# Manual review of HTP-family vesicle-type rows, 2026-10-10. Source: decisions_settled.py - gene: human/A1BG row_index: 12 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma glycoprotein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A1BG row_index: 14 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma glycoprotein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A1BG row_index: 15 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma glycoprotein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A2M row_index: 13 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma protease inhibitor. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A2M row_index: 15 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma protease inhibitor. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A2M row_index: 17 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma protease inhibitor. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A2M row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma protease inhibitor. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/A2ML1 row_index: 2 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted protease inhibitor. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/AASDHPPT row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphopantetheinyl transferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ABHD8 row_index: 13 term: GO:0070062 extracellular exosome reference: PMID:18570454 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic hydrolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ACAT1 row_index: 32 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Mitochondrial acetyl-CoA acetyltransferase. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/ACAT1 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Mitochondrial acetyl-CoA acetyltransferase. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/ACTA2 row_index: 43 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Smooth-muscle actin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ACTB row_index: 214 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ACTB row_index: 235 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ADAM10 row_index: 108 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane metalloprotease. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ADIRF row_index: 6 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: UniProt places ADIRF in the nucleus only. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/ADIRF row_index: 7 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: UniProt places ADIRF in the nucleus only. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/AGRN row_index: 80 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted heparan-sulfate proteoglycan; its proteoglycan-binding annotations are by sequence similarity only (ISS). Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/AGRN row_index: 81 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted heparan-sulfate proteoglycan; its proteoglycan-binding annotations are by sequence similarity only (ISS). Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/AGRN row_index: 82 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted heparan-sulfate proteoglycan; its proteoglycan-binding annotations are by sequence similarity only (ISS). Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/AHCY row_index: 21 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic adenosylhomocysteinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/AHNAK row_index: 59 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Large scaffold protein that shuttles to the cytoplasmic face of the plasma membrane. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/AHNAK row_index: 60 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Large scaffold protein that shuttles to the cytoplasmic face of the plasma membrane. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/AHSA1 row_index: 29 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic HSP90 co-chaperone. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/AKR1C4 row_index: 54 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic aldo-keto reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALAD row_index: 53 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic porphobilinogen synthase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALCAM row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane adhesion molecule. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ALCAM row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane adhesion molecule. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ALDOA row_index: 32 term: GO:0070062 extracellular exosome reference: PMID:12519789 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glycolytic aldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALDOA row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glycolytic aldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALDOA row_index: 38 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glycolytic aldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALDOA row_index: 39 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glycolytic aldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALDOA row_index: 40 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glycolytic aldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ALPL row_index: 67 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane phosphatase; UniProt also records an EV-membrane pool. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/AMN row_index: 30 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane cubilin partner. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ANKFY1 row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:18570454 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral endosome-membrane protein. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/ANKFY1 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral endosome-membrane protein. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/APLP2 row_index: 40 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane amyloid precursor-like protein. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/APOE row_index: 191 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted apolipoprotein (UniProt). Not a MISEV2018 (PMID:30637094) negative marker (it names APOA1/2 and APOB), and these samples are urine, prostatic secretion, B-cell culture and CSF rather than plasma. van Niel et al. (PMID:26387950) show ApoE on endosomal intraluminal vesicles that are secreted as exosomes, so the location is real; it is secondary to APOE's lipoprotein role. True, but not its core location. (Confirms the existing KEEP_AS_NON_CORE; the plasma-microvesicle row stays over-annotated in pass 1.) - gene: human/APOE row_index: 194 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted apolipoprotein (UniProt). Not a MISEV2018 (PMID:30637094) negative marker (it names APOA1/2 and APOB), and these samples are urine, prostatic secretion, B-cell culture and CSF rather than plasma. van Niel et al. (PMID:26387950) show ApoE on endosomal intraluminal vesicles that are secreted as exosomes, so the location is real; it is secondary to APOE's lipoprotein role. True, but not its core location. (Confirms the existing KEEP_AS_NON_CORE; the plasma-microvesicle row stays over-annotated in pass 1.) - gene: human/APOE row_index: 210 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted apolipoprotein (UniProt). Not a MISEV2018 (PMID:30637094) negative marker (it names APOA1/2 and APOB), and these samples are urine, prostatic secretion, B-cell culture and CSF rather than plasma. van Niel et al. (PMID:26387950) show ApoE on endosomal intraluminal vesicles that are secreted as exosomes, so the location is real; it is secondary to APOE's lipoprotein role. True, but not its core location. (Confirms the existing KEEP_AS_NON_CORE; the plasma-microvesicle row stays over-annotated in pass 1.) - gene: human/APOE row_index: 211 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted apolipoprotein (UniProt). Not a MISEV2018 (PMID:30637094) negative marker (it names APOA1/2 and APOB), and these samples are urine, prostatic secretion, B-cell culture and CSF rather than plasma. van Niel et al. (PMID:26387950) show ApoE on endosomal intraluminal vesicles that are secreted as exosomes, so the location is real; it is secondary to APOE's lipoprotein role. True, but not its core location. (Confirms the existing KEEP_AS_NON_CORE; the plasma-microvesicle row stays over-annotated in pass 1.) - gene: human/APOH row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted plasma beta-2-glycoprotein I, which binds anionic phospholipids. MISEV2018 (PMID:30637094) category 5 allows secreted proteins to associate with EVs through promiscuous lipid receptors on the EV surface, so the detection is plausible. (Confirms the existing KEEP_AS_NON_CORE.) - gene: human/ARL15 row_index: 9 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: 'Little-characterized Arf-like small GTPase: neither UniProt nor GO records a location other than EV proteomes. Arf-family GTPases cycle between the cytosol and membranes, and MISEV2018 (PMID:30637094) category 2 treats such proteins as expected EV contents, so the detection is plausible. True, but not its core location.' - gene: human/ARL15 row_index: 10 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: 'Little-characterized Arf-like small GTPase: neither UniProt nor GO records a location other than EV proteomes. Arf-family GTPases cycle between the cytosol and membranes, and MISEV2018 (PMID:30637094) category 2 treats such proteins as expected EV contents, so the detection is plausible. True, but not its core location.' - gene: human/ARMC3 row_index: 3 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: 'Little-characterized armadillo-repeat protein: neither UniProt nor GO records a location other than EV proteomes; UniProt infers two S-palmitoyl cysteines by similarity, a membrane-binding modification. MISEV2018 (PMID:30637094) category 2 treats cytosolic and membrane-binding proteins as expected EV contents, so the detection is plausible. True, but not its core location.' - gene: human/ARPC4 row_index: 60 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Arp2/3 complex subunit (cytoskeleton). Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ARPC4 row_index: 61 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Arp2/3 complex subunit (cytoskeleton). Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ARPC5 row_index: 52 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Arp2/3 complex subunit (cytoskeleton). Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ARPC5 row_index: 53 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Arp2/3 complex subunit (cytoskeleton). Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ARSL row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Golgi-resident arylsulfatase. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/ASAH1 row_index: 49 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal acid ceramidase; UniProt notes secretion is extremely low. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/ASAH1 row_index: 50 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal acid ceramidase; UniProt notes secretion is extremely low. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/ASL row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic argininosuccinate lyase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ASS1 row_index: 76 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic argininosuccinate synthase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/ATP5F1A row_index: 71 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial ATP synthase subunit; ecto-ATP synthase plasma-membrane pool by IDA (PMID:10077593). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/ATP5F1A row_index: 75 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial ATP synthase subunit; ecto-ATP synthase plasma-membrane pool by IDA (PMID:10077593). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/ATP5F1B row_index: 68 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial ATP synthase subunit; ecto-ATP synthase cell-surface pool by IDA (PMID:17510399). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/ATP5F1B row_index: 72 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial ATP synthase subunit; ecto-ATP synthase cell-surface pool by IDA (PMID:17510399). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/ATP5F1B row_index: 73 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial ATP synthase subunit; ecto-ATP synthase cell-surface pool by IDA (PMID:17510399). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/ATP5F1B row_index: 74 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial ATP synthase subunit; ecto-ATP synthase cell-surface pool by IDA (PMID:17510399). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/ATP6AP2 row_index: 54 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass membrane protein of the endolysosomal V-ATPase assembly. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ATP6V0A4 row_index: 25 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane V-ATPase subunit. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ATP6V0A4 row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane V-ATPase subunit. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ATP6V0C row_index: 56 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: V-ATPase membrane subunit of endosomal/vesicle membranes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt membrane topology; compartment from GO); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ATP6V0D1 row_index: 43 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral V-ATPase V0 subunit of endolysosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/ATP6V0D1 row_index: 45 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral V-ATPase V0 subunit of endolysosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/ATP6V0D1 row_index: 46 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral V-ATPase V0 subunit of endolysosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/ATP6V0D2 row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral V-ATPase V0 subunit of endolysosomal and plasma membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/ATP6V1G1 row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral V-ATPase V1 subunit at the apical plasma membrane. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/ATRN row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane attractin isoform. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ATRN row_index: 12 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane attractin isoform. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/AZGP1 row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted zinc-alpha-2-glycoprotein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/AZGP1 row_index: 27 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted zinc-alpha-2-glycoprotein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/B4GALT1 row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Golgi galactosyltransferase whose long isoform has an evidenced cell-surface pool. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/B4GALT1 row_index: 47 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Golgi galactosyltransferase whose long isoform has an evidenced cell-surface pool. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/B4GALT1 row_index: 48 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Golgi galactosyltransferase whose long isoform has an evidenced cell-surface pool. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/BAIAP2 row_index: 77 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic membrane-deforming adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/BAIAP2 row_index: 78 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic membrane-deforming adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/BAIAP2L1 row_index: 24 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin-bundling adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/BAIAP2L1 row_index: 25 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin-bundling adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/BLVRA row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic biliverdin reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/BLVRA row_index: 29 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic biliverdin reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/C5orf46 row_index: 15 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted protein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/CA2 row_index: 86 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic carbonic anhydrase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CALM1 row_index: 89 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Calmodulin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CALM2 row_index: 66 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Calmodulin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CALM3 row_index: 89 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Calmodulin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CALR row_index: 115 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ER-lumen chaperone calreticulin; cell-surface pool by EXP (PMID:10358038). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/CAPG row_index: 34 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin-capping protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CAPG row_index: 35 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin-capping protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CAPG row_index: 36 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic actin-capping protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CD14 row_index: 137 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane receptor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/CD14 row_index: 138 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane receptor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/CD14 row_index: 139 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane receptor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/CD19 row_index: 37 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: B-cell plasma-membrane receptor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/CD48 row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane protein. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/CDH1 row_index: 156 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane E-cadherin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/CDK1 row_index: 177 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic and nuclear cell-cycle kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CHMP1A row_index: 82 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP2A row_index: 78 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP2A row_index: 79 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP2A row_index: 80 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP2B row_index: 85 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP2B row_index: 87 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP4B row_index: 111 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP4B row_index: 121 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP4B row_index: 123 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP5 row_index: 78 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP5 row_index: 79 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP5 row_index: 80 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP6 row_index: 73 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CHMP6 row_index: 74 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-III subunit acting on the cytosolic face of endosomes (as CHMP3 in pass 1). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/CKB row_index: 31 term: GO:0070062 extracellular exosome reference: PMID:11487543 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic creatine kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CKB row_index: 34 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic creatine kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CKB row_index: 36 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic creatine kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 97 term: GO:0070062 extracellular exosome reference: PMID:12519789 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 99 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 102 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 136 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 137 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 139 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CLTC row_index: 152 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Clathrin heavy chain on the cytoplasmic face of vesicle membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/COASY row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mainly cytosolic CoA synthase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/COMP row_index: 60 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted matrix protein with experimental heparin and proteoglycan binding (IDA). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/COPS8 row_index: 39 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear COP9 signalosome subunit. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CRISPLD1 row_index: 4 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted protein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/CRISPLD1 row_index: 6 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted protein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/CSK row_index: 80 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic tyrosine kinase with a lipid-raft pool. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/CUBN row_index: 40 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane endocytic receptor with no membrane span of its own, held at the surface by its transmembrane partner AMN (UniProt). Membrane proteins and their bound partners are expected EV contents (MISEV2018 (PMID:30637094) categories 1 and 2a). True, but not its core location. - gene: human/CUBN row_index: 43 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane endocytic receptor with no membrane span of its own, held at the surface by its transmembrane partner AMN (UniProt). Membrane proteins and their bound partners are expected EV contents (MISEV2018 (PMID:30637094) categories 1 and 2a). True, but not its core location. - gene: human/DDC row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic aromatic-L-amino-acid decarboxylase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/DNAJA2 row_index: 30 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic HSP40 co-chaperone, S-farnesylated (UniProt, PubMed:15308774). Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/DNAJB1 row_index: 65 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP40 co-chaperone. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/DNAJC13 row_index: 23 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Peripheral endosome-membrane protein. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/DNAJC3 row_index: 27 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-resident co-chaperone. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/DNAJC3 row_index: 30 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-resident co-chaperone. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/DPEP1 row_index: 32 term: GO:0070062 extracellular exosome reference: PMID:11487543 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored apical plasma-membrane dipeptidase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/DPEP1 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored apical plasma-membrane dipeptidase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/DPEP1 row_index: 34 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored apical plasma-membrane dipeptidase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/DPYS row_index: 12 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic dihydropyrimidinase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/DPYSL2 row_index: 34 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic microtubule-associated protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/EGF row_index: 221 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass membrane pro-EGF precursor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt membrane topology; compartment from GO); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/EGF row_index: 222 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass membrane pro-EGF precursor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt membrane topology; compartment from GO); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/EIF3E row_index: 50 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic translation initiation factor. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FAH row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic fumarylacetoacetase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FAH row_index: 12 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic fumarylacetoacetase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FAS row_index: 64 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane death receptor. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/FKBP4 row_index: 55 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic HSP90 co-chaperone. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FKBP4 row_index: 56 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic HSP90 co-chaperone. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FKBP5 row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP90 co-chaperone. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FN1 row_index: 174 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted fibronectin with experimental proteoglycan binding (IDA). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/FN1 row_index: 178 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted fibronectin with experimental proteoglycan binding (IDA). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/FN1 row_index: 179 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted fibronectin with experimental proteoglycan binding (IDA). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/FTH1 row_index: 45 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic ferritin heavy chain. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/FTH1 row_index: 47 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic ferritin heavy chain. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/G6PD row_index: 36 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glucose-6-phosphate dehydrogenase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/G6PD row_index: 39 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glucose-6-phosphate dehydrogenase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GALK1 row_index: 17 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic galactokinase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GALM row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic galactose mutarotase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GALNS row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal sulfatase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GAS6 row_index: 39 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted TAM-receptor ligand whose gamma-carboxylated Gla domain binds phosphatidylserine on membranes and vesicles. MISEV2018 (PMID:30637094) category 5 allows secreted proteins to associate with EVs through promiscuous lipid receptors on the EV surface, so the detection is plausible. (Confirms the existing KEEP_AS_NON_CORE.) - gene: human/GBA row_index: 81 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal glucocerebrosidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GBA1 row_index: 83 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal glucocerebrosidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GET3 row_index: 35 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic tail-anchored-protein targeting ATPase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GFPT1 row_index: 23 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glutamine-fructose-6-phosphate transaminase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GGT1 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane gamma-glutamyltransferase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/GGT1 row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane gamma-glutamyltransferase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/GLA row_index: 21 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal alpha-galactosidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GLB1 row_index: 40 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal beta-galactosidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GLB1 row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal beta-galactosidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GLIPR2 row_index: 5 term: GO:0070062 extracellular exosome reference: PMID:18570454 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Golgi-membrane protein. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/GLIPR2 row_index: 6 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Golgi-membrane protein. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/GLIPR2 row_index: 12 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Golgi-membrane protein. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/GLO1 row_index: 15 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glyoxalase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GLO1 row_index: 19 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glyoxalase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GLOD4 row_index: 3 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Mitochondrial glyoxalase-domain protein. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/GM2A row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: 'Lysosomal GM2 activator with experimental lipid chaperone activity (IDA, PMID:11707436, PMID:30988135): it extracts GM2 from intralysosomal luminal vesicle membranes, the precursors of exosomes. MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location.' - gene: human/GM2A row_index: 29 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: 'Lysosomal GM2 activator with experimental lipid chaperone activity (IDA, PMID:11707436, PMID:30988135): it extracts GM2 from intralysosomal luminal vesicle membranes, the precursors of exosomes. MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location.' - gene: human/GNS row_index: 21 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal sulfatase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GOT1 row_index: 39 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic aspartate aminotransferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GOT1 row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic aspartate aminotransferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GOT1 row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic aspartate aminotransferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GOT1 row_index: 43 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic aspartate aminotransferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GOT2 row_index: 19 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial aminotransferase; plasma-membrane pool by IDA (PMID:9537447). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/GOT2 row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial aminotransferase; plasma-membrane pool by IDA (PMID:9537447). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/GPI row_index: 49 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic glucose-6-phosphate isomerase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GPI row_index: 51 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic glucose-6-phosphate isomerase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GPI row_index: 52 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic glucose-6-phosphate isomerase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GPI row_index: 53 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic glucose-6-phosphate isomerase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GRB2 row_index: 943 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic signalling adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GRB2 row_index: 944 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic signalling adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GRB2 row_index: 945 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic signalling adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GSR row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Glutathione reductase, cytoplasmic isoform. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GSR row_index: 23 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Glutathione reductase, cytoplasmic isoform. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GSS row_index: 15 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glutathione synthetase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GSS row_index: 17 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic glutathione synthetase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/GUSB row_index: 24 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal beta-glucuronidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/GUSB row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal beta-glucuronidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HEXA row_index: 46 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal hexosaminidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HGD row_index: 10 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic homogentisate dioxygenase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HGD row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic homogentisate dioxygenase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HPD row_index: 27 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 4-hydroxyphenylpyruvate dioxygenase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HPRT1 row_index: 34 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic purine salvage enzyme. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HPX row_index: 17 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma hemopexin. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HPX row_index: 19 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma hemopexin. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HPX row_index: 20 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma hemopexin. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HSPA12A row_index: 9 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70-family protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA13 row_index: 18 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER/microsome HSP70-family protein. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/HSPA1B row_index: 82 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA1B row_index: 86 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA1B row_index: 87 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA1B row_index: 88 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA1B row_index: 141 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA1L row_index: 28 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA2 row_index: 48 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA2 row_index: 49 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA4 row_index: 25 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP110-family chaperone. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA6 row_index: 34 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA6 row_index: 35 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSP70. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/HSPA8 row_index: 169 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSC70, which also acts at endosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/HSPA8 row_index: 184 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSC70, which also acts at endosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/HSPA8 row_index: 198 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSC70, which also acts at endosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/HSPA8 row_index: 199 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSC70, which also acts at endosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/HSPA8 row_index: 201 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSC70, which also acts at endosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/HSPA8 row_index: 221 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic HSC70, which also acts at endosomal membranes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/HSPA9 row_index: 72 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Mitochondrial HSP70 (mortalin). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/HSPD1 row_index: 168 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial matrix HSP60; cell-surface pool by IDA (PMID:9243807, PMID:10663613, PMID:11807771, PMID:15784682). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/HSPD1 row_index: 169 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Mitochondrial matrix HSP60; cell-surface pool by IDA (PMID:9243807, PMID:10663613, PMID:11807771, PMID:15784682). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/HSPG2 row_index: 55 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted basement-membrane perlecan, itself a proteoglycan, with no recorded binding to EV-surface receptors. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HSPG2 row_index: 57 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted basement-membrane perlecan, itself a proteoglycan, with no recorded binding to EV-surface receptors. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HSPG2 row_index: 58 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted basement-membrane perlecan, itself a proteoglycan, with no recorded binding to EV-surface receptors. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/HSPG2 row_index: 68 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted basement-membrane perlecan, itself a proteoglycan, with no recorded binding to EV-surface receptors. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/IDUA row_index: 21 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal iduronidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/ITGB1 row_index: 321 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane integrin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ITGB1 row_index: 322 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane integrin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/ITIH1 row_index: 10 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted plasma inter-alpha-trypsin inhibitor heavy chain with experimental hyaluronan binding (GO:0005540, IDA, PMID:20463016). MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/ITIH1 row_index: 11 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted plasma inter-alpha-trypsin inhibitor heavy chain with experimental hyaluronan binding (GO:0005540, IDA, PMID:20463016). MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/ITIH2 row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted plasma inter-alpha-trypsin inhibitor heavy chain with experimental hyaluronan binding (GO:0005540, IDA, PMID:20463016). MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/ITIH2 row_index: 12 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted plasma inter-alpha-trypsin inhibitor heavy chain with experimental hyaluronan binding (GO:0005540, IDA, PMID:20463016). MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/ITIH2 row_index: 13 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted plasma inter-alpha-trypsin inhibitor heavy chain with experimental hyaluronan binding (GO:0005540, IDA, PMID:20463016). MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/ITIH3 row_index: 6 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma inter-alpha-trypsin inhibitor heavy chain. UniProt says only that it may carry hyaluronan, and unlike ITIH1 and ITIH2 it has no hyaluronan-binding annotation. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/ITIH4 row_index: 7 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma inter-alpha-trypsin inhibitor chain. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/ITIH4 row_index: 8 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma inter-alpha-trypsin inhibitor chain. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/ITIH4 row_index: 9 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma inter-alpha-trypsin inhibitor chain. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/KHK row_index: 14 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic ketohexokinase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/KL row_index: 88 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane klotho isoform. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/KL row_index: 89 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane klotho isoform. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/LAMP1 row_index: 60 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lysosome/endosome-membrane glycoprotein that also cycles to the plasma membrane. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/LAMP1 row_index: 69 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lysosome/endosome-membrane glycoprotein that also cycles to the plasma membrane. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/LCK row_index: 229 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored plasma-membrane kinase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/LFNG row_index: 25 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Golgi glycosyltransferase. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/LGALS3 row_index: 64 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic galectin secreted by a non-classical route. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/LGALS3 row_index: 94 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic galectin secreted by a non-classical route. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/LGALS3 row_index: 95 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic galectin secreted by a non-classical route. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/LOXL4 row_index: 20 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted lysyl oxidase-like enzyme. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/LPO row_index: 18 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted lactoperoxidase, with a basolateral plasma-membrane pool by IDA (PMID:19059195). Secreted or lumenal protein (UniProt) with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps. MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous receptors on the EV surface, and small EVs budding from the plasma membrane can carry a surface-bound pool, so the detection is plausible. True, but not its core location. - gene: human/LRG1 row_index: 37 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted plasma glycoprotein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/LRP2 row_index: 104 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane endocytic receptor (megalin). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/LRP2 row_index: 106 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane endocytic receptor (megalin). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/LRRK2 row_index: 334 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic kinase associated with vesicle and Golgi membranes. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/LYN row_index: 299 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored plasma-membrane kinase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/MAN1B1 row_index: 40 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-membrane mannosidase. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/MGP row_index: 18 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted matrix Gla protein. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/MTHFD1 row_index: 46 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic C1-tetrahydrofolate synthase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/MTHFD1 row_index: 48 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic C1-tetrahydrofolate synthase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/MTHFD1 row_index: 49 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic C1-tetrahydrofolate synthase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/MUC1 row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane mucin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/MUC1 row_index: 23 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane mucin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/MUC1 row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane mucin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/MUC1 row_index: 27 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Apical plasma-membrane mucin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/MVB12A row_index: 36 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/MVB12A row_index: 46 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/MVB12B row_index: 31 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/NAGLU row_index: 14 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal N-acetylglucosaminidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/NAGLU row_index: 16 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Lysosomal lumenal N-acetylglucosaminidase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/NAMPT row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear enzyme also released extracellularly. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NAMPT row_index: 27 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear enzyme also released extracellularly. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NAPRT row_index: 13 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic nicotinate phosphoribosyltransferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NAPRT row_index: 14 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic nicotinate phosphoribosyltransferase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NCSTN row_index: 77 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Gamma-secretase membrane subunit of the plasma membrane and endosomes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt membrane topology; compartment from GO); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NCSTN row_index: 79 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Gamma-secretase membrane subunit of the plasma membrane and endosomes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt membrane topology; compartment from GO); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NID1 row_index: 31 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted basement-membrane nidogen with experimental proteoglycan binding (IPI). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/NID1 row_index: 37 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Secreted basement-membrane nidogen with experimental proteoglycan binding (IPI). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/NME2 row_index: 62 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic nucleoside-diphosphate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NME2 row_index: 64 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic nucleoside-diphosphate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NME2 row_index: 65 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic nucleoside-diphosphate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NPHS2 row_index: 10 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Podocyte plasma-membrane podocin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NPHS2 row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Podocyte plasma-membrane podocin. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NQO2 row_index: 24 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic quinone reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NQO2 row_index: 25 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic quinone reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/NT5E row_index: 36 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane ecto-5'-nucleotidase (CD73). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NT5E row_index: 37 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane ecto-5'-nucleotidase (CD73). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NT5E row_index: 38 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane ecto-5'-nucleotidase (CD73). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/NT5E row_index: 43 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: GPI-anchored plasma-membrane ecto-5'-nucleotidase (CD73). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/P3H1 row_index: 32 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER prolyl 3-hydroxylase. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/P4HB row_index: 89 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ER-lumen protein disulfide isomerase; pool on the external side of the plasma membrane by IDA (PMID:21670307). Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs (category 4), but with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps; small EVs budding from the plasma membrane can carry that pool, so the detection is plausible. True, but not its core location. - gene: human/PAFAH1B1 row_index: 163 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic dynein regulator LIS1. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PARD6B row_index: 30 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic polarity adapter recruited to the plasma membrane. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/PCBD1 row_index: 32 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear pterin-4a-carbinolamine dehydratase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PCBD1 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear pterin-4a-carbinolamine dehydratase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PDCD5 row_index: 25 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear apoptosis regulator. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PDCD6IP row_index: 51 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: ACCEPT changed: true basis: 'ALIX itself works in EV biogenesis: UniProt records that it sorts multivesicular-body cargo into intralumenal vesicles and regulates exosome biogenesis with SDC1/4 and SDCBP (PubMed:22660413). This is a protein-specific call, not a MISEV category one: MISEV2018 (PMID:30637094) lists ALIX in category 2a together with TSG101 and the CHMPs.' - gene: human/PGK1 row_index: 45 term: GO:0070062 extracellular exosome reference: PMID:11487543 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PGK1 row_index: 47 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PGK1 row_index: 50 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PGK1 row_index: 51 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PGM1 row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic phosphoglucomutase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PGM1 row_index: 23 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic phosphoglucomutase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PHGDH row_index: 13 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate dehydrogenase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PHGDH row_index: 14 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate dehydrogenase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PHGDH row_index: 15 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate dehydrogenase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PHGDH row_index: 16 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoglycerate dehydrogenase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PI15 row_index: 4 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted protease inhibitor. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/PKLR row_index: 23 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic pyruvate kinase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 53 term: GO:0070062 extracellular exosome reference: PMID:12519789 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 54 term: GO:0070062 extracellular exosome reference: PMID:11487543 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 55 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 56 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 57 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 61 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 62 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 64 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PKM row_index: 67 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic pyruvate kinase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PLD3 row_index: 31 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass membrane protein of ER and endolysosomes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/PLD3 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass membrane protein of ER and endolysosomes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/PLD3 row_index: 34 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass membrane protein of ER and endolysosomes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/PM20D1 row_index: 30 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted N-fatty-acyl-amino-acid synthase/hydrolase. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/PNP row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic purine nucleoside phosphorylase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PNP row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic purine nucleoside phosphorylase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PNP row_index: 43 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic purine nucleoside phosphorylase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PPIB row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-lumen cyclophilin B. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/PPIB row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-lumen cyclophilin B. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/PPIB row_index: 42 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-lumen cyclophilin B. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/PPIB row_index: 44 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-lumen cyclophilin B. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/PPP2CA row_index: 141 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic PP2A catalytic subunit. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PPP2R1B row_index: 22 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic PP2A scaffold subunit. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PRDX4 row_index: 31 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-lumen peroxiredoxin. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/PRSS23 row_index: 5 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: Secreted serine protease. Secreted or lumenal protein (UniProt). MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous (proteoglycan, lipid) receptors on the EV surface, but asks that their identification be backed by evidence of that association. A bulk EV proteome cannot separate surface binding from co-isolation, and this protein's annotations record no experimental proteoglycan, heparin or lipid binding, and its own review keeps no experimental cell-surface or plasma-membrane pool. - gene: human/PSAP row_index: 62 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Prosaposin, lysosomal and secreted, with experimental phospholipid binding (IDA). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/PSAP row_index: 69 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Prosaposin, lysosomal and secreted, with experimental phospholipid binding (IDA). (Confirms the existing KEEP_AS_NON_CORE.) MISEV2018 (PMID:30637094) category 5 allows secreted proteins onto EVs through promiscuous (proteoglycan, lipid) receptors on the EV surface, so the detection is plausible. True, but not its core location. - gene: human/PSAT1 row_index: 15 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoserine aminotransferase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PSAT1 row_index: 16 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic phosphoserine aminotransferase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PSMA1 row_index: 173 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear proteasome subunit. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PSMA1 row_index: 175 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear proteasome subunit. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PSMA1 row_index: 176 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear proteasome subunit. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PSMB5 row_index: 140 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic/nuclear proteasome subunit. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/PTPRC row_index: 127 term: GO:0070062 extracellular exosome reference: PMID:12519789 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane phosphatase CD45. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/PTPRC row_index: 128 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane phosphatase CD45. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/QDPR row_index: 10 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic dihydropteridine reductase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/QDPR row_index: 11 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic dihydropteridine reductase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/QPRT row_index: 17 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic quinolinate phosphoribosyltransferase. Cytosolic protein (GO cytosol or cytoplasm annotation); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/RAB15 row_index: 16 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored small GTPase of the plasma membrane/endocytic system. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/RAB7A row_index: 89 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored late-endosome GTPase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/RAB7A row_index: 90 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored late-endosome GTPase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/RAB7A row_index: 91 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored late-endosome GTPase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/RAB9A row_index: 24 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored late-endosome GTPase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SCAMP2 row_index: 12 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Multi-pass membrane carrier of post-Golgi and endosomal recycling membranes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SLC3A2 row_index: 93 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane amino-acid transporter heavy chain (CD98). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SLC3A2 row_index: 96 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane amino-acid transporter heavy chain (CD98). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SLC3A2 row_index: 97 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane amino-acid transporter heavy chain (CD98). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SLC3A2 row_index: 100 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane amino-acid transporter heavy chain (CD98). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SMO row_index: 76 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane GPCR. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SMO row_index: 77 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane GPCR. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SMPD1 row_index: 95 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lysosomal lumenal acid sphingomyelinase, also secreted, with a plasma-membrane pool by IDA (PMID:20956541). Secreted or lumenal protein (UniProt) with an experimentally documented cell-surface or plasma-membrane pool that its own review keeps. MISEV2018 (PMID:30637094) category 5 allows such proteins onto EVs through specific or promiscuous receptors on the EV surface, and small EVs budding from the plasma membrane can carry a surface-bound pool, so the detection is plausible. True, but not its core location. - gene: human/SOD1 row_index: 80 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic superoxide dismutase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/SOD1 row_index: 85 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic superoxide dismutase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/SORL1 row_index: 157 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Single-pass sorting receptor of Golgi, endosome and plasma membranes. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SPR row_index: 8 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic sepiapterin reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/SPR row_index: 9 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic sepiapterin reductase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/SQSTM1 row_index: 248 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic autophagy cargo adapter. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/SRC row_index: 522 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored plasma-membrane kinase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SRC row_index: 523 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Lipid-anchored plasma-membrane kinase. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/SYPL1 row_index: 7 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Multi-pass membrane protein of cytoplasmic vesicles and melanosomes (UniProt). Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt membrane topology; compartment from GO); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/TALDO1 row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic transaldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TALDO1 row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic transaldolase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TFRC row_index: 129 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane transferrin receptor, a classic exosome cargo. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/TFRC row_index: 138 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane transferrin receptor, a classic exosome cargo. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/TFRC row_index: 141 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane transferrin receptor, a classic exosome cargo. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/TLN1 row_index: 80 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal talin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TLN1 row_index: 81 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal talin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TLN1 row_index: 82 term: GO:0070062 extracellular exosome reference: PMID:21362503 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal talin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TLN1 row_index: 83 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal talin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TNFAIP3 row_index: 95 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic ubiquitin-editing enzyme. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TNFSF10 row_index: 59 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Plasma-membrane TRAIL ligand. Transmembrane/lipid-anchored protein of the plasma membrane or endosomal system (UniProt); such proteins are expected EV contents (MISEV2018 (PMID:30637094) category 1). True, but not its core location. - gene: human/TPI1 row_index: 28 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic triosephosphate isomerase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TPI1 row_index: 33 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic triosephosphate isomerase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TPM3 row_index: 26 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal tropomyosin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TSG101 row_index: 91 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes; an EV marker protein, but its core location is the endosome. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/TSG101 row_index: 100 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes; an EV marker protein, but its core location is the endosome. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/TXN row_index: 57 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic thioredoxin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TXN row_index: 60 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic thioredoxin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TXN row_index: 61 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic thioredoxin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/TXNDC16 row_index: 6 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: MARK_AS_OVER_ANNOTATED changed: true basis: ER-lumen thioredoxin-domain protein. Mainly resident in an intracellular compartment that MISEV2018 (PMID:30637094) lists as not enriched in small EVs of plasma-membrane/endosomal origin (category 4), and its own review keeps no experimental cell-surface or plasma-membrane pool; an exosome annotation from a bulk EV proteome is not supported. - gene: human/UPB1 row_index: 20 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic beta-ureidopropionase. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VCL row_index: 98 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal vinculin at the cytoplasmic face of the plasma membrane. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VCL row_index: 99 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal vinculin at the cytoplasmic face of the plasma membrane. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VCL row_index: 103 term: GO:1903561 extracellular vesicle reference: PMID:24769233 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoskeletal vinculin at the cytoplasmic face of the plasma membrane. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VCP row_index: 202 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic AAA ATPase p97. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VCP row_index: 211 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic AAA ATPase p97. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VCP row_index: 214 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytosolic AAA ATPase p97. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/VPS28 row_index: 44 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS28 row_index: 50 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS28 row_index: 51 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS28 row_index: 52 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS37B row_index: 39 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS37B row_index: 41 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS37C row_index: 29 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS37C row_index: 30 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS37D row_index: 18 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/VPS37D row_index: 19 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: ESCRT-I subunit acting on the cytosolic face of endosomes. Cytosolic protein with lipid or membrane-protein binding ability; MISEV2018 (PMID:30637094) category 2a lists such proteins (ESCRT components, ALIX, annexins, HSPA8 and others) as expected EV contents. True, but not its core location. - gene: human/YWHAZ row_index: 174 term: GO:0031982 vesicle reference: PMID:19190083 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 14-3-3 protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/YWHAZ row_index: 181 term: GO:0070062 extracellular exosome reference: PMID:23533145 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 14-3-3 protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/YWHAZ row_index: 185 term: GO:0072562 blood microparticle reference: PMID:22516433 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 14-3-3 protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/YWHAZ row_index: 187 term: GO:0070062 extracellular exosome reference: PMID:19199708 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 14-3-3 protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/YWHAZ row_index: 188 term: GO:0070062 extracellular exosome reference: PMID:19056867 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 14-3-3 protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. - gene: human/YWHAZ row_index: 189 term: GO:0070062 extracellular exosome reference: PMID:20458337 previous_action: KEEP_AS_NON_CORE decision: KEEP_AS_NON_CORE changed: false basis: Cytoplasmic 14-3-3 protein. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location.