consensus:
- gene: Diap1
  text: UniProt and the review agree on DIAP1 as ubiquitin and NEDD8 ligase for Dronc, DrICE and Dcp-1.
  sources:
  - UniProt
discrepancy:
- gene: 18w
  text: Both sources name antibacterial humoral response; the review marks it over-annotated because 18w
    is not needed for adult antimicrobial responses and is not a bacterial pattern recognition receptor.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Ank2
  text: All sources describe locus-level Ank2 roles; the review covers Ank2-PE, a 697-aa product lacking
    the giant-isoform sequence, whose own role is undetermined.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Arg
  text: UniProt and the automated text give a nitrogen disposal or ammonium excretion role; the review
    notes flies lack a complete urea cycle and marks ammonium excretion over-annotated.
  sources:
  - UniProt
  - Alliance_Automated
- gene: Br140
  text: FlyBase calls Br140 a histone acetyltransferase; UniProt and the review describe a non-catalytic
    scaffold subunit of the Enok complex.
  sources:
  - Alliance_Imported
  - UniProt
- gene: CG10359
  text: The automated text asserts GPCR binding and GPCR signaling; the review removes both for this secreted
    fibrinogen-domain protein.
  sources:
  - Alliance_Automated
- gene: CG32086
  text: Both texts assert calcium ion sensor activity; the review notes the fly EFHB protein lacks a canonical
    calcium-binding EF-hand loop.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CG32086__Q8IQG0
  text: Both texts assert calcium ion sensor activity; the review removes it because the fly protein lacks
    a canonical calcium-binding EF-hand loop.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CG3226
  text: UniProt describes calcium-dependent ubiquitination; the review notes that flies have no S100 calcium-binding
    partners and removes S100 protein binding.
  sources:
  - UniProt
- gene: CG33090__Q7KT91
  text: The automated text names bile acid metabolic process; the review removes it as a mammal-specific
    GBA2 role.
  sources:
  - Alliance_Automated
- gene: CG3434
  text: The automated text says CG3434 enables queuine transglycosylase activity. UniProt and the review
    call it the non-catalytic accessory subunit that lacks the catalytic residues.
  sources:
  - Alliance_Automated
  - UniProt
- gene: CG3631
  text: The automated text gives protein serine/threonine kinase activity; UniProt and the review describe
    a xylose kinase, and the review removes the protein kinase row.
  sources:
  - Alliance_Automated
  - UniProt
- gene: CG42331
  text: The automated text lists 'cellular process involved in reproduction in multicellular organism',
    which the review removes.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CG4860
  text: UniProt and the automated text call CG4860 short-chain specific. The review modifies this to generic
    acyl-CoA dehydrogenase activity because only Arc42 loss reproduces the C4 profile.
  sources:
  - UniProt
  - Alliance_Automated
- gene: CG6051
  text: The automated text lists phosphatase activity; the review removes all phosphatase rows for this
    FYVE adaptor.
  sources:
  - Alliance_Automated
- gene: CG6830
  text: The automated text names ecdysteroid 22-kinase activity; the review says the substrate is unknown
    and leaves this row UNDECIDED.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Ccs
  text: UniProt's FUNCTION text describes a superoxide dismutase. The review says Ccs is not itself a
    dismutase and removes the IEA SOD activity rows from UniProt.
  sources:
  - UniProt
- gene: Cyp301a1
  text: FlyBase describes a detoxification P450; the review has no evidence for detoxification and centres
    on abdominal tergite formation.
  sources:
  - Alliance_Imported
- gene: Dhps
  text: FlyBase names the substrate 'eEF5'; UniProt and the review name the eIF5A precursor.
  sources:
  - Alliance_Imported
- gene: Dic4
  text: The automated text predicts sulfate, thiosulfate and phosphate transport; FlyBase and the review
    report no detectable exchange activity for Dic4.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: Dif
  text: The automated text lists salivary gland histolysis; the review removes that annotation because
    the cited paper reports the opposite.
  sources:
  - Alliance_Automated
- gene: Dscam1
  text: The automated text lists touch sensation; the review removes that annotation.
  sources:
  - Alliance_Automated
- gene: Eaf6
  text: The automated text lists DNA strand elongation involved in DNA replication; the review modifies
    this to G1/S transition because the cited assay did not measure elongation.
  sources:
  - Alliance_Automated
- gene: Eb1
  text: Wound healing (FlyBase) and melanotic encapsulation (automated) are both marked over-annotated
    in the review.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Egm
  text: FlyBase describes Egm as a beta-oxidation acyl-CoA dehydrogenase; UniProt and the review make
    it an MCIA complex I assembly factor whose dehydrogenase activity is undemonstrated in flies.
  sources:
  - Alliance_Imported
  - UniProt
- gene: EloB
  text: The UniProt text is mammalian (EPOP recruitment in embryonic stem cells) and omits the cullin-RING
    adaptor role that the review makes core.
  sources:
  - UniProt
- gene: GatC
  text: RefSeq gives GatC glutaminyl-tRNA synthase activity; UniProt and the review describe GatC as a
    non-catalytic structural subunit.
  sources:
  - RefSeq
  - UniProt
- gene: Gen
  text: UniProt says Gen does not cleave Holliday junctions; FlyBase, the automated text and the review
    describe symmetric Holliday junction resolution.
  sources:
  - UniProt
  - Alliance_Imported
- gene: Gfat1
  text: All sources assign full GFAT activity; the review says this accession (Gfat1-PF) lacks the Cys2
    nucleophile and glutaminase domain and cannot catalyse the reaction alone.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Gpdh3
  text: The automated text predicts glycerol-3-phosphate dehydrogenase activity; the review says Gpdh3
    lacks conserved catalytic and NAD-binding residues and its activity is untested.
  sources:
  - Alliance_Automated
- gene: Hand
  text: The automated text lists positive regulation of transcription elongation; the review modifies
    it to positive regulation of transcription.
  sources:
  - Alliance_Automated
- gene: HipHop
  text: The automated text leads with CENP-A chromatin assembly, which the review leaves undecided.
  sources:
  - Alliance_Automated
- gene: Hn
  text: All sources assign hydroxylase activity; the review says this accession (Hn-PD, residues 275-452)
    lacks the pterin-binding and regulatory regions and is not expected to be catalytic.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: IKKbeta
  text: UniProt says IKKbeta phosphorylates Cactus to activate Relish; the review gives Relish S528/S529
    as the substrate and says IKKbeta is not required for Cactus-dependent Toll signaling.
  sources:
  - UniProt
- gene: IKKepsilon
  text: The current automated text drops the antiviral innate immune response that the older RefSeq copy
    and the review (cGAS/STING core function) include.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Idh
  text: FlyBase places Idh NADPH regeneration in the peroxisome; the review removes or marks as over-annotated
    the peroxisome rows.
  sources:
  - Alliance_Imported
- gene: Ing5
  text: FlyBase calls Ing5 a histone acetyltransferase; the review and automated text treat it as an acetyltransferase
    activator subunit, with Enok as the catalytic subunit.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Lam
  text: Both automated texts lead with signaling receptor binding activity, which the review removes.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Lis-1
  text: FlyBase says Lis-1 is a non-catalytic PAF-AH subunit; the review states the fly protein does not
    bind the Drosophila PAF-AH alpha subunit homolog.
  sources:
  - Alliance_Imported
- gene: Lsp2
  text: The automated text lists motor neuron axon guidance and synaptic target inhibition; the review
    marks both as over-annotations, and also the LSP-1 'larval serum protein complex' for this homohexamer.
  sources:
  - Alliance_Automated
- gene: LysB
  text: The automated text gives defense response to Gram-negative bacterium; UniProt and the review say
    LysB is digestive and repressed on infection.
  sources:
  - Alliance_Automated
  - UniProt
- gene: MESK2
  text: Both texts say MESK2 enables serine hydrolase activity; the review marks this over-annotated because
    the nucleophile-elbow serine is replaced by glycine.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: MESK2__Q7KVN0
  text: Serine hydrolase activity is asserted, but the review argues MESK2 is noncatalytic and marks the
    row over-annotated.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Mef2
  text: The RefSeq copy lists carbohydrate storage among highlighted processes and omits muscle differentiation,
    the core role in the review.
  sources:
  - RefSeq
  - Alliance_Automated
- gene: Mo25
  text: The automated text says positive regulation of TORC1 signaling; the review modifies this, as the
    LKB1-Stlk-Mo25 complex restrains TORC1.
  sources:
  - Alliance_Automated
- gene: Mon1
  text: Automated texts say Mon1 enables GEF inhibitor activity; UniProt, FlyBase and the review describe
    it as the Rab7 GEF, and the review marks the inhibitor term over-annotated.
  sources:
  - Alliance_Automated
  - RefSeq
  - UniProt
- gene: Mst27D
  text: The automated text asserts microtubule plus-end binding and spindle assembly; the review says
    Mst27D binds along the lattice, marks plus-end terms over-annotated and removes spindle assembly.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: Mtpalpha
  text: Automated texts place Mtpalpha only in the peroxisome; the review accepts the mitochondrial inner
    membrane MTP complex and keeps peroxisome as non-core.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Mtpbeta
  text: Automated texts give acetyl-CoA C-acetyltransferase activity; the review corrects this to acetyl-CoA
    C-acyltransferase (long-chain 3-ketoacyl-CoA thiolase).
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Nepl15
  text: The automated text predicts metalloendopeptidase activity; the review finds the HExxH motif reads
    RQMLH and predicts Nepl15 is catalytically inactive.
  sources:
  - Alliance_Automated
- gene: Nepl19
  text: Both texts predict proteolysis; the review removes proteolysis because Nepl19 lacks the catalytic
    HExxH residues.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: NijA
  text: The automated texts and UniProt (by similarity) give homophilic cell-cell adhesion; the review
    marks cell-cell adhesion mediator activity over-annotated and keeps only Mmp1-shed ectodomain effects
    on substrate adhesion.
  sources:
  - Alliance_Automated
  - UniProt
- gene: Nprl3
  text: The automated text places Nprl3 in the GATOR2 complex; UniProt, FlyBase and the review place it
    in GATOR1.
  sources:
  - Alliance_Automated
  - UniProt
  - Alliance_Imported
- gene: NtR
  text: Both texts predict acetylcholine-gated channel activity and cholinergic synaptic transmission;
    the review marks these over-annotated because NtR lacks the vicinal loop-C cysteines and GEK selectivity
    ring.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Pak
  text: The automated text names autophagic cell death as a main process; the review marks it over-annotated.
  sources:
  - Alliance_Automated
- gene: Pcf11
  text: FlyBase says Pcf11 regulates RNA splicing; the reviews describe cleavage factor II, poly(A)-site
    choice and Pol II termination, with no splicing role.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Pcf11__A1Z9W4
  text: FlyBase describes Pcf11 as a splicing regulator; UniProt and the review describe cleavage factor
    II, Pol II termination and poly(A)-site choice.
  sources:
  - Alliance_Imported
  - UniProt
- gene: Pcf11__A1Z9W4
  text: The automated text leads with piRNA-guided transposon silencing, which the review keeps as non-core,
    and omits transcription termination.
  sources:
  - Alliance_Automated
- gene: Pde4
  text: RefSeq lists predicted cGMP phosphodiesterase activity. The review describes dnc as cAMP-specific
    and raises the cGMP IBA only as a question.
  sources:
  - RefSeq
- gene: Pde4__P12252
  text: RefSeq names predicted cGMP phosphodiesterase activity. The review and the other sources describe
    a cAMP-specific PDE4.
  sources:
  - RefSeq
- gene: Pld
  text: 'The automated text names gastrulation involving germ band extension as a lead process. The review
    marks that term as over-annotated: the shortened germ band follows cellularization defects.'
  sources:
  - Alliance_Automated
- gene: PolG2
  text: The automated text leads with DNA/RNA hybrid and ssRNA binding. UniProt says the subunit does
    not bind DNA, and the review leaves the hybrid binding UNDECIDED.
  sources:
  - Alliance_Automated
  - UniProt
- gene: Prx4
  text: FlyBase calls Prx4 an atypical 2-Cys peroxiredoxin. The review describes a typical 2-Cys peroxiredoxin
    of the AhpC/Prx1 family.
  sources:
  - Alliance_Imported
- gene: Pxd
  text: FlyBase describes Pxd as a glutathione-oxidizing antioxidant enzyme. UniProt, the automated text
    and the review describe the chorion-hardening heme peroxidase.
  sources:
  - Alliance_Imported
  - UniProt
- gene: Pxd
  text: The automated and RefSeq texts name human EPX as an ortholog. The review states Pxd has no vertebrate
    ortholog and belongs to an arthropod-specific expansion.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Rad9
  text: The automated and RefSeq texts lead with predicted 3'-5' exonuclease activity. The review marks
    this as over-annotated, transferred from early mammalian reports.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: RluA-1
  text: The automated text predicts rRNA pseudouridine synthesis. The review says the RPUSD2 subfamily
    has lost rRNA activity and acts on tRNA U32.
  sources:
  - Alliance_Automated
- gene: Roc1a
  text: UniProt says Roc1a is required for Ci but not Armadillo proteolysis. The review description lists
    Armadillo destruction among its SCF roles.
  sources:
  - UniProt
- gene: Roc1a
  text: FlyBase calls Roc1a a C2H2 zinc finger protein. The review describes a RING-H2 domain.
  sources:
  - Alliance_Imported
- gene: SCAP
  text: UniProt and the automated texts describe sterol-regulated SREBP processing and cholesterol synthesis.
    The review says flies cannot make sterols and regulate SREBP through phosphatidylethanolamine, and
    it removes the cholesterol biosynthesis annotation.
  sources:
  - UniProt
  - Alliance_Automated
  - RefSeq
- gene: SK
  text: UniProt says the channel is blocked by apamin (By similarity). FlyBase and the review say fly
    dSK is apamin insensitive.
  sources:
  - UniProt
  - Alliance_Imported
- gene: SK
  text: The automated text claims photoreceptor activity (light absorption). The review removes this annotation.
  sources:
  - Alliance_Automated
- gene: SREBP
  text: FlyBase says SREBP responds to reduced cholesterol. The review says fly SREBP processing is controlled
    by phosphatidylethanolamine.
  sources:
  - Alliance_Imported
- gene: Septin2
  text: The automated text says Sep2 enables GTPase activity. The review says recombinant Sep2 binds GTP
    but has no detectable GTPase activity.
  sources:
  - Alliance_Automated
- gene: Serinc
  text: FlyBase describes Serinc as a putative L-serine transporter. The review says serine incorporation
    has not been upheld and its lipid transport activity is undetermined.
  sources:
  - Alliance_Imported
- gene: Serinc__M9PFR2
  text: FlyBase calls Serinc a putative L-serine transporter. The review describes a lipid-binding membrane
    protein whose transport activity is undetermined.
  sources:
  - Alliance_Imported
- gene: Smurf
  text: UniProt calls Smurf a positive regulator of smoothened signaling through Patched degradation.
    The review accepts negative regulation of smoothened signaling through Smo ubiquitination.
  sources:
  - UniProt
- gene: Stim
  text: RefSeq states store-operated calcium channel activity and calcium-induced calcium release activity.
    The review treats Stim as the ER Ca2+ sensor and Orai regulator, and has neither term.
  sources:
  - RefSeq
- gene: Stlk
  text: The automated texts say Stlk is involved in positive regulation of TORC1 signaling; the review
    describes the LKB1-Stlk-Mo25 complex activating AMPK to restrain TORC1-driven growth.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Sur
  text: FlyBase says Sur is expressed almost exclusively in the embryonic heart; the review lists embryonic
    trachea, adult heart, corpora cardiaca and insulin-producing cells.
  sources:
  - Alliance_Imported
- gene: Suv3
  text: The automated texts give DNA helicase activity as the molecular function; the review marks it
    over-annotated and uses RNA helicase activity.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Tdrd3
  text: UniProt's spliceosome assembly, histone methylarginine reading and G3BP1 stress-granule roles
    come from human TDRD3 and are absent from the review; the review marks Cajal body, nuclear speck and
    mRNA processing as over-annotated.
  sources:
  - UniProt
- gene: Tl
  text: The automated text lists virion binding activity; the review states Toll does not bind microbial
    molecules directly.
  sources:
  - Alliance_Automated
- gene: Toll-7
  text: FlyBase says Toll-7 binds viral glycoproteins; the review treats direct glycoprotein binding as
    unresolved.
  sources:
  - Alliance_Imported
- gene: Top3beta
  text: FlyBase says Top3beta promotes transcription via Tdrd3 binding to methylated histones; the review
    describes Top3beta-Tdrd3 promoting siRNA-guided heterochromatin silencing.
  sources:
  - Alliance_Imported
- gene: Vhl
  text: The automated texts lead with transcription corepressor activity, which the review marks over-annotated.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Vps50
  text: The automated text places Vps50 in the GARP complex; the review describes Vps50 as the defining
    EARP subunit that replaces Vps54.
  sources:
  - Alliance_Automated
- gene: Zpr1
  text: UniProt and FlyBase place Zpr1 in EGFR/FGFR signaling; the review marks those terms over-annotated
    and treats Zpr1 as an eEF1A chaperone.
  sources:
  - UniProt
  - Alliance_Imported
- gene: amon
  text: FlyBase says amon directly cleaves Slit; UniProt cites one study for and one against, and the
    review does not mention Slit.
  sources:
  - Alliance_Imported
  - UniProt
- gene: aub
  text: The automated text places Aub in the Yb body, a location the review removes.
  sources:
  - Alliance_Automated
- gene: borr
  text: UniProt says Borr has no function in meiotic histone phosphorylation; the review says borr mutant
    cells lose H3S10 phosphorylation, and the UniProt sentence appears to come from the Australin study.
  sources:
  - UniProt
- gene: cact
  text: UniProt says Cactus is degraded by IKKbeta; the review describes Pelle-mediated phosphorylation
    and Slimb-dependent degradation downstream of Toll.
  sources:
  - UniProt
- gene: cav
  text: The automated text says telomeric repeat DNA binding, while UniProt and the review stress sequence-independent
    binding to chromosome ends.
  sources:
  - Alliance_Automated
  - UniProt
- gene: dac
  text: Automated and RefSeq texts assign sequence-specific DNA-binding transcription factor activity;
    the review says no DNA binding has been shown and treats Dac as a cofactor of Eya.
  sources:
  - Alliance_Automated
  - RefSeq
  - Alliance_Imported
- gene: dl__P15330
  text: UniProt says Dorsal promotes expression of zen and dpp; the review states that Dorsal represses
    these dorsal genes with Groucho-recruiting cofactors.
  sources:
  - UniProt
- gene: ey
  text: The automated text names PAX4 as the human ortholog and omits eye development; the review treats
    ey as the Pax6 ortholog at the top of the retinal determination network.
  sources:
  - Alliance_Automated
- gene: eya
  text: UniProt says Eya regulates transcription through its phosphatase activity; the review says the
    phosphatase is dispensable for eye development and acts in axon pathfinding.
  sources:
  - UniProt
- gene: frc
  text: FlyBase lists UDP-glucose as a transported substrate; the review records conflicting evidence,
    including a NOT UDP-glucose transporter annotation.
  sources:
  - Alliance_Imported
- gene: glo
  text: FlyBase and the automated text present nurse cell chromatin organization as a Glo function; the
    review treats it as a downstream phenotype of RNA regulation (MARK_AS_OVER_ANNOTATED).
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: mTor
  text: The automated and RefSeq texts lead with chromatin DNA binding, which the review marks as over-annotated.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: metro
  text: The automated text assigns predicted kinase and ATP binding activity; the review removes kinase
    activity because the MAGUK GUK domain lacks catalytic residues.
  sources:
  - Alliance_Automated
- gene: msk
  text: The automated text leads with snRNA binding, which the review marks over-annotated, and omits
    the import receptor activity for ERK, Mad and Yorkie.
  sources:
  - Alliance_Automated
- gene: mud
  text: The automated text assigns DNA binding and thermosensory behavior; the review removes DNA binding
    and treats Mud as a Pins-recruited microtubule-binding spindle orientation effector.
  sources:
  - Alliance_Automated
- gene: mus312
  text: UniProt says MUS312 has endonuclease activity towards branched DNA; the review and FlyBase present
    it as a non-catalytic scaffold whose nuclease partners do the cutting.
  sources:
  - UniProt
  - Alliance_Imported
- gene: mus81
  text: UniProt suggests MUS81 may repair meiotic double-strand breaks; the review states fly MUS81-MMS4
    is not needed for meiotic crossing over.
  sources:
  - UniProt
- gene: neur
  text: The automated text never names Notch, the gene's main pathway, and gives long-term memory as a
    headline process; the review keeps memory as non-core.
  sources:
  - Alliance_Automated
- gene: olf413
  text: Both sources assign tyramine beta-hydroxylase activity; the review treats the substrate as undetermined
    and annotates only a generic ascorbate-dependent monooxygenase activity.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: pnr
  text: UniProt and FlyBase describe pnr through achaete-scute activation, while the automated text gives
    only cardiac and closure roles; the review treats both as core.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: ptc
  text: UniProt gives a cholesterol-transport mechanism for Smo inhibition by similarity; the review supports
    a phospholipid (PI4P, phosphatidic acid) mechanism in Drosophila.
  sources:
  - UniProt
- gene: rasp
  text: The automated text gives protein-cysteine S-palmitoyltransferase activity, while the review says
    Rasp makes an amide-linked N-palmitoyl cysteine.
  sources:
  - Alliance_Automated
- gene: rgn
  text: The automated text gives carbohydrate binding; the review says this is not established for Rgn.
  sources:
  - Alliance_Automated
- gene: rpr
  text: UniProt says Reaper acts on the caspase Dredd; the review describes Reaper as a DIAP1 antagonist
    that promotes DIAP1 degradation, with no Dredd role.
  sources:
  - UniProt
- gene: sima
  text: The automated text never mentions hypoxia, the core role of this HIF-alpha ortholog, and leads
    with insulin receptor signalling.
  sources:
  - Alliance_Automated
- gene: smo
  text: UniProt describes Smo activation by cholesterol and translocation to the primary cilium; the review
    states fly epithelia transduce Hh without a cilium, through the C-tail and Costal-2/Fused.
  sources:
  - UniProt
- gene: spi
  text: UniProt writes 'Ligand for the EGF receptor (Gurken)'; Gurken is another EGFR ligand, not the
    receptor.
  sources:
  - UniProt
- gene: tin
  text: The automated text gives human NKX2-2 as the ortholog; the review describes tin as the ortholog
    of Nkx2-5.
  sources:
  - Alliance_Automated
- gene: ttv
  text: Both sources assign heparan sulfate co-polymerase activity, but the review states the D5SHU8 ttv-PC
    product lacks the N-terminal anchor and GT47 domain and its activity is unstudied.
  sources:
  - Alliance_Imported
  - Alliance_Automated
gap:
- gene: AGO3
  text: UniProt says AGO3 is involved in transposon silencing in the adult brain (PubMed:23559253); the
    review does not mention a brain role.
  sources:
  - UniProt
- gene: Acat1
  text: FlyBase says Acat1 also performs the last step of fatty acid beta-oxidation; the review places
    Acat1 in ketone body and isoleucine metabolism only.
  sources:
  - Alliance_Imported
- gene: Actbeta
  text: FlyBase names hemocyte development and body size as Actbeta roles; the review does not cover either.
  sources:
  - Alliance_Imported
- gene: BicD
  text: UniProt names a role in annulate lamellae biogenesis (PubMed:31626769); the review does not mention
    annulate lamellae.
  sources:
  - UniProt
- gene: Buffy
  text: FlyBase links Buffy loss to altered larval energy metabolism; the review does not mention energy
    metabolism.
  sources:
  - Alliance_Imported
- gene: CG34171
  text: No source says CG34171 is a catalytically inactive serine protease homolog (SPH244), the one firm
    fact in the review.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CG34171__A8DZ15
  text: The text does not state the pseudoprotease status (Phe in place of the catalytic serine) that
    the review treats as the defining feature.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CG4793
  text: The text does not mention that depletion increases encapsulation of parasitoid eggs, the review's
    core role.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CG6836
  text: The automated text says CG6836 is used to study chromosome 3q29 microdeletion syndrome; the review
    does not mention this.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: CRY
  text: No source names TIMELESS binding or JETLAG/CUL1-mediated TIM degradation, which the review treats
    as the core entrainment mechanism.
  sources:
  - UniProt
  - Alliance_Automated
- gene: Caf1-105
  text: FlyBase says Caf1-105 contributes to Notch signaling; the review does not mention Notch.
  sources:
  - Alliance_Imported
- gene: Ced-12
  text: FlyBase names embryonic cellularization; the review does not mention it.
  sources:
  - Alliance_Imported
- gene: Cul1
  text: UniProt describes a role in Johnston's organ organization and auditory transduction via Ubr3,
    zip and ck; the review does not mention it.
  sources:
  - UniProt
- gene: CycA
  text: Neither source mentions the essential role of keeping Fzr inactive in G2, which the review treats
    as CycA's key mitotic function.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Cyfip
  text: UniProt names a role in mitochondrial activity and GABA signalling for social behaviour (PMID:32200800);
    the review does not cover it.
  sources:
  - UniProt
- gene: Dci
  text: FlyBase says Dci overexpression extends lifespan, improves stress tolerance and activates foxo;
    the review does not mention this.
  sources:
  - Alliance_Imported
- gene: Dcp-1
  text: UniProt says Dcp-1 cleaves Parp1 and that zygotic loss causes melanotic tumours; the review does
    not mention either.
  sources:
  - UniProt
- gene: Diap2
  text: UniProt says Diap2 regulates ion channel expression (PubMed:24374974); the review does not mention
    ion channels.
  sources:
  - UniProt
- gene: Dif
  text: UniProt cites Dif roles in melanization via Spn27A and in elimination of unfit cells during cell
    competition; neither is mentioned in the review.
  sources:
  - UniProt
- gene: Elba2
  text: No source mentions the review's H1-like role of Elba2 in internucleosomal spacing and nuclear
    compaction in syncytial embryos.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: EloB
  text: FlyBase says the Elongin complex interacts with the chromatin factor Corto; the review does not
    mention Corto.
  sources:
  - Alliance_Imported
- gene: EloC
  text: FlyBase says the Elongin complex interacts with Corto; the EloC review does not mention Corto.
  sources:
  - Alliance_Imported
- gene: Fer1HCH
  text: UniProt cites ferroptosis protection (PubMed:31568497), hemocyte differentiation (PubMed:29237257)
    and zinc/manganese storage; the review mentions none of these.
  sources:
  - UniProt
- gene: Fer2LCH
  text: UniProt cites a role of Fer2LCH in circadian rhythm maintenance (PubMed:22885802); the review
    does not mention circadian rhythms.
  sources:
  - UniProt
- gene: G6pd
  text: None of the sources mentions the review's SIK3 activation, oxidative stress resistance or lifespan
    extension on overexpression.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: Git
  text: UniProt mentions roles in microtubule nucleation via Pak and in cytokinesis (by similarity); the
    review covers neither.
  sources:
  - UniProt
- gene: GstO1
  text: 'No source mentions the review''s main fly-specific role: S-glutathionylation of the BMP ligand
    Gbb restraining NMJ growth.'
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Hem
  text: FlyBase names a role in asymmetric division of neural precursors (insc and numb localization);
    the review does not mention it.
  sources:
  - Alliance_Imported
- gene: Hem
  text: UniProt's only claim, a role in oocyte growth, is not covered in the review.
  sources:
  - UniProt
- gene: Hsp27
  text: FlyBase names roles in eye morphology and polyglutamine toxicity; the review mentions neither.
  sources:
  - Alliance_Imported
- gene: IKKepsilon
  text: FlyBase says IKKepsilon negatively regulates protein kinase C; the review does not cover a PKC
    role.
  sources:
  - Alliance_Imported
- gene: Lst8
  text: FlyBase cites a Crtc-dependent growth role; the Lst8 review and notes do not mention Crtc.
  sources:
  - Alliance_Imported
- gene: Nf-YA
  text: FlyBase names a thorax development role; the Nf-YA review does not mention thorax development.
  sources:
  - Alliance_Imported
- gene: Nf-YB
  text: FlyBase names thorax development and the automated text positive regulation of MAPK cascade; neither
    appears in the Nf-YB review.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Psn
  text: Neither the automated nor the RefSeq text mentions Notch processing, which the review treats as
    the core function.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Ran
  text: The automated text never mentions nucleocytoplasmic transport, which the review treats as Ran's
    core function.
  sources:
  - Alliance_Automated
- gene: Rel
  text: The automated text does not mention the Imd pathway or antibacterial defense, the review's main
    core function.
  sources:
  - Alliance_Automated
- gene: RluA-1
  text: No source mentions the nociceptor hypersensitivity and dendrite branching phenotypes described
    in the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: Rubicon
  text: The automated text omits the negative regulation of autophagy, the lifespan effect and the paternal
    mitochondria elimination role described in the review.
  sources:
  - Alliance_Automated
- gene: SKIP
  text: The automated text omits the Shal K+ channel interaction, the basis of the gene name.
  sources:
  - Alliance_Automated
- gene: Sk1
  text: FlyBase names cell proliferation, differentiation and muscle cell repair roles. The review does
    not cover them.
  sources:
  - Alliance_Imported
- gene: Spase12
  text: Neither source mentions that spase12 null alleles are embryonic lethal, as the review records.
  sources:
  - UniProt
  - Alliance_Automated
- gene: Su-var-2-10
  text: The FlyBase text omits the SUMO E3 ligase activity and the Piwi/Panx-linked SetDB1 recruitment
    that the review treats as core.
  sources:
  - Alliance_Imported
- gene: Sur
  text: The FlyBase claim of increased oxidative stress in Sur-deficient adult hearts is not mentioned
    in the review.
  sources:
  - Alliance_Imported
- gene: Tace
  text: Neither text names Eiger, the TNF ligand that the review treats as the main Tace substrate.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: Tango5
  text: Neither text mentions autophagosome formation, which the review treats as a core experimentally
    shown role.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Tango5__Q9W2S1
  text: Neither text mentions the autophagosome formation role documented in the review.
  sources:
  - Alliance_Automated
  - RefSeq
- gene: Tcs5
  text: FlyBase says Tcs5 is regulated by Akt and Rab35; the review does not mention either.
  sources:
  - Alliance_Imported
- gene: Tcs5
  text: The automated text omits KEOPS complex membership and t6A tRNA modification, the core role in
    the review.
  sources:
  - Alliance_Automated
- gene: Toll-7
  text: FlyBase omits the neurotrophin receptor, axon targeting and olfactory partner matching roles that
    UniProt and the review treat as core.
  sources:
  - Alliance_Imported
- gene: TyrRS
  text: The automated text omits the secreted EMAP-fragment chemoattractant role that the review adds
    as NEW.
  sources:
  - Alliance_Automated
- gene: Usp12-46
  text: The polyglutamine/huntingtin neuroprotection in UniProt is not mentioned in the review.
  sources:
  - UniProt
- gene: Vhl
  text: FlyBase says Vhl stabilizes the endocytic factor Awd; the review mentions Breathless endocytosis
    but not Awd.
  sources:
  - Alliance_Imported
- gene: Vps29
  text: UniProt places Vps29 in the commander complex; the review mentions retromer and retriever only.
  sources:
  - UniProt
- gene: Vps53
  text: FlyBase says Vps53 is needed for secretory granule maturation and to prevent early granule degradation;
    the review does not mention this.
  sources:
  - Alliance_Imported
- gene: Zpr1
  text: FlyBase says Zpr1 contributes to spliceosome snRNP assembly; the review does not cover this.
  sources:
  - Alliance_Imported
- gene: awd
  text: FlyBase names Pvr as an endocytic cargo and a role in border cell migration; the review mentions
    neither.
  sources:
  - Alliance_Imported
- gene: awd__P08879
  text: FlyBase names Pvr as an endocytic cargo and a role in border cell migration; the review mentions
    neither.
  sources:
  - Alliance_Imported
- gene: cno
  text: Neither text mentions the Canoe-Pins-RanGTP role in recruiting Mud for neuroblast spindle orientation,
    a core function in the review.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: cos
  text: UniProt's hedged role for Cos2 in the gut uracil/Duox immune response is not covered in the cos
    review.
  sources:
  - UniProt
- gene: crc
  text: FlyBase says crc regulates glycolytic genes in the ER-stress unfolded protein response; the review
    does not cover glycolytic targets.
  sources:
  - Alliance_Imported
- gene: didum
  text: Neither text names Rab11/dRip11-dependent transport of rhodopsin vesicles to the rhabdomere, a
    core function in the review.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: dlg1
  text: Neither source names the postsynaptic NMJ scaffold role (Fas2 and Shaker clustering) or the Pins/Khc-73
    spindle orientation role that the review treats as core.
  sources:
  - UniProt
  - Alliance_Automated
- gene: fu
  text: Neither text mentions the Fu-Smurf ubiquitination of Thickveins in germline stem cell differentiation,
    a core function in the review.
  sources:
  - UniProt
  - Alliance_Automated
- gene: fz2
  text: Neither source names Wingless, Arrow or the Frizzled Nuclear Import pathway at the NMJ, which
    the review treats as core.
  sources:
  - UniProt
  - Alliance_Automated
- gene: grim
  text: UniProt says Grim acts on the caspase Dredd; the review covers only IAP antagonism and mitochondrial
    remodeling.
  sources:
  - UniProt
- gene: hid
  text: FlyBase says Ras/MAPK directly phosphorylates Hid to suppress apoptosis; the review covers only
    Ras-mediated down-regulation of hid expression and leaves direct phosphorylation as a question.
  sources:
  - Alliance_Imported
- gene: hid
  text: UniProt says Hid acts on the caspase Dredd; the review does not mention Dredd.
  sources:
  - UniProt
- gene: jumu
  text: FlyBase lists dendrite formation among jumu roles; the review does not cover it.
  sources:
  - Alliance_Imported
- gene: koi
  text: FlyBase says koi is involved in double-strand break repair; the review does not cover DNA repair.
  sources:
  - Alliance_Imported
- gene: msk
  text: FlyBase says msk is involved in muscle attachment; the review does not cover muscle attachment.
  sources:
  - Alliance_Imported
- gene: msl-1
  text: UniProt says MSL1 acts with Cdk7 to promote Pol II CTD Ser5 phosphorylation at promoters; the
    review mentions promoter binding but not this role.
  sources:
  - UniProt
- gene: mts
  text: No source mentions the mitotic and centriole duplication roles (PP2A-Tws stabilizing Plk4) or
    STRIPAK restraint of Hippo that the review treats as core.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: mus304
  text: No source names MEI-41 or the telomere-protection role that the review covers.
  sources:
  - UniProt
  - Alliance_Automated
  - RefSeq
- gene: nAChRalpha2
  text: Neither source names the Dalpha1/Dbeta2 partners, the neonicotinoid sensitivity or the mushroom
    body output neuron role in appetitive memory that the review describes.
  sources:
  - UniProt
  - Alliance_Automated
- gene: nudE
  text: No source names Lis1 or cytoplasmic dynein, which the review gives as NudE's core partners.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: olf413
  text: Neither source mentions the embryonic motor axon growth and pathfinding defects reported in the
    review.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: park
  text: Neither FlyBase nor the automated text names PINK1 or mitophagy, the core pathway in the review.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: pav
  text: Neither source mentions the neuronal role as a brake on kinesin-1-driven microtubule sliding that
    the review lists as a core function.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: piwi
  text: UniProt says Piwi mediates canalization with Hop and Hsp83; the review does not mention canalization.
  sources:
  - UniProt
- gene: rictor
  text: FlyBase credits rictor with roles in long-term memory and mitochondrial quality control that the
    review does not cover.
  sources:
  - Alliance_Imported
- gene: scat
  text: FlyBase says scat is needed for secretory granule maturation and to prevent early granule degradation;
    the review does not mention secretory granules.
  sources:
  - Alliance_Imported
- gene: sea
  text: FlyBase lists phosphoenolpyruvate as an exchange substrate and a central role in fatty acid and
    sterol biosynthesis; the review covers neither.
  sources:
  - Alliance_Imported
- gene: sgg
  text: No source mentions Sgg phosphorylation of Ci in Hedgehog signalling or of Timeless in the circadian
    clock, both core functions in the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: tub
  text: UniProt says Tube has a role in pupal pattern formation; the review does not mention it.
  sources:
  - UniProt
- gene: tws
  text: No source mentions the PP2A-Tws role in mitotic exit or centriole duplication through Plk4, both
    core functions in the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: wdb
  text: FlyBase says Wdb regulates Hedgehog signalling, and the automated text names lifespan and lipid
    storage; the review covers none of these.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: wdb
  text: No source mentions the centromeric PP2A-B56 role in meiotic cohesion that the review treats as
    core.
  sources:
  - Alliance_Imported
  - Alliance_Automated
  - RefSeq
- gene: wuho
  text: UniProt names nanos mRNA repression, microRNA suppression and ribosome biogenesis with Mei-P26;
    the review does not mention them.
  sources:
  - UniProt
insight:
- gene: CG3515
  text: The text calls CG3515 the WDR82 ortholog, but the review says the conserved ortholog is Wdr82
    (CG17293) and that the fly COMPASS purified from S2 cells contains Wdr82, not CG3515.
  sources:
  - Alliance_Automated
- gene: Caf1-55
  text: FlyBase describes only the MuvB role and UniProt omits it; the review lists both among eight or
    more complexes.
  sources:
  - Alliance_Imported
  - UniProt
- gene: Dic1
  text: The FlyBase claim of a main role in gluconeogenesis is extrapolated from mammalian liver; the
    review keeps gluconeogenesis only as non-core.
  sources:
  - Alliance_Imported
- gene: Mettl1
  text: UniProt names mRNA and miRNA substrates; the review keeps a broader RNA guanine-N7 methylation
    row and raises fly mRNA/miRNA m7G as an open question.
  sources:
  - UniProt
- gene: Sp7
  text: The review notes that genetic and biochemical studies disagree on whether Sp7 cleaves PPO1 directly
    or acts upstream of MP1. UniProt states direct cleavage as fact.
  sources:
  - UniProt