accession	symbol	length	class	protein_existence	annotation_score	created	signal_peptide	transmembrane	protein_name	n_annotations	n_informative	n_exp	n_iba	n_iea	n_other	only_protein_binding_or_root	exp_aspects	has_MF	has_BP	has_CC	go_terms	exp_go_terms	function_cc
P0DOY5	IGHD1-1	5	Ig/TCR gene segment	Predicted	2.0	2017-03-15	0	0	Immunoglobulin heavy diversity 1-1	6	6	0	0	2	4	0		0	0	1	GO:0005576;GO:0005886		D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane
A0A0C4DH62	IGHJ1	17	Ig/TCR gene segment	Predicted	2.0	2017-03-15	0	0	Immunoglobulin heavy joining 1	6	6	0	0	2	4	0		0	0	1	GO:0005576;GO:0005886		J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane
A0A0A0MT89	IGKJ1	12	Ig/TCR gene segment	Predicted	2.0	2017-03-15	0	0	Immunoglobulin kappa joining 1	6	6	0	0	2	4	0		0	0	1	GO:0005576;GO:0005886		J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the me
A0A0A0MT76	IGLJ1	42	Ig/TCR gene segment	Predicted	2.0	2017-03-15	0	0	Immunoglobulin lambda joining 1	6	6	0	0	2	4	0		0	0	1	GO:0005576;GO:0005886		J region of the variable domain of immunoglobulin lambda light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the m
A0A075B6Y3	TRAJ3	20	Ig/TCR gene segment	Predicted	2.0	2018-07-18	0	0	T cell receptor alpha joining 3	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pe
A0A075B700	TRAJ31	18	Ig/TCR gene segment	Predicted	1.0	2020-06-17	0	0	T cell receptor alpha joining 31	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A075B6Y9	TRAJ42	20	Ig/TCR gene segment	Predicted	2.0	2019-05-08	0	0	T cell receptor alpha joining 42	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pe
P0DPI4	TRBD1	4	Ig/TCR gene segment	Predicted	2.0	2018-07-18	0	0	T cell receptor beta diversity 1	2	2	0	0	1	1	0		0	0	1	GO:0005886		D region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0J9YXA8	TRBJ1-1	15	Ig/TCR gene segment	Predicted	1.0	2018-07-18	0	0	T cell receptor beta joining 1-1	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0J9YX06	TRBJ1-2	15	Ig/TCR gene segment	Evidence at protein level	2.0	2019-07-03	0	0	T cell receptor beta joining 1-2	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0J9YWP8	TRBJ1-3	16	Ig/TCR gene segment	Predicted	1.0	2019-05-08	0	0	T cell receptor beta joining 1-3	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0J9YXG5	TRBJ1-4	16	Ig/TCR gene segment	Predicted	1.0	2019-05-08	0	0	T cell receptor beta joining 1-4	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0J9YXM7	TRBJ1-5	16	Ig/TCR gene segment	Predicted	1.0	2019-05-08	0	0	T cell receptor beta joining 1-5	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0J9YWX3	TRBJ1-6	17	Ig/TCR gene segment	Predicted	2.0	2019-05-08	0	0	T cell receptor beta joining 1-6	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0A0MTA7	TRBJ2-1	16	Ig/TCR gene segment	Predicted	2.0	2019-05-08	0	0	T cell receptor beta joining 2-1	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0A0MT94	TRBJ2-2	16	Ig/TCR gene segment	Predicted	1.0	2019-06-05	0	0	T cell receptor beta joining 2-2	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0B4J200	TRBJ2-3	16	Ig/TCR gene segment	Evidence at protein level	2.0	2019-06-05	0	0	T cell receptor beta joining 2-3	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0A0MT87	TRBJ2-4	16	Ig/TCR gene segment	Predicted	1.0	2019-06-05	0	0	T cell receptor beta joining 2-4	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0A0MTA4	TRBJ2-5	15	Ig/TCR gene segment	Predicted	1.0	2019-06-05	0	0	T cell receptor beta joining 2-5	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0A0MT70	TRBJ2-6	17	Ig/TCR gene segment	Predicted	2.0	2019-06-05	0	0	T cell receptor beta joining 2-6	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
A0A0A0MT78	TRBJ2-7	15	Ig/TCR gene segment	Predicted	2.0	2019-05-08	0	0	T cell receptor beta joining 2-7	2	2	0	0	1	1	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pep
P0DPR3	TRDD1	2	Ig/TCR gene segment	Evidence at protein level	2.0	2018-12-05	0	0	T cell receptor delta diversity 1	1	1	0	0	1	0	0		0	0	1	GO:0005886		D region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment
A0A075B706	TRDJ1	16	Ig/TCR gene segment	Evidence at protein level	2.0	2018-12-05	0	0	T cell receptor delta joining 1	1	1	0	0	1	0	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment
A2JGV3	TRGC1	58	Ig/TCR gene segment	Evidence at protein level	1.0	2023-02-22	0	0	T-cell receptor gamma alternate reading frame protein (TARP)	0	0	0	0	0	0	0		0	0	0			
A0A075B6S0	TRGJ1	16	Ig/TCR gene segment	Evidence at protein level	2.0	2019-01-16	0	0	T cell receptor gamma joining 1	1	1	0	0	1	0	0		0	0	1	GO:0005886		J region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment
P56381	ATP5F1E	51	OXPHOS subunit	Evidence at protein level	5.0	1998-07-15	0	0	ATP synthase F(1) complex subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon)	29	25	5	3	8	9	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0005759;GO:0015986;GO:0042776;GO:0045259;GO:0046933	mitochondrion [GO:0005739, HTP]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776, IDA]; proton-transporting ATP synthase complex [GO:0045259, IDA]; proton-transporting ATP synthase complex [GO:0045259, IMP]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933, IDA]	Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase com
Q5VTU8	ATP5F1EP2	51	OXPHOS subunit	Evidence at protein level	3.0	2008-09-02	0	0	ATP synthase subunit epsilon-like protein, mitochondrial (ATP synthase F1 subunit epsilon pseudogene 2)	15	15	1	3	7	4	0	C	1	1	1	GO:0005739;GO:0005743;GO:0015986;GO:0042776;GO:0045259;GO:0046933	mitochondrion [GO:0005739, HDA]	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the
P56385	ATP5ME	69	OXPHOS subunit	Evidence at protein level	5.0	1998-07-15	0	0	ATP synthase F(0) complex subunit e, mitochondrial (ATPase subunit e) (ATP synthase membrane subunit e) [Cleaved into: ATP synthase F(0) complex subunit e, mitochondrial, N-terminally processed]	29	25	5	4	8	8	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0015078;GO:0015986;GO:0016020;GO:0042776;GO:0044877;GO:0045259;GO:0046933;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776, IDA]; proton-transporting ATP synthase complex [GO:0045259, IDA]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933, IDA]	Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex c
P56134	ATP5MF	94	OXPHOS subunit	Evidence at protein level	5.0	1997-11-01	0	1	ATP synthase F(0) complex subunit f, mitochondrial (ATP synthase membrane subunit f)	20	20	5	3	2	10	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0015986;GO:0042776;GO:0045259;GO:0046933;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776, IDA]; proton-transporting ATP synthase complex [GO:0045259, IDA]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933, IDA]	Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex c
Q7Z4Y8	ATP5MGL	100	OXPHOS subunit	Evidence at protein level	3.0	2006-03-07	0	0	ATP synthase subunit g 2, mitochondrial (ATPase subunit g 2) (ATP synthase membrane subunit g-like protein)	11	11	1	3	4	3	0	C	1	1	1	GO:0005739;GO:0005743;GO:0015078;GO:0015986;GO:0031966;GO:0045259;GO:0046933;GO:1902600	mitochondrion [GO:0005739, HTP]	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the
P56378	ATP5MJ	58	OXPHOS subunit	Evidence at protein level	5.0	1998-07-15	0	1	ATP synthase F(0) complex subunit j, mitochondrial (6.8 kDa mitochondrial proteolipid protein) (MLQ) (ATP synthase membrane subunit 6.8PL)	17	14	3	1	2	8	0	C	0	1	1	GO:0005739;GO:0005743;GO:0015986;GO:0031966;GO:0045259	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial membrane [GO:0031966, EXP]	Subunit j, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex c
Q96IX5	ATP5MK	58	OXPHOS subunit	Evidence at protein level	5.0	2006-04-04	0	1	ATP synthase F(0) complex subunit k, mitochondrial (ATP synthase membrane subunit DAPIT, mitochondrial) (Diabetes-associated protein in insulin-sensitive tissues) (HCV F-transactivated protein 2) (Up-regulated during skeletal muscle growth protein 5)	17	17	6	1	2	8	0	C	0	1	1	GO:0005739;GO:0005743;GO:0015986;GO:0031966;GO:0045259	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrion [GO:0005739, IMP]; mitochondrial membrane [GO:0031966, EXP]; proton-transporting ATP synthase complex [GO:0045259, IMP]	Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist 
Q9NYJ1	COA4	87	OXPHOS subunit	Evidence at protein level	4.0	2008-01-15	0	0	Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8) (E2-induced gene 2 protein)	8	7	2	1	4	0	0	C	0	1	1	GO:0005739;GO:0005758;GO:0033617	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	Putative COX assembly factor. {ECO:0000250}.
Q86WW8	COA5	74	OXPHOS subunit	Evidence at protein level	4.0	2008-03-18	0	0	Cytochrome c oxidase assembly factor 5	12	8	2	2	1	3	0	C	0	1	1	GO:0005739;GO:0005743;GO:0005758;GO:0033617	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	Assembly factor for cytochrome c oxidase (respiratory chain complex IV) (PubMed:21457908, PubMed:35750769). Stabilizes an early formation of cytochrome c oxidase assembly factors, until it is displaced by the metallochaperone copper-delivery protein COX17 (PubMed:35750769). {ECO:0000269|PubMed:21457
Q96I36	COX14	57	OXPHOS subunit	Evidence at protein level	5.0	2006-12-12	0	1	Cytochrome c oxidase assembly protein COX14	19	18	8	2	2	6	0	CFP	1	1	1	GO:0005739;GO:0005741;GO:0005743;GO:0006457;GO:0033617;GO:0044183	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial outer membrane [GO:0005741, IDA]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IMP]; protein folding chaperone [GO:0044183, IDA]	Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. {ECO:0000269|Pu
Q14061	COX17	63	OXPHOS subunit	Evidence at protein level	5.0	1997-11-01	0	0	Cytochrome c oxidase copper chaperone	33	26	7	3	11	5	0	CFP	1	1	1	GO:0005507;GO:0005737;GO:0005739;GO:0005758;GO:0008047;GO:0016531;GO:0033617;GO:1903136	cytoplasm [GO:0005737, IDA]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial intermembrane space [GO:0005758, IDA]; copper chaperone activity [GO:0016531, IMP]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IMP]; cuprous ion binding [GO:1903136, IDA]	Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:15229189, PubMed:19393246, PubMed:31903891, PubMed:35750769). Binds two copper ions and delivers them to metallochaperones SCO1 and SCO2, which co-chaperone the copper ions to the Cu(
Q49B96	COX19	90	OXPHOS subunit	Evidence at protein level	5.0	2007-01-23	0	0	Cytochrome c oxidase assembly protein COX19 (hCOX19)	23	22	12	2	5	3	0	CFP	1	1	1	GO:0005739;GO:0005758;GO:0005829;GO:0006457;GO:0006878;GO:0033617;GO:0044183;GO:0051604	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial intermembrane space [GO:0005758, IDA]; cytosol [GO:0005829, IDA]; intracellular copper ion homeostasis [GO:0006878, IMP]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IDA]; protein folding chaperone [GO:0044183, IDA]; protein maturation [GO:0051604, IDA]	Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:35750769). Acts as a COX11 chaperone that supports COX11 copper coordination (PubMed:35750769). Also stimulates SCO2-mediated metalation of COX2 (PubMed:35750769). Required for the transduction of an SCO1-dependent 
Q02221	COX6A2	97	OXPHOS subunit	Evidence at protein level	5.0	1993-07-01	0	1	Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (Cytochrome c oxidase subunit VIA-muscle) (COX VIa-M)	15	15	1	3	6	5	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006091;GO:0006119;GO:0006123;GO:0030234;GO:0045277	mitochondrion [GO:0005739, HTP]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
P14854	COX6B1	86	OXPHOS subunit	Evidence at protein level	5.0	1990-04-01	0	0	Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)	23	23	6	3	8	6	0	CP	1	1	1	GO:0004129;GO:0005739;GO:0005743;GO:0006119;GO:0006123;GO:0021762;GO:0031966;GO:0045277;GO:0045333;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, EXP]; substantia nigra development [GO:0021762, HEP]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
Q6YFQ2	COX6B2	88	OXPHOS subunit	Evidence at protein level	4.0	2005-10-11	0	0	Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)	15	13	2	2	5	4	0	C	0	1	1	GO:0005739;GO:0005743;GO:0006119;GO:0016020;GO:0030061;GO:0045277	mitochondrion [GO:0005739, HTP]; mitochondrial crista [GO:0030061, IDA]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
P09669	COX6C	75	OXPHOS subunit	Evidence at protein level	5.0	1989-07-01	0	1	Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)	24	21	5	1	5	10	0	C	0	1	1	GO:0005739;GO:0005743;GO:0005758;GO:0006091;GO:0006119;GO:0006123;GO:0031966;GO:0045277;GO:0045333	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, EXP]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
P24310	COX7A1	79	OXPHOS subunit	Evidence at protein level	5.0	1992-03-01	0	1	Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)	26	22	1	4	9	8	0	C	1	1	1	GO:0004129;GO:0005739;GO:0005743;GO:0006091;GO:0006119;GO:0006123;GO:0030674;GO:0031966;GO:0045277;GO:0097250;GO:0098803;GO:1902600	mitochondrion [GO:0005739, HTP]	Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (By similarity). The CIV complex is the component of the respiratory chain that catalyzes the red
P14406	COX7A2	83	OXPHOS subunit	Evidence at protein level	5.0	1990-01-01	0	1	Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL)	19	18	4	4	5	5	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006119;GO:0006123;GO:0030674;GO:0031966;GO:0045277;GO:0045333;GO:0098803	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, EXP]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
P24311	COX7B	80	OXPHOS subunit	Evidence at protein level	5.0	1992-03-01	0	1	Cytochrome c oxidase subunit 7B, mitochondrial (Cytochrome c oxidase polypeptide VIIb)	20	19	5	2	5	7	0	CP	1	1	1	GO:0004129;GO:0005739;GO:0005743;GO:0006119;GO:0006123;GO:0007417;GO:0031966;GO:0045277;GO:0045333;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, EXP]; central nervous system development [GO:0007417, IMP]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
Q8TF08	COX7B2	81	OXPHOS subunit	Evidence at protein level	3.0	2004-06-07	0	1	Cytochrome c oxidase subunit 7B2, mitochondrial (Cytochrome c oxidase polypeptide VIIb2)	8	8	1	2	4	1	0	C	0	1	1	GO:0005739;GO:0005743;GO:0006119;GO:0006123;GO:0045277	mitochondrion [GO:0005739, HTP]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
P15954	COX7C	63	OXPHOS subunit	Evidence at protein level	5.0	1990-04-01	0	1	Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc)	24	21	6	1	7	7	0	C	0	1	1	GO:0005739;GO:0005743;GO:0006091;GO:0006119;GO:0006123;GO:0031966;GO:0045277;GO:0045333	mitochondrion [GO:0005739, HDA]; mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, EXP]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex IV [GO:0045277, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
P10176	COX8A	69	OXPHOS subunit	Evidence at protein level	5.0	1989-07-01	0	1	Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver/heart) (Cytochrome c oxidase subunit 8-2)	24	20	4	2	6	8	0	C	1	1	1	GO:0004129;GO:0005739;GO:0005743;GO:0006091;GO:0006119;GO:0006123;GO:0031966;GO:0043403;GO:0045277;GO:0045333;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, EXP]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
Q7Z4L0	COX8C	72	OXPHOS subunit	Evidence at protein level	3.0	2004-01-16	0	1	Cytochrome c oxidase subunit 8C, mitochondrial (Cytochrome c oxidase polypeptide 8 isoform 3) (Cytochrome c oxidase polypeptide VIII isoform 3) (COX VIII-3) (Cytochrome c oxidase subunit 8-3) (COX8-3) (Cytochrome c oxidase subunit VIIIC)	13	13	2	2	4	5	0	C	0	1	1	GO:0005739;GO:0005743;GO:0006119;GO:0006123;GO:0045277	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
O00483	COXFA4	81	OXPHOS subunit	Evidence at protein level	5.0	1997-11-01	0	1	Cytochrome c oxidase subunit FA4 (Complex I-MLRQ) (CI-MLRQ) (Cytochrome c oxidase subunit NDUFA4) (NADH-ubiquinone oxidoreductase MLRQ subunit)	24	21	9	2	2	8	0	CF	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0006123;GO:0008137;GO:0031966;GO:0044877;GO:0045277;GO:0045333;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, EXP]; mitochondrial membrane [GO:0031966, IDA]; protein-containing complex binding [GO:0044877, IDA]; respiratory chain complex IV [GO:0045277, IDA]; respiratory chain complex IV [GO:0045277, IPI]	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 compl
Q9NRX3	COXFA4L2	87	OXPHOS subunit	Evidence at protein level	4.0	2002-09-19	0	1	Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2) (NADH-ubiquinone oxidoreductase MLRQ subunit homolog) (NUOMS)	13	13	7	1	5	0	0	CFP	1	1	1	GO:0001666;GO:0004857;GO:0005739;GO:0005743;GO:0071456;GO:1902957;GO:1903427	response to hypoxia [GO:0001666, IDA]; enzyme inhibitor activity [GO:0004857, IDA]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; cellular response to hypoxia [GO:0071456, IDA]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957, IDA]	Mitochondrial protein that plays a regulatory role in cellular metabolism, particularly under hypoxic conditions (PubMed:22100406). Down-regulates mitochondrial respiratory chain complex I activity under hypoxia, reduces oxygen consumption and ROS and helps cells adapt by switching to glycolysis (Pu
Q9C002	COXFA4L3	83	OXPHOS subunit	Evidence at protein level	4.0	2002-09-19	0	1	Cytochrome c oxidase associated subunit FA4L3 (Modulator of cytochrome C oxidase during inflammation protein) (MOCCI) (Normal mucosa of esophagus-specific gene 1 protein) (NMES1) (Protein FOAP-11)	5	4	2	1	1	0	0	C	0	0	1	GO:0005634;GO:0005739;GO:0005743	nucleus [GO:0005634, IDA]; mitochondrion [GO:0005739, HTP]	Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane p
P03928	MT-ATP8	68	OXPHOS subunit	Evidence at protein level	5.0	1986-07-21	0	1	ATP synthase F(0) complex subunit 8 (A6L) (F-ATPase subunit 8)	22	21	4	3	5	9	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0015078;GO:0015986;GO:0031966;GO:0042776;GO:0045259;GO:0046933;GO:1902600	mitochondrion [GO:0005739, HTP]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776, IDA]; proton-transporting ATP synthase complex [GO:0045259, IDA]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933, IDA]	Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex c
C0HME5	MT-ND4	99	OXPHOS subunit	Evidence at protein level	3.0	2026-01-28	0	0	Mitochondrial alternative ND4 protein (MTALTND4)	3	3	0	0	3	0	0		0	0	1	GO:0005576;GO:0005737;GO:0005739		Regulates mitochondrial respiration by decreasing oxygen consumption (PubMed:37198654). Also regulates reactive oxygen species homeostasis (PubMed:37198654). {ECO:0000269|PubMed:37198654}.
P03901	MT-ND4L	98	OXPHOS subunit	Evidence at protein level	5.0	1986-07-21	0	1	NADH-ubiquinone oxidoreductase chain 4L (EC 7.1.1.2) (NADH dehydrogenase subunit 4L) (ND4L)	26	26	7	1	10	8	0	CF	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0016651;GO:0042773;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; NADH dehydrogenase (ubiquinone) activity [GO:0008137, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:28844695). Part of the enzyme membrane arm which is embedded in the lipid bilayer an
O15239	NDUFA1	70	OXPHOS subunit	Evidence at protein level	5.0	1998-07-15	0	1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit)	27	27	9	1	4	13	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0031966;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ub
O43678	NDUFA2	99	OXPHOS subunit	Evidence at protein level	5.0	1999-07-15	0	0	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit)	28	28	7	1	6	14	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0031966;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial membrane [GO:0031966, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ub
O95167	NDUFA3	84	OXPHOS subunit	Evidence at protein level	5.0	1999-07-15	0	1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit)	41	25	6	1	6	12	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HDA]; mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ub
A1L188	NDUFAF8	74	OXPHOS subunit	Evidence at protein level	4.0	2007-09-11	0	0	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8	14	10	5	2	3	0	0	CP	0	1	1	GO:0005739;GO:0005759;GO:0032981	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial matrix [GO:0005759, IDA]; mitochondrial respiratory chain complex I assembly [GO:0032981, IMP]	Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296). {ECO:0000269|PubMed:27499296}.
O75438	NDUFB1	58	OXPHOS subunit	Evidence at protein level	5.0	1999-07-15	0	1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit)	25	25	6	1	5	13	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubi
O43676	NDUFB3	98	OXPHOS subunit	Evidence at protein level	5.0	1999-07-15	0	1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit)	27	27	5	1	7	14	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0022900;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ub
O43677	NDUFC1	76	OXPHOS subunit	Evidence at protein level	4.0	1999-07-15	0	1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (Complex I-KFYI) (CI-KFYI) (NADH-ubiquinone oxidoreductase KFYI subunit)	27	27	5	1	6	15	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006120;GO:0008137;GO:0009060;GO:0042776;GO:0045271;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex I [GO:0045271, IDA]; respiratory chain complex I [GO:0045271, IPI]	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ub
Q8N5G0	SMIM20	67	OXPHOS subunit	Evidence at protein level	5.0	2008-03-18	0	1	Small integral membrane protein 20 (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa) (MITRAC7) [Cleaved into: Phoenixin-14 (PNX-14); Phoenixin-20 (PNX-20)]	16	15	3	2	4	6	0	CP	0	1	1	GO:0005576;GO:0005739;GO:0005743;GO:0016020;GO:0033617	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IDA]	[Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT
Q6UW78	UQCC3	93	OXPHOS subunit	Evidence at protein level	5.0	2004-11-23	0	1	Ubiquinol-cytochrome-c reductase complex assembly factor 3 (Assembly factor CBP4 homolog)	14	14	9	3	2	0	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0006122;GO:0034551;GO:0042407;GO:0070300;GO:1901612	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122, IMP]; mitochondrial respiratory chain complex III assembly [GO:0034551, IMP]; cristae formation [GO:0042407, IMP]; phosphatidic acid binding [GO:0070300, IDA]; cardiolipin binding [GO:1901612, IDA]	Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Ca
Q8WVI0	UQCC5	70	OXPHOS subunit	Evidence at protein level	4.0	2008-09-02	0	1	Ubiquinol-cytochrome c reductase complex assembly factor 5 (Small integral membrane protein 4)	6	6	4	0	1	1	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0033617;GO:0034551;GO:0097177	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IDA]; mitochondrial ribosome binding [GO:0097177, IDA]	Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (By simi
Q69YU5	UQCC6	71	OXPHOS subunit	Evidence at protein level	4.0	2008-06-10	0	1	Ubiquinol-cytochrome c reductase complex assembly factor 6 (Protein BRAWNIN)	11	10	5	2	2	1	0	CP	0	1	1	GO:0005739;GO:0005743;GO:0033617;GO:0034551	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IDA]; mitochondrial respiratory chain complex III assembly [GO:0034551, IMP]	Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:
Q9UDW1	UQCR10	63	OXPHOS subunit	Evidence at protein level	5.0	2000-12-01	0	1	Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein)	22	21	3	2	8	8	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006122;GO:0008121;GO:0045275;GO:0045333;GO:1902600	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex III [GO:0045275, IPI]	Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol
O14957	UQCR11	56	OXPHOS subunit	Evidence at protein level	5.0	1998-12-15	0	1	Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 6.4 kDa protein)	19	19	3	1	7	8	0	C	1	1	1	GO:0005739;GO:0005743;GO:0006091;GO:0006122;GO:0009055;GO:0045275;GO:0045333	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex III [GO:0045275, IPI]	Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol
P07919	UQCRH	91	OXPHOS subunit	Evidence at protein level	5.0	1988-08-01	0	0	Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)	28	21	5	2	4	10	0	CF	1	1	1	GO:0005739;GO:0005743;GO:0006119;GO:0006122;GO:0008121;GO:0009060;GO:0045275;GO:0045333;GO:0098803;GO:1902600	mitochondrion [GO:0005739, HDA]; mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; quinol-cytochrome-c reductase activity [GO:0008121, IMP]; respiratory chain complex III [GO:0045275, IPI]	Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol
A0A096LP55	UQCRHL	91	OXPHOS subunit	Evidence at protein level	3.0	2016-02-17	0	0	Cytochrome b-c1 complex subunit 6-like, mitochondrial	7	7	1	2	3	1	0	C	0	1	1	GO:0005739;GO:0005743;GO:0006122;GO:0045275	mitochondrion [GO:0005739, HTP]	May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. {ECO:0000250|UniProtKB:P00127}.
O14949	UQCRQ	82	OXPHOS subunit	Evidence at protein level	5.0	1998-07-15	0	1	Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C)	29	29	4	2	15	8	0	C	0	1	1	GO:0005739;GO:0005743;GO:0006122;GO:0021539;GO:0021548;GO:0021680;GO:0021766;GO:0021794;GO:0021854;GO:0021860;GO:0030901;GO:0045275;GO:0045333	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; respiratory chain complex III [GO:0045275, IPI]	Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol
P59990	KRTAP12-1	96	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-11-07	0	0	Keratin-associated protein 12-1 (High sulfur keratin-associated protein 12.1) (Keratin-associated protein 12.1)	67	3	0	0	2	1	0		0	0	1	GO:0005829;GO:0045095		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
P60328	KRTAP12-3	96	keratin-associated / cornified envelope	Evidence at protein level	5.0	2004-02-02	0	0	Keratin-associated protein 12-3 (High sulfur keratin-associated protein 12.3) (Keratin-associated protein 12.3)	140	2	1	0	0	1	0	F	1	0	1	GO:0005829;GO:0042802	identical protein binding [GO:0042802, IPI]	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q8IUB9	KRTAP19-1	90	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-07-03	0	0	Keratin-associated protein 19-1 (High tyrosine-glycine keratin-associated protein 19.1)	50	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LHN2	KRTAP19-2	52	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 19-2	46	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q7Z4W3	KRTAP19-3	81	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 19-3 (GTHRP) (Glycine/tyrosine-rich protein)	19	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI73	KRTAP19-4	84	keratin-associated / cornified envelope	Evidence at protein level	3.0	2006-02-21	0	0	Keratin-associated protein 19-4	6	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI72	KRTAP19-5	72	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 19-5	107	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI70	KRTAP19-6	58	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 19-6	67	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3SYF9	KRTAP19-7	63	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 19-7	97	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI54	KRTAP19-8	63	keratin-associated / cornified envelope	Inferred from homology	2.0	2007-10-23	0	0	Keratin-associated protein 19-8	2	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI63	KRTAP20-1	56	keratin-associated / cornified envelope	Inferred from homology	2.0	2006-02-21	0	0	Keratin-associated protein 20-1	2	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI61	KRTAP20-2	65	keratin-associated / cornified envelope	Evidence at protein level	2.0	2006-02-21	0	0	Keratin-associated protein 20-2	2	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI60	KRTAP20-3	44	keratin-associated / cornified envelope	Inferred from homology	2.0	2007-10-23	0	0	Keratin-associated protein 20-3	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI62	KRTAP20-4	44	keratin-associated / cornified envelope	Inferred from homology	2.0	2007-10-23	0	0	Putative keratin-associated protein 20-4	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI58	KRTAP21-1	79	keratin-associated / cornified envelope	Inferred from homology	2.0	2006-02-21	0	0	Keratin-associated protein 21-1	1	1	0	0	0	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI59	KRTAP21-2	83	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 21-2	30	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LHN1	KRTAP21-3	58	keratin-associated / cornified envelope	Inferred from homology	2.0	2009-10-13	0	0	Keratin-associated protein 21-3	1	1	0	0	0	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3MIV0	KRTAP22-1	48	keratin-associated / cornified envelope	Inferred from homology	2.0	2006-02-21	0	0	Keratin-associated protein 22-1	2	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI68	KRTAP22-2	45	keratin-associated / cornified envelope	Inferred from homology	2.0	2008-05-20	0	0	Keratin-associated protein 22-2	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
A1A580	KRTAP23-1	65	keratin-associated / cornified envelope	Evidence at protein level	3.0	2007-06-12	0	0	Keratin-associated protein 23-1	8	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q9BYR8	KRTAP3-1	98	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-10-10	0	0	Keratin-associated protein 3-1 (High sulfur keratin-associated protein 3.1) (Keratin-associated protein 3.1)	90	4	0	0	3	1	0		1	0	1	GO:0005198;GO:0005829;GO:0045095		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q9BYR7	KRTAP3-2	98	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-10-10	0	0	Keratin-associated protein 3-2 (High sulfur keratin-associated protein 3.2) (Keratin-associated protein 3.2)	90	4	0	0	3	1	0		1	0	1	GO:0005198;GO:0005829;GO:0045095		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q9BYR6	KRTAP3-3	98	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-10-10	0	0	Keratin-associated protein 3-3 (High sulfur keratin-associated protein 3.3) (Keratin-associated protein 3.3)	78	4	0	0	3	1	0		1	0	1	GO:0005198;GO:0005829;GO:0045095		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI64	KRTAP6-1	71	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 6-1	90	3	1	0	1	1	0	C	0	1	1	GO:0005829;GO:0031424	cytosol [GO:0005829, HDA]	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q3LI66	KRTAP6-2	62	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-02-21	0	0	Keratin-associated protein 6-2	183	3	1	0	1	1	0	F	1	1	1	GO:0005829;GO:0031424;GO:0042802	identical protein binding [GO:0042802, IPI]	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q8IUC3	KRTAP7-1	87	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-07-19	0	0	Keratin-associated protein 7-1 (High tyrosine-glycine keratin-associated protein 7.1)	36	0	0	0	0	0	1		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q8IUC2	KRTAP8-1	63	keratin-associated / cornified envelope	Evidence at protein level	5.0	2003-06-27	0	0	Keratin-associated protein 8-1 (High glycine-tyrosine keratin-associated protein 8.1)	100	2	0	0	1	1	0		0	0	1	GO:0005829		In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
Q5TA76	LCE3A	89	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-05-16	0	0	Late cornified envelope protein 3A (Late envelope protein 13)	65	4	3	0	1	0	0	P	0	1	0	GO:0008544;GO:0031640;GO:0050829;GO:0050830	killing of cells of another organism [GO:0031640, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]	A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, ma
Q5TA77	LCE3B	95	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-05-16	0	0	Late cornified envelope protein 3B (Late envelope protein 14)	43	4	3	0	1	0	0	P	0	1	0	GO:0008544;GO:0031640;GO:0050829;GO:0050830	killing of cells of another organism [GO:0031640, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]	A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, ma
Q5T5A8	LCE3C	94	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-05-16	0	0	Late cornified envelope protein 3C (Late envelope protein 15) (Small proline-rich-like epidermal differentiation complex protein 3A)	64	4	3	0	1	0	0	P	0	1	0	GO:0008544;GO:0031640;GO:0050829;GO:0050830	killing of cells of another organism [GO:0031640, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]	A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, ma
Q9BYE3	LCE3D	92	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-05-16	0	0	Late cornified envelope protein 3D (Late envelope protein 16) (Small proline-rich-like epidermal differentiation complex protein 6A) (Small proline-rich-like epidermal differentiation complex protein 6B)	54	4	0	0	1	3	0		0	1	1	GO:0005829;GO:0008544		Precursors of the cornified envelope of the stratum corneum.
Q5T5B0	LCE3E	92	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-05-16	0	0	Late cornified envelope protein 3E (Late envelope protein 17)	63	1	0	0	1	0	0		0	1	0	GO:0008544		Precursors of the cornified envelope of the stratum corneum.
Q5TA78	LCE4A	99	keratin-associated / cornified envelope	Evidence at protein level	5.0	2006-05-16	0	0	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A)	84	2	1	0	1	0	0	F	1	1	0	GO:0008544;GO:0042802	identical protein binding [GO:0042802, IPI]	Precursors of the cornified envelope of the stratum corneum.
A0A183	LCE6A	80	keratin-associated / cornified envelope	Evidence at protein level	2.0	2008-01-15	0	0	Late cornified envelope protein 6A	0	0	0	0	0	0	0		0	0	0			Precursors of the cornified envelope of the stratum corneum. {ECO:0000250}.
P0DV60	LCE7A	95	keratin-associated / cornified envelope	Inferred from homology	1.0	2022-02-23	0	0	Late cornified envelope protein 7A	1	1	0	0	1	0	0		0	1	0	GO:0008544		Precursors of the cornified envelope of the stratum corneum. {ECO:0000250|UniProtKB:Q5TA76}.
P35321	SPRR1A	89	keratin-associated / cornified envelope	Evidence at protein level	5.0	1994-02-01	0	0	Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA)	18	16	6	0	1	9	0	CFP	1	1	1	GO:0001533;GO:0005198;GO:0005737;GO:0005829;GO:0008544;GO:0018149;GO:0030216;GO:0030280;GO:0070268	cornified envelope [GO:0001533, IDA]; peptide cross-linking [GO:0018149, IDA]; keratinocyte differentiation [GO:0030216, IDA]; structural constituent of skin epidermis [GO:0030280, IDA]; cornification [GO:0070268, IDA]	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
P22528	SPRR1B	89	keratin-associated / cornified envelope	Evidence at protein level	5.0	1991-08-01	0	0	Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB)	14	14	3	0	1	10	0	CP	1	1	1	GO:0001533;GO:0005198;GO:0005737;GO:0005829;GO:0008544;GO:0018149;GO:0030216	cornified envelope [GO:0001533, IDA]; peptide cross-linking [GO:0018149, IDA]; keratinocyte differentiation [GO:0030216, IDA]	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as b
P35326	SPRR2A	72	keratin-associated / cornified envelope	Evidence at protein level	5.0	1994-02-01	0	0	Small proline-rich protein 2A (SPR-2A) (2-1)	19	18	6	0	4	8	0	CFP	1	1	1	GO:0001533;GO:0005576;GO:0005737;GO:0005829;GO:0008289;GO:0019731;GO:0030133;GO:0030141;GO:0048874;GO:0050830	extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, IDA]; lipid binding [GO:0008289, IDA]; antibacterial humoral response [GO:0019731, IDA]; secretory granule [GO:0030141, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]	Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidi
P35325	SPRR2B	72	keratin-associated / cornified envelope	Evidence at transcript level	4.0	1994-02-01	0	0	Small proline-rich protein 2B (SPR-2B)	13	13	0	0	3	10	0		0	1	1	GO:0001533;GO:0005737;GO:0005829;GO:0008544;GO:0030216		Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
P22532	SPRR2D	72	keratin-associated / cornified envelope	Evidence at protein level	4.0	1991-08-01	0	0	Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II)	13	13	2	0	3	8	0	C	0	1	1	GO:0001533;GO:0005737;GO:0005829;GO:0008544	cytoplasm [GO:0005737, IDA]	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
P22531	SPRR2E	72	keratin-associated / cornified envelope	Evidence at transcript level	4.0	1991-08-01	0	0	Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II)	20	19	7	0	3	9	0	CFP	1	1	1	GO:0001533;GO:0005198;GO:0005737;GO:0005829;GO:0008544;GO:0030280;GO:0070268	cornified envelope [GO:0001533, IDA]; cytoplasm [GO:0005737, IDA]; structural constituent of skin epidermis [GO:0030280, IDA]; cornification [GO:0070268, IDA]	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Q96RM1	SPRR2F	72	keratin-associated / cornified envelope	Evidence at protein level	3.0	2004-03-15	0	0	Small proline-rich protein 2F (SPR-2F)	13	13	0	0	3	10	0		0	1	1	GO:0001533;GO:0005737;GO:0005829;GO:0008544;GO:0030216		Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {
Q9BYE4	SPRR2G	73	keratin-associated / cornified envelope	Evidence at protein level	3.0	2004-03-15	0	0	Small proline-rich protein 2G (SPR-2G)	13	13	0	0	3	10	0		0	1	1	GO:0001533;GO:0005737;GO:0005829;GO:0008544;GO:0030216		Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {
Q96PI1	SPRR4	79	keratin-associated / cornified envelope	Evidence at protein level	3.0	2003-10-10	0	0	Small proline-rich protein 4	3	3	1	0	2	0	0	C	0	0	1	GO:0005737;GO:0005829;GO:0005938	cytosol [GO:0005829, IDA]	Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.
P04731	MT1A	61	metallothionein	Evidence at protein level	5.0	1987-08-13	0	0	Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)	19	17	2	8	1	6	0	P	1	1	1	GO:0005634;GO:0005737;GO:0005829;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	cellular response to cadmium ion [GO:0071276, IEP]; cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P07438	MT1B	61	metallothionein	Evidence at protein level	5.0	1988-04-01	0	0	Metallothionein-1B (MT-1B) (Metallothionein-IB) (MT-IB)	19	14	1	8	1	4	0	P	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
A1L3X4	MT1DP	49	metallothionein	Uncertain	3.0	2008-07-01	0	0	Putative metallothionein MT1DP	12	9	0	8	1	0	0		1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0010273;GO:0046872;GO:0071276;GO:0071280;GO:0071294		Metallothioneins have a high content of cysteine residues that bind various heavy metals. {ECO:0000250}.
P04732	MT1E	61	metallothionein	Evidence at protein level	5.0	1987-08-13	0	0	Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE)	17	16	5	8	1	2	0	CP	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cellular response to cadmium ion [GO:0071276, IEP]; cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P04733	MT1F	61	metallothionein	Evidence at protein level	5.0	1987-08-13	0	0	Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF)	16	15	3	8	1	3	0	CP	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cellular response to cadmium ion [GO:0071276, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P13640	MT1G	62	metallothionein	Evidence at protein level	5.0	1990-01-01	0	0	Metallothionein-1G (MT-1G) (Metallothionein-1K) (MT-1K) (Metallothionein-IG) (MT-IG)	28	26	15	8	1	2	0	CFP	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0030224;GO:0035924;GO:0042117;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; zinc ion binding [GO:0008270, IDA]; cellular response to vascular endothelial growth factor stimulus [GO:0035924, IEP]; negative regulation of growth [GO:0045926, IDA]; cellular response to cadmium ion [GO:0071276, IEP]; cellular response to copper ion [GO:0071280, IEP]; cellular response to zinc ion [GO:0071294, IDA]; cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P80294	MT1H	61	metallothionein	Evidence at protein level	5.0	1994-02-01	0	0	Metallothionein-1H (MT-1H) (Metallothionein-0) (MT-0) (Metallothionein-IH) (MT-IH)	19	16	3	8	1	4	0	P	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	cellular response to cadmium ion [GO:0071276, IEP]; cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P0DM35	MT1HL1	61	metallothionein	Evidence at protein level	3.0	2013-05-29	0	0	Metallothionein 1H-like protein 1	9	9	0	8	1	0	0		1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0010273;GO:0046872;GO:0071276;GO:0071280;GO:0071294		Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. {ECO:0000250}.
Q93083	MT1L	61	metallothionein	Evidence at protein level	3.0	1997-11-01	0	0	Metallothionein-1L (MT-1L) (Metallothionein-IL) (MT-IL)	14	14	1	8	1	4	0	P	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. {ECO:0000250}.
Q8N339	MT1M	61	metallothionein	Evidence at protein level	5.0	2006-02-07	0	0	Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM)	20	14	0	8	1	5	0		1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010273;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294		Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P80297	MT1X	61	metallothionein	Evidence at protein level	5.0	1994-02-01	0	0	Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX)	21	18	5	8	1	4	0	CP	1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0008270;GO:0010038;GO:0010273;GO:0036018;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cellular response to erythropoietin [GO:0036018, IEP]; cellular response to cadmium ion [GO:0071276, IEP]; cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525). {ECO:0000269|PubMed:23251525}.
P02795	MT2A	61	metallothionein	Evidence at protein level	5.0	1986-07-21	0	0	Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)	36	20	3	8	1	8	0	P	1	1	1	GO:0005634;GO:0005737;GO:0005829;GO:0006878;GO:0006882;GO:0008270;GO:0010273;GO:0036016;GO:0036018;GO:0045926;GO:0046872;GO:0071276;GO:0071280;GO:0071294	cellular response to interleukin-3 [GO:0036016, IEP]; cellular response to erythropoietin [GO:0036018, IEP]; cellular response to zinc ion [GO:0071294, IEP]	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
P25713	MT3	68	metallothionein	Evidence at protein level	5.0	1992-05-01	0	0	Metallothionein-3 (MT-3) (GIFB) (GIF) (Growth inhibitory factor) (Metallothionein-III) (MT-III)	75	72	29	9	22	12	0	CFP	1	1	1	GO:0001666;GO:0001934;GO:0005507;GO:0005576;GO:0005634;GO:0005737;GO:0005741;GO:0005829;GO:0005840;GO:0005874;GO:0006829;GO:0006882;GO:0006979;GO:0008021;GO:0008270;GO:0010273;GO:0010628;GO:0010977;GO:0016209;GO:0016234;GO:0019430;GO:0030003;GO:0030295;GO:0030308;GO:0030424;GO:0030517;GO:0030949;GO:0032148;GO:0034599;GO:0034614;GO:0043066;GO:0043197;GO:0043524;GO:0045893;GO:0046870;GO:0046872;GO:0048471;GO:0050821;GO:0051354;GO:0070374;GO:0071276;GO:0071280;GO:0071294;GO:0071456;GO:0071585;GO:0097449;GO:0097450;GO:1990748;GO:2000296	response to hypoxia [GO:0001666, IDA]; positive regulation of protein phosphorylation [GO:0001934, IDA]; copper ion binding [GO:0005507, IDA]; cytoplasm [GO:0005737, IDA]; zinc ion binding [GO:0008270, IDA]; positive regulation of gene expression [GO:0010628, IDA]; inclusion body [GO:0016234, IDA]; removal of superoxide radicals [GO:0019430, IDA]; protein kinase activator activity [GO:0030295, IDA]; negative regulation of cell growth [GO:0030308, IDA]; negative regulation of cell growth [GO:0030308, IMP]; negative regulation of axon extension [GO:0030517, IDA]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949, IDA]; activation of protein kinase B activity [GO:0032148, IDA]; cellular response to oxidative stress [GO:0034599, IEP]; cellular response to reactive oxygen species [GO:0034614, IDA]; positive regulation of DNA-templated transcription [GO:0045893, IDA]; cadmium ion binding [GO:0046870, IDA]; perinuclear region of cytoplasm [GO:0048471, IDA]; protein stabilization [GO:0050821, IDA]; negative regulation of oxidoreductase activity [GO:0051354, IDA]; positive regulation of ERK1 and ERK2 cascade [GO:0070374, IDA]; cellular response to hypoxia [GO:0071456, IEP]; cellular detoxification [GO:1990748, IDA]	Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
P47944	MT4	62	metallothionein	Evidence at protein level	3.0	1996-02-01	0	0	Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV)	10	10	0	8	2	0	0		1	1	1	GO:0005634;GO:0005737;GO:0006882;GO:0010273;GO:0046872;GO:0071276;GO:0071280;GO:0071294		Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
A0A0C5B5G6	MT-RNR1	16	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at protein level	5.0	2016-04-13	0	0	Mitochondrial-derived peptide MOTS-c (Mitochondrial open reading frame of the 12S rRNA-c)	21	20	17	0	3	0	0	CFP	1	1	1	GO:0001649;GO:0003677;GO:0005576;GO:0005634;GO:0005739;GO:0006357;GO:0032147;GO:0033687;GO:0043610;GO:0048630;GO:0071902;GO:0072522;GO:0140297;GO:2001145	osteoblast differentiation [GO:0001649, IDA]; DNA binding [GO:0003677, IDA]; extracellular region [GO:0005576, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; mitochondrion [GO:0005739, IDA]; regulation of transcription by RNA polymerase II [GO:0006357, IDA]; activation of protein kinase activity [GO:0032147, IDA]; osteoblast proliferation [GO:0033687, IDA]; regulation of carbohydrate utilization [GO:0043610, IDA]; skeletal muscle tissue growth [GO:0048630, IDA]; positive regulation of protein serine/threonine kinase activity [GO:0071902, IDA]; purine-containing compound biosynthetic process [GO:0072522, IDA]; DNA-binding transcription factor binding [GO:0140297, IPI]; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:2001145, IDA]	Regulates insulin sensitivity and metabolic homeostasis (PubMed:25738459, PubMed:33468709). Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation o
Q8IVG9	MT-RNR2	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at protein level	5.0	2004-09-27	0	0	Humanin (Humanin mitochondrial) (HNM)	77	64	47	2	5	10	0	CFP	1	1	1	GO:0001664;GO:0005102;GO:0005576;GO:0005634;GO:0005737;GO:0005739;GO:0006879;GO:0007005;GO:0007267;GO:0030595;GO:0031514;GO:0032692;GO:0032701;GO:0036126;GO:0042802;GO:0043066;GO:0043524;GO:0048018;GO:0048019;GO:0048471;GO:0050728;GO:0097225;GO:0097435;GO:0097696;GO:0150079;GO:1900118;GO:1900226;GO:1902883;GO:1904646;GO:1905907	G protein-coupled receptor binding [GO:0001664, IPI]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, EXP]; cytoplasm [GO:0005737, IDA]; mitochondrion [GO:0005739, IDA]; mitochondrion organization [GO:0007005, IDA]; cell-cell signaling [GO:0007267, IDA]; leukocyte chemotaxis [GO:0030595, IDA]; negative regulation of interleukin-1 production [GO:0032692, IDA]; negative regulation of interleukin-18 production [GO:0032701, IDA]; sperm flagellum [GO:0036126, IDA]; identical protein binding [GO:0042802, IPI]; negative regulation of apoptotic process [GO:0043066, IDA]; negative regulation of neuron apoptotic process [GO:0043524, IDA]; receptor ligand activity [GO:0048018, IDA]; receptor antagonist activity [GO:0048019, IDA]; perinuclear region of cytoplasm [GO:0048471, IDA]; negative regulation of inflammatory response [GO:0050728, IDA]; sperm midpiece [GO:0097225, IDA]; supramolecular fiber organization [GO:0097435, IDA]; cell surface receptor signaling pathway via STAT [GO:0097696, IDA]; negative regulation of neuroinflammatory response [GO:0150079, IDA]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226, IDA]; negative regulation of response to oxidative stress [GO:1902883, IDA]; cellular response to amyloid-beta [GO:1904646, IDA]; negative regulation of amyloid fibril formation [GO:1905907, IDA]	Plays a role as a neuroprotective factor (PubMed:11371646, PubMed:11717357, PubMed:12154011, PubMed:12787071, PubMed:12860203, PubMed:19386761). Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:
A0A3G1DIU6	MT-RNR2	26	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at protein level	3.0	2026-01-28	0	0	Small humanin-like peptide 2 (SHLP2)	4	4	2	0	2	0	0	C	0	0	1	GO:0005576;GO:0005743	extracellular region [GO:0005576, EXP]; mitochondrial inner membrane [GO:0005743, EXP]	Binds to and activates chemokine receptor ACKR3/CXCR7 which results in activation of proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus, leading to suppression of food intake and increased energy expenditure (PubMed:37468558). Displays chaperone-like activity, inhibiting misfoldi
A0A3G1DJK2	MT-RNR2	26	mtDNA-rRNA-encoded peptide (humanin-like)	Predicted	2.0	2026-01-28	0	0	Small humanin-like peptide 4 (SHLP4)	0	0	0	0	0	0	0		0	0	0			Promotes cell proliferation in vitro. {ECO:0000269|PubMed:27070352}.
A0A3G1DJQ2	MT-RNR2	38	mtDNA-rRNA-encoded peptide (humanin-like)	Predicted	2.0	2026-01-28	0	0	Small humanin-like peptide 3 (SHLP3)	0	0	0	0	0	0	0		0	0	0			Significantly reduces apoptosis and the generation of reactive oxygen species and improves mitochondrial metabolism in vitro (PubMed:27070352). Reduces gentamicin-induced cochlear hair cell loss in vitro by decreasing activation of AKT and AMPK alpha as well as reducing oxidative stress and decreasi
A0A3G1DJN1	MT-RNR2	20	mtDNA-rRNA-encoded peptide (humanin-like)	Predicted	2.0	2026-01-28	0	0	Small humanin-like peptide 6 (SHLP6)	0	0	0	0	0	0	0		0	0	0			Significantly increases apoptosis in vitro. {ECO:0000269|PubMed:27070352}.
A0A3G1DJL1	MT-RNR2	24	mtDNA-rRNA-encoded peptide (humanin-like)	Predicted	1.0	2026-01-28	0	0	Small humanin-like peptide 5 (SHLP5)	1	1	0	0	1	0	0		1	0	0	GO:0016714		
A0A3G1DJL7	MT-RNR2	24	mtDNA-rRNA-encoded peptide (humanin-like)	Predicted	1.0	2026-01-28	0	0	Small humanin-like peptide 1 (SHLP1)	0	0	0	0	0	0	0		0	0	0			
P0CJ68	MTRNR2L1	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 1 (HN1) (MT-RNR2-like protein 1)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ77	MTRNR2L10	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 10 (HN10) (MT-RNR2-like protein 10)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
S4R3Y5	MTRNR2L11	24	mtDNA-rRNA-encoded peptide (humanin-like)	Inferred from homology	2.0	2014-11-26	0	0	Humanin-like 11 (HN11) (MT-RNR2-like protein 11)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0DMP1	MTRNR2L12	24	mtDNA-rRNA-encoded peptide (humanin-like)	Inferred from homology	2.0	2014-10-01	0	0	Humanin-like 12 (HN12) (MT-RNR2-like protein 12)	4	4	0	0	2	2	0		0	0	1	GO:0005576;GO:0005737		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
S4R3P1	MTRNR2L13	24	mtDNA-rRNA-encoded peptide (humanin-like)	Inferred from homology	2.0	2014-10-01	0	0	Humanin-like 13 (HN13) (MT-RNR2-like protein 13)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ69	MTRNR2L2	28	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 2 (HN2) (MT-RNR2-like protein 2)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ70	MTRNR2L3	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 3 (HN3) (MT-RNR2-like protein 3)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ71	MTRNR2L4	28	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 4 (HN4) (MT-RNR2-like protein 4)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ72	MTRNR2L5	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	3.0	2011-02-08	0	0	Humanin-like 5 (HN5) (MT-RNR2-like protein 5)	9	9	3	2	2	2	0	P	1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:0072734;GO:1900118;GO:1902109	cellular response to staurosporine [GO:0072734, IMP]; negative regulation of execution phase of apoptosis [GO:1900118, IMP]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109, IMP]	Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9, ECO:0000269|PubMed:19477263}.
P0CJ73	MTRNR2L6	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 6 (HN6) (MT-RNR2-like protein 6)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ74	MTRNR2L7	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 7 (HN7) (MT-RNR2-like protein 7)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ75	MTRNR2L8	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 8 (HN8) (MT-RNR2-like protein 8)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
P0CJ76	MTRNR2L9	24	mtDNA-rRNA-encoded peptide (humanin-like)	Evidence at transcript level	2.0	2011-02-08	0	0	Humanin-like 9 (HN9) (MT-RNR2-like protein 9)	6	6	0	2	2	2	0		1	1	1	GO:0005576;GO:0005737;GO:0048019;GO:1900118		Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9}.
Q9P1F3	ABRACL	81	other characterized small protein	Evidence at protein level	3.0	2003-11-07	0	0	Costars family protein ABRACL (ABRA C-terminal-like protein)	3	3	0	1	2	0	0		0	1	1	GO:0005929;GO:0030027;GO:0032970		Associates with the actin cytoskeleton and may modulate actin dynamics, in favor of increasing the relative content of F-actin, therefore may play a role in cell migration. May be acting by inhibiting CFL1-mediated actin depolymerization. {ECO:0000269|PubMed:33670794}.
Q8N6N7	ACBD7	88	other characterized small protein	Evidence at protein level	3.0	2006-07-25	0	0	Acyl-CoA-binding domain-containing protein 7	5	3	0	2	1	0	0		1	1	0	GO:0000062;GO:0006631		Binds medium- and long-chain acyl-CoA esters.
P07311	ACYP1	99	other characterized small protein	Evidence at protein level	4.0	1988-04-01	0	0	Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)	6	6	0	1	3	2	0		1	1	0	GO:0003998;GO:0006796		
P14621	ACYP2	99	other characterized small protein	Evidence at protein level	5.0	1990-04-01	0	0	Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)	12	10	4	1	3	2	0	CF	1	1	1	GO:0003998;GO:0005739;GO:0006796;GO:0042802	acylphosphatase activity [GO:0003998, IDA]; mitochondrion [GO:0005739, HTP]; identical protein binding [GO:0042802, IPI]	catalyzes the hydrolysis of acylphosphates compounds containing a carboxylphosphate bond. {ECO:0000269|PubMed:8268218}.
Q0VDE8	ADIG	80	other characterized small protein	Inferred from homology	3.0	2007-07-24	0	1	Adipogenin	16	16	0	5	2	9	0		0	1	1	GO:0005634;GO:0005737;GO:0005789;GO:0005811;GO:0019915;GO:0045444;GO:0045600;GO:0050872;GO:0050873;GO:0140042		Key regulator of lipid storage that promotes the expansion of lipid droplets during the formation of mature adipocytes. Acts by forming a dodecameric complex with seipin (BSCL2) when adipocytes have differentiated and are undergoing maturation. In the dodecameric complex, ADIG antagonizes the activi
Q15847	ADIRF	76	other characterized small protein	Evidence at protein level	4.0	2000-12-01	0	0	Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2)	12	11	6	2	3	0	0	CP	0	1	1	GO:0005634;GO:0005654;GO:0045600;GO:0045944;GO:0070062	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; positive regulation of fat cell differentiation [GO:0045600, IDA]; positive regulation of transcription by RNA polymerase II [GO:0045944, IDA]; extracellular exosome [GO:0070062, HDA]	Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplat
P0CW23	AKAIN1	69	other characterized small protein	Evidence at protein level	4.0	2011-06-28	0	0	A-kinase anchor protein inhibitor 1	6	5	2	0	3	0	0	FP	1	1	1	GO:0005829;GO:0008104;GO:0051018	intracellular protein localization [GO:0008104, IDA]; protein kinase A binding [GO:0051018, IDA]	Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177). {ECO:0000269|PubMed:25653177}.
Q9BSF0	AKAP19	95	other characterized small protein	Evidence at protein level	5.0	2008-09-02	0	0	A-kinase anchoring protein 19 (Small membrane A-kinase anchor protein) (Small membrane AKAP) (smAKAP)	13	4	2	0	2	0	0	C	1	0	1	GO:0005886;GO:0034237	plasma membrane [GO:0005886, EXP]; plasma membrane [GO:0005886, IDA]	Binds to type I regulatory subunits of protein kinase A (PKA-RI) and anchors/targets them to the plasma membrane. {ECO:0000269|PubMed:23115245, ECO:0000269|PubMed:27028580}.
Q9NYG5	ANAPC11	84	other characterized small protein	Evidence at protein level	5.0	2001-08-29	0	0	Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)	109	79	19	7	12	41	0	CFP	1	1	1	GO:0000278;GO:0001664;GO:0004842;GO:0005634;GO:0005654;GO:0005680;GO:0005730;GO:0005737;GO:0005829;GO:0006511;GO:0007346;GO:0008270;GO:0016567;GO:0031145;GO:0031461;GO:0034450;GO:0043161;GO:0045842;GO:0051445;GO:0061630;GO:0070936;GO:0070979;GO:0097602;GO:0141198	ubiquitin-protein transferase activity [GO:0004842, IDA]; nucleoplasm [GO:0005654, IDA]; anaphase-promoting complex [GO:0005680, IDA]; anaphase-promoting complex [GO:0005680, IPI]; nucleolus [GO:0005730, IDA]; protein ubiquitination [GO:0016567, IDA]; anaphase-promoting complex-dependent catabolic process [GO:0031145, IDA]; ubiquitin-ubiquitin ligase activity [GO:0034450, IDA]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842, IDA]; ubiquitin protein ligase activity [GO:0061630, IDA]; protein K48-linked ubiquitination [GO:0070936, IDA]; protein K11-linked ubiquitination [GO:0070979, IDA]; cullin family protein binding [GO:0097602, IDA]; protein branched polyubiquitination [GO:0141198, IDA]	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:11739784, PubMed:18485873, PubMed:27120157, PubMed:27509861). Together with ANAPC2, forms the catalytic component of the E3 ubiquitin lig
Q9BS18	ANAPC13	74	other characterized small protein	Evidence at protein level	5.0	2006-10-17	0	0	Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)	23	16	7	2	3	4	0	CP	0	1	1	GO:0005634;GO:0005680;GO:0007346;GO:0016567;GO:0031145;GO:0051445;GO:0070936;GO:0070979;GO:0141198	anaphase-promoting complex [GO:0005680, IDA]; anaphase-promoting complex [GO:0005680, IPI]; anaphase-promoting complex-dependent catabolic process [GO:0031145, IDA]; protein K48-linked ubiquitination [GO:0070936, IDA]; protein K11-linked ubiquitination [GO:0070979, IDA]; protein branched polyubiquitination [GO:0141198, IDA]	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:15060174, PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target
Q8WVX3	ARLN	66	other characterized small protein	Evidence at protein level	5.0	2008-03-18	0	1	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN (SERCA regulator ARLN) (Allregulin) (Another-regulin) (ALN) (Hepatitis C virus F protein-transactivated protein 1) (HCV F-transactivated protein 1)	62	3	0	0	2	1	0		0	0	1	GO:0005789		Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+). {ECO:0000250|UniProtKB:Q99M08}.
O00244	ATOX1	68	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	0	Copper transport protein ATOX1 (Metal transport protein ATX1)	29	19	5	3	5	6	0	F	1	1	1	GO:0005507;GO:0005829;GO:0006825;GO:0006878;GO:0006979;GO:0016530;GO:0016531;GO:0032767;GO:0043066;GO:0046872;GO:0051117;GO:0060003;GO:1903136	copper ion binding [GO:0005507, IDA]; copper chaperone activity [GO:0016531, IDA]; copper-dependent protein binding [GO:0032767, IDA]; copper-dependent protein binding [GO:0032767, IPI]; cuprous ion binding [GO:1903136, IDA]	Multifunctional copper-sensing protein that operates both as a cytosolic copper chaperone and as a copper-dependent transcription factor. Essential for maintaining cellular copper homeostasis and linking copper distribution to redox balance, signal transduction, and gene regulation. In the cytosol, 
O15342	ATP6V0E1	81	other characterized small protein	Evidence at protein level	5.0	1998-07-15	0	1	V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1)	42	26	2	2	4	18	0	FP	1	1	1	GO:0000220;GO:0005765;GO:0007035;GO:0010008;GO:0016020;GO:0016241;GO:0030670;GO:0033179;GO:0042625;GO:0046961;GO:1902600	proton-transporting ATPase activity, rotational mechanism [GO:0046961, IGI]; proton transmembrane transport [GO:1902600, IGI]	Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellula
Q8NHE4	ATP6V0E2	81	other characterized small protein	Evidence at protein level	5.0	2007-01-09	0	1	V-type proton ATPase subunit e 2 (V-ATPase subunit e 2) (Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2) (Vacuolar proton pump subunit e 2)	29	29	2	3	7	17	0	FP	1	1	1	GO:0000220;GO:0005765;GO:0007035;GO:0010008;GO:0016020;GO:0016241;GO:0030665;GO:0030670;GO:0030672;GO:0033179;GO:0042625;GO:0046961;GO:1902600	proton-transporting ATPase activity, rotational mechanism [GO:0046961, IGI]; proton transmembrane transport [GO:1902600, IGI]	Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular 
Q96GX2	ATXN7L3B	97	other characterized small protein	Evidence at protein level	4.0	2010-03-23	0	0	Ataxin-7-like protein 3B	6	4	2	1	1	0	0	CP	0	1	1	GO:0005737;GO:0010468	cytoplasm [GO:0005737, IDA]; regulation of gene expression [GO:0010468, IEP]	By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of 
Q156A1	ATXN8	80	other characterized small protein	Evidence at protein level	2.0	2007-01-09	0	0	Ataxin-8 (Protein 1C2)	1	1	0	0	1	0	0		0	0	1	GO:0005634		
O75531	BANF1	89	other characterized small protein	Evidence at protein level	5.0	1999-07-15	0	0	Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]	96	61	30	4	8	19	0	CFP	1	1	1	GO:0000785;GO:0000793;GO:0003677;GO:0003690;GO:0005634;GO:0005635;GO:0005654;GO:0005694;GO:0005737;GO:0005829;GO:0006325;GO:0006979;GO:0007084;GO:0009615;GO:0010836;GO:0032480;GO:0042802;GO:0042803;GO:0045071;GO:0045824;GO:0051276;GO:0160049	chromatin [GO:0000785, IDA]; condensed chromosome [GO:0000793, IDA]; double-stranded DNA binding [GO:0003690, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, HDA]; nucleus [GO:0005634, IDA]; nuclear envelope [GO:0005635, EXP]; nucleoplasm [GO:0005654, IDA]; chromosome [GO:0005694, EXP]; cytoplasm [GO:0005737, EXP]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; chromatin organization [GO:0006325, IDA]; response to oxidative stress [GO:0006979, IDA]; mitotic nuclear membrane reassembly [GO:0007084, IDA]; negative regulation of protein ADP-ribosylation [GO:0010836, IDA]; negative regulation of type I interferon production [GO:0032480, IDA]; identical protein binding [GO:0042802, IPI]; protein homodimerization activity [GO:0042803, IPI]; negative regulation of viral genome replication [GO:0045071, IDA]; negative regulation of innate immune response [GO:0045824, IDA]; negative regulation of cGAS/STING signaling pathway [GO:0160049, IDA]	Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:3
Q9H503	BANF2	90	other characterized small protein	Evidence at protein level	5.0	2002-08-02	0	0	Barrier-to-autointegration factor-like protein (BAF-L) (Barrier-to-autointegration factor 2)	25	9	2	4	3	0	0	CF	1	1	1	GO:0000793;GO:0003677;GO:0005634;GO:0005737;GO:0042802;GO:0051276	nucleus [GO:0005634, HDA]; identical protein binding [GO:0042802, IPI]	May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.
A8MTZ0	BBIP1	92	other characterized small protein	Evidence at protein level	5.0	2008-07-01	0	0	BBSome-interacting protein 1 (BBSome-interacting protein of 10 kDa)	23	19	7	2	4	6	0	CP	0	1	1	GO:0005737;GO:0005829;GO:0005929;GO:0034464;GO:0036064;GO:0060170;GO:0060271;GO:0097500	cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; BBSome [GO:0034464, IDA]; BBSome [GO:0034464, IPI]; ciliary basal body [GO:0036064, IDA]; ciliary membrane [GO:0060170, IDA]; cilium assembly [GO:0060271, IMP]	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP 
Q9BUW7	BBLN	83	other characterized small protein	Evidence at protein level	5.0	2002-01-31	0	0	Bublin coiled-coil protein (UPF0184 protein C9orf16)	25	9	7	0	2	0	0	CFP	1	1	1	GO:0005828;GO:0005856;GO:0005882;GO:0030054;GO:0045110;GO:0060090;GO:0070161;GO:0120219	kinetochore microtubule [GO:0005828, IMP]; intermediate filament [GO:0005882, IMP]; cell junction [GO:0030054, IMP]; intermediate filament bundle assembly [GO:0045110, IMP]; molecular adaptor activity [GO:0060090, IMP]; anchoring junction [GO:0070161, EXP]; subapical part of cell [GO:0120219, IMP]	Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology. {ECO:0000269|PubMed:33857431}.
P62952	BLCAP	87	other characterized small protein	Evidence at protein level	5.0	2004-08-31	0	1	Apoptosis inducing factor BLCAP (Bladder cancer 10 kDa protein) (Bc10) (Bladder cancer-associated protein)	22	4	1	0	3	0	0	P	0	1	1	GO:0005634;GO:0005737;GO:0016020;GO:0030262	apoptotic nuclear changes [GO:0030262, IDA]	Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms (PubMed:16675915, PubMed:17031575, PubMed:21844121, PubMed:26986503). Modulates expression of genes involved in the regulation of proliferation, 
Q9H3K6	BOLA2; BOLA2B	86	other characterized small protein	Evidence at protein level	5.0	2004-04-26	0	0	BolA-like protein 2	23	19	7	4	5	3	0	CP	1	1	1	GO:0005634;GO:0005737;GO:0005829;GO:0006879;GO:0016226;GO:0044571;GO:0045454;GO:0051536;GO:0051537;GO:0051604;GO:1990229	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; intracellular iron ion homeostasis [GO:0006879, IDA]; iron-sulfur cluster assembly [GO:0016226, IDA]; [2Fe-2S] cluster assembly [GO:0044571, IDA]; cell redox homeostasis [GO:0045454, IDA]; iron-sulfur cluster assembly complex [GO:1990229, IPI]	Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269|PubMed:26613676, ECO
Q8WUW1	BRK1	75	other characterized small protein	Evidence at protein level	5.0	2007-04-03	0	0	Protein BRICK1 (BRK1)	98	27	11	3	5	8	0	CFP	1	1	1	GO:0005829;GO:0005856;GO:0007015;GO:0008064;GO:0010592;GO:0016601;GO:0030027;GO:0031209;GO:0031267;GO:0031334;GO:0042802;GO:0044877;GO:0048870;GO:0070062;GO:2000601	positive regulation of lamellipodium assembly [GO:0010592, IDA]; positive regulation of lamellipodium assembly [GO:0010592, IMP]; Rac protein signal transduction [GO:0016601, IDA]; SCAR complex [GO:0031209, IDA]; small GTPase binding [GO:0031267, IDA]; positive regulation of protein-containing complex assembly [GO:0031334, IMP]; identical protein binding [GO:0042802, IDA]; protein-containing complex binding [GO:0044877, IPI]; extracellular exosome [GO:0070062, HDA]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601, IDA]	Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q91VR8, ECO:0000269|PubM
Q7Z7J9	CAMK2N1	78	other characterized small protein	Evidence at protein level	3.0	2008-06-10	0	0	Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CaMKII inhibitory protein alpha) (CaMKIIN-alpha)	16	16	0	2	9	5	0		1	1	1	GO:0004860;GO:0007616;GO:0008427;GO:0014069;GO:0019901;GO:0030425;GO:0045202;GO:0050729		Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of
Q96S95	CAMK2N2	79	other characterized small protein	Evidence at protein level	3.0	2008-04-08	0	0	Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein) (CaM-KIIN)	13	13	0	2	8	3	0		1	0	1	GO:0004860;GO:0005634;GO:0005829;GO:0008427;GO:0019901;GO:0045202		Potent and specific cellular inhibitor of CaM-kinase II (CAMK2) (PubMed:11444830). Traps Ca(2+)/calmodulin on CAMK2 (By similarity). {ECO:0000250|UniProtKB:Q9Z2N6, ECO:0000269|PubMed:11444830}.
P57730	CARD18	90	other characterized small protein	Evidence at protein level	4.0	2001-01-11	0	0	Caspase recruitment domain-containing protein 18 (Caspase-1 inhibitor Iceberg)	18	14	7	0	6	1	0	CFP	1	1	1	GO:0004197;GO:0006508;GO:0006954;GO:0019899;GO:0032651;GO:0032691;GO:0032991;GO:0042981;GO:0050700;GO:0089720	negative regulation of interleukin-1 beta production [GO:0032691, IDA]; protein-containing complex [GO:0032991, IDA]; CARD domain binding [GO:0050700, IPI]; caspase binding [GO:0089720, IPI]	Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. {ECO:0000269|PubMed:11051551}.
Q8IU53	CASC2	76	other characterized small protein	Predicted	2.0	2008-03-18	0	0	Protein CASC2, isoforms 1/2 (Cancer susceptibility candidate gene 2 protein isoforms 1/2)	0	0	0	0	0	0	0		0	0	0			
Q13166	CATR1	79	other characterized small protein	Evidence at transcript level	1.0	1997-11-01	0	0	CATR tumorigenic conversion 1 protein (CATR1.3)	3	0	0	0	0	0	1		0	0	0			
Q9P0B6	CCDC167	97	other characterized small protein	Evidence at protein level	5.0	2007-10-23	0	1	Coiled-coil domain-containing protein 167	38	1	0	0	1	0	0		0	0	1	GO:0016020		
Q8NHZ8	CDC26	85	other characterized small protein	Evidence at protein level	5.0	2007-01-09	0	0	Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog)	66	55	8	3	4	40	0	CP	0	1	1	GO:0005634;GO:0005654;GO:0005680;GO:0005829;GO:0007346;GO:0016567;GO:0031145;GO:0051445;GO:0070936;GO:0070979;GO:0141198	anaphase-promoting complex [GO:0005680, IDA]; anaphase-promoting complex [GO:0005680, IPI]; anaphase-promoting complex-dependent catabolic process [GO:0031145, IDA]; protein K48-linked ubiquitination [GO:0070936, IDA]; protein K11-linked ubiquitination [GO:0070979, IDA]; protein branched polyubiquitination [GO:0141198, IDA]	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin
Q9NRR8	CDC42SE1	79	other characterized small protein	Evidence at protein level	5.0	2008-05-20	0	0	CDC42 small effector protein 1 (CDC42-binding protein SCIP1) (Small effector of CDC42 protein 1)	12	9	1	1	4	3	0	C	1	1	1	GO:0005095;GO:0005856;GO:0005886;GO:0007165;GO:0030054;GO:0031267;GO:0035023	cell junction [GO:0030054, IDA]	Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in earl
Q9NRR3	CDC42SE2	84	other characterized small protein	Evidence at protein level	5.0	2008-05-20	0	0	CDC42 small effector protein 2 (Small effector of CDC42 protein 2)	10	9	3	1	5	0	0	CFP	1	1	1	GO:0001891;GO:0005856;GO:0005886;GO:0009966;GO:0031267;GO:0035023;GO:0035591	plasma membrane [GO:0005886, IDA]; regulation of signal transduction [GO:0009966, IDA]; signaling adaptor activity [GO:0035591, IDA]	Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in earl
Q5EE01	CENPW	88	other characterized small protein	Evidence at protein level	5.0	2007-11-13	0	0	Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)	37	31	10	5	8	8	0	CP	1	1	1	GO:0000278;GO:0000775;GO:0000776;GO:0000939;GO:0003677;GO:0005634;GO:0005654;GO:0005730;GO:0007059;GO:0016363;GO:0034080;GO:0046982;GO:0051276;GO:0051382	mitotic cell cycle [GO:0000278, IMP]; chromosome, centromeric region [GO:0000775, IDA]; kinetochore [GO:0000776, IDA]; inner kinetochore [GO:0000939, IPI]; nucleus [GO:0005634, EXP]; nucleoplasm [GO:0005654, IDA]; chromosome segregation [GO:0007059, IMP]; nuclear matrix [GO:0016363, EXP]; chromosome organization [GO:0051276, IMP]; kinetochore assembly [GO:0051382, IMP]	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorpo
A8MT69	CENPX	81	other characterized small protein	Evidence at protein level	5.0	2008-05-20	0	0	Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog)	46	39	13	4	4	18	0	CFP	1	1	1	GO:0000712;GO:0000775;GO:0000785;GO:0000939;GO:0003677;GO:0003690;GO:0005634;GO:0005654;GO:0005829;GO:0006281;GO:0007059;GO:0031297;GO:0031398;GO:0036297;GO:0043240;GO:0051382;GO:0071821	resolution of meiotic recombination intermediates [GO:0000712, IMP]; chromatin [GO:0000785, IDA]; inner kinetochore [GO:0000939, IPI]; DNA binding [GO:0003677, IDA]; double-stranded DNA binding [GO:0003690, IDA]; nucleus [GO:0005634, EXP]; replication fork processing [GO:0031297, IMP]; interstrand cross-link repair [GO:0036297, IDA]; Fanconi anaemia nuclear complex [GO:0043240, IDA]; FANCM-MHF complex [GO:0071821, IDA]; FANCM-MHF complex [GO:0071821, IPI]	DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:203
Q9BUK0	CHCHD7	85	other characterized small protein	Evidence at protein level	4.0	2005-04-12	0	0	Coiled-coil-helix-coiled-coil-helix domain-containing protein 7	4	4	1	2	1	0	0	C	0	1	1	GO:0005739;GO:0005758;GO:0033108	mitochondrion [GO:0005739, HTP]	
P61024	CKS1B	79	other characterized small protein	Evidence at protein level	5.0	2004-04-26	0	0	Cyclin-dependent kinases regulatory subunit 1 (CKS-1)	98	14	0	7	1	6	0		1	1	1	GO:0000307;GO:0005654;GO:0007346;GO:0016538;GO:0019005;GO:0019901;GO:0042393;GO:0043130;GO:0061575		Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
P33552	CKS2	79	other characterized small protein	Evidence at protein level	3.0	1994-02-01	0	0	Cyclin-dependent kinases regulatory subunit 2 (CKS-2)	13	9	0	7	2	0	0		1	1	1	GO:0000307;GO:0003682;GO:0007346;GO:0016538;GO:0019005;GO:0019901;GO:0042393;GO:0043130;GO:0061575		Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Q9NRP2	CMC2	79	other characterized small protein	Evidence at protein level	3.0	2003-10-24	0	0	COX assembly mitochondrial protein 2 homolog	7	5	3	1	1	0	0	C	0	0	1	GO:0005739	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}.
P56277	CMC4	68	other characterized small protein	Evidence at protein level	4.0	1998-07-15	0	0	Cx9C motif-containing protein 4 (Mature T-cell proliferation 1 neighbor protein) (Mature T-cell proliferation-1 type A) (MTCP-1 type A) (Protein p8 MTCP-1) (p8MTCP1)	5	5	3	1	1	0	0	C	0	0	1	GO:0005739;GO:0005758	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	
Q3B7I2	CNPY1	92	other characterized small protein	Evidence at protein level	1.0	2008-02-26	0	0	Protein canopy homolog 1	0	0	0	0	0	0	0		0	0	0			
Q7Z4G1	COMMD6	85	other characterized small protein	Evidence at protein level	5.0	2004-08-16	0	0	COMM domain-containing protein 6	41	11	4	2	2	3	0	CFP	1	1	1	GO:0000122;GO:0005634;GO:0005737;GO:0005789;GO:0007165;GO:0010008;GO:0032456;GO:0032991;GO:0051059	negative regulation of transcription by RNA polymerase II [GO:0000122, IDA]; nucleus [GO:0005634, EXP]; protein-containing complex [GO:0032991, IDA]; NF-kappaB binding [GO:0051059, IPI]	Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complex
Q8WXC6	COPS9	57	other characterized small protein	Evidence at protein level	5.0	2008-04-29	0	0	COP9 signalosome complex subunit 9 (CSN acidic protein) (CSNAP) (Myeloma-overexpressed gene 2 protein)	22	14	11	0	3	0	0	CP	0	1	1	GO:0000785;GO:0005634;GO:0005654;GO:0005737;GO:0008180;GO:0008284;GO:0034644;GO:1904750;GO:2000435	chromatin [GO:0000785, IDA]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; cytoplasm [GO:0005737, IDA]; COP9 signalosome [GO:0008180, IDA]; positive regulation of cell population proliferation [GO:0008284, IMP]; cellular response to UV [GO:0034644, IDA]; negative regulation of protein localization to nucleolus [GO:1904750, IMP]; negative regulation of protein neddylation [GO:2000435, IMP]	[Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes
Q9UGL9	CRCT1	99	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	0	Cysteine-rich C-terminal protein 1 (Protein NICE-1)	65	0	0	0	0	0	1		0	0	0			
P50238	CRIP1	77	other characterized small protein	Evidence at protein level	5.0	1996-10-01	0	0	Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP)	16	16	12	3	0	1	0	CFP	1	1	1	GO:0005737;GO:0006955;GO:0007507;GO:0008270;GO:0008630;GO:0010043;GO:0010468;GO:0042277;GO:0060741;GO:0071236;GO:0071493	cytoplasm [GO:0005737, IDA]; immune response [GO:0006955, IEP]; zinc ion binding [GO:0008270, IDA]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630, IDA]; response to zinc ion [GO:0010043, IDA]; regulation of gene expression [GO:0010468, IEP]; peptide binding [GO:0042277, IDA]; prostate gland stromal morphogenesis [GO:0060741, IEP]; cellular response to antibiotic [GO:0071236, IDA]; cellular response to UV-B [GO:0071493, IDA]	Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
P01040	CSTA	98	other characterized small protein	Evidence at protein level	5.0	1986-07-21	0	0	Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]	35	26	12	2	5	7	0	CFP	1	1	1	GO:0001533;GO:0002020;GO:0004866;GO:0004869;GO:0005576;GO:0005737;GO:0005829;GO:0018149;GO:0030216;GO:0045861;GO:0098609;GO:1904090	cornified envelope [GO:0001533, IDA]; protease binding [GO:0002020, IPI]; cysteine-type endopeptidase inhibitor activity [GO:0004869, IDA]; extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, IDA]; peptide cross-linking [GO:0018149, IDA]; keratinocyte differentiation [GO:0030216, IDA]; negative regulation of proteolysis [GO:0045861, IDA]; cell-cell adhesion [GO:0098609, IMP]; peptidase inhibitor complex [GO:1904090, IPI]	This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. {ECO:0000269|PubMed:21944047}.
P04080	CSTB	98	other characterized small protein	Evidence at protein level	5.0	1986-11-01	0	0	Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)	34	34	19	2	6	7	0	CFP	1	1	1	GO:0002020;GO:0003723;GO:0004866;GO:0004869;GO:0005576;GO:0005634;GO:0005730;GO:0005737;GO:0005829;GO:0031012;GO:0034774;GO:0045861;GO:0070062;GO:1904724;GO:1904813	protease binding [GO:0002020, IDA]; protease binding [GO:0002020, IPI]; RNA binding [GO:0003723, HDA]; endopeptidase inhibitor activity [GO:0004866, IDA]; cysteine-type endopeptidase inhibitor activity [GO:0004869, IDA]; extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; nucleus [GO:0005634, IDA]; nucleolus [GO:0005730, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; extracellular matrix [GO:0031012, HDA]; negative regulation of proteolysis [GO:0045861, IDA]; extracellular exosome [GO:0070062, HDA]	This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Q9HC47	CTAGE1	74	other characterized small protein	Evidence at transcript level	2.0	2005-01-04	0	1	Cutaneous T-cell lymphoma-associated antigen 1 (Protein cTAGE-1) (Cancer/testis antigen 21.1) (CT21.1)	2	1	0	0	1	0	0		0	0	1	GO:0016020		
Q9NSA3	CTNNBIP1	81	other characterized small protein	Evidence at protein level	5.0	2003-03-28	0	0	Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)	63	39	20	5	13	1	0	CFP	1	1	1	GO:0000122;GO:0001223;GO:0002528;GO:0005634;GO:0005654;GO:0005737;GO:0005829;GO:0008013;GO:0008285;GO:0030178;GO:0030877;GO:0031333;GO:0032991;GO:0045657;GO:0045669;GO:0048662;GO:0060070;GO:0060633;GO:0070016;GO:0072201;GO:0090090;GO:0140416;GO:1990711	negative regulation of transcription by RNA polymerase II [GO:0000122, IDA]; transcription coactivator binding [GO:0001223, IPI]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528, IMP]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; beta-catenin binding [GO:0008013, IPI]; beta-catenin destruction complex [GO:0030877, IDA]; negative regulation of protein-containing complex assembly [GO:0031333, IDA]; positive regulation of monocyte differentiation [GO:0045657, IMP]; positive regulation of osteoblast differentiation [GO:0045669, IMP]; canonical Wnt signaling pathway [GO:0060070, IDA]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633, IDA]; armadillo repeat domain binding [GO:0070016, IPI]; negative regulation of mesenchymal cell proliferation [GO:0072201, IMP]; negative regulation of canonical Wnt signaling pathway [GO:0090090, IDA]; negative regulation of canonical Wnt signaling pathway [GO:0090090, IMP]; transcription regulator inhibitor activity [GO:0140416, IDA]	Prevents the interaction between CTNNB1 and TCF family members, and acts as a negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.
P60606	CTXN1	82	other characterized small protein	Evidence at protein level	2.0	2004-03-15	0	1	Cortexin-1	1	1	0	0	1	0	0		0	0	1	GO:0016020		May mediate extracellular or intracellular signaling of cortical neurons during forebrain development. {ECO:0000250}.
P0C2S0	CTXN2	81	other characterized small protein	Inferred from homology	2.0	2007-04-17	0	1	Cortexin-2	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q4LDR2	CTXN3	81	other characterized small protein	Evidence at protein level	5.0	2007-04-17	0	1	Cortexin-3 (Kidney and brain-expressed protein)	59	1	0	0	1	0	0		0	0	1	GO:0016020		
Q9H1C7	CYSTM1	97	other characterized small protein	Evidence at protein level	3.0	2007-07-24	0	1	Cysteine-rich transmembrane module-containing protein 1	7	4	1	0	1	2	0	C	0	0	1	GO:0005886;GO:0016020;GO:0070062;GO:0070821	extracellular exosome [GO:0070062, HDA]	
P07108	DBI	87	other characterized small protein	Evidence at protein level	5.0	1988-04-01	0	0	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)	22	20	13	2	3	2	0	CFP	1	1	1	GO:0000062;GO:0005783;GO:0005788;GO:0005794;GO:0006631;GO:0030156;GO:0032994;GO:0036042;GO:0036151;GO:0042802;GO:0070062;GO:0097038;GO:2001140	endoplasmic reticulum [GO:0005783, EXP]; endoplasmic reticulum [GO:0005783, IDA]; Golgi apparatus [GO:0005794, EXP]; Golgi apparatus [GO:0005794, IDA]; protein-lipid complex [GO:0032994, IDA]; long-chain fatty acyl-CoA binding [GO:0036042, IDA]; phosphatidylcholine acyl-chain remodeling [GO:0036151, IDA]; identical protein binding [GO:0042802, IPI]; extracellular exosome [GO:0070062, HDA]; perinuclear endoplasmic reticulum [GO:0097038, IDA]; positive regulation of phospholipid transport [GO:2001140, IDA]	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein al
Q9P2X7	DELEC1	70	other characterized small protein	Evidence at transcript level	2.0	2006-06-27	0	0	Deleted in esophageal cancer 1 (Candidate tumor suppressor CTS9)	1	1	0	0	0	1	0		0	1	0	GO:0008285		Candidate tumor suppressor. {ECO:0000269|PubMed:10612805}.
O95424	DEXI	95	other characterized small protein	Evidence at protein level	3.0	2000-05-30	0	0	Dexamethasone-induced protein (Protein MYLE)	10	0	0	0	0	0	1		0	0	0			
O43261	DLEU1	78	other characterized small protein	Evidence at protein level	2.0	2000-12-01	0	0	Leukemia-associated protein 1 (Deleted in lymphocytic leukemia 1) (HBV X-transactivated gene 6 protein) (HBV XAg-transactivated protein 6)	1	0	0	0	0	0	1		0	0	0			May act as a tumor suppressor.
Q96FX2	DPH3	82	other characterized small protein	Evidence at protein level	5.0	2003-04-04	0	0	Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1)	32	23	6	3	8	6	0	CP	1	1	1	GO:0002926;GO:0005506;GO:0005634;GO:0005654;GO:0005737;GO:0005829;GO:0008198;GO:0017183;GO:0032991;GO:0034986;GO:0046872;GO:0050709;GO:0051099	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; negative regulation of protein secretion [GO:0050709, IDA]; positive regulation of binding [GO:0051099, IDA]	Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction
O94777	DPM2	84	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	1	Dolichol phosphate-mannose biosynthesis regulatory protein (Dolichol-phosphate mannose synthase subunit 2) (DPM synthase subunit 2)	34	27	10	4	4	9	0	CFP	1	1	1	GO:0000506;GO:0005783;GO:0005789;GO:0006506;GO:0008047;GO:0030234;GO:0033185;GO:0043048;GO:0180047	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506, IDA]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506, IPI]; endoplasmic reticulum membrane [GO:0005789, IDA]; GPI anchor biosynthetic process [GO:0006506, IDA]; enzyme activator activity [GO:0008047, IDA]; dolichol-phosphate-mannose synthase complex [GO:0033185, IDA]; dolichol-phosphate-mannose synthase complex [GO:0033185, IPI]; dolichyl monophosphate biosynthetic process [GO:0043048, IDA]; dolichol phosphate mannose biosynthetic process [GO:0180047, IDA]	Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:10835346). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:10835346). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltra
Q9P2X0	DPM3	92	other characterized small protein	Evidence at protein level	5.0	2002-01-23	0	1	Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1)	31	20	9	2	2	7	0	CFP	1	1	1	GO:0005783;GO:0005789;GO:0008047;GO:0009101;GO:0016020;GO:0033185;GO:0035269;GO:0043048;GO:0043495;GO:0180047	endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum membrane [GO:0005789, IDA]; enzyme activator activity [GO:0008047, IDA]; membrane [GO:0016020, HDA]; dolichol-phosphate-mannose synthase complex [GO:0033185, IDA]; dolichol-phosphate-mannose synthase complex [GO:0033185, IPI]; dolichyl monophosphate biosynthetic process [GO:0043048, IDA]; dolichol phosphate mannose biosynthetic process [GO:0180047, IDA]	Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum. {ECO:0000269|PubMed:10835346}.
Q9C005	DPY30	99	other characterized small protein	Evidence at protein level	5.0	2001-07-11	0	0	Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)	102	60	20	0	4	36	0	CFP	1	1	1	GO:0005634;GO:0005654;GO:0005794;GO:0005802;GO:0016197;GO:0035097;GO:0042802;GO:0042803;GO:0044665;GO:0044666;GO:0045815;GO:0048188;GO:0071339	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; Golgi apparatus [GO:0005794, IDA]; trans-Golgi network [GO:0005802, IDA]; endosomal transport [GO:0016197, IMP]; histone methyltransferase complex [GO:0035097, IDA]; identical protein binding [GO:0042802, IPI]; protein homodimerization activity [GO:0042803, IPI]; MLL1/2 complex [GO:0044665, IPI]; MLL3/4 complex [GO:0044666, IDA]; MLL3/4 complex [GO:0044666, IPI]; transcription initiation-coupled chromatin remodeling [GO:0045815, IDA]; Set1C/COMPASS complex [GO:0048188, IDA]; Set1C/COMPASS complex [GO:0048188, IPI]; MLL1 complex [GO:0071339, IPI]	As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a cru
P59022	DSCR10	87	other characterized small protein	Uncertain	1.0	2002-09-19	0	0	Down syndrome critical region protein 10	3	0	0	0	0	0	1		0	0	0			
Q96T75	DSCR8	97	other characterized small protein	Evidence at protein level	3.0	2002-10-10	0	0	Down syndrome critical region protein 8 (Cancer/testis antigen 25) (CT25) (DCR1-24.0) (Malignant melanoma-associated protein 1) (MMA-1) (Protein MTAG2)	2	0	0	0	0	0	1		0	0	0			
P63167	DYNLL1	89	other characterized small protein	Evidence at protein level	5.0	2004-09-27	0	0	Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)	223	129	21	4	29	75	0	CFP	1	1	1	GO:0000776;GO:0001673;GO:0004857;GO:0005634;GO:0005654;GO:0005694;GO:0005737;GO:0005739;GO:0005813;GO:0005829;GO:0005856;GO:0005868;GO:0005875;GO:0005886;GO:0005929;GO:0007017;GO:0007286;GO:0008180;GO:0015630;GO:0016020;GO:0019899;GO:0019904;GO:0021762;GO:0030141;GO:0030235;GO:0030286;GO:0032388;GO:0035721;GO:0035774;GO:0035861;GO:0036487;GO:0042326;GO:0042802;GO:0044458;GO:0044877;GO:0045505;GO:0070821;GO:0072686;GO:0090267;GO:0097110;GO:0097542;GO:0101003;GO:0110027;GO:1904115	kinetochore [GO:0000776, IDA]; enzyme inhibitor activity [GO:0004857, IDA]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; chromosome [GO:0005694, EXP]; cytoplasm [GO:0005737, IDA]; mitochondrion [GO:0005739, EXP]; centrosome [GO:0005813, IDA]; cytoskeleton [GO:0005856, IDA]; cytoplasmic dynein complex [GO:0005868, IDA]; cytoplasmic dynein complex [GO:0005868, IPI]; COP9 signalosome [GO:0008180, IDA]; membrane [GO:0016020, HDA]; substantia nigra development [GO:0021762, HEP]; site of double-strand break [GO:0035861, IDA]; negative regulation of phosphorylation [GO:0042326, IDA]; mitotic spindle [GO:0072686, IDA]; negative regulation of DNA strand resection involved in replication fork processing [GO:0110027, IDA]	Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be i
Q96FJ2	DYNLL2	89	other characterized small protein	Evidence at protein level	5.0	2004-12-21	0	0	Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)	137	78	9	2	14	53	0	C	1	1	1	GO:0001534;GO:0001673;GO:0003341;GO:0005634;GO:0005813;GO:0005829;GO:0005856;GO:0005868;GO:0005875;GO:0005886;GO:0005929;GO:0005930;GO:0007017;GO:0014069;GO:0015630;GO:0016020;GO:0030286;GO:0030317;GO:0031475;GO:0032388;GO:0035721;GO:0036126;GO:0042802;GO:0044877;GO:0045505;GO:0090267;GO:0097110;GO:0097542;GO:0097729;GO:0097731;GO:0098794;GO:0098978	nucleus [GO:0005634, HDA]; centrosome [GO:0005813, IDA]; cytoskeleton [GO:0005856, IDA]; membrane [GO:0016020, HDA]; 9+0 non-motile cilium [GO:0097731, IDA]; postsynapse [GO:0098794, IDA]; postsynapse [GO:0098794, IMP]; glutamatergic synapse [GO:0098978, IDA]; glutamatergic synapse [GO:0098978, IMP]	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles 
Q9NP97	DYNLRB1	96	other characterized small protein	Evidence at protein level	5.0	2003-04-23	0	0	Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)	44	36	3	5	6	22	0	C	1	1	1	GO:0003777;GO:0005737;GO:0005813;GO:0005856;GO:0005868;GO:0005929;GO:0007018;GO:0007632;GO:0016020;GO:0030286;GO:0032388;GO:0035721;GO:0042802;GO:0045505;GO:0090267;GO:0097542	centrosome [GO:0005813, IDA]; cytoplasmic dynein complex [GO:0005868, IPI]; membrane [GO:0016020, HDA]	Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be i
Q8TF09	DYNLRB2	96	other characterized small protein	Evidence at protein level	5.0	2003-04-23	0	0	Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic) (Roadblock domain-containing protein 2)	28	28	0	5	5	18	0		1	1	1	GO:0001673;GO:0003777;GO:0005737;GO:0005813;GO:0005856;GO:0005868;GO:0005929;GO:0007018;GO:0030286;GO:0032388;GO:0035721;GO:0045505;GO:0090267;GO:0097542		Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles 
O60516	EIF4EBP3	100	other characterized small protein	Evidence at protein level	5.0	2003-09-19	0	0	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)	22	14	3	3	5	3	0	C	1	1	1	GO:0005634;GO:0005737;GO:0008190;GO:0016020;GO:0016281;GO:0030371;GO:0045947	nucleus [GO:0005634, EXP]; cytoplasm [GO:0005737, EXP]; membrane [GO:0016020, HDA]	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from E
P60002	ELOF1	83	other characterized small protein	Evidence at protein level	5.0	2003-11-14	0	0	Transcription elongation factor 1 homolog	16	14	9	3	2	0	0	CFP	1	1	1	GO:0000993;GO:0005634;GO:0005694;GO:0006283;GO:0006368;GO:0008023;GO:0030674	RNA polymerase II complex binding [GO:0000993, IDA]; nucleus [GO:0005634, IDA]; chromosome [GO:0005694, IDA]; transcription-coupled nucleotide-excision repair [GO:0006283, IDA]; protein-macromolecule adaptor activity [GO:0030674, IDA]	Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:34108662, PubMed:34108663, PubMed:38316879). Acts as a key adapter required to anchor TC-NER factors t
P61580	ERVK-10	75	other characterized small protein	Evidence at protein level	2.0	2004-05-24	0	0	Endogenous retrovirus group K member 10 Np9 protein (HERV-K10 Np9 protein) (HERV-K107 Np9 protein) (HERV-K_5q33.3 provirus Np9 protein)	1	1	0	0	1	0	0		0	0	1	GO:0005634		May possess a function in tumorigenesis. {ECO:0000250}.
P61581	ERVK-24	75	other characterized small protein	Evidence at protein level	2.0	2004-05-24	0	0	Endogenous retrovirus group K member 24 Np9 protein (HERV-K101 Np9 protein) (HERV-K_22q11.21 provirus Np9 protein)	1	1	0	0	1	0	0		0	0	1	GO:0005634		May possess a function in tumorigenesis.
P61583	ERVK-5	75	other characterized small protein	Inferred from homology	2.0	2004-05-24	0	0	Endogenous retrovirus group K member 5 Np9 protein (Endogenous retrovirus K protein 5) (HERV-K(II) Np9 protein) (HERV-K_3q12.3 provirus Np9 protein)	1	1	0	0	1	0	0		0	0	1	GO:0005634		May possess a function in tumorigenesis. {ECO:0000250}.
P61582	ERVK-7	75	other characterized small protein	Inferred from homology	2.0	2004-05-24	0	0	Endogenous retrovirus group K member 7 Np9 protein (HERV-K(III) Np9 protein) (HERV-K102 Np9 protein) (HERV-K_1q22 provirus Np9 protein)	1	1	0	0	1	0	0		0	0	1	GO:0005634		May possess a function in tumorigenesis. {ECO:0000250}.
Q6IPR1	ETFRF1	90	other characterized small protein	Evidence at protein level	4.0	2006-10-03	0	0	Electron transfer flavoprotein regulatory factor 1 (LYR motif-containing protein 5)	15	8	4	2	2	0	0	CFP	1	1	1	GO:0004857;GO:0005739;GO:0090324;GO:1901856	enzyme inhibitor activity [GO:0004857, IDA]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; negative regulation of oxidative phosphorylation [GO:0090324, IMP]	Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). {ECO:0000269|PubMed:27499296}.
Q4G0N7	FAM229B	80	other characterized small protein	Evidence at protein level	2.0	2008-05-20	0	0	Protein FAM229B	3	0	0	0	0	0	1		0	0	0			
B3EWG3	FAM25A	89	other characterized small protein	Evidence at protein level	4.0	2012-03-21	0	0	Protein FAM25A	18	0	0	0	0	0	1		0	0	0			
B3EWG5	FAM25C	89	other characterized small protein	Inferred from homology	1.0	2012-03-21	0	0	Protein FAM25C	0	0	0	0	0	0	0		0	0	0			
B3EWG6	FAM25G	89	other characterized small protein	Inferred from homology	1.0	2012-03-21	0	0	Protein FAM25G	0	0	0	0	0	0	0		0	0	0			
Q5VT28	FAM27B; FAM27C	67	other characterized small protein	Evidence at protein level	2.0	2006-12-12	0	0	Protein FAM27A/B/C	0	0	0	0	0	0	0		0	0	0			
C9JXX5	FREY1	98	other characterized small protein	Inferred from homology	3.0	2010-05-18	0	1	Protein Frey 1 (Frey regulator of sperm-oocyte fusion 1) (FREY1)	17	17	0	3	8	6	0		1	1	1	GO:0005789;GO:0007342;GO:0016020;GO:0030674;GO:0035036;GO:0035437;GO:0065003		Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released
P54710	FXYD2	66	other characterized small protein	Evidence at protein level	5.0	1996-10-01	0	1	Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain)	30	28	2	2	13	11	0	C	1	1	1	GO:0001671;GO:0005886;GO:0005890;GO:0006811;GO:0006812;GO:0008285;GO:0010248;GO:0016020;GO:0016323;GO:0017080;GO:0030674;GO:0036376;GO:0043269;GO:0055085;GO:0070062;GO:0071475;GO:0099106;GO:1902600;GO:1903278;GO:1990573	sodium:potassium-exchanging ATPase complex [GO:0005890, IPI]; extracellular exosome [GO:0070062, HDA]	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
P58549	FXYD7	80	other characterized small protein	Evidence at protein level	4.0	2002-01-23	0	1	FXYD domain-containing ion transport regulator 7	23	19	0	2	8	9	0		1	1	1	GO:0005886;GO:0006883;GO:0010248;GO:0016020;GO:0017080;GO:0030007;GO:0036376;GO:0043269;GO:0051117;GO:0099106;GO:1902600;GO:1903278;GO:1990573		Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:33231612). Reduces the apparent affinity for external K(+), an effect that depends on
P30047	GCHFR	84	other characterized small protein	Evidence at protein level	5.0	1993-04-01	0	0	GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35)	17	15	6	3	4	2	0	C	1	1	1	GO:0004857;GO:0005634;GO:0005654;GO:0005737;GO:0005829;GO:0030425;GO:0031965;GO:0042470;GO:0044549;GO:0045428	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; cytoplasm [GO:0005737, IDA]; dendrite [GO:0030425, IDA]; nuclear membrane [GO:0031965, IDA]; melanosome [GO:0042470, IDA]	Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.
Q4G0N0	GGTA1	100	other characterized small protein	Evidence at protein level	2.0	2008-05-20	0	1	Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase (Glycoprotein alpha-galactosyltransferase 1 pseudogene)	3	3	0	0	1	2	0		0	1	1	GO:0031985;GO:0032580;GO:1901750		
P50151	GNG10	68	other characterized small protein	Evidence at protein level	5.0	1996-10-01	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	17	10	0	3	4	3	0		1	1	1	GO:0003924;GO:0005834;GO:0005886;GO:0007165;GO:0007186;GO:0031681		Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta
P61952	GNG11	73	other characterized small protein	Evidence at protein level	5.0	2004-06-07	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	12	10	0	3	4	3	0		1	1	1	GO:0003924;GO:0005834;GO:0005886;GO:0007165;GO:0007186;GO:0031681		Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Q9UBI6	GNG12	72	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	18	13	3	3	5	2	0	CF	1	1	1	GO:0005834;GO:0005886;GO:0007165;GO:0007186;GO:0030165;GO:0031681;GO:0045202;GO:0070062	PDZ domain binding [GO:0030165, IDA]; extracellular exosome [GO:0070062, HDA]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Q9P2W3	GNG13	67	other characterized small protein	Evidence at protein level	5.0	2002-01-31	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	48	19	1	3	10	5	0	F	1	1	1	GO:0005834;GO:0005886;GO:0007186;GO:0007200;GO:0030425;GO:0031681;GO:0045202;GO:0050909	G-protein beta-subunit binding [GO:0031681, IPI]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P59768	GNG2	71	other characterized small protein	Evidence at protein level	5.0	2003-07-11	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)	101	93	6	3	5	79	0	CF	1	1	1	GO:0005834;GO:0005886;GO:0007186;GO:0007191;GO:0016020;GO:0031681;GO:0045202;GO:0070062;GO:0071380;GO:0071870	heterotrimeric G-protein complex [GO:0005834, IDA]; G-protein beta-subunit binding [GO:0031681, IPI]; extracellular exosome [GO:0070062, HDA]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935
P63215	GNG3	75	other characterized small protein	Evidence at protein level	5.0	2004-09-27	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	20	15	0	3	10	2	0		1	1	1	GO:0003924;GO:0005834;GO:0005886;GO:0007186;GO:0007204;GO:0014069;GO:0030425;GO:0031681;GO:0044297;GO:0045202		Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P50150	GNG4	75	other characterized small protein	Evidence at protein level	5.0	1996-10-01	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	35	13	2	3	5	3	0	CP	1	1	1	GO:0005834;GO:0005886;GO:0007186;GO:0008277;GO:0030308;GO:0031681;GO:0045202;GO:0070062	negative regulation of cell growth [GO:0030308, IMP]; extracellular exosome [GO:0070062, HDA]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}.
P63218	GNG5	68	other characterized small protein	Evidence at protein level	5.0	2004-09-27	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	31	18	5	3	5	5	0	CF	1	1	1	GO:0003924;GO:0005834;GO:0005886;GO:0007165;GO:0007186;GO:0016020;GO:0030165;GO:0031680;GO:0031681;GO:0070062	membrane [GO:0016020, HDA]; PDZ domain binding [GO:0030165, IDA]; extracellular exosome [GO:0070062, HDA]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
O60262	GNG7	68	other characterized small protein	Evidence at protein level	4.0	1999-07-15	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	16	13	4	3	4	2	0	C	1	1	1	GO:0005834;GO:0005886;GO:0007186;GO:0008277;GO:0031681;GO:0070062	extracellular exosome [GO:0070062, HDA]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (By similarity). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)
Q9UK08	GNG8	70	other characterized small protein	Evidence at protein level	4.0	2000-12-01	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9)	12	11	0	3	5	3	0		1	1	1	GO:0003924;GO:0005834;GO:0005886;GO:0007186;GO:0007399;GO:0031681		Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P63211	GNGT1	74	other characterized small protein	Evidence at protein level	5.0	2004-09-27	0	0	Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)	25	17	2	3	7	5	0	C	1	1	1	GO:0001750;GO:0001917;GO:0003924;GO:0005834;GO:0005886;GO:0007165;GO:0007186;GO:0031681;GO:0097381	heterotrimeric G-protein complex [GO:0005834, IPI]; plasma membrane [GO:0005886, IPI]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
O14610	GNGT2	69	other characterized small protein	Evidence at protein level	5.0	1998-07-15	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 (G gamma-C) (G-gamma-8) (G-gamma-9) (Guanine nucleotide binding protein gamma transducing activity polypeptide 2)	13	13	2	3	4	4	0	CF	1	1	1	GO:0003924;GO:0005834;GO:0005886;GO:0007186;GO:0007602;GO:0031681	GTPase activity [GO:0003924, IDA]; heterotrimeric G-protein complex [GO:0005834, IDA]	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Q9BXV9	GON7	100	other characterized small protein	Evidence at protein level	5.0	2005-08-30	0	0	EKC/KEOPS complex subunit GON7	16	11	7	1	2	1	0	CP	0	1	1	GO:0000408;GO:0002949;GO:0005634;GO:0005654;GO:0005730;GO:1990145	EKC/KEOPS complex [GO:0000408, IDA]; EKC/KEOPS complex [GO:0000408, IPI]; tRNA threonylcarbamoyladenosine modification [GO:0002949, IDA]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; nucleolus [GO:0005730, IDA]	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:27903914, PubMed:31481669). The complex is probably involved in the transfer of the threonylcarbamoyl moie
Q6ZYL4	GTF2H5	71	other characterized small protein	Evidence at protein level	5.0	2005-06-07	0	0	General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) (TFIIH subunit p8)	105	84	5	4	6	69	0	CP	0	1	1	GO:0000439;GO:0005634;GO:0005654;GO:0005669;GO:0005675;GO:0005730;GO:0005737;GO:0006289;GO:0006294;GO:0006366;GO:0006367	nucleus [GO:0005634, EXP]; transcription factor TFIID complex [GO:0005669, IDA]; transcription factor TFIIH holo complex [GO:0005675, IPI]; nucleolus [GO:0005730, IDA]; nucleotide-excision repair [GO:0006289, IMP]	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA aroun
Q99525	H4C7	98	other characterized small protein	Evidence at protein level	4.0	2008-03-18	0	0	Histone H4-like protein type G (H4-clustered histone 7)	17	9	1	3	5	0	0	C	1	1	1	GO:0003677;GO:0005634;GO:0005694;GO:0006334;GO:0030527;GO:0046982	nucleus [GO:0005634, HDA]	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessib
Q6WQI6	HEPN1	88	other characterized small protein	Evidence at transcript level	2.0	2008-02-05	0	0	Protein HEPN1 (Cancer susceptibility gene HEPN1 protein)	1	1	0	0	1	0	0		0	0	1	GO:0005737		
Q9Y241	HIGD1A	93	other characterized small protein	Evidence at protein level	5.0	2005-09-27	0	1	HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a)	14	14	4	3	6	1	0	CP	0	1	1	GO:0005634;GO:0005739;GO:0005743;GO:0016020;GO:0031966;GO:0032991;GO:0043066;GO:0097250	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; protein-containing complex [GO:0032991, IDA]; negative regulation of apoptotic process [GO:0043066, IDA]	Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}.
Q9P298	HIGD1B	99	other characterized small protein	Evidence at protein level	2.0	2005-09-27	0	1	HIG1 domain family member 1B (Protein CLST 11240)	3	3	0	2	1	0	0		0	1	1	GO:0005739;GO:0016020;GO:0097250		
A8MV81	HIGD1C	97	other characterized small protein	Evidence at protein level	4.0	2008-07-01	0	1	HIG1 domain family member 1C	15	3	0	2	1	0	0		0	1	1	GO:0005739;GO:0016020;GO:0097250		
P05114	HMGN1	100	other characterized small protein	Evidence at protein level	5.0	1987-08-13	0	0	Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1)	14	13	2	3	5	3	0	C	1	1	1	GO:0000785;GO:0003677;GO:0003682;GO:0005634;GO:0005654;GO:0005737;GO:0006325;GO:0031492;GO:0032786	nucleus [GO:0005634, HDA]; nucleoplasm [GO:0005654, IDA]	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1
P05204	HMGN2	90	other characterized small protein	Evidence at protein level	5.0	1987-08-13	0	0	Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2)	20	17	9	3	5	0	0	CFP	1	1	1	GO:0000785;GO:0003682;GO:0003723;GO:0005576;GO:0005634;GO:0005654;GO:0005730;GO:0005737;GO:0006325;GO:0031492;GO:0031640;GO:0061844	RNA binding [GO:0003723, HDA]; extracellular region [GO:0005576, IDA]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; nucleolus [GO:0005730, IDA]; cytoplasm [GO:0005737, IDA]; killing of cells of another organism [GO:0031640, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}.
Q15651	HMGN3	99	other characterized small protein	Evidence at protein level	4.0	1997-11-01	0	0	High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7)	10	9	1	3	4	1	0	C	1	1	1	GO:0000785;GO:0003682;GO:0005634;GO:0005654;GO:0006325;GO:0031492;GO:0046966	nucleoplasm [GO:0005654, IDA]	Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expressio
O00479	HMGN4	90	other characterized small protein	Evidence at protein level	3.0	2002-01-31	0	0	High mobility group nucleosome-binding domain-containing protein 4 (Non-histone chromosomal protein HMG-17-like 3) (Non-histone chromosomal protein)	8	7	0	3	4	0	0		1	1	1	GO:0000785;GO:0003682;GO:0005634;GO:0006325;GO:0031492		
O97980	HMHB1	41	other characterized small protein	Evidence at protein level	5.0	2008-04-29	0	0	Minor histocompatibility protein HB-1 [Cleaved into: Minor histocompatibility antigen HB-1 (mHag HB-1)]	4	4	4	0	0	0	0	P	0	1	0	GO:0010468;GO:0032729;GO:0071356	regulation of gene expression [GO:0010468, IDA]; positive regulation of type II interferon production [GO:0032729, IDA]; positive regulation of type II interferon production [GO:0032729, IMP]; cellular response to tumor necrosis factor [GO:0071356, IDA]	Precursor of the histocompatibility antigen HB-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular prot
P0C7T4	HMSD	53	other characterized small protein	Evidence at protein level	3.0	2008-07-22	0	0	Minor histocompatibility protein HMSD variant form (HSMD-v) [Cleaved into: Minor histocompatibility antigen ACC-6 (mHA ACC-6)]	3	3	3	0	0	0	0	P	0	1	0	GO:0002253;GO:0019835;GO:0032729	activation of immune response [GO:0002253, IMP]; cytolysis [GO:0019835, IMP]; positive regulation of type II interferon production [GO:0032729, IMP]	This splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived
Q9BPY8	HOPX	73	other characterized small protein	Evidence at protein level	5.0	2005-02-01	0	0	Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1)	20	15	4	2	5	4	0	CP	1	1	1	GO:0000785;GO:0001829;GO:0003166;GO:0003677;GO:0005634;GO:0005737;GO:0006357;GO:0030154;GO:0045596;GO:0051131	trophectodermal cell differentiation [GO:0001829, IDA]; nucleus [GO:0005634, IDA]; negative regulation of cell differentiation [GO:0045596, IDA]; chaperone-mediated protein complex assembly [GO:0051131, IDA]	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibi
O00198	HRK	91	other characterized small protein	Evidence at protein level	5.0	1997-11-01	0	1	Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5)	16	12	4	2	6	0	0	CP	0	1	1	GO:0005739;GO:0016020;GO:0031334;GO:0042981;GO:0043065;GO:0043525;GO:0051365;GO:0090200	mitochondrion [GO:0005739, IDA]; positive regulation of protein-containing complex assembly [GO:0031334, IDA]; positive regulation of apoptotic process [GO:0043065, IMP]; positive regulation of release of cytochrome c from mitochondria [GO:0090200, IDA]	Promotes apoptosis. {ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:9130713}.
O75506	HSBP1	76	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	0	Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13)	47	16	4	3	4	5	0	CFP	1	1	1	GO:0000122;GO:0003714;GO:0005634;GO:0005654;GO:0005829;GO:0006936;GO:0016607;GO:0019896;GO:0042802;GO:0070370;GO:1904115	nuclear speck [GO:0016607, IDA]; axonal transport of mitochondrion [GO:0019896, IMP]; identical protein binding [GO:0042802, IPI]	Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
C9JCN9	HSBP1L1	74	other characterized small protein	Evidence at protein level	3.0	2010-06-15	0	0	Heat shock factor-binding protein 1-like protein 1	15	5	0	3	2	0	0		1	1	1	GO:0003714;GO:0005634;GO:0005829;GO:0045892;GO:0070370		
Q9Y5U9	IER3IP1	82	other characterized small protein	Evidence at protein level	5.0	2006-10-31	0	1	Immediate early response 3-interacting protein 1	56	17	11	4	1	1	0	CP	0	1	1	GO:0000139;GO:0000281;GO:0003331;GO:0005783;GO:0005789;GO:0006888;GO:0007420;GO:0016020;GO:0030134;GO:0031410;GO:0035265;GO:0050714;GO:2000269	mitotic cytokinesis [GO:0000281, IGI]; positive regulation of extracellular matrix constituent secretion [GO:0003331, IMP]; endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum membrane [GO:0005789, IDA]; brain development [GO:0007420, IDA]; membrane [GO:0016020, HDA]; cytoplasmic vesicle [GO:0031410, IDA]; organ growth [GO:0035265, IDA]; positive regulation of protein secretion [GO:0050714, IMP]; regulation of fibroblast apoptotic process [GO:2000269, IMP]	Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size (PubMed:33122427). Required for secretion of extracellular matrix proteins (PubMed:33122427). Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity a
Q9UBP8	KAAG1	84	other characterized small protein	Evidence at protein level	2.0	2007-02-06	0	0	Kidney-associated antigen 1 (RU2 antisense gene protein)	1	1	0	0	0	1	0		0	1	0	GO:0006955		
Q9H478	KCNQ1DN	68	other characterized small protein	Evidence at transcript level	1.0	2005-12-06	0	0	KCNQ1 downstream neighbor protein (Beckwith-Wiedemann region transcript protein)	3	0	0	0	0	0	1		0	0	0			
Q0VGL1	LAMTOR4	99	other characterized small protein	Evidence at protein level	5.0	2008-03-18	0	0	Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]	80	63	23	5	4	31	0	CFP	1	1	1	GO:0005085;GO:0005764;GO:0005765;GO:0008361;GO:0031669;GO:0031902;GO:0032008;GO:0038202;GO:0060090;GO:0061462;GO:0071230;GO:0071986;GO:1904263;GO:1990877	guanyl-nucleotide exchange factor activity [GO:0005085, IDA]; lysosome [GO:0005764, IDA]; lysosomal membrane [GO:0005765, IDA]; regulation of cell size [GO:0008361, IMP]; cellular response to nutrient levels [GO:0031669, IDA]; positive regulation of TOR signaling [GO:0032008, IMP]; molecular adaptor activity [GO:0060090, IDA]; protein localization to lysosome [GO:0061462, IMP]; cellular response to amino acid stimulus [GO:0071230, IDA]; cellular response to amino acid stimulus [GO:0071230, IMP]; Ragulator complex [GO:0071986, IDA]; Ragulator complex [GO:0071986, IPI]; positive regulation of TORC1 signaling [GO:1904263, IDA]; FNIP-folliculin RagC/D GAP [GO:1990877, IDA]	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated by 
O43504	LAMTOR5	91	other characterized small protein	Evidence at protein level	5.0	1999-07-15	0	0	Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)	106	73	30	5	5	33	0	CFP	1	1	1	GO:0005085;GO:0005737;GO:0005764;GO:0005765;GO:0005829;GO:0008361;GO:0009615;GO:0010628;GO:0019079;GO:0031669;GO:0031902;GO:0032008;GO:0032757;GO:0032991;GO:0038202;GO:0043066;GO:0043123;GO:0060090;GO:0061462;GO:0071230;GO:0071986;GO:1900182;GO:1904263;GO:1990877	guanyl-nucleotide exchange factor activity [GO:0005085, IDA]; lysosome [GO:0005764, IDA]; lysosomal membrane [GO:0005765, IDA]; cytosol [GO:0005829, IDA]; regulation of cell size [GO:0008361, IMP]; positive regulation of gene expression [GO:0010628, IGI]; cellular response to nutrient levels [GO:0031669, IDA]; positive regulation of TOR signaling [GO:0032008, IMP]; positive regulation of interleukin-8 production [GO:0032757, IGI]; protein-containing complex [GO:0032991, IDA]; negative regulation of apoptotic process [GO:0043066, IDA]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, IDA]; molecular adaptor activity [GO:0060090, IDA]; protein localization to lysosome [GO:0061462, IMP]; cellular response to amino acid stimulus [GO:0071230, IDA]; cellular response to amino acid stimulus [GO:0071230, IMP]; Ragulator complex [GO:0071986, IDA]; Ragulator complex [GO:0071986, IPI]; positive regulation of protein localization to nucleus [GO:1900182, IDA]; positive regulation of TORC1 signaling [GO:1904263, IDA]; FNIP-folliculin RagC/D GAP [GO:1990877, IDA]	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism in
Q5T871	LELP1	98	other characterized small protein	Evidence at protein level	4.0	2007-01-09	0	0	Late cornified envelope-like proline-rich protein 1 (Novel small proline-rich protein)	14	0	0	0	0	0	1		0	0	0			
Q9Y5L5	LENEP	61	other characterized small protein	Evidence at protein level	2.0	2000-05-30	0	0	Lens epithelial cell protein LEP503	3	2	0	0	0	2	0		1	1	0	GO:0002088;GO:0003677		May play a role in lens epithelial cell differentiation.
Q9Y333	LSM2	95	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	0	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	124	57	21	8	3	25	0	CFP	1	1	1	GO:0000244;GO:0000290;GO:0000387;GO:0000398;GO:0000932;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005688;GO:0005691;GO:0005737;GO:0005829;GO:0006397;GO:0006402;GO:0017070;GO:0031267;GO:0046540;GO:0071001;GO:0071002;GO:0071005;GO:0071009;GO:0071011;GO:0071013;GO:0120115;GO:1990726	spliceosomal tri-snRNP complex assembly [GO:0000244, IDA]; mRNA splicing, via spliceosome [GO:0000398, IDA]; RNA binding [GO:0003723, HDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; spliceosomal complex [GO:0005681, IPI]; cytoplasm [GO:0005737, IDA]; cytoplasm [GO:0005737, IPI]; mRNA catabolic process [GO:0006402, IDA]; small GTPase binding [GO:0031267, IPI]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; U2-type precatalytic spliceosome [GO:0071005, IDA]; precatalytic spliceosome [GO:0071011, IPI]; catalytic step 2 spliceosome [GO:0071013, IDA]; Lsm2-8 complex [GO:0120115, IDA]	Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snR
Q9Y4Y9	LSM5	91	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	0	U6 snRNA-associated Sm-like protein LSm5	76	47	14	5	2	26	0	CFP	1	1	1	GO:0000244;GO:0000290;GO:0000387;GO:0000398;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005688;GO:0005691;GO:0005737;GO:0005829;GO:0006397;GO:0006402;GO:0046540;GO:0046982;GO:0071001;GO:0071002;GO:0071005;GO:0071009;GO:0071011;GO:0120115;GO:1990726	mRNA splicing, via spliceosome [GO:0000398, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; spliceosomal complex [GO:0005681, IPI]; cytoplasm [GO:0005737, IDA]; cytoplasm [GO:0005737, IPI]; mRNA catabolic process [GO:0006402, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; protein heterodimerization activity [GO:0046982, IDA]; U2-type precatalytic spliceosome [GO:0071005, IDA]; precatalytic spliceosome [GO:0071011, IPI]; Lsm2-8 complex [GO:0120115, IDA]	Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snR
P62312	LSM6	80	other characterized small protein	Evidence at protein level	5.0	2004-07-05	0	0	U6 snRNA-associated Sm-like protein LSm6	104	55	15	8	7	25	0	CFP	1	1	1	GO:0000244;GO:0000290;GO:0000387;GO:0000398;GO:0000932;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005688;GO:0005691;GO:0005730;GO:0005732;GO:0005737;GO:0005829;GO:0006402;GO:0008380;GO:0030490;GO:0030532;GO:0046540;GO:0046982;GO:0071001;GO:0071002;GO:0071005;GO:0071009;GO:0071011;GO:0120115	mRNA splicing, via spliceosome [GO:0000398, IDA]; RNA binding [GO:0003723, HDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; spliceosomal complex [GO:0005681, IPI]; cytoplasm [GO:0005737, IDA]; cytoplasm [GO:0005737, IPI]; mRNA catabolic process [GO:0006402, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; protein heterodimerization activity [GO:0046982, IDA]; U2-type precatalytic spliceosome [GO:0071005, IDA]; precatalytic spliceosome [GO:0071011, IPI]; Lsm2-8 complex [GO:0120115, IDA]	Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snR
O95777	LSM8	96	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	0	U6 snRNA-associated Sm-like protein LSm8	67	43	12	5	5	21	0	CFP	1	1	1	GO:0000244;GO:0000387;GO:0000398;GO:0003723;GO:0003729;GO:0005634;GO:0005654;GO:0005681;GO:0005688;GO:0005691;GO:0017070;GO:0046540;GO:0071001;GO:0071002;GO:0071005;GO:0071009;GO:0071011;GO:0120115	mRNA splicing, via spliceosome [GO:0000398, IDA]; RNA binding [GO:0003723, HDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; spliceosomal complex [GO:0005681, IPI]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; U2-type precatalytic spliceosome [GO:0071005, IDA]; precatalytic spliceosome [GO:0071011, IPI]; Lsm2-8 complex [GO:0120115, IDA]	Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snR
O00453	LST1	97	other characterized small protein	Evidence at protein level	5.0	2003-08-22	0	1	Leukocyte-specific transcript 1 protein (Protein B144)	17	17	5	2	6	4	0	CP	0	1	1	GO:0000139;GO:0000902;GO:0005737;GO:0005794;GO:0005886;GO:0006955;GO:0009653;GO:0012505;GO:0016020;GO:0016358;GO:0050672	cytoplasm [GO:0005737, IDA]; plasma membrane [GO:0005886, IDA]; membrane [GO:0016020, IDA]; dendrite development [GO:0016358, IDA]; negative regulation of lymphocyte proliferation [GO:0050672, IDA]	Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Q538Z0	LUZP6	58	other characterized small protein	Evidence at protein level	2.0	2008-02-05	0	0	Leucine zipper protein 6 (Myeloproliferative disease-associated 6 kDa antigen)	0	0	0	0	0	0	0		0	0	0			
Q9NU23	LYRM2	88	other characterized small protein	Evidence at protein level	3.0	2006-10-03	0	0	LYR motif-containing protein 2	6	4	2	1	1	0	0	CP	0	1	1	GO:0005739;GO:0032981	mitochondrion [GO:0005739, HTP]; mitochondrial respiratory chain complex I assembly [GO:0032981, IMP]	Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I. {ECO:0000269|PubMed:31666358}.
Q9HD34	LYRM4	91	other characterized small protein	Evidence at protein level	5.0	2004-04-26	0	0	LYR motif-containing protein 4	38	31	15	4	4	8	0	CFP	1	1	1	GO:0005198;GO:0005634;GO:0005739;GO:0005759;GO:0016226;GO:0016604;GO:0042803;GO:0044571;GO:0044572;GO:0060090;GO:0099128;GO:1990221;GO:1990229	structural molecule activity [GO:0005198, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; nuclear body [GO:0016604, IDA]; protein homodimerization activity [GO:0042803, IDA]; [2Fe-2S] cluster assembly [GO:0044571, IDA]; molecular adaptor activity [GO:0060090, IDA]; mitochondrial [2Fe-2S] assembly complex [GO:0099128, IDA]	Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:17331979, PubMed:31664822). 
A8MSI8	LYRM9	78	other characterized small protein	Evidence at protein level	2.0	2008-07-22	0	0	LYR motif-containing protein 9	1	1	1	0	0	0	0	C	0	0	1	GO:0005739	mitochondrion [GO:0005739, HTP]	
Q9NQG1	MANBAL	85	other characterized small protein	Evidence at protein level	5.0	2003-04-30	0	1	Protein MANBAL	22	2	0	0	2	0	0		0	0	1	GO:0016020		
C9JLW8	MCRIP1	97	other characterized small protein	Evidence at protein level	5.0	2010-05-18	0	0	Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B)	13	9	5	0	2	2	0	CP	0	1	1	GO:0005634;GO:0005654;GO:0005737;GO:0010494;GO:0010717	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cytoplasmic stress granule [GO:0010494, IDA]; regulation of epithelial to mesenchymal transition [GO:0010717, IDA]	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing o
Q5JSS6	MEIG1	88	other characterized small protein	Evidence at protein level	2.0	2008-01-15	0	0	Meiosis expressed gene 1 protein homolog	3	2	0	1	1	0	0		0	0	1	GO:0005634		Essential for spermiogenesis. {ECO:0000250|UniProtKB:Q61845}.
Q13015	MLLT11	90	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	0	Protein AF1q	23	19	9	5	5	0	0	CP	0	1	1	GO:0005634;GO:0005654;GO:0005737;GO:0005739;GO:0005813;GO:0005829;GO:0043065;GO:0045893;GO:0051901;GO:0090200;GO:0097190;GO:0097191;GO:0097193	nucleoplasm [GO:0005654, IDA]; mitochondrion [GO:0005739, HTP]; cytosol [GO:0005829, IDA]; positive regulation of apoptotic process [GO:0043065, IMP]; positive regulation of DNA-templated transcription [GO:0045893, IDA]; positive regulation of mitochondrial depolarization [GO:0051901, IDA]; positive regulation of release of cytochrome c from mitochondria [GO:0090200, IDA]; extrinsic apoptotic signaling pathway [GO:0097191, IDA]; intrinsic apoptotic signaling pathway [GO:0097193, IDA]	Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}.
O96033	MOCS2	88	other characterized small protein	Evidence at protein level	5.0	2002-02-11	0	0	Molybdopterin synthase sulfur carrier subunit (MOCO1-A) (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Molybdopterin-synthase small subunit) (Sulfur carrier protein MOCS2A)	24	21	11	0	8	2	0	CFP	1	1	1	GO:0005634;GO:0005829;GO:0006777;GO:0030366;GO:1990140	cytosol [GO:0005829, IDA]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777, IDA]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777, IMP]; molybdopterin synthase activity [GO:0030366, IDA]; molybdopterin synthase complex [GO:1990140, IDA]; molybdopterin synthase complex [GO:1990140, IPI]	Acts as a sulfur carrier required for molybdopterin biosynthesis (PubMed:22453920). Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the
Q502X0	MORN2	79	other characterized small protein	Evidence at protein level	2.0	2006-07-25	0	0	MORN repeat-containing protein 2 (MORN motif protein in testis)	4	3	0	0	2	1	0		0	0	1	GO:0001669;GO:0005634		Might have a role in spermatogenesis. {ECO:0000250|UniProtKB:Q6UL01}.
Q08AG7	MZT1	82	other characterized small protein	Evidence at protein level	5.0	2008-05-20	0	0	Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)	26	19	4	6	4	5	0	CP	0	1	1	GO:0000930;GO:0000931;GO:0005813;GO:0005819;GO:0005829;GO:0007020;GO:0031021;GO:0033566;GO:0051415;GO:0090307	gamma-tubulin ring complex [GO:0000931, IDA]; centrosome [GO:0005813, IDA]; spindle [GO:0005819, IDA]; gamma-tubulin complex localization [GO:0033566, IMP]	Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in
Q69YL0	NCBP2AS2	99	other characterized small protein	Evidence at protein level	3.0	2009-04-14	0	0	Protein NCBP2AS2 (Hypoxia-induced angiogenesis regulator) (NCBP2 antisense gene protein 2)	6	1	1	0	0	0	0	C	0	0	1	GO:0005739	mitochondrion [GO:0005739, HTP]	
Q15843	NEDD8	81	other characterized small protein	Evidence at protein level	5.0	1997-11-01	0	0	Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)	98	52	5	6	7	34	0	CFP	1	1	1	GO:0005634;GO:0005654;GO:0005737;GO:0005829;GO:0006508;GO:0006511;GO:0009653;GO:0019941;GO:0030162;GO:0031386;GO:0031625;GO:0036211;GO:0045116;GO:0070062;GO:0072757;GO:0098794;GO:0098978;GO:0150052	nucleoplasm [GO:0005654, IDA]; ubiquitin protein ligase binding [GO:0031625, IPI]; protein neddylation [GO:0045116, IDA]; protein neddylation [GO:0045116, IMP]; extracellular exosome [GO:0070062, HDA]	Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:14690597, PubMed:15242646, PubMed:9694792, PubMed:38605244
Q16517	NNAT	81	other characterized small protein	Evidence at protein level	3.0	1997-11-01	0	0	Neuronatin	5	5	0	2	1	2	0		0	1	1	GO:0005737;GO:0007420;GO:0009249;GO:0032024		May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.
Q9NPE3	NOP10	64	other characterized small protein	Evidence at protein level	5.0	2004-10-11	0	0	H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)	50	40	10	4	7	19	0	CFP	1	1	1	GO:0000454;GO:0001522;GO:0003723;GO:0005654;GO:0005697;GO:0005730;GO:0005732;GO:0007004;GO:0015030;GO:0016604;GO:0030515;GO:0031118;GO:0031120;GO:0031429;GO:0034513;GO:0042254;GO:0070034;GO:0072589;GO:0090661;GO:0090671	RNA binding [GO:0003723, IPI]; telomerase holoenzyme complex [GO:0005697, IDA]; telomere maintenance via telomerase [GO:0007004, IDA]; nuclear body [GO:0016604, IDA]; box H/ACA snoRNP complex [GO:0031429, IDA]; box H/ACA snoRNA binding [GO:0034513, IPI]; telomerase RNA binding [GO:0070034, IPI]; box H/ACA telomerase RNP complex [GO:0090661, IDA]; telomerase RNA localization to Cajal body [GO:0090671, HMP]	Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead 
Q16612	NREP	68	other characterized small protein	Evidence at protein level	5.0	1997-11-01	0	0	Neuronal regeneration-related protein (Neuronal protein 3.1) (Protein p311)	7	6	0	3	3	0	0		0	1	1	GO:0005737;GO:0017015;GO:0031103;GO:0045664		May have roles in neural function. Ectopic expression augments motility of gliomas. Also promotes axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. In
Q92686	NRGN	78	other characterized small protein	Evidence at protein level	5.0	1997-11-01	0	0	Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)]	21	21	0	0	17	4	0		1	1	1	GO:0005516;GO:0005547;GO:0005829;GO:0007165;GO:0007399;GO:0008306;GO:0012510;GO:0021537;GO:0030424;GO:0030425;GO:0031966;GO:0043025;GO:0044327;GO:0045211;GO:0070300;GO:0098794;GO:0098978;GO:0099170;GO:1900273		Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}.
O60356	NUPR1	82	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	0	Nuclear protein 1 (Candidate of metastasis 1) (Protein p8)	67	55	23	3	17	12	0	CFP	1	1	1	GO:0003677;GO:0003682;GO:0003713;GO:0005634;GO:0005654;GO:0005737;GO:0008285;GO:0010506;GO:0010507;GO:0010667;GO:0010698;GO:0032993;GO:0043066;GO:0043525;GO:0045786;GO:0045787;GO:0045820;GO:0045893;GO:0048471;GO:0050680;GO:0062099;GO:0150078;GO:1901800;GO:1902902;GO:1903862;GO:1904036;GO:1904691;GO:1905897;GO:2001244	DNA binding [GO:0003677, EXP]; DNA binding [GO:0003677, IDA]; transcription coactivator activity [GO:0003713, IMP]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; cytoplasm [GO:0005737, IDA]; negative regulation of autophagy [GO:0010507, IMP]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667, IMP]; protein-DNA complex [GO:0032993, IDA]; negative regulation of apoptotic process [GO:0043066, IMP]; negative regulation of cell cycle [GO:0045786, IMP]; positive regulation of cell cycle [GO:0045787, IDA]; negative regulation of glycolysis [GO:0045820, IMP]; perinuclear region of cytoplasm [GO:0048471, IDA]; negative regulation of programmed necrotic cell death [GO:0062099, IMP]; positive regulation of proteasomal protein catabolic process [GO:1901800, IMP]; negative regulation of autophagosome assembly [GO:1902902, IMP]; positive regulation of oxidative phosphorylation [GO:1903862, IMP]; regulation of response to endoplasmic reticulum stress [GO:1905897, IMP]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244, IMP]	Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair resp
A6NF83	NUPR2	97	other characterized small protein	Evidence at protein level	4.0	2008-09-02	0	0	Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2)	11	11	6	4	1	0	0	CP	0	1	1	GO:0000122;GO:0005634;GO:0006357;GO:0006974;GO:0008285;GO:0009267;GO:0045786;GO:0051726	negative regulation of transcription by RNA polymerase II [GO:0000122, IDA]; nucleus [GO:0005634, IDA]; DNA damage response [GO:0006974, IDA]; negative regulation of cell population proliferation [GO:0008285, IDA]; cellular response to starvation [GO:0009267, IDA]; regulation of cell cycle [GO:0051726, IDA]	Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells (PubMed:25899918). Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation (PubMed:25899918). Plays a role as a negative reg
Q8TAD7	OCC1	63	other characterized small protein	Evidence at protein level	2.0	2009-04-14	0	0	Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3)	0	0	0	0	0	0	0		0	0	0			
Q9BZK8	OCR1	76	other characterized small protein	Predicted	1.0	2008-09-02	0	0	Ovarian cancer-related protein 1	0	0	0	0	0	0	0		0	0	0			
P0C6T2	OST4	37	other characterized small protein	Evidence at protein level	5.0	2008-04-08	0	1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4	24	22	8	2	2	10	0	CP	0	1	1	GO:0005783;GO:0005789;GO:0006487;GO:0008250;GO:0160226;GO:0160227	protein N-linked glycosylation [GO:0006487, IDA]; protein N-linked glycosylation [GO:0006487, IMP]; oligosaccharyltransferase complex [GO:0008250, IDA]; oligosaccharyltransferase complex [GO:0008250, IPI]; oligosaccharyltransferase complex A [GO:0160226, IDA]; oligosaccharyltransferase complex B [GO:0160227, IDA]	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the firs
P01358		10	other characterized small protein	Evidence at protein level	1.0	1986-07-21	0	0	Gastric juice peptide 1 [Cleaved into: Gastric juice peptide 2]	0	0	0	0	0	0	0		0	0	0			
P01858		4	other characterized small protein	Evidence at protein level	1.0	1986-07-21	0	0	Phagocytosis-stimulating peptide (Tuftsin)	0	0	0	0	0	0	0		0	0	0			
P02728		10	other characterized small protein	Evidence at protein level	2.0	1986-07-21	0	0	Erythrocyte membrane glycopeptide	0	0	0	0	0	0	0		0	0	0			
P02729		8	other characterized small protein	Evidence at protein level	2.0	1986-07-21	0	0	Urine glycopeptide	0	0	0	0	0	0	0		0	0	0			
P22103		10	other characterized small protein	Evidence at protein level	2.0	1991-08-01	0	0	Pneumadin (PNM)	0	0	0	0	0	0	0		0	0	0			Antidiuretic peptide that triggers the release of ADH.
P69208		11	other characterized small protein	Evidence at protein level	4.0	1986-07-21	0	0	Morphogenetic neuropeptide (Head activator) (HA)	0	0	0	0	0	0	0		0	0	0			Stimulates the proliferation of neural cells. {ECO:0000269|PubMed:11082041}.
P48539	PCP4	62	other characterized small protein	Evidence at protein level	5.0	1996-02-01	0	0	Calmodulin regulator protein PCP4 (Brain-specific polypeptide PEP-19) (Purkinje cell protein 4)	13	11	8	3	0	0	0	CFP	1	1	1	GO:0005509;GO:0005516;GO:0005634;GO:0005737;GO:0005829;GO:0032991;GO:0045666;GO:1905291	calcium ion binding [GO:0005509, IDA]; calmodulin binding [GO:0005516, IDA]; calmodulin binding [GO:0005516, IPI]; nucleus [GO:0005634, HDA]; cytosol [GO:0005829, HDA]; protein-containing complex [GO:0032991, IDA]; positive regulation of neuron differentiation [GO:0045666, IMP]; positive regulation of CAMKK-AMPK signaling cascade [GO:1905291, IMP]	Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase s
A6NKN8	PCP4L1	68	other characterized small protein	Evidence at protein level	2.0	2008-04-29	0	0	Purkinje cell protein 4-like protein 1 (PCP4-like protein 1)	0	0	0	0	0	0	0		0	0	0			
P18545	PDE6G	87	other characterized small protein	Evidence at protein level	5.0	1990-11-01	0	0	Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma (Rod GMP-PDE gamma)	26	18	1	3	5	9	0	P	1	1	1	GO:0001750;GO:0004114;GO:0004857;GO:0005886;GO:0007601;GO:0030507;GO:0030553;GO:0042622;GO:0045742;GO:0045745;GO:0097381;GO:7770030	visual perception [GO:0007601, IDA]	Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma sub
Q13956	PDE6H	83	other characterized small protein	Evidence at protein level	4.0	1997-11-01	0	0	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (Cone GMP-PDE gamma)	18	11	0	3	5	3	0		1	1	1	GO:0004114;GO:0004857;GO:0007601;GO:0030553;GO:0042622;GO:0045742;GO:0045745;GO:0047555		Inhibitory gamma subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H) (By similarity). Ligh
P0DJ07	PET100	73	other characterized small protein	Evidence at protein level	4.0	2011-10-19	0	1	Protein PET100 homolog, mitochondrial	9	9	2	2	5	0	0	C	0	1	1	GO:0005739;GO:0005743;GO:0016020;GO:0033617	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, EXP]	Plays an essential role in mitochondrial complex IV maturation and assembly. {ECO:0000269|PubMed:24462369, ECO:0000269|PubMed:25293719}.
Q6UWS5	PET117	81	other characterized small protein	Evidence at protein level	3.0	2012-03-21	0	0	Protein PET117 homolog, mitochondrial	5	5	2	2	1	0	0	C	0	1	1	GO:0005739;GO:0033617	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	
C9JFL3	PHGR1	82	other characterized small protein	Evidence at protein level	1.0	2010-06-15	0	0	Proline, histidine and glycine-rich protein 1	0	0	0	0	0	0	0		0	0	0			
Q3MUY2	PIGY	71	other characterized small protein	Evidence at protein level	5.0	2006-07-25	0	1	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (Phosphatidylinositol-glycan biosynthesis class Y protein) (PIG-Y)	16	12	7	2	2	1	0	CFP	1	1	1	GO:0000506;GO:0005789;GO:0005886;GO:0006506;GO:0017176	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506, IDA]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506, IPI]; endoplasmic reticulum membrane [GO:0005789, IDA]; plasma membrane [GO:0005886, IDA]; GPI anchor biosynthetic process [GO:0006506, IDA]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176, IDA]	Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the catal
P61925	PKIA	76	other characterized small protein	Evidence at protein level	5.0	1987-08-13	0	0	cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform)	24	15	6	3	5	1	0	FP	1	1	1	GO:0004862;GO:0005634;GO:0005737;GO:0034236;GO:0141162;GO:2000480	cAMP-dependent protein kinase inhibitor activity [GO:0004862, IDA]; protein kinase A catalytic subunit binding [GO:0034236, IPI]; negative regulation of cAMP/PKA signal transduction [GO:0141162, IDA]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480, IDA]	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Q9C010	PKIB	78	other characterized small protein	Evidence at protein level	3.0	2001-09-26	0	0	cAMP-dependent protein kinase inhibitor beta (PKI-beta)	7	5	1	3	1	0	0	P	1	1	1	GO:0004862;GO:0005634;GO:0005737;GO:0032206	positive regulation of telomere maintenance [GO:0032206, IMP]	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.
Q9Y2B9	PKIG	76	other characterized small protein	Evidence at protein level	3.0	2000-05-30	0	0	cAMP-dependent protein kinase inhibitor gamma (PKI-gamma)	7	5	0	3	1	1	0		1	0	1	GO:0004862;GO:0005634;GO:0005737		Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.
P26678	PLN	52	other characterized small protein	Evidence at protein level	5.0	1992-08-01	0	1	Phospholamban (PLB)	146	83	22	5	28	28	0	CFP	1	1	1	GO:0001675;GO:0002026;GO:0004857;GO:0005739;GO:0005783;GO:0005789;GO:0006816;GO:0006874;GO:0007283;GO:0008015;GO:0008016;GO:0008542;GO:0010043;GO:0010459;GO:0016020;GO:0016529;GO:0031966;GO:0031982;GO:0032868;GO:0032991;GO:0033017;GO:0033574;GO:0042030;GO:0042802;GO:0042803;GO:0044325;GO:0045475;GO:0048471;GO:0050802;GO:0051117;GO:0051480;GO:0051924;GO:0051926;GO:0055119;GO:0086004;GO:0086036;GO:0090281;GO:0090534;GO:0141110;GO:1901894;GO:1901895;GO:1901897;GO:1902081;GO:1990629	mitochondrion [GO:0005739, HDA]; endoplasmic reticulum membrane [GO:0005789, EXP]; regulation of heart contraction [GO:0008016, IMP]; negative regulation of heart rate [GO:0010459, IMP]; membrane [GO:0016020, IDA]; sarcoplasmic reticulum membrane [GO:0033017, EXP]; ATPase inhibitor activity [GO:0042030, IDA]; transmembrane transporter binding [GO:0044325, IPI]; regulation of cytosolic calcium ion concentration [GO:0051480, IDA]; regulation of calcium ion transport [GO:0051924, IDA]; negative regulation of calcium ion transport [GO:0051926, IDA]; regulation of cardiac muscle cell contraction [GO:0086004, IDA]; calcium ion-transporting ATPase complex [GO:0090534, IDA]; transporter inhibitor activity [GO:0141110, IDA]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894, IDA]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895, IDA]; negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081, IDA]; phospholamban complex [GO:1990629, IPI]	Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diasto
Q13794	PMAIP1	54	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	0	Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)	60	48	34	1	5	8	0	CP	0	1	1	GO:0001836;GO:0005634;GO:0005739;GO:0005741;GO:0005829;GO:0006915;GO:0006974;GO:0010498;GO:0010907;GO:0010917;GO:0042149;GO:0043029;GO:0043065;GO:0043331;GO:0043517;GO:0046902;GO:0051607;GO:0071456;GO:0072332;GO:0072593;GO:0090200;GO:0097136;GO:0097193;GO:1902043;GO:1902237;GO:2001244	nucleus [GO:0005634, IDA]; mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; cytosol [GO:0005829, IDA]; apoptotic process [GO:0006915, IMP]; proteasomal protein catabolic process [GO:0010498, IDA]; positive regulation of glucose metabolic process [GO:0010907, IDA]; cellular response to glucose starvation [GO:0042149, IMP]; positive regulation of apoptotic process [GO:0043065, IDA]; positive regulation of apoptotic process [GO:0043065, IMP]; response to dsRNA [GO:0043331, IDA]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517, IMP]; regulation of mitochondrial membrane permeability [GO:0046902, IDA]; defense response to virus [GO:0051607, IDA]; cellular response to hypoxia [GO:0071456, IEP]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332, IMP]; reactive oxygen species metabolic process [GO:0072593, IDA]; positive regulation of release of cytochrome c from mitochondria [GO:0090200, IDA]; positive regulation of release of cytochrome c from mitochondria [GO:0090200, IMP]; Bcl-2 family protein complex [GO:0097136, IPI]; intrinsic apoptotic signaling pathway [GO:0097193, IDA]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043, IDA]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244, IDA]	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and 
P53803	POLR2K	58	other characterized small protein	Evidence at protein level	5.0	1996-10-01	0	0	DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)	171	170	23	4	7	136	0	CP	1	1	1	GO:0001650;GO:0003677;GO:0003899;GO:0005634;GO:0005654;GO:0005665;GO:0005666;GO:0005730;GO:0005736;GO:0005829;GO:0006351;GO:0006356;GO:0006361;GO:0006362;GO:0006363;GO:0006366;GO:0006367;GO:0006368;GO:0006383;GO:0006384;GO:0006386;GO:0008270;GO:0042790	fibrillar center [GO:0001650, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; RNA polymerase II, core complex [GO:0005665, IDA]; RNA polymerase II, core complex [GO:0005665, IPI]; RNA polymerase III complex [GO:0005666, IDA]; RNA polymerase III complex [GO:0005666, IPI]; RNA polymerase I complex [GO:0005736, IDA]; RNA polymerase I complex [GO:0005736, IPI]; transcription elongation by RNA polymerase I [GO:0006362, IDA]; transcription by RNA polymerase II [GO:0006366, IDA]; transcription initiation at RNA polymerase II promoter [GO:0006367, IDA]; transcription elongation by RNA polymerase II [GO:0006368, IDA]; transcription by RNA polymerase III [GO:0006383, IDA]; transcription initiation at RNA polymerase III promoter [GO:0006384, IDA]; termination of RNA polymerase III transcription [GO:0006386, IDA]	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such
P62875	POLR2L	67	other characterized small protein	Evidence at protein level	5.0	2004-08-16	0	0	DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)	198	175	25	8	8	134	0	CFP	1	1	1	GO:0003677;GO:0003899;GO:0005634;GO:0005654;GO:0005665;GO:0005666;GO:0005730;GO:0005736;GO:0005829;GO:0006351;GO:0006356;GO:0006360;GO:0006361;GO:0006362;GO:0006363;GO:0006366;GO:0006367;GO:0006368;GO:0006383;GO:0006384;GO:0006386;GO:0008270;GO:0042790;GO:0042797	nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; RNA polymerase II, core complex [GO:0005665, IDA]; RNA polymerase II, core complex [GO:0005665, IPI]; RNA polymerase III complex [GO:0005666, IDA]; RNA polymerase III complex [GO:0005666, IPI]; RNA polymerase I complex [GO:0005736, IDA]; RNA polymerase I complex [GO:0005736, IPI]; transcription elongation by RNA polymerase I [GO:0006362, IDA]; transcription by RNA polymerase II [GO:0006366, IDA]; transcription initiation at RNA polymerase II promoter [GO:0006367, IDA]; transcription elongation by RNA polymerase II [GO:0006368, IDA]; transcription by RNA polymerase III [GO:0006383, IDA]; transcription initiation at RNA polymerase III promoter [GO:0006384, IDA]; termination of RNA polymerase III transcription [GO:0006386, IDA]; zinc ion binding [GO:0008270, IDA]	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such
Q8WWR9	PPDPFL	84	other characterized small protein	Evidence at protein level	2.0	2006-03-21	0	0	Pancreatic progenitor cell differentiation and proliferation factor-like protein (Exocrine differentiation and proliferation factor-like protein)	1	1	0	0	1	0	0		0	1	0	GO:0030154		
Q96KF2	PRAC1	57	other characterized small protein	Evidence at transcript level	2.0	2007-12-04	0	0	Small nuclear protein PRAC1 (Prostate cancer susceptibility candidate protein 1) (Prostate, rectum and colon expressed gene protein)	2	2	1	0	1	0	0	C	0	0	1	GO:0005634;GO:0005654	nucleoplasm [GO:0005654, IDA]	
Q00LT1	PRCD	54	other characterized small protein	Evidence at protein level	5.0	2007-03-20	0	0	Photoreceptor disk component PRCD (Progressive rod-cone degeneration protein)	17	17	7	2	8	0	0	CP	1	1	1	GO:0001750;GO:0002046;GO:0005576;GO:0005737;GO:0005783;GO:0005794;GO:0016020;GO:0042622;GO:0050908	extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, IDA]; endoplasmic reticulum [GO:0005783, IDA]; Golgi apparatus [GO:0005794, IDA]; membrane [GO:0016020, EXP]; photoreceptor outer segment membrane [GO:0042622, IDA]; detection of light stimulus involved in visual perception [GO:0050908, IMP]	Involved in vision. {ECO:0000269|PubMed:16938425, ECO:0000269|PubMed:24992209}.
P04553	PRM1	51	other characterized small protein	Evidence at protein level	5.0	1987-08-13	0	0	Sperm protamine P1 (Cysteine-rich protamine)	14	13	2	0	7	4	0	C	1	1	1	GO:0000786;GO:0003677;GO:0005634;GO:0005654;GO:0005694;GO:0005829;GO:0007283;GO:0035092;GO:0051276	nucleoplasm [GO:0005654, IDA]; cytosol [GO:0005829, IDA]	Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
F7VJQ1	PRNP	73	other characterized small protein	Evidence at protein level	3.0	2012-11-28	0	1	Alternative prion protein (AltPrP)	2	2	1	0	1	0	0	C	0	0	1	GO:0005741	mitochondrial outer membrane [GO:0005741, IDA]	
Q8WXC3	PYDC1	89	other characterized small protein	Evidence at protein level	5.0	2007-03-20	0	0	Pyrin domain-containing protein 1 (PAAD-only protein 1) (Pyrin-only protein 1) (cellular POP1) (cPOP1)	22	21	12	0	9	0	0	CFP	1	1	1	GO:0002376;GO:0005634;GO:0005737;GO:0005829;GO:0006952;GO:0008385;GO:0010803;GO:0010804;GO:0030291;GO:0032731;GO:0043124;GO:0045087;GO:0051707;GO:0120283;GO:2000660	nucleus [GO:0005634, IDA]; cytosol [GO:0005829, IDA]; IkappaB kinase complex [GO:0008385, IDA]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804, IDA]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804, IMP]; protein serine/threonine kinase inhibitor activity [GO:0030291, IDA]; positive regulation of interleukin-1 beta production [GO:0032731, IGI]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124, IDA]; innate immune response [GO:0045087, IDA]; protein serine/threonine kinase binding [GO:0120283, IPI]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660, IDA]	Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by 
Q56P42	PYDC2	97	other characterized small protein	Evidence at protein level	5.0	2008-09-02	0	0	Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)	23	21	16	0	5	0	0	CP	0	1	1	GO:0005634;GO:0005654;GO:0005730;GO:0005737;GO:0005829;GO:0010804;GO:0032651;GO:0032691;GO:0050728;GO:1900226;GO:1901223	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; nucleolus [GO:0005730, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804, IMP]; negative regulation of interleukin-1 beta production [GO:0032691, IMP]; negative regulation of inflammatory response [GO:0050728, IMP]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226, IMP]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223, IMP]	May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17178784, PubMed:17339483). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). {E
Q8N0T1	RBIS	100	other characterized small protein	Evidence at protein level	4.0	2008-03-18	0	0	Ribosomal biogenesis factor	9	8	4	2	2	0	0	CP	0	1	1	GO:0005654;GO:0005730;GO:0042254	nucleoplasm [GO:0005654, IDA]; nucleolus [GO:0005730, IDA]; ribosome biogenesis [GO:0042254, IMP]	Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. {ECO:0000269|PubMed:26711351}.
A6NNX1	RIIAD1	92	other characterized small protein	Evidence at protein level	1.0	2008-07-01	0	0	RIIa domain-containing protein 1	0	0	0	0	0	0	0		0	0	0			
P23297	S100A1	94	other characterized small protein	Evidence at protein level	5.0	1991-11-01	0	0	Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)	84	53	17	5	6	25	0	CFP	1	1	1	GO:0005509;GO:0005576;GO:0005634;GO:0005737;GO:0005739;GO:0005829;GO:0008016;GO:0016529;GO:0021762;GO:0032991;GO:0035556;GO:0042311;GO:0042802;GO:0042803;GO:0044548;GO:0048306;GO:0051117;GO:1903672	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, EXP]; cytosol [GO:0005829, IDA]; sarcoplasmic reticulum [GO:0016529, IDA]; substantia nigra development [GO:0021762, HEP]; vasodilation [GO:0042311, IDA]; identical protein binding [GO:0042802, IPI]; protein homodimerization activity [GO:0042803, IDA]; S100 protein binding [GO:0044548, IPI]; ATPase binding [GO:0051117, IPI]; positive regulation of sprouting angiogenesis [GO:1903672, IDA]	Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (Pub
P60903	S100A10	97	other characterized small protein	Evidence at protein level	5.0	1988-08-01	0	0	Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)	54	35	20	4	7	4	0	CFP	1	1	1	GO:0001765;GO:0005509;GO:0005576;GO:0005737;GO:0005886;GO:0006900;GO:0009986;GO:0010756;GO:0016363;GO:0031012;GO:0042789;GO:0042803;GO:0043547;GO:0044325;GO:0045121;GO:0045921;GO:0045944;GO:0048306;GO:0050767;GO:0051496;GO:0051894;GO:0070062;GO:0072659;GO:0090575;GO:0098797;GO:1900026;GO:1905686;GO:1990665	membrane raft assembly [GO:0001765, IDA]; extracellular region [GO:0005576, HDA]; plasma membrane [GO:0005886, IDA]; vesicle budding from membrane [GO:0006900, IDA]; positive regulation of plasminogen activation [GO:0010756, IDA]; extracellular matrix [GO:0031012, HDA]; protein homodimerization activity [GO:0042803, IDA]; positive regulation of GTPase activity [GO:0043547, IMP]; transmembrane transporter binding [GO:0044325, IPI]; membrane raft [GO:0045121, IDA]; positive regulation of stress fiber assembly [GO:0051496, IMP]; positive regulation of focal adhesion assembly [GO:0051894, IMP]; extracellular exosome [GO:0070062, HDA]; protein localization to plasma membrane [GO:0072659, IDA]; RNA polymerase II transcription regulator complex [GO:0090575, EXP]; plasma membrane protein complex [GO:0098797, IPI]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026, IMP]; AnxA2-p11 complex [GO:1990665, IDA]	Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
P29034	S100A2	98	other characterized small protein	Evidence at protein level	5.0	1992-12-01	0	0	Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)	33	12	5	3	3	1	0	FP	1	1	0	GO:0005509;GO:0042802;GO:0043542;GO:0046914;GO:0048306	identical protein binding [GO:0042802, IPI]; endothelial cell migration [GO:0043542, IMP]	May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. {ECO:0000269|
P33763	S100A5	92	other characterized small protein	Evidence at protein level	5.0	1994-02-01	0	0	Protein S100-A5 (Protein S-100D) (S100 calcium-binding protein A5)	19	12	5	3	4	0	0	CF	1	0	1	GO:0005507;GO:0005509;GO:0005634;GO:0008270;GO:0042802;GO:0042803;GO:0043025;GO:0046914;GO:0048306	copper ion binding [GO:0005507, IDA]; calcium ion binding [GO:0005509, IDA]; nucleus [GO:0005634, IDA]; zinc ion binding [GO:0008270, IDA]; protein homodimerization activity [GO:0042803, IPI]	Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. {ECO:0000269|PubMed:10882717}.
P06703	S100A6	90	other characterized small protein	Evidence at protein level	5.0	1988-01-01	0	0	Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)	63	43	22	5	10	6	0	CF	1	1	1	GO:0001726;GO:0005509;GO:0005523;GO:0005576;GO:0005634;GO:0005635;GO:0005737;GO:0005829;GO:0005886;GO:0007165;GO:0007409;GO:0008270;GO:0009898;GO:0015075;GO:0031012;GO:0034220;GO:0042802;GO:0042803;GO:0044548;GO:0048146;GO:0048306;GO:0048471;GO:0070062	ruffle [GO:0001726, IDA]; calcium ion binding [GO:0005509, IDA]; tropomyosin binding [GO:0005523, IDA]; extracellular region [GO:0005576, HDA]; nucleus [GO:0005634, IDA]; nuclear envelope [GO:0005635, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; plasma membrane [GO:0005886, IDA]; cytoplasmic side of plasma membrane [GO:0009898, IDA]; extracellular matrix [GO:0031012, HDA]; protein homodimerization activity [GO:0042803, IDA]; protein homodimerization activity [GO:0042803, IPI]; S100 protein binding [GO:0044548, IPI]; calcium-dependent protein binding [GO:0048306, IDA]; perinuclear region of cytoplasm [GO:0048471, IDA]; extracellular exosome [GO:0070062, HDA]	May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell moti
P29377	S100G	79	other characterized small protein	Evidence at protein level	3.0	1992-12-01	0	0	Protein S100-G (Calbindin-D9k) (S100 calcium-binding protein G) (Vitamin D-dependent calcium-binding protein, intestinal) (CABP)	9	8	0	3	4	1	0		1	0	1	GO:0005509;GO:0005737;GO:0016323;GO:0016324;GO:0046914;GO:0048306		
P25815	S100P	95	other characterized small protein	Evidence at protein level	5.0	1992-05-01	0	0	Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)	53	23	8	4	6	5	0	CFP	1	1	1	GO:0000287;GO:0005509;GO:0005576;GO:0005634;GO:0005654;GO:0005737;GO:0031528;GO:0034774;GO:0042802;GO:0042803;GO:0043542;GO:0045296;GO:0046914;GO:0048306;GO:0070062	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; cytoplasm [GO:0005737, IDA]; protein homodimerization activity [GO:0042803, IDA]; endothelial cell migration [GO:0043542, IMP]; cadherin binding [GO:0045296, HDA]; calcium-dependent protein binding [GO:0048306, IPI]; extracellular exosome [GO:0070062, HDA]	May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate 
Q8WXG8	S100Z	99	other characterized small protein	Evidence at protein level	5.0	2002-04-16	0	0	Protein S100-Z (S100 calcium-binding protein Z)	17	6	2	2	2	0	0	F	1	0	0	GO:0005509;GO:0042802;GO:0042803;GO:0048306	calcium ion binding [GO:0005509, IDA]; protein homodimerization activity [GO:0042803, IDA]	
P60468	SEC61B	96	other characterized small protein	Evidence at protein level	5.0	2004-02-16	0	1	Protein transport protein Sec61 subunit beta	42	30	15	5	6	4	0	CFP	1	1	1	GO:0003723;GO:0005085;GO:0005783;GO:0005784;GO:0005789;GO:0005829;GO:0006616;GO:0006886;GO:0016020;GO:0030970;GO:0031204;GO:0031205;GO:0036503;GO:0043022;GO:0044322;GO:0048408	RNA binding [GO:0003723, HDA]; endoplasmic reticulum [GO:0005783, IDA]; Sec61 translocon complex [GO:0005784, IDA]; Sec61 translocon complex [GO:0005784, IPI]; endoplasmic reticulum membrane [GO:0005789, EXP]; endoplasmic reticulum membrane [GO:0005789, IDA]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616, IDA]; membrane [GO:0016020, IDA]; retrograde protein transport, ER to cytosol [GO:0030970, IMP]; ERAD quality control pathway [GO:0036503, IDA]; ribosome binding [GO:0043022, IDA]; endoplasmic reticulum quality control compartment [GO:0044322, IDA]; epidermal growth factor binding [GO:0048408, IPI]	Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational transl
P60059	SEC61G	68	other characterized small protein	Evidence at protein level	5.0	2003-11-21	0	1	Protein transport protein Sec61 subunit gamma	27	18	6	3	6	3	0	CFP	1	1	1	GO:0005784;GO:0005789;GO:0005829;GO:0006605;GO:0006616;GO:0006886;GO:0008320;GO:0015031;GO:0016020;GO:0031204;GO:0043022;GO:0045047;GO:0071261	Sec61 translocon complex [GO:0005784, IDA]; Sec61 translocon complex [GO:0005784, IPI]; endoplasmic reticulum membrane [GO:0005789, EXP]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616, IDA]; membrane [GO:0016020, IDA]; ribosome binding [GO:0043022, IDA]	Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational transloc
Q9Y6D0	SELENOK	94	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	1	Selenoprotein K (SelK)	53	24	11	4	9	0	0	CFP	1	1	1	GO:0002230;GO:0005783;GO:0005789;GO:0005794;GO:0005886;GO:0006816;GO:0006979;GO:0018345;GO:0032469;GO:0032722;GO:0032755;GO:0032760;GO:0042802;GO:0050848;GO:0070059;GO:0071639	endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum membrane [GO:0005789, EXP]; endoplasmic reticulum membrane [GO:0005789, IDA]; plasma membrane [GO:0005886, EXP]; response to oxidative stress [GO:0006979, IMP]; protein palmitoylation [GO:0018345, IDA]; identical protein binding [GO:0042802, IPI]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059, IMP]	Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface e
P63302	SELENOW	87	other characterized small protein	Evidence at protein level	3.0	2004-10-11	0	0	Selenoprotein W (SelW)	3	3	0	2	1	0	0		0	1	1	GO:0005737;GO:0005829;GO:0030218		Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity). {ECO:0000250}.
P60896	SEM1	70	other characterized small protein	Evidence at protein level	5.0	2004-04-13	0	0	26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)	145	121	7	0	4	110	0	CF	1	1	1	GO:0000502;GO:0005634;GO:0005654;GO:0005829;GO:0006406;GO:0006979;GO:0008021;GO:0008541;GO:0010498;GO:0032039;GO:0032991;GO:0043130;GO:0043161;GO:0043248;GO:0045944;GO:0061136;GO:0070390;GO:0071357	proteasome complex [GO:0000502, IDA]; nucleus [GO:0005634, EXP]; integrator complex [GO:0032039, IDA]; protein-containing complex [GO:0032991, IDA]; ubiquitin binding [GO:0043130, EXP]; transcription export complex 2 [GO:0070390, IPI]	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing prote
P84101	SERF2	59	other characterized small protein	Evidence at protein level	4.0	2004-08-16	0	0	Small EDRK-rich factor 2 (Gastric cancer-related protein VRG107) (Protein 4F5-related) (4F5rel) (h4F5rel)	3	3	1	0	0	2	0	P	0	1	1	GO:0005634;GO:0005829;GO:0031648	protein destabilization [GO:0031648, IMP]	Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (PubMed:20723760). {ECO:0000269|PubMed:20723760}.
Q9Y6X1	SERP1	66	other characterized small protein	Evidence at protein level	5.0	2007-02-06	0	1	Stress-associated endoplasmic reticulum protein 1 (Ribosome-attached membrane protein 4)	58	15	1	2	3	9	0	C	0	1	1	GO:0005783;GO:0005789;GO:0005829;GO:0005840;GO:0005881;GO:0007009;GO:0009101;GO:0016020;GO:0030968;GO:0036211	cytoplasmic microtubule [GO:0005881, IDA]	Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites
Q8N6R1	SERP2	65	other characterized small protein	Evidence at protein level	5.0	2007-02-06	0	1	Stress-associated endoplasmic reticulum protein 2 (Ribosome-associated membrane protein RAMP4-2)	56	7	0	2	3	2	0		0	1	1	GO:0005783;GO:0005789;GO:0016020;GO:0030968		Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites
Q9BWJ5	SF3B5	86	other characterized small protein	Evidence at protein level	5.0	2002-02-11	0	0	Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)	86	79	31	3	2	43	0	CFP	1	1	1	GO:0000124;GO:0000387;GO:0000388;GO:0000398;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005684;GO:0005686;GO:0005689;GO:0006282;GO:0034693;GO:0043484;GO:0045893;GO:0071005;GO:0071006;GO:0071011;GO:0071016;GO:0071018;GO:1903241;GO:1990935	mRNA splicing, via spliceosome [GO:0000398, IDA]; RNA binding [GO:0003723, IDA]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; spliceosomal complex [GO:0005681, IPI]; U2-type spliceosomal complex [GO:0005684, IDA]; U2-type spliceosomal complex [GO:0005684, IPI]; U12-type spliceosomal complex [GO:0005689, IDA]; U12-type spliceosomal complex [GO:0005689, IPI]; U11/U12 snRNP [GO:0034693, IPI]; U2-type precatalytic spliceosome [GO:0071005, IDA]; U2-type catalytic step 1 spliceosome [GO:0071006, IPI]; precatalytic spliceosome [GO:0071011, IPI]; U12-type precatalytic spliceosome [GO:0071016, IPI]; U12-type catalytic step 2 spliceosome [GO:0071018, IPI]; splicing factor binding [GO:1990935, IDA]	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome a
Q9H299	SH3BGRL3	93	other characterized small protein	Evidence at protein level	5.0	2002-11-01	0	0	SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1)	13	12	6	2	4	0	0	CP	0	1	1	GO:0005634;GO:0005829;GO:0007010;GO:0032587;GO:0070062	nucleus [GO:0005634, EXP]; cytosol [GO:0005829, IDA]; cytoskeleton organization [GO:0007010, IMP]; ruffle membrane [GO:0032587, IMP]; extracellular exosome [GO:0070062, HDA]	Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization (PubMed:34380438). {ECO:0000269|PubMed:34380438, ECO:0000305|PubMed:15907482}.
O00631	SLN	31	other characterized small protein	Evidence at protein level	5.0	1997-11-01	0	1	Sarcolipin	29	23	5	0	4	14	0	CP	1	1	1	GO:0004857;GO:0005789;GO:0006816;GO:0016020;GO:0016529;GO:0030234;GO:0033017;GO:0043242;GO:0051117;GO:0051924;GO:0070296;GO:0090281;GO:0120162;GO:1901077;GO:1901881;GO:1901894;GO:1901895;GO:1902081	sarcoplasmic reticulum [GO:0016529, IDA]; sarcoplasmic reticulum membrane [GO:0033017, EXP]; regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901894, IDA]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895, IDA]	Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:11781085, PubMed:9575189). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Modulates calcium re-uptake during muscle relaxat
Q0VAQ4	SMAGP	97	other characterized small protein	Evidence at protein level	5.0	2008-04-08	0	1	Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein)	42	6	4	0	2	0	0	C	0	0	1	GO:0005886;GO:0030054;GO:0030659	plasma membrane [GO:0005886, EXP]; plasma membrane [GO:0005886, IDA]; cell junction [GO:0030054, IDA]; cytoplasmic vesicle membrane [GO:0030659, EXP]	May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation. {ECO:0000269|PubMed:15986429}.
Q9NRQ5	SMCO4	59	other characterized small protein	Evidence at protein level	5.0	2005-11-08	0	1	Single-pass membrane and coiled-coil domain-containing protein 4 (Protein FN5)	60	1	0	0	1	0	0		0	0	1	GO:0016020		
Q9UHP9	SMPX	88	other characterized small protein	Evidence at protein level	4.0	2000-12-01	0	0	Small muscular protein (Stretch-responsive skeletal muscle protein)	10	10	0	3	6	1	0		0	1	1	GO:0005634;GO:0005737;GO:0005927;GO:0006941;GO:0031430;GO:0043034;GO:0043292		Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. {ECO:0000250}.
O75971	SNAPC5	98	other characterized small protein	Evidence at protein level	5.0	2000-05-30	0	0	snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit)	68	25	6	0	4	15	0	CFP	1	1	1	GO:0000995;GO:0005634;GO:0005654;GO:0006366;GO:0006384;GO:0016251;GO:0019185;GO:0042795;GO:0042796	RNA polymerase III general transcription initiation factor activity [GO:0000995, IDA]; nucleoplasm [GO:0005654, IDA]; RNA polymerase II general transcription initiation factor activity [GO:0016251, IDA]; snRNA-activating protein complex [GO:0019185, IPI]; snRNA transcription by RNA polymerase II [GO:0042795, IDA]; snRNA transcription by RNA polymerase III [GO:0042796, IDA]	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
O75324	SNN	88	other characterized small protein	Evidence at protein level	5.0	1998-12-15	0	1	Stannin (AG8_1)	9	9	4	1	3	1	0	CF	1	1	1	GO:0005737;GO:0005741;GO:0009636;GO:0016020;GO:0046872	cytoplasm [GO:0005737, IDA]; mitochondrial outer membrane [GO:0005741, EXP]; membrane [GO:0016020, IDA]; metal ion binding [GO:0046872, IDA]	Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288). {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:27015288}.
P62304	SNRPE	92	other characterized small protein	Evidence at protein level	5.0	1988-08-01	0	0	Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE)	186	148	46	8	5	89	0	CP	1	1	1	GO:0000244;GO:0000245;GO:0000387;GO:0000388;GO:0000398;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005682;GO:0005683;GO:0005684;GO:0005685;GO:0005686;GO:0005687;GO:0005689;GO:0005690;GO:0005697;GO:0005829;GO:0030532;GO:0034693;GO:0034709;GO:0034715;GO:0034719;GO:0036261;GO:0046540;GO:0048025;GO:0071001;GO:0071002;GO:0071005;GO:0071006;GO:0071007;GO:0071009;GO:0071011;GO:0071013;GO:0071014;GO:0071016;GO:0071018;GO:0071020;GO:0071045;GO:1903241	spliceosomal snRNP assembly [GO:0000387, IDA]; mRNA splicing, via spliceosome [GO:0000398, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; spliceosomal complex [GO:0005681, IPI]; U7 snRNP [GO:0005683, IDA]; U2-type spliceosomal complex [GO:0005684, IDA]; U1 snRNP [GO:0005685, IDA]; U1 snRNP [GO:0005685, IPI]; U4 snRNP [GO:0005687, IDA]; U12-type spliceosomal complex [GO:0005689, IDA]; U12-type spliceosomal complex [GO:0005689, IPI]; telomerase holoenzyme complex [GO:0005697, IDA]; cytosol [GO:0005829, IDA]; U11/U12 snRNP [GO:0034693, IPI]; methylosome [GO:0034709, IDA]; pICln-Sm protein complex [GO:0034715, IDA]; SMN-Sm protein complex [GO:0034719, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; U2-type precatalytic spliceosome [GO:0071005, IDA]; U2-type catalytic step 1 spliceosome [GO:0071006, IPI]; U2-type catalytic step 2 spliceosome [GO:0071007, IDA]; U2-type catalytic step 2 spliceosome [GO:0071007, IPI]; precatalytic spliceosome [GO:0071011, IPI]; catalytic step 2 spliceosome [GO:0071013, IDA]; post-mRNA release spliceosomal complex [GO:0071014, IPI]; U12-type precatalytic spliceosome [GO:0071016, IPI]; U12-type catalytic step 2 spliceosome [GO:0071018, IPI]; post-spliceosomal complex [GO:0071020, IPI]	Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23246290, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed
P62306	SNRPF	86	other characterized small protein	Evidence at protein level	5.0	2004-07-05	0	0	Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)	217	148	48	5	9	86	0	CFP	1	1	1	GO:0000244;GO:0000245;GO:0000387;GO:0000388;GO:0000398;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005682;GO:0005683;GO:0005684;GO:0005685;GO:0005686;GO:0005687;GO:0005689;GO:0005690;GO:0005829;GO:0008380;GO:0022618;GO:0030532;GO:0034693;GO:0034709;GO:0034715;GO:0034719;GO:0036261;GO:0046540;GO:0048025;GO:0071001;GO:0071002;GO:0071005;GO:0071006;GO:0071007;GO:0071009;GO:0071011;GO:0071013;GO:0071014;GO:0071016;GO:0071018;GO:0071020;GO:0071045;GO:1903241	spliceosomal snRNP assembly [GO:0000387, IDA]; mRNA splicing, via spliceosome [GO:0000398, IDA]; RNA binding [GO:0003723, IMP]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; spliceosomal complex [GO:0005681, IDA]; spliceosomal complex [GO:0005681, IPI]; U7 snRNP [GO:0005683, IDA]; U2-type spliceosomal complex [GO:0005684, IDA]; U1 snRNP [GO:0005685, IDA]; U1 snRNP [GO:0005685, IPI]; U4 snRNP [GO:0005687, IDA]; U12-type spliceosomal complex [GO:0005689, IDA]; U12-type spliceosomal complex [GO:0005689, IPI]; cytosol [GO:0005829, IDA]; RNA splicing [GO:0008380, IMP]; small nuclear ribonucleoprotein complex [GO:0030532, IDA]; U11/U12 snRNP [GO:0034693, IPI]; methylosome [GO:0034709, IDA]; pICln-Sm protein complex [GO:0034715, IDA]; SMN-Sm protein complex [GO:0034719, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; U2-type precatalytic spliceosome [GO:0071005, IDA]; U2-type catalytic step 1 spliceosome [GO:0071006, IPI]; U2-type catalytic step 2 spliceosome [GO:0071007, IDA]; U2-type catalytic step 2 spliceosome [GO:0071007, IPI]; precatalytic spliceosome [GO:0071011, IPI]; catalytic step 2 spliceosome [GO:0071013, IDA]; post-mRNA release spliceosomal complex [GO:0071014, IPI]; U12-type precatalytic spliceosome [GO:0071016, IPI]; U12-type catalytic step 2 spliceosome [GO:0071018, IPI]; post-spliceosomal complex [GO:0071020, IPI]	Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed
P62308	SNRPG	76	other characterized small protein	Evidence at protein level	5.0	2004-07-05	0	0	Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)	181	153	44	13	6	90	0	CFP	1	1	1	GO:0000244;GO:0000245;GO:0000387;GO:0000388;GO:0000398;GO:0003723;GO:0005634;GO:0005654;GO:0005681;GO:0005682;GO:0005683;GO:0005684;GO:0005685;GO:0005686;GO:0005687;GO:0005689;GO:0005690;GO:0005829;GO:0008380;GO:0030532;GO:0034693;GO:0034709;GO:0034719;GO:0036261;GO:0043186;GO:0046540;GO:0048025;GO:0071001;GO:0071002;GO:0071004;GO:0071005;GO:0071006;GO:0071007;GO:0071009;GO:0071011;GO:0071013;GO:0071014;GO:0071016;GO:0071018;GO:0071020;GO:0071045;GO:0097526;GO:1903241	spliceosomal snRNP assembly [GO:0000387, IDA]; mRNA splicing, via spliceosome [GO:0000398, IDA]; RNA binding [GO:0003723, HDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; spliceosomal complex [GO:0005681, IPI]; U7 snRNP [GO:0005683, IDA]; U2-type spliceosomal complex [GO:0005684, IDA]; U1 snRNP [GO:0005685, IDA]; U1 snRNP [GO:0005685, IPI]; U4 snRNP [GO:0005687, IDA]; U12-type spliceosomal complex [GO:0005689, IDA]; U12-type spliceosomal complex [GO:0005689, IPI]; cytosol [GO:0005829, IDA]; U11/U12 snRNP [GO:0034693, IPI]; methylosome [GO:0034709, IDA]; SMN-Sm protein complex [GO:0034719, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IDA]; U4/U6 x U5 tri-snRNP complex [GO:0046540, IPI]; U2-type precatalytic spliceosome [GO:0071005, IDA]; U2-type catalytic step 1 spliceosome [GO:0071006, IPI]; U2-type catalytic step 2 spliceosome [GO:0071007, IDA]; U2-type catalytic step 2 spliceosome [GO:0071007, IPI]; precatalytic spliceosome [GO:0071011, IPI]; catalytic step 2 spliceosome [GO:0071013, IDA]; post-mRNA release spliceosomal complex [GO:0071014, IPI]; U12-type precatalytic spliceosome [GO:0071016, IPI]; U12-type catalytic step 2 spliceosome [GO:0071018, IPI]; post-spliceosomal complex [GO:0071020, IPI]	Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed
Q9NS26	SPANXA1; SPANXA2	97	other characterized small protein	Evidence at protein level	4.0	2005-02-01	0	0	Sperm protein associated with the nucleus on the X chromosome A (Cancer/testis antigen 11.1) (CT11.1) (Nuclear-associated protein SPAN-Xa) (SPAN-X) (SPANX-A) (SPANX family member A)	9	6	1	0	2	3	0	C	0	1	1	GO:0005634;GO:0005737;GO:0007283	nucleus [GO:0005634, HDA]	
Q9NY87	SPANXC	97	other characterized small protein	Evidence at protein level	3.0	2005-02-01	0	0	Sperm protein associated with the nucleus on the X chromosome C (Cancer/testis antigen 11.3) (CT11.3) (Cancer/testis-associated protein CTp11) (Nuclear-associated protein SPAN-Xc) (SPANX-C) (SPANX family member C)	6	4	1	0	2	1	0	C	0	0	1	GO:0005634;GO:0005737	nucleus [GO:0005634, HDA]	
Q9BXN6	SPANXD	97	other characterized small protein	Evidence at protein level	3.0	2005-02-01	0	0	Sperm protein associated with the nucleus on the X chromosome D (Cancer/testis antigen 11.4) (CT11.4) (Nuclear-associated protein SPAN-Xd) (SPANX-D) (SPANX family member D)	6	3	1	0	2	0	0	C	0	0	1	GO:0005634;GO:0005737	nucleus [GO:0005634, HDA]	
Q5VSR9	SPANXN1	72	other characterized small protein	Inferred from homology	2.0	2007-05-01	0	0	Sperm protein associated with the nucleus on the X chromosome N1 (Nuclear-associated protein SPAN-Xn1) (SPANX-N1) (SPANX family member N1)	0	0	0	0	0	0	0		0	0	0			
Q5MJ08	SPANXN4	99	other characterized small protein	Evidence at protein level	2.0	2007-05-01	0	0	Sperm protein associated with the nucleus on the X chromosome N4 (Nuclear-associated protein SPAN-Xn4) (SPANX-N4) (SPANX family member N4)	0	0	0	0	0	0	0		0	0	0			
Q5MJ07	SPANXN5	72	other characterized small protein	Inferred from homology	2.0	2007-05-01	0	0	Sperm protein associated with the nucleus on the X chromosome N5 (Nuclear-associated protein SPAN-Xn5) (SPANX-N5) (SPANX family member N5)	0	0	0	0	0	0	0		0	0	0			
Q537H7	SPATA45	98	other characterized small protein	Evidence at protein level	2.0	2007-05-01	0	0	Spermatogenesis-associated protein 45	0	0	0	0	0	0	0		0	0	0			
Q969W0	SPTSSA	71	other characterized small protein	Evidence at protein level	5.0	2005-07-05	0	1	Serine palmitoyltransferase small subunit A (Small subunit of serine palmitoyltransferase A) (ssSPTa)	36	28	20	3	2	3	0	CFP	1	1	1	GO:0004758;GO:0005783;GO:0005789;GO:0006665;GO:0006686;GO:0006688;GO:0008104;GO:0017059;GO:0030148;GO:0046512;GO:0046513;GO:0098554	serine C-palmitoyltransferase activity [GO:0004758, IDA]; endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum membrane [GO:0005789, EXP]; sphingomyelin biosynthetic process [GO:0006686, IDA]; glycosphingolipid biosynthetic process [GO:0006688, IDA]; intracellular protein localization [GO:0008104, IDA]; serine palmitoyltransferase complex [GO:0017059, IDA]; serine palmitoyltransferase complex [GO:0017059, IPI]; sphingosine biosynthetic process [GO:0046512, IDA]; ceramide biosynthetic process [GO:0046513, IDA]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554, IDA]	Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851). The SPT complex is composed of
Q8NFR3	SPTSSB	76	other characterized small protein	Evidence at protein level	5.0	2006-06-13	0	1	Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)	19	18	4	4	4	6	0	CFP	1	1	1	GO:0004758;GO:0005789;GO:0006665;GO:0007029;GO:0017059;GO:0030148;GO:0046512;GO:0046513	serine C-palmitoyltransferase activity [GO:0004758, IDA]; serine palmitoyltransferase complex [GO:0017059, IDA]; serine palmitoyltransferase complex [GO:0017059, IPI]; sphingosine biosynthetic process [GO:0046512, IDA]	Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851). The SPT complex is composed of
P49458	SRP9	86	other characterized small protein	Evidence at protein level	5.0	1996-02-01	0	0	Signal recognition particle 9 kDa protein (SRP9)	27	15	0	2	6	7	0		1	1	1	GO:0003723;GO:0005047;GO:0005737;GO:0005785;GO:0005786;GO:0005829;GO:0006614;GO:0006617;GO:0008312;GO:0045900;GO:0048500		Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elong
Q9UHA2	SS18L2	77	other characterized small protein	Evidence at protein level	2.0	2002-10-25	0	0	SS18-like protein 2 (SYT homolog 2)	7	0	0	0	0	0	1		0	0	0			
Q9HBF5	ST20	79	other characterized small protein	Evidence at protein level	3.0	2008-06-10	0	0	Suppressor of tumorigenicity 20 protein (Human cervical cancer suppressor gene 1 protein) (HCCS-1)	3	3	3	0	0	0	0	FP	1	1	0	GO:0071494;GO:0097190;GO:0140608	cellular response to UV-C [GO:0071494, IMP]; apoptotic signaling pathway [GO:0097190, IDA]; cysteine-type endopeptidase activator activity [GO:0140608, IDA]	May act as a tumor suppressor. Promotes apoptosis of cancer cells. {ECO:0000269|PubMed:11857354}.
E0CX11	STMP1	47	other characterized small protein	Evidence at protein level	5.0	2011-10-19	0	1	Short transmembrane mitochondrial protein 1	16	15	4	1	3	7	0	CP	0	1	1	GO:0005739;GO:0005741;GO:0005743;GO:0005758;GO:0032731;GO:0033617;GO:0034551;GO:0097250;GO:0098803;GO:1900227	mitochondrion [GO:0005739, HTP]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial respiratory chain complex IV assembly [GO:0033617, IMP]; mitochondrial respirasome assembly [GO:0097250, IMP]	Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35450818). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35450818). Also required for t
P61956	SUMO2	95	other characterized small protein	Evidence at protein level	5.0	2004-06-07	0	0	Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)	87	55	13	4	3	35	0	CFP	1	1	1	GO:0003723;GO:0005634;GO:0005654;GO:0016604;GO:0016605;GO:0016925;GO:0031386;GO:0031625;GO:0032436;GO:0044389	RNA binding [GO:0003723, HDA]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; nuclear body [GO:0016604, IDA]; PML body [GO:0016605, IDA]; protein sumoylation [GO:0016925, IDA]; ubiquitin protein ligase binding [GO:0031625, IPI]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436, IDA]	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase su
Q6EEV6	SUMO4	95	other characterized small protein	Evidence at protein level	5.0	2005-11-08	0	0	Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)	21	21	15	4	2	0	0	CP	1	1	1	GO:0005634;GO:0005654;GO:0016604;GO:0016925;GO:0031386;GO:0034599;GO:0043122;GO:0043388;GO:0043392;GO:0044389;GO:0045892;GO:0106068;GO:1900180	nucleoplasm [GO:0005654, IDA]; nuclear body [GO:0016604, IDA]; protein sumoylation [GO:0016925, IDA]; cellular response to oxidative stress [GO:0034599, IDA]; regulation of canonical NF-kappaB signal transduction [GO:0043122, IDA]; positive regulation of DNA binding [GO:0043388, IDA]; negative regulation of DNA binding [GO:0043392, IDA]; negative regulation of DNA-templated transcription [GO:0045892, IDA]; SUMO ligase complex [GO:0106068, IDA]; regulation of protein localization to nucleus [GO:1900180, IDA]	Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and str
Q8NHG7	SVIP	77	other characterized small protein	Evidence at protein level	5.0	2005-08-30	0	0	Small VCP/p97-interacting protein	29	27	10	5	5	7	0	CFP	1	1	1	GO:0000139;GO:0005765;GO:0005789;GO:0005886;GO:0010508;GO:0016020;GO:0030667;GO:0030868;GO:0031333;GO:0051117;GO:0070062;GO:0070821;GO:1903061;GO:1904153;GO:1904240;GO:1904293	lysosomal membrane [GO:0005765, EXP]; endoplasmic reticulum membrane [GO:0005789, IDA]; positive regulation of autophagy [GO:0010508, IMP]; membrane [GO:0016020, IDA]; negative regulation of protein-containing complex assembly [GO:0031333, IMP]; ATPase binding [GO:0051117, IPI]; extracellular exosome [GO:0070062, HDA]; positive regulation of protein lipidation [GO:1903061, IMP]; obsolete negative regulation of retrograde protein transport, ER to cytosol [GO:1904153, IMP]; negative regulation of ERAD pathway [GO:1904293, IMP]	Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates (PubMed:17872946). Involved in the regulation of adrenal cort
A1L190	SYCE3	88	other characterized small protein	Evidence at protein level	5.0	2009-03-24	0	0	Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG-2)	38	27	0	3	11	13	0		0	1	1	GO:0000794;GO:0000795;GO:0000801;GO:0005634;GO:0005694;GO:0007129;GO:0007130;GO:0007131;GO:0007283;GO:0035825		Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:36635604). Required for the assembly of the central element of the synaptonemal complex during meiosis, via remodeling of SYCP1 lattice structures 
Q9BRU2	TCEAL7	100	other characterized small protein	Evidence at protein level	3.0	2006-05-30	0	0	Transcription elongation factor A protein-like 7 (TCEA-like protein 7) (Transcription elongation factor S-II protein-like 7)	4	4	3	0	1	0	0	CP	0	1	1	GO:0005634;GO:0005654;GO:0045892	nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; negative regulation of DNA-templated transcription [GO:0045892, IDA]	Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telom
Q3Y452	TDRG1	100	other characterized small protein	Evidence at protein level	2.0	2012-10-03	0	0	Testis development-related protein 1	1	1	0	0	1	0	0		0	0	1	GO:0005737		
P62072	TIMM10	90	other characterized small protein	Evidence at protein level	5.0	2004-06-21	0	0	Mitochondrial import inner membrane translocase subunit Tim10	39	32	15	3	6	8	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0005744;GO:0005758;GO:0008270;GO:0032977;GO:0042719;GO:0042721;GO:0042803;GO:0045039;GO:0051087;GO:0090150;GO:0140309	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial intermembrane space [GO:0005758, IDA]; mitochondrial intermembrane space chaperone complex [GO:0042719, IDA]; mitochondrial intermembrane space chaperone complex [GO:0042719, IPI]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721, IPI]; protein homodimerization activity [GO:0042803, IPI]; protein insertion into mitochondrial inner membrane [GO:0045039, IDA]; protein-folding chaperone binding [GO:0051087, IPI]; unfolded protein holdase activity [GO:0140309, IDA]	Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of 
Q9Y5L4	TIMM13	95	other characterized small protein	Evidence at protein level	5.0	2001-01-11	0	0	Mitochondrial import inner membrane translocase subunit Tim13	18	15	6	2	1	6	0	CP	1	1	1	GO:0005739;GO:0005743;GO:0005758;GO:0008270;GO:0042719;GO:0045039	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial intermembrane space chaperone complex [GO:0042719, IPI]; protein insertion into mitochondrial inner membrane [GO:0045039, IMP]	Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of th
O60220	TIMM8A	97	other characterized small protein	Evidence at protein level	5.0	1999-07-15	0	0	Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)	31	15	8	0	3	4	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0005758;GO:0007399;GO:0008270;GO:0042719;GO:0042802;GO:0045039;GO:0070585	mitochondrion [GO:0005739, HDA]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial intermembrane space [GO:0005758, IDA]; mitochondrial intermembrane space chaperone complex [GO:0042719, IPI]; identical protein binding [GO:0042802, IPI]; protein insertion into mitochondrial inner membrane [GO:0045039, IMP]	Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of th
Q9Y5J9	TIMM8B	83	other characterized small protein	Evidence at protein level	4.0	2001-01-11	0	0	Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2)	11	11	2	0	1	8	0	C	1	1	1	GO:0005576;GO:0005739;GO:0005743;GO:0005758;GO:0008270;GO:0042719;GO:0045039;GO:0140318	extracellular region [GO:0005576, HDA]; mitochondrion [GO:0005739, HTP]	Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM compl
Q9Y5J7	TIMM9	89	other characterized small protein	Evidence at protein level	5.0	2001-01-11	0	0	Mitochondrial import inner membrane translocase subunit Tim9	35	31	15	3	5	8	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0005758;GO:0008270;GO:0042719;GO:0042721;GO:0042803;GO:0045039;GO:0051087;GO:0140309;GO:0140318	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; mitochondrial intermembrane space [GO:0005758, IDA]; mitochondrial intermembrane space chaperone complex [GO:0042719, IDA]; mitochondrial intermembrane space chaperone complex [GO:0042719, IPI]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721, IPI]; protein homodimerization activity [GO:0042803, IPI]; protein insertion into mitochondrial inner membrane [GO:0045039, IDA]; protein-folding chaperone binding [GO:0051087, IPI]; unfolded protein holdase activity [GO:0140309, IDA]	Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of 
Q9Y2S6	TMA7	64	other characterized small protein	Evidence at protein level	3.0	2006-05-16	0	0	Translation machinery-associated protein 7 (Coiled-coil domain-containing protein 72)	0	0	0	0	0	0	0		0	0	0			
Q9Y6G1	TMEM14A	99	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	1	Transmembrane protein 14A	33	8	4	1	3	0	0	CP	0	1	1	GO:0005789;GO:0016020;GO:0031966;GO:0043066;GO:1901029	endoplasmic reticulum membrane [GO:0005789, IDA]; mitochondrial membrane [GO:0031966, IDA]; negative regulation of apoptotic process [GO:0043066, IMP]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029, IMP]	Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. {ECO:0000269|PubMed:21723035}.
A6NJY4	TMEM238L	79	other characterized small protein	Evidence at protein level	3.0	2008-07-22	0	1	Transmembrane protein 238-like (FOXA1-regulated conserved small protein) (FORCP)	5	3	2	0	1	0	0	CP	0	1	1	GO:0005789;GO:0070059	endoplasmic reticulum membrane [GO:0005789, IDA]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059, IMP]	May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. {ECO:0000269|PubMed:33112233}.
P61165	TMEM258	79	other characterized small protein	Evidence at protein level	5.0	2004-05-10	0	1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 (Oligosaccharyl transferase subunit TMEM258) (Transmembrane protein 258)	40	33	16	3	4	10	0	CP	1	1	1	GO:0005737;GO:0005783;GO:0005789;GO:0006487;GO:0008250;GO:0009306;GO:0016020;GO:0034976;GO:0062062;GO:0160226;GO:0160227	cytoplasm [GO:0005737, IDA]; endoplasmic reticulum [GO:0005783, IDA]; protein N-linked glycosylation [GO:0006487, IDA]; protein N-linked glycosylation [GO:0006487, IMP]; oligosaccharyltransferase complex [GO:0008250, IDA]; oligosaccharyltransferase complex [GO:0008250, IPI]; protein secretion [GO:0009306, IDA]; membrane [GO:0016020, IDA]; response to endoplasmic reticulum stress [GO:0034976, IMP]; oligosaccharyltransferase complex A [GO:0160226, IDA]; oligosaccharyltransferase complex B [GO:0160227, IDA]	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the firs
P63313	TMSB10	44	other characterized small protein	Evidence at protein level	4.0	2004-10-11	0	0	Thymosin beta-10	10	6	0	3	3	0	0		1	1	1	GO:0003785;GO:0005856;GO:0007015;GO:0030334;GO:0140311		Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.
P0CG34	TMSB15A	45	other characterized small protein	Evidence at protein level	3.0	2010-07-13	0	0	Thymosin beta-15A (NB thymosin beta) (Thymosin-like protein 8)	7	7	0	4	3	0	0		1	1	1	GO:0003785;GO:0005856;GO:0007015;GO:0030334;GO:0031941;GO:0140311		Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250|UniProtKB:P62328}.
P0CG35	TMSB15B	45	other characterized small protein	Evidence at protein level	3.0	2010-07-13	0	0	Thymosin beta-15B	8	8	1	4	3	0	0	P	1	1	1	GO:0003785;GO:0005856;GO:0007015;GO:0030334;GO:0030335;GO:0031941;GO:0140311	positive regulation of cell migration [GO:0030335, IMP]	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration (PubMed:19296525). {ECO:0000250|UniProtKB:P62328, ECO:0000269|PubMed:19296525}.
P62328	TMSB4X	44	other characterized small protein	Evidence at protein level	5.0	1986-07-21	0	0	Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)]	47	34	22	4	5	3	0	CFP	1	1	1	GO:0003723;GO:0003785;GO:0003788;GO:0005576;GO:0005634;GO:0005737;GO:0005829;GO:0005856;GO:0007015;GO:0019899;GO:0030334;GO:0030837;GO:0031093;GO:0033209;GO:0043124;GO:0043536;GO:0050728;GO:0140311;GO:1902037;GO:1902807;GO:2001028;GO:2001171	RNA binding [GO:0003723, HDA]; actin monomer binding [GO:0003785, IDA]; actin monomer sequestering activity [GO:0003788, IDA]; extracellular region [GO:0005576, HDA]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; enzyme binding [GO:0019899, IPI]; negative regulation of actin filament polymerization [GO:0030837, IDA]; tumor necrosis factor-mediated signaling pathway [GO:0033209, IMP]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124, IMP]; positive regulation of blood vessel endothelial cell migration [GO:0043536, IDA]; positive regulation of blood vessel endothelial cell migration [GO:0043536, IGI]; negative regulation of inflammatory response [GO:0050728, IMP]; protein sequestering activity [GO:0140311, IMP]; negative regulation of hematopoietic stem cell differentiation [GO:1902037, IDA]; positive regulation of endothelial cell chemotaxis [GO:2001028, IDA]; positive regulation of ATP biosynthetic process [GO:2001171, IDA]	Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). {ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398}.; [Hemoregulato
O14604	TMSB4Y	44	other characterized small protein	Evidence at protein level	3.0	1999-07-15	0	0	Thymosin beta-4, Y-chromosomal	9	8	0	4	3	1	0		1	1	1	GO:0003785;GO:0005829;GO:0005856;GO:0007015;GO:0008064;GO:0030334;GO:0140311		Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.
P09430	TNP1	55	other characterized small protein	Evidence at protein level	5.0	1989-07-01	0	0	Spermatid nuclear transition protein 1 (STP-1) (TP-1)	34	31	11	5	7	8	0	CFP	1	1	1	GO:0000012;GO:0000786;GO:0001673;GO:0003677;GO:0005634;GO:0005694;GO:0006337;GO:0006338;GO:0007283;GO:0007286;GO:0007289;GO:0007290;GO:0010954;GO:0019953;GO:0030317;GO:0031507;GO:0035041;GO:0035092;GO:0045892	single strand break repair [GO:0000012, IDA]; nucleosome [GO:0000786, IDA]; DNA binding [GO:0003677, IMP]; nucleosome disassembly [GO:0006337, IMP]; chromatin remodeling [GO:0006338, IDA]; spermatid development [GO:0007286, IDA]; spermatid nucleus elongation [GO:0007290, IMP]; sexual reproduction [GO:0019953, IMP]; flagellated sperm motility [GO:0030317, IMP]; heterochromatin formation [GO:0031507, IEP]; negative regulation of DNA-templated transcription [GO:0045892, IDA]	Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. {ECO:0000250|UniProtKB:P10856}.
Q8N4H5	TOMM5	51	other characterized small protein	Evidence at protein level	5.0	2006-04-04	0	1	Mitochondrial import receptor subunit TOM5 homolog	11	11	3	1	2	5	0	C	0	1	1	GO:0005739;GO:0005741;GO:0005742;GO:0045040;GO:0070585;GO:0140596	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial outer membrane translocase complex [GO:0005742, IDA]	Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondri
Q96B49	TOMM6	74	other characterized small protein	Evidence at protein level	5.0	2007-09-11	0	1	Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog)	20	9	2	1	2	4	0	C	0	1	1	GO:0005739;GO:0005741;GO:0005742;GO:0045040;GO:0140596	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]	Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondri
Q9P0U1	TOMM7	55	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	1	Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog)	21	18	6	2	3	7	0	CP	1	1	1	GO:0005739;GO:0005741;GO:0005742;GO:0008320;GO:0030150;GO:0031647;GO:0045040;GO:0140596;GO:1903749;GO:1905091	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial outer membrane translocase complex [GO:0005742, IDA]; regulation of protein stability [GO:0031647, IMP]; obsolete positive regulation of protein localization to mitochondrion [GO:1903749, IMP]; positive regulation of type 2 mitophagy [GO:1905091, IMP]	Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondri
O43715	TRIAP1	76	other characterized small protein	Evidence at protein level	5.0	2000-12-01	0	0	TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV)	35	27	18	4	2	3	0	CFP	1	1	1	GO:0002039;GO:0005739;GO:0005758;GO:0015914;GO:0030330;GO:0031571;GO:0032991;GO:0034644;GO:0043066;GO:0045944;GO:0090201;GO:0097035;GO:1902166;GO:1990050;GO:2001140	p53 binding [GO:0002039, IPI]; mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial intermembrane space [GO:0005758, IDA]; phospholipid transport [GO:0015914, IDA]; DNA damage response, signal transduction by p53 class mediator [GO:0030330, IDA]; mitotic G1 DNA damage checkpoint signaling [GO:0031571, IDA]; protein-containing complex [GO:0032991, IDA]; cellular response to UV [GO:0034644, IDA]; negative regulation of apoptotic process [GO:0043066, IMP]; positive regulation of transcription by RNA polymerase II [GO:0045944, IDA]; negative regulation of release of cytochrome c from mitochondria [GO:0090201, IMP]; regulation of membrane lipid distribution [GO:0097035, IMP]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166, IMP]; phosphatidic acid transfer activity [GO:1990050, IDA]; positive regulation of phospholipid transport [GO:2001140, IDA]	Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the 
Q629K1	TRIQK	86	other characterized small protein	Evidence at protein level	2.0	2008-06-10	0	1	Triple QxxK/R motif-containing protein (Triple repetitive-sequence of QXXK/R protein homolog)	2	2	0	0	2	0	0		0	0	1	GO:0005789		May play a role in cell growth and maintenance of cell morphology. {ECO:0000250}.
H0UI37	TSTD3	97	other characterized small protein	Inferred from homology	2.0	2012-10-03	0	0	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 (Rhodanese domain-containing protein 3)	0	0	0	0	0	0	0		0	0	0			
Q9BZL1	UBL5	73	other characterized small protein	Evidence at protein level	5.0	2004-09-13	0	0	Ubiquitin-like protein 5	58	16	6	5	3	2	0	CP	1	1	1	GO:0000398;GO:0005634;GO:0005654;GO:0005737;GO:0015030;GO:0031386;GO:0036211;GO:1903749	nucleus [GO:0005634, EXP]; cytoplasm [GO:0005737, EXP]; cytoplasm [GO:0005737, IDA]; obsolete positive regulation of protein localization to mitochondrion [GO:1903749, HMP]	Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins (PubMed:25092792). Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair
P61960	UFM1	85	other characterized small protein	Evidence at protein level	5.0	2004-06-07	0	0	Ubiquitin-fold modifier 1	49	32	17	4	9	2	0	CP	0	1	1	GO:0005634;GO:0005737;GO:0005783;GO:0007420;GO:0033146;GO:0034976;GO:0042308;GO:0043066;GO:0061709;GO:0071569;GO:1990592	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; brain development [GO:0007420, IMP]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146, IDA]; response to endoplasmic reticulum stress [GO:0034976, IDA]; response to endoplasmic reticulum stress [GO:0034976, IMP]; negative regulation of protein import into nucleus [GO:0042308, IMP]; reticulophagy [GO:0061709, IMP]; protein ufmylation [GO:0071569, IDA]; protein ufmylation [GO:0071569, IMP]; protein K69-linked ufmylation [GO:1990592, IDA]	Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:27653677, PubMed:29868776, PubMed:30626644, PubMed:38377992, PubMed:38383785). The so-called ufmy
Q15836	VAMP3	100	other characterized small protein	Evidence at protein level	5.0	1997-11-01	0	1	Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)	120	54	9	5	6	34	0	CP	1	1	1	GO:0001921;GO:0005484;GO:0005829;GO:0005886;GO:0006887;GO:0006906;GO:0016020;GO:0016192;GO:0030133;GO:0030136;GO:0030669;GO:0030670;GO:0031201;GO:0031901;GO:0032588;GO:0034446;GO:0035493;GO:0042147;GO:0043231;GO:0045202;GO:0055037;GO:0055038;GO:0061025;GO:0065003;GO:1903531	cytosol [GO:0005829, IDA]; clathrin-coated vesicle [GO:0030136, IDA]; SNARE complex [GO:0031201, IDA]; early endosome membrane [GO:0031901, EXP]; retrograde transport, endosome to Golgi [GO:0042147, IDA]; intracellular membrane-bounded organelle [GO:0043231, IDA]; recycling endosome [GO:0055037, IDA]; recycling endosome membrane [GO:0055038, EXP]; negative regulation of secretion by cell [GO:1903531, IDA]	SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.
Q9BV40	VAMP8	100	other characterized small protein	Evidence at protein level	5.0	2004-11-23	0	1	Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)	109	93	37	7	11	38	0	CFP	1	1	1	GO:0000421;GO:0001772;GO:0005484;GO:0005737;GO:0005764;GO:0005765;GO:0005768;GO:0005769;GO:0005829;GO:0005886;GO:0006906;GO:0009267;GO:0016020;GO:0016192;GO:0016236;GO:0016240;GO:0019869;GO:0030667;GO:0030669;GO:0030670;GO:0031201;GO:0031901;GO:0031902;GO:0031982;GO:0035493;GO:0035577;GO:0035579;GO:0042589;GO:0043316;GO:0043933;GO:0046718;GO:0048471;GO:0055037;GO:0055038;GO:0070062;GO:0070254;GO:0070821;GO:0097352;GO:0098594;GO:0140522;GO:1903076;GO:1903531;GO:1903595	immunological synapse [GO:0001772, IDA]; helical-bundle zippering fusogenic activity [GO:0005484, IDA]; cytoplasm [GO:0005737, IDA]; lysosomal membrane [GO:0005765, IDA]; cytosol [GO:0005829, IDA]; plasma membrane [GO:0005886, IDA]; vesicle fusion [GO:0006906, IDA]; membrane [GO:0016020, IDA]; autophagosome membrane docking [GO:0016240, IDA]; chloride channel inhibitor activity [GO:0019869, IDA]; secretory granule membrane [GO:0030667, IDA]; SNARE complex [GO:0031201, IDA]; SNARE complex [GO:0031201, IPI]; early endosome membrane [GO:0031901, EXP]; late endosome membrane [GO:0031902, EXP]; late endosome membrane [GO:0031902, IDA]; vesicle [GO:0031982, IDA]; azurophil granule membrane [GO:0035577, IDA]; cytotoxic T cell degranulation [GO:0043316, IMP]; symbiont entry into host cell [GO:0046718, IMP]; perinuclear region of cytoplasm [GO:0048471, IDA]; recycling endosome [GO:0055037, IDA]; extracellular exosome [GO:0070062, HDA]; mucus secretion [GO:0070254, IMP]; autophagosome maturation [GO:0097352, IMP]; mucin granule [GO:0098594, IDA]; fusogenic activity [GO:0140522, IDA]; regulation of protein localization to plasma membrane [GO:1903076, IDA]; negative regulation of secretion by cell [GO:1903531, IDA]; positive regulation of histamine secretion by mast cell [GO:1903595, IMP]	SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives 
Q9HD64	XAGE1A; XAGE1B	81	other characterized small protein	Evidence at protein level	4.0	2001-09-26	0	0	X antigen family member 1 (XAGE-1) (Cancer/testis antigen 12.1) (CT12.1) (G antigen family D member 2)	7	0	0	0	0	0	1		0	0	0			
Q9Y5V0	ZNF706	76	other characterized small protein	Evidence at protein level	3.0	2005-10-25	0	0	Transcriptional regulator ZNF706 (Zinc finger protein 706)	12	12	0	0	6	6	0		0	1	1	GO:0005634;GO:0005737;GO:0045892;GO:1902455		Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal (By similarity). Acts by repressing expression of KLF4 (By similarity). Required for Wnt signaling activation (PubMed:41298547). {ECO:0000250|UniProtKB:Q9D115, ECO:0000269|PubMed:41298547}.
O75394	MRPL33	65	ribosomal protein	Evidence at protein level	4.0	2006-05-30	0	0	Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33)	28	28	6	1	5	16	0	C	1	1	1	GO:0003735;GO:0005737;GO:0005739;GO:0005743;GO:0005762;GO:0005840;GO:0006412;GO:0032543	mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial large ribosomal subunit [GO:0005762, IDA]	
Q9BQ48	MRPL34	92	ribosomal protein	Evidence at protein level	3.0	2002-01-31	0	0	Large ribosomal subunit protein bL34m (39S ribosomal protein L34, mitochondrial) (L34mt) (MRP-L34)	31	31	7	1	4	19	0	C	1	1	1	GO:0003735;GO:0005739;GO:0005743;GO:0005761;GO:0005762;GO:0005840;GO:0006412;GO:0032543	mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial large ribosomal subunit [GO:0005762, IDA]	
P82921	MRPS21	87	ribosomal protein	Evidence at protein level	4.0	2001-05-04	0	0	Small ribosomal subunit protein bS21m (28S ribosomal protein S21, mitochondrial) (MRP-S21) (S21mt)	27	27	5	0	4	18	0	CF	1	1	1	GO:0003723;GO:0003735;GO:0005739;GO:0005743;GO:0005763;GO:0005840;GO:0006412;GO:0032543	RNA binding [GO:0003723, HDA]; mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial small ribosomal subunit [GO:0005763, IDA]	
P61927	RPL37	97	ribosomal protein	Evidence at protein level	5.0	1986-07-21	0	0	Large ribosomal subunit protein eL37 (60S ribosomal protein L37) (G1.16)	63	63	10	3	10	40	0	CFP	1	1	1	GO:0000448;GO:0002181;GO:0003723;GO:0003735;GO:0005737;GO:0005829;GO:0005840;GO:0006412;GO:0006941;GO:0007283;GO:0022625;GO:0022626;GO:0045202;GO:0097371;GO:1901740;GO:1901798;GO:1990948	structural constituent of ribosome [GO:0003735, IDA]; cytoplasm [GO:0005737, EXP]; cytosolic large ribosomal subunit [GO:0022625, HDA]; cytosolic large ribosomal subunit [GO:0022625, IDA]; cytosolic large ribosomal subunit [GO:0022625, IPI]; cytosolic ribosome [GO:0022626, IDA]; MDM2/MDM4 family protein binding [GO:0097371, IPI]; positive regulation of signal transduction by p53 class mediator [GO:1901798, IDA]; ubiquitin ligase inhibitor activity [GO:1990948, IDA]	Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P61513	RPL37A	92	ribosomal protein	Evidence at protein level	5.0	2004-05-24	0	0	Large ribosomal subunit protein eL43 (60S ribosomal protein L37a)	62	53	11	1	5	36	0	CF	1	1	1	GO:0002181;GO:0003723;GO:0003735;GO:0005634;GO:0005737;GO:0005829;GO:0005840;GO:0005925;GO:0006412;GO:0006941;GO:0007283;GO:0022625;GO:0022626;GO:0070062;GO:1901740	RNA binding [GO:0003723, HDA]; structural constituent of ribosome [GO:0003735, IDA]; nucleus [GO:0005634, HDA]; cytoplasm [GO:0005737, EXP]; focal adhesion [GO:0005925, HDA]; cytosolic large ribosomal subunit [GO:0022625, HDA]; cytosolic large ribosomal subunit [GO:0022625, IDA]; cytosolic large ribosomal subunit [GO:0022625, IPI]; cytosolic ribosome [GO:0022626, IDA]; extracellular exosome [GO:0070062, HDA]	Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
A6NKH3	RPL37AP8	93	ribosomal protein	Uncertain	2.0	2008-04-08	0	0	Putative ribosomal protein eL43-like (Putative 60S ribosomal protein L37a-like protein) (Ribosomal protein L37a pseudogene 8)	5	5	0	1	4	0	0		1	1	1	GO:0003735;GO:0005840;GO:0006412;GO:0022625		
P63173	RPL38	70	ribosomal protein	Evidence at protein level	5.0	2004-09-27	0	0	Large ribosomal subunit protein eL38 (60S ribosomal protein L38)	68	67	14	3	10	40	0	CFP	1	1	1	GO:0002181;GO:0003723;GO:0003735;GO:0005737;GO:0005783;GO:0005829;GO:0005840;GO:0005925;GO:0006412;GO:0006941;GO:0007283;GO:0014069;GO:0022625;GO:0022626;GO:0033291;GO:0045202;GO:1901740	cytoplasmic translation [GO:0002181, IDA]; structural constituent of ribosome [GO:0003735, IDA]; cytoplasm [GO:0005737, EXP]; endoplasmic reticulum [GO:0005783, IDA]; cytosol [GO:0005829, IDA]; focal adhesion [GO:0005925, HDA]; postsynaptic density [GO:0014069, EXP]; postsynaptic density [GO:0014069, IDA]; cytosolic large ribosomal subunit [GO:0022625, HDA]; cytosolic large ribosomal subunit [GO:0022625, IDA]; cytosolic large ribosomal subunit [GO:0022625, IPI]; cytosolic ribosome [GO:0022626, IDA]	Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P62891	RPL39	51	ribosomal protein	Evidence at protein level	5.0	1986-07-21	0	0	Large ribosomal subunit protein eL39 (60S ribosomal protein L39)	60	60	14	3	4	39	0	CFP	1	1	1	GO:0002181;GO:0002227;GO:0003723;GO:0003735;GO:0005576;GO:0005737;GO:0005829;GO:0005840;GO:0006412;GO:0006941;GO:0019731;GO:0022625;GO:0022626;GO:0050830;GO:0061844;GO:1901740	cytoplasmic translation [GO:0002181, IDA]; innate immune response in mucosa [GO:0002227, IDA]; structural constituent of ribosome [GO:0003735, IDA]; extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, EXP]; antibacterial humoral response [GO:0019731, IDA]; cytosolic large ribosomal subunit [GO:0022625, HDA]; cytosolic large ribosomal subunit [GO:0022625, IDA]; cytosolic large ribosomal subunit [GO:0022625, IPI]; cytosolic ribosome [GO:0022626, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:8764829}.
Q96EH5	RPL39L	51	ribosomal protein	Evidence at protein level	3.0	2003-03-28	0	0	Ribosomal protein eL39-like 2 (60S ribosomal protein L39-2) (60S ribosomal protein L39-like) (Large ribosomal subunit protein eL39-like)	18	16	2	4	4	6	0	CP	1	1	1	GO:0002181;GO:0003735;GO:0005737;GO:0005840;GO:0006412;GO:0007283;GO:0022625	spermatogenesis [GO:0007283, IEP]; cytosolic large ribosomal subunit [GO:0022625, IPI]	Male germ cell-specific component of the ribosome, which is required for the formation of sperm and male fertility. Replaces the RPL39 paralog in the ribosome of male germ cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The male germ ce
Q59GN2	RPL39P5	51	ribosomal protein	Uncertain	2.0	2008-09-02	0	0	Putative ribosomal protein eL39-like 5 (60S ribosomal protein L39 pseudogene 5) (Putative 60S ribosomal protein L39-like 5)	6	6	0	3	3	0	0		1	1	1	GO:0002181;GO:0003735;GO:0005840;GO:0006412;GO:0022625		
P62945	RPL41	25	ribosomal protein	Evidence at protein level	5.0	2004-08-31	0	0	Small ribosomal subunit protein eS32 (60S ribosomal protein L41) (HG12) (Large ribosomal subunit protein eL41)	52	51	8	0	4	39	0	CFP	1	1	1	GO:0002181;GO:0003723;GO:0003730;GO:0003735;GO:0005737;GO:0005783;GO:0005829;GO:0005840;GO:0006412;GO:0006941;GO:0007283;GO:0022625;GO:0048027;GO:1901740	cytoplasmic translation [GO:0002181, IDA]; mRNA 3'-UTR binding [GO:0003730, IDA]; cytoplasm [GO:0005737, EXP]; endoplasmic reticulum [GO:0005783, IDA]; cytosolic large ribosomal subunit [GO:0022625, HDA]; cytosolic large ribosomal subunit [GO:0022625, IDA]; cytosolic large ribosomal subunit [GO:0022625, IPI]; mRNA 5'-UTR binding [GO:0048027, IDA]	Component of the small ribosomal subunit (Probable) (Ref.8). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha 
P63220	RPS21	83	ribosomal protein	Evidence at protein level	5.0	2004-09-27	0	0	Small ribosomal subunit protein eS21 (40S ribosomal protein S21)	72	65	10	5	10	40	0	CFP	1	1	1	GO:0000447;GO:0000461;GO:0002181;GO:0003723;GO:0003735;GO:0005654;GO:0005737;GO:0005791;GO:0005829;GO:0005840;GO:0006412;GO:0015935;GO:0022626;GO:0022627;GO:0045202	cytoplasmic translation [GO:0002181, IDA]; RNA binding [GO:0003723, HDA]; structural constituent of ribosome [GO:0003735, HDA]; structural constituent of ribosome [GO:0003735, IDA]; cytosol [GO:0005829, IDA]; small ribosomal subunit [GO:0015935, HDA]; cytosolic ribosome [GO:0022626, IDA]; cytosolic small ribosomal subunit [GO:0022627, HDA]; cytosolic small ribosomal subunit [GO:0022627, IDA]	Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:
P42677	RPS27	84	ribosomal protein	Evidence at protein level	5.0	1995-11-01	0	0	Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1)	79	74	12	4	5	53	0	CFP	1	1	1	GO:0002181;GO:0003677;GO:0003723;GO:0003735;GO:0005634;GO:0005654;GO:0005730;GO:0005737;GO:0005829;GO:0005840;GO:0006364;GO:0006412;GO:0008270;GO:0014069;GO:0022626;GO:0022627;GO:0032040;GO:0042274	RNA binding [GO:0003723, HDA]; structural constituent of ribosome [GO:0003735, IDA]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, EXP]; rRNA processing [GO:0006364, IMP]; postsynaptic density [GO:0014069, EXP]; postsynaptic density [GO:0014069, IDA]; cytosolic ribosome [GO:0022626, IDA]; cytosolic small ribosomal subunit [GO:0022627, HDA]; cytosolic small ribosomal subunit [GO:0022627, IDA]; small-subunit processome [GO:0032040, IDA]; ribosomal small subunit biogenesis [GO:0042274, IDA]	Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small 
Q71UM5	RPS27L	84	ribosomal protein	Evidence at protein level	5.0	2004-08-16	0	0	Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like)	19	18	11	4	3	0	0	CFP	1	1	1	GO:0003723;GO:0003735;GO:0005634;GO:0005730;GO:0005783;GO:0005829;GO:0005840;GO:0006364;GO:0006412;GO:0008494;GO:0022627;GO:0030330;GO:0031571;GO:0042771;GO:0045727	RNA binding [GO:0003723, HDA]; nucleus [GO:0005634, IDA]; nucleolus [GO:0005730, IDA]; endoplasmic reticulum [GO:0005783, IDA]; cytosol [GO:0005829, IDA]; translation activator activity [GO:0008494, IDA]; DNA damage response, signal transduction by p53 class mediator [GO:0030330, IDA]; mitotic G1 DNA damage checkpoint signaling [GO:0031571, IMP]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771, IDA]; positive regulation of translation [GO:0045727, IDA]	
P62857	RPS28	69	ribosomal protein	Evidence at protein level	5.0	2004-08-16	0	0	Small ribosomal subunit protein eS28 (40S ribosomal protein S28)	78	71	17	4	11	39	0	CFP	1	1	1	GO:0000028;GO:0002181;GO:0003723;GO:0003735;GO:0005654;GO:0005730;GO:0005737;GO:0005791;GO:0005829;GO:0005840;GO:0006364;GO:0006412;GO:0015935;GO:0022626;GO:0022627;GO:0030490;GO:0032040;GO:0042254;GO:0042274;GO:0045202;GO:0070062;GO:0098556	cytoplasmic translation [GO:0002181, IDA]; RNA binding [GO:0003723, HDA]; structural constituent of ribosome [GO:0003735, HDA]; structural constituent of ribosome [GO:0003735, IDA]; structural constituent of ribosome [GO:0003735, IMP]; ribosome [GO:0005840, IDA]; rRNA processing [GO:0006364, IMP]; small ribosomal subunit [GO:0015935, HDA]; cytosolic small ribosomal subunit [GO:0022627, HDA]; cytosolic small ribosomal subunit [GO:0022627, IDA]; small-subunit processome [GO:0032040, IDA]; ribosome biogenesis [GO:0042254, IMP]; ribosomal small subunit biogenesis [GO:0042274, IDA]; ribosomal small subunit biogenesis [GO:0042274, IMP]; extracellular exosome [GO:0070062, HDA]	Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first
P62273	RPS29	56	ribosomal protein	Evidence at protein level	5.0	2004-07-05	0	0	Small ribosomal subunit protein uS14 (40S ribosomal protein S29)	65	65	14	4	8	39	0	CFP	1	1	1	GO:0002181;GO:0003735;GO:0005654;GO:0005737;GO:0005783;GO:0005791;GO:0005829;GO:0005840;GO:0005925;GO:0006412;GO:0008270;GO:0015935;GO:0022626;GO:0022627;GO:0070062;GO:0098556	cytoplasmic translation [GO:0002181, IDA]; structural constituent of ribosome [GO:0003735, HDA]; structural constituent of ribosome [GO:0003735, IDA]; endoplasmic reticulum [GO:0005783, IDA]; cytosol [GO:0005829, IDA]; ribosome [GO:0005840, IDA]; focal adhesion [GO:0005925, HDA]; zinc ion binding [GO:0008270, IDA]; small ribosomal subunit [GO:0015935, HDA]; cytosolic small ribosomal subunit [GO:0022627, HDA]; cytosolic small ribosomal subunit [GO:0022627, IDA]; extracellular exosome [GO:0070062, HDA]	Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:
A0A7L8Y648	AQP5-AS1	51	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2023-11-08	0	0	Micropeptide inhibiting actin cytoskeleton	4	2	2	0	0	0	0	P	0	1	0	GO:0007015;GO:0042058	actin filament organization [GO:0007015, IMP]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058, IMP]	Reduces filamentous actin fibers by interacting with aquaporin AQP2 which leads to inhibition of the expression of SEPTIN4 and integrin ITGB4 (PubMed:32176498). Also inhibits the activation of the EREG/EGFR signaling pathway through interaction with AQP2 (PubMed:36117171). {ECO:0000269|PubMed:321764
L0R819	ASDURF	96	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2017-11-22	0	0	ASNSD1 upstream open reading frame protein (ASNSD1 small/short open reading frame-encoded polypeptide) (ASNSD1-SEP)	4	4	2	0	1	1	0	C	0	1	1	GO:0005737;GO:0050821;GO:1990062	cytoplasm [GO:0005737, EXP]; RPAP3/R2TP/prefoldin-like complex [GO:1990062, IPI]	
A0A1B0GUI7	BRD3OS	84	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-06-20	0	0	Uncharacterized protein BRD3OS (BRD3 opposite strand protein) (Long intergenic non-protein coding RNA 94) (Non-protein coding RNA 94)	0	0	0	0	0	0	0		0	0	0			
C0HM83		58	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2023-11-08	0	0	Protein SHMOOSE (Small human mitochondrial ORF over serine tRNA)	6	4	2	0	2	0	0	C	0	0	1	GO:0005634;GO:0005739	nucleus [GO:0005634, IDA]; mitochondrion [GO:0005739, IDA]	Increases neural cell metabolic activity and mitochondrial oxygen consumption rate. {ECO:0000269|PubMed:36127429}.
Q8N6V4	C10orf53	93	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2005-07-05	0	0	UPF0728 protein C10orf53	0	0	0	0	0	0	0		0	0	0			
Q8TCD1	C18orf32	76	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2008-02-26	0	0	UPF0729 protein C18orf32 (Putative NF-kappa-B-activating protein 200)	9	6	4	0	2	0	0	CP	0	1	1	GO:0005783;GO:0005811;GO:0043123	endoplasmic reticulum [GO:0005783, EXP]; endoplasmic reticulum [GO:0005783, IDA]; lipid droplet [GO:0005811, IDA]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, HMP]	May activate the NF-kappa-B signaling pathway. {ECO:0000269|PubMed:12761501}.
Q9UNZ5	C19orf53	99	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2001-11-02	0	0	Leydig cell tumor 10 kDa protein homolog	0	0	0	0	0	0	0		0	0	0			May have a potential role in hypercalcemia of malignancy. {ECO:0000250}.
A1L168	C20orf202	99	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2008-05-20	0	0	Uncharacterized protein C20orf202	8	0	0	0	0	0	1		0	0	0			
Q8WU43	C2orf15	91	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2005-07-05	0	0	Uncharacterized protein C2orf15	6	1	1	0	0	0	0	F	1	0	0	GO:0003723	RNA binding [GO:0003723, HDA]	
Q9NRJ1	C8orf17	99	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2008-04-29	0	0	Protein MOST-1	8	6	2	0	2	2	0	C	0	1	1	GO:0005634;GO:0005737;GO:0005789;GO:0008284;GO:0043066	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]	May be involved in cell survival, proliferation and progression of cancer cells. {ECO:0000269|PubMed:12665628}.
H3BU77	CCDC179	68	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2013-03-06	0	0	Coiled-coil domain-containing protein 179	2	0	0	0	0	0	1		0	0	0			
A8MTT3	CEBPZOS	80	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2015-03-04	0	1	Protein CEBPZOS (CEBPZ antisense RNA 1) (CEBPZ opposite strand)	3	3	2	0	1	0	0	C	0	0	1	GO:0005739;GO:0031966	mitochondrion [GO:0005739, HTP]; mitochondrial membrane [GO:0031966, EXP]	
A0A1B0GV96	CHD9NB	52	sORF-class microprotein, protein-level evidence	Evidence at protein level	1.0	2023-02-22	0	0	CHD9 neighbor protein	0	0	0	0	0	0	0		0	0	0			
Q96GX8	CLMB	76	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2006-12-12	0	0	Calcimembrin (Microprotein for thermogenesis 1)	11	4	3	0	1	0	0	CP	0	1	1	GO:0005886;GO:0016020;GO:1990845	plasma membrane [GO:0005886, IDA]; membrane [GO:0016020, IDA]; adaptive thermogenesis [GO:1990845, IDA]	Associates with and recruits the catalytic subunit of the calcineurin complex (PPP3CA/Calcineurin A) to the plasma membrane, where it functions as a dynamic scaffold and regulator of PPP3CA activity thereby modulating calcineurin signaling (PubMed:41224739). In brown adipocytes, regulates thermogene
P0DPQ6	DDIT3	34	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2018-10-10	0	0	DDIT3 upstream open reading frame protein (Alternative DDIT3 protein) (AltDDIT3)	5	4	2	0	2	0	0	C	0	0	1	GO:0005634;GO:0005737	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]	[Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. {ECO:0000250|UniProtKB:A0A2R8VHR8}.
P0DI80	ERLN	62	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2011-09-21	0	1	Endoregulin (ELN) (Small integral membrane protein 6)	2	2	0	0	1	1	0		0	0	1	GO:0005789		Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+). {ECO:0000250|UniProtKB:Q3U0I6}.
A0A1B0GVR7	FAM240C	95	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2019-06-05	0	0	Protein FAM240C	0	0	0	0	0	0	0		0	0	0			
B0L3A2	FBXW7-AS1	85	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2021-06-02	0	1	Dual endothelin-1/VEGF signal peptide receptor (DEspR protein) (Dual endothelin-1/VEGFsp receptor) (FBXW7 antisense RNA 1)	9	8	7	0	1	0	0	CFP	1	1	1	GO:0004962;GO:0005886;GO:0038084;GO:0038085;GO:0086100	endothelin receptor activity [GO:0004962, IDA]; plasma membrane [GO:0005886, IDA]; vascular endothelial growth factor signaling pathway [GO:0038084, IDA]; vascular endothelial growth factor binding [GO:0038085, IDA]; endothelin receptor signaling pathway [GO:0086100, IDA]	Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A (PubMed:17446437, PubMed:24465725). Does not act as a receptor for angiotensin-2 (PubMed:17446437). Does not bind the VEGFA mature protein (By similarity). May play a role in angiogenesis with a signi
C0HLZ6	HOXB-AS3	53	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2022-02-23	0	0	HOXB-AS3 peptide	5	3	3	0	0	0	0	P	0	1	0	GO:0043484;GO:0050821;GO:2000632	regulation of RNA splicing [GO:0043484, IMP]; protein stabilization [GO:0050821, IMP]; negative regulation of pre-miRNA processing [GO:2000632, IDA]	Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif (PubMed:28985503). This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production o
P0DUH7	HRURF	34	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2021-09-29	0	0	Protein HRURF (HR upstream open reading frame protein)	0	0	0	0	0	0	0		0	0	0			May function as an inhibitory translational control element that can negatively regulate protein translation of HR gene. {ECO:0000269|PubMed:19122663}.
Q15053	KIAA0040	99	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	1998-07-15	0	1	Uncharacterized protein KIAA0040	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A455ZAR2	LINC-PINT	87	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2022-02-23	0	0	Transcriptional regulator PINT87aa	6	3	2	0	1	0	0	CP	0	1	1	GO:0000122;GO:0005634	negative regulation of transcription by RNA polymerase II [GO:0000122, IMP]; nucleus [GO:0005634, IDA]	Enhances the binding of the PAF1 complex to target gene promoters and plays a role in negative regulation of transcription (PubMed:30367041). May function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA polymerase II-induced mRNA elongation (PubMed:30367041).
Q99440	LINC01587	93	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2000-12-01	0	0	Uncharacterized protein encoded by LINC01587 (Protein AC1)	1	1	0	0	0	1	0		0	1	0	GO:0007399		
P0DW81	MARCHF6-DT	44	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2022-10-12	0	0	Poly-ADP-ribosylation-amplifying and CtIP-maintaining micropeptide (PAR-amplifying and CtIP-maintaining micropeptide)	11	9	7	0	2	0	0	CFP	1	1	1	GO:0005694;GO:0005730;GO:0010835;GO:0031397;GO:0045739;GO:0072572;GO:0090734	chromosome [GO:0005694, EXP]; nucleolus [GO:0005730, IDA]; regulation of protein ADP-ribosylation [GO:0010835, IDA]; negative regulation of protein ubiquitination [GO:0031397, IDA]; positive regulation of DNA repair [GO:0045739, IDA]; poly-ADP-D-ribose binding [GO:0072572, IDA]; site of DNA damage [GO:0090734, IDA]	Micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination and degradation of RBBP8/CtIP, and by promoting the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:35219381). Prevents KLHL15-mediated ubiquitination of RBBP8/CtIP by competitively blocking t
Q5TGZ0	MICOS10	78	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2006-10-03	0	1	MICOS complex subunit MIC10 (Mitochondrial inner membrane organizing system protein 1)	25	18	9	1	3	5	0	CP	0	1	1	GO:0001401;GO:0005739;GO:0005743;GO:0007007;GO:0042407;GO:0044284;GO:0061617;GO:0140275	SAM complex [GO:0001401, HDA]; mitochondrion [GO:0005739, HDA]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, EXP]; cristae formation [GO:0042407, IMP]; MICOS complex [GO:0061617, HDA]; MIB complex [GO:0140275, HDA]	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:32567732, E
L0R8F8	MIEF1	70	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2017-03-15	0	0	Mitochondrial ribosome and complex I assembly factor AltMIEF1 (Alternative MIEF1 protein) (AltMIEF1) (MIEF1 microprotein) (MIEF1-MP) (alternative transcript upstream of MiD51) (AltMiD51)	19	14	13	0	1	0	0	CFP	1	1	1	GO:0000266;GO:0005739;GO:0005759;GO:0032981;GO:0070131;GO:0140978;GO:1902775	mitochondrial fission [GO:0000266, IMP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial matrix [GO:0005759, EXP]; mitochondrial matrix [GO:0005759, IDA]; mitochondrial respiratory chain complex I assembly [GO:0032981, IMP]; positive regulation of mitochondrial translation [GO:0070131, IDA]; mitochondrial large ribosomal subunit binding [GO:0140978, IDA]; mitochondrial large ribosomal subunit assembly [GO:1902775, IDA]; mitochondrial large ribosomal subunit assembly [GO:1902775, IMP]	Assembly factor involved in the biogenesis of the mitochondrial-specific ribosomes (mitoribosomes) (PubMed:28892042, PubMed:30215512, PubMed:31666358). Specifically associates with intermediates of the mitochondrial ribosome large subunit (mt-LSU) and is required for proper ribosome assembly, possib
C0HMA1	MIR155HG	17	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2024-01-24	0	0	HSPA8-interacting micropeptide miPEP155 (P155)	6	6	4	0	2	0	0	CFP	1	1	1	GO:0002605;GO:0005634;GO:0005737;GO:0030544	negative regulation of dendritic cell antigen processing and presentation [GO:0002605, IDA]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; Hsp70 protein binding [GO:0030544, IPI]	Negatively regulates MHC class II antigen presentation in dendritic cells by interacting with the molecular chaperone HSPA8 and impairing its role in lysosomal antigen transport (PubMed:32671205). Does not regulate the levels or activity of the MIR155HG microRNA from which miPEP155 is derived (PubMe
C0HLV8	MLDHR	31	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2021-06-02	0	0	PTEN upstream open reading frame MP31 (Micropeptide 31) (Mitochondrial lactate dehydrogenase regulator)	6	4	3	0	1	0	0	CFP	1	1	1	GO:0005739;GO:0090324;GO:0160193	mitochondrion [GO:0005739, IDA]; negative regulation of oxidative phosphorylation [GO:0090324, IMP]; L-lactate dehydrogenase inhibitor activity [GO:0160193, IDA]	Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+) (PubMed:33406399). Also inhibits cellular lactate utilization (PubMed:33406399). {ECO:0000269|PubMed:33406399}.
A0A0U1RRL7	MMP24OS	71	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-06-20	0	0	Protein MMP24OS (MMP24 opposite strand)	0	0	0	0	0	0	0		0	0	0			
P0DMT0	MRLN	46	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2015-04-01	0	1	Myoregulin	8	8	0	0	4	4	0		1	1	1	GO:0004857;GO:0005789;GO:0033017;GO:1902081		Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of
Q8NCU8	MTLN	56	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2008-05-20	0	1	Mitoregulin (Micropeptide in mitochondria) (Micropeptide regulator of beta-oxidation) (Small integral membrane protein 37) (lncRNA-encoded micropeptide)	24	22	4	2	8	8	0	CP	0	1	1	GO:0005739;GO:0005743;GO:0006629;GO:0006635;GO:0010918;GO:0032000;GO:0045333;GO:0051146;GO:0070328;GO:0097250	mitochondrion [GO:0005739, IDA]; fatty acid beta-oxidation [GO:0006635, IMP]; triglyceride homeostasis [GO:0070328, IMP]; mitochondrial respirasome assembly [GO:0097250, IDA]	Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (PubMed:29949756). Increases mitochondrial respiration rate (PubMed:29949756). Increased mitochondrial respiratory a
A0A1B0GTQ4	MYMX	84	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2017-09-27	0	1	Protein myomixer (Microprotein inducer of fusion) (Protein minion) (hMINION)	24	24	2	6	10	6	0	P	0	1	1	GO:0000139;GO:0005789;GO:0005886;GO:0007520;GO:0014905;GO:0043403;GO:0060538;GO:0140253	myoblast fusion [GO:0007520, IGI]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905, IMP]	Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28569745, PubMed:35642635). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (By similarity). Acts by generating membrane stresses via
A0A1B0GUC4	MYOCOS	80	sORF-class microprotein, protein-level evidence	Evidence at protein level	1.0	2017-11-22	0	0	Myocilin opposite strand protein	0	0	0	0	0	0	0		0	0	0			
A0A0U1RRE5	NBDY	68	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2017-03-15	0	0	Negative regulator of P-body association (P-body dissociating protein) (Protein NoBody)	7	4	3	0	1	0	0	CP	0	1	1	GO:0000932;GO:0000956;GO:0010607	P-body [GO:0000932, IDA]; nuclear-transcribed mRNA catabolic process [GO:0000956, IDA]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607, IDA]	Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process. {ECO:0000269|PubMed:27918561}.
A0A087WWA1	P3R3URF	95	sORF-class microprotein, protein-level evidence	Evidence at protein level	1.0	2019-02-13	0	0	PIK3R3 upstream open reading frame protein	1	1	0	1	0	0	0		0	1	0	GO:0019221		
A0A0B4J2F0	PIGBOS1	54	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2015-09-16	0	1	Protein PIGBOS1 (PIGB opposite strand protein 1)	7	5	3	0	2	0	0	CP	0	1	1	GO:0005739;GO:0005741;GO:1900101	mitochondrion [GO:0005739, HTP]; mitochondrial outer membrane [GO:0005741, IDA]; regulation of endoplasmic reticulum unfolded protein response [GO:1900101, IMP]	Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen. {ECO:0000269|PubMed:31653868}.
C0HM02	PRKCH	26	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2022-05-25	0	0	PRKCH upstream open reading frame 2 (uORF2) (Protein uPEP2)	10	10	10	0	0	0	0	FP	1	1	0	GO:0017148;GO:0030291;GO:0032056;GO:0034198;GO:0045182;GO:0120283	negative regulation of translation [GO:0017148, IDA]; negative regulation of translation [GO:0017148, IMP]; protein serine/threonine kinase inhibitor activity [GO:0030291, IDA]; positive regulation of translation in response to stress [GO:0032056, IDA]; cellular response to amino acid starvation [GO:0034198, IDA]; translation regulator activity [GO:0045182, IDA]; protein serine/threonine kinase binding [GO:0120283, IPI]	Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF (PubMed:19797084, PubMed:34593629). Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression duri
A0A286YEY9	SCYGR1	88	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-10-10	0	0	Small cysteine and glycine repeat-containing protein 1 (Keratin-associated protein 28-1)	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
A0A286YF60	SCYGR3	100	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-10-10	0	0	Small cysteine and glycine repeat-containing protein 3 (Keratin-associated protein 28-3)	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
A0A286YF46	SCYGR5	85	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-10-10	0	0	Small cysteine and glycine repeat-containing protein 5 (Keratin-associated protein 28-5)	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
A0A286YF01	SCYGR7	96	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-10-10	0	0	Small cysteine and glycine repeat-containing protein 7 (Keratin-associated protein 28-7)	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
P0DSO2	SCYGR9	92	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2020-08-12	0	0	Small cysteine and glycine repeat-containing protein 9 (Keratin-associated protein 28-1 pseudogene)	0	0	0	0	0	0	0		0	0	0			In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cys
B2RUZ4	SMIM1	78	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2008-12-16	0	1	Small integral membrane protein 1 (Vel blood group antigen)	64	10	6	3	1	0	0	CF	1	1	1	GO:0005886;GO:0009986;GO:0042803;GO:0048823	plasma membrane [GO:0005886, IDA]; plasma membrane [GO:0005886, IMP]; cell surface [GO:0009986, IDA]; cell surface [GO:0009986, IMP]; protein homodimerization activity [GO:0042803, IDA]	Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}.
Q96HG1	SMIM10	83	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2008-07-22	0	1	Small integral membrane protein 10	1	1	0	0	1	0	0		0	0	1	GO:0016020		
P0DMW3	SMIM10L1	68	sORF-class microprotein, protein-level evidence	Evidence at protein level	1.0	2015-06-24	0	0	Small integral membrane protein 10-like protein 1	1	1	1	0	0	0	0	C	0	0	1	GO:0005739	mitochondrion [GO:0005739, HTP]	
P58511	SMIM11	58	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2002-01-23	0	1	Small integral membrane protein 11	4	1	0	0	1	0	0		0	0	1	GO:0016020		
Q96EX1	SMIM12	92	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2007-09-11	0	1	Small integral membrane protein 12	5	2	1	0	1	0	0	C	0	0	1	GO:0005739;GO:0016020	mitochondrion [GO:0005739, HTP]	
P0DJ93	SMIM13	91	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2011-12-14	0	1	Small integral membrane protein 13	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q96QK8	SMIM14	99	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2006-12-12	0	1	Small integral membrane protein 14	9	3	1	1	1	0	0	C	0	0	1	GO:0005783;GO:0005789	endoplasmic reticulum [GO:0005783, IDA]	
Q7Z3B0	SMIM15	74	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2008-03-18	0	1	Small integral membrane protein 15	1	1	0	0	1	0	0		0	0	1	GO:0016020		
P0DKX4	SMIM18	95	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2013-03-06	0	1	Small integral membrane protein 18	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q9BVW6	SMIM2	85	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2008-02-26	0	1	Small integral membrane protein 2	4	1	0	0	1	0	0		0	0	1	GO:0016020		
K7EJ46	SMIM22	83	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2013-11-13	0	1	Small integral membrane protein 22 (Cancer-associated small integral membrane open reading frame 1)	9	8	5	1	2	0	0	P	0	1	1	GO:0005770;GO:0016020;GO:0030335;GO:0032956;GO:0042127;GO:0051726;GO:0140042	positive regulation of cell migration [GO:0030335, IMP]; regulation of actin cytoskeleton organization [GO:0032956, IMP]; regulation of cell population proliferation [GO:0042127, IMP]; regulation of cell cycle [GO:0051726, IMP]; lipid droplet formation [GO:0140042, IMP]	May modulate lipid droplet formation throught interaction with SQLE. {ECO:0000269|PubMed:29765154}.
A0A096LP01	SMIM26	95	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2017-07-05	0	1	Small integral membrane protein 26	9	7	5	1	1	0	0	CF	1	0	1	GO:0005739;GO:0005741;GO:0019901;GO:0044325	mitochondrion [GO:0005739, IDA]; mitochondrial outer membrane [GO:0005741, EXP]; mitochondrial outer membrane [GO:0005741, IDA]; protein kinase binding [GO:0019901, IPI]; transmembrane transporter binding [GO:0044325, IPI]	May play a role in cell viability. {ECO:0000269|PubMed:34445188}.
Q9BZL3	SMIM3	60	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2004-07-19	0	1	Small integral membrane protein 3 (NGF-induced differentiation clone 67 protein) (Small membrane protein NID67)	60	2	1	0	1	0	0	F	1	0	1	GO:0016020;GO:0042802	identical protein binding [GO:0042802, IPI]	
A0A1B0GVT2	SMIM36	93	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2018-02-28	0	1	Small integral membrane protein 36	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q5STR5	SMIM40	79	sORF-class microprotein, protein-level evidence	Evidence at protein level	1.0	2019-02-13	0	1	Small integral membrane protein 40	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A2R8YCJ5	SMIM41	93	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2019-01-16	0	1	Small integral membrane protein 41	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q4W5P6	SMIM43	63	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2007-04-03	0	1	Small integral membrane protein 43 (Nodal enhanced mesendoderm micropeptide) (NEMEP)	10	10	2	0	5	3	0	F	1	1	1	GO:0005886;GO:0010828;GO:0044325;GO:0048382	transmembrane transporter binding [GO:0044325, IPI]	Required for mesendoderm differentiation (By similarity). Interacts with glucose transporters and promotes glucose uptake (PubMed:35810171). Probably augments the glucose uptake capacity of glucose transporter proteins to meet the energy needs of mesendoderm differentiation (By similarity). {ECO:000
Q71RC9	SMIM5	77	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2011-06-28	0	1	Small integral membrane protein 5	8	1	0	0	1	0	0		0	0	1	GO:0016020		
Q96KF7	SMIM8	97	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2005-07-19	0	1	Small integral membrane protein 8	2	2	1	0	1	0	0	C	0	0	1	GO:0005739;GO:0016020	mitochondrion [GO:0005739, HTP]	
Q9Y675	SNURF	71	sORF-class microprotein, protein-level evidence	Evidence at protein level	2.0	2008-02-26	0	0	SNRPN upstream reading frame protein	7	7	1	1	4	1	0	C	1	0	1	GO:0005634;GO:0016607;GO:0051117	nuclear speck [GO:0016607, IDA]	
A0A1B0GVQ0	SPAAR	90	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2017-02-15	0	1	Small regulatory polypeptide of amino acid response	11	11	5	0	5	1	0	CP	0	1	1	GO:0005765;GO:0031902;GO:0043416;GO:0046611;GO:0071230;GO:1904262	lysosomal membrane [GO:0005765, IDA]; late endosome membrane [GO:0031902, IDA]; lysosomal proton-transporting V-type ATPase complex [GO:0046611, IDA]; cellular response to amino acid stimulus [GO:0071230, IMP]; negative regulation of TORC1 signaling [GO:1904262, IMP]	[Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with am
P0DN84	STRIT1	35	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2016-03-16	0	1	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (SERCA regulator DWORF) (Dwarf open reading frame) (DWORF) (Small transmembrane regulator of ion transport 1)	53	8	0	0	2	6	0		1	1	1	GO:0008047;GO:0031449;GO:0033017;GO:1901894;GO:1902082		Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (By similarity). Also enhances the activity of the ATP2A2/SERCA2 ATPase (PubMed:33581112). Does not directly stimulate SERCA p
A0A1B0GU33	TEX53	70	sORF-class microprotein, protein-level evidence	Evidence at protein level	1.0	2018-01-31	0	0	Testis-expressed protein 53	0	0	0	0	0	0	0		0	0	0			
A0A2R8Y7D0	TINCR	87	sORF-class microprotein, protein-level evidence	Evidence at protein level	5.0	2021-02-10	0	0	Ubiquitin domain-containing protein TINCR (Placenta-specific protein 2) (Terminal differentiation-induced cornification regulator) (pTINCR microprotein)	9	9	3	0	3	3	0	CP	0	1	1	GO:0005634;GO:0005737;GO:0010838;GO:0070161;GO:0090303	nucleus [GO:0005634, EXP]; positive regulation of keratinocyte proliferation [GO:0010838, IMP]; anchoring junction [GO:0070161, EXP]	Promotes epithelial differentiation by enhancing the sumoylation and activation of CDC42 (PubMed:36369429). Promotes keratinocyte proliferation (PubMed:32012357). This contributes to the maintenance of skin homeostasis by enhancing wound healing after skin injury (By similarity). Acts as a tumor sup
A0A1B0GTB2	TUNAR	48	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2022-05-25	0	1	Protein TUNAR (pTUNAR) (Beta cell and neural cell-regulin) (BNLN) (TCL1 upstream neural differentiation-associated RNA)	11	11	5	0	1	5	0	CFP	1	1	1	GO:0005783;GO:0005789;GO:0032469;GO:0035774;GO:0045665;GO:0048812;GO:0051117;GO:0051480	endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum membrane [GO:0005789, EXP]; endoplasmic reticulum calcium ion homeostasis [GO:0032469, IDA]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774, IDA]; ATPase binding [GO:0051117, IPI]	In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (By similarity). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite 
A0A1B0GUW7	TZMP1	55	sORF-class microprotein, protein-level evidence	Evidence at protein level	3.0	2018-02-28	0	1	Transition zone microprotein 1 (Small integral membrane protein 27) (TOPORS antisense RNA 1)	3	3	2	0	1	0	0	CP	0	1	1	GO:0035869;GO:0060170;GO:0060271	ciliary transition zone [GO:0035869, IMP]; cilium assembly [GO:0060271, IMP]	Required for ciliogenesis. {ECO:0000269|PubMed:41270742}.
C0HLU2	ZNF689	46	sORF-class microprotein, protein-level evidence	Evidence at protein level	4.0	2021-09-29	0	0	Transcriptional regulator SEHBP (Short ORF-encoded histone-binding protein) (ZNF689 upstream open reading frame protein)	8	6	4	0	2	0	0	CFP	1	1	1	GO:0005634;GO:0005737;GO:0006357;GO:0042393	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; regulation of transcription by RNA polymerase II [GO:0006357, IDA]; histone binding [GO:0042393, IDA]	Plays a role in transcription regulation. {ECO:0000269|PubMed:33468658}.
A6NHS1		94	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-07-01	0	0	Putative uncharacterized protein ENSP00000347057	0	0	0	0	0	0	0		0	0	0			
A8MU10		97	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2008-09-02	0	0	Putative uncharacterized protein ENSP00000381562	0	0	0	0	0	0	0		0	0	0			
Q96IT6	ARHGAP5-AS1	56	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2005-07-19	0	0	Putative uncharacterized protein ARHGAP5-AS1 (ARHGAP5 antisense RNA 1) (ARHGAP5 antisense gene protein 1)	0	0	0	0	0	0	0		0	0	0			
Q5TC04	ATP1A1-AS1	95	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2011-03-08	0	0	Putative uncharacterized protein ATP1A1-AS1 (ATP1A1 antisense RNA 1) (ATP1A1 antisense gene protein 1) (ATP1A1 opposite strand protein)	0	0	0	0	0	0	0		0	0	0			
O60756	BCE1	84	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2000-05-30	0	0	Putative protein BCE-1	0	0	0	0	0	0	0		0	0	0			
C0HMG9		87	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2026-06-10	0	0	Pluripotency-associated Lin28b uORF-encoded microprotein (PLUM)	0	0	0	0	0	0	0		0	0	0			Acts as a cytoplasmic regulator of pluripotency and embryonic development (PubMed:41298451). Promotes the transition from the naive to the primed pluripotency state and safeguards the primed state (PubMed:41298451). Promotes L1TD1 condensate formation and prevents L1TD1 from binding and stabilizing 
Q9NPU4	C14orf132	83	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2004-05-24	0	1	Uncharacterized protein C14orf132	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A1B0GUV1	C17orf114	79	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2021-04-07	0	0	Uncharacterized protein C17orf114	0	0	0	0	0	0	0		0	0	0			
C9J3I9	C5orf58	81	sORF-class microprotein, putative (no protein-level evidence)	Evidence at protein level	1.0	2010-03-23	0	0	Putative uncharacterized protein C5orf58	0	0	0	0	0	0	0		0	0	0			
P0DO92	CDIPTOSP	83	sORF-class microprotein, putative (no protein-level evidence)	Evidence at protein level	2.0	2016-05-11	0	0	Putative protein T-ENOL (CDIP transferase opposite strand, pseudogene) (CDIPT antisense RNA 1)	0	0	0	0	0	0	0		0	0	0			
Q9UH64	CDKN2A-AS1	79	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2000-12-01	0	0	Putative uncharacterized protein CDKN2A-AS1 (CDKN2A antisense RNA 1) (CDKN2A antisense gene protein 1) (Protein CDKN2A-DT) (Susceptibility protein NSG-x)	0	0	0	0	0	0	0		0	0	0			
A0A1B0GU71	CFAP97D2	98	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2018-09-12	0	0	Uncharacterized protein CFAP97D2 (CFAP97 domain-containing protein 2)	0	0	0	0	0	0	0		0	0	0			
Q5SY13	COL5A1-AS1	56	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-06-10	0	0	Putative uncharacterized protein encoded by COL5A1-AS1 (COL5A1 antisense RNA 1) (COL5A1 antisense gene protein 1)	0	0	0	0	0	0	0		0	0	0			
A0A1B0GTU2	CTXND1	59	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2018-01-31	0	1	Cortexin domain-containing 1 protein	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A1B0GV90	CTXND2	55	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2018-01-31	0	1	Cortexin domain containing 2	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q9P1J3	DHRS4-AS1	65	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2003-10-03	0	0	Putative uncharacterized protein DHRS4-AS1 (DHRS4 antisense RNA 1) (DHRS4 antisense gene protein 1)	0	0	0	0	0	0	0		0	0	0			
Q9H4G8	DPH3P1	78	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2003-04-04	0	0	Putative DPH3 homolog B (CSL-type zinc finger-containing protein 1)	5	5	0	3	2	0	0		1	1	1	GO:0005506;GO:0005829;GO:0017183;GO:0046872		
Q17RA5	EPCIP-AS1	79	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2007-10-23	0	0	Putative uncharacterized protein EPCIP-AS1 (C21orf62 antisense RNA 1) (C21orf62 antisense gene protein 1) (EPCIP antisense RNA 1)	0	0	0	0	0	0	0		0	0	0			
Q3ZM63	ETDA	59	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2018-10-10	0	0	Embryonic testis differentiation protein homolog A	0	0	0	0	0	0	0		0	0	0			
P0DPP9	ETDB	59	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2018-10-10	0	0	Embryonic testis differentiation protein homolog B	0	0	0	0	0	0	0		0	0	0			
A0A1B0GVM5	ETDC	59	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2018-07-18	0	0	Embryonic testis differentiation protein homolog C	0	0	0	0	0	0	0		0	0	0			
A0A1B0GUQ0	FAM236A	79	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2017-05-10	0	0	Protein FAM236A	0	0	0	0	0	0	0		0	0	0			
A0A1B0GV22	FAM236B	79	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2017-05-10	0	0	Protein FAM236B	0	0	0	0	0	0	0		0	0	0			
P0DP71	FAM236C	79	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2017-07-05	0	0	Protein FAM236C	0	0	0	0	0	0	0		0	0	0			
A0A1B0GTK5	FAM236D	79	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2017-07-05	0	0	Protein FAM236D	0	0	0	0	0	0	0		0	0	0			
A0A1B0GVK7	FAM240A	83	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2017-09-27	0	0	Protein FAM240A	0	0	0	0	0	0	0		0	0	0			
A0A1B0GVZ2	FAM240B	78	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2017-09-27	0	0	Protein FAM240B	0	0	0	0	0	0	0		0	0	0			
P0C841	FAM66E	47	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-09-02	0	0	Putative protein FAM66E	0	0	0	0	0	0	0		0	0	0			
Q05BU3	FAM86JP	40	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-03-18	0	0	Putative protein FAM86JP	0	0	0	0	0	0	0		0	0	0			
Q8TAF5	FLVCR1-DT	88	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2007-09-11	0	0	Putative uncharacterized protein LQK1 (FLVCR1 antisense RNA 1) (FLVCR1 divergent transcript)	0	0	0	0	0	0	0		0	0	0			
Q96PS6	GAFA1	74	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2008-03-18	0	1	Putative uncharacterized protein GAFA-1 (Gene associated with FGF-2 activity protein 1)	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q8WZA8	GCRG224	35	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-03-18	0	0	Putative gastric cancer-related gene 224 protein (GCRG-224) (GCRG-p224)	0	0	0	0	0	0	0		0	0	0			
A0A804HLA8	GNG5B	68	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	3.0	2022-10-12	0	0	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B	8	8	0	3	4	1	0		1	1	1	GO:0005834;GO:0005886;GO:0007186;GO:0031681		Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. {ECO:0000305}.
Q4G0G2	H1-10-AS1	97	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2006-12-12	0	0	Putative uncharacterized protein H1-10-AS1 (H1-10 antisense RNA 1) (H1FX antisense RNA 1)	0	0	0	0	0	0	0		0	0	0			
Q14602	ID2B	36	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-07-01	0	0	Putative DNA-binding protein inhibitor ID-2B (Inhibitor of DNA binding 2B)	2	0	0	0	0	0	1		0	0	0			
O15225	INE1	51	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	1999-07-15	0	0	Putative inactivation escape 1 protein	3	0	0	0	0	0	1		0	0	0			
Q8NEE0	KLHL30-AS1	82	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2006-12-12	0	0	Putative uncharacterized protein KLHL30-AS1 (KLHL30 antisense RNA 1)	0	0	0	0	0	0	0		0	0	0			
Q86SY8	KTN1-AS1	53	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2007-07-24	0	0	Putative uncharacterized protein KTN1-AS1 (KTN1 antisense RNA 1) (KTN1 antisense gene protein 1)	0	0	0	0	0	0	0		0	0	0			
A0A1B0GWH6	LASP1NB	25	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2023-05-03	0	1	LASP1 neighbor protein (Long intergenic non-protein coding RNA 672)	1	1	0	0	1	0	0		0	0	1	GO:0016020		May play a key role in the skin fibroblasts (FBs)-keratinocyte-like cells (KLCs). {ECO:0000269|PubMed:31410210}.
P58513	LINC00158	81	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2002-01-23	0	0	Putative uncharacterized protein encoded by LINC00158	0	0	0	0	0	0	0		0	0	0			
Q96KT6	LINC00208	92	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2005-07-19	0	0	Putative uncharacterized protein encoded by LINC00208	0	0	0	0	0	0	0		0	0	0			
Q8NCQ3	LINC00301	95	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2006-12-12	0	1	Putative uncharacterized protein encoded by LINC00301	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q8TCZ7	LINC00308	52	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2004-03-15	0	0	Putative uncharacterized protein encoded by LINC00308	0	0	0	0	0	0	0		0	0	0			
P59036	LINC00310	64	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2002-10-19	0	0	Putative uncharacterized protein encoded by LINC00310	0	0	0	0	0	0	0		0	0	0			
Q9Y6C7	LINC00312	94	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2000-05-30	0	0	Putative uncharacterized protein encoded by LINC00312 (Loss of heterozygosity 3 chromosomal region 2 gene A protein)	0	0	0	0	0	0	0		0	0	0			
P59037	LINC00313	77	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2002-10-19	0	0	Putative uncharacterized protein encoded by LINC00313	0	0	0	0	0	0	0		0	0	0			
Q9BZP3	LINC00470	86	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-04-08	0	0	Putative uncharacterized protein encoded by LINC00470	3	0	0	0	0	0	1		0	0	0			
Q9P2X8	LINC00474	69	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2005-07-19	0	0	Putative uncharacterized protein encoded by LINC00474 (Protein EST-YD1)	3	0	0	0	0	0	1		0	0	0			
Q96FQ7	LINC00526	95	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2005-07-05	0	0	Putative uncharacterized protein encoded by LINC00526	7	0	0	0	0	0	1		0	0	0			
Q6W349	LINC00575	94	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-03-18	0	0	Putative uncharacterized protein encoded by LINC00575	0	0	0	0	0	0	0		0	0	0			
B1AMM8	LINC00587	73	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2010-03-23	0	0	Putative uncharacterized protein encoded by LINC00587	0	0	0	0	0	0	0		0	0	0			
Q9H2U6	LINC00597	94	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2005-07-19	0	0	Putative uncharacterized protein encoded by LINC00597	0	0	0	0	0	0	0		0	0	0			
A6NCI5	LINC00862	91	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-01-15	0	1	Putative transmembrane protein encoded by LINC00862 (Small integral membrane protein 16)	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q5VT33	LINC01545	79	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2007-01-09	0	0	Putative uncharacterized protein encoded by LINC01545	0	0	0	0	0	0	0		0	0	0			
A6NGU7	LINC01546	62	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-04-08	0	0	Putative uncharacterized protein encoded by LINC01546	0	0	0	0	0	0	0		0	0	0			
A6NIU2	LINC01549	74	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2007-10-23	0	0	Putative uncharacterized protein encoded by LINC01549	0	0	0	0	0	0	0		0	0	0			
Q52M75	LINC01554	96	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2007-10-02	0	0	Putative uncharacterized protein encoded by LINC01554 (Protein FIS)	0	0	0	0	0	0	0		0	0	0			
Q5JQF7	LINC01556	62	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2007-11-13	0	0	Putative uncharacterized protein encoded by LINC01556	0	0	0	0	0	0	0		0	0	0			
Q8TB33	LINC01560	94	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2008-04-08	0	0	Putative uncharacterized protein encoded by LINC01560	0	0	0	0	0	0	0		0	0	0			
Q5TEZ4	LINC01590	76	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2007-10-02	0	0	Putative uncharacterized protein encoded by LINC01590 (Long intergenic non-protein coding RNA 1590)	0	0	0	0	0	0	0		0	0	0			
P0CE67	LINC02877	100	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2010-03-23	0	0	Putative uncharacterized protein encoded by LINC02877	0	0	0	0	0	0	0		0	0	0			
A6NGG3	LINC03041	77	sORF-class microprotein, putative (no protein-level evidence)	Predicted	2.0	2008-02-05	0	0	Putative uncharacterized protein encoded by LINC03041 (Long intergenic non-protein coding RNA 3041)	0	0	0	0	0	0	0		0	0	0			
A4D0Y5	LINC03043	90	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2011-10-19	0	0	Uncharacterized protein encoded by LINC03043 (Long intergenic non-protein coding RNA 3043)	0	0	0	0	0	0	0		0	0	0			
A0A1B0GVX0	LITAFD	72	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2019-06-05	0	0	LITAF domain-containing protein (LITAF-like protein)	6	6	0	5	1	0	0		1	1	1	GO:0001817;GO:0005634;GO:0008270;GO:0016020;GO:0098560;GO:0098574		
Q75NE6	MIR17HG	70	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	2007-02-06	0	1	Putative microRNA 17 host gene protein (Putative microRNA host gene 1 protein)	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q0VDD5	MIR22HG	57	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-02-05	0	0	Putative uncharacterized protein encoded by MIR22HG	0	0	0	0	0	0	0		0	0	0			
A0A0U1RRN3	MISFA	59	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	3.0	2018-06-20	0	1	Mitochondrial sheath formation-associated protein (Putative transmembrane protein SPTY2D1OS) (SPTY2D1 antisense RNA 1) (SPTY2D1 opposite strand)	2	2	0	0	1	1	0		0	0	1	GO:0005741		[Isoform Kastor]: Regulates sperm development. May be involved in mitochondrial sheath formation. {ECO:0000250|UniProtKB:Q8C5Y2}.; [Isoform Polluks]: Regulates sperm development. May be involved in mitochondrial sheath formation. {ECO:0000250|UniProtKB:Q8C5Y2}.
Q6NVV0	MKRN9P	33	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-07-01	0	0	Putative makorin-5 (Makorin ring finger protein pseudogene 6) (Makorin ring finger protein pseudogene 9) (Putative RING finger protein 65)	0	0	0	0	0	0	0		0	0	0			
P0C6P0	NBEAP1	100	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-03-18	0	0	Putative protein BCL8 (Neurobeachin pseudogene 1)	0	0	0	0	0	0	0		0	0	0			
P0DMW2	NLRP2B	45	sORF-class microprotein, putative (no protein-level evidence)	Evidence at transcript level	5.0	2015-05-27	0	0	NLR family pyrin domain-containing protein 2B (Pyrin domain-containing protein 2-like protein POP4) (Pyrin-only protein 4)	9	9	7	0	2	0	0	CP	0	1	1	GO:0005634;GO:0005737;GO:0010804;GO:0033137;GO:0034122;GO:0043065;GO:0045786	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804, IMP]; negative regulation of peptidyl-serine phosphorylation [GO:0033137, IMP]; negative regulation of toll-like receptor signaling pathway [GO:0034122, IMP]; positive regulation of apoptotic process [GO:0043065, IMP]; negative regulation of cell cycle [GO:0045786, IMP]	May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate im
O15428	PIN1P1	100	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2000-05-30	0	0	Putative PIN1-like protein (Peptidylprolyl cis-trans isomerase NIMA-interacting 1 pseudogene 1)	3	0	0	0	0	0	1		0	0	0			
Q16048	PMCHL1	86	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	1999-07-15	0	0	Putative pro-MCH-like protein 1 (Pro-MCH variant) (Pro-melanin-concentrating hormone-like protein 1)	7	7	0	2	4	1	0		1	1	1	GO:0005576;GO:0007165;GO:0007268;GO:0030354;GO:0031777;GO:0032227;GO:0045202		
Q9BQD1	PMCHL2	86	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	2005-07-19	0	0	Putative pro-MCH-like protein 2 (Pro-melanin-concentrating hormone-like protein 2)	6	6	0	2	4	0	0		1	1	1	GO:0007165;GO:0007268;GO:0030354;GO:0031777;GO:0032227;GO:0045202		
Q5T3Y7	POPDC1-AS1	98	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2010-06-15	0	0	Putative uncharacterized protein POPDC1-AS1 (BVES antisense RNA 1) (BVES antisense gene protein 1)	0	0	0	0	0	0	0		0	0	0			
Q9NRI7	PPY2P	21	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-01-15	0	0	Putative pancreatic polypeptide 2	0	0	0	0	0	0	0		0	0	0			
D3DTV9	PRAC2	90	sORF-class microprotein, putative (no protein-level evidence)	Evidence at transcript level	2.0	2014-11-26	0	0	Protein PRAC2 (Prostate, rectum and colon expressed gene protein 2)	2	2	1	0	1	0	0	C	0	0	1	GO:0005634	nucleus [GO:0005634, EXP]	
O15172	PSPHP1	72	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-02-05	0	0	Putative phosphoserine phosphatase-like protein (L-3-phosphoserine-phosphatase homolog)	0	0	0	0	0	0	0		0	0	0			
Q0P140		79	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-07-01	0	0	Putative uncharacterized protein HSD52	0	0	0	0	0	0	0		0	0	0			
Q1T7F1		81	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2013-05-01	0	0	Putative chemokine-related protein B42	1	1	0	0	1	0	0		0	0	1	GO:0005737		
Q5VSD8		79	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2008-07-01	0	0	Putative uncharacterized protein LOC401522	0	0	0	0	0	0	0		0	0	0			
Q8IZM0		81	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-05-20	0	0	Putative CNGA1-overlapping antisense gene protein (Anti-CNG1)	0	0	0	0	0	0	0		0	0	0			
Q96IR3		41	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2006-10-31	0	0	Putative uncharacterized protein MGC15705	0	0	0	0	0	0	0		0	0	0			
Q9BTK2		45	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2006-10-31	0	0	Putative uncharacterized protein LOC642776	0	0	0	0	0	0	0		0	0	0			
Q9BZS9		49	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-07-01	0	0	Putative uncharacterized protein PNAS-138	0	0	0	0	0	0	0		0	0	0			
Q9H379		93	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-03-18	0	0	Putative uncharacterized protein PRO3102	0	0	0	0	0	0	0		0	0	0			
Q9H521		79	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-02-26	0	0	Putative uncharacterized protein LOC645739	0	0	0	0	0	0	0		0	0	0			
Q9P1D8		64	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-02-26	0	0	Putative uncharacterized protein PRO2289	0	0	0	0	0	0	0		0	0	0			
Q9UHT4		67	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2000-12-01	0	0	Putative uncharacterized protein PRO1854	0	0	0	0	0	0	0		0	0	0			
Q9UHU1		43	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-07-01	0	0	Putative uncharacterized protein PRO1716	0	0	0	0	0	0	0		0	0	0			
Q9UI25		63	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2000-12-01	0	0	Putative uncharacterized protein PRO0461	0	0	0	0	0	0	0		0	0	0			
Q9UI54		55	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2000-12-01	0	0	Putative uncharacterized protein PRO0628	0	0	0	0	0	0	0		0	0	0			
Q9UI72		69	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-04-29	0	0	Putative uncharacterized protein PRO0255	0	0	0	0	0	0	0		0	0	0			
Q9Y3F1		56	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2000-12-01	0	0	Putative TAP2-associated 6.5 kDa polypeptide	0	0	0	0	0	0	0		0	0	0			May be associated with TAP2 isoform activity.
Q0VG73	RDUR	95	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2008-06-10	0	0	Putative protein RDUR (RIG-I dependent antiviral response regulator RNA)	1	0	0	0	0	0	1		0	0	0			Could play a role in innate immunity against viruses. {ECO:0000269|PubMed:34054851}.
Q9BWJ2	RHPN1-AS1	59	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2007-01-09	0	0	Putative uncharacterized protein encoded by RHPN1-AS1 (RHPN1 antisense RNA 1) (RHPN1 antisense gene protein 1)	1	0	0	0	0	0	1		0	0	0			
Q6NUR6	RNF216P1	42	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2008-03-18	0	0	Putative protein RNF216-like	0	0	0	0	0	0	0		0	0	0			
C0HM01	SEPTIN14P20	71	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	2022-05-25	0	0	Putative RNA-binding regulatory peptide (RBRP) (Septin 14 pseudogene 20)	3	2	2	0	0	0	0	P	0	1	0	GO:0048255;GO:1902416	mRNA stabilization [GO:0048255, IDA]; positive regulation of mRNA binding [GO:1902416, IDA]	Enhances binding of IGF2BP1 to N6-methyladenosine (m6A)-containing mRNAs, thereby contributing to increased mRNA stability (PubMed:32245947). Also increases the interaction of IGF2BP1 with RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1, and increases the interaction of RNA stabilizers ELAVL1/HUR, MATR
A0A1B0GWG4	SERTM2	90	sORF-class microprotein, putative (no protein-level evidence)	Evidence at transcript level	3.0	2018-02-28	0	1	Serine-rich and transmembrane domain-containing protein 2	3	3	0	0	2	1	0		0	0	1	GO:0005737;GO:0005886		Promotes GDNF-mediated spinal cord motor neuron subtype specification, ensuring the maintenance of ETV4-expressing motor neurons. Affects the resting membrane potential and excitability of motor neurons. {ECO:0000250|UniProtKB:A0A1B0GSN8}.
Q9Y6J3	SMAD5-AS1	95	sORF-class microprotein, putative (no protein-level evidence)	Evidence at transcript level	2.0	2000-12-01	0	0	SMAD5 antisense gene protein 1 (10.3 kDa proline-rich protein DAMS) (SMAD5 antisense RNA 1) (SMAD5 opposite strand protein)	1	1	0	0	0	1	0		0	1	0	GO:0007165		
P0DMW4	SMIM10L2A	78	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2015-06-24	0	0	Small integral membrane protein 10-like protein 2A	0	0	0	0	0	0	0		0	0	0			
P0DMW5	SMIM10L2B	78	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2015-06-24	0	0	Small integral membrane protein 10-like protein 2B	0	0	0	0	0	0	0		0	0	0			
A0A0C4DGP1	SMIM10L3	68	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2024-05-29	0	0	Small integral membrane protein 10-like protein 3 (Salivary gland-specific protein SAGSIN1)	0	0	0	0	0	0	0		0	0	0			
A0A1B0GVY4	SMIM31	71	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2018-02-28	0	1	Small integral membrane protein 31	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A1B0GVV1	SMIM35	85	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2018-02-28	0	1	Small integral membrane protein 35 (TMPRSS4 antisense RNA 1)	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A286YFK9	SMIM38	51	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2019-02-13	0	1	Small integral membrane protein 38	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A1B0GW54	SMIM39	56	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2019-01-16	0	1	Small integral membrane protein 39	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A5F9ZH02	SMIM42	70	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2020-12-02	0	1	Small integral membrane protein 42	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A0A590UK83	SMIM45	68	sORF-class microprotein, putative (no protein-level evidence)	Evidence at transcript level	3.0	2022-02-23	0	1	Small integral membrane protein 45	6	6	3	0	3	0	0	CP	0	1	1	GO:0005634;GO:0005737;GO:0016020;GO:0042551	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; neuron maturation [GO:0042551, IMP]	Plays a role in the regulation of neuron maturation. {ECO:0000269|PubMed:36593289}.
P0DQW1	SMIM46	50	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2022-12-14	0	1	Small integral membrane protein 46	3	1	0	0	1	0	0		0	0	1	GO:0016020		
D0EPY3	SMIM47	28	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2023-02-22	0	1	Small integral membrane protein 47	1	1	0	0	1	0	0		0	0	1	GO:0016020		
H3BMG3	SMKR1	65	sORF-class microprotein, putative (no protein-level evidence)	Predicted	1.0	2013-03-06	0	0	Small lysine-rich protein 1	0	0	0	0	0	0	0		0	0	0			
Q9BXW3	SNHG12	62	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2007-02-20	0	0	Putative uncharacterized protein SNHG12 (Transformation-related gene 11 protein) (TRG-11)	0	0	0	0	0	0	0		0	0	0			
A8MWD9	SNRPGP15	76	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	2008-09-02	0	0	Putative small nuclear ribonucleoprotein G-like protein 15	18	18	0	13	5	0	0		1	1	1	GO:0000398;GO:0003723;GO:0005634;GO:0005681;GO:0005682;GO:0005685;GO:0005686;GO:0005687;GO:0005689;GO:0030532;GO:0034719;GO:0043186;GO:0071004;GO:0071011;GO:0071013;GO:0097526		Associated with snRNP U1, U2, U4/U6 and U5. {ECO:0000250}.
P0CW21	SPART-AS1	52	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2011-05-31	0	0	Putative uncharacterized protein SPART-AS1 (SPART antisense RNA 1) (SPG20 antisense RNA 1) (SPG20 opposite strand transcript protein)	0	0	0	0	0	0	0		0	0	0			
A0A024R1R8	TMA7B	64	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2023-02-22	0	0	Translation machinery-associated protein 7B	0	0	0	0	0	0	0		0	0	0			
P0DX04	TMSB15C	45	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	2.0	2023-02-22	0	0	Thymosin beta-15C	3	3	0	0	3	0	0		1	1	1	GO:0003785;GO:0005856;GO:0007015		Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G-actin) and therefore inhibits actin polymerization. {ECO:0000250|UniProtKB:P62328}.
Q9BZA0	TTTY10	68	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2003-01-17	0	0	Putative transcript Y 10 protein	0	0	0	0	0	0	0		0	0	0			
Q9BZ98	TTTY12	90	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2003-01-17	0	0	Putative transcript Y 12 protein	0	0	0	0	0	0	0		0	0	0			
Q9BZ97	TTTY13	58	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2003-01-17	0	1	Putative transcript Y 13 protein	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q8IWF7	UBE2DNL	75	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2006-10-31	0	0	Putative ubiquitin-conjugating enzyme E2 D2-like protein (Ubiquitin carrier protein D2-like) (Ubiquitin-conjugating enzyme E2D N-terminal-like) (Ubiquitin-protein ligase D2-like)	0	0	0	0	0	0	0		0	0	0			
Q96HZ7	URB1-DT	61	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	2.0	2003-11-14	0	0	Putative uncharacterized protein URB1-DT (URB1 antisense RNA 1) (URB1 antisense gene protein 1) (URB1 divergent transcript)	3	0	0	0	0	0	1		0	0	0			
P0C5K6	VENTXP1	33	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	1.0	2007-10-23	0	0	Putative tumor antigen NA88-A (Cancer/testis antigen 18) (CT18)	0	0	0	0	0	0	0		0	0	0			
Q06250	WT1-AS	92	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	1995-11-01	0	0	Putative Wilms tumor upstream neighbor 1 gene protein (WIT-1) (Wilms tumor-associated antisense RNA)	10	0	0	0	0	0	1		0	0	0			
A0A0U1RRA0	ZNF593OS	63	sORF-class microprotein, putative (no protein-level evidence)	Inferred from homology	1.0	2021-02-10	0	1	Transmembrane protein ZNF593OS (ZNF593 opposite strand protein)	1	1	0	0	1	0	0		0	0	1	GO:0016020		
Q6ZQV5	ZNF788P	82	sORF-class microprotein, putative (no protein-level evidence)	Uncertain	3.0	2007-07-10	0	0	Putative KRAB domain-containing protein ZNF788 (Zinc finger family member 788, pseudogene)	2	2	1	0	1	0	0	C	0	1	1	GO:0005634;GO:0006355	nucleus [GO:0005634, HDA]	
A8MTW9		85	secreted peptide / hormone / defensin	Uncertain	2.0	2008-06-10	1	0	Putative uncharacterized protein ENSP00000380674	1	1	0	0	1	0	0		0	0	1	GO:0005576		
P0DMC3	APELA	54	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2014-02-19	1	0	Apelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler)	34	34	13	0	4	17	0	CFP	1	1	1	GO:0001570;GO:0005179;GO:0005576;GO:0007186;GO:0007492;GO:0007507;GO:0007509;GO:0007512;GO:0031704;GO:0035050;GO:0045766;GO:0045823;GO:0060183;GO:0060674;GO:0060976;GO:0070374;GO:0090133;GO:0090134;GO:1901165;GO:1903589;GO:1904022	hormone activity [GO:0005179, IDA]; hormone activity [GO:0005179, IMP]; extracellular region [GO:0005576, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IDA]; apelin receptor binding [GO:0031704, IDA]; positive regulation of angiogenesis [GO:0045766, IMP]; apelin receptor signaling pathway [GO:0060183, IDA]; apelin receptor signaling pathway [GO:0060183, IMP]; positive regulation of trophoblast cell migration [GO:1901165, IMP]; positive regulation of G protein-coupled receptor internalization [GO:1904022, IMP]	Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:25639753, PubMed:28137936, PubMed:35817871). Functions as a balanced agonist activating both 
Q9ULZ1	APLN	77	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2002-01-23	1	0	Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13]	51	51	23	1	13	14	0	CFP	1	1	1	GO:0005102;GO:0005179;GO:0005576;GO:0006955;GO:0007165;GO:0007595;GO:0010629;GO:0031704;GO:0040037;GO:0042756;GO:0045776;GO:0045823;GO:0060183;GO:0060976;GO:1902895;GO:1904022;GO:1904706;GO:1905564	hormone activity [GO:0005179, IDA]; hormone activity [GO:0005179, IMP]; extracellular region [GO:0005576, IDA]; negative regulation of gene expression [GO:0010629, IGI]; apelin receptor binding [GO:0031704, IDA]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037, IGI]; apelin receptor signaling pathway [GO:0060183, IDA]; apelin receptor signaling pathway [GO:0060183, IMP]; positive regulation of miRNA transcription [GO:1902895, IDA]; positive regulation of G protein-coupled receptor internalization [GO:1904022, IDA]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706, IMP]; positive regulation of vascular endothelial cell proliferation [GO:1905564, IDA]	Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis (PubMed:10525157, PubMed:22810587, PubMed:35817871, PubMed:38428423). Functions as a balanced agonist activating both G(i) protein pathway and bet
P02652	APOA2	100	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))]	110	90	57	4	8	21	0	CFP	1	1	1	GO:0002719;GO:0005102;GO:0005319;GO:0005543;GO:0005576;GO:0005769;GO:0005788;GO:0005829;GO:0006641;GO:0006656;GO:0006869;GO:0007165;GO:0008035;GO:0008289;GO:0009395;GO:0009749;GO:0010903;GO:0015485;GO:0018158;GO:0018206;GO:0019899;GO:0030301;GO:0031072;GO:0031210;GO:0031647;GO:0032375;GO:0032757;GO:0033344;GO:0033700;GO:0034190;GO:0034361;GO:0034364;GO:0034366;GO:0034370;GO:0034374;GO:0034375;GO:0034380;GO:0034384;GO:0042157;GO:0042627;GO:0042632;GO:0042803;GO:0043691;GO:0046340;GO:0046982;GO:0048018;GO:0050766;GO:0050821;GO:0050995;GO:0050996;GO:0055102;GO:0060228;GO:0060621;GO:0070062;GO:0070653;GO:0071402;GO:0072562;GO:0120020	negative regulation of cytokine production involved in immune response [GO:0002719, IDA]; signaling receptor binding [GO:0005102, IPI]; lipid carrier activity [GO:0005319, IDA]; phospholipid binding [GO:0005543, IDA]; extracellular region [GO:0005576, EXP]; phosphatidylcholine biosynthetic process [GO:0006656, IDA]; lipid binding [GO:0008289, IDA]; phospholipid catabolic process [GO:0009395, IDA]; response to glucose [GO:0009749, IDA]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903, IDA]; cholesterol binding [GO:0015485, IDA]; protein oxidation [GO:0018158, IDA]; peptidyl-methionine modification [GO:0018206, IDA]; enzyme binding [GO:0019899, IPI]; heat shock protein binding [GO:0031072, IPI]; phosphatidylcholine binding [GO:0031210, IDA]; regulation of protein stability [GO:0031647, IDA]; negative regulation of cholesterol transport [GO:0032375, IMP]; positive regulation of interleukin-8 production [GO:0032757, IDA]; cholesterol efflux [GO:0033344, IDA]; phospholipid efflux [GO:0033700, IDA]; apolipoprotein receptor binding [GO:0034190, IPI]; very-low-density lipoprotein particle [GO:0034361, IDA]; high-density lipoprotein particle [GO:0034364, IDA]; spherical high-density lipoprotein particle [GO:0034366, IDA]; triglyceride-rich lipoprotein particle remodeling [GO:0034370, IDA]; low-density lipoprotein particle remodeling [GO:0034374, IDA]; high-density lipoprotein particle remodeling [GO:0034375, IDA]; high-density lipoprotein particle assembly [GO:0034380, IDA]; high-density lipoprotein particle clearance [GO:0034384, IDA]; chylomicron [GO:0042627, IDA]; cholesterol homeostasis [GO:0042632, IDA]; protein homodimerization activity [GO:0042803, IDA]; reverse cholesterol transport [GO:0043691, IDA]; diacylglycerol catabolic process [GO:0046340, IDA]; protein heterodimerization activity [GO:0046982, IPI]; receptor ligand activity [GO:0048018, IDA]; positive regulation of phagocytosis [GO:0050766, IDA]; protein stabilization [GO:0050821, IDA]; negative regulation of lipid catabolic process [GO:0050995, IDA]; positive regulation of lipid catabolic process [GO:0050996, IDA]; lipase inhibitor activity [GO:0055102, IDA]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228, IDA]; negative regulation of cholesterol import [GO:0060621, IDA]; extracellular exosome [GO:0070062, HDA]; high-density lipoprotein particle receptor binding [GO:0070653, IPI]; cellular response to lipoprotein particle stimulus [GO:0071402, IDA]; blood microparticle [GO:0072562, HDA]; cholesterol transfer activity [GO:0120020, IDA]	May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
P02654	APOC1	83	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]	70	45	22	9	3	11	0	CFP	1	1	1	GO:0004859;GO:0005504;GO:0005576;GO:0005783;GO:0006629;GO:0006641;GO:0010897;GO:0010900;GO:0010916;GO:0031210;GO:0032374;GO:0032375;GO:0033344;GO:0033700;GO:0034361;GO:0034364;GO:0034369;GO:0034375;GO:0034379;GO:0034382;GO:0034447;GO:0042157;GO:0042627;GO:0045717;GO:0045833;GO:0048261;GO:0050995;GO:0055102;GO:0060228;GO:0070328	phospholipase inhibitor activity [GO:0004859, IDA]; fatty acid binding [GO:0005504, IDA]; endoplasmic reticulum [GO:0005783, IDA]; negative regulation of triglyceride catabolic process [GO:0010897, IDA]; negative regulation of phosphatidylcholine catabolic process [GO:0010900, IDA]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916, IDA]; regulation of cholesterol transport [GO:0032374, IDA]; negative regulation of cholesterol transport [GO:0032375, IDA]; cholesterol efflux [GO:0033344, IDA]; phospholipid efflux [GO:0033700, IDA]; very-low-density lipoprotein particle [GO:0034361, IDA]; high-density lipoprotein particle [GO:0034364, IDA]; plasma lipoprotein particle remodeling [GO:0034369, IDA]; chylomicron remnant clearance [GO:0034382, IDA]; very-low-density lipoprotein particle clearance [GO:0034447, IDA]; negative regulation of fatty acid biosynthetic process [GO:0045717, IDA]; negative regulation of lipid metabolic process [GO:0045833, IDA]; negative regulation of receptor-mediated endocytosis [GO:0048261, IDA]; negative regulation of lipid catabolic process [GO:0050995, IDA]; lipase inhibitor activity [GO:0055102, IDA]; triglyceride homeostasis [GO:0070328, IDA]	Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protei
P02656	APOC3	99	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)	81	78	43	14	5	16	0	CFP	1	1	1	GO:0005543;GO:0005576;GO:0005769;GO:0006641;GO:0006869;GO:0007186;GO:0008289;GO:0010897;GO:0010903;GO:0010916;GO:0010987;GO:0010989;GO:0015485;GO:0019433;GO:0032489;GO:0033344;GO:0033700;GO:0034361;GO:0034363;GO:0034366;GO:0034375;GO:0034379;GO:0034382;GO:0042157;GO:0042627;GO:0042632;GO:0043691;GO:0045717;GO:0045833;GO:0048261;GO:0050995;GO:0055102;GO:0060621;GO:0070062;GO:0070328;GO:0070653	phospholipid binding [GO:0005543, IDA]; extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; triglyceride metabolic process [GO:0006641, IMP]; lipid transport [GO:0006869, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IDA]; negative regulation of triglyceride catabolic process [GO:0010897, IDA]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903, IDA]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916, IDA]; negative regulation of high-density lipoprotein particle clearance [GO:0010987, IMP]; negative regulation of low-density lipoprotein particle clearance [GO:0010989, IMP]; triglyceride catabolic process [GO:0019433, IDA]; regulation of Cdc42 protein signal transduction [GO:0032489, IDA]; cholesterol efflux [GO:0033344, IDA]; phospholipid efflux [GO:0033700, IDA]; very-low-density lipoprotein particle [GO:0034361, IDA]; intermediate-density lipoprotein particle [GO:0034363, IDA]; spherical high-density lipoprotein particle [GO:0034366, IDA]; high-density lipoprotein particle remodeling [GO:0034375, IMP]; chylomicron remnant clearance [GO:0034382, IDA]; chylomicron [GO:0042627, IDA]; cholesterol homeostasis [GO:0042632, IMP]; negative regulation of fatty acid biosynthetic process [GO:0045717, IDA]; negative regulation of lipid metabolic process [GO:0045833, IDA]; negative regulation of receptor-mediated endocytosis [GO:0048261, IDA]; negative regulation of lipid catabolic process [GO:0050995, IDA]; lipase inhibitor activity [GO:0055102, IDA]; negative regulation of cholesterol import [GO:0060621, IMP]; extracellular exosome [GO:0070062, HDA]; triglyceride homeostasis [GO:0070328, IMP]; high-density lipoprotein particle receptor binding [GO:0070653, IPI]	Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprote
Q13072	BAGE	43	secreted peptide / hormone / defensin	Evidence at protein level	3.0	1999-07-15	1	0	B melanoma antigen 1 (B melanoma antigen) (Antigen MZ2-BA) (Cancer/testis antigen 2.1) (CT2.1)	6	1	0	0	1	0	0		0	0	1	GO:0005576		Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Q86Y28	BAGE4	39	secreted peptide / hormone / defensin	Evidence at transcript level	2.0	2003-10-03	1	0	B melanoma antigen 4 (Cancer/testis antigen 2.4) (CT2.4)	1	1	0	0	1	0	0		0	0	1	GO:0005576		Unknown. Candidate gene encoding tumor antigens.
Q86Y27	BAGE5	43	secreted peptide / hormone / defensin	Evidence at transcript level	2.0	2003-10-03	1	0	B melanoma antigen 5 (Cancer/testis antigen 2.5) (CT2.5)	1	1	0	0	1	0	0		0	0	1	GO:0005576		Unknown. Candidate gene encoding tumor antigens.
P02818	BGLAP	100	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein)	71	70	4	5	35	26	0	CP	1	1	1	GO:0001501;GO:0001503;GO:0001649;GO:0001956;GO:0005179;GO:0005198;GO:0005509;GO:0005576;GO:0005737;GO:0005788;GO:0005796;GO:0007155;GO:0007165;GO:0007420;GO:0007611;GO:0008147;GO:0009410;GO:0009612;GO:0009629;GO:0010043;GO:0014823;GO:0030282;GO:0030425;GO:0030500;GO:0031667;GO:0031982;GO:0032571;GO:0032868;GO:0032869;GO:0033280;GO:0033574;GO:0033594;GO:0034224;GO:0036005;GO:0042593;GO:0043204;GO:0043627;GO:0044342;GO:0045124;GO:0045471;GO:0045670;GO:0046848;GO:0048731;GO:0048863;GO:0050890;GO:0051384;GO:0060348;GO:0071305;GO:0071363;GO:0140144;GO:1900076;GO:1903011;GO:2000224	osteoblast differentiation [GO:0001649, IEP]; extracellular region [GO:0005576, EXP]; cytoplasm [GO:0005737, IDA]; response to vitamin D [GO:0033280, IEP]	The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:3019668, PubMed:6967872). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralizatio
Q0P5P2	C17orf67	90	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2007-05-15	1	0	Uncharacterized protein C17orf67	4	1	0	0	1	0	0		0	0	1	GO:0005576		
A0A1B0GTC6	C3orf85	90	secreted peptide / hormone / defensin	Evidence at protein level	1.0	2018-01-31	1	0	Uncharacterized protein C3orf85	0	0	0	0	0	0	0		0	0	0			
Q6UWT4	C5orf46	87	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2008-02-05	1	0	Uncharacterized protein C5orf46	16	2	1	0	1	0	0	C	0	0	1	GO:0005576;GO:0070062	extracellular exosome [GO:0070062, HDA]	
P22362	CCL1	96	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1991-08-01	1	0	C-C motif chemokine 1 (Small-inducible cytokine A1) (T lymphocyte-secreted protein I-309)	33	33	9	8	6	10	0	CFP	1	1	1	GO:0005125;GO:0005576;GO:0006874;GO:0006935;GO:0006954;GO:0006955;GO:0007165;GO:0007204;GO:0008009;GO:0016032;GO:0030335;GO:0031640;GO:0032740;GO:0048020;GO:0048245;GO:0050729;GO:0061844;GO:0070098;GO:0090026	extracellular region [GO:0005576, IDA]; positive regulation of cytosolic calcium ion concentration [GO:0007204, IDA]; chemokine activity [GO:0008009, IDA]; killing of cells of another organism [GO:0031640, IDA]; positive regulation of interleukin-17 production [GO:0032740, IDA]; positive regulation of inflammatory response [GO:0050729, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; positive regulation of monocyte chemotaxis [GO:0090026, IDA]	Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. {ECO:0000269|PubMed:1557400}.
P51671	CCL11	97	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1996-10-01	1	0	Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)	62	53	17	8	16	12	0	CFP	1	1	1	GO:0001938;GO:0002544;GO:0002551;GO:0005576;GO:0006468;GO:0006874;GO:0006935;GO:0006954;GO:0006955;GO:0007010;GO:0007015;GO:0007155;GO:0007165;GO:0007611;GO:0008009;GO:0008360;GO:0009314;GO:0009615;GO:0030335;GO:0030838;GO:0031640;GO:0031728;GO:0035962;GO:0045766;GO:0046983;GO:0048018;GO:0048020;GO:0048245;GO:0050768;GO:0060326;GO:0061844;GO:0070098;GO:0070371;GO:0070670	positive regulation of endothelial cell proliferation [GO:0001938, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; cytoskeleton organization [GO:0007010, IDA]; chemokine activity [GO:0008009, IDA]; regulation of cell shape [GO:0008360, IDA]; positive regulation of cell migration [GO:0030335, IDA]; positive regulation of actin filament polymerization [GO:0030838, IDA]; killing of cells of another organism [GO:0031640, IDA]; CCR3 chemokine receptor binding [GO:0031728, IDA]; protein dimerization activity [GO:0046983, IDA]; receptor ligand activity [GO:0048018, IDA]; eosinophil chemotaxis [GO:0048245, IDA]; cell chemotaxis [GO:0060326, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; chemokine-mediated signaling pathway [GO:0070098, IDA]	Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells (PubMed:8597956, PubMed:33846499). Exerts its effects primarily by binding to the CCR3
Q99616	CCL13	98	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1998-07-15	1	0	C-C motif chemokine 13 (CK-beta-10) (Monocyte chemoattractant protein 4) (Monocyte chemotactic protein 4) (MCP-4) (NCC-1) (Small-inducible cytokine A13) [Cleaved into: C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain]	40	32	6	8	4	14	0	FP	1	1	1	GO:0005102;GO:0005576;GO:0006874;GO:0006935;GO:0006954;GO:0006955;GO:0007010;GO:0007165;GO:0007267;GO:0008009;GO:0008360;GO:0030335;GO:0031640;GO:0048020;GO:0048245;GO:0061844;GO:0070098	cytoskeleton organization [GO:0007010, IDA]; chemokine activity [GO:0008009, IDA]; regulation of cell shape [GO:0008360, IDA]; killing of cells of another organism [GO:0031640, IDA]; eosinophil chemotaxis [GO:0048245, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes i
Q16627	CCL14	93	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1997-11-01	1	0	C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)]	15	15	0	8	4	3	0		1	1	1	GO:0005576;GO:0006874;GO:0006954;GO:0006955;GO:0008009;GO:0008284;GO:0030335;GO:0048020;GO:0060326;GO:0061844;GO:0070098		Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the prol
Q92583	CCL17	94	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1998-07-15	1	0	C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)	27	18	6	0	5	7	0	CP	1	1	1	GO:0005102;GO:0005576;GO:0006935;GO:0006955;GO:0007267;GO:0008009;GO:0031640;GO:0060326;GO:0061844	extracellular region [GO:0005576, EXP]; killing of cells of another organism [GO:0031640, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (Pu
P55774	CCL18	89	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1997-11-01	1	0	C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]	22	21	3	8	4	6	0	P	1	1	1	GO:0005576;GO:0006935;GO:0006954;GO:0006955;GO:0007154;GO:0007165;GO:0007267;GO:0008009;GO:0030335;GO:0031640;GO:0048020;GO:0060326;GO:0061844;GO:0070098	killing of cells of another organism [GO:0031640, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and
Q99731	CCL19	98	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1997-11-01	1	0	C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19)	73	71	26	8	5	32	0	FP	1	1	1	GO:0001768;GO:0001771;GO:0002407;GO:0002408;GO:0002606;GO:0005576;GO:0006874;GO:0006954;GO:0006955;GO:0007154;GO:0008009;GO:0009615;GO:0010560;GO:0030335;GO:0031295;GO:0031640;GO:0031732;GO:0031735;GO:0032489;GO:0032731;GO:0032735;GO:0032760;GO:0035022;GO:0038119;GO:0042102;GO:0042379;GO:0043123;GO:0045627;GO:0045807;GO:0046330;GO:0048020;GO:0048245;GO:0048260;GO:0048469;GO:0050921;GO:0051209;GO:0051897;GO:0060491;GO:0061844;GO:0070098;GO:0070374;GO:0071380;GO:0071731;GO:0090023;GO:0097029;GO:0098586;GO:0141214;GO:1901224;GO:2000147;GO:2000549;GO:2000669	establishment of T cell polarity [GO:0001768, IDA]; dendritic cell chemotaxis [GO:0002407, IDA]; myeloid dendritic cell chemotaxis [GO:0002408, IDA]; chemokine activity [GO:0008009, IDA]; killing of cells of another organism [GO:0031640, IDA]; CCR10 chemokine receptor binding [GO:0031735, IDA]; CCL19-activated CCR7 signaling pathway [GO:0038119, IDA]; chemokine receptor binding [GO:0042379, IDA]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, IDA]; positive regulation of JNK cascade [GO:0046330, IDA]; CCR chemokine receptor binding [GO:0048020, IPI]; release of sequestered calcium ion into cytosol [GO:0051209, IDA]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; positive regulation of ERK1 and ERK2 cascade [GO:0070374, IDA]; positive regulation of ERK1 and ERK2 cascade [GO:0070374, IMP]; cellular response to prostaglandin E stimulus [GO:0071380, IDA]; response to nitric oxide [GO:0071731, IDA]; positive regulation of neutrophil chemotaxis [GO:0090023, IDA]; cellular response to virus [GO:0098586, IMP]; positive regulation of phospholipase C/protein kinase C signal transduction [GO:0141214, IDA]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224, IDA]; positive regulation of cell motility [GO:2000147, IDA]; negative regulation of dendritic cell apoptotic process [GO:2000669, IDA]	May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL
P13500	CCL2	99	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1990-01-01	1	0	C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)	87	80	28	8	5	39	0	CFP	1	1	1	GO:0001525;GO:0002548;GO:0004672;GO:0005102;GO:0005576;GO:0006468;GO:0006935;GO:0006954;GO:0006955;GO:0006959;GO:0007010;GO:0007155;GO:0007165;GO:0007166;GO:0007186;GO:0007187;GO:0007204;GO:0007259;GO:0008009;GO:0008360;GO:0009617;GO:0009887;GO:0010628;GO:0010759;GO:0016020;GO:0019079;GO:0019221;GO:0019233;GO:0019725;GO:0030335;GO:0031727;GO:0034351;GO:0035684;GO:0038148;GO:0042056;GO:0042379;GO:0043524;GO:0043615;GO:0044344;GO:0048020;GO:0048245;GO:0048246;GO:0050870;GO:0050918;GO:0051968;GO:0061844;GO:0070098;GO:0071222;GO:0071346;GO:0071347;GO:0071356;GO:0090280;GO:1900451;GO:1905563;GO:2000134;GO:2000353;GO:2000427;GO:2000502	monocyte chemotaxis [GO:0002548, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; cytoskeleton organization [GO:0007010, IDA]; positive regulation of cytosolic calcium ion concentration [GO:0007204, IDA]; chemokine activity [GO:0008009, IDA]; regulation of cell shape [GO:0008360, IDA]; membrane [GO:0016020, IDA]; cytokine-mediated signaling pathway [GO:0019221, IDA]; negative regulation of glial cell apoptotic process [GO:0034351, IDA]; chemoattractant activity [GO:0042056, IDA]; chemokine receptor binding [GO:0042379, IDA]; negative regulation of neuron apoptotic process [GO:0043524, IDA]; astrocyte cell migration [GO:0043615, IDA]; cellular response to fibroblast growth factor stimulus [GO:0044344, IEP]; macrophage chemotaxis [GO:0048246, IDA]; chemokine-mediated signaling pathway [GO:0070098, IDA]; cellular response to type II interferon [GO:0071346, IEP]; cellular response to interleukin-1 [GO:0071347, IEP]; cellular response to tumor necrosis factor [GO:0071356, IEP]; positive regulation of calcium ion import [GO:0090280, IDA]; negative regulation of vascular endothelial cell proliferation [GO:1905563, IMP]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134, IMP]; positive regulation of endothelial cell apoptotic process [GO:2000353, IMP]; negative regulation of natural killer cell chemotaxis [GO:2000502, IDA]	Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activ
P78556	CCL20	96	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1997-11-01	1	0	C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]	49	44	20	0	10	14	0	CFP	1	1	1	GO:0005125;GO:0005576;GO:0006935;GO:0006954;GO:0006955;GO:0007165;GO:0007267;GO:0008009;GO:0019722;GO:0031640;GO:0031731;GO:0060326;GO:0061844;GO:0072678;GO:0072679;GO:2000406	extracellular region [GO:0005576, EXP]; chemotaxis [GO:0006935, IDA]; calcium-mediated signaling [GO:0019722, IDA]; killing of cells of another organism [GO:0031640, IDA]; CCR6 chemokine receptor binding [GO:0031731, IDA]; cell chemotaxis [GO:0060326, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; positive regulation of T cell migration [GO:2000406, IDA]	Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11035086, PubMed:11352563, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the ch
O00626	CCL22	93	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1999-07-15	1	0	C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]	30	29	4	8	5	12	0	CP	1	1	1	GO:0005576;GO:0006935;GO:0006954;GO:0006955;GO:0007165;GO:0007267;GO:0008009;GO:0009615;GO:0030335;GO:0031640;GO:0048020;GO:0048245;GO:0060326;GO:0061844;GO:0070098	extracellular region [GO:0005576, IDA]; killing of cells of another organism [GO:0031640, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattract
Q9Y258	CCL26	94	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2000-05-30	1	0	C-C motif chemokine 26 (CC chemokine IMAC) (Eotaxin-3) (Macrophage inflammatory protein 4-alpha) (MIP-4-alpha) (Small-inducible cytokine A26) (Thymic stroma chemokine-1) (TSC-1)	45	31	15	8	4	4	0	CFP	1	1	1	GO:0001938;GO:0002548;GO:0005576;GO:0006935;GO:0006954;GO:0006955;GO:0007165;GO:0007267;GO:0008009;GO:0010818;GO:0030335;GO:0030838;GO:0031728;GO:0031737;GO:0048018;GO:0048020;GO:0048245;GO:0050921;GO:0060326;GO:0061844;GO:0070098	positive regulation of endothelial cell proliferation [GO:0001938, IDA]; monocyte chemotaxis [GO:0002548, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; chemokine activity [GO:0008009, IDA]; T cell chemotaxis [GO:0010818, IDA]; positive regulation of cell migration [GO:0030335, IDA]; positive regulation of actin filament polymerization [GO:0030838, IDA]; CCR3 chemokine receptor binding [GO:0031728, IDA]; CX3C chemokine receptor binding [GO:0031737, IDA]; receptor ligand activity [GO:0048018, IDA]; positive regulation of chemotaxis [GO:0050921, IDA]; cell chemotaxis [GO:0060326, IDA]; chemokine-mediated signaling pathway [GO:0070098, IDA]	Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing
P10147	CCL3	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1989-07-01	1	0	C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]	96	91	66	8	5	12	0	CFP	1	1	1	GO:0000165;GO:0001649;GO:0001775;GO:0002548;GO:0004672;GO:0005576;GO:0005737;GO:0005829;GO:0006816;GO:0006874;GO:0006887;GO:0006935;GO:0006954;GO:0006955;GO:0007010;GO:0007267;GO:0008009;GO:0008360;GO:0009636;GO:0010628;GO:0010629;GO:0010818;GO:0014808;GO:0016004;GO:0016301;GO:0019722;GO:0023052;GO:0030335;GO:0030502;GO:0030593;GO:0031726;GO:0031730;GO:0032731;GO:0032760;GO:0042056;GO:0042802;GO:0043308;GO:0043525;GO:0043615;GO:0043922;GO:0045671;GO:0048020;GO:0048245;GO:0048246;GO:0048247;GO:0050729;GO:0050795;GO:0050850;GO:0050918;GO:0051897;GO:0051928;GO:0051930;GO:0060326;GO:0061844;GO:0070098;GO:0070374;GO:0070723;GO:0071346;GO:0071347;GO:0071356;GO:0071621;GO:0090280;GO:1903980;GO:1904141;GO:2000503	MAPK cascade [GO:0000165, IEP]; osteoblast differentiation [GO:0001649, IEP]; cell activation [GO:0001775, IDA]; monocyte chemotaxis [GO:0002548, IDA]; protein kinase activity [GO:0004672, IDA]; extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; calcium ion transport [GO:0006816, IDA]; intracellular calcium ion homeostasis [GO:0006874, IDA]; exocytosis [GO:0006887, IDA]; chemotaxis [GO:0006935, IDA]; inflammatory response [GO:0006954, IDA]; cytoskeleton organization [GO:0007010, IDA]; cell-cell signaling [GO:0007267, IDA]; chemokine activity [GO:0008009, IDA]; regulation of cell shape [GO:0008360, IDA]; response to toxic substance [GO:0009636, IDA]; positive regulation of gene expression [GO:0010628, IDA]; negative regulation of gene expression [GO:0010629, IDA]; T cell chemotaxis [GO:0010818, IDA]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808, IDA]; phospholipase activator activity [GO:0016004, IDA]; kinase activity [GO:0016301, IDA]; calcium-mediated signaling [GO:0019722, IDA]; signaling [GO:0023052, IEP]; positive regulation of cell migration [GO:0030335, IDA]; negative regulation of bone mineralization [GO:0030502, IDA]; neutrophil chemotaxis [GO:0030593, IDA]; CCR1 chemokine receptor binding [GO:0031726, IPI]; CCR5 chemokine receptor binding [GO:0031730, IPI]; chemoattractant activity [GO:0042056, IDA]; identical protein binding [GO:0042802, IPI]; eosinophil degranulation [GO:0043308, IDA]; host-mediated suppression of viral transcription [GO:0043922, IDA]; negative regulation of osteoclast differentiation [GO:0045671, IDA]; eosinophil chemotaxis [GO:0048245, IDA]; lymphocyte chemotaxis [GO:0048247, IDA]; regulation of behavior [GO:0050795, IDA]; positive regulation of calcium-mediated signaling [GO:0050850, IMP]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897, IEP]; positive regulation of calcium ion transport [GO:0051928, IDA]; regulation of sensory perception of pain [GO:0051930, IDA]; positive regulation of ERK1 and ERK2 cascade [GO:0070374, IDA]; response to cholesterol [GO:0070723, IDA]; cellular response to type II interferon [GO:0071346, IEP]; cellular response to interleukin-1 [GO:0071347, IEP]; cellular response to tumor necrosis factor [GO:0071356, IEP]; granulocyte chemotaxis [GO:0071621, IDA]; positive regulation of natural killer cell chemotaxis [GO:2000503, IDA]	Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:000
P16619	CCL3L1; CCL3L3	93	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1990-08-01	1	0	C-C motif chemokine 3-like 1 (G0/G1 switch regulatory protein 19-2) (LD78-beta(1-70)) (PAT 464.2) (Small-inducible cytokine A3-like 1) (Tonsillar lymphocyte LD78 beta protein) [Cleaved into: LD78-beta(3-70); LD78-beta(5-70)]	20	16	0	8	4	4	0		1	1	1	GO:0005576;GO:0006954;GO:0006955;GO:0008009;GO:0008285;GO:0030335;GO:0048020;GO:0060326;GO:0061844;GO:0070098		Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, 
P13236	CCL4	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1990-01-01	1	0	C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]	58	37	9	8	4	16	0	FP	1	1	1	GO:0005125;GO:0005576;GO:0006954;GO:0006955;GO:0007155;GO:0007163;GO:0007165;GO:0007267;GO:0008009;GO:0009615;GO:0009636;GO:0030335;GO:0031726;GO:0031730;GO:0042802;GO:0043922;GO:0048020;GO:0048245;GO:0050850;GO:0051928;GO:0061844;GO:0070098;GO:2000503	response to toxic substance [GO:0009636, IDA]; CCR1 chemokine receptor binding [GO:0031726, IPI]; CCR5 chemokine receptor binding [GO:0031730, IPI]; identical protein binding [GO:0042802, IPI]; host-mediated suppression of viral transcription [GO:0043922, IDA]; positive regulation of calcium-mediated signaling [GO:0050850, IMP]; positive regulation of calcium ion transport [GO:0051928, IDA]; positive regulation of natural killer cell chemotaxis [GO:2000503, IDA]	Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1
Q8NHW4	CCL4L1; CCL4L2	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2008-03-18	1	0	C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)	45	12	0	8	4	0	0		1	1	1	GO:0005576;GO:0006954;GO:0006955;GO:0008009;GO:0030335;GO:0048020;GO:0048245;GO:0061844;GO:0070098		Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. {ECO:0000269|PubMed:15240137}.
P13501	CCL5	91	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1990-01-01	1	0	C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]	148	115	73	8	12	22	0	CFP	1	1	1	GO:0002407;GO:0002548;GO:0002676;GO:0004435;GO:0004672;GO:0005576;GO:0005737;GO:0006816;GO:0006874;GO:0006887;GO:0006935;GO:0006954;GO:0006955;GO:0007159;GO:0007186;GO:0007267;GO:0008009;GO:0009615;GO:0009636;GO:0010759;GO:0010820;GO:0014911;GO:0016004;GO:0016020;GO:0030298;GO:0030335;GO:0031583;GO:0031726;GO:0031729;GO:0031730;GO:0032008;GO:0033634;GO:0034112;GO:0035689;GO:0042056;GO:0042102;GO:0042119;GO:0042379;GO:0042802;GO:0042803;GO:0043922;GO:0044344;GO:0045070;GO:0045071;GO:0045089;GO:0045744;GO:0045745;GO:0045785;GO:0045948;GO:0046817;GO:0048020;GO:0048245;GO:0048246;GO:0048661;GO:0050796;GO:0050863;GO:0050918;GO:0051897;GO:0051928;GO:0061844;GO:0070098;GO:0070100;GO:0070233;GO:0070234;GO:0071346;GO:0071347;GO:0071356;GO:0090026;GO:0097696;GO:0098586;GO:0150078;GO:1904894;GO:2000110;GO:2000406;GO:2000503	phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435, IDA]; protein kinase activity [GO:0004672, IDA]; calcium ion transport [GO:0006816, IDA]; intracellular calcium ion homeostasis [GO:0006874, IDA]; exocytosis [GO:0006887, IDA]; leukocyte cell-cell adhesion [GO:0007159, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IDA]; cell-cell signaling [GO:0007267, IDA]; chemokine activity [GO:0008009, IDA]; response to toxic substance [GO:0009636, IDA]; positive regulation of macrophage chemotaxis [GO:0010759, IDA]; positive regulation of T cell chemotaxis [GO:0010820, IDA]; positive regulation of smooth muscle cell migration [GO:0014911, IDA]; phospholipase activator activity [GO:0016004, IDA]; membrane [GO:0016020, IDA]; receptor signaling protein tyrosine kinase activator activity [GO:0030298, IDA]; positive regulation of cell migration [GO:0030335, IDA]; phospholipase D-activating G protein-coupled receptor signaling pathway [GO:0031583, IDA]; CCR1 chemokine receptor binding [GO:0031726, IDA]; CCR1 chemokine receptor binding [GO:0031726, IPI]; CCR5 chemokine receptor binding [GO:0031730, IPI]; positive regulation of TOR signaling [GO:0032008, IDA]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634, IDA]; positive regulation of homotypic cell-cell adhesion [GO:0034112, IDA]; chemokine (C-C motif) ligand 5 signaling pathway [GO:0035689, IDA]; chemoattractant activity [GO:0042056, IDA]; positive regulation of T cell proliferation [GO:0042102, IDA]; neutrophil activation [GO:0042119, IDA]; chemokine receptor binding [GO:0042379, IDA]; chemokine receptor binding [GO:0042379, IPI]; identical protein binding [GO:0042802, IPI]; protein homodimerization activity [GO:0042803, IPI]; host-mediated suppression of viral transcription [GO:0043922, IDA]; cellular response to fibroblast growth factor stimulus [GO:0044344, IEP]; negative regulation of viral genome replication [GO:0045071, IDA]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744, IDA]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745, IDA]; positive regulation of cell adhesion [GO:0045785, IDA]; chemokine receptor antagonist activity [GO:0046817, IDA]; eosinophil chemotaxis [GO:0048245, IDA]; positive regulation of smooth muscle cell proliferation [GO:0048661, IDA]; regulation of insulin secretion [GO:0050796, IDA]; regulation of T cell activation [GO:0050863, IDA]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897, IDA]; positive regulation of calcium ion transport [GO:0051928, IDA]; chemokine-mediated signaling pathway [GO:0070098, IDA]; negative regulation of T cell apoptotic process [GO:0070233, IDA]; positive regulation of T cell apoptotic process [GO:0070234, IDA]; cellular response to type II interferon [GO:0071346, IEP]; cellular response to interleukin-1 [GO:0071347, IEP]; cellular response to tumor necrosis factor [GO:0071356, IEP]; positive regulation of monocyte chemotaxis [GO:0090026, IDA]; cellular response to virus [GO:0098586, IEP]; positive regulation of receptor signaling pathway via STAT [GO:1904894, IDA]; positive regulation of T cell migration [GO:2000406, IDA]; positive regulation of natural killer cell chemotaxis [GO:2000503, IDA]	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recom
P80098	CCL7	99	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1992-12-01	1	0	C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)	39	34	9	8	8	9	0	FP	1	1	1	GO:0002548;GO:0005576;GO:0006874;GO:0006935;GO:0006954;GO:0006955;GO:0007010;GO:0007165;GO:0007267;GO:0008009;GO:0008360;GO:0010332;GO:0030335;GO:0031726;GO:0031727;GO:0048020;GO:0048245;GO:0050729;GO:0061844;GO:0070098;GO:0071361;GO:2000503	cytoskeleton organization [GO:0007010, IDA]; chemokine activity [GO:0008009, IDA]; regulation of cell shape [GO:0008360, IDA]; positive regulation of cell migration [GO:0030335, IDA]; CCR1 chemokine receptor binding [GO:0031726, IPI]; eosinophil chemotaxis [GO:0048245, IDA]; positive regulation of inflammatory response [GO:0050729, IDA]; positive regulation of natural killer cell chemotaxis [GO:2000503, IDA]	Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to 
P80075	CCL8	99	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1992-12-01	1	0	C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]	28	27	9	8	6	4	0	FP	1	1	1	GO:0002687;GO:0004672;GO:0005576;GO:0006816;GO:0006874;GO:0006887;GO:0006935;GO:0006954;GO:0006955;GO:0007165;GO:0007267;GO:0008009;GO:0009615;GO:0016004;GO:0030335;GO:0031640;GO:0044828;GO:0048020;GO:0048245;GO:0061844;GO:0070098;GO:0070664	protein kinase activity [GO:0004672, IDA]; calcium ion transport [GO:0006816, IDA]; intracellular calcium ion homeostasis [GO:0006874, IDA]; exocytosis [GO:0006887, IDA]; cell-cell signaling [GO:0007267, IDA]; phospholipase activator activity [GO:0016004, IDA]; killing of cells of another organism [GO:0031640, IDA]; host-mediated suppression of viral genome replication [GO:0044828, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predom
P25063	CD24	80	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1992-05-01	1	0	Signal transducer CD24 (Small cell lung carcinoma cluster 4 antigen) (CD antigen CD24)	61	57	19	5	23	10	0	CFP	1	1	1	GO:0001666;GO:0001775;GO:0001959;GO:0002237;GO:0002768;GO:0005886;GO:0007155;GO:0007204;GO:0009897;GO:0009986;GO:0016020;GO:0016055;GO:0016477;GO:0019901;GO:0022407;GO:0030246;GO:0030296;GO:0030544;GO:0030856;GO:0031295;GO:0031514;GO:0031528;GO:0032597;GO:0032600;GO:0032715;GO:0032720;GO:0032913;GO:0042104;GO:0042632;GO:0043408;GO:0043627;GO:0045121;GO:0045730;GO:0051879;GO:0060170;GO:0071638;GO:0072112;GO:0072139;GO:0097193;GO:0098609;GO:0106015;GO:0106016;GO:2000768	response to hypoxia [GO:0001666, IEP]; cell activation [GO:0001775, IDA]; positive regulation of cytosolic calcium ion concentration [GO:0007204, IDA]; cell surface [GO:0009986, IDA]; membrane [GO:0016020, IDA]; protein kinase binding [GO:0019901, IPI]; protein tyrosine kinase activator activity [GO:0030296, IDA]; T cell costimulation [GO:0031295, IDA]; B cell receptor transport into membrane raft [GO:0032597, IDA]; negative regulation of transforming growth factor beta3 production [GO:0032913, IMP]; positive regulation of activated T cell proliferation [GO:0042104, IDA]; regulation of MAPK cascade [GO:0043408, IDA]; response to estrogen [GO:0043627, IEP]; membrane raft [GO:0045121, IDA]; respiratory burst [GO:0045730, IDA]; podocyte differentiation [GO:0072112, IMP]; glomerular parietal epithelial cell differentiation [GO:0072139, IMP]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768, IMP]	May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-d
P31358	CD52	61	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1993-07-01	1	0	CAMPATH-1 antigen (CDw52) (Cambridge pathology 1 antigen) (Epididymal secretory protein E5) (Human epididymis-specific protein 5) (He5) (CD antigen CD52)	11	9	1	2	1	5	0	P	0	1	1	GO:0005576;GO:0005886;GO:0007204;GO:0016020;GO:0045730;GO:0097225	positive regulation of cytosolic calcium ion concentration [GO:0007204, IDA]	May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Q6UWE3	CLPSL2	100	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2004-11-09	1	0	Colipase-like protein 2	9	8	0	1	7	0	0		1	1	1	GO:0001669;GO:0005576;GO:0007586;GO:0008047;GO:0016042;GO:0036126		
Q6PB30	CSAG1	78	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2007-06-26	1	0	Chondrosarcoma-associated gene 1 protein (Cancer/testis antigen 24.1) (CT24.1) (Cancer/testis antigen CSAGE)	5	5	3	0	2	0	0	CP	0	1	1	GO:0000922;GO:0005813;GO:0007098	spindle pole [GO:0000922, IDA]; centrosome [GO:0005813, IDA]; centrosome cycle [GO:0007098, IMP]	May play an important role in maintaining centrosome integrity during mitosis. {ECO:0000269|PubMed:32295846}.
P02778	CXCL10	98	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]	84	73	28	7	23	15	0	CFP	1	1	1	GO:0002690;GO:0005576;GO:0006935;GO:0006952;GO:0006954;GO:0006955;GO:0007166;GO:0007186;GO:0007189;GO:0007267;GO:0007517;GO:0008009;GO:0008015;GO:0008201;GO:0008284;GO:0008603;GO:0009897;GO:0010332;GO:0010818;GO:0010819;GO:0010996;GO:0016525;GO:0030335;GO:0030593;GO:0031640;GO:0032496;GO:0033280;GO:0034605;GO:0042056;GO:0042118;GO:0042127;GO:0042981;GO:0045236;GO:0045944;GO:0048248;GO:0050918;GO:0051281;GO:0061844;GO:0070098;GO:0071222;GO:0090026;GO:0097398;GO:0098586;GO:0140374;GO:1901509;GO:2000406	extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; chemotaxis [GO:0006935, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IMP]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189, IDA]; chemokine activity [GO:0008009, IDA]; heparin binding [GO:0008201, IMP]; T cell chemotaxis [GO:0010818, IMP]; regulation of T cell chemotaxis [GO:0010819, IDA]; negative regulation of angiogenesis [GO:0016525, IDA]; killing of cells of another organism [GO:0031640, IDA]; chemoattractant activity [GO:0042056, IDA]; endothelial cell activation [GO:0042118, IGI]; regulation of cell population proliferation [GO:0042127, IDA]; regulation of apoptotic process [GO:0042981, IDA]; CXCR3 chemokine receptor binding [GO:0048248, IDA]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; chemokine-mediated signaling pathway [GO:0070098, IMP]; cellular response to lipopolysaccharide [GO:0071222, IMP]; positive regulation of monocyte chemotaxis [GO:0090026, IDA]; cellular response to virus [GO:0098586, IEP]; antiviral innate immune response [GO:0140374, IEP]; regulation of endothelial tube morphogenesis [GO:1901509, IDA]; positive regulation of T cell migration [GO:2000406, IDA]	Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:11157474, PubMed:22652417, PubMed:7540647). Plays thereby an im
O14625	CXCL11	94	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2000-05-30	1	0	C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)	44	32	14	0	9	9	0	CFP	1	1	1	GO:0005576;GO:0006935;GO:0006952;GO:0006954;GO:0006955;GO:0007165;GO:0007189;GO:0007267;GO:0008009;GO:0008201;GO:0010818;GO:0016020;GO:0031640;GO:0042127;GO:0045236;GO:0048248;GO:0051281;GO:0061844;GO:0070098	chemotaxis [GO:0006935, IDA]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189, IDA]; chemokine activity [GO:0008009, IDA]; heparin binding [GO:0008201, IMP]; T cell chemotaxis [GO:0010818, IMP]; membrane [GO:0016020, IDA]; killing of cells of another organism [GO:0031640, IDA]; regulation of cell population proliferation [GO:0042127, IMP]; CXCR chemokine receptor binding [GO:0045236, IDA]; CXCR3 chemokine receptor binding [GO:0048248, IDA]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; chemokine-mediated signaling pathway [GO:0070098, IMP]	Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
P48061	CXCL12	93	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1996-02-01	1	0	Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]	110	90	33	8	29	20	0	CFP	1	1	1	GO:0001666;GO:0001764;GO:0001938;GO:0005102;GO:0005178;GO:0005576;GO:0006874;GO:0006935;GO:0006952;GO:0006955;GO:0007155;GO:0007165;GO:0007186;GO:0007411;GO:0008009;GO:0008015;GO:0008064;GO:0008284;GO:0008344;GO:0009612;GO:0009615;GO:0009897;GO:0010818;GO:0016020;GO:0022029;GO:0030335;GO:0031012;GO:0031100;GO:0031640;GO:0033603;GO:0033622;GO:0038146;GO:0038160;GO:0042379;GO:0043434;GO:0045236;GO:0045666;GO:0045785;GO:0048842;GO:0050921;GO:0050930;GO:0050965;GO:0050966;GO:0051924;GO:0060326;GO:0061844;GO:0070062;GO:0070098;GO:0090026;GO:0090280;GO:1902230;GO:1903237;GO:1904018;GO:1990478;GO:1990869;GO:2000406;GO:2000669	integrin binding [GO:0005178, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; chemokine activity [GO:0008009, IDA]; chemokine activity [GO:0008009, IMP]; T cell chemotaxis [GO:0010818, IDA]; membrane [GO:0016020, IDA]; extracellular matrix [GO:0031012, HDA]; killing of cells of another organism [GO:0031640, IDA]; integrin activation [GO:0033622, IDA]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146, IMP]; CXCL12-activated CXCR4 signaling pathway [GO:0038160, IDA]; CXCL12-activated CXCR4 signaling pathway [GO:0038160, IGI]; chemokine receptor binding [GO:0042379, IMP]; CXCR chemokine receptor binding [GO:0045236, IDA]; positive regulation of cell adhesion [GO:0045785, IDA]; cell chemotaxis [GO:0060326, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; extracellular exosome [GO:0070062, HDA]; chemokine-mediated signaling pathway [GO:0070098, IDA]; positive regulation of monocyte chemotaxis [GO:0090026, IDA]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230, IDA]; negative regulation of leukocyte tethering or rolling [GO:1903237, IDA]; positive regulation of vasculature development [GO:1904018, IMP]; cellular response to chemokine [GO:1990869, IMP]; positive regulation of T cell migration [GO:2000406, IDA]; negative regulation of dendritic cell apoptotic process [GO:2000669, IDA]	Chemoattractant active on T-lymphocytes and monocytes but not neutrophils (PubMed:18802065, PubMed:39093700). Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis (PubMed:8752281, PubMed:18802065, PubMed:39093700)
P10145	CXCL8	99	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1989-07-01	1	0	Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]	91	79	35	7	7	30	0	CFP	1	1	1	GO:0001525;GO:0002237;GO:0005153;GO:0005576;GO:0006935;GO:0006952;GO:0006954;GO:0006955;GO:0007165;GO:0007186;GO:0007204;GO:0008009;GO:0008201;GO:0008285;GO:0010628;GO:0010629;GO:0016020;GO:0019722;GO:0030155;GO:0030593;GO:0031623;GO:0031640;GO:0032642;GO:0034976;GO:0035556;GO:0042119;GO:0044344;GO:0045091;GO:0045236;GO:0045730;GO:0045744;GO:0045766;GO:0048566;GO:0050920;GO:0050930;GO:0060354;GO:0061844;GO:0071222;GO:0071347;GO:0071356;GO:0090023;GO:0097648;GO:2000535	response to molecule of bacterial origin [GO:0002237, IDA]; interleukin-8 receptor binding [GO:0005153, IPI]; chemokine activity [GO:0008009, IDA]; heparin binding [GO:0008201, IDA]; positive regulation of gene expression [GO:0010628, IDA]; negative regulation of gene expression [GO:0010629, IDA]; membrane [GO:0016020, IDA]; regulation of cell adhesion [GO:0030155, IDA]; neutrophil chemotaxis [GO:0030593, IDA]; neutrophil chemotaxis [GO:0030593, IGI]; receptor internalization [GO:0031623, IDA]; killing of cells of another organism [GO:0031640, IDA]; response to endoplasmic reticulum stress [GO:0034976, IDA]; intracellular signal transduction [GO:0035556, IDA]; neutrophil activation [GO:0042119, IDA]; cellular response to fibroblast growth factor stimulus [GO:0044344, IEP]; regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045091, IDA]; CXCR chemokine receptor binding [GO:0045236, IDA]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744, IDA]; positive regulation of angiogenesis [GO:0045766, IDA]; embryonic digestive tract development [GO:0048566, IEP]; induction of positive chemotaxis [GO:0050930, IGI]; negative regulation of cell adhesion molecule production [GO:0060354, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; cellular response to lipopolysaccharide [GO:0071222, IDA]; cellular response to interleukin-1 [GO:0071347, IEP]; cellular response to tumor necrosis factor [GO:0071356, IEP]; G protein-coupled receptor complex [GO:0097648, IPI]; regulation of entry of bacterium into host cell [GO:2000535, IMP]	Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activation (PubMed:2145175, PubMed:9623510). Released in respo
P59665	DEFA1; DEFA1B	94	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2003-04-30	1	0	Neutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]	64	62	30	8	4	20	0	CFP	1	1	1	GO:0002227;GO:0005576;GO:0005796;GO:0006935;GO:0006952;GO:0006955;GO:0010818;GO:0019731;GO:0030520;GO:0031640;GO:0035578;GO:0045087;GO:0050829;GO:0050830;GO:0051673;GO:0061844;GO:0070062;GO:0140911	innate immune response in mucosa [GO:0002227, IDA]; extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; T cell chemotaxis [GO:0010818, IDA]; antibacterial humoral response [GO:0019731, IDA]; estrogen receptor signaling pathway [GO:0030520, IDA]; killing of cells of another organism [GO:0031640, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]; extracellular exosome [GO:0070062, HDA]; pore-forming activity [GO:0140911, IDA]	Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072). In
P59666	DEFA3	94	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2003-04-30	1	0	Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]	41	41	17	8	4	12	0	CFP	1	1	1	GO:0002227;GO:0005576;GO:0005796;GO:0006952;GO:0019731;GO:0030520;GO:0031640;GO:0035578;GO:0042803;GO:0045087;GO:0050829;GO:0050830;GO:0051673;GO:0061844;GO:0070062;GO:0140911	innate immune response in mucosa [GO:0002227, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; antibacterial humoral response [GO:0019731, IDA]; estrogen receptor signaling pathway [GO:0030520, IDA]; killing of cells of another organism [GO:0031640, IDA]; protein homodimerization activity [GO:0042803, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; extracellular exosome [GO:0070062, HDA]	Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B.anthracis letha
P12838	DEFA4	97	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1989-10-01	1	0	Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4)	41	41	19	8	5	9	0	CFP	1	1	1	GO:0005576;GO:0005796;GO:0006952;GO:0010818;GO:0019730;GO:0019731;GO:0019732;GO:0030133;GO:0031640;GO:0035580;GO:0042582;GO:0042803;GO:0045087;GO:0050829;GO:0050830;GO:0050832;GO:0051673;GO:0061844;GO:0140911	T cell chemotaxis [GO:0010818, IDA]; antimicrobial humoral response [GO:0019730, IDA]; antibacterial humoral response [GO:0019731, IDA]; antifungal humoral response [GO:0019732, IDA]; killing of cells of another organism [GO:0031640, IDA]; azurophil granule [GO:0042582, IDA]; protein homodimerization activity [GO:0042803, IDA]; innate immune response [GO:0045087, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to fungus [GO:0050832, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (PubMed:15317502, PubMed:15616305, PubMed:2500436, PubMed:2501794, PubMed:30658057). Exhibits antimicrobial activity against Gram-negative E.coli 
Q01523	DEFA5	94	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1993-07-01	1	0	Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)]	61	59	35	8	5	11	0	CFP	1	1	1	GO:0005576;GO:0005796;GO:0006952;GO:0019731;GO:0030133;GO:0030141;GO:0031640;GO:0032757;GO:0034774;GO:0042803;GO:0045087;GO:0050829;GO:0050830;GO:0051289;GO:0051673;GO:0061844;GO:0140911;GO:1905710	extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; secretory granule [GO:0030141, IDA]; killing of cells of another organism [GO:0031640, IDA]; positive regulation of interleukin-8 production [GO:0032757, IDA]; protein homodimerization activity [GO:0042803, IDA]; innate immune response [GO:0045087, IMP]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-negative bacterium [GO:0050829, IMP]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to Gram-positive bacterium [GO:0050830, IMP]; protein homotetramerization [GO:0051289, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; positive regulation of membrane permeability [GO:1905710, IMP]	Host-defense peptide that maintains sterility in the urogenital system (PubMed:12021776, PubMed:12660734, PubMed:15616305, PubMed:19589339, PubMed:22359618, PubMed:22573326, PubMed:25354318, PubMed:25782105, PubMed:30808760). Has antimicrobial activity against a wide range of bacteria, including Gra
Q01524	DEFA6	100	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1993-07-01	1	0	Defensin-6 (Defensin, alpha 6)	29	24	6	8	5	5	0	CFP	1	1	1	GO:0005576;GO:0005796;GO:0006952;GO:0019731;GO:0030133;GO:0031640;GO:0042803;GO:0045087;GO:0050829;GO:0050830;GO:0051673;GO:0061844;GO:0140911	extracellular region [GO:0005576, EXP]; killing of cells of another organism [GO:0031640, IDA]; protein homodimerization activity [GO:0042803, IDA]	Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (PubMed:15616305, PubMed:17088326, PubMed:25158166, PubMed:25354318, PubMed:280269
P60022	DEFB1	68	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2003-11-21	1	0	Beta-defensin 1 (BD-1) (hBD-1) (Defensin, beta 1)	45	43	21	5	8	9	0	CFP	1	1	1	GO:0002227;GO:0005576;GO:0005796;GO:0006935;GO:0006952;GO:0006955;GO:0007186;GO:0009617;GO:0016020;GO:0019722;GO:0019731;GO:0031731;GO:0042742;GO:0042802;GO:0045087;GO:0050829;GO:0050830;GO:0060474;GO:0061844;GO:0070062;GO:0097225;GO:0140546;GO:1990742	innate immune response in mucosa [GO:0002227, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; response to bacterium [GO:0009617, IDA]; membrane [GO:0016020, IDA]; calcium-mediated signaling [GO:0019722, IDA]; antibacterial humoral response [GO:0019731, IDA]; CCR6 chemokine receptor binding [GO:0031731, IDA]; defense response to bacterium [GO:0042742, IMP]; identical protein binding [GO:0042802, IDA]; defense response to Gram-negative bacterium [GO:0050829, IMP]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to Gram-positive bacterium [GO:0050830, IMP]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]; extracellular exosome [GO:0070062, HDA]; sperm midpiece [GO:0097225, IDA]; microvesicle [GO:1990742, IDA]	Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). {ECO:0000269|
P81534	DEFB103A; DEFB103B	67	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2001-08-29	1	0	Beta-defensin 103 (Beta-defensin 3) (BD-3) (DEFB-3) (HBD3) (hBD-3) (Defensin, beta 103) (Defensin-like protein)	50	40	19	5	8	8	0	CP	1	1	1	GO:0005576;GO:0005796;GO:0006952;GO:0031640;GO:0031731;GO:0042056;GO:0042742;GO:0050829;GO:0050830;GO:0050918;GO:0060326;GO:0061844;GO:0140367;GO:0140546	extracellular region [GO:0005576, IDA]; killing of cells of another organism [GO:0031640, IDA]; defense response to bacterium [GO:0042742, IMP]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to Gram-positive bacterium [GO:0050830, IEP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; antibacterial innate immune response [GO:0140367, IDA]	Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {ECO:0000269|PubMed:11085
Q8WTQ1	DEFB104A; DEFB104B	72	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2002-05-27	1	0	Beta-defensin 104 (Beta-defensin 4) (BD-4) (DEFB-4) (hBD-4) (Defensin, beta 104)	11	11	8	0	3	0	0	FP	1	1	1	GO:0002548;GO:0005576;GO:0042056;GO:0045087;GO:0050829;GO:0050830;GO:0050918;GO:1904628	monocyte chemotaxis [GO:0002548, IDA]; chemoattractant activity [GO:0042056, IDA]; innate immune response [GO:0045087, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to Gram-positive bacterium [GO:0050830, IEP]; positive chemotaxis [GO:0050918, IDA]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628, IDA]	Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. {ECO:0000269|PubMed:11481241}.
Q8NG35	DEFB105A; DEFB105B	78	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2003-09-26	1	0	Beta-defensin 105 (Beta-defensin 5) (BD-5) (DEFB-5) (Defensin, beta 105)	3	3	0	0	3	0	0		0	1	1	GO:0005576;GO:0045087		Has antibacterial activity. {ECO:0000305}.
Q8N104	DEFB106A; DEFB106B	65	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2002-12-06	1	0	Beta-defensin 106 (Beta-defensin 6) (BD-6) (DEFB-6) (Defensin, beta 106)	15	14	10	0	4	0	0	CFP	1	1	1	GO:0001530;GO:0005576;GO:0005634;GO:0008201;GO:0016020;GO:0031727;GO:0045087;GO:0050829;GO:0050830;GO:0061760;GO:1990742	lipopolysaccharide binding [GO:0001530, IDA]; nucleus [GO:0005634, IDA]; heparin binding [GO:0008201, IDA]; membrane [GO:0016020, IDA]; CCR2 chemokine receptor binding [GO:0031727, IDA]; innate immune response [GO:0045087, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antifungal innate immune response [GO:0061760, IDA]; microvesicle [GO:1990742, IDA]	Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203). {ECO:0000269|PubMed:12600824, ECO:0000269|PubMed:23938203}.
Q8IZN7	DEFB107A; DEFB107B	70	secreted peptide / hormone / defensin	Evidence at transcript level	3.0	2003-09-26	1	0	Beta-defensin 107 (Beta-defensin 7) (BD-7) (DEFB-7) (Defensin, beta 107)	4	4	1	0	3	0	0	F	1	1	1	GO:0005576;GO:0008289;GO:0045087	lipid binding [GO:0008289, IMP]	Has antibacterial activity. {ECO:0000305}.
A8MXU0	DEFB108A; DEFB108C	73	secreted peptide / hormone / defensin	Uncertain	3.0	2008-06-10	1	0	Putative beta-defensin 108A (Defensin, beta 108A) (Defensin, beta 108C) (Putative beta-defensin 108B pseudogene 1/2)	5	5	0	0	5	0	0		0	1	1	GO:0005576;GO:0006952;GO:0045087;GO:0051707		Has antibacterial activity. {ECO:0000305}.
Q8NET1	DEFB108B	73	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2002-12-06	1	0	Beta-defensin 108B (Beta-defensin 8) (BD-8) (DEFB-8) (hBD-8) (Defensin, beta 108) (Defensin, beta 108B)	8	5	0	0	5	0	0		0	1	1	GO:0005576;GO:0006952;GO:0045087;GO:0051707		Has antibacterial activity. {ECO:0000250}.
Q30KR1	DEFB109B	87	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2005-12-20	1	0	Beta-defensin 109B (DEFB-109) (HBD9) (Defensin beta 109B)	9	9	0	5	4	0	0		1	1	1	GO:0005576;GO:0006952;GO:0031731;GO:0042056;GO:0042742;GO:0050918;GO:0051707;GO:0060326		Has antibacterial activity. {ECO:0000250}.
P0DY27	DEFB109C	87	secreted peptide / hormone / defensin	Inferred from homology	2.0	2025-04-09	1	0	Beta-defensin 109C	3	3	0	0	3	0	0		0	1	1	GO:0005576;GO:0006952;GO:0051707		Has antibacterial activity. {ECO:0000250}.
P0DY26	DEFB109D	87	secreted peptide / hormone / defensin	Inferred from homology	3.0	2025-04-09	1	0	Beta-defensin 109D	7	7	0	0	6	1	0		0	1	1	GO:0005576;GO:0005796;GO:0006952;GO:0051707		Has antibacterial activity. {ECO:0000250|UniProtKB:Q8N104}.
Q30KQ9	DEFB110	67	secreted peptide / hormone / defensin	Inferred from homology	4.0	2005-12-20	1	0	Beta-defensin 110 (Beta-defensin 10) (DEFB-10) (Beta-defensin 11) (DEFB-11) (Beta-defensin 111) (Defensin, beta 110) (Defensin, beta 111)	11	11	0	5	6	0	0		1	1	1	GO:0005576;GO:0006952;GO:0031731;GO:0042056;GO:0042742;GO:0045087;GO:0050918;GO:0051707;GO:0060326		Has antibacterial activity. {ECO:0000250}.
Q30KQ7	DEFB113	82	secreted peptide / hormone / defensin	Inferred from homology	2.0	2005-12-20	1	0	Beta-defensin 113 (Beta-defensin 13) (DEFB-13) (Defensin, beta 113)	3	3	0	0	3	0	0		0	1	1	GO:0005576;GO:0045087		Has antibacterial activity. {ECO:0000250}.
Q30KQ6	DEFB114	69	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2006-01-10	1	0	Beta-defensin 114 (Beta-defensin 14) (DEFB-14) (Defensin, beta 114)	20	20	9	5	6	0	0	FP	1	1	1	GO:0001530;GO:0005576;GO:0006952;GO:0031665;GO:0031731;GO:0032720;GO:0042056;GO:0042742;GO:0043407;GO:0045087;GO:0050729;GO:0050829;GO:0050830;GO:0050918;GO:0051707;GO:0060326;GO:0061760	lipopolysaccharide binding [GO:0001530, IDA]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665, IDA]; negative regulation of tumor necrosis factor production [GO:0032720, IMP]; negative regulation of MAP kinase activity [GO:0043407, IMP]; innate immune response [GO:0045087, IMP]; positive regulation of inflammatory response [GO:0050729, IMP]; defense response to Gram-negative bacterium [GO:0050829, IMP]; defense response to Gram-positive bacterium [GO:0050830, IMP]; antifungal innate immune response [GO:0061760, IMP]	Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LP
Q30KQ5	DEFB115	88	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2005-12-20	1	0	Beta-defensin 115 (Beta-defensin 15) (DEFB-15) (Defensin, beta 115)	9	7	0	3	4	0	0		1	1	1	GO:0005576;GO:0031640;GO:0045087;GO:0050829;GO:0140912		Has antibacterial activity. {ECO:0000250}.
Q8N690	DEFB119	84	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2002-12-06	1	0	Beta-defensin 119 (Beta-defensin 120) (Beta-defensin 19) (DEFB-19) (Beta-defensin 20) (DEFB-20) (Defensin, beta 119) (Defensin, beta 120) (ESC42-RELA)	8	8	5	0	3	0	0	FP	1	1	1	GO:0001530;GO:0005576;GO:0045087;GO:0050829;GO:0050830;GO:0061760	lipopolysaccharide binding [GO:0001530, IDA]; innate immune response [GO:0045087, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antifungal innate immune response [GO:0061760, IDA]	Has antibacterial activity. {ECO:0000305}.
Q5J5C9	DEFB121	76	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2005-03-15	1	0	Beta-defensin 121 (Beta-defensin 21) (DEFB-21) (Defensin, beta 121)	17	7	0	3	4	0	0		1	1	1	GO:0005576;GO:0031640;GO:0045087;GO:0050829;GO:0140912		Has antibacterial activity. {ECO:0000305}.
Q8N688	DEFB123	67	secreted peptide / hormone / defensin	Evidence at transcript level	3.0	2002-12-06	1	0	Beta-defensin 123 (Beta-defensin 23) (DEFB-23) (Defensin, beta 123)	7	7	0	3	4	0	0		1	1	1	GO:0005576;GO:0031640;GO:0045087;GO:0050829;GO:0140912		Has antibacterial activity. {ECO:0000305}.
Q8NES8	DEFB124	71	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2003-10-03	1	0	Beta-defensin 124 (Beta-defensin 24) (DEFB-24) (Defensin, beta 124)	14	12	9	0	3	0	0	P	0	1	1	GO:0005576;GO:0007249;GO:0032722;GO:0032735;GO:0032743;GO:0032755;GO:0045087;GO:0071224;GO:0071651;GO:0090026;GO:2000343	canonical NF-kappaB signal transduction [GO:0007249, IDA]; positive regulation of chemokine production [GO:0032722, IDA]; positive regulation of interleukin-12 production [GO:0032735, IDA]; positive regulation of interleukin-2 production [GO:0032743, IDA]; positive regulation of interleukin-6 production [GO:0032755, IDA]; cellular response to peptidoglycan [GO:0071224, IDA]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651, IDA]; positive regulation of monocyte chemotaxis [GO:0090026, IDA]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343, IDA]	Has antibacterial activity. {ECO:0000305}.
Q9H1M4	DEFB127	99	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2002-10-10	1	0	Beta-defensin 127 (Beta-defensin 27) (DEFB-27) (Defensin, beta 127)	20	8	2	0	4	2	0	P	0	1	1	GO:0005576;GO:0042742;GO:0045087;GO:0050829;GO:0061844	defense response to Gram-negative bacterium [GO:0050829, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	Has antibacterial activity. {ECO:0000305}.
Q7Z7B8	DEFB128	93	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2005-03-15	1	0	Beta-defensin 128 (Beta-defensin 28) (DEFB-28) (Defensin, beta 128)	12	11	7	0	4	0	0	P	0	1	1	GO:0005576;GO:0031640;GO:0045087;GO:0050829;GO:0050830	killing of cells of another organism [GO:0031640, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]	Has antibacterial activity. {ECO:0000305}.
P0DP74	DEFB130A	79	secreted peptide / hormone / defensin	Evidence at transcript level	3.0	2017-07-05	1	0	Beta-defensin 130A (Beta-defensin 130) (Beta-defensin 30) (DEFB-30) (Defensin, beta 130)	18	18	7	5	6	0	0	CP	1	1	1	GO:0005576;GO:0005829;GO:0006952;GO:0031731;GO:0042056;GO:0042742;GO:0042832;GO:0050918;GO:0051707;GO:0060326;GO:0061844	cytosol [GO:0005829, IDA]; defense response to protozoan [GO:0042832, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]	Antimicrobial host-defense peptide. Has an antiplasmodial activity. {ECO:0000269|PubMed:28181499}.
P0DP73	DEFB130B	79	secreted peptide / hormone / defensin	Evidence at transcript level	3.0	2017-07-05	1	0	Beta-defensin 130B	11	11	0	5	6	0	0		1	1	1	GO:0005576;GO:0006952;GO:0031731;GO:0042056;GO:0042742;GO:0050918;GO:0051707;GO:0060326		Antimicrobial host-defense peptide. Has an antiplasmodial activity. {ECO:0000269|PubMed:28181499}.
P59861	DEFB131A	70	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2003-09-26	1	0	Beta-defensin 131A (Beta-defensin 31) (DEFB-31) (Defensin, beta 131)	12	11	7	1	3	0	0	CP	0	1	1	GO:0002720;GO:0005576;GO:0032722;GO:0045087;GO:0061844;GO:0071223;GO:0090026	positive regulation of cytokine production involved in immune response [GO:0002720, IMP]; extracellular region [GO:0005576, IDA]; positive regulation of chemokine production [GO:0032722, IMP]; innate immune response [GO:0045087, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]; cellular response to lipoteichoic acid [GO:0071223, IMP]; positive regulation of monocyte chemotaxis [GO:0090026, IMP]	Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion (PubMed:26649771). {ECO:0000269|PubMed:26649771, ECO:0000305}.
A0A096LNP1	DEFB131B	70	secreted peptide / hormone / defensin	Inferred from homology	2.0	2017-08-30	1	0	Beta-defensin 131B (Defensin, beta 131)	4	4	0	1	3	0	0		0	1	1	GO:0005576;GO:0045087		Has antibacterial activity. {ECO:0000305}.
Q7Z7B7	DEFB132	95	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2005-03-15	1	0	Beta-defensin 132 (Beta-defensin 32) (BD-32) (DEFB-32) (Defensin HEL-75) (Defensin, beta 132)	9	8	3	0	4	1	0	CP	0	1	1	GO:0005576;GO:0031640;GO:0045087;GO:0050829;GO:0061827	extracellular region [GO:0005576, IDA]; killing of cells of another organism [GO:0031640, IDA]; sperm head [GO:0061827, IDA]	Has antibacterial activity. {ECO:0000305}.
Q30KQ1	DEFB133	61	secreted peptide / hormone / defensin	Inferred from homology	3.0	2005-12-20	1	0	Beta-defensin 133 (Defensin, beta 133)	11	11	0	5	6	0	0		1	1	1	GO:0005576;GO:0006952;GO:0031731;GO:0042056;GO:0042742;GO:0045087;GO:0050918;GO:0051707;GO:0060326		Has antibacterial activity. {ECO:0000305}.
Q4QY38	DEFB134	66	secreted peptide / hormone / defensin	Inferred from homology	2.0	2005-12-20	1	0	Beta-defensin 134 (Defensin, beta 134)	3	3	0	0	3	0	0		0	1	1	GO:0005576;GO:0045087		Has antibacterial activity. {ECO:0000305}.
Q30KP9	DEFB135	77	secreted peptide / hormone / defensin	Inferred from homology	3.0	2005-12-20	1	0	Beta-defensin 135 (Defensin, beta 135)	7	7	0	3	4	0	0		1	1	1	GO:0005576;GO:0031640;GO:0045087;GO:0050829;GO:0140912		Has antibacterial activity. {ECO:0000305}.
Q30KP8	DEFB136	78	secreted peptide / hormone / defensin	Inferred from homology	4.0	2005-12-20	1	0	Defensin beta 136 (Beta-defensin 136) (DEFB137)	11	11	5	3	2	1	0	FP	1	1	1	GO:0001530;GO:0005576;GO:0042742;GO:0050829;GO:0050830;GO:0061760;GO:0140367	lipopolysaccharide binding [GO:0001530, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antifungal innate immune response [GO:0061760, IDA]; antibacterial innate immune response [GO:0140367, IDA]	Host defense peptide that exhibits antibacterial and antifungal activity (PubMed:34481960). Exhibits antimicrobial activity against E.coli, S.aureus and C.albicans (in vitro) (PubMed:34481960). Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be involved in immunoregulation throug
O15263	DEFB4A; DEFB4B	64	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1998-07-15	1	0	Defensin beta 4A (Beta-defensin 2) (BD-2) (hBD-2) (Defensin, beta 2) (Skin-antimicrobial peptide 1) (SAP1)	49	45	25	5	8	7	0	CFP	1	1	1	GO:0005546;GO:0005576;GO:0005796;GO:0006935;GO:0006952;GO:0006955;GO:0007186;GO:0031640;GO:0031731;GO:0042056;GO:0042742;GO:0050829;GO:0050830;GO:0050832;GO:0050918;GO:0060326;GO:0061760;GO:0061844;GO:0140546	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546, IDA]; extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; chemotaxis [GO:0006935, IDA]; killing of cells of another organism [GO:0031640, IDA]; killing of cells of another organism [GO:0031640, IMP]; CCR6 chemokine receptor binding [GO:0031731, IDA]; defense response to bacterium [GO:0042742, IMP]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to fungus [GO:0050832, IDA]; antifungal innate immune response [GO:0061760, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]	Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria (PubMed:10837369, PubMed:9202117). Antimicrobial activity against P.aeruginosa seems to be salt-sensitive and is reduced with high salt concentrations great
Q6UWT2	ENHO	76	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2007-06-26	1	0	Adropin (Energy homeostasis-associated protein)	9	9	3	2	4	0	0	CFP	1	1	1	GO:0005179;GO:0005576;GO:0005886;GO:0007165;GO:0045747;GO:0097009	hormone activity [GO:0005179, IDA]; extracellular region [GO:0005576, IDA]; energy homeostasis [GO:0097009, IDA]	Involved in the regulation of glucose homeostasis and lipid metabolism. {ECO:0000250}.
Q8N5W8	FAM24B	94	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2005-02-15	1	0	Protein FAM24B	3	1	0	0	1	0	0		0	0	1	GO:0005576		
P30273	FCER1G	86	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1993-04-01	1	1	High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)	78	71	6	8	23	34	0	CFP	1	1	1	GO:0002283;GO:0002554;GO:0004888;GO:0005886;GO:0007166;GO:0007229;GO:0009897;GO:0009986;GO:0010543;GO:0016020;GO:0016064;GO:0019767;GO:0019863;GO:0019864;GO:0031623;GO:0032753;GO:0032998;GO:0033001;GO:0038094;GO:0038095;GO:0038156;GO:0042802;GO:0042803;GO:0045087;GO:0070821;GO:0071404;GO:0098797;GO:0101003	plasma membrane [GO:0005886, IDA]; cell surface [GO:0009986, IDA]; Fc-gamma receptor III complex [GO:0033001, IDA]; Fc-epsilon receptor signaling pathway [GO:0038095, IMP]; identical protein binding [GO:0042802, IDA]; protein homodimerization activity [GO:0042803, IDA]	Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive componen
Q8NFU4	FDCSP	85	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2002-11-28	1	0	Follicular dendritic cell secreted peptide (FDC secreted protein) (FDC-SP)	4	1	0	0	1	0	0		0	0	1	GO:0005576		Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
O00168	FXYD1	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1998-07-15	1	1	Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1)	47	47	0	2	15	30	0		1	1	1	GO:0005254;GO:0005886;GO:0005890;GO:0005901;GO:0006811;GO:0006821;GO:0006883;GO:0006936;GO:0008016;GO:0010248;GO:0010734;GO:0014704;GO:0016020;GO:0016324;GO:0017080;GO:0030007;GO:0030315;GO:0036376;GO:0042383;GO:0043269;GO:0044325;GO:0086036;GO:0099106;GO:1902305;GO:1902476;GO:1902600;GO:1903278;GO:1990573		Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 sub
Q14802	FXYD3	87	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1998-07-15	1	1	FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)	79	23	1	2	8	12	0	C	1	1	1	GO:0005254;GO:0005789;GO:0005886;GO:0005890;GO:0006821;GO:0006883;GO:0010248;GO:0016020;GO:0017080;GO:0030007;GO:0036376;GO:0043269;GO:0051117;GO:0070062;GO:0099106;GO:1902476;GO:1902600;GO:1903278;GO:1990573	extracellular exosome [GO:0070062, HDA]	Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (Pu
P59646	FXYD4	89	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2003-04-30	1	1	FXYD domain-containing ion transport regulator 4	23	23	1	2	7	13	0	C	1	1	1	GO:0005886;GO:0005890;GO:0006883;GO:0010248;GO:0016020;GO:0016323;GO:0017080;GO:0030007;GO:0036376;GO:0043269;GO:0051117;GO:0071805;GO:0099106;GO:1902600;GO:1903278;GO:1990573	sodium:potassium-exchanging ATPase complex [GO:0005890, IPI]	Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Increases the apparent affinity of the transporter for Na(+) and increases N
Q9H0Q3	FXYD6	95	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2002-01-23	1	1	FXYD domain-containing ion transport regulator 6 (Phosphohippolin)	67	17	1	2	5	9	0	C	1	1	1	GO:0005886;GO:0006883;GO:0010248;GO:0016020;GO:0017080;GO:0030007;GO:0036376;GO:0043269;GO:0099106;GO:1902600;GO:1903278;GO:1990573	plasma membrane [GO:0005886, IDA]	Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for intracellular Na(+) with no change in the apparent affinit
P58550	FXYD6P3	94	secreted peptide / hormone / defensin	Uncertain	2.0	2002-01-23	1	1	Putative FXYD domain-containing ion transport regulator 8	7	7	0	2	5	0	0		1	1	1	GO:0005886;GO:0016020;GO:0017080;GO:0043269;GO:0099106;GO:1903278		
Q8IVK1	GLYCAM1	47	secreted peptide / hormone / defensin	Uncertain	2.0	2008-07-01	1	0	Putative glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)	1	1	0	0	0	1	0		0	0	1	GO:0005886		
P01148	GNRH1	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Progonadoliberin-1 (Progonadoliberin I) [Cleaved into: Gonadoliberin-1 (Gonadoliberin I) (Gonadorelin) (Gonadotropin-releasing hormone I) (GnRH-I) (Luliberin I) (Luteinizing hormone-releasing hormone I) (LH-RH I); GnRH-associated peptide 1 (GnRH-associated peptide I)]	39	39	0	4	25	10	0		1	1	1	GO:0005179;GO:0005183;GO:0005576;GO:0005798;GO:0007165;GO:0007267;GO:0007565;GO:0023051;GO:0030238;GO:0030425;GO:0031530;GO:0032496;GO:0033087;GO:0033574;GO:0034695;GO:0035864;GO:0042698;GO:0043066;GO:0043204;GO:0043434;GO:0043679;GO:0044849;GO:0098556;GO:1990008;GO:1990637		Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Q6UWK7	GPR15LG	81	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2006-11-28	1	0	Protein GPR15LG (Antimicrobial peptide with 57 amino acid residues) (AP-57) (Antimicrobial peptide-57) (Colon-derived SUSD2 binding factor) (CSBF) (Protein GPR15 ligand) (Protein GPR15L) (Secreted protein C10orf99)	27	24	19	0	5	0	0	CFP	1	1	1	GO:0001664;GO:0005576;GO:0007186;GO:0008009;GO:0010837;GO:0043029;GO:0043303;GO:0048018;GO:0048247;GO:0050830;GO:0050832;GO:0051782;GO:0072678;GO:1902807;GO:2000404	G protein-coupled receptor binding [GO:0001664, IDA]; extracellular region [GO:0005576, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IDA]; chemokine activity [GO:0008009, IDA]; regulation of keratinocyte proliferation [GO:0010837, IMP]; T cell homeostasis [GO:0043029, IDA]; mast cell degranulation [GO:0043303, IMP]; receptor ligand activity [GO:0048018, IDA]; lymphocyte chemotaxis [GO:0048247, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to fungus [GO:0050832, IDA]; negative regulation of cell division [GO:0051782, IDA]; T cell migration [GO:0072678, IDA]; negative regulation of cell cycle G1/S phase transition [GO:1902807, IDA]; regulation of T cell migration [GO:2000404, IDA]	Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth 
P06028	GYPB	91	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1987-08-13	1	1	Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)	15	9	1	1	3	4	0	C	0	0	1	GO:0005886;GO:0016020;GO:0170014	ankyrin-1 complex [GO:0170014, IDA]	Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. {ECO:0000269|PubMed:35835865}.
P15421	GYPE	78	secreted peptide / hormone / defensin	Evidence at protein level	3.0	1990-04-01	1	1	Glycophorin-E	5	5	0	1	2	2	0		0	0	1	GO:0005886;GO:0016020		This protein is a minor sialoglycoprotein in human erythrocyte membranes.
P81172	HAMP	84	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1998-12-15	1	0	Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)]	65	65	51	4	7	3	0	CFP	1	1	1	GO:0000122;GO:0002092;GO:0005102;GO:0005179;GO:0005576;GO:0006879;GO:0006955;GO:0007165;GO:0010039;GO:0031640;GO:0032436;GO:0034760;GO:0042742;GO:0050829;GO:0050830;GO:0050832;GO:0055080;GO:0060586;GO:0061844;GO:0097690;GO:0098771;GO:0141108;GO:1902916;GO:1904039;GO:1904479;GO:2000646	positive regulation of receptor internalization [GO:0002092, IDA]; signaling receptor binding [GO:0005102, IPI]; hormone activity [GO:0005179, IDA]; extracellular region [GO:0005576, IDA]; intracellular iron ion homeostasis [GO:0006879, IDA]; response to iron ion [GO:0010039, IMP]; killing of cells of another organism [GO:0031640, IDA]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; defense response to fungus [GO:0050832, IDA]; multicellular organismal-level iron ion homeostasis [GO:0060586, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; iron ion transmembrane transporter inhibitor activity [GO:0097690, IDA]; transporter regulator activity [GO:0141108, IDA]; positive regulation of protein polyubiquitination [GO:1902916, IDA]; negative regulation of iron export across plasma membrane [GO:1904039, IDA]; negative regulation of intestinal absorption [GO:1904479, IMP]; positive regulation of receptor catabolic process [GO:2000646, IDA]	Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:226
Q9UBK5	HCST	93	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2008-04-29	1	1	Hematopoietic cell signal transducer (DNAX-activation protein 10) (Membrane protein DAP10) (Transmembrane adapter protein KAP10)	27	21	11	3	6	1	0	CFP	1	1	1	GO:0005102;GO:0005886;GO:0006468;GO:0009986;GO:0016020;GO:0030674;GO:0042267;GO:0043548;GO:0050776;GO:0051897	signaling receptor binding [GO:0005102, IPI]; plasma membrane [GO:0005886, IDA]; protein phosphorylation [GO:0006468, IGI]; cell surface [GO:0009986, IDA]; protein-macromolecule adaptor activity [GO:0030674, IDA]; natural killer cell mediated cytotoxicity [GO:0042267, IDA]; phosphatidylinositol 3-kinase binding [GO:0043548, IDA]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897, IDA]	Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL1
Q9Y5L2	HILPDA	63	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2000-05-30	0	1	Hypoxia-inducible lipid droplet-associated protein (Hypoxia-inducible gene 2 protein)	25	23	11	2	7	3	0	CFP	1	1	1	GO:0001819;GO:0005102;GO:0005576;GO:0005811;GO:0005829;GO:0008284;GO:0009986;GO:0010884;GO:0016020;GO:0030141;GO:0034389;GO:0035425;GO:0071456;GO:0120009;GO:0120013	positive regulation of cytokine production [GO:0001819, IDA]; signaling receptor binding [GO:0005102, IPI]; extracellular region [GO:0005576, IDA]; lipid droplet [GO:0005811, IDA]; positive regulation of cell population proliferation [GO:0008284, IDA]; cell surface [GO:0009986, IDA]; positive regulation of lipid storage [GO:0010884, IDA]; secretory granule [GO:0030141, IDA]; autocrine signaling [GO:0035425, IDA]; cellular response to hypoxia [GO:0071456, IEP]	Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. {ECO:0000269|PubMed:15930302, ECO:0000269|PubMed:20624928}.
P15515	HTN1	57	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1990-04-01	1	0	Histatin-1 (Hst1) (Histidine-rich protein 1) (Post-PB protein) (PPB) [Cleaved into: His1-(31-57)-peptide (His1 31/57) (His1-(12-38)-peptide) (His1 12/38) (Histatin 2) (Hst2) (Histatin-2)]	42	40	26	4	5	5	0	CP	0	1	1	GO:0005576;GO:0005739;GO:0005783;GO:0005789;GO:0009893;GO:0022409;GO:0031640;GO:0035470;GO:0042742;GO:0061844;GO:0090303;GO:1900026;GO:1903691	extracellular region [GO:0005576, IDA]; mitochondrion [GO:0005739, IDA]; mitochondrion [GO:0005739, IMP]; endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum [GO:0005783, IMP]; endoplasmic reticulum membrane [GO:0005789, EXP]; positive regulation of metabolic process [GO:0009893, IDA]; positive regulation of metabolic process [GO:0009893, IMP]; positive regulation of cell-cell adhesion [GO:0022409, IDA]; killing of cells of another organism [GO:0031640, IDA]; positive regulation of vascular wound healing [GO:0035470, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; positive regulation of wound healing [GO:0090303, IDA]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026, IDA]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691, IDA]	Histatins (Hsts) are cationic and histidine-rich secreted peptides mainly synthesized by saliva glands of humans and higher primates (PubMed:3286634, PubMed:3944083). Hsts are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be
P15516	HTN3	51	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1990-04-01	1	0	Histatin-3 (Basic histidine-rich protein) (Hst) (Histatin 3) (Hst 3) (Histidine-rich protein 3) (PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide (His3 20/44) (His3-(1-25)-peptide) (His3 1/25) (Histatin 6) (Histatin-3 1/25) (Histatin-6); His3-(20-43)-peptide (His3 20/43) (His3-(1-24)-peptide) (His3 1/24) (Histatin 5) (Hst 5) (Histatin-3 1/24) (Histatin-5); His3-(20-32)-peptide (His3 20/32) (His3-(1-13)-peptide) (His3 1/13) (Histatin-3 1/13); His3-(20-31)-peptide (His3 20/31) (His3-(1-12)-peptide) (His3 1/12) (Histatin-3 1/12); His3-(20-30)-peptide (His3 20/30) (His3-(1-11)-peptide) (His3 1/11) (Histatin-3 1/11); His3-(24-32)-peptide (His3 24/32) (His3-(5-13)-peptide) (His3 5/13) (Histatin-3 5/13); His3-(24-31)-peptide (His3 24/31) (His3-(5-12)-peptide) (His3 5/12) (Histatin 11) (Histatin-11) (Histatin-3 5/12); His3-(24-30)-peptide (His3 24/30) (His3-(5-11)-peptide) (His3 5/11) (Histatin 12) (Histatin-12) (Histatin-3 5/11); His3-(25-32)-peptide (His3 25/32) (His3-(6-13)-peptide) (His3 6/13) (Histatin-3 6/13); His3-(25-30)-peptide (His3 25/30) (His3-(6-11)-peptide) (His3 6/11) (Histatin-3 6/11); His3-(26-32)-peptide (His3 26/32) (His3-(7-13)-peptide) (His3 7/13) (Histatin-3 7/13); His3-(26-31)-peptide (His3 26/31) (His3-(7-12)-peptide) (His3 7/12) (Histatin-3 7/12); His3-(26-30)-peptide (His3 26/30) (His3-(7-11)-peptide) (His3 7/11) (Histatin-3 7/11); His3-(31-51)-peptide (His3 31/51) (His3-(12-32)-peptide) (His3 12/32) (Histatin 4) (Histatin-3 12/32) (Histatin-4); His3-(31-44)-peptide (His3 31/44) (His3-(12-25)-peptide) (His3 12/25) (Histatin 9) (Histatin-3 12/25) (Histatin-9); His3-(31-43)-peptide (His3 31/43) (His3-(12-24)-peptide) (His3 12/24) (Histatin 7) (Histatin-3 12/24) (Histatin-7); His3-(32-44)-peptide (His3 32/44) (His3-(13-25)-peptide) (His3 13/25) (Histatin 10) (Histatin-10) (Histatin-3 13/25); His3-(32-43)-peptide (His3 32-43) (His3-(13-24)-peptide) (His3 13/24) (Histatin 8) (Histatin-3 13/24) (Histatin-8); His3-(33-44)-peptide (His3 33/44) (His3-(14-25)-peptide) (His3 14/25) (Histatin-3 14/25); His3-(33-43)-peptide (His3 33/43) (His3-(14-24)-peptide) (His3 14/24) (Histatin-3 14/24); His3-(34-44)-peptide (His3 34/44) (His3-(15-25)-peptide) (His3 15/25) (Histatin-3 15/25); His3-(34-43)-peptide (His3 34/43) (His3-(15-24)-peptide) (His3 15/24) (Histatin-3 15/24); His3-(45-51)-peptide (His3 45/51) (His3-(26-32)-peptide) (His3 26/32) (Histatin-3 26/32); His3-(47-51)-peptide (His3 47/51) (His3-(28-32)-peptide) (His3 28/32) (Histatin-3 28/32); His3-(48-51)-peptide (His3 48/51) (His3-(29-32)-peptide) (His3 29/32) (Histatin-3 29/32)]	50	47	33	4	4	6	0	CFP	1	1	1	GO:0005576;GO:0005739;GO:0031640;GO:0042742;GO:0042803;GO:0048146;GO:0050832;GO:0060090;GO:0061844;GO:0090303	extracellular region [GO:0005576, EXP]; extracellular region [GO:0005576, IDA]; mitochondrion [GO:0005739, EXP]; mitochondrion [GO:0005739, IDA]; killing of cells of another organism [GO:0031640, IDA]; killing of cells of another organism [GO:0031640, IMP]; defense response to bacterium [GO:0042742, IDA]; protein homodimerization activity [GO:0042803, IDA]; positive regulation of fibroblast proliferation [GO:0048146, IMP]; defense response to fungus [GO:0050832, IDA]; defense response to fungus [GO:0050832, IMP]; molecular adaptor activity [GO:0060090, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; positive regulation of wound healing [GO:0090303, IDA]	Histatins are cationic and histidine-rich peptides mainly found in the saliva of higher primates (PubMed:3286634). They are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their bi
P10997	IAPP	89	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1989-07-01	1	0	Islet amyloid polypeptide (IAPP) (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide)	64	60	29	1	11	19	0	CFP	1	1	1	GO:0001540;GO:0005102;GO:0005179;GO:0005576;GO:0006915;GO:0007165;GO:0007189;GO:0007267;GO:0008285;GO:0008289;GO:0010628;GO:0016234;GO:0031333;GO:0031648;GO:0042755;GO:0042802;GO:0043025;GO:0043065;GO:0043410;GO:0048018;GO:0050850;GO:0051260;GO:0051897;GO:0070374;GO:0097646;GO:0097647;GO:0141163;GO:0150059;GO:0150060;GO:0150061;GO:1905907;GO:1990000	signaling receptor binding [GO:0005102, IPI]; extracellular region [GO:0005576, IDA]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189, IGI]; negative regulation of cell population proliferation [GO:0008285, IDA]; lipid binding [GO:0008289, EXP]; positive regulation of gene expression [GO:0010628, IGI]; inclusion body [GO:0016234, IDA]; protein destabilization [GO:0031648, IDA]; identical protein binding [GO:0042802, IDA]; identical protein binding [GO:0042802, IPI]; receptor ligand activity [GO:0048018, IDA]; positive regulation of calcium-mediated signaling [GO:0050850, IGI]; protein homooligomerization [GO:0051260, IDA]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897, IGI]; positive regulation of ERK1 and ERK2 cascade [GO:0070374, IGI]; amylin receptor signaling pathway [GO:0097647, IDA]; amylin receptor signaling pathway [GO:0097647, IGI]; positive regulation of cAMP/PKA signal transduction [GO:0141163, IGI]; amylin receptor 1 signaling pathway [GO:0150059, IDA]; amylin receptor 2 signaling pathway [GO:0150060, IDA]; amylin receptor 3 signaling pathway [GO:0150061, IDA]; amyloid fibril formation [GO:1990000, IDA]	Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is me
A6NJ69	IGIP	53	secreted peptide / hormone / defensin	Inferred from homology	2.0	2008-04-29	1	0	IgA-inducing protein homolog	1	1	0	0	1	0	0		0	0	1	GO:0005576		Enhances IgA secretion from B-cells stimulated via CD40. {ECO:0000250}.
A0A1W2PQU2	KANTR	76	secreted peptide / hormone / defensin	Inferred from homology	2.0	2023-06-28	1	1	KANTR integral membrane protein	1	1	0	0	1	0	0		0	0	1	GO:0016020		
P60985	KRTDAP	99	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2004-04-26	1	0	Keratinocyte differentiation-associated protein	7	7	2	2	3	0	0	C	0	1	1	GO:0005576;GO:0008544;GO:0042599	extracellular region [GO:0005576, IDA]; lamellar body [GO:0042599, IDA]	May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. {ECO:0000269|PubMed:15140226}.
Q969E1	LEAP2	77	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2002-03-05	1	0	Liver-expressed antimicrobial peptide 2 (LEAP-2)	5	5	2	0	2	1	0	P	0	1	1	GO:0005576;GO:0042742;GO:0050832;GO:0061844	defense response to fungus [GO:0050832, IMP]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IMP]	Has an antimicrobial activity. {ECO:0000269|PubMed:20845358}.
Q96DR8	MUCL1	90	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2006-03-21	1	0	Mucin-like protein 1 (Protein BS106) (Small breast epithelial mucin)	23	22	0	0	2	20	0		0	0	1	GO:0005576;GO:0005796;GO:0005886;GO:0016020		May play a role as marker for the diagnosis of metastatic breast cancer. {ECO:0000269|PubMed:12019145, ECO:0000269|PubMed:12595743, ECO:0000269|PubMed:15684711}.
Q8IVN3	MUSTN1	82	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2007-09-11	0	0	Musculoskeletal embryonic nuclear protein 1	19	19	0	0	14	5	0		0	1	1	GO:0002062;GO:0005576;GO:0005634;GO:0005654;GO:0005737;GO:0030326;GO:0035988;GO:0042246;GO:0042593;GO:0045663		Required for chondrocyte development and proliferation. Plays a role in myoblast differentiation and fusion. Modulates skeletal muscle extracellular matrix composition. Plays a role in skeletal muscle function. Plays a role in glucose homeostasis. {ECO:0000250|UniProtKB:Q99JI1}.
Q5BLP8	NICOL1	95	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2008-07-01	1	0	NELL2-interacting cell ontogeny regulator 1 (NELL2-interacting cofactor for lumicrine signaling) (NICOL)	9	9	0	2	2	5	0		1	1	1	GO:0003730;GO:0005576;GO:0007283;GO:0048471;GO:0070935		mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRN
P0C0P6	NPS	89	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2005-11-22	1	0	Neuropeptide S	23	23	6	3	5	9	0	FP	1	1	1	GO:0005576;GO:0007200;GO:0007218;GO:0010841;GO:0032230;GO:0045760;GO:0051968;GO:0070374;GO:0141163;GO:0160041	phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200, IDA]; positive regulation of ERK1 and ERK2 cascade [GO:0070374, IDA]; positive regulation of cAMP/PKA signal transduction [GO:0141163, IDA]; neuropeptide activity [GO:0160041, IDA]	Ligand for NPSR1 (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440). Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracell
P01303	NPY	97	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]	80	78	19	5	34	20	0	CFP	1	1	1	GO:0001664;GO:0001878;GO:0002865;GO:0004930;GO:0005102;GO:0005179;GO:0005184;GO:0005246;GO:0005576;GO:0005737;GO:0005794;GO:0007186;GO:0007187;GO:0007193;GO:0007204;GO:0007218;GO:0007268;GO:0007631;GO:0008284;GO:0008343;GO:0010811;GO:0019731;GO:0019732;GO:0021954;GO:0021987;GO:0031175;GO:0031841;GO:0032100;GO:0032903;GO:0042117;GO:0042756;GO:0043195;GO:0043204;GO:0045087;GO:0045428;GO:0045776;GO:0045964;GO:0048471;GO:0048572;GO:0048589;GO:0050829;GO:0050830;GO:0060575;GO:0061844;GO:0070374;GO:0098982;GO:0098992;GO:0099509;GO:0099538;GO:0160041;GO:1904000;GO:2000300	response to yeast [GO:0001878, IDA]; extracellular region [GO:0005576, IDA]; Golgi apparatus [GO:0005794, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IDA]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193, IDA]; positive regulation of cytosolic calcium ion concentration [GO:0007204, IDA]; antibacterial humoral response [GO:0019731, IDA]; antifungal humoral response [GO:0019732, IDA]; central nervous system neuron development [GO:0021954, IEP]; cerebral cortex development [GO:0021987, IEP]; neuron projection development [GO:0031175, IEP]; innate immune response [GO:0045087, IDA]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-positive bacterium [GO:0050830, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]; neuropeptide activity [GO:0160041, IDA]	[Neuropeptide Y]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1321422, PubMed:7592910, PubMed:35165283, PubMed:35507650, PubMed:36525977, PubMed:38882210). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signal
Q8NHW6	OTOS	89	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2004-12-07	1	0	Otospiralin	6	3	0	1	2	0	0		0	1	1	GO:0005576;GO:0007605		May be essential for the survival of the neurosensory epithelium of the inner ear. {ECO:0000250}.
B3GLJ2	PATE3	98	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2008-11-25	1	0	Prostate and testis expressed protein 3 (Acrosomal vesicle protein HEL-127) (PATE-like protein DJ) (PATE-DJ)	1	1	0	0	1	0	0		0	0	1	GO:0005576		
P0C8F1	PATE4	98	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2008-11-25	1	0	Prostate and testis expressed protein 4 (PATE-like protein B) (PATE-B)	7	7	5	0	2	0	0	CFP	1	1	1	GO:0001669;GO:0005576;GO:0030548;GO:0099601	acrosomal vesicle [GO:0001669, IDA]; extracellular region [GO:0005576, IDA]; acetylcholine receptor regulator activity [GO:0030548, IDA]; regulation of neurotransmitter receptor activity [GO:0099601, IDA]	May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility. {ECO:0000269|PubMed:18387948}.
Q5JTB6	PLAC9	97	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2006-11-28	1	0	Placenta-specific protein 9	5	1	0	0	1	0	0		0	0	1	GO:0005576		
Q15195	PLGLA	96	secreted peptide / hormone / defensin	Evidence at transcript level	2.0	2007-10-02	1	0	Plasminogen-like protein A (Plasminogen-like protein A1) (Plasminogen-related protein A)	1	1	0	0	1	0	0		0	0	1	GO:0005576		May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity)
Q02325	PLGLB1; PLGLB2	96	secreted peptide / hormone / defensin	Evidence at protein level	3.0	1994-06-01	1	0	Plasminogen-like protein B (Plasminogen-related protein B)	1	1	0	0	1	0	0		0	0	1	GO:0005576		May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.
P01298	PPY	95	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)]	23	22	5	5	6	6	0	CF	1	1	1	GO:0001664;GO:0005179;GO:0005184;GO:0005576;GO:0005737;GO:0007218;GO:0007631;GO:0009306;GO:0031841	G protein-coupled receptor binding [GO:0001664, IPI]; extracellular region [GO:0005576, EXP]	[Pancreatic polypeptide]: Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2. {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}.
P81277	PRLH	87	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2000-05-30	1	0	Prolactin-releasing peptide (PrRP) (Prolactin-releasing hormone) [Cleaved into: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]	14	14	0	5	7	2	0		1	1	1	GO:0005179;GO:0005184;GO:0005576;GO:0005737;GO:0007186;GO:0007631;GO:0031861;GO:0043434		Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.
Q86SH4	PRNT	94	secreted peptide / hormone / defensin	Uncertain	2.0	2008-02-26	1	0	Putative testis-specific prion protein (Protein M8)	1	1	0	0	1	0	0		0	0	1	GO:0005576		
Q96A98	PTH2	100	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2006-02-07	1	0	Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2)	9	7	0	0	3	4	0		0	1	1	GO:0005576;GO:0007218		Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activati
P10082	PYY	97	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1989-07-01	1	0	Peptide YY (PYY) (PYY-I) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3-36) (PYY-II)]	28	26	10	5	3	8	0	CFP	1	1	1	GO:0001664;GO:0002791;GO:0005179;GO:0005184;GO:0005576;GO:0007186;GO:0007218;GO:0007631;GO:0031841;GO:0048018;GO:0060575;GO:1903999	G protein-coupled receptor binding [GO:0001664, IPI]; neuropeptide hormone activity [GO:0005184, IDA]; extracellular region [GO:0005576, IDA]; G protein-coupled receptor signaling pathway [GO:0007186, IDA]; receptor ligand activity [GO:0048018, IDA]; negative regulation of eating behavior [GO:1903999, IDA]	[Peptide YY]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1317848, PubMed:7592910, PubMed:36525977). Also binds NPY5R (By similarity). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inh
Q9NRI6	PYY2	33	secreted peptide / hormone / defensin	Uncertain	2.0	2008-09-02	1	0	Putative peptide YY-2 (Putative peptide YY2)	1	1	0	0	1	0	0		0	0	1	GO:0005576		
Q5JQD4	PYY3	70	secreted peptide / hormone / defensin	Uncertain	2.0	2008-06-10	1	0	Putative peptide YY-3 (Putative peptide YY3) (PYY-III)	8	8	0	5	3	0	0		1	1	1	GO:0005179;GO:0005184;GO:0005576;GO:0007218;GO:0007631;GO:0031841		
Q6UY13		95	secreted peptide / hormone / defensin	Inferred from homology	2.0	2008-02-05	1	0	Putative uncharacterized protein UNQ5830/PRO19650/PRO19816	7	7	0	6	1	0	0		1	1	1	GO:0005125;GO:0005576;GO:0007166;GO:0043123;GO:0045672;GO:2001238		
Q8TAT8		98	secreted peptide / hormone / defensin	Uncertain	2.0	2008-09-02	1	0	Putative uncharacterized protein LOC644613	0	0	0	0	0	0	0		0	0	0			
Q9P1C3		46	secreted peptide / hormone / defensin	Uncertain	1.0	2008-06-10	1	0	Putative uncharacterized protein PRO2829	1	1	0	0	1	0	0		0	0	1	GO:0005576		
A6NC62	RBAKDN	81	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2008-02-26	1	0	RBAK downstream neighbor protein	1	1	0	0	1	0	0		0	0	1	GO:0005576		
P60602	ROMO1	79	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2004-03-15	0	1	Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog)	32	30	23	3	1	3	0	CFP	1	1	1	GO:0005739;GO:0005743;GO:0005744;GO:0006886;GO:0008324;GO:0030150;GO:0034614;GO:0042742;GO:0045039;GO:0050829;GO:0050830;GO:0090399;GO:0098655;GO:0140367;GO:2000379	mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, IDA]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744, IDA]; monoatomic cation transmembrane transporter activity [GO:0008324, IDA]; cellular response to reactive oxygen species [GO:0034614, IMP]; defense response to bacterium [GO:0042742, IDA]; protein insertion into mitochondrial inner membrane [GO:0045039, IMP]; defense response to Gram-negative bacterium [GO:0050829, IDA]; defense response to Gram-negative bacterium [GO:0050829, IMP]; defense response to Gram-positive bacterium [GO:0050830, IDA]; replicative senescence [GO:0090399, IMP]; monoatomic cation transmembrane transport [GO:0098655, IDA]; antibacterial innate immune response [GO:0140367, IDA]; antibacterial innate immune response [GO:0140367, IMP]; positive regulation of reactive oxygen species metabolic process [GO:2000379, IDA]	Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.; Has antibacterial activity against a v
P80511	S100A12	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1996-10-01	0	0	Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]	50	47	10	7	6	24	0	CFP	1	1	1	GO:0002548;GO:0005507;GO:0005509;GO:0005576;GO:0005634;GO:0005737;GO:0005829;GO:0005856;GO:0005886;GO:0006805;GO:0006954;GO:0008270;GO:0030593;GO:0031640;GO:0034774;GO:0042742;GO:0042802;GO:0043123;GO:0043406;GO:0043542;GO:0045087;GO:0045576;GO:0048306;GO:0050729;GO:0050786;GO:0050832;GO:0061844	nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; xenobiotic metabolic process [GO:0006805, IDA]; killing of cells of another organism [GO:0031640, IDA]; identical protein binding [GO:0042802, IPI]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, IDA]; RAGE receptor binding [GO:0050786, IDA]; RAGE receptor binding [GO:0050786, IPI]; defense response to fungus [GO:0050832, IDA]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844, IDA]	S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion
Q99584	S100A13	98	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1997-11-01	0	0	Protein S100-A13 (S100 calcium-binding protein A13)	34	29	20	6	2	1	0	CFP	1	1	1	GO:0001819;GO:0005507;GO:0005509;GO:0005576;GO:0005634;GO:0005737;GO:0005829;GO:0008270;GO:0017134;GO:0032730;GO:0042803;GO:0043123;GO:0043303;GO:0048306;GO:0048471;GO:0050786	positive regulation of cytokine production [GO:0001819, IMP]; copper ion binding [GO:0005507, IDA]; calcium ion binding [GO:0005509, IDA]; extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; zinc ion binding [GO:0008270, IDA]; fibroblast growth factor binding [GO:0017134, IPI]; positive regulation of interleukin-1 alpha production [GO:0032730, IDA]; protein homodimerization activity [GO:0042803, IPI]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, IDA]; perinuclear region of cytoplasm [GO:0048471, IDA]; RAGE receptor binding [GO:0050786, IPI]	Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A a
P05109	S100A8	93	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1987-08-13	0	0	Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)	91	84	22	8	11	43	0	CP	1	1	1	GO:0002523;GO:0002544;GO:0005509;GO:0005576;GO:0005634;GO:0005737;GO:0005829;GO:0005856;GO:0005886;GO:0006914;GO:0006954;GO:0008017;GO:0008270;GO:0010043;GO:0018119;GO:0030307;GO:0030593;GO:0031012;GO:0032496;GO:0034121;GO:0034774;GO:0035425;GO:0035662;GO:0042742;GO:0043542;GO:0045111;GO:0045471;GO:0048306;GO:0050544;GO:0050729;GO:0050786;GO:0050832;GO:0051493;GO:0070062;GO:0070488;GO:1990660;GO:1990661;GO:2001244	leukocyte migration involved in inflammatory response [GO:0002523, IDA]; extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; nucleus [GO:0005634, HDA]; cytosol [GO:0005829, IDA]; autophagy [GO:0006914, IDA]; peptidyl-cysteine S-nitrosylation [GO:0018119, IMP]; neutrophil chemotaxis [GO:0030593, IDA]; extracellular matrix [GO:0031012, HDA]; intermediate filament cytoskeleton [GO:0045111, IDA]; positive regulation of inflammatory response [GO:0050729, IDA]; extracellular exosome [GO:0070062, HDA]; neutrophil aggregation [GO:0070488, IDA]; calprotectin complex [GO:1990660, IPI]; S100A8 complex [GO:1990661, IPI]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244, IDA]	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular function
P04271	S100B	92	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1987-03-20	0	0	Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)	154	85	27	9	34	15	0	CFP	1	1	1	GO:0001726;GO:0005102;GO:0005509;GO:0005576;GO:0005634;GO:0005654;GO:0005737;GO:0005829;GO:0007409;GO:0007417;GO:0007611;GO:0008270;GO:0008284;GO:0008360;GO:0031643;GO:0042802;GO:0042803;GO:0043025;GO:0043065;GO:0043123;GO:0044548;GO:0045471;GO:0045666;GO:0048156;GO:0048306;GO:0048471;GO:0048708;GO:0050786;GO:0050806;GO:0051384;GO:0051597;GO:0060291;GO:0071456;GO:0072347;GO:0097490;GO:1990138;GO:1990845;GO:2001015	ruffle [GO:0001726, IDA]; calcium ion binding [GO:0005509, EXP]; calcium ion binding [GO:0005509, IDA]; nucleus [GO:0005634, EXP]; nucleus [GO:0005634, IDA]; nucleoplasm [GO:0005654, IDA]; cytoplasm [GO:0005737, EXP]; cytoplasm [GO:0005737, IDA]; cytosol [GO:0005829, IDA]; zinc ion binding [GO:0008270, IDA]; identical protein binding [GO:0042802, IPI]; protein homodimerization activity [GO:0042803, IDA]; protein homodimerization activity [GO:0042803, IPI]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, IDA]; S100 protein binding [GO:0044548, IPI]; calcium-dependent protein binding [GO:0048306, IDA]; perinuclear region of cytoplasm [GO:0048471, IDA]; RAGE receptor binding [GO:0050786, IPI]	Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both i
P11684	SCGB1A1	91	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1989-10-01	1	0	Uteroglobin (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)	34	21	2	2	14	3	0	C	1	1	1	GO:0005576;GO:0005635;GO:0005737;GO:0007165;GO:0007565;GO:0007566;GO:0009410;GO:0010193;GO:0030141;GO:0032496;GO:0034021;GO:0034097;GO:0051384;GO:0070062;GO:0071774;GO:0097160	extracellular region [GO:0005576, IDA]; extracellular exosome [GO:0070062, HDA]	Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Q8TD33	SCGB1C1	95	secreted peptide / hormone / defensin	Inferred from homology	2.0	2006-02-21	1	0	Secretoglobin family 1C member 1 (Secretoglobin RYD5)	1	1	0	0	1	0	0		0	0	1	GO:0005576		
P0DMR2	SCGB1C2	95	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2014-11-26	1	0	Secretoglobin family 1C member 2	3	2	0	0	1	1	0		0	0	1	GO:0005576		
O95968	SCGB1D1	90	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2000-05-30	1	0	Secretoglobin family 1D member 1 (Lipophilin-A)	13	6	3	1	1	1	0	C	0	0	1	GO:0005576	extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]	May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
O95969	SCGB1D2	90	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2000-05-30	1	0	Secretoglobin family 1D member 2 (Lipophilin-B)	4	4	1	1	1	1	0	C	0	0	1	GO:0005576	extracellular region [GO:0005576, HDA]	May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
Q6XE38	SCGB1D4	83	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2004-11-09	1	0	Secretoglobin family 1D member 4 (IFN-gamma-inducible secretoglobin) (IIS)	2	2	0	1	1	0	0		0	0	1	GO:0005576		Seems to be involved in the regulation of chemotactic cell migration and invasion.
O75556	SCGB2A1	95	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2000-05-30	1	0	Mammaglobin-B (Lacryglobin) (Lipophilin-C) (Mammaglobin-2) (Secretoglobin family 2A member 1)	10	9	6	2	1	0	0	CP	0	1	1	GO:0005576;GO:0030521	extracellular region [GO:0005576, HDA]; extracellular region [GO:0005576, IDA]; androgen receptor signaling pathway [GO:0030521, IDA]	May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
Q13296	SCGB2A2	93	secreted peptide / hormone / defensin	Evidence at protein level	3.0	1997-11-01	1	0	Mammaglobin-A (Mammaglobin-1) (Secretoglobin family 2A member 2)	4	3	0	2	1	0	0		0	1	1	GO:0005576;GO:0030521		
Q4G0G5	SCGB2B2	96	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2008-07-01	1	0	Secretoglobin family 2B member 2 (Secretoglobin-like protein)	2	1	0	0	1	0	0		0	0	1	GO:0005576		
Q96PL1	SCGB3A2	93	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2002-01-23	1	0	Secretoglobin family 3A member 2 (Pneumo secretory protein 1) (PnSP-1) (Uteroglobin-related protein 1)	5	5	1	1	1	2	0	C	0	0	1	GO:0005576;GO:0071682	extracellular region [GO:0005576, EXP]	Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2
A0A411D538	SCPPPQ1	79	secreted peptide / hormone / defensin	Inferred from homology	1.0	2023-11-08	1	0	Secretory calcium-binding phosphoprotein proline- and glutamine-rich 1	2	2	0	0	1	1	0		0	0	1	GO:0005576		Tooth-associated epithelia protein that may participate in structuring the basal lamina at cell-tooth interface. {ECO:0000250|UniProtKB:D6QY17}.
O75711	SCRG1	98	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2000-05-30	1	0	Scrapie-responsive protein 1 (Scrapie-responsive gene 1 protein) (ScRG-1)	12	8	0	2	4	2	0		0	1	1	GO:0005576;GO:0005737;GO:0005794;GO:0007399;GO:0044306		
Q6UW10	SFTA2	78	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2004-11-23	1	0	Surfactant-associated protein 2 (Surfactant-associated protein G) (SP-G)	4	4	1	0	3	0	0	C	0	0	1	GO:0005576;GO:0005794;GO:0030133	Golgi apparatus [GO:0005794, EXP]	Putative surfactant protein. {ECO:0000305}.
P0C7M3	SFTA3	94	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2008-06-10	0	0	Surfactant-associated protein 3 (Surfactant-associated protein H) (SP-H)	19	19	5	0	2	12	0	CP	0	1	1	GO:0005576;GO:0005737;GO:0005789;GO:0042060;GO:0042599;GO:0045334	extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, EXP]; cytoplasm [GO:0005737, IDA]; wound healing [GO:0042060, IMP]	Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. {ECO:0000269|PubMed:29955092}.
P0DP57	SLURP2	97	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2017-07-05	1	0	Secreted Ly-6/uPAR domain-containing protein 2 (Secreted LY6/PLAUR domain-containing protein 2) (Secreted Ly-6/uPAR-related protein 2) (SLURP-2)	12	12	6	4	2	0	0	CFP	1	1	1	GO:0005576;GO:0005886;GO:0030548;GO:0030550;GO:0033130;GO:0045202;GO:0095500;GO:0099601	extracellular region [GO:0005576, IDA]; acetylcholine receptor regulator activity [GO:0030548, IDA]; acetylcholine receptor binding [GO:0033130, IDA]; acetylcholine receptor signaling pathway [GO:0095500, IDA]; regulation of neurotransmitter receptor activity [GO:0099601, IDA]	Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-con
A4D0T7	SMIM30	59	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2008-09-02	1	1	Small integral membrane protein 30 (Microprotein in antiviral immunity 1)	9	8	3	3	2	0	0	CP	0	1	1	GO:0005789;GO:0031966;GO:0060339	endoplasmic reticulum membrane [GO:0005789, IDA]; mitochondrial membrane [GO:0031966, IDA]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339, IMP]	Negatively regulates antiviral innate immune responses (PubMed:37656786). Disrupts the interaction of antiviral protein MAVS with innate immune receptor RIGI and inhibits MAVS aggregation, resulting in the repression of type I interferon signaling and innate immune responses (PubMed:37656786). {ECO:
Q9BQ49	SMIM7	75	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2007-04-17	1	1	Small integral membrane protein 7	1	1	0	0	1	0	0		0	0	1	GO:0016020		
A6NGZ8	SMIM9	99	secreted peptide / hormone / defensin	Inferred from homology	2.0	2008-09-02	1	1	Small integral membrane protein 9	1	1	0	0	1	0	0		0	0	1	GO:0005886		
P02814	SMR3B	79	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Submaxillary gland androgen-regulated protein 3B (Proline-rich peptide P-B) (Proline-rich protein 3) [Cleaved into: Peptide P-A; Peptide D1A]	11	5	1	2	1	1	0	C	1	1	1	GO:0004866;GO:0005576;GO:0051930;GO:0070062	extracellular exosome [GO:0070062, HDA]	
P00995	SPINK1	79	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Serine protease inhibitor Kazal-type 1 (Pancreatic secretory trypsin inhibitor) (Tumor-associated trypsin inhibitor) (TATI)	10	8	2	0	5	1	0	C	1	0	1	GO:0004866;GO:0004867;GO:0005576;GO:0030414;GO:0070062	extracellular region [GO:0005576, EXP]; extracellular exosome [GO:0070062, HDA]	Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). {ECO:0000250|UniProtKB:P09036, ECO:0000269|PubMed:7142173}.; In the male reproductive tract, binds to sperm heads whe
Q1W4C9	SPINK13	94	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2008-07-22	1	0	Serine protease inhibitor Kazal-type 13 (Hepatitis B virus DNA polymerase transactivated serine protease inhibitor) (Hespintor) (Serine protease inhibitor Kazal-type 5-like 3)	3	2	0	0	1	1	0		0	1	1	GO:0005576;GO:1902225		May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). {ECO:0000250}.
Q6IE38	SPINK14	97	secreted peptide / hormone / defensin	Inferred from homology	3.0	2008-05-20	1	0	Serine protease inhibitor Kazal-type 14	4	4	0	3	1	0	0		1	1	1	GO:0004867;GO:0005576;GO:0045861		May be a serine protease inhibitor. {ECO:0000250}.
P20155	SPINK2	84	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1991-02-01	1	0	Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II)	18	11	3	2	4	2	0	CP	1	1	1	GO:0001669;GO:0001675;GO:0004866;GO:0004867;GO:0005576;GO:0007286	acrosomal vesicle [GO:0001669, IDA]; spermatid development [GO:0007286, IMP]	As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-depe
O60575	SPINK4	86	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2000-05-30	1	0	Serine protease inhibitor Kazal-type 4 (Peptide PEC-60 homolog)	4	3	0	0	3	0	0		1	1	1	GO:0004867;GO:0005576;GO:0009410		
Q6UWN8	SPINK6	80	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2005-02-01	1	0	Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor)	9	9	0	3	1	5	0		1	1	1	GO:0004867;GO:0005576;GO:0045861		Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. {ECO:0000269|PubMed:20667819, ECO:0000269|PubMed:21439340}.
P58062	SPINK7	85	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2001-05-04	1	0	Serine protease inhibitor Kazal-type 7 (Esophagus cancer-related gene 2 protein) (ECRG-2)	20	6	0	4	2	0	0		1	1	1	GO:0004867;GO:0005576;GO:0006954;GO:0045861		Probable serine protease inhibitor.
P0C7L1	SPINK8	97	secreted peptide / hormone / defensin	Inferred from homology	2.0	2008-05-20	1	0	Serine protease inhibitor Kazal-type 8	1	1	0	0	1	0	0		0	0	1	GO:0005576		Probable serine protease inhibitor. {ECO:0000250}.
Q5DT21	SPINK9	86	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2008-05-20	1	0	Serine protease inhibitor Kazal-type 9 (Lymphoepithelial Kazal-type-related inhibitor 2)	9	6	1	2	2	1	0	F	1	1	1	GO:0004867;GO:0005576;GO:0045861	serine-type endopeptidase inhibitor activity [GO:0004867, IDA]	Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5. {ECO:0000269|PubMed:19190773, ECO:0000269|PubMed:19194479}.
P49223	SPINT3	89	secreted peptide / hormone / defensin	Evidence at protein level	2.0	1996-02-01	1	0	Kunitz-type protease inhibitor 3 (HKIB9)	2	2	0	0	2	0	0		1	0	1	GO:0004867;GO:0005576		
Q6UDR6	SPINT4	99	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2007-10-23	1	0	Kunitz-type protease inhibitor 4	2	2	0	0	2	0	0		1	0	1	GO:0004867;GO:0005576		
Q7Z2R9	SSBP3-AS1	100	secreted peptide / hormone / defensin	Uncertain	2.0	2007-01-09	1	0	Putative uncharacterized protein SSBP3-AS1 (SSBP3 antisense RNA 1) (SSBP3 antisense gene protein 1)	1	1	0	0	1	0	0		0	0	1	GO:0005576		
P02808	STATH	62	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-07-21	1	0	Statherin	40	16	0	4	5	7	0		1	1	1	GO:0001503;GO:0005576;GO:0005739;GO:0030197;GO:0030345;GO:0030500;GO:0030502;GO:0031640;GO:0042742;GO:0046541;GO:0046848;GO:0061844		Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
Q8N300	SVBP	66	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2006-05-02	0	0	Small vasohibin-binding protein (Coiled coil domain-containing protein 23)	34	27	19	3	3	2	0	CFP	1	1	1	GO:0005576;GO:0005737;GO:0005856;GO:0006508;GO:0008017;GO:0009306;GO:0010596;GO:0016504;GO:0031397;GO:0045177;GO:0061564;GO:1905048	proteolysis [GO:0006508, IDA]; microtubule binding [GO:0008017, IDA]; protein secretion [GO:0009306, IDA]; negative regulation of endothelial cell migration [GO:0010596, IGI]; peptidase activator activity [GO:0016504, IDA]; negative regulation of protein ubiquitination [GO:0031397, IDA]; apical part of cell [GO:0045177, IDA]; axon development [GO:0061564, IMP]; regulation of metallopeptidase activity [GO:1905048, IMP]	Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869, PubMed:31171830, PubMed:31235910, PubMed:31235911, PubMed:31270470, PubMed:31324789). This activity is critical for spindle function
P04155	TFF1	84	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1986-11-01	1	0	Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)	21	10	0	2	6	2	0		0	1	1	GO:0005576;GO:0005975;GO:0010039;GO:0030277;GO:0035902;GO:0043434		Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}.
Q07654	TFF3	80	secreted peptide / hormone / defensin	Evidence at protein level	5.0	1994-10-01	1	0	Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)	17	11	5	2	3	1	0	CF	1	1	1	GO:0005576;GO:0005737;GO:0010906;GO:0030141;GO:0030277;GO:0042802	extracellular region [GO:0005576, IDA]; cytoplasm [GO:0005737, EXP]; identical protein binding [GO:0042802, IPI]	Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). {ECO:0000269|PubMed:11694446}.
Q8TBQ9	TMEM167A	72	secreted peptide / hormone / defensin	Evidence at protein level	4.0	2006-07-25	1	1	Protein kish-A (Transmembrane protein 167) (Transmembrane protein 167A)	5	4	2	1	1	0	0	CP	0	1	1	GO:0000139;GO:0005794;GO:0009306;GO:0045054	Golgi apparatus [GO:0005794, IDA]; constitutive secretory pathway [GO:0045054, IGI]	Involved in the early part of the secretory pathway. {ECO:0000269|PubMed:19942856}.
Q9NRX6	TMEM167B	74	secreted peptide / hormone / defensin	Evidence at protein level	5.0	2006-12-12	1	1	Protein kish-B (Transmembrane protein 167B)	34	3	2	0	1	0	0	CP	0	1	1	GO:0000139;GO:0005794;GO:0045054	Golgi apparatus [GO:0005794, IDA]; constitutive secretory pathway [GO:0045054, IGI]	Involved in the early part of the secretory pathway. {ECO:0000269|PubMed:19942856}.
Q9H1F0	WFDC10A	79	secreted peptide / hormone / defensin	Inferred from homology	2.0	2002-10-19	1	0	WAP four-disulfide core domain protein 10A (Putative protease inhibitor WAP10A)	7	7	0	4	3	0	0		1	1	1	GO:0004867;GO:0005576;GO:0019731;GO:0030414;GO:0045087		
Q8IUB3	WFDC10B	73	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2003-06-16	1	0	Protein WFDC10B	8	7	0	4	3	0	0		1	1	1	GO:0004867;GO:0005576;GO:0019731;GO:0030414;GO:0045087		
Q8NEX6	WFDC11	87	secreted peptide / hormone / defensin	Inferred from homology	2.0	2002-12-06	1	0	Protein WFDC11	5	5	0	4	1	0	0		1	1	1	GO:0004867;GO:0005576;GO:0019731;GO:0045087		
Q8IUB5	WFDC13	93	secreted peptide / hormone / defensin	Evidence at protein level	3.0	2003-04-04	1	0	WAP four-disulfide core domain protein 13	7	5	0	4	1	0	0		1	1	1	GO:0004867;GO:0005576;GO:0019731;GO:0045087		Putative acid-stable proteinase inhibitor. {ECO:0000250}.
Q8NEX5	WFDC9	89	secreted peptide / hormone / defensin	Evidence at protein level	2.0	2002-12-06	1	0	Protein WFDC9	6	5	0	4	1	0	0		1	1	1	GO:0004867;GO:0005576;GO:0019731;GO:0045087