title: 'Phase 1 anchor gene set: human experimental molecular adaptor activity annotations'
description: 'Human gene products carrying at least one EXPERIMENTAL annotation (evidence under

  ECO:0000269: IDA, IPI, IMP, IGI, IEP, EXP) to GO:0060090 molecular adaptor activity

  or a descendant. This is the deterministic anchor set for the Molecular Adaptor

  Activity annotation-review project; it is a worklist, not a set of curation decisions.

  Genes are grouped by ''branch'' so the epigenetic/RNA ''reader'' sub-branch and the

  scaffold and membrane-tether sub-branches can be scoped separately from the core

  protein-adaptor terms.'
source:
  resource: QuickGO annotation downloadSearch API
  go_root: GO:0060090
  go_usage: descendants over is_a, part_of, occurs_in
  taxon: 9606 (Homo sapiens)
  gene_product_type: protein
  evidence_filter: ECO:0000269 (experimental), descendants
  retrieved: '2026-11-07'
  annotation_rows: 1289
  gene_products: 666
  reviewed_flag_semantics: 'reviewed: true marks a gene with a COMPLETE gene review that covers its adaptor
    annotations, whether or not the review was produced by this project (GRB2 predates it). Use absence
    of the flag, not existing_folder, to pick un-reviewed genes.'
branch_gene_counts:
  core_adaptor: 516
  reader: 114
  scaffold: 45
  tether_anchor: 17
  note: a gene may appear in more than one branch; branches are a pragmatic surface-role grouping and
    deliberately cut across the ontology (e.g. the reader subtree nests under GO:0140463, itself a core_adaptor
    term), so counts sum above the 666 distinct genes
branch_terms:
  core_adaptor:
  - id: GO:0005068
    label: transmembrane receptor protein tyrosine kinase adaptor activity
  - id: GO:0005078
    label: MAP kinase scaffold activity
  - id: GO:0005091
    label: guanyl-nucleotide exchange factor adaptor activity
  - id: GO:0008093
    label: cytoskeletal adaptor activity
  - id: GO:0008269
    label: JAK pathway signal transduction adaptor activity
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
  - id: GO:0035591
    label: signaling adaptor activity
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
  - id: GO:0043495
    label: protein-membrane adaptor activity
  - id: GO:0060090
    label: molecular adaptor activity
  - id: GO:0140312
    label: cargo adaptor activity
  - id: GO:0140463
    label: chromatin-protein adaptor activity
  - id: GO:0140483
    label: kinetochore adaptor activity
  - id: GO:0140506
    label: endoplasmic reticulum-autophagosome adaptor activity
  - id: GO:0140517
    label: protein-RNA adaptor activity
  - id: GO:0140580
    label: mitochondrion autophagosome adaptor activity
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
  - id: GO:0140768
    label: protein ADP-ribosyltransferase-substrate adaptor activity
  - id: GO:0160134
    label: protein-RNA sequence-specific adaptor activity
  - id: GO:0160214
    label: endoplasmic reticulum-plasma membrane adaptor activity
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
  reader:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
  - id: GO:0061649
    label: ubiquitin-modified histone reader activity
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
  - id: GO:0062153
    label: C5-methylcytidine-containing RNA reader activity
  - id: GO:0140002
    label: histone H3K4me3 reader activity
  - id: GO:0140003
    label: histone H3K36me3 reader activity
  - id: GO:0140004
    label: histone H3Q5ser reader activity
  - id: GO:0140005
    label: histone H4K20me2 reader activity
  - id: GO:0140006
    label: histone H3 reader activity
  - id: GO:0140008
    label: histone H4 reader activity
  - id: GO:0140011
    label: histone H4K12ac reader activity
  - id: GO:0140012
    label: histone H4K5ac reader activity
  - id: GO:0140015
    label: histone H3K14ac reader activity
  - id: GO:0140017
    label: histone H3K18cr reader activity
  - id: GO:0140019
    label: histone H3K9cr reader activity
  - id: GO:0140035
    label: ubiquitin-like protein reader activity
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
  - id: GO:0140038
    label: histone H3K27cr reader activity
  - id: GO:0140044
    label: histone H3K18ac reader activity
  - id: GO:0140046
    label: histone H4K16ac reader activity
  - id: GO:0140055
    label: histone H4K8ac reader activity
  - id: GO:0140063
    label: unmodified histone reader activity
  - id: GO:0140072
    label: histone H3K9ac reader activity
  - id: GO:0140109
    label: histone H3K4me1 reader activity
  - id: GO:0140117
    label: histone H4K20me1 reader activity
  - id: GO:0140118
    label: histone H3K23ac reader activity
  - id: GO:0140119
    label: histone H3K27ac reader activity
  - id: GO:0140128
    label: histone H1 reader activity
  - id: GO:0140254
    label: histone H3K18ub reader activity
  - id: GO:0140257
    label: histone H3K23ub reader activity
  - id: GO:0140258
    label: histone H3K14ub reader activity
  - id: GO:0140566
    label: histone reader activity
  - id: GO:0141185
    label: UFM1-modified protein reader activity
  - id: GO:0160089
    label: internal N(7)-methylguanine-containing RNA reader activity
  - id: GO:0160267
    label: histone H1K26me1 reader activity
  - id: GO:0160268
    label: histone H1K26me2 reader activity
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
  scaffold:
  - id: GO:0140693
    label: molecular condensate scaffold activity
  tether_anchor:
  - id: GO:0106006
    label: cytoskeletal protein-membrane anchor activity
  - id: GO:0140444
    label: cytoskeleton-nuclear membrane anchor activity
  - id: GO:0140474
    label: mitochondrion-endoplasmic reticulum membrane tether activity
  - id: GO:0140585
    label: promoter-enhancer loop anchoring activity
  - id: GO:0140587
    label: chromatin loop anchoring activity
  - id: GO:0160204
    label: mitochondrion-mitochondrion outer membrane tether activity
  - id: GO:0160321
    label: vesicle docking activity
  - id: GO:0170009
    label: endoplasmic reticulum-organelle membrane tether activity
  - id: GO:0170016
    label: endoplasmic reticulum-endosome tether activity
genes:
- symbol: A1CF
  uniprot: Q9NQ94
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11871661
    - PMID:24916387
- symbol: ABI1
  uniprot: Q8IZP0
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17101133
- symbol: ABI2
  uniprot: Q9NYB9
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17101133
    - PMID:21107423
- symbol: ACAD9
  uniprot: Q9H845
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32320651
- symbol: ACP3
  uniprot: P15309
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:19995078
- symbol: ADD1
  uniprot: P35611
  branches:
  - core_adaptor
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:7642559
- symbol: ADD2
  uniprot: P35612
  branches:
  - core_adaptor
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:7642559
- symbol: AGER
  uniprot: Q15109
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:22194616
- symbol: AHDC1
  uniprot: Q5TGY3
  branches:
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0140585
    label: promoter-enhancer loop anchoring activity
    evidence:
    - IDA
    references:
    - PMID:35585237
- symbol: AIFM1
  uniprot: O95831
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39806100
- symbol: AIM2
  uniprot: O14862
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23530044
    - PMID:26197926
    - PMID:29440442
    - PMID:33980849
- symbol: AIMP2
  uniprot: Q13155
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19131329
- symbol: AKAP13
  uniprot: Q12802
  branches:
  - core_adaptor
  terms:
  - id: GO:0005078
    label: MAP kinase scaffold activity
    evidence:
    - IDA
    references:
    - PMID:21224381
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23090968
- symbol: AKAP9
  uniprot: Q99996
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11799244
    - PMID:27666745
- symbol: AKIRIN2
  uniprot: Q53H80
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34711951
- symbol: ALDOB
  uniprot: P05062
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35122041
- symbol: ALG14
  uniprot: Q96F25
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IGI
    references:
    - PMID:16100110
- symbol: ALKBH5
  uniprot: Q6P6C2
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:37474102
- symbol: ALYREF
  uniprot: Q86V81
  branches:
  - reader
  terms:
  - id: GO:0062153
    label: C5-methylcytidine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:28418038
- symbol: AMBRA1
  uniprot: Q9C0C7
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23524951
    - PMID:30166453
    - PMID:33854232
    - PMID:33854235
    - PMID:33854239
- symbol: AMFR
  uniprot: Q9UKV5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:24424410
- symbol: ANAPC7
  uniprot: Q9UJX3
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34942119
- symbol: ANK1
  uniprot: P16157
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:379653
- symbol: ANKRD13A
  uniprot: Q8IZ07
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:22298428
- symbol: ANKRD13B
  uniprot: Q86YJ7
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:22298428
- symbol: ANKRD13D
  uniprot: Q6ZTN6
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:22298428
- symbol: ANKRD9
  uniprot: Q96BM1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:30293565
- symbol: AP1M2
  uniprot: Q9Y6Q5
  branches:
  - core_adaptor
  terms:
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10338135
- symbol: AP2A1
  uniprot: O95782
  branches:
  - core_adaptor
  terms:
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23676497
- symbol: AP2A2
  uniprot: O94973
  branches:
  - core_adaptor
  terms:
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23676497
- symbol: AP2B1
  uniprot: P63010
  branches:
  - core_adaptor
  terms:
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23676497
- symbol: AP2M1
  uniprot: Q96CW1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23676497
- symbol: APBB1
  uniprot: O00213
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:36250347
- symbol: APH1A
  uniprot: Q96BI3
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:12297508
- symbol: APH1B
  uniprot: Q8WW43
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:12297508
- symbol: APPBP2
  uniprot: Q92624
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26138980
    - PMID:37844242
- symbol: AR
  uniprot: P10275
  branches:
  - core_adaptor
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11896058
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:33978290
    - PMID:36229685
- symbol: ARF6
  uniprot: P62330
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37461827
- symbol: ARHGAP26
  uniprot: Q9UNA1
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38081847
- symbol: ARMC5
  uniprot: Q96C12
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35687106
    - PMID:35862218
    - PMID:38225631
    - PMID:39504960
    - PMID:39667934
- symbol: ARPC4
  uniprot: P59998
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:11162547
- symbol: ARRB1
  uniprot: P49407
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37209686
    - PMID:40384633
    - PMID:40446798
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22810587
    - PMID:37209686
    - PMID:38175886
- symbol: ARRB2
  uniprot: P32121
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22810587
    - PMID:37209686
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22810587
    - PMID:26839314
    - PMID:35817871
    - PMID:37209686
    - PMID:38175886
- symbol: ARRDC1
  uniprot: Q8N5I2
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:27462458
- symbol: ARRDC4
  uniprot: Q8NCT1
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28594402
- symbol: ASB11
  uniprot: Q8WXH4
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24337577
    - PMID:31387940
    - PMID:38574733
- symbol: ASB7
  uniprot: Q9H672
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39039081
    - PMID:40440427
- symbol: ASB9
  uniprot: Q96DX5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25654263
    - PMID:33268465
- symbol: ATAD2B
  uniprot: Q9ULI0
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22464331
- symbol: ATG14
  uniprot: Q6ZNE5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20713597
- symbol: ATG16L1
  uniprot: Q676U5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IMP
    references:
    - PMID:30778222
- symbol: ATP1B1
  uniprot: P05026
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    - IGI
    references:
    - PMID:10636900
    - PMID:16861705
    - PMID:18075585
- symbol: ATP1B2
  uniprot: P14415
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10636900
    - PMID:19542013
- symbol: ATP1B3
  uniprot: P54709
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    - IGI
    references:
    - PMID:10636900
    - PMID:16861705
    - PMID:19542013
- symbol: ATRX
  uniprot: P46100
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21421568
- symbol: AXIN1
  uniprot: O15169
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21087614
    - PMID:9601641
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:16601693
- symbol: BAG3
  uniprot: O95817
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27884606
- symbol: BAG6
  uniprot: P46379
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:25713138
- symbol: BANK1
  uniprot: Q8NDB2
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23555801
- symbol: BBLN
  uniprot: Q9BUW7
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:33857431
- symbol: BBS4
  uniprot: Q96RK4
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:15107855
- symbol: BCL10
  uniprot: O95999
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15125833
- symbol: BCL2
  uniprot: P10415
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:26858413
- symbol: BCL3
  uniprot: P20749
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16306601
- symbol: BECN1
  uniprot: Q14457
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25891078
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34796041
- symbol: BEX1
  uniprot: Q9HBH7
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16314316
- symbol: BFAR
  uniprot: Q9NZS9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10716992
- symbol: BICD1
  uniprot: Q96G01
  branches:
  - core_adaptor
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12447383
- symbol: BLNK
  uniprot: Q8WV28
  branches:
  - core_adaptor
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11606584
    - PMID:9697839
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IMP
    references:
    - PMID:32051419
- symbol: BNIP3
  uniprot: Q12983
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140506
    label: endoplasmic reticulum-autophagosome adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22505714
  - id: GO:0140580
    label: mitochondrion autophagosome adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22505714
- symbol: BRCA2
  uniprot: P51587
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12442171
    - PMID:15937124
    - PMID:17515903
    - PMID:17515904
    - PMID:19303847
    references_truncated: 7
- symbol: BRD1
  uniprot: O95696
  branches:
  - reader
  terms:
  - id: GO:0140063
    label: unmodified histone reader activity
    evidence:
    - IDA
    references:
    - PMID:21880731
- symbol: BRD2
  uniprot: P25440
  branches:
  - reader
  terms:
  - id: GO:0140011
    label: histone H4K12ac reader activity
    evidence:
    - IDA
    references:
    - PMID:17848202
    - PMID:18406326
    - PMID:20048151
    - PMID:20709061
  - id: GO:0140012
    label: histone H4K5ac reader activity
    evidence:
    - IDA
    references:
    - PMID:18406326
    - PMID:20709061
  - id: GO:0140015
    label: histone H3K14ac reader activity
    evidence:
    - IDA
    references:
    - PMID:18406326
- symbol: BRD3
  uniprot: Q15059
  branches:
  - reader
  - scaffold
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:32895492
  - id: GO:0140017
    label: histone H3K18cr reader activity
    evidence:
    - IDA
    references:
    - PMID:27105114
  - id: GO:0140019
    label: histone H3K9cr reader activity
    evidence:
    - IDA
    references:
    - PMID:27105114
  - id: GO:0140038
    label: histone H3K27cr reader activity
    evidence:
    - IDA
    references:
    - PMID:27105114
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22464331
    - PMID:32895492
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:32895492
- symbol: BRD4
  uniprot: O60885
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140008
    label: histone H4 reader activity
    evidence:
    - IDA
    references:
    - PMID:20871596
    - PMID:23086925
    - PMID:23317504
    - PMID:29176719
  - id: GO:0140011
    label: histone H4K12ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29379197
  - id: GO:0140012
    label: histone H4K5ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29379197
  - id: GO:0140046
    label: histone H4K16ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29379197
  - id: GO:0140055
    label: histone H4K8ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29379197
  - id: GO:0140072
    label: histone H3K9ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29379197
  - id: GO:0140119
    label: histone H3K27ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29379197
- symbol: BRD7
  uniprot: Q9NPI1
  branches:
  - reader
  terms:
  - id: GO:0140015
    label: histone H3K14ac reader activity
    evidence:
    - IDA
    references:
    - PMID:16265664
- symbol: BRD9
  uniprot: Q9H8M2
  branches:
  - core_adaptor
  - reader
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32457312
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22464331
- symbol: BTRC
  uniprot: Q9Y297
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10066435
    - PMID:11158290
    - PMID:12820959
    - PMID:16705181
    - PMID:22017875
    references_truncated: 9
- symbol: C1QBP
  uniprot: Q07021
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0062153
    label: C5-methylcytidine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:39019044
- symbol: CAB39
  uniprot: Q9Y376
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IGI
    references:
    - PMID:21423148
- symbol: CALR
  uniprot: P27797
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35948544
- symbol: CAPRIN1
  uniprot: Q14444
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31439799
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:31439799
    - PMID:34074792
    - PMID:36040869
- symbol: CARD8
  uniprot: Q9Y2G2
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:33053349
- symbol: CARD9
  uniprot: Q9H257
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11053425
- symbol: CAV3
  uniprot: P56539
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IPI
    references:
    - PMID:17060380
- symbol: CBX1
  uniprot: P83916
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:41094145
  - id: GO:0160267
    label: histone H1K26me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:16127177
  - id: GO:0160268
    label: histone H1K26me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:16127177
- symbol: CBX3
  uniprot: Q13185
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:11242053
  - id: GO:0160267
    label: histone H1K26me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:16127177
  - id: GO:0160268
    label: histone H1K26me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:16127177
- symbol: CBX5
  uniprot: P45973
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:11242053
    - PMID:19783980
    - PMID:21029866
    - PMID:40440427
  - id: GO:0160267
    label: histone H1K26me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:16127177
  - id: GO:0160268
    label: histone H1K26me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:16127177
- symbol: CBX8
  uniprot: Q9HC52
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21029866
- symbol: CCDC134
  uniprot: Q9H6E4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39509507
- symbol: CCNF
  uniprot: P41002
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20596027
- symbol: CCNT1
  uniprot: O60563
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:29849146
    - PMID:35393539
- symbol: CD19
  uniprot: P15391
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - EXP
    references:
    - PMID:16672701
- symbol: CD247
  uniprot: P20963
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:7509083
- symbol: CD3E
  uniprot: P07766
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:40592325
- symbol: CD53
  uniprot: P19397
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35767951
- symbol: CDC20
  uniprot: Q12834
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27030811
    - PMID:29343641
- symbol: CDC42SE2
  uniprot: Q9NRR3
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10816584
- symbol: CDH5
  uniprot: P33151
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IMP
    references:
    - PMID:11950700
- symbol: CDK5RAP3
  uniprot: Q96JB5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:36121123
    - PMID:36543799
    - PMID:37595036
    - PMID:38383785
    - PMID:38383789
- symbol: CDKN1B
  uniprot: P46527
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:8684460
- symbol: CDY1
  uniprot: Q9Y6F8
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:18450745
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:18450745
- symbol: CDYL
  uniprot: Q9Y232
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:19061646
- symbol: CEP112
  uniprot: Q8N8E3
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:39349455
- symbol: CEP152
  uniprot: O94986
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20852615
- symbol: CEP63
  uniprot: Q96MT8
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35793002
- symbol: CEP97
  uniprot: Q8IW35
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17719545
- symbol: CGAS
  uniprot: Q8N884
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:32911482
    - PMID:32912999
    - PMID:35322803
    - PMID:38421872
    - PMID:38740774
    references_truncated: 6
- symbol: CHD1
  uniprot: O14646
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21029866
- symbol: CHD1L
  uniprot: Q86WJ1
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:34874266
- symbol: CHD5
  uniprot: Q8TDI0
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:23948251
- symbol: CHD8
  uniprot: Q9HCK8
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:17938208
- symbol: CHIC2
  uniprot: Q9UKJ5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:36108743
- symbol: CHPF
  uniprot: Q8IZ52
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:41298522
- symbol: CHPF2
  uniprot: Q9P2E5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - EXP
    - IDA
    references:
    - PMID:41298522
- symbol: CIB1
  uniprot: Q99828
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IGI
    references:
    - PMID:20639889
- symbol: CNKSR1
  uniprot: Q969H4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:14749388
- symbol: CNOT1
  uniprot: A5YKK6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22977175
- symbol: CNTLN
  uniprot: Q9NXG0
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:24554434
- symbol: COL1A2
  uniprot: P08123
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:18375391
- symbol: COL4A2
  uniprot: P08572
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:30443360
- symbol: COL4A4
  uniprot: P53420
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:30443360
- symbol: COLQ
  uniprot: Q9Y215
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:14702351
- symbol: COX7A2L
  uniprot: O14548
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:27545886
    - PMID:30428348
    - PMID:36198313
- symbol: CPT1A
  uniprot: P50416
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38016475
- symbol: CRADD
  uniprot: P78560
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:9044836
- symbol: CRBN
  uniprot: Q96SW2
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20223979
- symbol: CRK
  uniprot: P46108
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11870224
    - PMID:12384576
    - PMID:17515907
- symbol: CSNK2B
  uniprot: P67870
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31341047
- symbol: CSTPP1
  uniprot: Q9H6J7
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34782749
- symbol: DAB2
  uniprot: P98082
  branches:
  - core_adaptor
  terms:
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IMP
    references:
    - PMID:16984970
- symbol: DAB2IP
  uniprot: Q5VWQ8
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19903888
    - PMID:20080667
- symbol: DAXX
  uniprot: Q9UER7
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - EXP
    references:
    - PMID:30244836
- symbol: DCAF1
  uniprot: Q9Y4B6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23063525
    - PMID:28242748
    - PMID:34259627
- symbol: DCAF12
  uniprot: Q5T6F0
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29779948
    - PMID:31267705
    - PMID:34065512
- symbol: DCAF13
  uniprot: Q9NV06
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30111536
    - PMID:31492966
- symbol: DDB1
  uniprot: Q16531
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:14739464
- symbol: DDRGK1
  uniprot: Q96HY6
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0141185
    label: UFM1-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:36121123
    - PMID:36543799
    - PMID:37595036
    - PMID:38383785
    - PMID:38383789
- symbol: DDX3X
  uniprot: O00571
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23478265
- symbol: DDX4
  uniprot: Q9NQI0
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - EXP
    references:
    - PMID:25747659
- symbol: DDX6
  uniprot: P26196
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31439631
- symbol: DET1
  uniprot: Q7L5Y6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IPI
    references:
    - PMID:14739464
- symbol: DGCR8
  uniprot: Q8WYQ5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34188037
  - id: GO:0140517
    label: protein-RNA adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15574589
- symbol: DHX16
  uniprot: O60231
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35263596
- symbol: DNAJB2
  uniprot: P25686
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:28031292
- symbol: DNAJC2
  uniprot: Q99543
  branches:
  - reader
  terms:
  - id: GO:0061649
    label: ubiquitin-modified histone reader activity
    evidence:
    - IDA
    references:
    - PMID:21179169
- symbol: DNMT1
  uniprot: P26358
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140254
    label: histone H3K18ub reader activity
    evidence:
    - IDA
    references:
    - PMID:29053958
  - id: GO:0140257
    label: histone H3K23ub reader activity
    evidence:
    - IDA
    references:
    - PMID:29053958
  - id: GO:0140258
    label: histone H3K14ub reader activity
    evidence:
    - IDA
    references:
    - PMID:29053958
- symbol: DPF2
  uniprot: Q92785
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:29429572
  - id: GO:0140015
    label: histone H3K14ac reader activity
    evidence:
    - IDA
    references:
    - PMID:28533407
  - id: GO:0140046
    label: histone H4K16ac reader activity
    evidence:
    - IDA
    references:
    - PMID:28533407
- symbol: DRAXIN
  uniprot: Q8NBI3
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:29503192
- symbol: DTX3L
  uniprot: Q8TDB6
  branches:
  - core_adaptor
  terms:
  - id: GO:0140768
    label: protein ADP-ribosyltransferase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28525742
- symbol: DYNC1LI1
  uniprot: Q9Y6G9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30615611
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:30615611
- symbol: DZIP1
  uniprot: Q86YF9
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:27979967
- symbol: E2F1
  uniprot: Q01094
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:16360038
- symbol: ECSIT
  uniprot: Q9BQ95
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33320993
    - PMID:34646991
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25371197
- symbol: EEF1A1
  uniprot: P68104
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26651998
    - PMID:36123449
    - PMID:36264623
- symbol: ELOF1
  uniprot: P60002
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38316879
- symbol: EME2
  uniprot: A4GXA9
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35290797
- symbol: EMILIN1
  uniprot: Q9Y6C2
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:18463100
- symbol: EPC1
  uniprot: Q9H2F5
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32209463
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28694333
- symbol: ERCC2
  uniprot: P18074
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:11445587
- symbol: ERCC6
  uniprot: Q03468
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32355176
- symbol: ERCC8
  uniprot: Q13216
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12732143
    - PMID:32142649
    - PMID:34526721
    - PMID:38316879
- symbol: ERLEC1
  uniprot: Q96DZ1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21062743
- symbol: EXOC7
  uniprot: Q9UPT5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16148947
- symbol: EZH1
  uniprot: Q92800
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IMP
    references:
    - PMID:33514705
- symbol: FAAP20
  uniprot: Q6NZ36
  branches:
  - reader
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:22266823
- symbol: FADD
  uniprot: Q13158
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16762833
    - PMID:8565075
- symbol: FAF2
  uniprot: Q96CS3
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34739333
- symbol: FAM120A
  uniprot: Q9NZB2
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37595559
- symbol: FAM120A2P
  uniprot: Q5T035
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37595559
- symbol: FAN1
  uniprot: Q9Y2M0
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:20603015
    - PMID:20603016
- symbol: FBXL19
  uniprot: Q6PCT2
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22660580
    - PMID:23512198
- symbol: FBXL2
  uniprot: Q9UKC9
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26037928
- symbol: FBXL4
  uniprot: Q9UKA2
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38992176
- symbol: FBXO11
  uniprot: Q86XK2
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25827072
- symbol: FBXO24
  uniprot: O75426
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25582197
    - PMID:39384743
- symbol: FBXO28
  uniprot: Q9NVF7
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27754753
- symbol: FBXO3
  uniprot: Q9UK99
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24403578
    - PMID:26037928
- symbol: FBXO31
  uniprot: Q5XUX0
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19412162
    - PMID:23469015
    - PMID:24828503
    - PMID:24936062
    - PMID:26124108
    references_truncated: 11
- symbol: FBXO32
  uniprot: Q969P5
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:40307251
- symbol: FBXO38
  uniprot: Q6PIJ6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30487606
- symbol: FBXO4
  uniprot: Q9UKT5
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29142209
- symbol: FBXO42
  uniprot: Q6P3S6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:36129980
- symbol: FBXO44
  uniprot: Q9H4M3
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25970626
- symbol: FBXO45
  uniprot: P0C2W1
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29997255
- symbol: FBXO46
  uniprot: Q6PJ61
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30171069
- symbol: FBXO7
  uniprot: Q9Y3I1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15145941
    - PMID:36646384
- symbol: FBXO9
  uniprot: Q9UK97
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34480022
- symbol: FBXW11
  uniprot: Q9UKB1
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10321728
    - PMID:10644755
    - PMID:22017875
    - PMID:22017876
    - PMID:36608670
- symbol: FBXW7
  uniprot: Q969H0
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12628165
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15150404
    - PMID:34741373
- symbol: FBXW7
  uniprot: Q969H0-1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15150404
- symbol: FBXW8
  uniprot: Q8N3Y1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17205132
    - PMID:18498745
    - PMID:24362026
- symbol: FCRL2
  uniprot: Q96LA5
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11162587
- symbol: FEM1A
  uniprot: Q9BSK4
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16424369
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29779948
    - PMID:33398168
    - PMID:33398170
- symbol: FEM1B
  uniprot: Q9UK73
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24076122
    - PMID:29779948
    - PMID:33398168
    - PMID:33398170
- symbol: FEM1C
  uniprot: Q96JP0
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26138980
    - PMID:29775578
    - PMID:29779948
    - PMID:33398170
- symbol: FIS1
  uniprot: Q9Y3D6
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:14623186
- symbol: FKBP5
  uniprot: Q13451
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28147277
- symbol: FMR1
  uniprot: Q06787
  branches:
  - core_adaptor
  - reader
  - scaffold
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31439799
  - id: GO:0140006
    label: histone H3 reader activity
    evidence:
    - IDA
    references:
    - PMID:24813610
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - EXP
    - IDA
    - IPI
    references:
    - PMID:30765518
    - PMID:31439799
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:31753916
- symbol: FNTA
  uniprot: P49354
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11687658
- symbol: FUS
  uniprot: P35637
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - EXP
    - IDA
    - IMP
    references:
    - PMID:26317470
    - PMID:26455390
    - PMID:29677513
    - PMID:38070499
- symbol: FXR1
  uniprot: P51114
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:39106863
- symbol: FZR1
  uniprot: Q9UM11
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:14701726
- symbol: G3BP1
  uniprot: Q13283
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:32302570
    - PMID:32302571
    - PMID:32302572
    - PMID:34739333
    - PMID:36692217
- symbol: G3BP2
  uniprot: Q9UN86
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:32302570
    - PMID:32302571
    - PMID:32302572
- symbol: GAB2
  uniprot: Q9UQC2
  branches:
  - core_adaptor
  terms:
  - id: GO:0005068
    label: transmembrane receptor protein tyrosine kinase adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19172738
- symbol: GAS6
  uniprot: Q14393
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21501828
- symbol: GATAD2A
  uniprot: Q86YP4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12183469
- symbol: GCN1
  uniprot: Q92616
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:36638793
- symbol: GFI1
  uniprot: Q99684
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29651020
- symbol: GGA3
  uniprot: Q9NZ52
  branches:
  - core_adaptor
  terms:
  - id: GO:0140312
    label: cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17116753
- symbol: GIGYF2
  uniprot: Q6Y7W6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32726578
    - PMID:35878012
- symbol: GLYR1
  uniprot: Q49A26
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30970244
- symbol: GMEB1
  uniprot: Q9Y692
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31046799
- symbol: GOLPH3
  uniprot: Q9H4A6
  branches:
  - core_adaptor
  terms:
  - id: GO:0140312
    label: cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34473204
- symbol: GOLPH3L
  uniprot: Q9H4A5
  branches:
  - core_adaptor
  terms:
  - id: GO:0140312
    label: cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34473204
- symbol: GORAB
  uniprot: Q5T7V8
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30631079
- symbol: GPHN
  uniprot: Q9NQX3
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:25025157
- symbol: GPR161
  uniprot: Q8N6U8
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38326651
- symbol: GRAMD2A
  uniprot: Q8IUY3
  branches:
  - core_adaptor
  terms:
  - id: GO:0160214
    label: endoplasmic reticulum-plasma membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29469807
- symbol: GRB14
  uniprot: Q14449
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:14623073
- symbol: GRB2
  uniprot: P62993
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0005091
    label: guanyl-nucleotide exchange factor adaptor activity
    evidence:
    - IDA
    references:
    - PMID:8386805
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25870599
    - PMID:7539782
  reviewed: true
- symbol: H1-2
  uniprot: P16403
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26581166
- symbol: H2AX
  uniprot: P16104
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12419185
    - PMID:30952868
- symbol: H2AZ2
  uniprot: Q71UI9
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:24311584
- symbol: HAX1
  uniprot: O00165
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IMP
    references:
    - PMID:23001182
- symbol: HCFC1
  uniprot: P51610
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:23629655
- symbol: HCLS1
  uniprot: P14317
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IMP
    references:
    - PMID:23001182
- symbol: HCST
  uniprot: Q9UBK5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16582911
- symbol: HDAC4
  uniprot: P56524
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31127039
- symbol: HDGFL2
  uniprot: Q7Z4V5
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26721387
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26721387
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:26721387
- symbol: HELLS
  uniprot: Q9NRZ9
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31802118
- symbol: HLTF
  uniprot: Q14527
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:40680746
- symbol: HMGA1
  uniprot: P17096
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11069991
- symbol: HNRNPA2B1
  uniprot: P22626
  branches:
  - reader
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:29358076
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:26321680
- symbol: HNRNPC
  uniprot: P07910
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:25719671
- symbol: HPF1
  uniprot: Q9NWY4
  branches:
  - core_adaptor
  terms:
  - id: GO:0140768
    label: protein ADP-ribosyltransferase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28190768
    - PMID:29480802
    - PMID:32028527
    - PMID:32939087
    - PMID:33186521
    references_truncated: 15
- symbol: HSP90AA1
  uniprot: P07900
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11988487
    - PMID:12799359
- symbol: HSPA8
  uniprot: P11142
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:11559757
    - PMID:16207813
    - PMID:2799391
    - PMID:36586411
    - PMID:40281343
- symbol: HTATSF1
  uniprot: O43719
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35597237
- symbol: HTN3
  uniprot: P15516
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:26775844
- symbol: ICE1
  uniprot: Q9Y2F5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23932780
- symbol: IFFO1
  uniprot: Q0D2I5
  branches:
  - core_adaptor
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31548606
- symbol: IFI27
  uniprot: P40305
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27194766
- symbol: IFNAR1
  uniprot: P17181
  branches:
  - core_adaptor
  terms:
  - id: GO:0008269
    label: JAK pathway signal transduction adaptor activity
    evidence:
    - IDA
    references:
    - PMID:8605876
- symbol: IGF2BP1
  uniprot: Q9NZI8
  branches:
  - reader
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:29476152
- symbol: IGF2BP2
  uniprot: Q9Y6M1
  branches:
  - reader
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:29476152
    - PMID:32245947
    - PMID:36354136
- symbol: IGF2BP3
  uniprot: O00425
  branches:
  - reader
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:29476152
- symbol: IKBKG
  uniprot: Q9Y6K9
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27777308
- symbol: ING1
  uniprot: Q9UK53
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:16728974
- symbol: ING2
  uniprot: Q9H160
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:16728974
- symbol: ING3
  uniprot: Q9NXR8
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:16728974
    - PMID:19154204
- symbol: ING4
  uniprot: Q9UNL4
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:16728974
- symbol: ING5
  uniprot: Q8WYH8
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:16728974
- symbol: INSC
  uniprot: Q1MX18
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:16458856
- symbol: INSM1
  uniprot: Q01101
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:23721412
- symbol: INTS4
  uniprot: Q96HW7
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29471365
    - PMID:33548203
- symbol: INTS6
  uniprot: Q9UL03
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33243860
    - PMID:34004147
- symbol: IPPK
  uniprot: Q9H8X2
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:23203802
- symbol: IQCB1
  uniprot: Q15051
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25552655
    - PMID:28498859
- symbol: IQGAP1
  uniprot: P46940
  branches:
  - core_adaptor
  terms:
  - id: GO:0005078
    label: MAP kinase scaffold activity
    evidence:
    - IPI
    references:
    - PMID:18567582
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26242911
- symbol: IQSEC2
  uniprot: Q5JU85
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:41123449
- symbol: IRAK1
  uniprot: P51617
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IMP
    references:
    - PMID:18824541
- symbol: IRAK2
  uniprot: O43187
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17878161
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17878161
- symbol: IRGM
  uniprot: A1A4Y4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25891078
    - PMID:29420192
    - PMID:30612879
    - PMID:32715615
    - PMID:32753672
    references_truncated: 6
- symbol: IRGQ
  uniprot: Q8WZA9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39481378
- symbol: IRS1
  uniprot: P35568
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:7493946
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16878150
    - PMID:7493946
- symbol: IRS2
  uniprot: Q9Y4H2
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15316008
- symbol: ISCU
  uniprot: Q9H1K1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16527810
- symbol: ITGA2B
  uniprot: P08514
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11412103
- symbol: ITSN1
  uniprot: Q15811
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20946875
- symbol: JUP
  uniprot: P14923
  branches:
  - tether_anchor
  terms:
  - id: GO:0106006
    label: cytoskeletal protein-membrane anchor activity
    evidence:
    - IDA
    references:
    - PMID:9049256
- symbol: KANK1
  uniprot: Q14678
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27410476
- symbol: KBTBD2
  uniprot: Q8IY47
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27708159
- symbol: KCTD10
  uniprot: Q9H3F6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30404837
- symbol: KCTD13
  uniprot: Q8WZ19
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19782033
- symbol: KCTD17
  uniprot: Q8N5Z5
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25270598
- symbol: KDM4A
  uniprot: O75164
  branches:
  - reader
  terms:
  - id: GO:0140005
    label: histone H4K20me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:22373579
- symbol: KEAP1
  uniprot: Q14145
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15572695
    - PMID:15601839
- symbol: KHDRBS1
  uniprot: Q07666
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:9045636
- symbol: KIF12
  uniprot: Q96FN5
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:39920308
- symbol: KIR3DL1
  uniprot: P43629
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:30773397
- symbol: KLF12
  uniprot: Q9Y4X4
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IPI
    references:
    - PMID:35526050
- symbol: KLHDC1
  uniprot: Q8N7A1
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32200094
- symbol: KLHDC10
  uniprot: Q6PID8
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29779948
    - PMID:33909987
- symbol: KLHDC2
  uniprot: Q9Y2U9
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26138980
    - PMID:29775578
    - PMID:29779948
    - PMID:30526872
- symbol: KLHDC3
  uniprot: Q9BQ90
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26138980
    - PMID:29779948
- symbol: KLHL15
  uniprot: Q96M94
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27561354
    - PMID:35219381
- symbol: KLHL2
  uniprot: O95198
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23838290
- symbol: KLHL22
  uniprot: Q53GT1
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29769719
    - PMID:33109719
    - PMID:36394357
- symbol: KLHL25
  uniprot: Q9H0H3
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22578813
    - PMID:27664236
    - PMID:34491895
- symbol: KLHL3
  uniprot: Q9UH77
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23387299
    - PMID:23453970
    - PMID:23576762
    - PMID:35179207
- symbol: KLHL6
  uniprot: Q8WZ60
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29695787
- symbol: KMT2E
  uniprot: Q8IZD2
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:23798402
    - PMID:24130829
- symbol: KRTCAP2
  uniprot: Q8N6L1
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28860277
- symbol: L3MBTL1
  uniprot: Q9Y468
  branches:
  - reader
  terms:
  - id: GO:0140005
    label: histone H4K20me2 reader activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:17540172
    - PMID:18408754
    - PMID:22120668
  - id: GO:0140117
    label: histone H4K20me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:17540172
  - id: GO:0140128
    label: histone H1 reader activity
    evidence:
    - IDA
    references:
    - PMID:19144645
  - id: GO:0160267
    label: histone H1K26me1 reader activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:17540172
  - id: GO:0160268
    label: histone H1K26me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:17540172
- symbol: L3MBTL2
  uniprot: Q969R5
  branches:
  - reader
  terms:
  - id: GO:0140005
    label: histone H4K20me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:19233876
  - id: GO:0140117
    label: histone H4K20me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:19233876
- symbol: LALBA
  uniprot: P00709
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11419947
- symbol: LAMP2
  uniprot: P13473
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:40281343
- symbol: LAMTOR1
  uniprot: Q6IAA8
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28935770
    - PMID:29123114
    - PMID:29158492
    - PMID:29285400
    - PMID:31001086
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22980980
- symbol: LAMTOR2
  uniprot: Q9Y2Q5
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22980980
- symbol: LAMTOR3
  uniprot: Q9UHA4
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22980980
- symbol: LAMTOR4
  uniprot: Q0VGL1
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22980980
- symbol: LAMTOR5
  uniprot: O43504
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22980980
- symbol: LAT
  uniprot: O43561
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:9489702
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:9489702
- symbol: LDLR
  uniprot: P01130
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:22091758
- symbol: LDLRAP1
  uniprot: Q5SW96
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IMP
    references:
    - PMID:15166224
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12221107
  - id: GO:0035615
    label: clathrin-cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15728179
  existing_folder: true
  reviewed: true
- symbol: LGALS3
  uniprot: P17931
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:28893908
    - PMID:32144274
- symbol: LIN28A
  uniprot: Q9H9Z2
  branches:
  - core_adaptor
  terms:
  - id: GO:0140517
    label: protein-RNA adaptor activity
    evidence:
    - IDA
    references:
    - PMID:18951094
- symbol: LOX
  uniprot: P28300
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IPI
    references:
    - PMID:30082873
- symbol: LRRC58
  uniprot: Q96CX6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:40963025
- symbol: LRRC7
  uniprot: Q96NW7
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39256359
- symbol: LRRK2
  uniprot: Q5S007
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22899650
- symbol: LRWD1
  uniprot: Q9UFC0
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21029866
- symbol: LTBP1
  uniprot: Q14766
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:28669633
- symbol: LYRM4
  uniprot: Q9HD34
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28634302
- symbol: LZTR1
  uniprot: Q8N653
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30442766
- symbol: MAD2L2
  uniprot: Q9UI95
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20164194
- symbol: MAGI2
  uniprot: Q86UL8
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11526121
- symbol: MAGI3
  uniprot: Q5TCQ9
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10748157
- symbol: MAP2K1
  uniprot: Q02750
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0005078
    label: MAP kinase scaffold activity
    evidence:
    - IMP
    references:
    - PMID:29433126
- symbol: MAP2K2
  uniprot: P36507
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0005078
    label: MAP kinase scaffold activity
    evidence:
    - IMP
    references:
    - PMID:29433126
- symbol: MAPK8IP1
  uniprot: Q9UQF2
  branches:
  - core_adaptor
  terms:
  - id: GO:0005078
    label: MAP kinase scaffold activity
    evidence:
    - IPI
    references:
    - PMID:11238452
- symbol: MAPK8IP2
  uniprot: Q13387
  branches:
  - core_adaptor
  terms:
  - id: GO:0005078
    label: MAP kinase scaffold activity
    evidence:
    - IDA
    references:
    - PMID:10756100
- symbol: MAPKAP1
  uniprot: Q9BPZ7
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29567957
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21806543
    - PMID:28264193
    - PMID:35926713
- symbol: MARK4
  uniprot: Q96L34
  branches:
  - core_adaptor
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28656979
- symbol: MAVS
  uniprot: Q7Z434
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16858409
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:18818105
    - PMID:20451243
    - PMID:23582325
    - PMID:26314863
    - PMID:34880843
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16858409
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:27992402
- symbol: MBD2
  uniprot: Q9UBB5
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:25753662
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - EXP
    references:
    - PMID:25753662
- symbol: MBTD1
  uniprot: Q05BQ5
  branches:
  - reader
  terms:
  - id: GO:0140005
    label: histone H4K20me2 reader activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:19841675
    - PMID:27153538
    - PMID:32209463
  - id: GO:0140117
    label: histone H4K20me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:19841675
    - PMID:32209463
- symbol: MDC1
  uniprot: Q14676
  branches:
  - core_adaptor
  - reader
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:18006705
    - PMID:18411307
    - PMID:18582474
    - PMID:18583988
    - PMID:18678890
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:16377563
    - PMID:30898438
- symbol: MECP2
  uniprot: P51608
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:20405910
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IMP
    references:
    - PMID:32698189
- symbol: MEN1
  uniprot: O00255
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20484083
- symbol: MICAL3
  uniprot: Q7RTP6
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:27528609
- symbol: MICALL1
  uniprot: Q8N3F8
  branches:
  - core_adaptor
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31615969
- symbol: MIDN
  uniprot: Q504T8
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37616343
- symbol: MIMS2
  uniprot: Q96KR6
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:36374104
- symbol: MKI67
  uniprot: P46013
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:35513709
    - PMID:39153474
- symbol: MLLT3
  uniprot: P42568
  branches:
  - core_adaptor
  - reader
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:23260655
  - id: GO:0140044
    label: histone H3K18ac reader activity
    evidence:
    - IDA
    references:
    - PMID:25417107
  - id: GO:0140072
    label: histone H3K9ac reader activity
    evidence:
    - IDA
    references:
    - PMID:25417107
  - id: GO:0140119
    label: histone H3K27ac reader activity
    evidence:
    - IDA
    references:
    - PMID:25417107
- symbol: MLPH
  uniprot: Q9BV36
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:11980908
- symbol: MLST8
  uniprot: Q9BVC4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31085701
- symbol: MOB4
  uniprot: Q9Y3A3
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33633399
- symbol: MORC3
  uniprot: Q14149
  branches:
  - core_adaptor
  - reader
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27440897
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26933034
- symbol: MORC4
  uniprot: Q8TE76
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26933034
- symbol: MORN3
  uniprot: Q6PF18
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29681526
- symbol: MPHOSPH8
  uniprot: Q99549
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:20871592
    - PMID:39638237
- symbol: MPP7
  uniprot: Q5T2T1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17237226
    - PMID:20702775
- symbol: MSH6
  uniprot: P52701
  branches:
  - reader
  terms:
  - id: GO:0140003
    label: histone H3K36me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:23622243
- symbol: MSL1
  uniprot: Q68DK7
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22547026
- symbol: MSL3
  uniprot: Q8N5Y2
  branches:
  - reader
  terms:
  - id: GO:0140046
    label: histone H4K16ac reader activity
    evidence:
    - IDA
    references:
    - PMID:20657587
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:20657587
- symbol: MTERF4
  uniprot: Q7Z6M4
  branches:
  - core_adaptor
  terms:
  - id: GO:0140517
    label: protein-RNA adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21531335
    - PMID:34135319
- symbol: MTMR3
  uniprot: Q13615
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25659891
- symbol: MTMR4
  uniprot: Q9NYA4
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25659891
- symbol: MYD88
  uniprot: Q99836
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16751103
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16751103
    - PMID:9430229
    - PMID:9734363
- symbol: MYH9
  uniprot: P35579
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IMP
    references:
    - PMID:16403913
- symbol: MYO1F
  uniprot: O00160
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34301894
    - PMID:39694035
- symbol: MYOZ1
  uniprot: Q9NP98
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:34049882
- symbol: NBN
  uniprot: O60934
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:18411307
    - PMID:18583988
    - PMID:19804756
    - PMID:24534091
    - PMID:27814491
    references_truncated: 9
- symbol: NCAPD3
  uniprot: P42695
  branches:
  - reader
  terms:
  - id: GO:0140117
    label: histone H4K20me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:20622854
- symbol: NCAPG2
  uniprot: Q86XI2
  branches:
  - reader
  terms:
  - id: GO:0140117
    label: histone H4K20me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:20622854
- symbol: NCBP1
  uniprot: Q09161
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11545740
- symbol: NCK1
  uniprot: P16333
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21707536
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16835242
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:26553976
- symbol: NCSTN
  uniprot: Q92542
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IGI
    - IMP
    references:
    - PMID:12297508
    - PMID:12763021
- symbol: NDC80
  uniprot: O14777
  branches:
  - core_adaptor
  terms:
  - id: GO:0140483
    label: kinetochore adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30409912
- symbol: NELFA
  uniprot: Q9H3P2
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:30135580
- symbol: NF2
  uniprot: P35240
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17974916
- symbol: NFATC2
  uniprot: Q13469
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:29432148
- symbol: NFE2L2
  uniprot: Q16236
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:32727915
- symbol: NIPSNAP1
  uniprot: Q9BPW8
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30982665
- symbol: NIPSNAP2
  uniprot: O75323
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30982665
- symbol: NKD2
  uniprot: Q969F2
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:17045239
- symbol: NLRP1
  uniprot: Q9C000
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22665479
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:33420028
    - PMID:33420033
- symbol: NLRP3
  uniprot: Q96P20
  branches:
  - core_adaptor
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:1189953
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27432880
    - PMID:35114687
    - PMID:35254907
    - PMID:35559676
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:1189953
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:35114687
- symbol: NLRP4
  uniprot: Q96MN2
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27692986
- symbol: NLRP6
  uniprot: P59044
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34678144
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:34678144
- symbol: NMD3
  uniprot: Q96D46
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12773398
- symbol: NME3
  uniprot: Q13232
  branches:
  - tether_anchor
  terms:
  - id: GO:0160204
    label: mitochondrion-mitochondrion outer membrane tether activity
    evidence:
    - IDA
    references:
    - PMID:37584589
- symbol: NME4
  uniprot: O00746
  branches:
  - tether_anchor
  terms:
  - id: GO:0160204
    label: mitochondrion-mitochondrion outer membrane tether activity
    evidence:
    - IDA
    references:
    - PMID:17028143
    - PMID:23150663
- symbol: NMI
  uniprot: Q13287
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:9989503
- symbol: NMNAT2
  uniprot: Q9BZQ4
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140768
    label: protein ADP-ribosyltransferase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34314702
- symbol: NOLC1
  uniprot: Q14978
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26399832
- symbol: NPM1
  uniprot: P06748
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38231884
- symbol: NUBP1
  uniprot: P53384
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32429669
- symbol: NUFIP1
  uniprot: Q9UHK0
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:17636026
- symbol: NUP153
  uniprot: P49790
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IMP
    references:
    - PMID:12802065
    - PMID:15229283
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:21961597
    - PMID:23238392
- symbol: NUP62
  uniprot: P37198
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11244088
- symbol: NUP98
  uniprot: P52948
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:25562883
- symbol: OFD1
  uniprot: O75665
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:19800048
- symbol: OPTN
  uniprot: Q96CV9
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:25803835
- symbol: OSTC
  uniprot: Q9NRP0
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28860277
- symbol: OTUD4
  uniprot: Q01804
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25944111
- symbol: PAK4
  uniprot: O96013
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:26598620
- symbol: PAQR3
  uniprot: Q6TCH7
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26311497
- symbol: PAQR4
  uniprot: Q8N4S7
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38961186
- symbol: PARD6A
  uniprot: Q9NPB6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:14718572
- symbol: PAXX
  uniprot: Q9BUH6
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25670504
- symbol: PCBP2
  uniprot: Q15366
  branches:
  - tether_anchor
  terms:
  - id: GO:0140585
    label: promoter-enhancer loop anchoring activity
    evidence:
    - IMP
    references:
    - PMID:31361039
- symbol: PCLAF
  uniprot: Q15004
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    - IDA
    - IPI
    references:
    - PMID:25762514
- symbol: PCM1
  uniprot: Q15154
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34782749
- symbol: PCMTD1
  uniprot: Q96MG8
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35486881
- symbol: PDCD6
  uniprot: O75340
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:19520058
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IMP
    references:
    - PMID:16957052
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:27716508
- symbol: PDE4DIP
  uniprot: Q5VU43
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27666745
- symbol: PDZD8
  uniprot: Q8NEN9
  branches:
  - scaffold
  - tether_anchor
  terms:
  - id: GO:0140474
    label: mitochondrion-endoplasmic reticulum membrane tether activity
    evidence:
    - IDA
    references:
    - PMID:29097544
    - PMID:31818884
    - PMID:32686675
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:41512824
  - id: GO:0170009
    label: endoplasmic reticulum-organelle membrane tether activity
    evidence:
    - IDA
    references:
    - PMID:40839735
    - PMID:41512824
  - id: GO:0170016
    label: endoplasmic reticulum-endosome tether activity
    evidence:
    - IDA
    references:
    - PMID:31636202
    - PMID:32686675
    - PMID:33912962
- symbol: PEF1
  uniprot: Q9UBV8
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:27716508
- symbol: PEX1
  uniprot: O43933
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:19208625
    - PMID:29884772
- symbol: PEX14
  uniprot: O75381
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11438541
    - PMID:24235149
    - PMID:28765278
- symbol: PEX26
  uniprot: Q7Z412
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12717447
    - PMID:16257970
- symbol: PEX6
  uniprot: Q13608
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:19208625
    - PMID:29884772
- symbol: PGLYRP1
  uniprot: O75594
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26654597
- symbol: PGLYRP2
  uniprot: Q96PD5
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:39946201
- symbol: PHF1
  uniprot: O43189
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:23142980
  - id: GO:0140003
    label: histone H3K36me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:23142980
    - PMID:23273982
- symbol: PHF13
  uniprot: Q86YI8
  branches:
  - core_adaptor
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:23034801
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23034801
- symbol: PHF19
  uniprot: Q5T6S3
  branches:
  - reader
  terms:
  - id: GO:0140003
    label: histone H3K36me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:23104054
    - PMID:23160351
    - PMID:23273982
- symbol: PHF2
  uniprot: O75151
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:20129925
    - PMID:21167174
- symbol: PHF8
  uniprot: Q9UPP1
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:20208542
    - PMID:20346720
    - PMID:20622854
    - PMID:21029866
- symbol: PHIP
  uniprot: Q8WWQ0
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22464331
- symbol: PIH1D1
  uniprot: Q9NWS0
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IMP
    references:
    - PMID:22368283
- symbol: PKP2
  uniprot: Q99959
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:18474624
- symbol: PLCB3
  uniprot: Q01970
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    - IDA
    references:
    - PMID:23377541
- symbol: PML
  uniprot: P29590
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20719947
- symbol: POLD3
  uniprot: Q15054
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:11595739
- symbol: POLDIP2
  uniprot: Q9Y2S7
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12522211
- symbol: PPP1R10
  uniprot: Q96QC0
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30158517
    - PMID:39603239
    - PMID:39603240
- symbol: PPP1R15A
  uniprot: O75807
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26095357
- symbol: PPP1R15B
  uniprot: Q5SWA1
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15705855
- symbol: PPP1R21
  uniprot: Q6ZMI0
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37267906
- symbol: PPP1R3C
  uniprot: Q9UQK1
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - EXP
    references:
    - PMID:18070875
- symbol: PPP1R9B
  uniprot: Q96SB3
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19151759
- symbol: PPP4R2
  uniprot: Q9NY27
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:20154705
- symbol: PPTC7
  uniprot: Q8NI37
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38992176
- symbol: PRAME
  uniprot: P78395
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21822215
    - PMID:26138980
- symbol: PRAMEF6
  uniprot: Q5VXH4
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26138980
- symbol: PRAMEF9
  uniprot: P0DUQ2
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26138980
- symbol: PRDX4
  uniprot: Q13162
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:21916849
- symbol: PRNP
  uniprot: P04156
  branches:
  - core_adaptor
  - scaffold
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30401430
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:30401430
- symbol: PRPF31
  uniprot: Q8WWY3
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20118938
- symbol: PRPF6
  uniprot: O94906
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20118938
- symbol: PSEN1
  uniprot: P49768
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:9689133
- symbol: PSMD4
  uniprot: P55036
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:32157086
- symbol: PSMG1
  uniprot: O95456
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    - IGI
    references:
    - PMID:16251969
    - PMID:17189198
- symbol: PSMG2
  uniprot: Q969U7
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IGI
    references:
    - PMID:17189198
- symbol: PSMG3
  uniprot: Q9BT73
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IMP
    references:
    - PMID:17189198
    - PMID:30133132
- symbol: PTPN11
  uniprot: Q06124
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IPI
    references:
    - PMID:7493946
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26358190
- symbol: PWWP2A
  uniprot: Q96N64
  branches:
  - reader
  terms:
  - id: GO:0140003
    label: histone H3K36me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:30327463
- symbol: PYCARD
  uniprot: Q9ULZ3
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17349957
- symbol: PYGO1
  uniprot: Q9Y3Y4
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:18498752
- symbol: QKI
  uniprot: Q96PU8
  branches:
  - reader
  terms:
  - id: GO:0160089
    label: internal N(7)-methylguanine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:37379838
- symbol: QTRT2
  uniprot: Q9H974
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34241577
- symbol: RAB11FIP3
  uniprot: O75154
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:16148947
    - PMID:20026645
    - PMID:25673879
    - PMID:26258637
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:20026645
    - PMID:25673879
    - PMID:26258637
- symbol: RAB40A
  uniprot: Q8WXH6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:26598620
- symbol: RAB40B
  uniprot: Q12829
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:33999101
    - PMID:35293963
- symbol: RAB40C
  uniprot: Q96S21
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:35512830
- symbol: RACGAP1
  uniprot: Q9H0H5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11782313
- symbol: RACK1
  uniprot: P63244
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IMP
    references:
    - PMID:20103773
- symbol: RAD17
  uniprot: O75943
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24534091
- symbol: RAD50
  uniprot: Q92878
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12152085
- symbol: RAD54B
  uniprot: Q9Y620
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:25384516
- symbol: RANBP2
  uniprot: P49792
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:14729961
- symbol: RB1
  uniprot: P06400
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:16360038
- symbol: RBM33
  uniprot: Q96EV2
  branches:
  - core_adaptor
  - reader
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37257451
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:37257451
- symbol: RBM47
  uniprot: A0AV96
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24916387
- symbol: RBX1
  uniprot: P62877
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11961546
- symbol: RC3H1
  uniprot: Q5TC82
  branches:
  - core_adaptor
  terms:
  - id: GO:0160134
    label: protein-RNA sequence-specific adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28165457
- symbol: REV1
  uniprot: Q9UBZ9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23143872
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23143872
- symbol: RHNO1
  uniprot: Q9BSD3
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37440612
- symbol: RHOBTB2
  uniprot: Q9BYZ6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27941885
- symbol: RHOU
  uniprot: Q7L0Q8
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:26598620
- symbol: RICTOR
  uniprot: Q6R327
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29567957
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21343617
- symbol: RIOK3
  uniprot: O14730
  branches:
  - reader
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:39947182
    - PMID:39947183
    - PMID:40022732
- symbol: RIPK2
  uniprot: O43353
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16824733
    - PMID:29452636
    - PMID:30026309
    - PMID:30279485
    - PMID:30478312
- symbol: RNF169
  uniprot: Q8NCN4
  branches:
  - reader
  terms:
  - id: GO:0061649
    label: ubiquitin-modified histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22492721
- symbol: RPA1
  uniprot: P27694
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35597237
- symbol: RPTOR
  uniprot: Q8N122
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12150926
    - PMID:37541260
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12150926
    - PMID:12747827
    - PMID:24403073
  existing_folder: true
  reviewed: true
- symbol: RRAGA
  uniprot: Q7L523
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31601708
    - PMID:31601764
- symbol: RRAGC
  uniprot: Q9HB90
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31601708
    - PMID:31601764
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32612235
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32612235
    - PMID:36608670
- symbol: RRAGD
  uniprot: Q9NQL2
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32612235
- symbol: RUFY1
  uniprot: Q96T51
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - EXP
    references:
    - PMID:11877430
    - PMID:20534812
- symbol: RUVBL2
  uniprot: Q9Y230
  branches:
  - tether_anchor
  terms:
  - id: GO:0140585
    label: promoter-enhancer loop anchoring activity
    evidence:
    - IMP
    references:
    - PMID:23637611
- symbol: RXRG
  uniprot: P48443
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:31881311
- symbol: SARS1
  uniprot: P49591
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34268557
- symbol: SART3
  uniprot: Q15020
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32839293
- symbol: SASH1
  uniprot: O94885
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23776175
- symbol: SAYSD1
  uniprot: Q9NPB0
  branches:
  - reader
  terms:
  - id: GO:0141185
    label: UFM1-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:36848233
- symbol: SBF1
  uniprot: O95248
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - EXP
    references:
    - PMID:12668758
- symbol: SCRIB
  uniprot: Q14160
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27380321
- symbol: SEC24C
  uniprot: P53992
  branches:
  - core_adaptor
  terms:
  - id: GO:0140312
    label: cargo adaptor activity
    evidence:
    - IDA
    references:
    - PMID:41887218
- symbol: SEL1L
  uniprot: Q9UBV2
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IPI
    references:
    - PMID:18264092
- symbol: SETDB1
  uniprot: Q15047
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:29234025
  - id: GO:0140015
    label: histone H3K14ac reader activity
    evidence:
    - IDA
    references:
    - PMID:29234025
- symbol: SGF29
  uniprot: Q96ES7
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26421618
  - id: GO:0140003
    label: histone H3K36me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:20850016
- symbol: SH2B2
  uniprot: O14492
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:9233773
- symbol: SH2D1A
  uniprot: O60880
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15713798
- symbol: SH3BGRL
  uniprot: O75368
  branches:
  - core_adaptor
  terms:
  - id: GO:0140517
    label: protein-RNA adaptor activity
    evidence:
    - IMP
    references:
    - PMID:34331014
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IMP
    references:
    - PMID:34331014
- symbol: SHISA5
  uniprot: Q8N114
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    - IMP
    references:
    - PMID:37816329
- symbol: SIKE1
  uniprot: Q9BRV8
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30622739
- symbol: SIT1
  uniprot: Q9Y3P8
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10209036
- symbol: SKP1
  uniprot: P63208
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12820959
- symbol: SKP2
  uniprot: Q13309
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22464731
- symbol: SLA2
  uniprot: Q9H6Q3
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11891219
- symbol: SLC9D1
  uniprot: Q6UWJ1
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:40285646
- symbol: SLMAP
  uniprot: Q14BN4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29063833
    - PMID:30622739
- symbol: SMAD6
  uniprot: O43541
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16299379
    - PMID:19561075
    - PMID:21897371
- symbol: SMAD7
  uniprot: O15105
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11278251
- symbol: SMARCD1
  uniprot: Q96GM5
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12917342
- symbol: SMDT1
  uniprot: Q9H4I9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32494073
    - PMID:32762847
- symbol: SMIM26
  uniprot: A0A096LP01
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:40578345
    - PMID:41991342
- symbol: SNX27
  uniprot: Q96L92
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21602791
- symbol: SOCS2
  uniprot: O14508
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11781573
    - PMID:21980433
    - PMID:25505247
    - PMID:34857742
- symbol: SOD3
  uniprot: P08294
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:19289127
- symbol: SORBS1
  uniprot: Q9BX66
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11374898
- symbol: SOS1
  uniprot: Q07889
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:27056844
- symbol: SP1
  uniprot: P08047
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:22855260
- symbol: SPACA6
  uniprot: W5XKT8
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39423812
- symbol: SPATA18
  uniprot: Q8TC71
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:38322995
- symbol: SPATA2
  uniprot: Q9UM82
  branches:
  - core_adaptor
  terms:
  - id: GO:0030159
    label: signaling receptor complex adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27545878
- symbol: SPIN1
  uniprot: Q9Y657
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21029866
    - PMID:21960006
    - PMID:23077255
    - PMID:24589551
    - PMID:29061846
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:33574238
- symbol: SPIN2A
  uniprot: Q99865
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:29061846
- symbol: SPIN2B
  uniprot: Q9BPZ2
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:29061846
- symbol: SPIN3
  uniprot: Q5JUX0
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:29061846
- symbol: SPIN4
  uniprot: Q56A73
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:29061846
- symbol: SPSB1
  uniprot: Q96BD6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IPI
    references:
    - PMID:21199876
- symbol: SPSB2
  uniprot: Q99619
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IPI
    references:
    - PMID:21199876
- symbol: SPSB3
  uniprot: Q6PJ21
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29059170
    - PMID:38418882
- symbol: SPSB4
  uniprot: Q96A44
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IPI
    references:
    - PMID:21199876
- symbol: SQSTM1
  uniprot: Q13501
  branches:
  - core_adaptor
  - reader
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26344566
    - PMID:27498865
    - PMID:30612879
    - PMID:31857589
    - PMID:32715615
    references_truncated: 8
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27498865
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:22017874
    - PMID:27498865
    - PMID:31857589
    - PMID:34893540
    - PMID:36221902
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:29343546
    - PMID:29507397
    - PMID:31857589
    - PMID:37306101
    - PMID:37802024
- symbol: SRRT
  uniprot: Q9BXP5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28297668
- symbol: SRSF3
  uniprot: P84103
  branches:
  - core_adaptor
  terms:
  - id: GO:0160134
    label: protein-RNA sequence-specific adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32440474
- symbol: STAP1
  uniprot: Q9ULZ2
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IPI
    references:
    - PMID:10518561
- symbol: STAT3
  uniprot: P40763
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IPI
    references:
    - PMID:31145836
- symbol: STEEP1
  uniprot: Q9H5V9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32690950
    - PMID:37832545
- symbol: STING1
  uniprot: Q86WV6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23747010
    - PMID:25636800
    - PMID:37086726
    - PMID:37832545
    - PMID:40973797
    references_truncated: 6
- symbol: STK38
  uniprot: Q15208
  branches:
  - reader
  terms:
  - id: GO:0140035
    label: ubiquitin-like protein reader activity
    evidence:
    - IDA
    references:
    - PMID:32537488
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:32537488
  - id: GO:0141185
    label: UFM1-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:32537488
- symbol: STRIP1
  uniprot: Q5VSL9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30622739
    - PMID:33633399
- symbol: STRN3
  uniprot: Q13033
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:30622739
- symbol: STRN4
  uniprot: Q9NRL3
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32640226
- symbol: STXBP2
  uniprot: Q15833
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28265073
- symbol: SUN1
  uniprot: O94901
  branches:
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0140444
    label: cytoskeleton-nuclear membrane anchor activity
    evidence:
    - IDA
    references:
    - PMID:18396275
- symbol: SUN2
  uniprot: Q9UH99
  branches:
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0140444
    label: cytoskeleton-nuclear membrane anchor activity
    evidence:
    - IDA
    references:
    - PMID:18396275
- symbol: SURF6
  uniprot: O75683
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:30498217
- symbol: SUV39H1
  uniprot: O43463
  branches:
  - reader
  terms:
  - id: GO:0140258
    label: histone H3K14ub reader activity
    evidence:
    - IDA
    references:
    - PMID:41094145
- symbol: SUV39H2
  uniprot: Q9H5I1
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:41094145
  - id: GO:0140258
    label: histone H3K14ub reader activity
    evidence:
    - IDA
    references:
    - PMID:41094145
- symbol: SUZ12
  uniprot: Q15022
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21029866
- symbol: SYNE1
  uniprot: Q8NF91
  branches:
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0140444
    label: cytoskeleton-nuclear membrane anchor activity
    evidence:
    - IDA
    references:
    - PMID:18396275
- symbol: SYNE2
  uniprot: Q8WXH0
  branches:
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0140444
    label: cytoskeleton-nuclear membrane anchor activity
    evidence:
    - IDA
    references:
    - PMID:18396275
- symbol: SYNE3
  uniprot: Q6ZMZ3
  branches:
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0140444
    label: cytoskeleton-nuclear membrane anchor activity
    evidence:
    - IDA
    references:
    - PMID:18396275
- symbol: TAB1
  uniprot: Q15750
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16260783
- symbol: TAB2
  uniprot: Q9NYJ8
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10882101
    - PMID:36681779
- symbol: TAB3
  uniprot: Q8N5C8
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15327770
- symbol: TAF1
  uniprot: P21675
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IPI
    references:
    - PMID:24927529
  - id: GO:0140046
    label: histone H4K16ac reader activity
    evidence:
    - IDA
    references:
    - PMID:17996705
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:24927529
- symbol: TAF1L
  uniprot: Q8IZX4
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22464331
- symbol: TAF3
  uniprot: Q5VWG9
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:17884155
- symbol: TAF7
  uniprot: Q15545
  branches:
  - reader
  terms:
  - id: GO:0061628
    label: histone H3K27me3 reader activity
    evidence:
    - IPI
    references:
    - PMID:24927529
- symbol: TANK
  uniprot: Q92844
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21931631
- symbol: TAPBP
  uniprot: O15533
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17947644
- symbol: TARDBP
  uniprot: Q13148
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:27545621
    - PMID:28988034
    - PMID:29511089
- symbol: TASOR
  uniprot: Q9UK61
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33009411
- symbol: TASOR2
  uniprot: Q5VWN6
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39013473
- symbol: TAX1BP1
  uniprot: Q86VP1
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27736772
    - PMID:28898289
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:18239685
- symbol: TBC1D31
  uniprot: Q96DN5
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33934390
- symbol: TCAP
  uniprot: O15273
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:15582318
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:16713295
- symbol: TCOF1
  uniprot: Q13428
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:26399832
- symbol: TDRD3
  uniprot: Q9H7E2
  branches:
  - reader
  terms:
  - id: GO:0140006
    label: histone H3 reader activity
    evidence:
    - IDA
    references:
    - PMID:21172665
  - id: GO:0140008
    label: histone H4 reader activity
    evidence:
    - IDA
    references:
    - PMID:21172665
- symbol: TGFBR2
  uniprot: P37173
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:18243111
- symbol: THAP7
  uniprot: Q9BT49
  branches:
  - reader
  terms:
  - id: GO:0140008
    label: histone H4 reader activity
    evidence:
    - IDA
    references:
    - PMID:15561719
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:15561719
    - PMID:16195249
- symbol: TIAL1
  uniprot: Q01085
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140517
    label: protein-RNA adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33203680
- symbol: TICAM1
  uniprot: Q8IUC6
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12471095
- symbol: TICAM2
  uniprot: Q86XR7
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28630139
- symbol: TIMM29
  uniprot: Q9BSF4
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27554484
- symbol: TIRAP
  uniprot: P58753
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17322885
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:16751103
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:11544529
    - PMID:16751103
- symbol: TJP2
  uniprot: Q9UDY2
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23885123
- symbol: TMA16
  uniprot: Q96EY4
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32669547
- symbol: TMEM70
  uniprot: Q9BUB7
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32275929
- symbol: TMEM81
  uniprot: Q6P7N7
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39423812
- symbol: TNFAIP1
  uniprot: Q13829
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19782033
- symbol: TNRC18
  uniprot: O15417
  branches:
  - core_adaptor
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:37938770
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37938770
- symbol: TNRC6A
  uniprot: Q8NDV7
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - HDA
    references:
    - PMID:22681889
- symbol: TOLLIP
  uniprot: Q9H0E2
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10854325
    - PMID:27368102
- symbol: TOMM70
  uniprot: O94826
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20628368
- symbol: TONSL
  uniprot: Q96HA7
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:26527279
    - PMID:27338793
    - PMID:29478807
- symbol: TOP1
  uniprot: P11387
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - EXP
    - IDA
    references:
    - PMID:38287572
- symbol: TOPBP1
  uniprot: Q92547
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17575048
    - PMID:20545769
    - PMID:21777809
    - PMID:26811421
    - PMID:30898438
    references_truncated: 8
- symbol: TP53
  uniprot: P04637
  branches:
  - scaffold
  existing_folder: true
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:31953488
    - PMID:35618207
    - PMID:36108750
    - PMID:36634798
    - PMID:38653238
- symbol: TP53BP1
  uniprot: Q12888
  branches:
  - reader
  terms:
  - id: GO:0061649
    label: ubiquitin-modified histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22492721
    - PMID:23760478
    - PMID:27153538
    - PMID:32209463
  - id: GO:0140005
    label: histone H4K20me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:22373579
    - PMID:23760478
    - PMID:27153538
    - PMID:28241136
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:23760478
    - PMID:27153538
- symbol: TPGS1
  uniprot: Q6ZTW0
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34782749
- symbol: TPGS2
  uniprot: Q68CL5
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:34782749
- symbol: TPR
  uniprot: P12270
  branches:
  - core_adaptor
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IMP
    references:
    - PMID:12802065
- symbol: TPX2
  uniprot: Q9ULW0
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37728657
- symbol: TRABD
  uniprot: Q9H4I3
  branches:
  - tether_anchor
  terms:
  - id: GO:0160204
    label: mitochondrion-mitochondrion outer membrane tether activity
    evidence:
    - IMP
    references:
    - PMID:38843396
- symbol: TRADD
  uniprot: Q15628
  branches:
  - core_adaptor
  terms:
  - id: GO:0005068
    label: transmembrane receptor protein tyrosine kinase adaptor activity
    evidence:
    - IPI
    references:
    - PMID:8612133
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:7758105
- symbol: TRAF1
  uniprot: Q13077
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20385093
- symbol: TRAF2
  uniprot: Q12933
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    - IPI
    references:
    - PMID:20447407
    - PMID:38354704
    - PMID:8565075
- symbol: TRAF3IP3
  uniprot: Q9Y228
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31390091
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:31390091
- symbol: TRAF6
  uniprot: Q9Y4K3
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:18758450
- symbol: TREX2
  uniprot: Q9BQ50
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:15661738
- symbol: TRIM11
  uniprot: Q96F44
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27498865
- symbol: TRIM14
  uniprot: Q14142
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35145029
- symbol: TRIM17
  uniprot: Q9Y577
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:25127057
- symbol: TRIM22
  uniprot: Q8IYM9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:25127057
- symbol: TRIM24
  uniprot: O15164
  branches:
  - reader
  terms:
  - id: GO:0140118
    label: histone H3K23ac reader activity
    evidence:
    - IDA
    references:
    - PMID:21164480
- symbol: TRIM28
  uniprot: Q13263
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38495890
    - PMID:41109928
- symbol: TRIM32
  uniprot: Q13049
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28898289
- symbol: TRIM5
  uniprot: Q9C035
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:25127057
- symbol: TRIM55
  uniprot: Q9BYV6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37816088
- symbol: TRIM6
  uniprot: Q9C030
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IPI
    references:
    - PMID:25127057
- symbol: TRPC4AP
  uniprot: Q8TEL6
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29779948
- symbol: TTC1
  uniprot: Q99614
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22711498
- symbol: TTLL12
  uniprot: Q14166
  branches:
  - reader
  terms:
  - id: GO:0140005
    label: histone H4K20me2 reader activity
    evidence:
    - IDA
    references:
    - PMID:23251473
- symbol: TULP3
  uniprot: O75386
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:20889716
    - PMID:36775821
- symbol: TUT1
  uniprot: Q9H6E5
  branches:
  - core_adaptor
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:21102410
- symbol: TYROBP
  uniprot: O43914
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23459077
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:10799849
    - PMID:26358190
- symbol: UBE2Z
  uniprot: Q9H832
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:26555268
- symbol: UBL7
  uniprot: Q96S82
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:36943869
- symbol: UBQLN2
  uniprot: Q9UHD9
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:29526694
- symbol: UBR4
  uniprot: Q5T4S7
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:23555265
- symbol: UHRF1
  uniprot: Q96T88
  branches:
  - reader
  terms:
  - id: GO:0062072
    label: histone H3K9me2/3 reader activity
    evidence:
    - IDA
    references:
    - PMID:17967883
    - PMID:21029866
    - PMID:21489993
    - PMID:23022729
    - PMID:30104358
- symbol: UIMC1
  uniprot: Q96RL1
  branches:
  - reader
  terms:
  - id: GO:0061649
    label: ubiquitin-modified histone reader activity
    evidence:
    - IDA
    references:
    - PMID:22492721
- symbol: ULK4
  uniprot: Q96C45
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:38096226
- symbol: USP15
  uniprot: Q9Y4E8
  branches:
  - reader
  terms:
  - id: GO:0061649
    label: ubiquitin-modified histone reader activity
    evidence:
    - IDA
    references:
    - PMID:24526689
- symbol: USP18
  uniprot: Q9UMW8
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27801882
- symbol: UVSSA
  uniprot: Q2YD98
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32355176
- symbol: VAPA
  uniprot: Q9P0L0
  branches:
  - core_adaptor
  - tether_anchor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:19564404
    - PMID:32234213
    - PMID:34688657
    - PMID:39106189
    - PMID:41856286
  - id: GO:0170016
    label: endoplasmic reticulum-endosome tether activity
    evidence:
    - IDA
    references:
    - PMID:33124732
    - PMID:41741634
- symbol: VAPB
  uniprot: O95292
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0043495
    label: protein-membrane adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33296653
- symbol: VCP
  uniprot: P55072
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:0140036
    label: ubiquitin-modified protein reader activity
    evidence:
    - IDA
    references:
    - PMID:29033132
    - PMID:31387940
    - PMID:35013556
- symbol: VHL
  uniprot: P40337
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:10205047
    - PMID:12004076
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24899725
    - PMID:34290272
- symbol: VIM
  uniprot: P08670
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - EXP
    references:
    - PMID:22869704
- symbol: VPS11
  uniprot: Q9H270
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37821429
- symbol: VPS16
  uniprot: Q9H269
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37821429
- symbol: VPS18
  uniprot: Q9P253
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37821429
- symbol: VPS33A
  uniprot: Q96AX1
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37821429
- symbol: VPS39
  uniprot: Q96JC1
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24554770
    - PMID:37821429
- symbol: VPS41
  uniprot: P49754
  branches:
  - core_adaptor
  terms:
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37821429
- symbol: WARS1
  uniprot: P23381
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22504299
- symbol: WDR5
  uniprot: P61964
  branches:
  - reader
  terms:
  - id: GO:0140004
    label: histone H3Q5ser reader activity
    evidence:
    - IDA
    references:
    - PMID:16600877
  - id: GO:0140109
    label: histone H3K4me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:18840606
- symbol: WDR6
  uniprot: Q9NNW5
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140767
    label: enzyme-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32558197
- symbol: WDR73
  uniprot: Q6P4I2
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:39032489
- symbol: WIPF1
  uniprot: O43516
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0008093
    label: cytoskeletal adaptor activity
    evidence:
    - IDA
    references:
    - PMID:17141616
- symbol: WIPI1
  uniprot: Q5MNZ9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28561066
- symbol: WNK1
  uniprot: Q9H4A3
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:36318922
- symbol: WNK3
  uniprot: Q9BYP7
  branches:
  - scaffold
  terms:
  - id: GO:0140693
    label: molecular condensate scaffold activity
    evidence:
    - IDA
    references:
    - PMID:36318922
- symbol: WWC1
  uniprot: Q8IX03
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35429439
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24682284
- symbol: WWC2
  uniprot: Q6AWC2
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35429439
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24682284
- symbol: WWC3
  uniprot: Q9ULE0
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:35429439
  - id: GO:0060090
    label: molecular adaptor activity
    evidence:
    - IDA
    references:
    - PMID:24682284
- symbol: XK
  uniprot: P51811
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:32845802
- symbol: XRCC4
  uniprot: Q13426
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IMP
    references:
    - PMID:31548606
- symbol: YBX1
  uniprot: P67809
  branches:
  - reader
  terms:
  - id: GO:0062153
    label: C5-methylcytidine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:31358969
    - PMID:32015133
- symbol: YEATS2
  uniprot: Q9ULM3
  branches:
  - reader
  terms:
  - id: GO:0140566
    label: histone reader activity
    evidence:
    - IDA
    references:
    - PMID:27103431
- symbol: YEATS4
  uniprot: O95619
  branches:
  - reader
  terms:
  - id: GO:0140044
    label: histone H3K18ac reader activity
    evidence:
    - IDA
    references:
    - PMID:30071723
  - id: GO:0140119
    label: histone H3K27ac reader activity
    evidence:
    - IDA
    references:
    - PMID:30071723
- symbol: YKT6
  uniprot: O15498
  branches:
  - tether_anchor
  terms:
  - id: GO:0160321
    label: vesicle docking activity
    evidence:
    - IDA
    references:
    - PMID:9211930
- symbol: YTHDC1
  uniprot: Q96MU7
  branches:
  - reader
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:25242552
    - PMID:26318451
    - PMID:26876937
    - PMID:27602518
    - PMID:28984244
- symbol: YTHDC2
  uniprot: Q9H6S0
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:26318451
    - PMID:28809393
    - PMID:29033321
- symbol: YTHDF1
  uniprot: Q9BYJ9
  branches:
  - reader
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:24284625
    - PMID:26046440
    - PMID:26318451
    - PMID:28106072
    - PMID:28106076
    references_truncated: 8
- symbol: YTHDF2
  uniprot: Q9Y5A9
  branches:
  - reader
  terms:
  - id: GO:0062153
    label: C5-methylcytidine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:31815440
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:22575960
    - PMID:24284625
    - PMID:25412658
    - PMID:25412661
    - PMID:26046440
    references_truncated: 15
- symbol: YTHDF3
  uniprot: Q7Z739
  branches:
  - reader
  existing_folder: true
  terms:
  - id: GO:1990247
    label: N6-methyladenosine-containing RNA reader activity
    evidence:
    - IDA
    references:
    - PMID:22575960
    - PMID:24284625
    - PMID:28106072
    - PMID:28106076
    - PMID:31292544
    references_truncated: 7
- symbol: YWHAE
  uniprot: P62258
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:22607805
- symbol: ZC3H18
  uniprot: Q86VM9
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:28297668
- symbol: ZCWPW1
  uniprot: Q9H0M4
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IMP
    references:
    - PMID:20826339
- symbol: ZCWPW2
  uniprot: Q504Y3
  branches:
  - reader
  terms:
  - id: GO:0140002
    label: histone H3K4me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:26933034
- symbol: ZDHHC11
  uniprot: Q9H8X9
  branches:
  - core_adaptor
  terms:
  - id: GO:0035591
    label: signaling adaptor activity
    evidence:
    - IDA
    references:
    - PMID:29429998
- symbol: ZFP36
  uniprot: P26651
  branches:
  - core_adaptor
  terms:
  - id: GO:0160134
    label: protein-RNA sequence-specific adaptor activity
    evidence:
    - IDA
    references:
    - PMID:12748283
- symbol: ZFYVE27
  uniprot: Q5T4F4
  branches:
  - tether_anchor
  terms:
  - id: GO:0170016
    label: endoplasmic reticulum-endosome tether activity
    evidence:
    - IDA
    references:
    - PMID:25855459
    - PMID:32686675
- symbol: ZMYND11
  uniprot: Q15326
  branches:
  - reader
  terms:
  - id: GO:0140003
    label: histone H3K36me3 reader activity
    evidence:
    - IDA
    references:
    - PMID:24675531
- symbol: ZMYND8
  uniprot: Q9ULU4
  branches:
  - reader
  terms:
  - id: GO:0140015
    label: histone H3K14ac reader activity
    evidence:
    - IDA
    references:
    - PMID:27477906
  - id: GO:0140109
    label: histone H3K4me1 reader activity
    evidence:
    - IDA
    references:
    - PMID:27477906
- symbol: ZNF143
  uniprot: P52747
  branches:
  - tether_anchor
  terms:
  - id: GO:0140587
    label: chromatin loop anchoring activity
    evidence:
    - IDA
    references:
    - PMID:39708803
- symbol: ZNF432
  uniprot: O94892
  branches:
  - core_adaptor
  terms:
  - id: GO:0030674
    label: protein-macromolecule adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37823600
- symbol: ZNF598
  uniprot: Q86UK7
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:0140517
    label: protein-RNA adaptor activity
    evidence:
    - IDA
    references:
    - PMID:32726578
- symbol: ZNF618
  uniprot: Q5T7W0
  branches:
  - core_adaptor
  terms:
  - id: GO:0140463
    label: chromatin-protein adaptor activity
    evidence:
    - IDA
    references:
    - PMID:27129234
- symbol: ZNRD2
  uniprot: O60232
  branches:
  - core_adaptor
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:37480851
- symbol: ZSWIM8
  uniprot: A7E2V4
  branches:
  - core_adaptor
  existing_folder: true
  terms:
  - id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    evidence:
    - IDA
    references:
    - PMID:33184234
    - PMID:33184237