Ent-kaurene oxidation to kaurenoic acid: obsoletion

GO:0010241 → GO:0009686 gibberellin biosynthetic process (BP) · GO:0052615 ent-kaurene oxidase activity (MF)

AI Gene Review · projects/KAURENE_OXIDATION_OBSOLETION · 2026

Bottom line

  • GO obsoleted GO:0010241, a process term that restated what one enzyme, ent-kaurene oxidase, does.
  • 2 experimental rows were affected: Arabidopsis KO (IMP) remaps to GO:0009686; rice CYP701A6 (IDA, enzyme assay) is removed. UniProt and TAIR have both done this upstream.
  • Scoped, not yet started: no repo review exists for either gene; the open item is the IPR044225 InterPro2GO mapping.

Old term → replacements

What the term described

Why the term went

  • The definition covers three oxidations that "may be carried out entirely by the enzyme ent-kaurene oxidase".
  • That catalytic content already has an MF: GO:0052615 (EC 1.14.14.86), untouched by the obsoletion.
  • The process context is GO:0009686 gibberellin biosynthetic process.
  • SJM on go-annotation#6433: the rice paper (PMID:22487175) has only enzyme assays, so its BP row should simply go.

Affected annotations

Gene Species Evidence PMID Upstream plan Repo review
KO / GA3 (Q93ZB2) A. thaliana IMP 9671797 remap to GO:0009686 none
CYP701A6 (Q5Z5R4) O. sativa Japonica IDA 22487175 remove none

Mapping: InterPro2GO IPR044225 (Ent-kaurene oxidase, chloroplastic) → GO:0010241. Proposed redirect: GO:0052615, since the family is defined by catalytic activity; GO:0009686 would also be defensible.

Status and next steps

  • 2026-05-27: project created; UniProt and TAIR marked DONE upstream.
  • 2026-09-26: OLS lists GO:0010241 as obsolete.
  • Next: comment on the IPR044225 redirect; optionally review Arabidopsis KO as a positive control for the GO:0009686 + GO:0052615 pairing.

Upstream: go-annotation#6433 · go-ontology#32078
Read more: projects/KAURENE_OXIDATION_OBSOLETION.md