# Curator labels for pathway terms that are not expected to contain a host protein ligand.
# X = ligand is a small molecule, light or a microbial product.
# Y = antigen, immunoglobulin, cell contact, or ligand-independent signaling.
# Used by scripts/triage.py; terms listed here are not looked up for a missing ligand.
# Manual judgement (Claude Code, Oct 2026); review before relying on it.
term_labels:
- term: GO:0098990
  name: AMPA selective glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0001973
  name: G protein-coupled adenosine receptor signaling pathway
  category: X
  reason: adenosine
- term: GO:0007212
  name: G protein-coupled dopamine receptor signaling pathway
  category: X
  reason: dopamine
- term: GO:0007216
  name: G protein-coupled glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0016056
  name: G protein-coupled opsin signaling pathway
  category: X
  reason: light (opsin)
- term: GO:0035589
  name: G protein-coupled purinergic nucleotide receptor signaling pathway
  category: X
  reason: nucleotides
- term: GO:1904068
  name: G protein-coupled receptor signaling pathway involved in social behavior
  category: X
  reason: octopamine (fly Oamb is the sole failing annotation; generic GPCR behavior term)
- term: GO:0098664
  name: G protein-coupled serotonin receptor signaling pathway
  category: X
  reason: serotonin
- term: GO:0098989
  name: NMDA selective glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0035665
  name: TIRAP-dependent toll-like receptor 4 signaling pathway
  category: X
  reason: LPS
- term: GO:0035669
  name: TRAM-dependent toll-like receptor 4 signaling pathway
  category: X
  reason: LPS
- term: GO:0035667
  name: TRIF-dependent toll-like receptor 4 signaling pathway
  category: X
  reason: LPS
- term: GO:0038184
  name: adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
  category: X
  reason: bile acids
- term: GO:0071880
  name: adenylate cyclase-activating adrenergic receptor signaling pathway
  category: X
  reason: adrenaline/noradrenaline
- term: GO:0007191
  name: adenylate cyclase-activating dopamine receptor signaling pathway
  category: X
  reason: dopamine
- term: GO:0010619
  name: adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
  category: X
  reason: glucose
- term: GO:0007192
  name: adenylate cyclase-activating serotonin receptor signaling pathway
  category: X
  reason: serotonin
- term: GO:0007197
  name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
  category: X
  reason: acetylcholine
- term: GO:0007196
  name: adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0071881
  name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway
  category: X
  reason: adrenaline/noradrenaline
- term: GO:0007195
  name: adenylate cyclase-inhibiting dopamine receptor signaling pathway
  category: X
  reason: dopamine
- term: GO:0007198
  name: adenylate cyclase-inhibiting serotonin receptor signaling pathway
  category: X
  reason: serotonin
- term: GO:0071875
  name: adrenergic receptor signaling pathway
  category: X
  reason: adrenaline/noradrenaline
- term: GO:0160213
  name: beta-arrestin-dependent dopamine receptor signaling pathway
  category: X
  reason: dopamine
- term: GO:0038171
  name: cannabinoid signaling pathway
  category: X
  reason: cannabinoids
- term: GO:0002752
  name: cell surface pattern recognition receptor signaling pathway
  category: X
  reason: microbial products
- term: GO:0140895
  name: cell surface toll-like receptor signaling pathway
  category: X
  reason: microbial products
- term: GO:0099565
  name: chemical synaptic transmission, postsynaptic
  category: X
  reason: neurotransmitters
- term: GO:0071926
  name: endocannabinoid signaling pathway
  category: X
  reason: endocannabinoids
- term: GO:0007215
  name: glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0035235
  name: ionotropic glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0061737
  name: leukotriene signaling pathway
  category: X
  reason: leukotrienes
- term: GO:0007211
  name: octopamine or tyramine signaling pathway
  category: X
  reason: octopamine/tyramine
- term: GO:0007207
  name: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
  category: X
  reason: acetylcholine
- term: GO:0007206
  name: phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
  category: X
  reason: glutamate
- term: GO:0071882
  name: phospholipase C-activating adrenergic receptor signaling pathway
  category: X
  reason: adrenaline/noradrenaline
- term: GO:0060158
  name: phospholipase C-activating dopamine receptor signaling pathway
  category: X
  reason: dopamine
- term: GO:0030265
  name: phospholipase C-activating opsin-mediated signaling pathway
  category: X
  reason: light (opsin)
- term: GO:0007208
  name: phospholipase C-activating serotonin receptor signaling pathway
  category: X
  reason: serotonin
- term: GO:0035590
  name: purinergic nucleotide receptor signaling pathway
  category: X
  reason: nucleotides
- term: GO:0003376
  name: sphingosine-1-phosphate receptor signaling pathway
  category: X
  reason: sphingosine-1-phosphate
- term: GO:0002223
  name: stimulatory C-type lectin receptor signaling pathway
  category: X
  reason: beta-glucan
- term: GO:0038193
  name: thromboxane A2 signaling pathway
  category: X
  reason: thromboxane A2
- term: GO:0034134
  name: toll-like receptor 2 signaling pathway
  category: X
  reason: lipopeptides
- term: GO:0034142
  name: toll-like receptor 4 signaling pathway
  category: X
  reason: LPS
- term: GO:0034146
  name: toll-like receptor 5 signaling pathway
  category: X
  reason: flagellin
- term: GO:0141190
  name: transducin-mediated opsin signaling pathway
  category: X
  reason: light (opsin)
- term: GO:0071928
  name: tyramine signaling pathway
  category: X
  reason: tyramine
- term: GO:0050853
  name: B cell receptor signaling pathway
  category: Y
  reason: antigen
- term: GO:0002774
  name: Fc receptor mediated inhibitory signaling pathway
  category: Y
  reason: immunoglobulin
- term: GO:0038093
  name: Fc receptor signaling pathway
  category: Y
  reason: antigen/immunoglobulin
- term: GO:0038095
  name: Fc-epsilon receptor signaling pathway
  category: Y
  reason: IgE/antigen
- term: GO:0038094
  name: Fc-gamma receptor signaling pathway
  category: Y
  reason: antigen/immunoglobulin
- term: GO:0086103
  name: G protein-coupled receptor signaling pathway involved in heart process
  category: Y
  reason: generic GPCR term qualified by heart process
- term: GO:0160221
  name: Rho-activating G protein-coupled receptor signaling pathway
  category: Y
  reason: adhesion GPCRs with tethered agonists among annotated genes
- term: GO:0050852
  name: T cell receptor signaling pathway
  category: Y
  reason: antigen/immunoglobulin
- term: GO:0060071
  name: Wnt signaling pathway, planar cell polarity pathway
  category: Y
  reason: core PCP is ligand-independent
- term: GO:0007185
  name: cell surface receptor protein tyrosine phosphatase signaling pathway
  category: Y
  reason: contact/unknown
- term: GO:0097192
  name: extrinsic apoptotic signaling pathway in absence of ligand
  category: Y
  reason: ligand withdrawal by definition
- term: GO:0002767
  name: immune response-inhibiting cell surface receptor signaling pathway
  category: Y
  reason: various immune ligands incl. MHC
- term: GO:0002768
  name: immune response-regulating cell surface receptor signaling pathway
  category: Y
  reason: antigen/immunoglobulin
- term: GO:0007229
  name: integrin-mediated signaling pathway
  category: Y
  reason: ECM/cell contact
- term: GO:0038035
  name: ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway
  category: Y
  reason: ligand-independent by definition
- term: GO:0002769
  name: natural killer cell inhibitory signaling pathway
  category: Y
  reason: MHC class I
- term: GO:0030845
  name: phospholipase C-inhibiting G protein-coupled receptor signaling pathway
  category: Y
  reason: generic GPCR effector term
- term: GO:0002222
  name: stimulatory killer cell immunoglobulin-like receptor signaling pathway
  category: Y
  reason: MHC class I