discrepancy:
- gene: AAD3
  text: The automated text predicts aryl-alcohol dehydrogenase activity. The review reports that purified
    Aad3p is inactive toward aryl-aldehydes and lacks the catalytic tyrosine.
  sources:
  - Alliance_Automated
- gene: ACH1
  text: UniProt links Ach1 to cholesterol synthesis and melatonin acetylation. The review describes a
    mitochondrial succinyl-CoA:acetate CoA-transferase.
  sources:
  - UniProt
- gene: ACO2
  text: SGD and the automated text describe a TCA-cycle aconitase. UniProt and the review describe a homocitrate
    dehydratase that cannot replace Aco1p in the TCA cycle.
  sources:
  - Alliance_Imported
  - Alliance_Automated
  - UniProt
- gene: ACP1
  text: UniProt calls Acp1 an accessory subunit of Complex I. The review notes S. cerevisiae lacks Complex
    I.
  sources:
  - UniProt
- gene: AGP2
  text: UniProt calls Agp2 a general amino acid permease that transports carnitine. SGD says it lacks
    transport activity and regulates transporter genes, which the review favours.
  sources:
  - UniProt
  - Alliance_Imported
- gene: ALG11
  text: SGD says Alg11 adds mannoses to the Man5GlcNAc2-PP-dolichol intermediate. UniProt and the review
    say it converts Man3 to Man5.
  sources:
  - Alliance_Imported
  - UniProt
- gene: ALG13
  text: The automated text locates Alg13 to the cytoplasmic side of the Golgi membrane. The review says
    the source paper places it at the cytosolic face of the ER.
  sources:
  - Alliance_Automated
- gene: ARO3
  text: The automated text locates Aro3 in the mitochondrion and nucleus; the review marks the mitochondrion
    row over-annotated and describes a cytosolic enzyme.
  sources:
  - Alliance_Automated
- gene: ARO9
  text: The automated text gives aromatic-amino-acid:2-oxoglutarate transaminase activity, but UniProt
    and the review say Aro9 does not accept 2-oxoglutarate.
  sources:
  - Alliance_Automated
  - UniProt
- gene: ASP1
  text: The automated text places Asp1 in the periplasm; SGD and the review describe it as cytosolic,
    and the review removes the periplasmic row.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: BIO1
  text: SGD and the automated text describe BIO1 as a pimeloyl-CoA synthetase (CoA ligase); the review
    places it in the PhyH Fe(II)/2-oxoglutarate oxygenase family and calls the reaction unknown.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: BNA4
  text: The automated text locates Bna4 only in the peroxisome; the review accepts mitochondrial outer
    membrane as the main site and keeps peroxisome as non-core.
  sources:
  - Alliance_Automated
- gene: BTS1
  text: UniProt describes the reaction as three IPP additions onto DMAPP; the review marks the DMAPP and
    FPP synthase annotations as over-annotations and says the physiological reaction uses FPP made by
    Erg20p.
  sources:
  - UniProt
- gene: CAB2
  text: UniProt calls the PPCS reaction the first step of CoA biosynthesis; SGD and the review place it
    second, after pantothenate kinase (Cab1).
  sources:
  - UniProt
  - Alliance_Imported
- gene: CAB4
  text: The automated text gives Cab4 dephospho-CoA kinase activity; the review removes that IBA because
    Cab4 is a single-domain PPAT and Cab5 is the DPCK.
  sources:
  - Alliance_Automated
- gene: CAF120
  text: The automated text predicts protein kinase activity; the review removes it as an over-propagated
    IBA because Caf120 has only a PH domain and disordered regions.
  sources:
  - Alliance_Automated
- gene: CAK1
  text: The automated text calls Cak1 an ortholog of human CDK4 and CDK6 and imports their diseases; the
    review describes a monomeric fungal-specific CAK distinct from CDK7 and CDKs.
  sources:
  - Alliance_Automated
- gene: CBR1
  text: The automated text lists 2-(3-amino-3-carboxypropyl)histidine synthase activity; the review modifies
    it because that is the Dph1-Dph2 reaction and Cbr1 only reduces Dph3.
  sources:
  - Alliance_Automated
- gene: CDA2
  text: The automated text says Cda2 is active in the cytosol and involved in chitin catabolism; the review
    removes cytosol (secreted, glycosylated enzyme) and modifies catabolism because deacetylation makes
    chitosan rather than degrading chitin.
  sources:
  - Alliance_Automated
- gene: CDC21
  text: SGD names the human complementing homolog TYMSOS (TYMS opposite strand, a non-coding RNA); the
    automated text and the review name TYMS.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: CDC5
  text: The automated text says Cdc5 binds centromeric DNA; the review modifies that annotation because
    the evidence is cohesin-mediated chromatin association and Cdc5 has no DNA-binding domain.
  sources:
  - Alliance_Automated
- gene: CHD1
  text: The automated text gives histone H3K4me3 reader activity; the review's description says yeast
    Chd1 chromodomains do not bind H3K4me3 and the annotation is left UNDECIDED.
  sources:
  - Alliance_Automated
- gene: CIT2
  text: UniProt ties Cit2 to the TCA cycle as its rate-limiting enzyme; the review's core function is
    the glyoxylate cycle.
  sources:
  - UniProt
- gene: CNE1
  text: Automated text states predicted calcium ion binding; the review removes this because direct yeast
    biochemistry argues against it.
  sources:
  - Alliance_Automated
- gene: COQ1
  text: Automated text says heptaprenyl (C35) diphosphate synthase; SGD and the review say hexaprenyl
    (C30), for Q6.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: COQ6
  text: UniProt says Coq6 also performs the C1 hydroxylation downstream of COQ4; the review says this
    step is a COQ4-dependent oxidative decarboxylation, not a Coq6 reaction.
  sources:
  - UniProt
- gene: COQ8
  text: Automated text claims protein kinase activity; SGD and the review say Coq8 lacks canonical protein
    kinase activity and acts as an ATPase.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: COX17
  text: Automated text includes protein farnesylation; the review says this annotation comes from a paper
    about COX10, not Cox17.
  sources:
  - Alliance_Automated
- gene: COX19
  text: SGD calls Cox19 a putative copper metallochaperone delivering copper to COX; UniProt and the review
    describe a chaperone for Cox11 rather than a copper donor.
  sources:
  - Alliance_Imported
  - UniProt
- gene: CPT1
  text: UniProt says Cpt1 prefers CDP-monomethylethanolamine; the review says it is relatively specific
    for CDP-choline.
  sources:
  - UniProt
- gene: CYB5
  text: SGD singles out sterol C5-6 desaturation; the review's core role is C-4 demethylation (Erg25)
    and Erg11 support, with Erg3 desaturation only a suggested question.
  sources:
  - Alliance_Imported
  - UniProt
- gene: DAK1
  text: UniProt says Dak1 phosphorylates glyceraldehyde; the review says this is inferred from mammalian
    triokinase and not shown in yeast.
  sources:
  - UniProt
- gene: DAK2
  text: UniProt says Dak2 phosphorylates glyceraldehyde; the review says this is not shown for the yeast
    enzyme.
  sources:
  - UniProt
- gene: DCI1
  text: SGD says the dienoyl-CoA isomerase identification is disputed. UniProt and the review accept the
    3,5-2,4 di-isomerase activity and doubt only a physiological 3,2-isomerase role.
  sources:
  - Alliance_Imported
  - UniProt
- gene: DEG1
  text: 'The automated text says DEG1 is active in mitochondrion. The review removes that location: mitochondrial
    tRNAs are modified, but direct mitochondrial localization was not shown.'
  sources:
  - Alliance_Automated
- gene: DFG10
  text: SGD describes a polyprenol reductase. The review and UniProt cite PMID:38821050 showing Dfg10
    reduces polyprenal to dolichal and has no activity on polyprenol.
  sources:
  - Alliance_Imported
  - UniProt
- gene: DNM1
  text: UniProt calls Dnm1 a microtubule-associated protein. The review marks microtubule and microtubule
    binding as over-annotations.
  sources:
  - UniProt
- gene: DOT5
  text: UniProt gives DOT5 roles in telomere silencing and telomere length. The review attributes the
    telomeric-silencing defects to overexpression and marks the telomeric location as over-annotated.
  sources:
  - UniProt
- gene: DUG1
  text: 'UniProt and SGD place Dug1 in a Dug1-Dug2-Dug3 complex. The review finds the heteromeric complex
    unsupported: Dug1 is a homodimer acting after (Dug2-Dug3)2.'
  sources:
  - UniProt
  - Alliance_Imported
- gene: DUG2
  text: The automated text gives Dug2 omega peptidase activity. The review says Dug2 is a non-catalytic
    scaffold whose M20A-like domain lacks peptidase activity.
  sources:
  - Alliance_Automated
- gene: ERG12
  text: UniProt's pathway text (also used for ERG19 and ERG20) says the mevalonate-to-FPP module occurs
    in the vacuole. The review places these enzymes in the cytosol and marks vacuole annotations as over-annotated
    or removed.
  sources:
  - UniProt
- gene: ERG20
  text: The automated text gives ERG20 isopentenyl-diphosphate delta-isomerase activity. The review leaves
    this row undecided; that step belongs to IDI1.
  sources:
  - Alliance_Automated
- gene: ERG3
  text: Automated text locates Erg3 in the ER lumen; the review modifies this IDA row to ER membrane because
    only the tagged N-terminus faces the lumen.
  sources:
  - Alliance_Automated
- gene: ERG6
  text: SGD and the automated text place Erg6 in mitochondria (outer membrane); the review marks the outer-membrane
    proteome row as over-annotated, explained by co-purifying lipid droplet/ER contacts.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: ERG8
  text: UniProt says the second (mevalonate) module is carried out in the vacuole; SGD and the review
    describe Erg8 as a soluble cytoplasmic protein.
  sources:
  - UniProt
  - Alliance_Imported
- gene: ESL1
  text: Automated text says Esl1 is predicted to act in nonsense-mediated decay; the review removes this
    because single and double esl mutants do not accumulate NMD substrates.
  sources:
  - Alliance_Automated
- gene: EXG1
  text: Automated text gives glucan endo-1,6-beta-glucosidase activity; the review modifies this IDA row
    to beta-glucosidase because the activity is exo/small-substrate, not endo.
  sources:
  - Alliance_Automated
- gene: FOX2
  text: UniProt calls Fox2 a hydratase-dehydrogenase-epimerase and the automated text gives (3S)-hydroxyacyl-CoA
    dehydrogenase; the review states the enzyme lacks epimerase and (3S) activities and works through
    (3R)-hydroxyacyl-CoA.
  sources:
  - UniProt
  - Alliance_Automated
- gene: GDB1
  text: SGD (phosphorylated in mitochondria) and the automated text (located in mitochondrion) imply a
    mitochondrial pool; the review treats this as a proteome detection without targeting signal and describes
    Gdb1 as cytosolic.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: GLG1
  text: SGD (vacuole, cell periphery) and the automated text (vacuole) give locations that the review
    rejects; it treats the vacuole term as a propagation from Komagataella glycophagy and places Glg1
    in the cytosol.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: GLK1
  text: Glucose import across the plasma membrane and plasma membrane location (automated) and the glucose
    uptake claim (UniProt) are marked as over-annotated in the review, which places Glk1 in the cytosol.
  sources:
  - UniProt
  - Alliance_Automated
- gene: GND1
  text: The automated text locates Gnd1 in the mitochondrion; the review marks this as over-annotated
    and places the enzyme in the cytosol.
  sources:
  - Alliance_Automated
- gene: GND2
  text: The automated text places Gnd2 at the plasma membrane; the review marks this as over-annotated
    and places the enzyme in the cytosol.
  sources:
  - Alliance_Automated
- gene: GPM3
  text: The automated text gives predicted phosphoglycerate mutase activity and glycolysis; SGD and the
    review state Gpm3 has no detectable mutase activity and no growth phenotype.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: GRX1
  text: The automated text gives only glutathione peroxidase and transferase activities plus protein glutathionylation;
    the review's core activity is glutathione disulfide oxidoreductase and it marks glutathionylation
    as over-annotated.
  sources:
  - Alliance_Automated
- gene: GSY1
  text: The automated text places Gsy1 in the mitochondrion; the review marks this as over-annotated and
    places Gsy1 in the cytosol and glycogen granule.
  sources:
  - Alliance_Automated
- gene: GTT2
  text: SGD's text says Gtt2 overlaps functionally with Gtt2p, a self-reference; the review and the GTT1
    SGD text indicate the partner is Gtt1.
  sources:
  - Alliance_Imported
- gene: GTT3
  text: SGD places Gtt3 fusion proteins at the cell periphery; the automated text and the review place
    it at the nuclear periphery/nuclear envelope.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: HFA1
  text: The automated text leads with long-chain fatty acid biosynthesis, which the review marks as over-annotated
    (rescue by an engineered cytosolic form); the native product feeds lipoic acid synthesis.
  sources:
  - Alliance_Automated
- gene: HFD1
  text: The automated text names carboxylate reductase activity; the review modifies this to NAD+-dependent
    long-chain fatty aldehyde dehydrogenase activity.
  sources:
  - Alliance_Automated
- gene: HKR1
  text: UniProt describes Hkr1 as a filamentous-growth signalling mucin and does not mention HOG osmosensing;
    SGD and GOA make it a Sho1-branch osmosensor redundant with Msb2. There is no HKR1 gene review yet
    to adjudicate.
  sources:
  - UniProt
  - Alliance_Imported
- gene: HMG2
  text: The automated text places Hmg2 in the proteasome complex; the review removes that annotation because
    Hmg2 is an ERAD substrate.
  sources:
  - Alliance_Automated
- gene: HSC82
  text: The automated text locates Hsc82 in the mitochondrion and plasma membrane; the review marks both
    as over-annotations of a cytosolic chaperone.
  sources:
  - Alliance_Automated
- gene: HXK1
  text: The automated text gives hexose import across the plasma membrane and a mitochondrial location;
    the review removes or marks the import terms as over-annotations and treats mitochondria as a minor
    pool.
  sources:
  - Alliance_Automated
- gene: HXK2
  text: SGD presents Hxk2 as a nuclear-shuttling repressor; the review cites live-cell imaging and RNA-seq
    showing negligible direct transcriptional activity and leaves the transcription annotation undecided.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: IDI1
  text: UniProt says the second ergosterol module is carried out in the vacuole; the review and the automated
    text place Idi1 in the cytosol.
  sources:
  - UniProt
  - Alliance_Automated
- gene: IDP3
  text: UniProt says IDP3 may supply NADPH for fatty acid and sterol synthesis; the review and SGD tie
    it to beta-oxidation of unsaturated fatty acids in peroxisomes.
  sources:
  - UniProt
  - Alliance_Imported
- gene: IMD2
  text: The automated text gives chromatin binding as the only function and omits IMP dehydrogenase activity,
    the core function in the review.
  sources:
  - Alliance_Automated
- gene: IMD3
  text: The automated text omits IMP dehydrogenase activity and names only identical protein binding.
  sources:
  - Alliance_Automated
- gene: IMD4
  text: The automated text gives mRNA binding as the only function and omits IMP dehydrogenase activity.
  sources:
  - Alliance_Automated
- gene: IPK1
  text: The automated text names nuclear-transcribed mRNA catabolism by non-stop decay, which the review
    marks as over-annotated.
  sources:
  - Alliance_Automated
- gene: IRC24
  text: SGD calls IRC24 a putative paralog of IRC24 itself; the review names the adjacent gene NRE1 as
    the paralog.
  sources:
  - Alliance_Imported
- gene: JIP4
  text: The automated text's spliceosome terms are marked over-annotated in the review, which treats function
    as unknown.
  sources:
  - Alliance_Automated
- gene: KDX1
  text: All three texts call Kdx1 a kinase; the review treats it as a pseudokinase (DFG to DFN, no TEY)
    acting non-catalytically with Swi4.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: KDX1
  text: The automated text's CDK activity, CDK holoenzyme and G2/M transition terms are removed in the
    review.
  sources:
  - Alliance_Automated
- gene: KGD4
  text: The automated text's ribosomal constituent activity and mitochondrial ribosome location are removed
    in the review, which treats the MRPS36 assignment as co-sedimentation with KGDH.
  sources:
  - Alliance_Automated
- gene: KTI11
  text: 'The automated text gives Kti11 the 2-(3-amino-3-carboxypropyl)histidine synthase activity, which
    the review marks as over-annotated: Kti11 donates electrons to Dph1-Dph2.'
  sources:
  - Alliance_Automated
- gene: LEE1
  text: The automated text's ubiquitin ligase activity and protein ubiquitination are marked over-annotated
    in the review, which accepts only zinc binding.
  sources:
  - Alliance_Automated
- gene: LEU2
  text: The automated text lists the glyoxylate cycle, which the review removes.
  sources:
  - Alliance_Automated
- gene: LOA1
  text: UniProt's vacuolar protein sorting role is marked over-annotated in the review (protein targeting
    to vacuole).
  sources:
  - UniProt
- gene: LPD1
  text: The automated text gives Lpd1 glycine dehydrogenase (decarboxylating) and oxoglutarate dehydrogenase
    activities, which belong to Gcv2 and Kgd1; the review modifies them.
  sources:
  - Alliance_Automated
- gene: LPP1
  text: UniProt gives substrate preference PA > DGPP > LPA; the review quotes PA > lyso-PA > DGPP from
    the primary paper.
  sources:
  - UniProt
- gene: LPX2
  text: SGD calls Lpx2 a lipase; the review notes the name rests on a lipidomic phenotype and a reported
    activity, with no hydrolase domain and no direct assay.
  sources:
  - Alliance_Imported
- gene: LYS4
  text: SGD has Lys4 converting homocitrate to homoisocitrate; the review says Lys4 only hydrates cis-homoaconitate
    and the homocitrate dehydration is done by Aco2.
  sources:
  - Alliance_Imported
- gene: MAD2
  text: The automated text leads with double-strand break repair via break-induced replication and microtubule
    cytoskeleton, both marked over-annotated in the review.
  sources:
  - Alliance_Automated
- gene: MAL33
  text: UniProt states MAL33 regulates the MAL3 maltase and permease genes; SGD and the review say the
    S288C allele is a non-functional activator.
  sources:
  - UniProt
  - Alliance_Imported
- gene: MBP1
  text: The automated text lists 'maintenance of translational fidelity', which the review removes.
  sources:
  - Alliance_Automated
- gene: MCR1
  text: SGD and the automated text name ergosterol biosynthesis; the review says the in vivo link is unresolved
    given the ER paralog Cbr1.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: MCT1
  text: SGD gives phospholipid remodeling as the mtFAS output; the review names octanoyl-ACP for lipoic
    acid synthesis and does not mention phospholipid remodeling.
  sources:
  - Alliance_Imported
- gene: MDH3
  text: SGD links MDH3 to the glyoxylate cycle; the automated text and the review place it in fatty acid
    beta-oxidation NADH reoxidation, with only mild acetate growth defects.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: MDM12
  text: SGD describes Mdm12 as a mitochondrial outer membrane protein; the review describes it as a soluble
    SMP-domain subunit held at contacts by Mmm1 and Mdm34.
  sources:
  - Alliance_Imported
- gene: MIM1
  text: SGD and the automated text describe Mim1-Mim2 as a channel; the review marks voltage-gated channel
    activity as over-annotated.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: MMM1
  text: SGD says Mmm1 localizes to the peroxisome in glucose; the review marks the peroxisome annotation
    as over-annotated.
  sources:
  - Alliance_Imported
- gene: MNT4
  text: The automated text predicts a role in protein O-linked glycosylation; SGD says MNT4 is not required
    for it, and the review marks the term over-annotated.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: MOH1
  text: UniProt gives a pro-apoptotic DNA damage role, while the review notes that moh1 deletion increases
    resistance to MMS and other stresses and calls the apoptosis interpretation uncertain.
  sources:
  - UniProt
- gene: MRX20
  text: The automated text predicts citrate transport; the review calls MRX20 a carrier of unknown substrate
    in a fungal-specific subfamily.
  sources:
  - Alliance_Automated
- gene: MSC2
  text: UniProt says Msc2 moves zinc from the nucleus/ER to the cytoplasm; SGD and the review say the
    Msc2-Zrg17 complex imports cytosolic zinc into the ER lumen.
  sources:
  - UniProt
  - Alliance_Imported
- gene: MVD1
  text: UniProt places the second module of ergosterol synthesis in the vacuole; the review describes
    Mvd1 as a soluble cytosolic enzyme and removes the vacuole annotation.
  sources:
  - UniProt
- gene: NCL1
  text: UniProt suggests a ribosome-biogenesis role from paromomycin sensitivity; the review removes the
    rRNA methyltransferase and rRNA processing rows and attributes 25S rRNA m5C to Rcm1 and Nop2.
  sources:
  - UniProt
- gene: NDE1
  text: The automated text lists pyruvate fermentation to ethanol, which the review marks as over-annotated.
  sources:
  - Alliance_Automated
- gene: NDI1
  text: SGD and the automated text give a pro-apoptotic role (positive regulation of apoptotic process);
    the review marks that row as over-annotated and treats death as a consequence of overexpression and
    ROS.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: NDL1
  text: The automated text gives microtubule plus-end binding as the function; the review marks it as
    over-annotated and uses dynein intermediate chain binding and motor regulator activity instead.
  sources:
  - Alliance_Automated
- gene: NQM1
  text: SGD describes Nqm1 as a transaldolase of unknown function; the review cites crystal structure
    and assays showing an active transaldolase, minor relative to Tal1.
  sources:
  - Alliance_Imported
- gene: NTE1
  text: The automated text locates Nte1 to lipid droplets; the review removes that annotation.
  sources:
  - Alliance_Automated
- gene: NVJ3
  text: The automated text predicts phosphatidylinositol-3-phosphate binding, which the review marks as
    over-annotated because Nvj3 lacks Mdm1's PX domain.
  sources:
  - Alliance_Automated
- gene: OAR1
  text: SGD says human CBR4 complements the oar1 null; the review states rescue requires co-expression
    of both CBR4 and HSD17B8.
  sources:
  - Alliance_Imported
- gene: OCA6
  text: The automated text predicts phosphatase activity; the review removes it because Oca6 lacks the
    invariant CX5R arginine and is likely a pseudophosphatase.
  sources:
  - Alliance_Automated
- gene: OLE1
  text: SGD and the automated text list mitochondrial inheritance as an Ole1 role; the review marks it
    as over-annotated, an indirect phenotype of UFA shortage.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: PAA1
  text: The automated text lists chromatin organization; the review marks it as over-annotated.
  sources:
  - Alliance_Automated
- gene: PAH1
  text: The automated text lists transcription cis-regulatory region binding; the review marks it as over-annotated.
  sources:
  - Alliance_Automated
- gene: PBS2
  text: The automated text gives Pbs2 protein N-terminal acetyltransferase activity and NatB membership;
    the review holds these UNDECIDED as a likely NAT3 mis-attribution.
  sources:
  - Alliance_Automated
- gene: PDC1
  text: UniProt lists phenylpyruvate as a preferred substrate for all three PDCs; the review keeps phenylpyruvate
    decarboxylase UNDECIDED for Pdc1 and finds it only for Pdc5.
  sources:
  - UniProt
- gene: PDC6
  text: UniProt and the automated text attribute phenylalanine-derived substrate use to Pdc6; the review
    says it shows no detectable phenylpyruvate decarboxylase activity.
  sources:
  - UniProt
  - Alliance_Automated
- gene: PDI1
  text: The automated text names PDIA3 as ortholog; the review says the closest human counterpart is PDIA1/P4HB.
  sources:
  - Alliance_Automated
- gene: PFK1
  text: SGD and the automated text say Pfk1 associates with or binds ribosomes; the review removes ribosome
    binding because the cited paper concludes Pfk1 is not directly associated with translating ribosomes,
    unlike Pfk2.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: PGI1
  text: The automated text lists mitochondrion as the only location; the review treats this as a minor
    pool of a cytosolic enzyme.
  sources:
  - Alliance_Automated
- gene: PHS1
  text: SGD and the automated text include a protein trafficking / vacuolar transport role that the review
    marks as over-annotated (from a promoter-shutoff screen).
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: PNO1
  text: The automated text lists proteasome assembly, which the review marks as over-annotated.
  sources:
  - Alliance_Automated
- gene: PNP1
  text: The automated text states inosine nucleosidase and nicotinamide riboside hydrolase activities;
    the review modifies both, as Pnp1 cleaves these substrates by phosphorolysis.
  sources:
  - Alliance_Automated
- gene: POF1
  text: SGD and the automated text give Pof1 ATPase activity in protein quality control; the review marks
    ATP hydrolysis activity and ERAD as over-annotated.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: PPH21
  text: UniProt states the exact function of Pph21 is not known; the review describes its mitotic and
    TORC1-pathway roles in detail.
  sources:
  - UniProt
- gene: PSD2
  text: SGD places Psd2 in Golgi and vacuolar membranes; the review assigns it to the cytoplasmic face
    of endosomes, noting the early fraction only resembled Golgi and vacuoles.
  sources:
  - Alliance_Imported
- gene: PTA1
  text: All three sources name pre-tRNA processing as a Pta1 function; the review marks it over-annotated
    as a probably indirect phenotype.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: PYK2
  text: The automated text gives melatonin binding and mitochondrion; the review marks melatonin binding
    over-annotated and treats Pyk2 as cytosolic.
  sources:
  - Alliance_Automated
- gene: RAS2
  text: The automated text lists protein localization to bud neck and positive regulation of transcription
    by galactose; the review removes the first and leaves the second undecided.
  sources:
  - Alliance_Automated
- gene: RIB2
  text: UniProt gives Rib2 the ribosyl substrate DARPP, which places deamination before reduction; the
    review and RIB7 entry put Rib7 reduction first, as in other fungi.
  sources:
  - UniProt
- gene: RIB7
  text: SGD calls Rib7 a diaminohydroxyphosphoribosylaminopyrimidine deaminase; the review, UniProt and
    the automated text identify it as the DAROPP reductase, with Rib2 as the deaminase.
  sources:
  - Alliance_Imported
- gene: RLF2
  text: The automated text places Rlf2 in the nucleosome; the review removes that annotation, as CAF-1
    is a chaperone and not a nucleosome component.
  sources:
  - Alliance_Automated
- gene: RNR1
  text: SGD says the nuclear share of Rnr1 rises under replication stress; the review marks the HDA nucleus
    annotation as over-annotated and states Rnr1 stays cytoplasmic while the small subunits relocate.
  sources:
  - Alliance_Imported
- gene: ROF1
  text: The automated text says positive regulation of Pol II transcription; the review modifies this
    to regulation, since overexpression represses the FLO11 regulon.
  sources:
  - Alliance_Automated
- gene: SAN1
  text: UniProt still describes San1 as a regulator of SIR4 stability in mating-type control; the other
    sources and the review describe a nuclear quality-control E3 ligase.
  sources:
  - UniProt
  - Alliance_Imported
- gene: SAS3
  text: The automated text says Sas3 is involved in subtelomeric heterochromatin formation; the review
    removes that annotation.
  sources:
  - Alliance_Automated
- gene: SCS7
  text: The automated text gives Scs7 sphingolipid C4-monooxygenase activity; the review assigns C-4 hydroxylation
    to Sur2 and modifies the annotation.
  sources:
  - Alliance_Automated
- gene: SER3
  text: The automated text gives only the (R)-2-hydroxyglutarate dehydrogenase activity; the review's
    core activity is phosphoglycerate dehydrogenase.
  sources:
  - Alliance_Automated
- gene: SER33
  text: The automated text omits phosphoglycerate dehydrogenase, the core activity, and names only (R)-2-hydroxyglutarate
    dehydrogenase.
  sources:
  - Alliance_Automated
- gene: SIA1
  text: The automated text places Sia1 in proton transmembrane transport; the review modifies this to
    regulation of proton transport, as Sia1 acts on Pma1 activation.
  sources:
  - Alliance_Automated
- gene: SKP1
  text: The automated text leads with DNA replication origin binding, which the review marks as over-annotated;
    Skp1 is a non-catalytic adaptor and does not bind DNA itself.
  sources:
  - Alliance_Automated
- gene: SMX2
  text: The automated text lists 7-methylguanosine cap hypermethylation as a process; the review marks
    it as over-annotated.
  sources:
  - Alliance_Automated
- gene: SNO1
  text: The automated text includes negative regulation of apoptotic process, which the review marks as
    over-annotated.
  sources:
  - Alliance_Automated
- gene: SNO2
  text: SGD says Sno2 is of unknown function, while UniProt states glutaminase activity as fact. The review
    accepts the family-based glutaminase role but notes it has not been shown biochemically for SNO2.
  sources:
  - Alliance_Imported
  - UniProt
- gene: SOL3
  text: SGD calls Sol3 a weak multicopy suppressor of los1-1, while the review quotes PMID:15454531 that
    Sol3 and Sol4 have little or no detectable effect on los1 suppression.
  sources:
  - Alliance_Imported
- gene: SPH1
  text: The automated text gives MAP kinase scaffold activity, which the review marks as over-annotated;
    Sph1 has only two-hybrid binding to the MAPKKs.
  sources:
  - Alliance_Automated
- gene: SPS19
  text: The automated text lists ascospore formation, which the review marks as over-annotated; SPS19
    is dispensable for sporulation on acetate.
  sources:
  - Alliance_Automated
- gene: SRP40
  text: 'UniProt''s ''Not known'' is dated: the review adds ribosome biogenesis as NEW on the basis of
    the nucleolar Nopp140-like role that SGD describes.'
  sources:
  - UniProt
  - Alliance_Imported
- gene: SSB1
  text: The automated text does not mention cotranslational folding, the core function in the review and
    in UniProt and SGD.
  sources:
  - Alliance_Automated
- gene: STR2
  text: UniProt names O-succinyl-L-homoserine as the substrate; the review says yeast makes O-acetyl-L-homoserine
    (via Met2) and flags that GO:0003962 is defined with the succinyl form.
  sources:
  - UniProt
- gene: TDA5
  text: 'All three texts predate the DHRSX-ortholog finding: tda5 mutants accumulate polyprenol and lack
    dolichol, rescued by human DHRSX. SGD still calls it a protein of unknown function.'
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: TDH1
  text: The automated text asserts melatonin binding, which the review marks over-annotated as resting
    on weak affinity capture.
  sources:
  - Alliance_Automated
- gene: TDH2
  text: Melatonin binding and promoter-specific chromatin binding in the automated text are both marked
    over-annotated in the review.
  sources:
  - Alliance_Automated
- gene: THI22
  text: The automated text places THI22 in thiamine biosynthesis with HMP/HMP-P kinase activity. UniProt,
    SGD and the review say it is dispensable and has no demonstrated activity.
  sources:
  - Alliance_Automated
  - UniProt
  - Alliance_Imported
- gene: THI3
  text: UniProt and the automated text assert branched-chain 2-oxo acid decarboxylase activity. SGD and
    the review (REMOVE, citing direct assays) say no decarboxylase activity is detected.
  sources:
  - UniProt
  - Alliance_Automated
  - Alliance_Imported
- gene: TPS1
  text: The automated text gives Tps1 trehalose-phosphatase activity, which the review marks over-annotated;
    the phosphatase is Tps2.
  sources:
  - Alliance_Automated
- gene: UBC9
  text: UniProt and SGD say Ubc9 is needed for S- and M-phase cyclin degradation. The review explains
    that this came from the 1995 view of Ubc9 as a ubiquitin E2 and that the G2/M arrest reflects loss
    of sumoylation.
  sources:
  - UniProt
  - Alliance_Imported
- gene: UBP3
  text: The automated text lists mRNA binding as an enabled activity; the review marks both mRNA binding
    rows over-annotated (presence in mRNP complexes, not direct binding).
  sources:
  - Alliance_Automated
- gene: UTR4
  text: SGD and the automated text describe the activity as similarity-based or predicted, while the review
    treats Utr4 as the genetically established enolase-phosphatase (YNL010W not involved).
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: VIP1
  text: UniProt's microtubule dynamics, Mal3 and growth-zone selection claims come from S. pombe Asp1
    by similarity; the review states there is no targeted S. cerevisiae evidence for these.
  sources:
  - UniProt
- gene: VMA22
  text: The automated text gives nucleus as the sole location, while SGD and the review place Vma22 on
    the ER.
  sources:
  - Alliance_Automated
  - Alliance_Imported
- gene: WHI5
  text: SGD calls Whi5 a 'functional Rb homolog'; the review says it is a functional analog, not a homolog,
    of Rb.
  sources:
  - Alliance_Imported
- gene: WSS1
  text: SGD and the automated text present SUMO ligase activity as a main function; the review keeps it
    non-core as a single-lab, unreproduced finding.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: YAT1
  text: SGD says outer mitochondrial membrane; the review notes UniProt places Yat1 peripheral to the
    inner membrane, so the sub-compartment is unresolved.
  sources:
  - Alliance_Imported
- gene: YAT1
  text: The automated text lists carnitine O-palmitoyltransferase activity, which the review modifies
    to acetyltransferase.
  sources:
  - Alliance_Automated
- gene: YDC1
  text: UniProt names Ydc1 an acyl-CoA-independent ceramide synthase while describing hydrolysis; SGD
    and the review treat it as a dihydroceramidase with minor reverse activity.
  sources:
  - UniProt
- gene: ZDS2
  text: UniProt omits the PP2A-Cdc55 binding that the review treats as the core mechanism and instead
    stresses Cdc42/Pkc1/Bcy1 links.
  sources:
  - UniProt
gap:
- gene: ABZ1
  text: SGD names PABA as a precursor of ubiquinone (coenzyme Q); the review mentions only folate.
  sources:
  - Alliance_Imported
- gene: ACC1
  text: SGD's histone acetylation regulation and uORF-dependent translational control, and UniProt's Vac8
    acylation role, are not covered in the review.
  sources:
  - Alliance_Imported
  - UniProt
- gene: ACH1
  text: SGD says Ach1 is required for diploid pseudohyphal growth; the review does not mention it.
  sources:
  - Alliance_Imported
- gene: ACS1
  text: SGD describes metabolite-induced Acs1p filaments in meiotic cells; the review does not mention
    them.
  sources:
  - Alliance_Imported
- gene: ADH2
  text: SGD's ADR1 regulation and carboxylate ester production are not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: ADH4
  text: UniProt calls Adh4 mainly a mitochondrial formaldehyde dehydrogenase; the review does not assess
    this.
  sources:
  - UniProt
- gene: ADI1
  text: SGD's polycistronic transcription with YMR010W and Rnt1 cleavage are not in the review.
  sources:
  - Alliance_Imported
- gene: AHP1
  text: UniProt cites a role in Mn2+ homeostasis (PMID:10635552); the review mentions only metal sensitivity.
  sources:
  - UniProt
- gene: ALD4
  text: SGD says Ald4p polymerises into filaments in meiotic cells; the review does not mention it.
  sources:
  - Alliance_Imported
- gene: ALD6
  text: SGD calls Ald6p a negative regulator of nonselective autophagy; the review does not mention autophagy.
  sources:
  - Alliance_Imported
- gene: ALO1
  text: SGD reports that the alo1 null improves amber (TAG) noncanonical amino acid incorporation; the
    review does not mention this.
  sources:
  - Alliance_Imported
- gene: ALT1
  text: SGD's TOR1-independent chronological lifespan role and Nrg1-mediated repression appear nowhere
    in the ALT1 review or notes.
  sources:
  - Alliance_Imported
- gene: ARO10
  text: SGD says ARO10 is involved in protein N-terminal Met and Ala catabolism; the ARO10 review does
    not address this.
  sources:
  - Alliance_Imported
- gene: ARO8
  text: SGD names ARO8, with ARO9, in kynurenic acid production to detoxify excess tryptophan; the ARO8
    review does not mention kynurenine or kynurenic acid.
  sources:
  - Alliance_Imported
- gene: ASP1
  text: SGD calls Asp1 important for acute lymphoblastic leukemia treatment; the ASP1 review does not
    discuss any therapeutic use.
  sources:
  - Alliance_Imported
- gene: ASP3-1
  text: SGD's internal short ncRNA that enhances ASP3 expression, and the antitumor activity, are not
    mentioned in the ASP3-1 review.
  sources:
  - Alliance_Imported
- gene: ATG1
  text: UniProt's glycogen storage in stationary phase and filamentous growth roles are not in the ATG1
    review.
  sources:
  - UniProt
- gene: ATG7
  text: SGD's role in methionine-restriction extension of chronological lifespan is not covered by the
    ATG7 review.
  sources:
  - Alliance_Imported
- gene: AYR1
  text: UniProt's TAG-lipolysis requirement for starvation-induced autophagy and the cell wall role, and
    SGD's steroid hormone metabolism, are not in the AYR1 review.
  sources:
  - UniProt
  - Alliance_Imported
- gene: BCY1
  text: SGD calls Bcy1 a regulator of meiotic commitment; the BCY1 review mentions neither meiosis nor
    sporulation.
  sources:
  - Alliance_Imported
- gene: BNA1
  text: SGD says BNA1 expression is regulated by Hst1p; the review and notes do not mention Hst1 regulation
    (the same claim appears for BNA4, BNA5, BNA6 and BNA2).
  sources:
  - Alliance_Imported
- gene: BNA2
  text: The telomere uncapping response (CDC13 genetic interaction) and the overexpression lifespan and
    lipid-droplet phenotype appear nowhere in the BNA2 review or notes.
  sources:
  - UniProt
  - Alliance_Imported
- gene: BUB3
  text: SGD says Bub3 functions at the kinetochore to activate APC/C-Cdc20 for normal mitotic progression;
    the review covers only the inhibitory MCC role.
  sources:
  - Alliance_Imported
- gene: CAB4
  text: SGD says Cab4 (and Cab5) is involved in histone acylation; neither review mentions it.
  sources:
  - Alliance_Imported
- gene: CAR1
  text: SGD says CAR1 disruption lowers ethyl carbamate in wine fermentation and enhances freeze tolerance;
    the review does not cover either.
  sources:
  - Alliance_Imported
- gene: CDC14
  text: SGD says Cdc14 downregulates microautophagy induction after TORC1 inactivation; the review covers
    only Atg13 dephosphorylation that stimulates autophagy.
  sources:
  - Alliance_Imported
- gene: CHS1
  text: SGD says CHS1 transcription is activated by mating factor; the review does not mention pheromone
    induction.
  sources:
  - Alliance_Imported
- gene: CIT1
  text: SGD states CIT1 transcription is subject to glucose repression; the review does not discuss CIT1
    regulation by carbon source.
  sources:
  - Alliance_Imported
- gene: CIT2
  text: SGD names Rtg1/Rtg2 (retrograde) control of CIT2 expression; the review does not mention the RTG
    pathway.
  sources:
  - Alliance_Imported
- gene: CLN3
  text: SGD says acetyl-CoA induces CLN3 transcription on nutrient repletion; the review mentions nutrient
    effects on Cln3 but not acetyl-CoA.
  sources:
  - Alliance_Imported
- gene: CPT1
  text: SGD says CPT1 is required for inositol-dependent regulation of EPT1 transcription; the review
    does not mention this.
  sources:
  - Alliance_Imported
- gene: CRD1
  text: SGD says Crd1 is needed for tubular mitochondrial morphology, mitochondrial fusion and outer membrane
    integration of multispanning proteins; the review does not discuss these.
  sources:
  - Alliance_Imported
- gene: DGA1
  text: UniProt says Dga1 is involved in ergosterol biosynthesis. The review does not mention ergosterol.
  sources:
  - UniProt
- gene: DIE2
  text: SGD says DIE2 has a role in regulating ITR1 and INO1. The review does not cover this.
  sources:
  - Alliance_Imported
- gene: DNM1
  text: SGD says Dnm1 is involved in endocytosis. The review does not mention endocytosis.
  sources:
  - Alliance_Imported
- gene: DTD1
  text: SGD says DTD1 may affect nonsense suppression. The review does not mention nonsense suppression.
  sources:
  - Alliance_Imported
- gene: ELO3
  text: UniProt says ELO3 may act in a glucose-signaling pathway controlling PMA1, HXT3 and SNF3. The
    review mentions only the Pma1 phenotype, not glucose signaling.
  sources:
  - UniProt
- gene: ENO2
  text: SGD says ENO2 mRNA is asymmetrically distributed to daughter cells in a Sir2-dependent manner.
    The review does not cover this.
  sources:
  - Alliance_Imported
- gene: ERG1
  text: SGD says Erg1 is targeted to the ER by the GET pathway and degraded by ERAD triggered by membrane
    lipid saturation. The review covers neither.
  sources:
  - Alliance_Imported
- gene: ERG3
  text: SGD states erg3 mutants cannot grow on non-fermentable carbon sources; the review does not mention
    a respiratory growth defect.
  sources:
  - Alliance_Imported
- gene: FAA2
  text: SGD suggests a mitochondrially targeted Faa2 form from an upstream non-canonical start codon;
    the review does not mention it.
  sources:
  - Alliance_Imported
- gene: FAS1
  text: SGD names allosteric inhibition of ketoacyl reductase by palmitoyl-CoA and the antifungal NPD6433
    as a specific target; neither appears in the FAS1 or FAS2 review.
  sources:
  - Alliance_Imported
- gene: FIG4
  text: SGD states Fig4 is required for efficient mating; the review does not mention mating.
  sources:
  - Alliance_Imported
- gene: FUM1
  text: SGD states Fum1 is phosphorylated in mitochondria; the review does not mention phosphorylation.
  sources:
  - Alliance_Imported
- gene: FUS3
  text: SGD lists Bni1 and Sst2 as Fus3 substrates; the review does not mention either.
  sources:
  - Alliance_Imported
- gene: GAL10
  text: The UniProt FUNCTION text omits the N-terminal UDP-glucose 4-epimerase activity that SGD, the
    automated text and the review treat as core.
  sources:
  - UniProt
- gene: GAL7
  text: SGD says human UGP2 complements the gal7 null; the review names only GALT as the human counterpart
    and does not cover this complementation.
  sources:
  - Alliance_Imported
- gene: GDH2
  text: SGD states GDH2 genetically interacts with GDH3 in suppressing stress-induced apoptosis; the review
    does not mention this.
  sources:
  - Alliance_Imported
- gene: GEP4
  text: SGD's tunicamycin and DTT sensitivity of the null mutant is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: GLN1
  text: SGD's pH-dependent filament formation as an inactive storage form during starvation is not mentioned
    in the review.
  sources:
  - Alliance_Imported
- gene: GLO1
  text: SGD says Glo1 is required for full activity of Met17 (O-acetyl homoserine sulfhydrylase); the
    review does not mention this.
  sources:
  - Alliance_Imported
- gene: GLR1
  text: SGD's claims that cytosolic Glr1 sets the redox state of the mitochondrial intermembrane space
    and that mitochondrial Glr1 confers hyperoxia resistance are not in the review.
  sources:
  - Alliance_Imported
- gene: GNA1
  text: SGD says Gna1 is required for passage through START, DNA synthesis and mitosis; the review describes
    only the lethal morphology of the null and no cell-cycle roles.
  sources:
  - Alliance_Imported
- gene: GPD1
  text: SGD's inactivation of Gpd1 by Ypk1/Ypk2 phosphorylation is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: GPD2
  text: SGD's inactivation of Gpd2 by SNF1 phosphorylation is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: GPH1
  text: SGD's regulation by cAMP-mediated phosphorylation, Cdc28 phosphorylation and HOG-pathway expression
    control is not in the review, which mentions only Thr31 activation.
  sources:
  - Alliance_Imported
- gene: GPX1
  text: SGD's claim that Gpx1 glutathione peroxidase activity is neuroprotective in Huntington's disease
    models is not in the review.
  sources:
  - Alliance_Imported
- gene: GPX1
  text: SGD omits the peroxisomal matrix location and peroxisome formation role that UniProt, the automated
    text and the review include.
  sources:
  - Alliance_Imported
- gene: GPX2
  text: SGD's late-acting antioxidant role decreasing mitochondrial ROS production and preserving electron
    transport chain function is not covered in the review.
  sources:
  - Alliance_Imported
- gene: GRX2
  text: UniProt's S-glutathionylation of DHBP synthase by Grx2 is not mentioned in the review.
  sources:
  - UniProt
- gene: GUK1
  text: SGD says GUK1 is required for mannose outer chain elongation of cell wall N-linked glycoproteins;
    the review does not mention this.
  sources:
  - Alliance_Imported
- gene: GUT1
  text: SGD's regulators of GUT1 expression (Ino2-Ino4, Opi1, Rsf1) are not mentioned in the review, which
    names only Adr1.
  sources:
  - Alliance_Imported
- gene: GUT2
  text: SGD's regulators of GUT2 expression (cAMP, Snf1, Rsf1, Hap2/3/4/5) are not in the review.
  sources:
  - Alliance_Imported
- gene: HAC1
  text: SGD's role for Hac1 in UPR-mediated suppression of aneuploidy is not in the review.
  sources:
  - Alliance_Imported
- gene: HEM1
  text: SGD's Mcx1-mediated PLP insertion and Hap2-Hap3 regulation of HEM1 expression are not in the review.
  sources:
  - Alliance_Imported
- gene: HIS1
  text: SGD's sensitivity to Cu, Co and Ni salts is not covered in the HIS1 review; the same phrase appears
    in the HIS2, HIS3, HIS5 and HIS6 SGD texts.
  sources:
  - Alliance_Imported
- gene: HIS2
  text: The Cu, Co and Ni salt sensitivity named by SGD is not covered in the review.
  sources:
  - Alliance_Imported
- gene: HIS3
  text: The Cu, Co and Ni salt sensitivity named by SGD is not covered in the review.
  sources:
  - Alliance_Imported
- gene: HIS5
  text: The Cu, Co and Ni salt sensitivity named by SGD is not covered in the review.
  sources:
  - Alliance_Imported
- gene: HIS6
  text: The Cu, Co and Ni salt sensitivity named by SGD is not covered in the review.
  sources:
  - Alliance_Imported
- gene: HMG2
  text: Neither UniProt nor SGD mentions the sterol-regulated ER-associated degradation of Hmg2 and its
    control by Nsg1, which the review treats as its distinguishing biology.
  sources:
  - UniProt
  - Alliance_Imported
- gene: HOG1
  text: UniProt's arsenic sensor role (direct arsenic binding and Arr1 phosphorylation) and Mnn1 Golgi
    localization are not covered in the review.
  sources:
  - UniProt
- gene: HOG1
  text: SGD's repression of pseudohyphal growth by nuclear Hog1 is not covered in the review.
  sources:
  - Alliance_Imported
- gene: HSF1
  text: SGD's condensate formation with Mediator and Pol II, RQC-mediated translation-stress sensing and
    activation by intracellular acidification are not covered in the review.
  sources:
  - Alliance_Imported
- gene: HSP78
  text: UniProt's requirement of Hsp78 for efficient Pim1-mediated degradation, and SGD's ethanol stress
    role, are not covered in the review.
  sources:
  - UniProt
  - Alliance_Imported
- gene: HXK2
  text: SGD's Sit4-dependent control of cell cycle, mitochondrial function and lifespan, and the Glc7-Reg1
    dephosphorylation, are not covered in the review.
  sources:
  - Alliance_Imported
- gene: HYR1
  text: SGD's claim that the glutathione peroxidase activity is neuroprotective in Huntington's disease
    models is not covered in the review.
  sources:
  - Alliance_Imported
- gene: IDH1
  text: No source states that Idh1 is the regulatory subunit that binds AMP and confers cooperativity,
    the core point of the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: IDH2
  text: SGD's AP-3 vacuolar targeting and UniProt's 5'-UTR RNA binding are not covered in the IDH2 review.
  sources:
  - Alliance_Imported
  - UniProt
- gene: INP51
  text: UniProt's essential role in a TGN-to-early endosome pathway and negative regulation of the Slm
    pathway are not covered in the review.
  sources:
  - UniProt
- gene: IPT1
  text: SGD's resistance of ipt1 mutants to syringomycin E and K. lactis zymocin is not mentioned in the
    review, which covers only DmAMP1 and Ca2+.
  sources:
  - Alliance_Imported
- gene: IRC24
  text: SGD's induction by MMS is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: ISC1
  text: SGD's Na+ and Li+ halotolerance role, and activation by cardiolipin and phosphatidylglycerol,
    are not covered in the review.
  sources:
  - Alliance_Imported
- gene: JJJ3
  text: SGD's role in targeting SRP-independent proteins to the ER is not covered anywhere in the review.
  sources:
  - Alliance_Imported
- gene: KCS1
  text: SGD's role in RNA polymerase I rRNA transcription and Snf1 phosphorylation of Kcs1 (filamentous
    and invasive growth) are not in the review.
  sources:
  - Alliance_Imported
- gene: KSS1
  text: SGD's note that KSS1 is nonfunctional in some S288C-related strains is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: LAC1
  text: UniProt's role for Lac1 and Lag1 in pheromone MAPK activation and Ste5 membrane localization is
    not covered in the review.
  sources:
  - UniProt
- gene: LAT1
  text: SGD's role as a metabolic longevity factor in calorie-restriction lifespan extension is not mentioned
    in the review.
  sources:
  - Alliance_Imported
- gene: LCB3
  text: UniProt's role for Lcb3 in endocytosis is not covered in the review.
  sources:
  - UniProt
- gene: LYS9
  text: SGD's genetic and physical interactions with TRM112 are not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: MCA1
  text: SGD names cell cycle dynamics, lifespan extension and a monomeric structure, none of which the
    review covers.
  sources:
  - Alliance_Imported
- gene: MCO14
  text: SGD reports MMS induction of MCO14, which the review does not mention.
  sources:
  - Alliance_Imported
- gene: MDE1
  text: SGD names Smt3 sumoylation and caspofungin downregulation and resistance, which the review does
    not mention.
  sources:
  - Alliance_Imported
- gene: MDM10
  text: SGD says ERMES is required for mitophagy; the MDM10, MDM12 and MDM34 reviews do not mention mitophagy.
  sources:
  - Alliance_Imported
- gene: MDM34
  text: SGD says Mdm34 may coordinate mtDNA replication and growth and co-localizes with pyruvate dehydrogenase;
    the review covers neither.
  sources:
  - Alliance_Imported
- gene: MET7
  text: UniProt says MET7 is involved in telomere maintenance; the review does not mention telomeres.
  sources:
  - UniProt
- gene: MIH1
  text: SGD says Mih1 acts in retrograde transport by modulating Vps26 phosphorylation; the review does
    not mention retromer.
  sources:
  - Alliance_Imported
- gene: MLS1
  text: SGD says Mls1 can use butyryl-CoA as acyl donor; the review does not mention it.
  sources:
  - Alliance_Imported
- gene: MON1
  text: SGD says Mon1 reaches the vacuole by the AP-3 pathway; the review does not mention AP-3.
  sources:
  - Alliance_Imported
- gene: MPS1
  text: SGD lists Mob1 as an Mps1 substrate and Mps1 as an APC/C(Cdh1) substrate; the review mentions
    neither.
  sources:
  - Alliance_Imported
- gene: MPS3
  text: UniProt says Mps3 recruits double-strand breaks to the nuclear periphery for chromosome healing;
    the review does not cover DSB relocation.
  sources:
  - UniProt
- gene: MRE11
  text: SGD says Mre11 associates with Ser/Thr-rich ORFs in premeiotic phase; the review does not mention
    it.
  sources:
  - Alliance_Imported
- gene: MSI1
  text: SGD lists kinetochore maintenance and repression of divergent noncoding transcription as CAF-1
    roles; the review does not cover them.
  sources:
  - Alliance_Imported
- gene: NCP1
  text: SGD says NCP1 is associated and coordinately regulated with Erg11p, and UniProt says it supplies
    heme oxygenase; neither point appears in the review.
  sources:
  - Alliance_Imported
  - UniProt
- gene: NDE1
  text: UniProt says NDE1 regulates the glycerol-3-phosphate dehydrogenase GUT2; the review does not mention
    GUT2.
  sources:
  - UniProt
- gene: NDE2
  text: UniProt says NDE2 regulates GUT2; the review does not mention GUT2.
  sources:
  - UniProt
- gene: NQM1
  text: SGD's regulators (Mot1 repression, alpha-factor and diauxic-shift induction) are not mentioned
    in the review, which cites glucose repression and Vhr1 instead.
  sources:
  - Alliance_Imported
- gene: NTH1
  text: SGD says Nth1 is phosphorylated and activated by Cdc28 at G1/S; the review covers PKA and 14-3-3
    activation but not Cdc28.
  sources:
  - Alliance_Imported
- gene: NTH2
  text: SGD's claim that NTH2 is required for thermotolerance is not covered by the review.
  sources:
  - Alliance_Imported
- gene: NUC1
  text: SGD lists maintenance of polyploidy among Nuc1 roles; the review does not cover it.
  sources:
  - Alliance_Imported
- gene: OCA6
  text: SGD's tunicamycin and DTT sensitivity of the null is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: ODC1
  text: SGD says multicopy ODC1 suppresses an fmc1 null mutation; the review does not mention FMC1.
  sources:
  - Alliance_Imported
- gene: PAP2
  text: UniProt says Trf4 is required for nuclear division, sister chromatid cohesion and chromosome condensation;
    the review does not cover these, and describes genome-integrity effects as indirect via RNA surveillance.
  sources:
  - UniProt
- gene: PAP2
  text: SGD says Pap2 relocalises to the cytosol under hypoxia; the review does not mention hypoxia.
  sources:
  - Alliance_Imported
- gene: PBS2
  text: SGD's role in Ty1 transposition is not covered by the review.
  sources:
  - Alliance_Imported
- gene: PCK1
  text: SGD names Mcm1 and Cat8 as regulators of PCK1; the review does not mention them.
  sources:
  - Alliance_Imported
- gene: PDC1
  text: SGD's post-translational regulation of Pdc1 (glucose-dependent phosphorylation, N-terminal propionylation,
    Tyr157/Tyr344 nitration) is not covered by the review.
  sources:
  - Alliance_Imported
- gene: PDX3
  text: SGD says PDX3 transcription is under general nitrogen control; the review does not mention it.
  sources:
  - Alliance_Imported
- gene: PET191
  text: UniProt says Pet191 stabilises an early assembly intermediate until displaced by Cox17; the review
    states its molecular role is not known and does not mention Cox17.
  sources:
  - UniProt
- gene: PGI1
  text: SGD says PGI1 is required for cell cycle progression; the review does not mention a cell cycle
    role.
  sources:
  - Alliance_Imported
- gene: PGK1
  text: UniProt's by-similarity claim that Pgk1 negatively regulates mitochondrial acetyl-CoA synthesis
    from pyruvate is not covered by the review.
  sources:
  - UniProt
- gene: PGM2
  text: SGD's 'protein abundance increases in response to DNA replication stress' is not covered by the
    review.
  sources:
  - Alliance_Imported
- gene: PHO91
  text: SGD says Pho91 acts upstream of Pho81 in the PHO pathway and is targeted to the vacuole by AP-3;
    neither claim is in the review.
  sources:
  - Alliance_Imported
- gene: PIK1
  text: UniProt's pheromone response and cytokinesis claims are not covered by the review.
  sources:
  - UniProt
  - Alliance_Imported
- gene: PIK1
  text: No source names the Golgi PtdIns4P requirement for secretory cargo exit or the Frq1 subunit, central
    in the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: PLC1
  text: SGD states that Plc1 and inositol polyphosphates are required for acetyl-CoA homeostasis and global
    histone acetylation; the review does not cover this.
  sources:
  - Alliance_Imported
- gene: POX1
  text: SGD says Pox1 is part of a light-sensing pathway making an H2O2 signal that modulates Msn2 nucleocytoplasmic
    shuttling; the review does not mention this.
  sources:
  - Alliance_Imported
- gene: PPH21
  text: SGD's claim that Tpd3 and Far11 of the PPG1-FAR complex antagonize TORC2 signalling is not covered
    by the review.
  sources:
  - Alliance_Imported
- gene: PRS1
  text: SGD says Prs1 plays a key role in the cell wall integrity pathway; the review notes only caffeine
    hypersensitivity linking PRPP to cell integrity.
  sources:
  - Alliance_Imported
- gene: PSA1
  text: UniProt's cell-size checkpoint claim is not in the review, which mentions only an SRB1 link to
    cell-cycle progression.
  sources:
  - UniProt
- gene: PSD1
  text: UniProt says Psd1 is required for mitophagy induction during nitrogen starvation; the review does
    not mention mitophagy.
  sources:
  - UniProt
- gene: PSD2
  text: SGD's claim that loss of Psd2 specifically reduces vacuolar membrane PE is not covered by the
    review.
  sources:
  - Alliance_Imported
- gene: PUT2
  text: SGD says human ALDH4A1 complements the put2 null mutant; the review does not mention this.
  sources:
  - Alliance_Imported
- gene: RAD27
  text: SGD lists large loop repair and ribonucleotide excision repair; neither appears in the review.
  sources:
  - Alliance_Imported
- gene: RLF2
  text: SGD names repression of divergent noncoding transcription, which the review does not cover.
  sources:
  - Alliance_Imported
- gene: RNR3
  text: None of the sources says RNR3 is the DNA-damage-inducible subunit (DIN1) with under 1% activity
    alone, the main point of the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: ROF1
  text: SGD's claim that overexpression causes a cell cycle delay or arrest is not covered in the review.
  sources:
  - Alliance_Imported
- gene: RPF2
  text: No source names the obligate Rpf2-Rrs1 heterodimer that recruits the 5S RNP, which is the core
    function in the review.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: RPL39
  text: SGD names a genetic interaction with SIS1 that the review does not cover; the PAB1 bypass is covered.
  sources:
  - Alliance_Imported
- gene: RRT2
  text: UniProt says RRT2 was found in a screen for reduced rDNA transcription; the review does not cover
    this.
  sources:
  - UniProt
- gene: RVS167
  text: SGD says Rvs167 is needed for trafficking of CoQ6 to mitochondria and has a role in exocytosis;
    the review covers neither.
  sources:
  - Alliance_Imported
- gene: SAM2
  text: SGD proposes a mitochondrially targeted Sam2 from an upstream non-canonical start codon; the review
    does not mention it.
  sources:
  - Alliance_Imported
- gene: SER1
  text: SGD says Ser1 abundance rises under DNA replication stress; the review does not mention this.
  sources:
  - Alliance_Imported
- gene: SFA1
  text: SGD says SFA1 is regulated by Hog1-Sko1 and that its abundance rises under replication stress;
    the review covers neither.
  sources:
  - Alliance_Imported
- gene: SIC1
  text: UniProt's claims that Sic1 matters for chromosome segregation and responds to a post-Start checkpoint
    signal appear nowhere in the review.
  sources:
  - UniProt
- gene: SIS2
  text: SGD calls Sis2 a dose-dependent regulator of replicative lifespan. The review does not mention
    lifespan.
  sources:
  - Alliance_Imported
- gene: SOD1
  text: SGD says MICOS modulates Sod1 localization to the mitochondrial intermembrane space. The review
    discusses IMS import via Ccs1 but not MICOS.
  sources:
  - Alliance_Imported
- gene: SPE1
  text: SGD reports that spe1 deletion shortens lifespan and increases necrotic death and ROS. The review
    does not mention these phenotypes.
  sources:
  - Alliance_Imported
- gene: SPE2
  text: UniProt names maintenance of a ds-RNA virus and SGD the oxygen-dependence of the polyamine requirement.
    Neither appears in the review.
  sources:
  - UniProt
  - Alliance_Imported
- gene: SPE3
  text: SGD says Spe3 is also involved in pantothenic acid biosynthesis (via spermine-derived beta-alanine).
    The review does not mention pantothenate.
  sources:
  - Alliance_Imported
- gene: SPE4
  text: SGD links Spe4 to pantothenic acid biosynthesis. The review does not cover this.
  sources:
  - Alliance_Imported
- gene: SSK1
  text: SGD says Ssk1 is required for mitophagy. The review does not mention mitophagy.
  sources:
  - Alliance_Imported
- gene: SSK2
  text: SGD says a HOG-independent Ssk2 function mediates the calcium sensitivity of the ptp2 msg5 double
    mutant. The review does not cover this.
  sources:
  - Alliance_Imported
- gene: SUS1
  text: SGD says Sus1 negatively regulates telomere length through H2BK123 monoubiquitination and the
    nuclear pore. The review does not mention telomeres.
  sources:
  - Alliance_Imported
- gene: SWE1
  text: SGD says Swe1 phosphorylates an N-terminal tyrosine of Hsp90. The review does not mention Hsp90.
  sources:
  - Alliance_Imported
- gene: SWI4
  text: SGD describes Swi4 acetylation at K1016 and K1066 regulating Swi6 binding, and a Slt2-independent
    cold growth role. The review covers neither.
  sources:
  - Alliance_Imported
- gene: SWI6
  text: SGD says Swi6 is required for the unfolded protein response independently of its known coactivators.
    The review does not mention the UPR.
  sources:
  - Alliance_Imported
- gene: SWS2
  text: SGD says Sws2 controls sporulation efficiency and relocates to the vacuole on H2O2. The review
    does not cover either claim and sees no known peroxisomal role.
  sources:
  - Alliance_Imported
- gene: TDH1
  text: SGD's GAPDH-derived antimicrobial peptides (shared by TDH1-3) are not mentioned in any of the
    three TDH reviews.
  sources:
  - Alliance_Imported
- gene: THR1
  text: SGD's long-lived, mother-retained protein that forms cytoplasmic filaments is not mentioned in
    the review.
  sources:
  - Alliance_Imported
- gene: TKL2
  text: No source says Tkl2 is a low-abundance isoform whose role appears only without Tkl1, which the
    review stresses.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: TOM22
  text: SGD's claim that Tom22 binds amyloid-beta residues 25-42 and passes it to Tom40 is not covered
    in the review.
  sources:
  - Alliance_Imported
- gene: TPI1
  text: SGD's regulatory claims (iron-dependent mRNA half-life, Reb1/Gcr1/Rap1 activation, PEP inhibition
    stimulating redox metabolism) are not covered in the review.
  sources:
  - Alliance_Imported
- gene: TPS1
  text: No source mentions the T6P restriction of hexokinase that makes Tps1 essential on glucose, which
    the review covers.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: TRR2
  text: SGD's claim that Trr2 and Glr1 together maintain the Trx3 redox state is not covered in the review.
  sources:
  - Alliance_Imported
- gene: TRX1
  text: SGD's roles in small-Tim (Tim9, Tim10, Tim13) mitochondrial import and in a light-sensing redox
    relay are not in the TRX1 or TRX2 reviews.
  sources:
  - Alliance_Imported
- gene: TRX2
  text: SGD's roles in small-Tim mitochondrial import and a light-sensing relay are not covered in the
    review.
  sources:
  - Alliance_Imported
- gene: TSA2
  text: SGD's report that tsa2 deletion enhances the tsa1 mutator phenotype is not covered in the review.
  sources:
  - Alliance_Imported
- gene: TSL1
  text: SGD's acute heat-stress survival and aneuploidy-tolerance phenotypes for tsl1 are not covered
    in the review.
  sources:
  - Alliance_Imported
- gene: TVP18
  text: SGD's possible ribosome association and role in intracellular sterol transport are not covered
    in the review.
  sources:
  - Alliance_Imported
- gene: UGP1
  text: SGD's regulation of UGP1 expression by Pho85 through Pho4 and its PKA-mediated oxidative stress
    and stationary-phase survival roles are not mentioned anywhere in the review.
  sources:
  - Alliance_Imported
- gene: UGP1
  text: No source mentions the review's PAS kinase (Psk1/Psk2) phosphorylation that partitions UDP-glucose
    toward glucan synthesis, or that UGP1 is essential.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: URA7
  text: SGD says Ura7 is targeted to the vacuole via the AP-3 pathway; the review does not mention AP-3
    and marks the HDA vacuole row over-annotated (cytosolic enzyme).
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: VMA1
  text: SGD's role in methionine restriction-induced extension of chronological lifespan is not mentioned
    in the review.
  sources:
  - Alliance_Imported
- gene: VTC4
  text: SGD says Vtc4 reaches the vacuole via the AP-3 pathway; the review does not mention AP-3.
  sources:
  - Alliance_Imported
- gene: XYL2
  text: SGD reports a cell wall defect in the xyl2 null mutant; the review does not mention it.
  sources:
  - Alliance_Imported
- gene: YDJ1
  text: SGD's role for Ydj1 in setting cell size at Start is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: YET2
  text: SGD says Yet2 may interact with ribosomes based on co-purification; the review does not mention
    ribosomes.
  sources:
  - Alliance_Imported
- gene: YJL045W
  text: SGD's Cat8-dependent induction during the diauxic shift is not mentioned in the review.
  sources:
  - Alliance_Imported
- gene: YMR1
  text: SGD lists a role in CVT targeting; the review discusses endosome/vacuole sorting but not the Cvt
    pathway.
  sources:
  - Alliance_Imported
- gene: YSR3
  text: UniProt's endocytosis and calcium-mediated signalling roles are not discussed in the review, which
    cites the endocytosis paper only as a reference.
  sources:
  - UniProt
- gene: ZWF1
  text: SGD's role as a negative regulator of nonselective autophagy is not mentioned in the review.
  sources:
  - Alliance_Imported
insight:
- gene: BIO6
  text: The review notes BIO6 is a BIO3 paralog with a class-III aminotransferase fold, not a BioF-family
    enzyme, so the KAPA synthase assignment that both texts repeat rests on genetics (KAPA rescue) rather
    than on assayed activity.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: CAB3
  text: None of the sources says that Cab3 supplies the catalytic cysteine of the heterotrimeric PPCDC
    and scaffolds CoA-SPC through its N-terminal extension, the review's key points.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: CAF120
  text: No source mentions the meiotic crossover role (MutLgamma-Exo1 interactor, reduced crossovers when
    deleted) that the review takes as its one functional core.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: DCV1
  text: Both sources miss the plasma membrane localization and mating front-rear polarity role that the
    review describes for this Sur7-family protein.
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: DSF2
  text: The automated G2/M regulation claim is a family inference from S. pombe Nif1. The review keeps
    it as non-core and untested.
  sources:
  - Alliance_Automated
- gene: GLO4
  text: UniProt FUNCTION text for GLO4 is copied from GLO2 and omits the matrix location that SGD and
    the review give.
  sources:
  - UniProt
- gene: TDH3
  text: 'Each moonlighting role the review accepts appears in only one source: FAS1 mRNA binding in SGD,
    heme binding and transport in the automated text.'
  sources:
  - Alliance_Imported
  - Alliance_Automated
- gene: URA1
  text: Only UniProt states the fumarate electron acceptor; none of the sources mention the horizontal
    gene transfer origin or the link to anaerobic growth that the review emphasises.
  sources:
  - UniProt
  - Alliance_Imported
  - Alliance_Automated
- gene: URH1
  text: The UniProt FUNCTION text is a dangling fragment ('Also acts on cytidine.') that has lost its
    main sentence.
  sources:
  - UniProt