KW-1110 → GO remapping

"Inhibition of host TRAFs by virus": tracking an upstream keyword-to-GO change

AI Gene Review · projects/KW_1110_TRAF_KW2GO · 2026

Bottom line

  • KW-1110 was mapped to GO:0039527, now obsolete: "TRAF-mediated signal transduction" is not one pathway.
  • The mapping now points to GO:0140476 (suppression of host cytoplasmic PRR signaling via TRAF inhibition), matching parent keyword KW-1113.
  • Zero gene reviews in this repo carry either term or the keyword. Upstream has shipped; nothing to rework.

Why the old term went

Old term → new terms

Status

  • Created 2026-07-04 as a watch-list entry (blocker: GO:0140476 not yet minted).
  • 2026-09-26: OLS resolves GO:0140476; GO:0039527 obsolete; uniprotkb_kw2go (2026/07/06) maps KW-1110 → GO:0140476.
  • Re-ran grep for GO:0039527, GO:0140476, KW-1110 in genes/: no matches.
  • If a TRAF-interfering effector is reviewed later: use GO:0140476 for RLR evidence, GO:0140470 for TLR evidence.

Upstream: go-annotation#6470 · go-ontology#29238 · Read more: projects/KW_1110_TRAF_KW2GO.md