# Expected protein ligands per pathway term, by lineage (vertebrate symbols are matched
# case-insensitively in human, mouse, rat and zebrafish; fly symbols in Drosophila).
# Used by scripts/triage.py when no other species passes the term.
# Manual judgement (Claude Code, Oct 2026). This is the prior knowledge that should move
# into curated modules: each entry is a candidate ligand step.
expected_ligands:
  vertebrate:
  - term: GO:0036337
    name: Fas signaling pathway
    expected_ligands:
    - FASLG
  - term: GO:0038109
    name: Kit signaling pathway
    expected_ligands:
    - KITLG
  - term: GO:0061314
    name: Notch signaling involved in heart development
    expected_ligands:
    - DLL4
    - JAG1
  - term: GO:0031635
    name: adenylate cyclase-inhibiting opioid receptor signaling pathway
    expected_ligands:
    - PENK
    - PDYN
    - POMC
  - term: GO:0038027
    name: apolipoprotein A-I-mediated signaling pathway
    expected_ligands:
    - APOA1
  - term: GO:0031989
    name: bombesin receptor signaling pathway
    expected_ligands:
    - GRP
    - NMB
  - term: GO:0038115
    name: chemokine (C-C motif) ligand 19 signaling pathway
    expected_ligands:
    - CCL19
  - term: GO:0038065
    name: collagen-activated signaling pathway
    expected_ligands:
    - COL1A1
    - COL4A2
  - term: GO:0038063
    name: collagen-activated tyrosine kinase receptor signaling pathway
    expected_ligands:
    - COL1A1
    - COL1A2
    - COL2A1
    - COL3A1
    - COL4A2
  - term: GO:0038178
    name: complement component C5a signaling pathway
    expected_ligands:
    - C5
  - term: GO:1902178
    name: fibroblast growth factor receptor apoptotic signaling pathway
    expected_ligands:
    - FGF2
    - FGF8
  - term: GO:0035602
    name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic
      process in bone marrow cell
    expected_ligands:
    - FGF10
    - FGF2
    - FGF8
  - term: GO:0090663
    name: galanin-activated signaling pathway
    expected_ligands:
    - GAL
    - GALP
  - term: GO:0038114
    name: interleukin-21-mediated signaling pathway
    expected_ligands:
    - IL21
  - term: GO:0140865
    name: interleukin-22-mediated signaling pathway
    expected_ligands:
    - IL22
  - term: GO:0061514
    name: interleukin-34-mediated signaling pathway
    expected_ligands:
    - IL34
  - term: GO:0038112
    name: interleukin-8-mediated signaling pathway
    expected_ligands:
    - CXCL8
  - term: GO:0035691
    name: macrophage migration inhibitory factor signaling pathway
    expected_ligands:
    - MIF
  - term: GO:0038007
    name: netrin-activated signaling pathway
    # NTN4 (PTHR10574:SF282) is excluded: it is a basement-membrane laminin-network
    # assembly factor that binds laminin gamma1 rather than canonical netrin receptors
    # (DCC, neogenin, UNC5) and sits outside PAINT node PTN008501429 (PMID:25826105).
    expected_ligands:
    - NTN1
    - NTN3
  - term: GO:0086097
    name: phospholipase C-activating angiotensin-activated signaling pathway
    expected_ligands:
    - AGT
  - term: GO:0160135
    name: phospholipase C-activating endothelin receptor signaling pathway
    expected_ligands:
    - EDN1
    - EDN2
    - EDN3
  - term: GO:0090080
    name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
    expected_ligands:
    - FGF23
    - FGF21
    - FGF19
    - FGF15
  - term: GO:0021910
    name: smoothened signaling pathway involved in ventral spinal cord patterning
    expected_ligands:
    - SHH
  - term: GO:0038194
    name: thyroid-stimulating hormone signaling pathway
    expected_ligands:
    - TSHB
    - CGA
  - term: GO:0036323
    name: vascular endothelial growth factor receptor-1 signaling pathway
    expected_ligands:
    - VEGFA
    - VEGFB
    - PGF
  - term: GO:0036325
    name: vascular endothelial growth factor receptor-3 signaling pathway
    expected_ligands:
    - VEGFC
    - VEGFD
  fly:
  - term: GO:0140709
    name: Frizzled Nuclear Import pathway
    expected_ligands:
    - wg
  - term: GO:0035385
    name: Roundabout signaling pathway
    expected_ligands:
    - sli
  - term: GO:0038063
    name: collagen-activated tyrosine kinase receptor signaling pathway
    expected_ligands:
    - Col4a1
    - vkg
  - term: GO:0048013
    name: ephrin receptor signaling pathway
    expected_ligands:
    - Ephrin
  - term: GO:0097191
    name: extrinsic apoptotic signaling pathway
    expected_ligands:
    - egr
  - term: GO:0048009
    name: insulin-like growth factor receptor signaling pathway
    expected_ligands:
    - Ilp2
    - Ilp3
    - Ilp5
  - term: GO:0038007
    name: netrin-activated signaling pathway
    expected_ligands:
    - NetA
    - NetB
  - term: GO:0038179
    name: neurotrophin signaling pathway
    expected_ligands:
    - spz5
    - NT1
    - spz