidence: IMP reference: PMID:38625945 assigned_by: CGD - protein: UniProtKB:P22192 symbol: pac1 organism: Schizosaccharomyces pombe annotation: involved_in GO:0000956 nuclear-transcribed mRNA catabolic process evidence: IMP reference: PMID:34352089 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN000129456 asserted_term: id: GO:0010468 label: regulation of gene expression evidence: IRD negated: true seeds: - id: PANTHER:PTN000129453 label: PTN000129453 (ancestral IBD node; IRD source) paint_snapshot: '20240729' node_taxon: id: NCBITaxon:33154 label: Opisthokonta - family: PANTHER:PTHR11405 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 13 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q7SH52 symbol: arg-3 organism: Neurospora crassa annotation: enables GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: EXP reference: PMID:6243618 assigned_by: UniProt - protein: UniProtKB:P03965 symbol: CPA2 organism: Saccharomyces cerevisiae annotation: contributes_to GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: IMP reference: PMID:6358221 assigned_by: SGD - protein: UniProtKB:P03965 symbol: CPA2 organism: Saccharomyces cerevisiae annotation: contributes_to GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: IDA reference: PMID:8626695 assigned_by: SGD - protein: UniProtKB:P03965 symbol: CPA2 organism: Saccharomyces cerevisiae annotation: enables GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: EXP reference: PMID:206535 assigned_by: UniProt - protein: UniProtKB:P03965 symbol: CPA2 organism: Saccharomyces cerevisiae annotation: enables GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: EXP reference: PMID:206652 assigned_by: UniProt - protein: UniProtKB:P03965 symbol: CPA2 organism: Saccharomyces cerevisiae annotation: enables GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: EXP reference: PMID:5856369 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000892150 asserted_term: id: GO:0004088 label: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000150223 label: PTN000150223 (ancestral IBD node; IRD source) paint_snapshot: '20181129' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR11588 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_SUPPORTED clade_size: 134 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:P18695 symbol: mipA organism: Emericella nidulans annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IMP reference: PMID:11452008 assigned_by: AspGD - protein: UniProtKB:P18695 symbol: mipA organism: Emericella nidulans annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IMP reference: PMID:2194669 assigned_by: AspGD - protein: UniProtKB:P53378 symbol: TUB4 organism: Saccharomyces cerevisiae annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IMP reference: PMID:8557744 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000172659 asserted_term: id: GO:0005200 label: structural constituent of cytoskeleton evidence: IRD negated: true seeds: - id: PANTHER:PTN000172598 label: PTN000172598 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11671 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 45 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:P39942 symbol: ATP6V1D organism: Bos taurus annotation: part_of GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain evidence: IDA reference: PMID:32764564 assigned_by: UniProt - protein: UniProtKB:Q9Y5K8 symbol: ATP6V1D organism: Homo sapiens annotation: is_active_in GO:0005765 lysosomal membrane evidence: IDA reference: PMID:22053050 assigned_by: UniProt - protein: UniProtKB:Q9Y5K8 symbol: ATP6V1D organism: Homo sapiens annotation: part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex evidence: IDA reference: PMID:22053050 assigned_by: UniProt - protein: UniProtKB:Q9Y5K8 symbol: ATP6V1D organism: Homo sapiens annotation: located_in GO:0005765 lysosomal membrane evidence: HDA reference: PMID:17897319 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000912638 asserted_term: id: GO:0005774 label: vacuolar membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000186829 label: PTN000186829 (ancestral IBD node; IRD source) paint_snapshot: '20260528' - family: PANTHER:PTHR12247 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 33 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q1RNF8 symbol: Samd11 organism: Mus musculus annotation: part_of GO:0035102 PRC1 complex evidence: IDA reference: PMID:33603070 assigned_by: UniProt - protein: UniProtKB:Q8C8Y5 symbol: Samd7 organism: Mus musculus annotation: part_of GO:0035102 PRC1 complex evidence: IDA reference: PMID:28900001 assigned_by: UniProt - protein: UniProtKB:Q8C8Y5 symbol: Samd7 organism: Mus musculus annotation: part_of GO:0035102 PRC1 complex evidence: IDA reference: PMID:33603070 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002640813 asserted_term: id: GO:0035102 label: PRC1 complex evidence: IRD negated: true seeds: - id: PANTHER:PTN001745158 label: PTN001745158 (ancestral IBD node; IRD source) paint_snapshot: '20240205' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR12369 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 54 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q8IZ52 symbol: CHPF organism: Homo sapiens annotation: enables GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity evidence: IDA reference: PMID:12761225 assigned_by: FlyBase - protein: UniProtKB:Q6IQX7 symbol: Chpf organism: Mus musculus annotation: enables GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity evidence: IGI reference: PMID:17253960 assigned_by: MGI - protein: UniProtKB:Q6IQX7 symbol: Chpf organism: Mus musculus annotation: enables GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity evidence: IGI reference: PMID:22952769 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000961885 asserted_term: id: GO:0008376 label: acetylgalactosaminyltransferase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000961849 label: PTN000961849 (ancestral IBD node; IRD source) paint_snapshot: '20260603' node_taxon: id: NCBITaxon:6072 label: Eumetazoa - family: PANTHER:PTHR18966 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 7 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q9V4A0 symbol: DmelCG11155 organism: Drosophila melanogaster annotation: involved_in GO:0035249 synaptic transmission, glutamatergic evidence: IMP reference: PMID:38569548 assigned_by: FlyBase - protein: UniProtKB:Q0KIF2 symbol: Ekar organism: Drosophila melanogaster annotation: involved_in GO:0035249 synaptic transmission, glutamatergic evidence: IGI reference: PMID:25831426 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN001826347 asserted_term: id: GO:0035249 label: synaptic transmission, glutamatergic evidence: IRD negated: true seeds: - id: PANTHER:PTN001826301 label: PTN001826301 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:6656 label: Arthropoda - family: PANTHER:PTHR19139 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q13520 symbol: AQP6 organism: Homo sapiens annotation: involved_in GO:0003097 renal water transport evidence: IDA reference: PMID:8812490 assigned_by: UniProt - protein: UniProtKB:Q13520 symbol: AQP6 organism: Homo sapiens annotation: enables GO:0015250 water channel activity evidence: IDA reference: PMID:8812490 assigned_by: UniProt - protein: UniProtKB:Q9WTY0 symbol: Aqp6 organism: Rattus norvegicus annotation: enables GO:0015250 water channel activity evidence: IDA reference: PMID:10647010 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN001452348 asserted_term: id: GO:0006833 label: water transport evidence: IRD negated: true seeds: - id: PANTHER:PTN007668488 label: PTN007668488 (ancestral IBD node; IRD source) paint_snapshot: '20250903' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR19139 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q13520 symbol: AQP6 organism: Homo sapiens annotation: enables GO:0015250 water channel activity evidence: IDA reference: PMID:8812490 assigned_by: UniProt - protein: UniProtKB:Q9WTY0 symbol: Aqp6 organism: Rattus norvegicus annotation: enables GO:0015250 water channel activity evidence: IDA reference: PMID:10647010 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN001452348 asserted_term: id: GO:0015250 label: water channel activity evidence: IRD negated: true seeds: - id: PANTHER:PTN007668488 label: PTN007668488 (ancestral IBD node; IRD source) paint_snapshot: '20250903' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR19878 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 16 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q8NAA4 symbol: ATG16L2 organism: Homo sapiens annotation: part_of GO:0034274 Atg12-Atg5-Atg16 complex evidence: IPI reference: PMID:23202584 assigned_by: ComplexPortal - protein: UniProtKB:Q6KAU8 symbol: Atg16l2 organism: Mus musculus annotation: part_of GO:0034274 Atg12-Atg5-Atg16 complex evidence: IDA reference: PMID:12665549 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN002716574 asserted_term: id: GO:0034274 label: Atg12-Atg5-Atg16 complex evidence: IRD negated: true seeds: - id: PANTHER:PTN000459085 label: PTN000459085 (ancestral IBD node; IRD source) paint_snapshot: '20240118' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR24068 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_SUPPORTED clade_size: 219 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q9CZY3 symbol: Ube2v1 organism: Mus musculus annotation: contributes_to GO:0061631 ubiquitin conjugating enzyme activity evidence: IGI reference: PMID:14406273 assigned_by: MGI - protein: UniProtKB:Q9CZY3 symbol: Ube2v1 organism: Mus musculus annotation: contributes_to GO:0061631 ubiquitin conjugating enzyme activity evidence: IDA reference: PMID:22797923 assigned_by: MGI - protein: UniProtKB:O74983 symbol: mms2 organism: Schizosaccharomyces pombe annotation: enables GO:0061631 ubiquitin conjugating enzyme activity evidence: IDA reference: PMID:16641370 assigned_by: PomBase - protein: UniProtKB:O74983 symbol: mms2 organism: Schizosaccharomyces pombe annotation: enables GO:0061631 ubiquitin conjugating enzyme activity evidence: EXP reference: PMID:35011726 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN000629507 asserted_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002514495 label: PTN002514495 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR24103 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 12 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q8WV44 symbol: TRIM41 organism: Homo sapiens annotation: located_in GO:0005737 cytoplasm evidence: EXP reference: PMID:29899090 assigned_by: UniProt - protein: UniProtKB:Q8WV44 symbol: TRIM41 organism: Homo sapiens annotation: located_in GO:0005737 cytoplasm evidence: EXP reference: PMID:31979016 assigned_by: UniProt - protein: UniProtKB:Q8WV44 symbol: TRIM41 organism: Homo sapiens annotation: located_in GO:0005829 cytosol evidence: IDA reference: GO_REF:0000052 assigned_by: HPA - protein: UniProtKB:Q5NCC3 symbol: Trim41 organism: Mus musculus annotation: located_in GO:0005737 cytoplasm evidence: EXP reference: PMID:33640899 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000715044 asserted_term: id: GO:0005737 label: cytoplasm evidence: IRD negated: true seeds: - id: PANTHER:PTN007774218 label: PTN007774218 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:32525 label: Theria - family: PANTHER:PTHR24115 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 3 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:O14343 symbol: klp5 organism: Schizosaccharomyces pombe annotation: involved_in GO:0007019 microtubule depolymerization evidence: IMP reference: PMID:12426374 assigned_by: PomBase - protein: UniProtKB:O14343 symbol: klp5 organism: Schizosaccharomyces pombe annotation: involved_in GO:0070462 plus-end specific microtubule depolymerization evidence: IDA reference: PMID:31427431 assigned_by: PomBase - protein: UniProtKB:O59751 symbol: klp6 organism: Schizosaccharomyces pombe annotation: involved_in GO:0007019 microtubule depolymerization evidence: IMP reference: PMID:12426374 assigned_by: PomBase - protein: UniProtKB:O59751 symbol: klp6 organism: Schizosaccharomyces pombe annotation: involved_in GO:0070462 plus-end specific microtubule depolymerization evidence: IDA reference: PMID:31427431 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN008606205 asserted_term: id: GO:0007019 label: microtubule depolymerization evidence: IRD negated: true seeds: - id: PANTHER:PTN000649974 label: PTN000649974 (ancestral IBD node; IRD source) paint_snapshot: '20240206' node_taxon: id: NCBITaxon:4895 label: Schizosaccharomyces - family: PANTHER:PTHR24229 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 56 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q9VVQ1 symbol: AstC-R1 organism: Drosophila melanogaster annotation: involved_in GO:0007218 neuropeptide signaling pathway evidence: IDA reference: PMID:12167655 assigned_by: FlyBase - protein: UniProtKB:Q9VVQ1 symbol: AstC-R1 organism: Drosophila melanogaster annotation: involved_in GO:0007218 neuropeptide signaling pathway evidence: IDA reference: PMID:14555656 assigned_by: FlyBase - protein: UniProtKB:A0A0S0WMT8 symbol: AstC-R2 organism: Drosophila melanogaster annotation: involved_in GO:0007218 neuropeptide signaling pathway evidence: IDA reference: PMID:12167655 assigned_by: FlyBase - protein: UniProtKB:A0A0S0WMT8 symbol: AstC-R2 organism: Drosophila melanogaster annotation: involved_in GO:0007218 neuropeptide signaling pathway evidence: IDA reference: PMID:14555656 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN002796263 asserted_term: id: GO:0007218 label: neuropeptide signaling pathway evidence: IRD negated: true seeds: - id: PANTHER:PTN000659780 label: PTN000659780 (ancestral IBD node; IRD source) paint_snapshot: '20191118' node_taxon: id: NCBITaxon:33317 label: Protostomia - family: PANTHER:PTHR24361 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q9ES70 symbol: Nek6 organism: Mus musculus annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IDA reference: PMID:20595392 assigned_by: UniProt - protein: UniProtKB:P59895 symbol: Nek6 organism: Rattus norvegicus annotation: enables GO:0004674 protein serine/threonine kinase activity evidence: IDA reference: PMID:11516946 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN007798220 asserted_term: id: GO:0004674 label: protein serine/threonine kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN004700021 label: PTN004700021 (ancestral IBD node; IRD source) paint_snapshot: '20250904' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR45618 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 15 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:P55916 symbol: UCP3 organism: Homo sapiens annotation: enables GO:0017077 oxidative phosphorylation uncoupler activity evidence: IMP reference: PMID:21775425 assigned_by: UniProt - protein: UniProtKB:P55916 symbol: UCP3 organism: Homo sapiens annotation: enables GO:0017077 oxidative phosphorylation uncoupler activity evidence: IDA reference: PMID:36114012 assigned_by: UniProt - protein: UniProtKB:P55916 symbol: UCP3 organism: Homo sapiens annotation: enables GO:0017077 oxidative phosphorylation uncoupler activity evidence: IDA reference: PMID:9305858 assigned_by: UniProt - protein: UniProtKB:P56501 symbol: Ucp3 organism: Mus musculus annotation: enables GO:0017077 oxidative phosphorylation uncoupler activity evidence: IMP reference: PMID:10748195 assigned_by: MGI - protein: UniProtKB:P56501 symbol: Ucp3 organism: Mus musculus annotation: enables GO:0017077 oxidative phosphorylation uncoupler activity evidence: IMP reference: PMID:10748196 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000642212 asserted_term: id: GO:0017077 label: oxidative phosphorylation uncoupler activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000642156 label: PTN000642156 (ancestral IBD node; IRD source) paint_snapshot: '20260530' node_taxon: id: NCBITaxon:40674 label: Mammalia - family: PANTHER:PTHR45619 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 49 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:Q07099 symbol: PP2A1 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: IDA reference: PMID:22404109 assigned_by: TAIR - protein: UniProtKB:Q07098 symbol: PP2A2 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: IDA reference: PMID:22404109 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN001705193 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN001705142 label: PTN001705142 (ancestral IBD node; IRD source) paint_snapshot: '20260530' node_taxon: id: NCBITaxon:1437201 label: Pentapetalae - family: PANTHER:PTHR47958 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 208 proteins_with_low_throughput_positive: 2 conflicting_experimental_annotations: - protein: UniProtKB:P17844 symbol: DDX5 organism: Homo sapiens annotation: enables GO:0003724 RNA helicase activity evidence: IMP reference: PMID:21343338 assigned_by: UniProt - protein: UniProtKB:P24783 symbol: DBP2 organism: Saccharomyces cerevisiae annotation: enables GO:0003724 RNA helicase activity evidence: IDA reference: PMID:23721653 assigned_by: SGD node_assessment: node_id: PANTHER:PTN002773962 asserted_term: id: GO:0003724 label: RNA helicase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002774595 label: PTN002774595 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR10030 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9VTJ4 symbol: Fuca organism: Drosophila melanogaster annotation: enables GO:0004560 alpha-L-fucosidase activity evidence: IDA reference: PMID:16736526 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN000003216 asserted_term: id: GO:0004560 label: alpha-L-fucosidase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000003123 label: PTN000003123 (ancestral IBD node; IRD source) paint_snapshot: '20230405' node_taxon: id: NCBITaxon:7227 label: Drosophila melanogaster - family: PANTHER:PTHR10126 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 39 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P62380 symbol: TBPL1 organism: Homo sapiens annotation: enables GO:0016251 RNA polymerase II general transcription initiation factor activity evidence: IDA reference: PMID:10220372 assigned_by: GO_Central - protein: UniProtKB:P62380 symbol: TBPL1 organism: Homo sapiens annotation: enables GO:0016251 RNA polymerase II general transcription initiation factor activity evidence: IDA reference: PMID:15767669 assigned_by: NTNU_SB node_assessment: node_id: PANTHER:PTN000013141 asserted_term: id: GO:0016251 label: RNA polymerase II general transcription initiation factor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000013137 label: PTN000013137 (ancestral IBD node; IRD source) paint_snapshot: '20200807' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR10134 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 170 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:A0A1D8PJX3 symbol: RIP1 organism: Candida albicans annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:19824013 assigned_by: CGD node_assessment: node_id: PANTHER:PTN000015359 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000015358 label: PTN000015358 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR10196 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 189 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q64516 symbol: Gk organism: Mus musculus annotation: is_active_in GO:0005829 cytosol evidence: IDA reference: PMID:27713003 assigned_by: MGI - protein: UniProtKB:Q9M8L4 symbol: GLPK organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: HDA reference: PMID:25293756 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000023394 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000023392 label: PTN000023392 (ancestral IBD node; IRD source) paint_snapshot: '20241119' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR10288 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 225 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9C7C3 symbol: At3g12130 organism: Arabidopsis thaliana annotation: located_in GO:0005634 nucleus evidence: IDA reference: PMID:29076025 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN002568487 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN000032600 label: PTN000032600 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:3193 label: Embryophyta - family: PANTHER:PTHR10344 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 27 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:D3ZC63 symbol: Cmpk2 organism: Rattus norvegicus annotation: enables GO:0004798 dTMP kinase activity evidence: IDA reference: PMID:192455 assigned_by: RGD node_assessment: node_id: PANTHER:PTN001620248 asserted_term: id: GO:0004798 label: dTMP kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000038985 label: PTN000038985 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR10353 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 61 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q93Y07 symbol: SFR2 organism: Arabidopsis thaliana annotation: enables GO:0008422 beta-glucosidase activity evidence: IDA reference: PMID:15258268 assigned_by: TAIR - protein: UniProtKB:Q93Y07 symbol: SFR2 organism: Arabidopsis thaliana annotation: enables GO:0008422 beta-glucosidase activity evidence: IDA reference: PMID:15258268 assigned_by: UniProt - protein: UniProtKB:Q93Y07 symbol: SFR2 organism: Arabidopsis thaliana annotation: enables GO:0080079 cellobiose glucosidase activity evidence: IDA reference: PMID:15258268 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008498319 asserted_term: id: GO:0008422 label: beta-glucosidase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000039458 label: PTN000039458 (ancestral IBD node; IRD source) paint_snapshot: '20260528' - family: PANTHER:PTHR10424 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 39 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:H2DE99 symbol: CAR1 organism: Canis lupus familiaris annotation: acts_upstream_of_or_within GO:0007520 myoblast fusion evidence: IMP reference: PMID:27589388 assigned_by: MGI node_assessment: node_id: PANTHER:PTN007440286 asserted_term: id: GO:0007520 label: myoblast fusion evidence: IRD negated: true seeds: - id: PANTHER:PTN002572584 label: PTN002572584 (ancestral IBD node; IRD source) paint_snapshot: '20260731' node_taxon: id: NCBITaxon:9347 label: Eutheria - family: PANTHER:PTHR10454 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 6 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:C0H5Y5 symbol: Cflar organism: Rattus norvegicus annotation: part_of GO:0031265 CD95 death-inducing signaling complex evidence: IDA reference: PMID:16493077 assigned_by: RGD node_assessment: node_id: PANTHER:PTN000047958 asserted_term: id: GO:0031265 label: CD95 death-inducing signaling complex evidence: IRD negated: true seeds: - id: PANTHER:PTN002573079 label: PTN002573079 (ancestral IBD node; IRD source) paint_snapshot: '20260616' node_taxon: id: NCBITaxon:314146 label: Euarchontoglires - family: PANTHER:PTHR10513 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 42 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q54UT2 symbol: dgk organism: Dictyostelium discoideum annotation: enables GO:0004138 deoxyguanosine kinase activity evidence: IDA reference: PMID:17448496 assigned_by: dictyBase node_assessment: node_id: PANTHER:PTN000828201 asserted_term: id: GO:0019136 label: deoxynucleoside kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000053758 label: PTN000053758 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR10625 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 42 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9UBN7 symbol: HDAC6 organism: Homo sapiens annotation: involved_in GO:0045814 negative regulation of gene expression, epigenetic evidence: IMP reference: PMID:24413532 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008492157 asserted_term: id: GO:0040029 label: epigenetic regulation of gene expression evidence: IRD negated: true seeds: - id: PANTHER:PTN008143312 label: PTN008143312 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR10648 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q38951 symbol: PP2AA3 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: IDA reference: PMID:22404109 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000068762 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000068663 label: PTN000068663 (ancestral IBD node; IRD source) paint_snapshot: '20250902' node_taxon: id: NCBITaxon:3702 label: Arabidopsis thaliana - family: PANTHER:PTHR10696 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q19000 symbol: gbh-1 organism: Caenorhabditis elegans annotation: involved_in GO:0045329 carnitine biosynthetic process evidence: IMP reference: PMID:41022783 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN000075565 asserted_term: id: GO:0045329 label: carnitine biosynthetic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000075473 label: PTN000075473 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:1206794 label: Ecdysozoa - family: PANTHER:PTHR10953 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 13 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P41226 symbol: UBA7 organism: Homo sapiens annotation: located_in GO:0005634 nucleus evidence: EXP reference: PMID:29743376 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008313461 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN000102404 label: PTN000102404 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:40674 label: Mammalia - family: PANTHER:PTHR11119 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: IDA reference: PMID:10556483 assigned_by: UniProt - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: EXP reference: PMID:10556521 assigned_by: UniProt - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: IDA reference: PMID:10631088 assigned_by: UniProt - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: IDA reference: PMID:11895172 assigned_by: UniProt - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: IDA reference: PMID:15993839 assigned_by: UniProt - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: IDA reference: PMID:18094143 assigned_by: UniProt - protein: UniProtKB:Q9UHI7 symbol: SLC23A1 organism: Homo sapiens annotation: enables GO:0008520 L-ascorbate:sodium symporter activity evidence: IDA reference: PMID:36749388 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002476593 asserted_term: id: GO:0008520 label: L-ascorbate:sodium symporter activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002595861 label: PTN002595861 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:9606 label: Homo sapiens - family: PANTHER:PTHR11207 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 96 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P22192 symbol: pac1 organism: Schizosaccharomyces pombe annotation: enables GO:0003725 double-stranded RNA binding evidence: IDA reference: PMID:8710510 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN000129456 asserted_term: id: GO:0003725 label: double-stranded RNA binding evidence: IRD negated: true seeds: - id: PANTHER:PTN000129453 label: PTN000129453 (ancestral IBD node; IRD source) paint_snapshot: '20220413' node_taxon: id: NCBITaxon:33154 label: Opisthokonta - family: PANTHER:PTHR11237 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P97478 symbol: Coq7 organism: Mus musculus annotation: acts_upstream_of_or_within GO:0006744 ubiquinone biosynthetic process evidence: IMP reference: PMID:11585841 assigned_by: MGI - protein: UniProtKB:P97478 symbol: Coq7 organism: Mus musculus annotation: acts_upstream_of_or_within GO:0006744 ubiquinone biosynthetic process evidence: IMP reference: PMID:11716496 assigned_by: MGI - protein: UniProtKB:P97478 symbol: Coq7 organism: Mus musculus annotation: involved_in GO:0006744 ubiquinone biosynthetic process evidence: IMP reference: PMID:11716496 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000132997 asserted_term: id: GO:0006744 label: ubiquinone biosynthetic process evidence: IRD negated: true seeds: - id: PANTHER:PTN004246703 label: PTN004246703 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:10090 label: Mus musculus - family: PANTHER:PTHR11380 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 15 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P06844 symbol: SPT3 organism: Saccharomyces cerevisiae annotation: involved_in GO:0006366 transcription by RNA polymerase II evidence: IMP reference: PMID:12370284 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000890159 asserted_term: id: GO:0006366 label: transcription by RNA polymerase II evidence: IRD negated: true seeds: - id: PANTHER:PTN000147049 label: PTN000147049 (ancestral IBD node; IRD source) paint_snapshot: '20240729' node_taxon: id: NCBITaxon:4751 label: Fungi - family: PANTHER:PTHR11394 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 21 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9NYW0 symbol: TAS2R10 organism: Homo sapiens annotation: involved_in GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste evidence: IDA reference: PMID:20022913 assigned_by: UniProt - protein: UniProtKB:Q9NYW0 symbol: TAS2R10 organism: Homo sapiens annotation: enables GO:0033038 bitter taste receptor activity evidence: IDA reference: PMID:20022913 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000791689 asserted_term: id: GO:0001580 label: detection of chemical stimulus involved in sensory perception of bitter taste evidence: IRD negated: true seeds: - id: PANTHER:PTN000149628 label: PTN000149628 (ancestral IBD node; IRD source) paint_snapshot: '20231012' node_taxon: id: NCBITaxon:9347 label: Eutheria - family: PANTHER:PTHR11394 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 21 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9NYW0 symbol: TAS2R10 organism: Homo sapiens annotation: enables GO:0033038 bitter taste receptor activity evidence: IDA reference: PMID:20022913 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000791689 asserted_term: id: GO:0033038 label: bitter taste receptor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000149628 label: PTN000149628 (ancestral IBD node; IRD source) paint_snapshot: '20170228' node_taxon: id: NCBITaxon:9347 label: Eutheria - family: PANTHER:PTHR11409 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 151 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q8LPL7 symbol: MAPDA organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: IDA reference: PMID:29884623 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000150819 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000150817 label: PTN000150817 (ancestral IBD node; IRD source) paint_snapshot: '20251218' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11486 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 91 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q8R5L7 symbol: Fgf14 organism: Rattus norvegicus annotation: enables GO:0008083 growth factor activity evidence: IDA reference: PMID:1824921 assigned_by: RGD node_assessment: node_id: PANTHER:PTN000160077 asserted_term: id: GO:0008083 label: growth factor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000160075 label: PTN000160075 (ancestral IBD node; IRD source) paint_snapshot: '20241120' - family: PANTHER:PTHR11524 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 6 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O60143 symbol: rpl701 organism: Schizosaccharomyces pombe annotation: part_of GO:0022625 cytosolic large ribosomal subunit evidence: EXP reference: PMID:39379376 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN000162908 asserted_term: id: GO:0022625 label: cytosolic large ribosomal subunit evidence: IRD negated: true seeds: - id: PANTHER:PTN000897517 label: PTN000897517 (ancestral IBD node; IRD source) paint_snapshot: '20260115' - family: PANTHER:PTHR11584 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 6 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P23561 symbol: STE11 organism: Saccharomyces cerevisiae annotation: involved_in GO:0038066 p38MAPK cascade evidence: IMP reference: PMID:9180081 assigned_by: SGD - protein: UniProtKB:P23561 symbol: STE11 organism: Saccharomyces cerevisiae annotation: involved_in GO:0038066 p38MAPK cascade evidence: IMP reference: PMID:9180081 assigned_by: SGD - protein: UniProtKB:P23561 symbol: STE11 organism: Saccharomyces cerevisiae annotation: involved_in GO:0038066 p38MAPK cascade evidence: IGI reference: PMID:9180081 assigned_by: SGD node_assessment: node_id: PANTHER:PTN007515471 asserted_term: id: GO:0038066 label: p38MAPK cascade evidence: IRD negated: true seeds: - id: PANTHER:PTN000172316 label: PTN000172316 (ancestral IBD node; IRD source) paint_snapshot: '20260114' node_taxon: id: NCBITaxon:4751 label: Fungi - family: PANTHER:PTHR11588 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 62 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P38557 symbol: TUBG1 organism: Arabidopsis thaliana annotation: located_in GO:0005737 cytoplasm evidence: IDA reference: PMID:22144887 assigned_by: UniProt - protein: UniProtKB:P38557 symbol: TUBG1 organism: Arabidopsis thaliana annotation: located_in GO:0005938 cell cortex evidence: IDA reference: PMID:22144887 assigned_by: UniProt - protein: UniProtKB:P38557 symbol: TUBG1 organism: Arabidopsis thaliana annotation: located_in GO:0005737 cytoplasm evidence: HDA reference: PMID:15469496 assigned_by: TAIR - protein: UniProtKB:P38557 symbol: TUBG1 organism: Arabidopsis thaliana annotation: located_in GO:0005739 mitochondrion evidence: HDA reference: PMID:14671022 assigned_by: TAIR - protein: UniProtKB:P38558 symbol: TUBG2 organism: Arabidopsis thaliana annotation: located_in GO:0005737 cytoplasm evidence: HDA reference: PMID:15469496 assigned_by: TAIR - protein: UniProtKB:P38558 symbol: TUBG2 organism: Arabidopsis thaliana annotation: located_in GO:0005739 mitochondrion evidence: HDA reference: PMID:14671022 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000172725 asserted_term: id: GO:0005737 label: cytoplasm evidence: IRD negated: true seeds: - id: PANTHER:PTN000172598 label: PTN000172598 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:33090 label: Viridiplantae - family: PANTHER:PTHR11610 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 9 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P54316 symbol: Pnliprp1 organism: Rattus norvegicus annotation: located_in GO:0005576 extracellular region evidence: IDA reference: PMID:8967484 assigned_by: RGD node_assessment: node_id: PANTHER:PTN000176957 asserted_term: id: GO:0005576 label: extracellular region evidence: IRD negated: true seeds: - id: PANTHER:PTN008325466 label: PTN008325466 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:32525 label: Theria - family: PANTHER:PTHR11670 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q94A28 symbol: ACO2 organism: Arabidopsis thaliana annotation: enables GO:0003994 aconitate hydratase activity evidence: IMP reference: PMID:17013749 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000186783 asserted_term: id: GO:0003994 label: aconitate hydratase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000186700 label: PTN000186700 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:3702 label: Arabidopsis thaliana - family: PANTHER:PTHR11706 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_SUPPORTED clade_size: 3 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q5ACZ8 symbol: SMF3 organism: Candida albicans annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:19824013 assigned_by: CGD node_assessment: node_id: PANTHER:PTN007528568 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000194431 label: PTN000194431 (ancestral IBD node; IRD source) paint_snapshot: '20231101' node_taxon: id: NCBITaxon:2952368 label: Candida/Saccharomycales clade - family: PANTHER:PTHR11717 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P82890 symbol: primo-1 organism: Drosophila melanogaster annotation: enables GO:0004725 protein tyrosine phosphatase activity evidence: IDA reference: PMID:33372666 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN002271066 asserted_term: id: GO:0004725 label: protein tyrosine phosphatase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000197212 label: PTN000197212 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:7227 label: Drosophila melanogaster - family: PANTHER:PTHR11771 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 12 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9BYJ1 symbol: ALOXE3 organism: Homo sapiens annotation: enables GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen evidence: IDA reference: PMID:20921226 assigned_by: UniProt - protein: UniProtKB:Q9BYJ1 symbol: ALOXE3 organism: Homo sapiens annotation: enables GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen evidence: IDA reference: PMID:20923767 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000206222 asserted_term: id: GO:0016702 label: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen evidence: IRD negated: true seeds: - id: PANTHER:PTN000206105 label: PTN000206105 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:32525 label: Theria - family: PANTHER:PTHR11778 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 4 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q95T19 symbol: Slimp organism: Drosophila melanogaster annotation: involved_in GO:0070158 mitochondrial seryl-tRNA aminoacylation evidence: IDA reference: PMID:30943413 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN000925808 asserted_term: id: GO:0006434 label: seryl-tRNA aminoacylation evidence: IRD negated: true seeds: - id: PANTHER:PTN002623036 label: PTN002623036 (ancestral IBD node; IRD source) paint_snapshot: '20260828' - family: PANTHER:PTHR11778 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 4 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q95T19 symbol: Slimp organism: Drosophila melanogaster annotation: involved_in GO:0070158 mitochondrial seryl-tRNA aminoacylation evidence: IDA reference: PMID:30943413 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN000925808 asserted_term: id: GO:0070158 label: mitochondrial seryl-tRNA aminoacylation evidence: IRD negated: true seeds: - id: PANTHER:PTN000207154 label: PTN000207154 (ancestral IBD node; IRD source) paint_snapshot: '20220414' - family: PANTHER:PTHR11811 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 52 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q94KU2 symbol: pgdP organism: Spinacia oleracea annotation: enables GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity evidence: IDA reference: PMID:11322889 assigned_by: UniProt - protein: UniProtKB:Q94KU2 symbol: pgdP organism: Spinacia oleracea annotation: enables GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity evidence: IDA reference: PMID:11322889 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000211991 asserted_term: id: GO:0004616 label: phosphogluconate dehydrogenase (decarboxylating) activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000211910 label: PTN000211910 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:3398 label: Magnoliopsida - family: PANTHER:PTHR11831 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 112 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q683D4 symbol: At5g15750 organism: Arabidopsis thaliana annotation: enables GO:0003735 structural constituent of ribosome evidence: IDA reference: PMID:17934214 assigned_by: CAFA node_assessment: node_id: PANTHER:PTN000216482 asserted_term: id: GO:0003735 label: structural constituent of ribosome evidence: IRD negated: true seeds: - id: PANTHER:PTN000216478 label: PTN000216478 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11934 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 65 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P47968 symbol: Rpia organism: Mus musculus annotation: is_active_in GO:0005829 cytosol evidence: IDA reference: PMID:5360673 assigned_by: MGI node_assessment: node_id: PANTHER:PTN000232509 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000232507 label: PTN000232507 (ancestral IBD node; IRD source) paint_snapshot: '20220922' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11937 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 119 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P61160 symbol: ACTR2 organism: Homo sapiens annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IDA reference: PMID:11741539 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN000233596 asserted_term: id: GO:0005200 label: structural constituent of cytoskeleton evidence: IRD negated: true seeds: - id: PANTHER:PTN000940351 label: PTN000940351 (ancestral IBD node; IRD source) paint_snapshot: '20260416' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11937 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 153 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P61158 symbol: ACTR3 organism: Homo sapiens annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IDA reference: PMID:11741539 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN000233796 asserted_term: id: GO:0005200 label: structural constituent of cytoskeleton evidence: IRD negated: true seeds: - id: PANTHER:PTN000940351 label: PTN000940351 (ancestral IBD node; IRD source) paint_snapshot: '20260416' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11937 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 107 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q04549 symbol: ARP10 organism: Saccharomyces cerevisiae annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IPI reference: PMID:16291862 assigned_by: SGD - protein: UniProtKB:Q04549 symbol: ARP10 organism: Saccharomyces cerevisiae annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IPI reference: PMID:16291862 assigned_by: SGD - protein: UniProtKB:Q04549 symbol: ARP10 organism: Saccharomyces cerevisiae annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IPI reference: PMID:16291862 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000233887 asserted_term: id: GO:0005200 label: structural constituent of cytoskeleton evidence: IRD negated: true seeds: - id: PANTHER:PTN000940351 label: PTN000940351 (ancestral IBD node; IRD source) paint_snapshot: '20250805' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11937 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 96 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P38696 symbol: ARP1 organism: Saccharomyces cerevisiae annotation: enables GO:0005200 structural constituent of cytoskeleton evidence: IDA reference: PMID:9658168 assigned_by: SGD node_assessment: node_id: PANTHER:PTN007551901 asserted_term: id: GO:0005200 label: structural constituent of cytoskeleton evidence: IRD negated: true seeds: - id: PANTHER:PTN000940351 label: PTN000940351 (ancestral IBD node; IRD source) paint_snapshot: '20260416' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11943 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 2 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9HDU5 symbol: gal7 organism: Schizosaccharomyces pombe annotation: involved_in GO:0033499 beta-D-galactose catabolic process via UDP-galactose, Leloir pathway evidence: EXP reference: PMID:21075050 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN008530881 asserted_term: id: GO:0033499 label: beta-D-galactose catabolic process via UDP-galactose, Leloir pathway evidence: IRD negated: true seeds: - id: PANTHER:PTN000235304 label: PTN000235304 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:4895 label: Schizosaccharomyces - family: PANTHER:PTHR11972 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q8RWS6 symbol: FRO6 organism: Arabidopsis thaliana annotation: enables GO:0000293 ferric-chelate reductase activity evidence: IDA reference: PMID:18647837 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN001379754 asserted_term: id: GO:0000293 label: ferric-chelate reductase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000944413 label: PTN000944413 (ancestral IBD node; IRD source) paint_snapshot: '20181121' node_taxon: id: NCBITaxon:3702 label: Arabidopsis thaliana - family: PANTHER:PTHR11972 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_TOO_BROAD clade_size: 42 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P53109 symbol: AIM14 organism: Saccharomyces cerevisiae annotation: enables GO:0016175 superoxide-generating NAD(P)H oxidase activity evidence: IMP reference: PMID:22586098 assigned_by: SGD node_assessment: node_id: PANTHER:PTN002279285 asserted_term: id: GO:0016175 label: superoxide-generating NAD(P)H oxidase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000239644 label: PTN000239644 (ancestral IBD node; IRD source) paint_snapshot: '20230405' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR12121 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 393 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:A8MS41 symbol: CCR4-4 organism: Arabidopsis thaliana annotation: acts_upstream_of_or_within GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening evidence: IDA reference: PMID:26619288 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN002637014 asserted_term: id: GO:0000289 label: nuclear-transcribed mRNA poly(A) tail shortening evidence: IRD negated: true seeds: - id: PANTHER:PTN000950416 label: PTN000950416 (ancestral IBD node; IRD source) paint_snapshot: '20260115' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR12121 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 393 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:A8MS41 symbol: CCR4-4 organism: Arabidopsis thaliana annotation: enables GO:0004535 poly(A)-specific ribonuclease activity evidence: EXP reference: PMID:26619288 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002637014 asserted_term: id: GO:0004535 label: poly(A)-specific ribonuclease activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000950416 label: PTN000950416 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR12210 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_SUPPORTED clade_size: 288 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q3ZCQ8 symbol: TIMM50 organism: Homo sapiens annotation: enables GO:0004721 phosphoprotein phosphatase activity evidence: IDA reference: PMID:15044455 assigned_by: MGI - protein: UniProtKB:Q3ZCQ8 symbol: TIMM50 organism: Homo sapiens annotation: enables GO:0004722 protein serine/threonine phosphatase activity evidence: IDA reference: PMID:15044455 assigned_by: UniProt - protein: UniProtKB:Q3ZCQ8 symbol: TIMM50 organism: Homo sapiens annotation: enables GO:0004725 protein tyrosine phosphatase activity evidence: IDA reference: PMID:15044455 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002639282 asserted_term: id: GO:0004721 label: phosphoprotein phosphatase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000258719 label: PTN000258719 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR12317 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 41 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q6ZPD8 symbol: DGAT2L6 organism: Homo sapiens annotation: enables GO:0004144 diacylglycerol O-acyltransferase activity evidence: EXP reference: PMID:15671038 assigned_by: Reactome node_assessment: node_id: PANTHER:PTN000268139 asserted_term: id: GO:0004144 label: diacylglycerol O-acyltransferase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000268127 label: PTN000268127 (ancestral IBD node; IRD source) paint_snapshot: '20250903' node_taxon: id: NCBITaxon:32523 label: Tetrapoda - family: PANTHER:PTHR12400 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 31 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q12494 symbol: KCS1 organism: Saccharomyces cerevisiae annotation: enables GO:0000828 inositol hexakisphosphate kinase activity evidence: IDA reference: PMID:10574768 assigned_by: SGD - protein: UniProtKB:Q12494 symbol: KCS1 organism: Saccharomyces cerevisiae annotation: enables GO:0000828 inositol hexakisphosphate kinase activity evidence: IDA reference: PMID:11956213 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000963723 asserted_term: id: GO:0000828 label: inositol hexakisphosphate kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000274018 label: PTN000274018 (ancestral IBD node; IRD source) paint_snapshot: '20240205' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR12483 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 20 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O15432 symbol: SLC31A2 organism: Homo sapiens annotation: enables GO:0005375 copper ion transmembrane transporter activity evidence: IDA reference: PMID:17617060 assigned_by: UniProt - protein: UniProtKB:O15432 symbol: SLC31A2 organism: Homo sapiens annotation: enables GO:0005375 copper ion transmembrane transporter activity evidence: IDA reference: PMID:17944601 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002647802 asserted_term: id: GO:0005375 label: copper ion transmembrane transporter activity evidence: IRD negated: true seeds: - id: PANTHER:PTN004363803 label: PTN004363803 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR12483 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 20 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O15432 symbol: SLC31A2 organism: Homo sapiens annotation: involved_in GO:0015677 copper ion import evidence: IDA reference: PMID:17944601 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002647802 asserted_term: id: GO:0015677 label: copper ion import evidence: IRD negated: true seeds: - id: PANTHER:PTN008340544 label: PTN008340544 (ancestral IBD node; IRD source) paint_snapshot: '20250701' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR12483 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 20 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O15432 symbol: SLC31A2 organism: Homo sapiens annotation: enables GO:0005375 copper ion transmembrane transporter activity evidence: IDA reference: PMID:17617060 assigned_by: UniProt - protein: UniProtKB:O15432 symbol: SLC31A2 organism: Homo sapiens annotation: enables GO:0005375 copper ion transmembrane transporter activity evidence: IDA reference: PMID:17944601 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002647802 asserted_term: id: GO:0035434 label: copper ion transmembrane transport evidence: IRD negated: true seeds: - id: PANTHER:PTN004363803 label: PTN004363803 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR12737 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 18 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q3SX44 symbol: DDAH2 organism: Bos taurus annotation: involved_in GO:0045429 positive regulation of nitric oxide biosynthetic process evidence: IDA reference: PMID:19820234 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002653588 asserted_term: id: GO:0045429 label: positive regulation of nitric oxide biosynthetic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000978164 label: PTN000978164 (ancestral IBD node; IRD source) paint_snapshot: '20230718' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR12929 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 4 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9NWF4 symbol: SLC52A1 organism: Homo sapiens annotation: enables GO:0032217 riboflavin transmembrane transporter activity evidence: IDA reference: PMID:20463145 assigned_by: UniProt - protein: UniProtKB:Q9NWF4 symbol: SLC52A1 organism: Homo sapiens annotation: enables GO:0032217 riboflavin transmembrane transporter activity evidence: IDA reference: PMID:21854757 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000309189 asserted_term: id: GO:0032217 label: riboflavin transmembrane transporter activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000986065 label: PTN000986065 (ancestral IBD node; IRD source) paint_snapshot: '20260616' node_taxon: id: NCBITaxon:9526 label: Catarrhini - family: PANTHER:PTHR12929 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 4 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9NWF4 symbol: SLC52A1 organism: Homo sapiens annotation: enables GO:0032217 riboflavin transmembrane transporter activity evidence: IDA reference: PMID:20463145 assigned_by: UniProt - protein: UniProtKB:Q9NWF4 symbol: SLC52A1 organism: Homo sapiens annotation: enables GO:0032217 riboflavin transmembrane transporter activity evidence: IDA reference: PMID:21854757 assigned_by: UniProt - protein: UniProtKB:Q9NWF4 symbol: SLC52A1 organism: Homo sapiens annotation: involved_in GO:0032218 riboflavin transport evidence: IDA reference: PMID:20463145 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000309189 asserted_term: id: GO:0032218 label: riboflavin transport evidence: IRD negated: true seeds: - id: PANTHER:PTN000986065 label: PTN000986065 (ancestral IBD node; IRD source) paint_snapshot: '20260616' node_taxon: id: NCBITaxon:9526 label: Catarrhini - family: PANTHER:PTHR13112 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 24 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9H1J1 symbol: UPF3A organism: Homo sapiens annotation: enables GO:0003729 mRNA binding evidence: IDA reference: PMID:11163187 assigned_by: GO_Central node_assessment: node_id: PANTHER:PTN002661716 asserted_term: id: GO:0003729 label: mRNA binding evidence: IRD negated: true seeds: - id: PANTHER:PTN000318879 label: PTN000318879 (ancestral IBD node; IRD source) paint_snapshot: '20220923' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR13336 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 16 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q56VL3 symbol: OCIAD2 organism: Homo sapiens annotation: located_in GO:0005768 endosome evidence: IDA reference: PMID:29743632 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002666459 asserted_term: id: GO:0005768 label: endosome evidence: IRD negated: true seeds: - id: PANTHER:PTN001410694 label: PTN001410694 (ancestral IBD node; IRD source) paint_snapshot: '20250903' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR13354 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 20 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q6PCB5 symbol: RSBN1L organism: Homo sapiens annotation: located_in GO:0016607 nuclear speck evidence: IDA reference: GO_REF:0000052 assigned_by: HPA node_assessment: node_id: PANTHER:PTN002666773 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN002666767 label: PTN002666767 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR13479 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 32 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9NVS2 symbol: MRPS18A organism: Homo sapiens annotation: part_of GO:0005763 mitochondrial small ribosomal subunit evidence: IDA reference: PMID:25838379 assigned_by: UniProt - protein: UniProtKB:P82919 symbol: MRPS18A organism: Bos taurus annotation: part_of GO:0005763 mitochondrial small ribosomal subunit evidence: HDA reference: PMID:11402041 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008549198 asserted_term: id: GO:0005763 label: mitochondrial small ribosomal subunit evidence: IRD negated: true seeds: - id: PANTHER:PTN000336667 label: PTN000336667 (ancestral IBD node; IRD source) paint_snapshot: '20260706' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR13723 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 23 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9EPX2 symbol: Papln organism: Mus musculus annotation: located_in GO:0005604 basement membrane evidence: IDA reference: PMID:18757743 assigned_by: MGI - protein: UniProtKB:Q9EPX2 symbol: Papln organism: Mus musculus annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:22159717 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002673087 asserted_term: id: GO:0031012 label: extracellular matrix evidence: IRD negated: true seeds: - id: PANTHER:PTN000347317 label: PTN000347317 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR13723 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q868Z9 symbol: Ppn organism: Drosophila melanogaster annotation: involved_in GO:0030198 extracellular matrix organization evidence: IMP reference: PMID:11076767 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002673239 asserted_term: id: GO:0030198 label: extracellular matrix organization evidence: IRD negated: true seeds: - id: PANTHER:PTN000347317 label: PTN000347317 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:33317 label: Protostomia - family: PANTHER:PTHR13800 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 24 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q7TN37 symbol: Trpm4 organism: Mus musculus annotation: enables GO:0005262 calcium channel activity evidence: IDA reference: PMID:12893253 assigned_by: MGI node_assessment: node_id: PANTHER:PTN002674361 asserted_term: id: GO:0070588 label: calcium ion transmembrane transport evidence: IRD negated: true seeds: - id: PANTHER:PTN002492758 label: PTN002492758 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR13802 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 35 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q63661 symbol: Muc4 organism: Rattus norvegicus annotation: located_in GO:0016324 apical plasma membrane evidence: IDA reference: PMID:15499570 assigned_by: RGD - protein: UniProtKB:Q63661 symbol: Muc4 organism: Rattus norvegicus annotation: located_in GO:0031528 microvillus membrane evidence: IDA reference: PMID:2674161 assigned_by: RGD node_assessment: node_id: PANTHER:PTN008551513 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN001346488 label: PTN001346488 (ancestral IBD node; IRD source) paint_snapshot: '20250702' node_taxon: id: NCBITaxon:33511 label: Deuterostomia - family: PANTHER:PTHR13914 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 25 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9UF12 symbol: PRODH2 organism: Homo sapiens annotation: enables GO:0004657 proline dehydrogenase activity evidence: EXP reference: PMID:25697095 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008552764 asserted_term: id: GO:0004657 label: proline dehydrogenase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN004447157 label: PTN004447157 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:33511 label: Deuterostomia - family: PANTHER:PTHR13935 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:M0QWB7 symbol: Ascl5 organism: Mus musculus annotation: enables GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific evidence: IMP reference: PMID:30426815 assigned_by: UniProt - protein: UniProtKB:M0QWB7 symbol: Ascl5 organism: Mus musculus annotation: involved_in GO:0045944 positive regulation of transcription by RNA polymerase II evidence: IMP reference: PMID:30426815 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN007629341 asserted_term: id: GO:0045944 label: positive regulation of transcription by RNA polymerase II evidence: IRD negated: true seeds: - id: PANTHER:PTN001420656 label: PTN001420656 (ancestral IBD node; IRD source) paint_snapshot: '20240918' node_taxon: id: NCBITaxon:40674 label: Mammalia - family: PANTHER:PTHR13944 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 19 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q12802 symbol: AKAP13 organism: Homo sapiens annotation: enables GO:0005085 guanyl-nucleotide exchange factor activity evidence: IDA reference: PMID:11546812 assigned_by: UniProt - protein: UniProtKB:Q12802 symbol: AKAP13 organism: Homo sapiens annotation: enables GO:0005085 guanyl-nucleotide exchange factor activity evidence: IDA reference: PMID:25186459 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002677811 asserted_term: id: GO:0005085 label: guanyl-nucleotide exchange factor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002677784 label: PTN002677784 (ancestral IBD node; IRD source) paint_snapshot: '20250516' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR14021 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 47 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q8L7K4 symbol: HSCB organism: Arabidopsis thaliana annotation: located_in GO:0005739 mitochondrion evidence: IDA reference: PMID:19865480 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000361333 asserted_term: id: GO:0005739 label: mitochondrion evidence: IRD negated: true seeds: - id: PANTHER:PTN000361285 label: PTN000361285 (ancestral IBD node; IRD source) paint_snapshot: '20170228' node_taxon: id: NCBITaxon:33090 label: Viridiplantae - family: PANTHER:PTHR14149 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 2 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q54K32 symbol: rgaA organism: Dictyostelium discoideum annotation: enables GO:0005096 GTPase activator activity evidence: IDA reference: PMID:9056774 assigned_by: dictyBase node_assessment: node_id: PANTHER:PTN001020773 asserted_term: id: GO:0005096 label: GTPase activator activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000365540 label: PTN000365540 (ancestral IBD node; IRD source) paint_snapshot: '20240918' node_taxon: id: NCBITaxon:5782 label: Dictyostelium - family: PANTHER:PTHR14167 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 66 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q69ZI1 symbol: Sh3rf1 organism: Mus musculus annotation: enables GO:0005078 MAP kinase scaffold activity evidence: IPI reference: PMID:23963642 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000070286 asserted_term: id: GO:0030674 label: protein-macromolecule adaptor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN009017043 label: PTN009017043 (ancestral IBD node; IRD source) paint_snapshot: '20250821' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR15160 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 2 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P40337 symbol: VHL organism: Homo sapiens annotation: located_in GO:0005634 nucleus evidence: EXP reference: PMID:9751722 assigned_by: UniProt - protein: UniProtKB:P40337 symbol: VHL organism: Homo sapiens annotation: located_in GO:0005654 nucleoplasm evidence: IDA reference: GO_REF:0000052 assigned_by: HPA node_assessment: node_id: PANTHER:PTN000389250 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN000389240 label: PTN000389240 (ancestral IBD node; IRD source) paint_snapshot: '20260529' - family: PANTHER:PTHR15282 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 3 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P15383 symbol: Kcne1 organism: Rattus norvegicus annotation: enables GO:0005251 delayed rectifier potassium channel activity evidence: IMP reference: PMID:11810210 assigned_by: RGD node_assessment: node_id: PANTHER:PTN002691489 asserted_term: id: GO:0005251 label: delayed rectifier potassium channel activity evidence: IRD negated: true seeds: - id: PANTHER:PTN001445835 label: PTN001445835 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:9347 label: Eutheria - family: PANTHER:PTHR15375 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9Y7J1 symbol: spo6 organism: Schizosaccharomyces pombe annotation: part_of GO:0031431 Dbf4-dependent protein kinase complex evidence: IDA reference: PMID:11739743 assigned_by: PomBase - protein: UniProtKB:Q9Y7J1 symbol: spo6 organism: Schizosaccharomyces pombe annotation: part_of GO:0031431 Dbf4-dependent protein kinase complex evidence: IPI reference: PMID:11739743 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN000395053 asserted_term: id: GO:0031431 label: Dbf4-dependent protein kinase complex evidence: IRD negated: true seeds: - id: PANTHER:PTN002310337 label: PTN002310337 (ancestral IBD node; IRD source) paint_snapshot: '20251219' node_taxon: id: NCBITaxon:284812 label: Schizosaccharomyces pombe (strain 972 / ATCC 24843) - family: PANTHER:PTHR15730 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 15 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:A6NFQ2 symbol: TCAF2 organism: Homo sapiens annotation: involved_in GO:0090314 positive regulation of protein targeting to membrane evidence: IMP reference: PMID:25559186 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000404861 asserted_term: id: GO:0090314 label: positive regulation of protein targeting to membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN002696670 label: PTN002696670 (ancestral IBD node; IRD source) paint_snapshot: '20260127' node_taxon: id: NCBITaxon:9347 label: Eutheria - family: PANTHER:PTHR16943 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 44 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O06582 symbol: prpD organism: Mycobacterium tuberculosis annotation: involved_in GO:0019543 propionate catabolic process evidence: IMP reference: PMID:18375549 assigned_by: MTBBASE node_assessment: node_id: PANTHER:PTN000424252 asserted_term: id: GO:0019541 label: propionate metabolic process evidence: IRD negated: true seeds: - id: PANTHER:PTN008565288 label: PTN008565288 (ancestral IBD node; IRD source) paint_snapshot: '20260529' - family: PANTHER:PTHR18929 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 22 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9DAN1 symbol: Pdilt organism: Mus musculus annotation: enables GO:0003756 protein disulfide isomerase activity evidence: IMP reference: PMID:22357757 assigned_by: MGI node_assessment: node_id: PANTHER:PTN002706902 asserted_term: id: GO:0003756 label: protein disulfide isomerase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000432607 label: PTN000432607 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR18945 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 24 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P23979 symbol: Htr3a organism: Mus musculus annotation: enables GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential evidence: IDA reference: PMID:25989383 assigned_by: SynGO - protein: UniProtKB:P23979 symbol: Htr3a organism: Mus musculus annotation: enables GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential evidence: IMP reference: PMID:25989383 assigned_by: SynGO - protein: UniProtKB:P23979 symbol: Htr3a organism: Mus musculus annotation: enables GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential evidence: IDA reference: PMID:25989383 assigned_by: SynGO node_assessment: node_id: PANTHER:PTN002707854 asserted_term: id: GO:0042391 label: regulation of membrane potential evidence: IRD negated: true seeds: - id: PANTHER:PTN000434994 label: PTN000434994 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR18966 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 7 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9V4A0 symbol: DmelCG11155 organism: Drosophila melanogaster annotation: involved_in GO:0031915 positive regulation of synaptic plasticity evidence: IMP reference: PMID:38569548 assigned_by: FlyBase node_assessment: node_id: PANTHER:PTN001826347 asserted_term: id: GO:0050804 label: modulation of chemical synaptic transmission evidence: IRD negated: true seeds: - id: PANTHER:PTN001826301 label: PTN001826301 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:6656 label: Arthropoda - family: PANTHER:PTHR19139 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9WTY0 symbol: Aqp6 organism: Rattus norvegicus annotation: enables GO:0035379 carbon dioxide transmembrane transporter activity evidence: IDA reference: PMID:23485707 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN001452348 asserted_term: id: GO:0015670 label: carbon dioxide transport evidence: IRD negated: true seeds: - id: PANTHER:PTN008567822 label: PTN008567822 (ancestral IBD node; IRD source) paint_snapshot: '20240924' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR19375 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_TOO_BROAD clade_size: 57 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P10591 symbol: SSA1 organism: Saccharomyces cerevisiae annotation: involved_in GO:0042026 protein refolding evidence: IDA reference: PMID:18706386 assigned_by: SGD - protein: UniProtKB:P10591 symbol: SSA1 organism: Saccharomyces cerevisiae annotation: involved_in GO:0042026 protein refolding evidence: IDA reference: PMID:9674429 assigned_by: SGD node_assessment: node_id: PANTHER:PTN001065099 asserted_term: id: GO:0042026 label: protein refolding evidence: IRD negated: true seeds: - id: PANTHER:PTN000452648 label: PTN000452648 (ancestral IBD node; IRD source) paint_snapshot: '20260616' node_taxon: id: NCBITaxon:4751 label: Fungi - family: PANTHER:PTHR19842 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9W328 symbol: Lst8 organism: Drosophila melanogaster annotation: part_of GO:0031931 TORC1 complex evidence: IDA reference: PMID:22493059 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN000457125 asserted_term: id: GO:0031931 label: TORC1 complex evidence: IRD negated: true seeds: - id: PANTHER:PTN000457085 label: PTN000457085 (ancestral IBD node; IRD source) paint_snapshot: '20211129' node_taxon: id: NCBITaxon:7227 label: Drosophila melanogaster - family: PANTHER:PTHR19878 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 16 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q6KAU8 symbol: Atg16l2 organism: Mus musculus annotation: involved_in GO:0000045 autophagosome assembly evidence: IMP reference: PMID:11266458 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN002716574 asserted_term: id: GO:0000045 label: autophagosome assembly evidence: IRD negated: true seeds: - id: PANTHER:PTN000459085 label: PTN000459085 (ancestral IBD node; IRD source) paint_snapshot: '20251219' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR19878 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 16 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q6KAU8 symbol: Atg16l2 organism: Mus musculus annotation: located_in GO:0034045 phagophore assembly site membrane evidence: IDA reference: PMID:12665549 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN002716574 asserted_term: id: GO:0034045 label: phagophore assembly site membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000459085 label: PTN000459085 (ancestral IBD node; IRD source) paint_snapshot: '20250412' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR19965 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 27 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q12159 symbol: YRA1 organism: Saccharomyces cerevisiae annotation: involved_in GO:0006406 mRNA export from nucleus evidence: IGI reference: PMID:11979277 assigned_by: SGD node_assessment: node_id: PANTHER:PTN001072467 asserted_term: id: GO:0006406 label: mRNA export from nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN000462807 label: PTN000462807 (ancestral IBD node; IRD source) paint_snapshot: '20240731' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR20275 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 16 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q06892 symbol: POS5 organism: Saccharomyces cerevisiae annotation: involved_in GO:0006741 NADP+ biosynthetic process evidence: IDA reference: PMID:12727869 assigned_by: SGD node_assessment: node_id: PANTHER:PTN001072874 asserted_term: id: GO:0006741 label: NADP+ biosynthetic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000463643 label: PTN000463643 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:4751 label: Fungi - family: PANTHER:PTHR20275 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 56 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q500Y9 symbol: NADK3 organism: Arabidopsis thaliana annotation: enables GO:0003951 NAD+ kinase activity evidence: IDA reference: PMID:15347288 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN008367271 asserted_term: id: GO:0003951 label: NAD+ kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000463643 label: PTN000463643 (ancestral IBD node; IRD source) paint_snapshot: '20250728' node_taxon: id: NCBITaxon:2698737 label: Sar - family: PANTHER:PTHR20275 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 56 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q500Y9 symbol: NADK3 organism: Arabidopsis thaliana annotation: acts_upstream_of_or_within GO:0006741 NADP+ biosynthetic process evidence: IMP reference: PMID:16856986 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN008367271 asserted_term: id: GO:0006741 label: NADP+ biosynthetic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000463643 label: PTN000463643 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:2698737 label: Sar - family: PANTHER:PTHR21257 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 17 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q14739 symbol: LBR organism: Homo sapiens annotation: located_in GO:0005789 endoplasmic reticulum membrane evidence: IDA reference: PMID:21327084 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000479247 asserted_term: id: GO:0005789 label: endoplasmic reticulum membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000479179 label: PTN000479179 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:32523 label: Tetrapoda - family: PANTHER:PTHR21646 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_SUPPORTED clade_size: 121 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q53GS9 symbol: USP39 organism: Homo sapiens annotation: enables GO:0004843 cysteine-type deubiquitinase activity evidence: EXP reference: PMID:30771428 assigned_by: UniProt - protein: UniProtKB:Q53GS9 symbol: USP39 organism: Homo sapiens annotation: enables GO:0004843 cysteine-type deubiquitinase activity evidence: EXP reference: PMID:36651806 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN001922764 asserted_term: id: GO:0004843 label: cysteine-type deubiquitinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002538135 label: PTN002538135 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR22589 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 17 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:F1LN46 symbol: Cpt1c organism: Rattus norvegicus annotation: enables GO:0004095 carnitine O-palmitoyltransferase activity evidence: IDA reference: PMID:18192268 assigned_by: RGD node_assessment: node_id: PANTHER:PTN008579947 asserted_term: id: GO:0004095 label: carnitine O-palmitoyltransferase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN001097100 label: PTN001097100 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:32523 label: Tetrapoda - family: PANTHER:PTHR22804 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 178 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P55068 symbol: Bcan organism: Rattus norvegicus annotation: located_in GO:0097060 synaptic membrane evidence: IDA reference: PMID:7592978 assigned_by: RGD node_assessment: node_id: PANTHER:PTN008374273 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN001169994 label: PTN001169994 (ancestral IBD node; IRD source) paint_snapshot: '20240731' node_taxon: id: NCBITaxon:7711 label: Chordata - family: PANTHER:PTHR23024 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 34 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9LVB8 symbol: CXE20 organism: Arabidopsis thaliana annotation: enables GO:0106435 carboxylesterase activity evidence: IDA reference: PMID:33986761 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN004595044 asserted_term: id: GO:0106435 label: carboxylesterase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN008378658 label: PTN008378658 (ancestral IBD node; IRD source) paint_snapshot: '20260729' - family: PANTHER:PTHR23092 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 2 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O74518 symbol: cid12 organism: Schizosaccharomyces pombe annotation: involved_in GO:1990431 priRNA 3'-end processing evidence: IMP reference: PMID:20178743 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN008590285 asserted_term: id: GO:0031123 label: RNA 3'-end processing evidence: IRD negated: true seeds: - id: PANTHER:PTN000558564 label: PTN000558564 (ancestral IBD node; IRD source) paint_snapshot: '20250412' node_taxon: id: NCBITaxon:4895 label: Schizosaccharomyces - family: PANTHER:PTHR23123 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 21 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q6PCT2 symbol: FBXL19 organism: Homo sapiens annotation: located_in GO:0005634 nucleus evidence: EXP reference: PMID:29522376 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008591189 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN000564171 label: PTN000564171 (ancestral IBD node; IRD source) paint_snapshot: '20260601' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR23159 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 14 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9BZW7 symbol: TSGA10 organism: Homo sapiens annotation: located_in GO:0005814 centriole evidence: IDA reference: GO_REF:0000052 assigned_by: HPA node_assessment: node_id: PANTHER:PTN002753040 asserted_term: id: GO:0005814 label: centriole evidence: IRD negated: true seeds: - id: PANTHER:PTN000570213 label: PTN000570213 (ancestral IBD node; IRD source) paint_snapshot: '20251220' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR23255 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 22 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P70539 symbol: Acvr1c organism: Rattus norvegicus annotation: enables GO:0048185 activin binding evidence: IDA reference: PMID:15196700 assigned_by: MGI node_assessment: node_id: PANTHER:PTN002758343 asserted_term: id: GO:0048185 label: activin binding evidence: IRD negated: true seeds: - id: PANTHER:PTN000583887 label: PTN000583887 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR23355 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 3 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O14040 symbol: dis32 organism: Schizosaccharomyces pombe annotation: enables GO:0000175 3'-5'-RNA exonuclease activity evidence: IDA reference: PMID:23503588 assigned_by: PomBase - protein: UniProtKB:O14040 symbol: dis32 organism: Schizosaccharomyces pombe annotation: enables GO:0000175 3'-5'-RNA exonuclease activity evidence: IDA reference: PMID:23503588 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN008598433 asserted_term: id: GO:0000175 label: 3'-5'-RNA exonuclease activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000599170 label: PTN000599170 (ancestral IBD node; IRD source) paint_snapshot: '20240731' node_taxon: id: NCBITaxon:4895 label: Schizosaccharomyces - family: PANTHER:PTHR23355 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 3 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O14040 symbol: dis32 organism: Schizosaccharomyces pombe annotation: involved_in GO:0000956 nuclear-transcribed mRNA catabolic process evidence: IMP reference: PMID:23503588 assigned_by: UniProt - protein: UniProtKB:O14040 symbol: dis32 organism: Schizosaccharomyces pombe annotation: involved_in GO:1990074 polyuridylation-dependent mRNA catabolic process evidence: IMP reference: PMID:23503588 assigned_by: PomBase - protein: UniProtKB:O14040 symbol: dis32 organism: Schizosaccharomyces pombe annotation: involved_in GO:1990074 polyuridylation-dependent mRNA catabolic process evidence: IMP reference: PMID:23503588 assigned_by: UniProt - protein: UniProtKB:O14040 symbol: dis32 organism: Schizosaccharomyces pombe annotation: involved_in GO:1990074 polyuridylation-dependent mRNA catabolic process evidence: IGI reference: PMID:39333464 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN008598433 asserted_term: id: GO:0006402 label: mRNA catabolic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000599171 label: PTN000599171 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:4895 label: Schizosaccharomyces - family: PANTHER:PTHR23359 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 27 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P27144 symbol: AK4 organism: Homo sapiens annotation: enables GO:0004017 AMP kinase activity evidence: IDA reference: PMID:19766732 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002764060 asserted_term: id: GO:0004017 label: AMP kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000599576 label: PTN000599576 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR23359 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 27 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P27144 symbol: AK4 organism: Homo sapiens annotation: enables GO:0046899 nucleoside triphosphate adenylate kinase activity evidence: IDA reference: PMID:19766732 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002764060 asserted_term: id: GO:0046899 label: nucleoside triphosphate adenylate kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN008598552 label: PTN008598552 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR23359 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 21 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9Y6K8 symbol: AK5 organism: Homo sapiens annotation: enables GO:0004017 AMP kinase activity evidence: EXP reference: PMID:19647735 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002764136 asserted_term: id: GO:0004017 label: AMP kinase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000599576 label: PTN000599576 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR23502 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 7 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O74829 symbol: SPBC530.15c organism: Schizosaccharomyces pombe annotation: located_in GO:0005886 plasma membrane evidence: EXP reference: PMID:39662831 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000607234 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN001160522 label: PTN001160522 (ancestral IBD node; IRD source) paint_snapshot: '20260529' - family: PANTHER:PTHR23502 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 2 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:A0A1D8PJQ4 symbol: CAALFM_C303440CA organism: Candida albicans annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:19824013 assigned_by: CGD node_assessment: node_id: PANTHER:PTN001161987 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN001160522 label: PTN001160522 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:4892 label: Saccharomycetales - family: PANTHER:PTHR24031 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 45 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P60842 symbol: EIF4A1 organism: Homo sapiens annotation: located_in GO:0097165 nuclear stress granule evidence: IDA reference: PMID:20156963 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002777153 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN002777147 label: PTN002777147 (ancestral IBD node; IRD source) paint_snapshot: '20260803' - family: PANTHER:PTHR24073 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 10 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9H0T7 symbol: RAB17 organism: Homo sapiens annotation: located_in GO:0030139 endocytic vesicle evidence: IDA reference: PMID:17646400 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN000634696 asserted_term: id: GO:0030139 label: endocytic vesicle evidence: IRD negated: true seeds: - id: PANTHER:PTN000634566 label: PTN000634566 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR24073 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 19 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O14966 symbol: RAB29 organism: Homo sapiens annotation: located_in GO:0005739 mitochondrion evidence: IDA reference: PMID:25767741 assigned_by: ParkinsonsUK-UCL node_assessment: node_id: PANTHER:PTN001179388 asserted_term: id: GO:0005739 label: mitochondrion evidence: IRD negated: true seeds: - id: PANTHER:PTN000636119 label: PTN000636119 (ancestral IBD node; IRD source) paint_snapshot: '20241120' node_taxon: id: NCBITaxon:6072 label: Eumetazoa - family: PANTHER:PTHR28540 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q4V925 symbol: bad organism: Danio rerio annotation: acts_upstream_of_or_within GO:0043065 positive regulation of apoptotic process evidence: IDA reference: PMID:12727206 assigned_by: ZFIN - protein: UniProtKB:Q4V925 symbol: bad organism: Danio rerio annotation: acts_upstream_of_or_within GO:0043065 positive regulation of apoptotic process evidence: IGI reference: PMID:16543226 assigned_by: ZFIN - protein: UniProtKB:Q4V925 symbol: bad organism: Danio rerio annotation: acts_upstream_of_or_within GO:0043065 positive regulation of apoptotic process evidence: IGI reference: PMID:20356836 assigned_by: ZFIN node_assessment: node_id: PANTHER:PTN002004007 asserted_term: id: GO:0043065 label: positive regulation of apoptotic process evidence: IRD negated: true seeds: - id: PANTHER:PTN002822469 label: PTN002822469 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:7955 label: Danio rerio - family: PANTHER:PTHR30050 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 8 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P69931 symbol: hda organism: Escherichia coli annotation: located_in GO:0005886 plasma membrane evidence: EXP reference: PMID:12618445 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN001247363 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000769352 label: PTN000769352 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:1236 label: Gammaproteobacteria - family: PANTHER:PTHR30435 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 8 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P0ABW9 symbol: flgB organism: Escherichia coli annotation: located_in GO:0009288 bacterial-type flagellum evidence: IMP reference: PMID:7007337 assigned_by: EcoCyc node_assessment: node_id: PANTHER:PTN004741605 asserted_term: id: GO:0009288 label: bacterial-type flagellum evidence: IRD negated: true seeds: - id: PANTHER:PTN000764839 label: PTN000764839 (ancestral IBD node; IRD source) paint_snapshot: '20240305' - family: PANTHER:PTHR30520 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 37 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P0AC26 symbol: nirC organism: Escherichia coli annotation: enables GO:0015113 nitrite transmembrane transporter activity evidence: EXP reference: PMID:18691156 assigned_by: EcoCyc - protein: UniProtKB:P0AC26 symbol: nirC organism: Escherichia coli annotation: involved_in GO:0015707 nitrite transport evidence: EXP reference: PMID:18691156 assigned_by: EcoCyc node_assessment: node_id: PANTHER:PTN000775620 asserted_term: id: GO:0015707 label: nitrite transport evidence: IRD negated: true seeds: - id: PANTHER:PTN000775604 label: PTN000775604 (ancestral IBD node; IRD source) paint_snapshot: '20240731' node_taxon: id: NCBITaxon:2 label: Bacteria - family: PANTHER:PTHR32494 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 55 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q8VXY9 symbol: UAH organism: Arabidopsis thaliana annotation: acts_upstream_of_or_within GO:0000256 allantoin catabolic process evidence: IDA reference: PMID:19935661 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN001336167 asserted_term: id: GO:0000256 label: allantoin catabolic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000789384 label: PTN000789384 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:33090 label: Viridiplantae - family: PANTHER:PTHR33101 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 68 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q93ZY2 symbol: ROPGEF1 organism: Arabidopsis thaliana annotation: enables GO:0005085 guanyl-nucleotide exchange factor activity evidence: IDA reference: PMID:15980860 assigned_by: TAIR - protein: UniProtKB:Q93ZY2 symbol: ROPGEF1 organism: Arabidopsis thaliana annotation: enables GO:0005085 guanyl-nucleotide exchange factor activity evidence: IMP reference: PMID:28698357 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN002103533 asserted_term: id: GO:0005085 label: guanyl-nucleotide exchange factor activity evidence: IRD negated: true seeds: - id: PANTHER:PTN008650108 label: PTN008650108 (ancestral IBD node; IRD source) paint_snapshot: '20240919' node_taxon: id: NCBITaxon:3398 label: Magnoliopsida - family: PANTHER:PTHR33102 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q7XXN8 symbol: DVL16 organism: Arabidopsis thaliana annotation: located_in GO:0005886 plasma membrane evidence: IDA reference: PMID:15125775 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN002103594 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN002530073 label: PTN002530073 (ancestral IBD node; IRD source) paint_snapshot: '20251024' node_taxon: id: NCBITaxon:3702 label: Arabidopsis thaliana - family: PANTHER:PTHR42884 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 29 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P28840 symbol: Pcsk1 organism: Rattus norvegicus annotation: located_in GO:0005802 trans-Golgi network evidence: IDA reference: PMID:10906712 assigned_by: RGD node_assessment: node_id: PANTHER:PTN001647685 asserted_term: id: GO:0005802 label: trans-Golgi network evidence: IRD negated: true seeds: - id: PANTHER:PTN000082856 label: PTN000082856 (ancestral IBD node; IRD source) paint_snapshot: '20241121' node_taxon: id: NCBITaxon:33213 label: Bilateria - family: PANTHER:PTHR42902 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 15 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:A0A0R4IAX5 symbol: ugl organism: Danio rerio annotation: involved_in GO:0006097 glyoxylate cycle evidence: IDA reference: PMID:37043529 assigned_by: ZFIN node_assessment: node_id: PANTHER:PTN001091897 asserted_term: id: GO:0006097 label: glyoxylate cycle evidence: IRD negated: true seeds: - id: PANTHER:PTN000492975 label: PTN000492975 (ancestral IBD node; IRD source) paint_snapshot: '20260530' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR42923 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 12 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P40012 symbol: HEM14 organism: Saccharomyces cerevisiae annotation: involved_in GO:0006783 heme biosynthetic process evidence: IMP reference: PMID:7035824 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000843445 asserted_term: id: GO:0006783 label: heme biosynthetic process evidence: IRD negated: true seeds: - id: PANTHER:PTN000077911 label: PTN000077911 (ancestral IBD node; IRD source) paint_snapshot: '20250904' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR43003 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:O94468 symbol: mag2 organism: Schizosaccharomyces pombe annotation: involved_in GO:0006285 base-excision repair, AP site formation evidence: IGI reference: PMID:18270439 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN000780612 asserted_term: id: GO:0006285 label: base-excision repair, AP site formation evidence: IRD negated: true seeds: - id: PANTHER:PTN002452908 label: PTN002452908 (ancestral IBD node; IRD source) paint_snapshot: '20211129' node_taxon: id: NCBITaxon:284812 label: Schizosaccharomyces pombe (strain 972 / ATCC 24843) - family: PANTHER:PTHR43081 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P9WQ29 symbol: Rv1320c organism: Mycobacterium tuberculosis annotation: enables GO:0004016 adenylate cyclase activity evidence: IDA reference: PMID:15182360 assigned_by: MTBBASE node_assessment: node_id: PANTHER:PTN002454046 asserted_term: id: GO:0004016 label: adenylate cyclase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002454020 label: PTN002454020 (ancestral IBD node; IRD source) paint_snapshot: '20241203' node_taxon: id: NCBITaxon:83332 label: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - family: PANTHER:PTHR43160 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 14 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P39533 symbol: ACO2 organism: Saccharomyces cerevisiae annotation: involved_in GO:0006099 tricarboxylic acid cycle evidence: IMP reference: PMID:30834327 assigned_by: SGD node_assessment: node_id: PANTHER:PTN000912437 asserted_term: id: GO:0006099 label: tricarboxylic acid cycle evidence: IRD negated: true seeds: - id: PANTHER:PTN000186533 label: PTN000186533 (ancestral IBD node; IRD source) paint_snapshot: '20250904' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR45624 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 35 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q12375 symbol: ORT1 organism: Saccharomyces cerevisiae annotation: enables GO:0000064 L-ornithine transmembrane transporter activity evidence: IDA reference: PMID:9237680 assigned_by: SGD node_assessment: node_id: PANTHER:PTN001183566 asserted_term: id: GO:0000064 label: L-ornithine transmembrane transporter activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000641358 label: PTN000641358 (ancestral IBD node; IRD source) paint_snapshot: '20250904' node_taxon: id: NCBITaxon:4751 label: Fungi - family: PANTHER:PTHR45625 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 105 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9XXI7 symbol: cyn-16 organism: Caenorhabditis elegans annotation: enables GO:0003755 peptidyl-prolyl cis-trans isomerase activity evidence: IDA reference: PMID:11847225 assigned_by: WB node_assessment: node_id: PANTHER:PTN000116766 asserted_term: id: GO:0003755 label: peptidyl-prolyl cis-trans isomerase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN000116298 label: PTN000116298 (ancestral IBD node; IRD source) paint_snapshot: '20240920' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR45740 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 14 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q3UPF5 symbol: Zc3hav1 organism: Mus musculus annotation: located_in GO:0005634 nucleus evidence: EXP reference: PMID:23776219 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002907115 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN005242724 label: PTN005242724 (ancestral IBD node; IRD source) paint_snapshot: '20260530' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR45807 family_has_review: true family_has_paint_tsv: true existing_verdict: LOSS_CONTRADICTED clade_size: 20 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P29597 symbol: TYK2 organism: Homo sapiens annotation: involved_in GO:0007259 cell surface receptor signaling pathway via JAK-STAT evidence: IDA reference: PMID:7526154 assigned_by: UniProt - protein: UniProtKB:P29597 symbol: TYK2 organism: Homo sapiens annotation: involved_in GO:0007259 cell surface receptor signaling pathway via JAK-STAT evidence: IDA reference: PMID:7657660 assigned_by: UniProt - protein: UniProtKB:P29597 symbol: TYK2 organism: Homo sapiens annotation: involved_in GO:0007259 cell surface receptor signaling pathway via JAK-STAT evidence: IDA reference: PMID:8232552 assigned_by: UniProt - protein: UniProtKB:P29597 symbol: TYK2 organism: Homo sapiens annotation: involved_in GO:0007259 cell surface receptor signaling pathway via JAK-STAT evidence: IDA reference: PMID:8605876 assigned_by: UniProt - protein: UniProtKB:P29597 symbol: TYK2 organism: Homo sapiens annotation: involved_in GO:0007259 cell surface receptor signaling pathway via JAK-STAT evidence: IDA reference: PMID:9516124 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN002910252 asserted_term: id: GO:0007259 label: cell surface receptor signaling pathway via JAK-STAT evidence: IRD negated: true seeds: - id: PANTHER:PTN001562978 label: PTN001562978 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR45899 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 21 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q8R5G7 symbol: Arap3 organism: Mus musculus annotation: enables GO:0005096 GTPase activator activity evidence: IDA reference: PMID:15546919 assigned_by: MGI node_assessment: node_id: PANTHER:PTN002913718 asserted_term: id: GO:0005096 label: GTPase activator activity evidence: IRD negated: true seeds: - id: PANTHER:PTN001903126 label: PTN001903126 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR46708 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 21 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q80YX1 symbol: Tnc organism: Mus musculus annotation: acts_upstream_of_or_within GO:0014012 peripheral nervous system axon regeneration evidence: IMP reference: PMID:16262655 assigned_by: MGI - protein: UniProtKB:Q80YX1 symbol: Tnc organism: Mus musculus annotation: involved_in GO:0014012 peripheral nervous system axon regeneration evidence: IMP reference: PMID:16262655 assigned_by: ComplexPortal node_assessment: node_id: PANTHER:PTN008214573 asserted_term: id: GO:0031175 label: neuron projection development evidence: IRD negated: true seeds: - id: PANTHER:PTN002928464 label: PTN002928464 (ancestral IBD node; IRD source) paint_snapshot: '20260530' node_taxon: id: NCBITaxon:32524 label: Amniota - family: PANTHER:PTHR48024 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 104 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q9ASP6 symbol: LIF2 organism: Arabidopsis thaliana annotation: located_in GO:0005634 nucleus evidence: IDA reference: PMID:21304947 assigned_by: UniProt - protein: UniProtKB:Q9FZ84 symbol: RBG6 organism: Arabidopsis thaliana annotation: located_in GO:0005634 nucleus evidence: HDA reference: PMID:28887381 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN008729262 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN002690849 label: PTN002690849 (ancestral IBD node; IRD source) paint_snapshot: '20250904' node_taxon: id: NCBITaxon:3193 label: Embryophyta - family: PANTHER:PTHR48043 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P36537 symbol: UGT2B10 organism: Homo sapiens annotation: enables GO:0015020 glucuronosyltransferase activity evidence: IDA reference: PMID:17576790 assigned_by: UniProt - protein: UniProtKB:P36537 symbol: UGT2B10 organism: Homo sapiens annotation: enables GO:0015020 glucuronosyltransferase activity evidence: IDA reference: PMID:18238858 assigned_by: UniProt - protein: UniProtKB:P36537 symbol: UGT2B10 organism: Homo sapiens annotation: enables GO:0015020 glucuronosyltransferase activity evidence: IDA reference: PMID:28803208 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002484655 asserted_term: id: GO:0015020 label: glucuronosyltransferase activity evidence: IRD negated: true seeds: - id: PANTHER:PTN002629957 label: PTN002629957 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:9606 label: Homo sapiens - family: PANTHER:PTHR48099 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 20 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:Q3V3R1 symbol: Mthfd1l organism: Mus musculus annotation: involved_in GO:0035999 tetrahydrofolate interconversion evidence: IMP reference: PMID:23267094 assigned_by: MGI - protein: UniProtKB:Q3V3R1 symbol: Mthfd1l organism: Mus musculus annotation: involved_in GO:0035999 tetrahydrofolate interconversion evidence: IMP reference: PMID:23267094 assigned_by: MGI node_assessment: node_id: PANTHER:PTN002878462 asserted_term: id: GO:0035999 label: tetrahydrofolate interconversion evidence: IRD negated: true seeds: - id: PANTHER:PTN000002250 label: PTN000002250 (ancestral IBD node; IRD source) paint_snapshot: '20250413' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR48112 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 22 proteins_with_low_throughput_positive: 1 conflicting_experimental_annotations: - protein: UniProtKB:P40630 symbol: Tfam organism: Mus musculus annotation: located_in GO:0005634 nucleus evidence: EXP reference: PMID:8673128 assigned_by: UniProt - protein: UniProtKB:Q00059 symbol: TFAM organism: Homo sapiens annotation: located_in GO:0005634 nucleus evidence: HDA reference: PMID:21630459 assigned_by: UniProt node_assessment: node_id: PANTHER:PTN002927195 asserted_term: id: GO:0005634 label: nucleus evidence: IRD negated: true seeds: - id: PANTHER:PTN008733575 label: PTN008733575 (ancestral IBD node; IRD source) paint_snapshot: '20260601' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR10681 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 80 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q96291 symbol: BAS1 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: HDA reference: PMID:28887381 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000074060 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000073874 label: PTN000073874 (ancestral IBD node; IRD source) paint_snapshot: '20251218' node_taxon: id: NCBITaxon:33090 label: Viridiplantae - family: PANTHER:PTHR10744 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 107 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:P16180 symbol: RPS17 organism: Arabidopsis thaliana annotation: located_in GO:0005739 mitochondrion evidence: HDA reference: PMID:28887381 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000843983 asserted_term: id: GO:0005739 label: mitochondrion evidence: IRD negated: true seeds: - id: PANTHER:PTN000078631 label: PTN000078631 (ancestral IBD node; IRD source) paint_snapshot: '20260528' node_taxon: id: NCBITaxon:3193 label: Embryophyta - family: PANTHER:PTHR11461 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 27 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:P50454 symbol: SERPINH1 organism: Homo sapiens annotation: colocalizes_with GO:0031012 extracellular matrix evidence: HDA reference: PMID:28327460 assigned_by: BHF-UCL - protein: UniProtKB:P50454 symbol: SERPINH1 organism: Homo sapiens annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:25037231 assigned_by: BHF-UCL - protein: UniProtKB:P50454 symbol: SERPINH1 organism: Homo sapiens annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:28675934 assigned_by: BHF-UCL - protein: UniProtKB:P19324 symbol: Serpinh1 organism: Mus musculus annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:22159717 assigned_by: BHF-UCL - protein: UniProtKB:P19324 symbol: Serpinh1 organism: Mus musculus annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:22159717 assigned_by: BHF-UCL - protein: UniProtKB:P19324 symbol: Serpinh1 organism: Mus musculus annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:28071719 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002606963 asserted_term: id: GO:0005576 label: extracellular region evidence: IRD negated: true seeds: - id: PANTHER:PTN000156123 label: PTN000156123 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR11759 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q9CAX6 symbol: RPS14B organism: Arabidopsis thaliana annotation: part_of GO:0022627 cytosolic small ribosomal subunit evidence: HDA reference: PMID:17934214 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000204977 asserted_term: id: GO:0022627 label: cytosolic small ribosomal subunit evidence: IRD negated: true seeds: - id: PANTHER:PTN000204886 label: PTN000204886 (ancestral IBD node; IRD source) paint_snapshot: '20250902' node_taxon: id: NCBITaxon:3702 label: Arabidopsis thaliana - family: PANTHER:PTHR11773 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 127 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q94B78 symbol: GLDP1 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: HDA reference: PMID:25293756 assigned_by: TAIR - protein: UniProtKB:O80988 symbol: GLDP2 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: HDA reference: PMID:25293756 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000206533 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000206531 label: PTN000206531 (ancestral IBD node; IRD source) paint_snapshot: '20170228' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR11994 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 4 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:P42794 symbol: RPL11D organism: Arabidopsis thaliana annotation: part_of GO:0022625 cytosolic large ribosomal subunit evidence: HDA reference: PMID:17934214 assigned_by: TAIR - protein: UniProtKB:P42794 symbol: RPL11D organism: Arabidopsis thaliana annotation: part_of GO:0022625 cytosolic large ribosomal subunit evidence: HDA reference: PMID:17934214 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN004331700 asserted_term: id: GO:0022625 label: cytosolic large ribosomal subunit evidence: IRD negated: true seeds: - id: PANTHER:PTN000242048 label: PTN000242048 (ancestral IBD node; IRD source) paint_snapshot: '20250411' node_taxon: id: NCBITaxon:3700 label: Brassicaceae - family: PANTHER:PTHR21087 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 134 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q9LW20 symbol: SKL1 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: HDA reference: PMID:28887381 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN001078563 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000472457 label: PTN000472457 (ancestral IBD node; IRD source) paint_snapshot: '20181004' node_taxon: id: NCBITaxon:3193 label: Embryophyta - family: PANTHER:PTHR21327 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 15 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q9P7M9 symbol: rib1 organism: Schizosaccharomyces pombe annotation: is_active_in GO:0005829 cytosol evidence: HDA reference: PMID:16823372 assigned_by: PomBase node_assessment: node_id: PANTHER:PTN001084665 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000481609 label: PTN000481609 (ancestral IBD node; IRD source) paint_snapshot: '20181004' node_taxon: id: NCBITaxon:451864 label: Dikarya - family: PANTHER:PTHR22589 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 17 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q8BGD5 symbol: Cpt1c organism: Mus musculus annotation: located_in GO:0005739 mitochondrion evidence: HDA reference: PMID:18614015 assigned_by: MGI node_assessment: node_id: PANTHER:PTN008579947 asserted_term: id: GO:0005739 label: mitochondrion evidence: IRD negated: true seeds: - id: PANTHER:PTN001097100 label: PTN001097100 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:32523 label: Tetrapoda - family: PANTHER:PTHR23152 family_has_review: false family_has_paint_tsv: true existing_verdict: null clade_size: 193 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:F4IWV2 symbol: At3g55410 organism: Arabidopsis thaliana annotation: located_in GO:0005829 cytosol evidence: HDA reference: PMID:28887381 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN000568260 asserted_term: id: GO:0005829 label: cytosol evidence: IRD negated: true seeds: - id: PANTHER:PTN000568360 label: PTN000568360 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:2759 label: Eukaryota - family: PANTHER:PTHR24023 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 18 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q9Y215 symbol: COLQ organism: Homo sapiens annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:25037231 assigned_by: BHF-UCL - protein: UniProtKB:O35348 symbol: Colq organism: Mus musculus annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:22159717 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002771221 asserted_term: id: GO:0031012 label: extracellular matrix evidence: IRD negated: true seeds: - id: PANTHER:PTN008390299 label: PTN008390299 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:117571 label: Euteleostomi - family: PANTHER:PTHR24033 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 1 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q13753 symbol: LAMC2 organism: Homo sapiens annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:25037231 assigned_by: BHF-UCL - protein: UniProtKB:Q13753 symbol: LAMC2 organism: Homo sapiens annotation: located_in GO:0031012 extracellular matrix evidence: HDA reference: PMID:28675934 assigned_by: BHF-UCL node_assessment: node_id: PANTHER:PTN002471704 asserted_term: id: GO:0005576 label: extracellular region evidence: IRD negated: true seeds: - id: PANTHER:PTN008602128 label: PTN008602128 (ancestral IBD node; IRD source) paint_snapshot: '20260529' node_taxon: id: NCBITaxon:9606 label: Homo sapiens - family: PANTHER:PTHR32227 family_has_review: false family_has_paint_tsv: false existing_verdict: null clade_size: 768 proteins_with_low_throughput_positive: 0 conflicting_experimental_annotations: - protein: UniProtKB:Q8VYE5 symbol: At4g29360 organism: Arabidopsis thaliana annotation: located_in GO:0005886 plasma membrane evidence: HDA reference: PMID:14517339 assigned_by: TAIR - protein: UniProtKB:Q9FJU9 symbol: At5g56590 organism: Arabidopsis thaliana annotation: located_in GO:0005886 plasma membrane evidence: HDA reference: PMID:14517339 assigned_by: TAIR - protein: UniProtKB:Q9FJU9 symbol: At5g56590 organism: Arabidopsis thaliana annotation: located_in GO:0005886 plasma membrane evidence: HDA reference: PMID:17644812 assigned_by: TAIR node_assessment: node_id: PANTHER:PTN001283298 asserted_term: id: GO:0005886 label: plasma membrane evidence: IRD negated: true seeds: - id: PANTHER:PTN000796383 label: PTN000796383 (ancestral IBD node; IRD source) paint_snapshot: '20260828' node_taxon: id: NCBITaxon:3193 label: Embryophyta