# Generated by build_dossiers.py -- review material only; decisions are in decisions_draft.py
- organism: human
  gene: A1BG
  row_index: 12
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Secreted.
  uniprot_function: ''
  uniprot_features: &id001
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id002
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:3458201
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-481007
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0031093 platelet alpha granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: A1BG
  row_index: 14
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Secreted.
  uniprot_function: ''
  uniprot_features: *id001
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id002
- organism: human
  gene: A1BG
  row_index: 15
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Secreted.
  uniprot_function: ''
  uniprot_features: *id001
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id002
- organism: human
  gene: A2M
  row_index: 13
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain the experimentally observed vesicle association, but do not treat it as a defining A2M localization.
    A2M is an abundant secreted protein, and proteomic recovery with extracellular vesicles does not by itself establish a
    vesicle-specific function.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:6203908}.
  uniprot_function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has
    a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase
    cleaves the bait region, a conformational change is induced in the pro ...
  uniprot_features: &id003
  - SIGNAL
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id004
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-1454781
    - TAS Reactome:R-HSA-158340
    - TAS Reactome:R-HSA-481007
  - term: GO:0031093 platelet alpha granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
- organism: human
  gene: A2M
  row_index: 15
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This is a valid high-throughput compartment association, but A2M is a highly abundant circulating soluble
    protein and the observation does not establish a microparticle-specific role. Retain it as non-core.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:6203908}.
  uniprot_function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has
    a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase
    cleaves the bait region, a conformational change is induced in the pro ...
  uniprot_features: *id003
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id004
- organism: human
  gene: A2M
  row_index: 17
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain the measured vesicle association as a context-specific localization. The source is an exosome proteome
    and the cached record is abstract-only; it does not establish a vesicle-specific A2M mechanism, so this should not be
    considered core.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:6203908}.
  uniprot_function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has
    a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase
    cleaves the bait region, a conformational change is induced in the pro ...
  uniprot_features: *id003
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id004
- organism: human
  gene: A2M
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA record supports an observed vesicle association in this cell culture context. It does not establish
    an exosome-specific A2M function, and abundant secreted proteins can accompany vesicle preparations, so the localization
    is non-core.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:6203908}.
  uniprot_function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has
    a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase
    cleaves the bait region, a conformational change is induced in the pro ...
  uniprot_features: *id003
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id004
- organism: human
  gene: A2ML1
  row_index: 2
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:16298998}.
  uniprot_function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has
    a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase
    cleaves the bait region, a conformational change is induced in the pro ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:16298998
    - IEA GO_REF:0000120
- organism: human
  gene: AASDHPPT
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA annotation derives from LC-MS/MS of 1,132 urinary-exosome proteins. Such detection is valid localization
    evidence for the sampled material, but it does not show selective exosome loading, secretion, or activity there. Cytosolic
    phosphopantetheinyl transfer remains the established core biology.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:12815048}.
  uniprot_function: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the
    4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as
    an acetyl thioester, to a serine residue of a broad range of acceptors includ ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:12815048
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-199202
- organism: human
  gene: ABHD8
  row_index: 13
  term: GO:0070062 extracellular exosome
  reference: PMID:18570454
  reference_title: Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow
    liquid chromatography-tandem mass spectrometry.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA annotation records ABHD8 detection in the human neural-stem-cell exosome proteome. Localization
    in an extracellular vesicle does not require the protein to have an exosomal effector function, and a main cytoplasmic
    pool does not exclude vesicle association. The available abstract does not independently resolve the individual peptide
    assignment, so retain the curated proteomic observation without claiming a core secretion mechanism.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:39225180}.
  uniprot_function: Negatively regulates NLRP3-driven inflammation (PubMed:39225180). Promotes NLRP3 degradation through the
    chaperone- mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting
    palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylat ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:39225180
    - IEA GO_REF:0000044
- organism: human
  gene: ACAT1
  row_index: 32
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain the reported localization with deference to the proteomics curator. The individual ACAT1 supplementary
    entry was not re-extracted, and the accessible paper text does not establish extracellular thiolase catalysis. This is
    a contextual detection; neither contamination nor biological irrelevance of the detected protein has been demonstrated.
  uniprot_subcellular_location: Mitochondrion {ECO:0000269|PubMed:1979337}.
  uniprot_function: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an
    aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free
    coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-o ...
  uniprot_features: &id005 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id006
  - term: GO:0005739 mitochondrion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:1979337
    - IEA GO_REF:0000120
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-70844
    - TAS Reactome:R-HSA-73916
    - TAS Reactome:R-HSA-74181
    - TAS Reactome:R-HSA-9838035
    - TAS Reactome:R-HSA-9838081
    - TAS Reactome:R-HSA-9838093
    - TAS Reactome:R-HSA-9838289
    - TAS Reactome:R-HSA-9854415
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IDA PMID:32944968
- organism: human
  gene: ACAT1
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain the reported localization with deference to the proteomics curator. The individual ACAT1 supplementary
    entry was not re-extracted, and the accessible paper text does not establish extracellular thiolase catalysis. This is
    a contextual detection; neither contamination nor biological irrelevance of the detected protein has been demonstrated.
  uniprot_subcellular_location: Mitochondrion {ECO:0000269|PubMed:1979337}.
  uniprot_function: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an
    aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free
    coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-o ...
  uniprot_features: *id005
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id006
- organism: human
  gene: ACTA2
  row_index: 43
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: PMID:23533145 characterizes extracellular vesicles from expressed prostatic secretions. The HDA annotation
    is a detection-level location statement; it does not establish a secretory route or a physiological extracellular actin
    mechanism. The exact ACTA2 peptide assignment was not independently re-extracted, and no contamination explanation is
    inferred solely from the intracellular core function.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton.
  uniprot_function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously
    expressed in all eukaryotic cells.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0001725 stress fiber
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005604 basement membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:11927518
    - IDA PMID:12355421
    - IDA PMID:17464107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-445699
    - TAS Reactome:R-HSA-445700
    - TAS Reactome:R-HSA-445704
    - TAS Reactome:R-HSA-445705
    - TAS Reactome:R-HSA-9604664
    - TAS Reactome:R-HSA-9914537
    - TAS Reactome:R-HSA-9934294
    - TAS Reactome:R-HSA-9934410
    - TAS Reactome:R-HSA-9934486
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0015629 actin cytoskeleton
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0030175 filopodium
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:18468998
  - term: GO:0044297 cell body
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
- organism: human
  gene: ACTB
  row_index: 214
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The full PMID:19190083 reports actin and associated cytoskeletal proteins in airway epithelial vesicle fractions
    with preparation controls. Retain the measured vesicle association as contextual, without calling it a constitutive secretion
    mechanism or contamination.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:17289661}. Nucleus
    {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:29925947}. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs. {ECO:0000269|PubMed:17289661}.
  uniprot_function: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks
    in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin)
    forms, both forms playing key functions, such as cell motility and  ...
  uniprot_features: &id007 []
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: &id008
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - NAS PMID:11078522
  - term: GO:0000785 chromatin
    qualifier: located_in
    evidence:
    - NAS PMID:12192000
    - NAS PMID:29374058
  - term: GO:0000786 nucleosome
    qualifier: part_of
    evidence:
    - IDA PMID:27153538
  - term: GO:0000930 gamma-tubulin complex
    qualifier: part_of
    evidence:
    - NAS PMID:39321809
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:11687588
    - IEA GO_REF:0000120
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5250947
    - TAS Reactome:R-HSA-5689544
    - TAS Reactome:R-HSA-9825847
    - TAS Reactome:R-HSA-9933236
    - TAS Reactome:R-HSA-9933237
    - TAS Reactome:R-HSA-9933238
    - TAS Reactome:R-HSA-9934021
    - TAS Reactome:R-HSA-9934024
    - TAS Reactome:R-NUL-4551334
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:24327345
    - IEA GO_REF:0000107
    - TAS PMID:16130169
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-1861595
    - TAS Reactome:R-HSA-2029466
    - TAS Reactome:R-HSA-2029473
    - TAS Reactome:R-HSA-2029476
    - TAS Reactome:R-HSA-203070
    - TAS Reactome:R-HSA-2197690
    - TAS Reactome:R-HSA-392751
    - TAS Reactome:R-HSA-3928595
    - TAS Reactome:R-HSA-430347
    - TAS Reactome:R-HSA-443779
    - TAS Reactome:R-HSA-445089
    - TAS Reactome:R-HSA-5218916
    - TAS Reactome:R-HSA-5626507
    - TAS Reactome:R-HSA-5665751
    - TAS Reactome:R-HSA-5665767
    - TAS Reactome:R-HSA-5665802
    - TAS Reactome:R-HSA-5665809
    - TAS Reactome:R-HSA-5665982
    - TAS Reactome:R-HSA-5666001
    - TAS Reactome:R-HSA-9666458
    - TAS Reactome:R-HSA-9914537
    - TAS Reactome:R-HSA-9934294
    - TAS Reactome:R-HSA-9934410
    - TAS Reactome:R-HSA-9934486
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IDA PMID:24327345
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS PMID:16130169
  - term: GO:0005869 dynactin complex
    qualifier: part_of
    evidence:
    - ISO GO_REF:0000114
  - term: GO:0005884 actin filament
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-3928654
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
  - term: GO:0005903 brush border
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IMP PMID:25753039
  - term: GO:0005912 adherens junction
    qualifier: located_in
    evidence:
    - IDA PMID:22855531
  - term: GO:0015629 actin cytoskeleton
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IDA PMID:11687588
  - term: GO:0016020 membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016363 nuclear matrix
    qualifier: located_in
    evidence:
    - NAS PMID:9128241
  - term: GO:0016514 SWI/SNF complex
    qualifier: part_of
    evidence:
    - NAS PMID:8804307
  - term: GO:0016586 RSC-type complex
    qualifier: part_of
    evidence:
    - NAS PMID:8804307
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IDA PMID:24415753
  - term: GO:0030424 axon
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0030863 cortical cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:11687588
    - IDA PMID:24415753
  - term: GO:0035060 brahma complex
    qualifier: part_of
    evidence:
    - NAS PMID:8804307
  - term: GO:0035267 NuA4 histone acetyltransferase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:10966108
    - IDA PMID:27153538
  - term: GO:0036464 cytoplasmic ribonucleoprotein granule
    qualifier: located_in
    evidence:
    - IDA PMID:15121898
  - term: GO:0043296 apical junction complex
    qualifier: located_in
    evidence:
    - IDA PMID:22855531
  - term: GO:0044305 calyx of Held
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0070160 tight junction
    qualifier: located_in
    evidence:
    - IDA PMID:22855531
  - term: GO:0071564 npBAF complex
    qualifier: part_of
    evidence:
    - NAS PMID:8804307
  - term: GO:0071565 nBAF complex
    qualifier: part_of
    evidence:
    - NAS PMID:17920018
  - term: GO:0097433 dense body
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0098685 Schaffer collateral - CA1 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098793 presynapse
    qualifier: located_in
    evidence:
    - TAS PMID:18331289
  - term: GO:0098871 postsynaptic actin cytoskeleton
    qualifier: is_active_in
    evidence:
    - IDA PMID:18341992
    - IMP PMID:18341992
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - EXP PMID:18341992
    - IDA PMID:18341992
    - IMP PMID:18341992
  - term: GO:0140092 bBAF complex
    qualifier: part_of
    evidence:
    - NAS PMID:12368262
  - term: GO:0140288 GBAF complex
    qualifier: part_of
    evidence:
    - NAS PMID:29374058
  - term: GO:1990904 ribonucleoprotein complex
    qualifier: part_of
    evidence:
    - IDA PMID:17289661
- organism: human
  gene: ACTB
  row_index: 235
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The full PMID:21362503 lists beta-actin among detected vesicle proteins and provides fraction characterization.
    Retain the measured extracellular-vesicle association as contextual, without claiming constitutive secretion or dismissing
    the detection as contamination.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:17289661}. Nucleus
    {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:29925947}. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs. {ECO:0000269|PubMed:17289661}.
  uniprot_function: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks
    in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin)
    forms, both forms playing key functions, such as cell motility and  ...
  uniprot_features: *id007
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id008
- organism: human
  gene: ADAM10
  row_index: 108
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Vesicle-associated extracellular pool; non-core localization.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:24990881,
    ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:33731436}; Single-pass
    type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894}; Single-pass type I membrane
    protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:12475894}. Cell projection, axon
    {ECO:0000250|UniProtKB:O35598}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35598}. Cell junction, adherens junction
    {E ...
  uniprot_function: Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins,
    including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis
    (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881,  ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - EXP PMID:12475894
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:30463011
    - IEA GO_REF:0000044
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8952289
    - TAS Reactome:R-HSA-9010074
    - TAS Reactome:R-HSA-9010113
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA PMID:12475894
  - term: GO:0005798 Golgi-associated vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:12475894
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:33731436
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:23676497
    - EXP PMID:24990881
    - EXP PMID:26686862
    - EXP PMID:29430990
    - EXP PMID:30463011
    - IDA GO_REF:0000052
    - IEA GO_REF:0000120
    - IMP PMID:20624979
    - IMP PMID:28164773
    - TAS Reactome:R-HSA-2220944
    - TAS Reactome:R-HSA-2220976
    - TAS Reactome:R-HSA-2666278
    - TAS Reactome:R-HSA-2730752
    - TAS Reactome:R-HSA-4224014
    - TAS Reactome:R-HSA-6798747
    - TAS Reactome:R-HSA-6799350
    - TAS Reactome:R-HSA-9010034
    - TAS Reactome:R-HSA-9010074
    - TAS Reactome:R-HSA-9013284
  - term: GO:0005912 adherens junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:12475894
    - IDA PMID:23035126
    - IDA PMID:23091066
    - IEA GO_REF:0000107
  - term: GO:0014069 postsynaptic density
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - NAS PMID:8694785
  - term: GO:0030136 clathrin-coated vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030425 dendrite
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0035579 specific granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6799350
  - term: GO:0046930 pore complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
    - IMP PMID:30463011
  - term: GO:0070821 tertiary granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798747
  - term: GO:0097038 perinuclear endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:23091066
  - term: GO:0097060 synaptic membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0097060 synaptic membrane
    qualifier: located_in
    evidence:
    - IDA PMID:23676497
    - IEA GO_REF:0000107
  - term: GO:0097197 tetraspanin-enriched microdomain
    qualifier: located_in
    evidence:
    - IDA PMID:23035126
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: ADIRF
  row_index: 6
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: 'The reference-projection test shows this PMID annotates 1046 distinct gene products with GO:0070062 and
    nothing else, all HDA, all assigned by UniProt. That is a bulk import, not 1046 independent findings; ADIRF is not mentioned
    anywhere in the paper''s narrative and the row derives from a supplementary identification list. One count I could not
    reconcile and am recording rather than explaining away: the paper''s text says close to 900 proteins were identified in
    the two pools, while GOA imported 1046 entities from it, and the identifications live in a supplemental table absent from
    the cached text. ADIRF''s presence outside the cell is independently real and better supported than the exosome-specific
    claim: it is measured in human serum by ELISA at microgram-per-millilitre concentrations across 139 patients (PMID:33737617)
    and detected as an intact protein by top-down mass spectrometry in lipoaspirate fluid (PMID:26719138). Neither is in GOA.
    That corroboration is why this row is kept rather than marked over-annotated. It supports the parent - GO:0070062 is a
    verified descendant of GO:0005576 extracellular region - and not the exosome mechanism, which requires release by multivesicular-body
    fusion and has never been tested for ADIRF. I did not propose GO:0005576 separately because this row already entails it.
    The protein has no signal peptide and no transmembrane segment, so the export route is unknown; that is filed as a knowledge
    gap.'
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:23239344}.
  uniprot_function: Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription
    initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression
    confers resistance to the anticancer chemotherapeutic drug cisplat ...
  uniprot_features: &id009 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id010
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:23239344
    - IEA GO_REF:0000120
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
- organism: human
  gene: ADIRF
  row_index: 7
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: 'This row''s value relative to the PMID:23533145 row is that the source material is healthy-donor urine,
    so the contaminating-tumour-protein caveat that the other paper raises about itself does not apply here. Against that,
    the paper is cached abstract-only (full_text_available: false), so I can characterise only what the abstract states, and
    the reference-projection test shows it annotates 1016 distinct gene products with GO:0070062 and no other term - a bulk
    import. ADIRF is a small, very abundant protein and both exosome preparations are from the urogenital tract where ADIRF
    is well expressed, so detection is expected on abundance grounds alone. ADIRF''s presence outside the cell is independently
    real and better supported than the exosome-specific claim: it is measured in human serum by ELISA at microgram-per-millilitre
    concentrations across 139 patients (PMID:33737617) and detected as an intact protein by top-down mass spectrometry in
    lipoaspirate fluid (PMID:26719138). Neither is in GOA. That corroboration is why this row is kept rather than marked over-annotated.
    It supports the parent - GO:0070062 is a verified descendant of GO:0005576 extracellular region - and not the exosome
    mechanism, which requires release by multivesicular-body fusion and has never been tested for ADIRF. I did not propose
    GO:0005576 separately because this row already entails it. The protein has no signal peptide and no transmembrane segment,
    so the export route is unknown; that is filed as a knowledge gap.'
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:23239344}.
  uniprot_function: Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription
    initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression
    confers resistance to the anticancer chemotherapeutic drug cisplat ...
  uniprot_features: *id009
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id010
- organism: human
  gene: AGRN
  row_index: 80
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The source describes proteomic analysis of expressed prostatic secretions in urine. Retain the curator-supported
    fraction association as non-core; the available extraction does not resolve the AGRN peptide/vesicle-topology details.
    It does not support an agrin-specific vesicle-biogenesis activity, but lack of that activity is not evidence that detection
    was contamination.
  uniprot_subcellular_location: '[Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
    Note=Synaptic basal lamina at the neuromuscular junction. {ECO:0000250|UniProtKB:P31696}. [Isoform 2]: Synapse {ECO:0000250|UniProtKB:A2ASQ1}.
    Cell membrane {ECO:0000250|UniProtKB:A2ASQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A2ASQ1}.'
  uniprot_function: '[Isoform 1]: Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and
    the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component
    of the AGRN-LRP4 receptor complex that induces the phosphorylation and activatio ...'
  uniprot_features: &id011
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id012
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-2467665
    - TAS Reactome:R-HSA-9914537
    - TAS Reactome:R-NUL-2467431
  - term: GO:0005604 basement membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005604 basement membrane
    qualifier: located_in
    evidence:
    - IDA PMID:9405491
    - IEA GO_REF:0000120
  - term: GO:0005796 Golgi lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1667005
    - TAS Reactome:R-HSA-1878002
    - TAS Reactome:R-HSA-1889955
    - TAS Reactome:R-HSA-1889978
    - TAS Reactome:R-HSA-1889981
    - TAS Reactome:R-HSA-2022851
    - TAS Reactome:R-HSA-2022856
    - TAS Reactome:R-HSA-2022860
    - TAS Reactome:R-HSA-2022887
    - TAS Reactome:R-HSA-2024108
    - TAS Reactome:R-HSA-2076383
    - TAS Reactome:R-HSA-2076392
    - TAS Reactome:R-HSA-2076419
    - TAS Reactome:R-HSA-2076508
    - TAS Reactome:R-HSA-2076611
    - TAS Reactome:R-HSA-3560802
    - TAS Reactome:R-HSA-3560804
    - TAS Reactome:R-HSA-3656254
    - TAS Reactome:R-HSA-3656257
    - TAS Reactome:R-HSA-3656261
    - TAS Reactome:R-HSA-3656267
    - TAS Reactome:R-HSA-4420365
    - TAS Reactome:R-HSA-9036285
    - TAS Reactome:R-HSA-9036289
    - TAS Reactome:R-HSA-9940993
    - TAS Reactome:R-HSA-9941039
    - TAS Reactome:R-HSA-9953259
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1678694
    - TAS Reactome:R-HSA-2024084
    - TAS Reactome:R-HSA-2024108
    - TAS Reactome:R-HSA-2404131
    - TAS Reactome:R-HSA-2423785
    - TAS Reactome:R-HSA-2429643
    - TAS Reactome:R-HSA-9694579
    - TAS Reactome:R-HSA-9694661
    - TAS Reactome:R-HSA-9698988
    - TAS Reactome:R-HSA-9699007
    - TAS Reactome:R-HSA-9836899
  - term: GO:0031012 extracellular matrix
    qualifier: colocalizes_with
    evidence:
    - TAS PMID:22261194
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IDA PMID:17628813
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1667005
    - TAS Reactome:R-HSA-2024084
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045202 synapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
- organism: human
  gene: AGRN
  row_index: 81
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The source describes proteomic analysis of human parotid saliva. Retain the curator-supported fraction association
    as non-core; the available extraction does not resolve the AGRN peptide/vesicle-topology details. It does not support
    an agrin-specific vesicle-biogenesis activity, but lack of that activity is not evidence that detection was contamination.
  uniprot_subcellular_location: '[Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
    Note=Synaptic basal lamina at the neuromuscular junction. {ECO:0000250|UniProtKB:P31696}. [Isoform 2]: Synapse {ECO:0000250|UniProtKB:A2ASQ1}.
    Cell membrane {ECO:0000250|UniProtKB:A2ASQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A2ASQ1}.'
  uniprot_function: '[Isoform 1]: Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and
    the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component
    of the AGRN-LRP4 receptor complex that induces the phosphorylation and activatio ...'
  uniprot_features: *id011
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id012
- organism: human
  gene: AGRN
  row_index: 82
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The source describes proteomic analysis of B-cell-derived exosomes. Retain the curator-supported fraction
    association as non-core; the available extraction does not resolve the AGRN peptide/vesicle-topology details. It does
    not support an agrin-specific vesicle-biogenesis activity, but lack of that activity is not evidence that detection was
    contamination.
  uniprot_subcellular_location: '[Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
    Note=Synaptic basal lamina at the neuromuscular junction. {ECO:0000250|UniProtKB:P31696}. [Isoform 2]: Synapse {ECO:0000250|UniProtKB:A2ASQ1}.
    Cell membrane {ECO:0000250|UniProtKB:A2ASQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A2ASQ1}.'
  uniprot_function: '[Isoform 1]: Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and
    the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component
    of the AGRN-LRP4 receptor complex that induces the phosphorylation and activatio ...'
  uniprot_features: *id011
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id012
- organism: human
  gene: AHCY
  row_index: 21
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The externally recovered primary PMC2637050 Table 1 identifies AHCY with 10 unique peptides and 28 spectra
    (Pep and ID columns, respectively). The study profiled a low-density urinary membrane fraction consisting chiefly of exosomes.
    Retain the source-level detection as a contextual compartment; it does not establish an extracellular catalytic role or
    participation in exosome biogenesis.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus
    {ECO:0000269|PubMed:28647132}. Endoplasmic reticulum {ECO:0000269|PubMed:28647132}. Note=Identified by mass spectrometry
    in melanosome fractions from stage I to stage IV.
  uniprot_function: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798).
    Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}.
  uniprot_features: []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:28647132
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - EXP PMID:28647132
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-174401
    - TAS Reactome:R-HSA-5579084
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: AHNAK
  row_index: 59
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A second independent human exosome proteome. Same reasoning as the parotid row.
  uniprot_subcellular_location: Nucleus.
  uniprot_function: May be required for neuronal cell differentiation.
  uniprot_features: &id013 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id014
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS PMID:21940993
    - NAS PMID:1608957
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:22057634
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000107
    - ISS PMID:21940993
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:21940993
    - IDA PMID:22057634
    - IDA PMID:3126079
    - IEA GO_REF:0000117
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IDA PMID:21940993
  - term: GO:0030315 T-tubule
    qualifier: located_in
    evidence:
    - NAS PMID:17185750
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:21940993
  - term: GO:0042383 sarcolemma
    qualifier: located_in
    evidence:
    - IDA PMID:22057634
    - NAS PMID:17185750
  - term: GO:0043034 costamere
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS PMID:21940993
  - term: GO:0044291 cell-cell contact zone
    qualifier: located_in
    evidence:
    - IDA PMID:21940993
  - term: GO:0045121 membrane raft
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:14699089
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:22057634
  - term: GO:0098797 plasma membrane protein complex
    qualifier: part_of
    evidence:
    - IPI PMID:23275167
- organism: human
  gene: AHNAK
  row_index: 60
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A mass-spectrometry catalogue of human exosomes. Consistent with the human-myotube IDA and with AHNAK being
    the dominant protein of carcinoma extracellular vesicles, so this is corroboration rather than noise - but it remains
    a cargo observation.
  uniprot_subcellular_location: Nucleus.
  uniprot_function: May be required for neuronal cell differentiation.
  uniprot_features: *id013
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id014
- organism: human
  gene: AHSA1
  row_index: 29
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: AHSA1 was detected in urinary exosomes by mass spectrometry (PMID:19056867). While the detection is real,
    exosome localization is not a core function or localization of AHSA1. Many abundant cytoplasmic proteins are detected
    in exosome proteomics studies. This is a minor, non-functional localization.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:11554768}. Endoplasmic reticulum {ECO:0000269|PubMed:11554768}.
    Note=May transiently interact with the endoplasmic reticulum.
  uniprot_function: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading
    to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co- chaperone FNIP1 for binding
    to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoni ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
- organism: human
  gene: AKR1C4
  row_index: 54
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: PMID:23533145 isolates urinary extracellular vesicle preparations and characterizes their proteome. The
    HDA source is a compartment observation, not a claim that AKR1C4 has an extracellular catalytic role. Its established
    cytosolic pool does not exclude vesicle-associated detection; generic concerns about contamination are not target-specific
    contrary evidence. Retain with the limits of high-throughput proteomic localization.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04828}.
  uniprot_function: Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids.
    Displays broad substrate specificity with distinct positional and stereochemistry, primarily generating 3alpha/beta-,
    17beta- and 20alpha-hydroxysteroids (PubMed:10634139, PubMed:10998348, PubM ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:2187532
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-192036
    - TAS Reactome:R-HSA-192160
    - TAS Reactome:R-HSA-193758
    - TAS Reactome:R-HSA-193781
    - TAS Reactome:R-HSA-193800
    - TAS Reactome:R-HSA-193841
    - TAS Reactome:R-HSA-2855252
- organism: human
  gene: ALAD
  row_index: 53
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Bystander localization of an abundant cytosolic protein in exosome proteomes; not a core function. Retained
    per curation policy for experimental HDA localizations.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P10518}.
  uniprot_function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate
    per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. {ECO:0000269|PubMed:11032836,
    ECO:0000269|PubMed:19812033}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-189439
    - TAS Reactome:R-HSA-190141
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: ALCAM
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomic survey detection, consistent with a surface glycoprotein that is shed and packaged into vesicles,
    but not a characterized site of function.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806,
    ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:24740813, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}; Single-pass
    type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite
    {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting
    dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunol
    ...
  uniprot_function: Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6,
    as well as homotypic cell- cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728,
    PubMed:7760007). Promotes T-cell activation and proliferation via its ...
  uniprot_features: &id015
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id016
  - term: GO:0001772 immunological synapse
    qualifier: located_in
    evidence:
    - IDA PMID:15294938
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:15496415
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:15048703
    - EXP PMID:16352806
    - EXP PMID:23169771
    - EXP PMID:24740813
    - EXP PMID:24945728
    - EXP PMID:7760007
    - IDA PMID:15294938
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0030425 dendrite
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0042101 T cell receptor complex
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:15294938
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: ALCAM
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomic survey detection, consistent with a surface glycoprotein that is shed and packaged into vesicles,
    but not a characterized site of function.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806,
    ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:24740813, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}; Single-pass
    type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite
    {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting
    dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunol
    ...
  uniprot_function: Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6,
    as well as homotypic cell- cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728,
    PubMed:7760007). Promotes T-cell activation and proliferation via its ...
  uniprot_features: *id015
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id016
- organism: human
  gene: ALDOA
  row_index: 32
  term: GO:0070062 extracellular exosome
  reference: PMID:12519789
  reference_title: Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function
    and multivesicular body formation.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Bystander localization in exosome proteomics; not the core cytosolic site of function.
  uniprot_subcellular_location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril,
    sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the
    I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
  uniprot_function: Catalyzes the reversible conversion of beta-D-fructose 1,6- bisphosphate (FBP) into two triose phosphate
    and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding
    protein (By similarity). In response to glucose deprivation, FBP dissociates ...
  uniprot_features: &id017 []
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: &id018
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
    - TAS Reactome:R-HSA-6798745
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-71495
    - TAS Reactome:R-HSA-71496
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IDA PMID:9244396
  - term: GO:0031093 platelet alpha granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
  - term: GO:0031430 M band
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031674 I band
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS PMID:1008835
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0061827 sperm head
    qualifier: located_in
    evidence:
    - IDA PMID:23355646
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:17641064
  - term: GO:1904724 tertiary granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: ALDOA
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome-proteomics bystander detection; non-core.
  uniprot_subcellular_location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril,
    sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the
    I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
  uniprot_function: Catalyzes the reversible conversion of beta-D-fructose 1,6- bisphosphate (FBP) into two triose phosphate
    and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding
    protein (By similarity). In response to glucose deprivation, FBP dissociates ...
  uniprot_features: *id017
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id018
- organism: human
  gene: ALDOA
  row_index: 38
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome-proteomics bystander detection; non-core.
  uniprot_subcellular_location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril,
    sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the
    I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
  uniprot_function: Catalyzes the reversible conversion of beta-D-fructose 1,6- bisphosphate (FBP) into two triose phosphate
    and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding
    protein (By similarity). In response to glucose deprivation, FBP dissociates ...
  uniprot_features: *id017
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id018
- organism: human
  gene: ALDOA
  row_index: 39
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome-proteomics bystander detection; non-core.
  uniprot_subcellular_location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril,
    sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the
    I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
  uniprot_function: Catalyzes the reversible conversion of beta-D-fructose 1,6- bisphosphate (FBP) into two triose phosphate
    and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding
    protein (By similarity). In response to glucose deprivation, FBP dissociates ...
  uniprot_features: *id017
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id018
- organism: human
  gene: ALDOA
  row_index: 40
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome-proteomics bystander detection; non-core.
  uniprot_subcellular_location: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril,
    sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the
    I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
  uniprot_function: Catalyzes the reversible conversion of beta-D-fructose 1,6- bisphosphate (FBP) into two triose phosphate
    and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding
    protein (By similarity). In response to glucose deprivation, FBP dissociates ...
  uniprot_features: *id017
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id018
- organism: human
  gene: ALPL
  row_index: 67
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Externally indexed full PMID:19056867/PMC2637050 Table 1 explicitly lists ALPL tissue-nonspecific alkaline-phosphatase
    precursor with three unique peptides and four identifications. This resolves the target hit despite the abstract-only
    local cache. Preserve the positive contextual localization; the study does not establish TNAP catalysis or exosome biogenesis
    in that fraction.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064,
    ECO:0000269|PubMed:33821301}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064}. Extracellular
    vesicle membrane {ECO:0000250|UniProtKB:P09242}; Lipid- anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion
    membrane {ECO:0000250|UniProtKB:P09242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P09242}. Mitochondrion intermembrane
    space {ECO:0000250|UniProtKB:P09242}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles
    (MVs ...
  uniprot_function: 'Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization
    and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). Has broad substrate specificity and can
    hydrolyze a considerable variety of compounds: however, only a few ...'
  uniprot_features:
  - LIPID
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-8940388
  - term: GO:0005758 mitochondrial intermembrane space
    qualifier: is_active_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005758 mitochondrial intermembrane space
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:2220817
    - IDA PMID:33821301
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:23688511
    - EXP PMID:25982064
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-8940388
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031966 mitochondrial membrane
    qualifier: is_active_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0031966 mitochondrial membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0065010 extracellular membrane-bounded organelle
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
- organism: human
  gene: AMN
  row_index: 30
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic detection in urinary exosomes is consistent with AMN's apical renal-epithelial expression but
    is a peripheral/incidental localization, not its functional site.
  uniprot_subcellular_location: '[Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:14576052}; Single-pass type I membrane
    protein {ECO:0000305|PubMed:30523278}. Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278};
    Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305|PubMed:14576052}. Membrane, coated pit
    {ECO:0000305|PubMed:14576052}. [Soluble protein amnionless]: Secreted {ECO:0000269|PubMed:14576052}.'
  uniprot_function: Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:14576052, PubMed:29402915,
    PubMed:30523278). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:14576052, PubMed:29402915).
    The complex formed by AMN and CUBN is required for efficient a ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:14576052
    - EXP PMID:29402915
    - EXP PMID:30523278
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-264834
    - TAS Reactome:R-HSA-264848
    - TAS Reactome:R-HSA-3000103
    - TAS Reactome:R-HSA-3000137
    - TAS Reactome:R-HSA-3296462
    - TAS Reactome:R-HSA-3296477
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000044
  - term: GO:0016324 apical plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000044
    - NAS PMID:14576052
  - term: GO:0030139 endocytic vesicle
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0030139 endocytic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000107
  - term: GO:0031526 brush border membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031528 microvillus membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:14576052
  - term: GO:0031528 microvillus membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043235 signaling receptor complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IPI PMID:30523278
- organism: human
  gene: ANKFY1
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:18570454
  reference_title: Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow
    liquid chromatography-tandem mass spectrometry.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The exosome rows may reflect proteomic detection, but they do not explain the core Rab5/PI3P/endosomal trafficking
    and ATG2A autophagosome-assembly roles.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:10940552}. Endosome membrane {ECO:0000269|PubMed:10940552};
    Peripheral membrane protein {ECO:0000269|PubMed:10940552}. Early endosome {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051,
    ECO:0000269|PubMed:29959197}. Note=Also associated with endosomal membranes. Localizes to macropinosomes (PubMed:15328530).
    On endosomes, partially colocalizes with components of the retromer (PubMed:22284051). {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051}.
  uniprot_function: Proposed effector of Rab5 (PubMed:15328530). Binds to phosphatidylinositol 3-phosphate (PI[3]P) (PubMed:15328530).
    Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with
    early endosomes (PubMed:15328530). Involved in macropinocytosis ...
  uniprot_features: &id019 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id020
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:10940552
    - IEA GO_REF:0000044
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000117
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - EXP PMID:22284051
    - EXP PMID:29959197
    - IDA PMID:15328530
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0010008 endosome membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:10940552
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-9013438
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:10940552
    - IEA GO_REF:0000117
  - term: GO:0030904 retromer complex
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:22284051
  - term: GO:0044354 macropinosome
    qualifier: located_in
    evidence:
    - IDA PMID:15328530
- organism: human
  gene: ANKFY1
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The exosome rows may reflect proteomic detection, but they do not explain the core Rab5/PI3P/endosomal trafficking
    and ATG2A autophagosome-assembly roles.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:10940552}. Endosome membrane {ECO:0000269|PubMed:10940552};
    Peripheral membrane protein {ECO:0000269|PubMed:10940552}. Early endosome {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051,
    ECO:0000269|PubMed:29959197}. Note=Also associated with endosomal membranes. Localizes to macropinosomes (PubMed:15328530).
    On endosomes, partially colocalizes with components of the retromer (PubMed:22284051). {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051}.
  uniprot_function: Proposed effector of Rab5 (PubMed:15328530). Binds to phosphatidylinositol 3-phosphate (PI[3]P) (PubMed:15328530).
    Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with
    early endosomes (PubMed:15328530). Involved in macropinocytosis ...
  uniprot_features: *id019
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id020
- organism: human
  gene: APLP2
  row_index: 40
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:8485127 "It is 763 amino acids in length and appears to encode a signal peptide, a large apparent
    extracellular domain including a Kunitz inhibitor domain, a transmembrane region, and a short cytoplasmic domain."]'
  uniprot_subcellular_location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.
  uniprot_function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards
    coagulation factors. May interact with cellular G protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI
    box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glan ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:7702756
    - IEA GO_REF:0000044
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8952289
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-481044
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - NAS PMID:8485127
  - term: GO:0031091 platelet alpha granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0031092 platelet alpha granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481044
- organism: human
  gene: APOE
  row_index: 191
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This location is real and biologically useful, but it is secondary to APOE's core secreted lipoprotein-particle
    role.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:2498325, ECO:0000269|PubMed:30333625}. Secreted, extracellular
    space {ECO:0000269|PubMed:8340399}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9488694}.
    Extracellular vesicle {ECO:0000269|PubMed:26387950}. Endosome, multivesicular body {ECO:0000269|PubMed:26387950}. Note=In
    the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868,
    PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate
    proteoglycans-dependent m ...
  uniprot_function: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated
    lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692).
    APOE is a core component of plasma lipoproteins and is involve ...
  uniprot_features: &id021
  - SIGNAL
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: &id022
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:2498325
    - EXP PMID:30333625
    - IDA PMID:16805831
    - IDA PMID:8089103
    - IDA PMID:8340399
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-174657
    - TAS Reactome:R-HSA-174660
    - TAS Reactome:R-HSA-174690
    - TAS Reactome:R-HSA-174739
    - TAS Reactome:R-HSA-174757
    - TAS Reactome:R-HSA-2395768
    - TAS Reactome:R-HSA-2395784
    - TAS Reactome:R-HSA-2404131
    - TAS Reactome:R-HSA-2423785
    - TAS Reactome:R-HSA-2507854
    - TAS Reactome:R-HSA-266303
    - TAS Reactome:R-HSA-8869590
    - TAS Reactome:R-HSA-9031512
    - TAS Reactome:R-HSA-9612243
    - TAS Reactome:R-HSA-976734
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - NAS PMID:8083695
    - TAS PMID:9622609
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2404131
    - TAS Reactome:R-HSA-2404140
    - TAS Reactome:R-HSA-2429643
  - term: GO:0005771 multivesicular body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:25122793
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8952289
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA PMID:25122793
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-174657
    - TAS Reactome:R-HSA-174706
  - term: GO:0030425 dendrite
    qualifier: located_in
    evidence:
    - NAS PMID:8083695
  - term: GO:0030669 clathrin-coated endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-174706
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IDA PMID:9488694
  - term: GO:0034360 chylomicron remnant
    qualifier: part_of
    evidence:
    - IDA PMID:7683668
  - term: GO:0034361 very-low-density lipoprotein particle
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:17154273
    - IDA PMID:22138302
    - IDA PMID:2280190
    - IDA PMID:7683668
    - IDA PMID:8071364
    - IDA PMID:8245722
    - IDA PMID:9211985
  - term: GO:0034362 low-density lipoprotein particle
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:22138302
    - IDA PMID:2280190
    - IDA PMID:8245722
    - IDA PMID:9211985
    - IEA GO_REF:0000120
  - term: GO:0034363 intermediate-density lipoprotein particle
    qualifier: part_of
    evidence:
    - IDA PMID:17336988
    - IDA PMID:22138302
    - IDA PMID:2280190
    - IDA PMID:9211985
  - term: GO:0034364 high-density lipoprotein particle
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:14754908
    - IDA PMID:210174
    - IDA PMID:22138302
    - IDA PMID:2280190
    - IDA PMID:8071364
    - IDA PMID:9211985
  - term: GO:0034365 discoidal high-density lipoprotein particle
    qualifier: part_of
    evidence:
    - TAS PMID:22383525
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IDA PMID:26387950
  - term: GO:0042627 chylomicron
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:16935699
    - IDA PMID:8245722
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - NAS PMID:8083695
  - term: GO:0043083 synaptic cleft
    qualifier: is_active_in
    evidence:
    - IDA PMID:22637583
    - IEP PMID:22637583
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:26387950
  - term: GO:0071682 endocytic vesicle lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2507854
  - term: GO:0097487 multivesicular body, internal vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:26387950
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IDA PMID:22637583
    - IEA GO_REF:0000107
    - IEP PMID:22637583
  - term: GO:1903561 extracellular vesicle
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:1903561 extracellular vesicle
    qualifier: located_in
    evidence:
    - EXP PMID:26387950
    - IEA GO_REF:0000044
  - term: GO:1990777 lipoprotein particle
    qualifier: part_of
    evidence:
    - IDA PMID:22138302
- organism: human
  gene: APOE
  row_index: 194
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This location is real and biologically useful, but it is secondary to APOE's core secreted lipoprotein-particle
    role.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:2498325, ECO:0000269|PubMed:30333625}. Secreted, extracellular
    space {ECO:0000269|PubMed:8340399}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9488694}.
    Extracellular vesicle {ECO:0000269|PubMed:26387950}. Endosome, multivesicular body {ECO:0000269|PubMed:26387950}. Note=In
    the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868,
    PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate
    proteoglycans-dependent m ...
  uniprot_function: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated
    lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692).
    APOE is a core component of plasma lipoproteins and is involve ...
  uniprot_features: *id021
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id022
- organism: human
  gene: APOE
  row_index: 210
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This location is real and biologically useful, but it is secondary to APOE's core secreted lipoprotein-particle
    role.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:2498325, ECO:0000269|PubMed:30333625}. Secreted, extracellular
    space {ECO:0000269|PubMed:8340399}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9488694}.
    Extracellular vesicle {ECO:0000269|PubMed:26387950}. Endosome, multivesicular body {ECO:0000269|PubMed:26387950}. Note=In
    the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868,
    PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate
    proteoglycans-dependent m ...
  uniprot_function: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated
    lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692).
    APOE is a core component of plasma lipoproteins and is involve ...
  uniprot_features: *id021
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id022
- organism: human
  gene: APOE
  row_index: 211
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This location is real and biologically useful, but it is secondary to APOE's core secreted lipoprotein-particle
    role.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:2498325, ECO:0000269|PubMed:30333625}. Secreted, extracellular
    space {ECO:0000269|PubMed:8340399}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9488694}.
    Extracellular vesicle {ECO:0000269|PubMed:26387950}. Endosome, multivesicular body {ECO:0000269|PubMed:26387950}. Note=In
    the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868,
    PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate
    proteoglycans-dependent m ...
  uniprot_function: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated
    lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692).
    APOE is a core component of plasma lipoproteins and is involve ...
  uniprot_features: *id021
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id022
- organism: human
  gene: APOH
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:23533145 "In pooled EPS-urine exosome samples, ~900 proteins were detected."]'
  uniprot_subcellular_location: Secreted.
  uniprot_function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate.
    May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged
    cells.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:15486070
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-481009
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:16480936
  - term: GO:0031089 platelet dense granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481009
  - term: GO:0034361 very-low-density lipoprotein particle
    qualifier: part_of
    evidence:
    - IDA PMID:222615
  - term: GO:0034364 high-density lipoprotein particle
    qualifier: part_of
    evidence:
    - IDA PMID:222615
  - term: GO:0042627 chylomicron
    qualifier: part_of
    evidence:
    - IDA PMID:222615
- organism: human
  gene: ARL15
  row_index: 9
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:37449820 "Both wild-type ARL15 and the R95A mutant localize to the plasma membrane as well as internal
    structures."] [PMID:35834310 "In addition to the Golgi, WT and AL-mutant Arl15-GFP were also detected at the plasma membrane
    (PM), early endosome (EE), late endosome (LE), and lysosome"]'
  uniprot_subcellular_location: ''
  uniprot_function: ''
  uniprot_features: &id023 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id024 []
- organism: human
  gene: ARL15
  row_index: 10
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:37449820 "Both wild-type ARL15 and the R95A mutant localize to the plasma membrane as well as internal
    structures."] [PMID:35834310 "In addition to the Golgi, WT and AL-mutant Arl15-GFP were also detected at the plasma membrane
    (PM), early endosome (EE), late endosome (LE), and lysosome"]'
  uniprot_subcellular_location: ''
  uniprot_function: ''
  uniprot_features: *id023
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id024
- organism: human
  gene: ARMC3
  row_index: 3
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:19056867 "Here, we used LC-MS/MS to profile the proteome of human urinary exosomes."]'
  uniprot_subcellular_location: ''
  uniprot_function: Essential for male fertility and sperm motility (By similarity). During spermatogenesis, promotes the
    autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar
    motility (PubMed:34428398). {ECO:0000250|UniProtKB:A2AU72, ECO:0000269|Pu ...
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads: []
- organism: human
  gene: ARPC4
  row_index: 60
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:19056867 "Here, we used LC-MS/MS to profile the proteome of human urinary exosomes."]'
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9359840}.
    Nucleus {ECO:0000269|PubMed:29925947}.
  uniprot_function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization
    upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched
    actin networks in the cytoplasm, providing the force for cell motilit ...
  uniprot_features: &id025 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id026
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:29925947
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1861595
    - TAS Reactome:R-HSA-2029466
    - TAS Reactome:R-HSA-2029473
    - TAS Reactome:R-HSA-2029476
    - TAS Reactome:R-HSA-2197690
    - TAS Reactome:R-HSA-3928595
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
    - TAS Reactome:R-HSA-9666458
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005885 Arp2/3 protein complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:11162547
    - IDA PMID:11741539
    - IEA GO_REF:0000002
    - IPI PMID:26655834
    - TAS PMID:9230079
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - NAS PMID:26655834
  - term: GO:0035861 site of double-strand break
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
- organism: human
  gene: ARPC4
  row_index: 61
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:20458337 "we first analyzed the total proteome of highly purified B cell-derived exosomes using sensitive
    and accurate mass spectrometry (MS), and identified 539 proteins"]'
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9359840}.
    Nucleus {ECO:0000269|PubMed:29925947}.
  uniprot_function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization
    upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched
    actin networks in the cytoplasm, providing the force for cell motilit ...
  uniprot_features: *id025
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id026
- organism: human
  gene: ARPC5
  row_index: 52
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:19056867 "Here, we used LC-MS/MS to profile the proteome of human urinary exosomes."]'
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}.
    Nucleus {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:37349293}.
  uniprot_function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation
    by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks
    in the cytoplasm, providing the force for cell motility (PubMed:9230 ...
  uniprot_features: &id027 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id028
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:29925947
    - IEA GO_REF:0000044
    - IMP PMID:37349293
    - ISS GO_REF:0000024
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:9359840
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1861595
    - TAS Reactome:R-HSA-2029466
    - TAS Reactome:R-HSA-2029473
    - TAS Reactome:R-HSA-2029476
    - TAS Reactome:R-HSA-2197690
    - TAS Reactome:R-HSA-3928595
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
    - TAS Reactome:R-HSA-9666458
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005885 Arp2/3 protein complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:11741539
    - IEA GO_REF:0000120
    - IPI PMID:26655834
    - TAS PMID:9230079
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - NAS PMID:26655834
    - TAS PMID:9230079
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030863 cortical cytoskeleton
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0035861 site of double-strand break
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: ARPC5
  row_index: 53
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:20458337 "we first analyzed the total proteome of highly purified B cell-derived exosomes using sensitive
    and accurate mass spectrometry (MS), and identified 539 proteins"]'
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}.
    Nucleus {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:37349293}.
  uniprot_function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation
    by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks
    in the cytoplasm, providing the force for cell motility (PubMed:9230 ...
  uniprot_features: *id027
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id028
- organism: human
  gene: ARSL
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The study-authored NIH/NHLBI inventory for PMID19056867 explicitly identifies historical ARSE (current ARSL),
    RefSeq NP_000038, with one displayed peptide and study reference 2. This target-specific detection supports the existing
    exosome location as a contextual occurrence. It does not establish a vesicular catalytic role, topology, peptide uniqueness
    or a modern isoform assignment. The normal cache is abstract-only; the target row was read separately in the primary study
    database.
  uniprot_subcellular_location: Golgi apparatus, Golgi stack {ECO:0000269|PubMed:9497243}.
  uniprot_function: Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate (PubMed:7720070,
    PubMed:9497243). May be essential for the correct composition of cartilage and bone matrix during development (PubMed:7720070).
    Has no activity toward steroid sulfates (PubMed:7720070). {EC ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-1614362
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:9497243
  - term: GO:0005795 Golgi stack
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: ASAH1
  row_index: 49
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ASAH1 is directly identified in the independent human urinary-exosome inventory linked to PMID:19056867.
    This corroborates the same extracellular-exosome compartment and supports retention as non-core with deference to the
    original PMID:23533145 curator. The exact target inventory of PMID:23533145 remains uninspected; no claim that the two
    studies used the same preparation or established a functional exosome role is made.
  uniprot_subcellular_location: 'Lysosome {ECO:0000269|PubMed:12764132}. Secreted {ECO:0000269|PubMed:7744740}. Note=Secretion
    is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent. {ECO:0000269|PubMed:11451951}.
    [Isoform 2]: Nucleus {ECO:0000305|PubMed:22927646}. Cytoplasm {ECO:0000305|PubMed:22927646}. Note=A localization to the
    nucleus and the cytoplasm has also been reported for ASAH1, most probably for isoforms devoid of a signal peptide. {ECO:0000305|PubMed:22927646}.'
  uniprot_function: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic
    pH (PubMed:10610716, PubMed:11451951, PubMed:15655246, PubMed:26898341, PubMed:36752535, PubMed:7744740, PubMed:7852294).
    Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phos ...
  uniprot_features: &id029
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id030
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:11451951
    - IDA PMID:25645918
    - IDA PMID:7744740
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-6798745
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:12764132
    - IEA GO_REF:0000120
  - term: GO:0005769 early endosome
    qualifier: NOT|located_in
    evidence:
    - IDA PMID:12764132
  - term: GO:0005783 endoplasmic reticulum
    qualifier: NOT|located_in
    evidence:
    - IDA PMID:12764132
  - term: GO:0036021 endolysosome lumen
    qualifier: is_active_in
    evidence:
    - IC PMID:27498570
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1606602
    - TAS Reactome:R-HSA-9859104
  - term: GO:1904724 tertiary granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: ASAH1
  row_index: 50
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The study-authored NHLBI Urinary Exosome Protein Database explicitly lists ASAH1 NP_808592 (7 peptides;
    references 1 and 2) and NP_004306 (9 peptides; reference 2). Reference 2 links PMID:19056867. This directly resolves target
    identification in the human urinary-exosome study. Detection supports the location but does not establish enzymatic work
    within exosomes; retain as non-core relative to lysosomal ceramide hydrolysis. The database accession labels are not used
    to change the original gene-product or isoform fields.
  uniprot_subcellular_location: 'Lysosome {ECO:0000269|PubMed:12764132}. Secreted {ECO:0000269|PubMed:7744740}. Note=Secretion
    is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent. {ECO:0000269|PubMed:11451951}.
    [Isoform 2]: Nucleus {ECO:0000305|PubMed:22927646}. Cytoplasm {ECO:0000305|PubMed:22927646}. Note=A localization to the
    nucleus and the cytoplasm has also been reported for ASAH1, most probably for isoforms devoid of a signal peptide. {ECO:0000305|PubMed:22927646}.'
  uniprot_function: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic
    pH (PubMed:10610716, PubMed:11451951, PubMed:15655246, PubMed:26898341, PubMed:36752535, PubMed:7744740, PubMed:7852294).
    Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phos ...
  uniprot_features: *id029
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id030
- organism: human
  gene: ASL
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The study-authored NHLBI Urinary Exosome Protein Database explicitly lists ASL NP_001020117 with one peptide
    and reference 2, which links PMID:19056867. This verifies target detection in that human urinary-exosome study. It supports
    a non-core location, without demonstrating catalytic work in exosomes or contamination. The database isoform label does
    not change the original source assertion or establish peptide uniqueness for a modern ASL isoform.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step
    reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo
    L-arginine synthesis in nonhepatic tissues (PubMed:11747432, PubMed:117474 ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:282632
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-70573
    - TAS Reactome:R-HSA-9956524
- organism: human
  gene: ASS1
  row_index: 76
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: 'The study laboratory''s NIH/NHLBI urinary-exosome database explicitly lists ASS1, argininosuccinate synthetase
    1, RefSeq NP_000041, and assigns the entry to references 1 and 2; reference 2 is the original PMID:19056867 study. The
    database header specifies healthy human urinary exosomes and provides the instrument/reference mapping. This closes target-level
    detection for this source. It does not establish an intravesicular catalytic role, membrane topology or a classical secretory
    function. The displayed peptide count 20 is an aggregate database field and is not independently assigned to this one
    study. Source: https://esbl.nhlbi.nih.gov/UrinaryExosomes/ .'
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:28985504, ECO:0000305|PubMed:27287393}.
  uniprot_function: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by
    protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from
    aspartate, citrulline and ATP and together with ASL it is responsible for th ...
  uniprot_features: []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:6194510
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005741 mitochondrial outer membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:28985504
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-70577
    - TAS Reactome:R-HSA-9956517
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043204 perikaryon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0070852 cell body fiber
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: ATP5F1A
  row_index: 71
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection of ATP5F1A in extracellular exosomes is consistent with its abundance and the known presence of
    mitochondrial proteins in exosomes. This is a non-core localization.
  uniprot_subcellular_location: Mitochondrion {ECO:0000269|PubMed:30146159}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P19483};
    Peripheral membrane protein {ECO:0000250|UniProtKB:P19483}; Matrix side {ECO:0000250|UniProtKB:P19483}. Cell membrane
    {ECO:0000269|PubMed:10077593}; Peripheral membrane protein {ECO:0000269|PubMed:10077593}; Extracellular side {ECO:0000269|PubMed:10077593}.
    Note=Colocalizes with HRG on the cell surface of T-cells (PubMed:19285951). {ECO:0000269|PubMed:19285951}.
  uniprot_function: Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V)
    that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport
    complexes of the respiratory chain (Probable). ATP synthase complex cons ...
  uniprot_features: &id031 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id032
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IC PMID:12110673
    - IDA GO_REF:0000052
    - IEA GO_REF:0000120
    - NAS PMID:1830491
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - IDA PMID:19016746
    - IEA GO_REF:0000120
    - NAS PMID:26297831
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-164832
    - TAS Reactome:R-HSA-164834
    - TAS Reactome:R-HSA-164840
    - TAS Reactome:R-HSA-8949580
    - TAS Reactome:R-HSA-9838035
    - TAS Reactome:R-HSA-9838081
    - TAS Reactome:R-HSA-9838093
    - TAS Reactome:R-HSA-9838289
    - TAS Reactome:R-HSA-9839105
    - TAS Reactome:R-HSA-9839149
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:10077593
    - IEA GO_REF:0000044
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:21106936
    - IEA GO_REF:0000107
  - term: GO:0016469 proton-transporting two-sector ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045259 proton-transporting ATP synthase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:12110673
    - IDA PMID:21106936
    - IDA PMID:37244256
    - IEA GO_REF:0000120
  - term: GO:1902495 transmembrane transporter complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
- organism: human
  gene: ATP5F1A
  row_index: 75
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in urinary exosomes is consistent with the abundance of ATP5F1A and the known presence of mitochondrial
    proteins in exosomal fractions. Non-core localization.
  uniprot_subcellular_location: Mitochondrion {ECO:0000269|PubMed:30146159}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P19483};
    Peripheral membrane protein {ECO:0000250|UniProtKB:P19483}; Matrix side {ECO:0000250|UniProtKB:P19483}. Cell membrane
    {ECO:0000269|PubMed:10077593}; Peripheral membrane protein {ECO:0000269|PubMed:10077593}; Extracellular side {ECO:0000269|PubMed:10077593}.
    Note=Colocalizes with HRG on the cell surface of T-cells (PubMed:19285951). {ECO:0000269|PubMed:19285951}.
  uniprot_function: Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V)
    that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport
    complexes of the respiratory chain (Probable). ATP synthase complex cons ...
  uniprot_features: *id031
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id032
- organism: human
  gene: ATP5F1B
  row_index: 68
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection of ATP5F1B in extracellular exosomes is consistent with the known presence of mitochondrial proteins
    in exosomes. This is a non-core localization. ATP5F1B is one of the most abundant mitochondrial proteins, and abundant
    proteins are commonly detected in exosome proteomics.
  uniprot_subcellular_location: Mitochondrion inner membrane {ECO:0000269|PubMed:25168243}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00829};
    Matrix side {ECO:0000250|UniProtKB:P00829, ECO:0000269|PubMed:25168243}.
  uniprot_function: Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex
    V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron
    transport complexes of the respiratory chain (Probable) (PubMed:37244256) ...
  uniprot_features: &id033 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id034
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IC PMID:12110673
    - IDA GO_REF:0000052
    - IDA PMID:25168243
    - IDA PMID:2870059
    - IEA GO_REF:0000107
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:26297831
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - NAS PMID:2687158
    - TAS Reactome:R-HSA-1592247
    - TAS Reactome:R-HSA-164832
    - TAS Reactome:R-HSA-164834
    - TAS Reactome:R-HSA-164840
    - TAS Reactome:R-HSA-8949580
    - TAS Reactome:R-HSA-9838035
    - TAS Reactome:R-HSA-9838081
    - TAS Reactome:R-HSA-9838093
    - TAS Reactome:R-HSA-9838289
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:10077593
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:17510399
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:21106936
  - term: GO:0016469 proton-transporting two-sector ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0031966 mitochondrial membrane
    qualifier: located_in
    evidence:
    - IDA PMID:8006588
  - term: GO:0042645 mitochondrial nucleoid
    qualifier: located_in
    evidence:
    - IDA PMID:18063578
  - term: GO:0045259 proton-transporting ATP synthase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:12110673
    - IDA PMID:21106936
    - IDA PMID:37244256
    - IEA GO_REF:0000120
    - NAS PMID:2870059
  - term: GO:1902495 transmembrane transporter complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
- organism: human
  gene: ATP5F1B
  row_index: 72
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in parotid gland exosomes. Non-core localization, likely reflecting abundance of the protein.
  uniprot_subcellular_location: Mitochondrion inner membrane {ECO:0000269|PubMed:25168243}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00829};
    Matrix side {ECO:0000250|UniProtKB:P00829, ECO:0000269|PubMed:25168243}.
  uniprot_function: Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex
    V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron
    transport complexes of the respiratory chain (Probable) (PubMed:37244256) ...
  uniprot_features: *id033
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id034
- organism: human
  gene: ATP5F1B
  row_index: 73
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. Detection in urinary exosomes likely reflects protein abundance.
  uniprot_subcellular_location: Mitochondrion inner membrane {ECO:0000269|PubMed:25168243}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00829};
    Matrix side {ECO:0000250|UniProtKB:P00829, ECO:0000269|PubMed:25168243}.
  uniprot_function: Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex
    V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron
    transport complexes of the respiratory chain (Probable) (PubMed:37244256) ...
  uniprot_features: *id033
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id034
- organism: human
  gene: ATP5F1B
  row_index: 74
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. Detection in B-cell exosomes.
  uniprot_subcellular_location: Mitochondrion inner membrane {ECO:0000269|PubMed:25168243}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00829};
    Matrix side {ECO:0000250|UniProtKB:P00829, ECO:0000269|PubMed:25168243}.
  uniprot_function: Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex
    V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron
    transport complexes of the respiratory chain (Probable) (PubMed:37244256) ...
  uniprot_features: *id033
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id034
- organism: human
  gene: ATP6AP2
  row_index: 54
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The original NIH/NHLBI study inventory explicitly lists human ATP6AP2, NP_005756, one peptide, reference
    2 linked to 19056867. Retain contextual exosome occurrence, not vesicular activity or topology.
  uniprot_subcellular_location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29127204}; Single-pass type I membrane
    protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:29127204}; Single- pass type I membrane protein {ECO:0000305}.
    Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}.
    Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}.
    Cell projection, axon {ECO:0000250|UniProtKB:Q9CYN9}. Endosome membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type
    I membrane pr ...
  uniprot_function: Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the
    assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system
    (PubMed:12045255, PubMed:29127204, PubMed:30374053, PubMed:32276428). May me ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32001091
  - term: GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:29127204
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - EXP PMID:29127204
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - NAS PMID:32001091
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - IDA PMID:29127204
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32001091
    - TAS Reactome:R-HSA-2022403
    - TAS Reactome:R-HSA-2065357
    - TAS Reactome:R-HSA-6798747
    - TAS Reactome:R-HSA-6800426
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:12045255
    - IDA PMID:15746149
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - NAS PMID:32001091
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:33065002
    - IEA GO_REF:0000002
  - term: GO:0016471 vacuolar proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IMP PMID:29127204
    - IMP PMID:30985297
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030665 clathrin-coated vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032591 dendritic spine membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0033176 proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - NAS PMID:33065002
  - term: GO:0070821 tertiary granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798747
  - term: GO:0098588 bounding membrane of organelle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0101003 ficolin-1-rich granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800426
- organism: human
  gene: ATP6V0A4
  row_index: 25
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Parotid exosome detection is a high-throughput extracellular-vesicle context and should not drive core functional
    interpretation.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:10973252}; Multi-pass membrane protein {ECO:0000255}.
    Basolateral cell membrane {ECO:0000250|UniProtKB:Q920R6}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to
    the apical surface of alpha- intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:10973252).
    Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron
    (By similarity). {ECO:0000250|UniProtKB:Q920R6, ECO:0000269|PubMed:10973252}.
  uniprot_function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase
    is responsible for acidifying and maintaining the pH of intracellular  ...
  uniprot_features: &id035
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id036
  - term: GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17360703
    - NAS PMID:32001091
  - term: GO:0005903 brush border
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5252133
    - TAS Reactome:R-HSA-74723
    - TAS Reactome:R-HSA-917841
  - term: GO:0016323 basolateral plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:10973252
    - IDA PMID:12649290
    - IDA PMID:15800125
    - IEA GO_REF:0000120
  - term: GO:0016471 vacuolar proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:10973252
    - IEA GO_REF:0000107
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1222516
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031526 brush border membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14638902
  - term: GO:0033176 proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - NAS PMID:33065002
  - term: GO:0033179 proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0045177 apical part of cell
    qualifier: located_in
    evidence:
    - IDA PMID:14638902
    - IDA PMID:14675051
    - IEA GO_REF:0000120
- organism: human
  gene: ATP6V0A4
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Urinary exosome detection is relevant to renal epithelial membranes but remains a high-throughput vesicle-location
    observation, not a core ATP6V0A4 function.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:10973252}; Multi-pass membrane protein {ECO:0000255}.
    Basolateral cell membrane {ECO:0000250|UniProtKB:Q920R6}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to
    the apical surface of alpha- intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:10973252).
    Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron
    (By similarity). {ECO:0000250|UniProtKB:Q920R6, ECO:0000269|PubMed:10973252}.
  uniprot_function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase
    is responsible for acidifying and maintaining the pH of intracellular  ...
  uniprot_features: *id035
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id036
- organism: human
  gene: ATP6V0C
  row_index: 56
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. V-ATPase subunits have been found in exosomes, consistent with their membrane
    localization and vesicular trafficking. However, this is not a primary functional localization.
  uniprot_subcellular_location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass
    membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P63081};
    Multi-pass membrane protein {ECO:0000255}.
  uniprot_function: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit
    enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates
    protons (PubMed:33065002, PubMed:36074901). V-ATPase is responsible for a ...
  uniprot_features:
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32001091
  - term: GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32001091
    - TAS Reactome:R-HSA-9639286
    - TAS Reactome:R-HSA-9640167
    - TAS Reactome:R-HSA-9640168
    - TAS Reactome:R-HSA-9640175
    - TAS Reactome:R-HSA-9640195
    - TAS Reactome:R-HSA-9645598
    - TAS Reactome:R-HSA-9645608
    - TAS Reactome:R-HSA-9646468
    - TAS Reactome:R-HSA-9858913
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32001091
    - TAS Reactome:R-HSA-6798739
    - TAS Reactome:R-HSA-6798747
    - TAS Reactome:R-HSA-6800426
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32001091
    - TAS Reactome:R-HSA-5252133
    - TAS Reactome:R-HSA-74723
    - TAS Reactome:R-HSA-917841
  - term: GO:0016020 membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:33065002
    - TAS PMID:1709739
  - term: GO:0030665 clathrin-coated vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1222516
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000043
  - term: GO:0033176 proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
    - NAS PMID:33065002
  - term: GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0033179 proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0035577 azurophil granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
  - term: GO:0070821 tertiary granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798747
  - term: GO:0098588 bounding membrane of organelle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0101003 ficolin-1-rich granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800426
- organism: human
  gene: ATP6V0D1
  row_index: 43
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ATP6V0D1 can be detected in exosome proteomics datasets, consistent with endomembrane origin and vesicle
    biology. These HDA rows should not drive functional interpretation.
  uniprot_subcellular_location: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891};
    Cytoplasmic side {ECO:0000305|PubMed:21844891}. Lysosome membrane {ECO:0000305|PubMed:30374053}; Peripheral membrane protein
    {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P61420}; Peripheral membrane
    protein {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1}.
  uniprot_function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053,
    PubMed:33065002). V-ATPase is responsible for acidifying and  ...
  uniprot_features: &id037 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id038
  - term: GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005765 lysosomal membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:22053050
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-9639286
    - TAS Reactome:R-HSA-9640167
    - TAS Reactome:R-HSA-9640168
    - TAS Reactome:R-HSA-9640175
    - TAS Reactome:R-HSA-9640195
    - TAS Reactome:R-HSA-9645598
    - TAS Reactome:R-HSA-9645608
    - TAS Reactome:R-HSA-9646468
    - TAS Reactome:R-HSA-9858932
  - term: GO:0005769 early endosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005813 centrosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:21844891
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1791184
    - TAS Reactome:R-HSA-5252133
    - TAS Reactome:R-HSA-74723
    - TAS Reactome:R-HSA-917841
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:18752060
    - IEA GO_REF:0000044
  - term: GO:0016471 vacuolar proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18752060
    - IEA GO_REF:0000117
    - NAS PMID:11118322
  - term: GO:0030665 clathrin-coated vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-1222516
  - term: GO:0033176 proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0033179 proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0033181 plasma membrane proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0046611 lysosomal proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IDA PMID:22053050
  - term: GO:0098793 presynapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
- organism: human
  gene: ATP6V0D1
  row_index: 45
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ATP6V0D1 can be detected in exosome proteomics datasets, consistent with endomembrane origin and vesicle
    biology. These HDA rows should not drive functional interpretation.
  uniprot_subcellular_location: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891};
    Cytoplasmic side {ECO:0000305|PubMed:21844891}. Lysosome membrane {ECO:0000305|PubMed:30374053}; Peripheral membrane protein
    {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P61420}; Peripheral membrane
    protein {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1}.
  uniprot_function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053,
    PubMed:33065002). V-ATPase is responsible for acidifying and  ...
  uniprot_features: *id037
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id038
- organism: human
  gene: ATP6V0D1
  row_index: 46
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ATP6V0D1 can be detected in exosome proteomics datasets, consistent with endomembrane origin and vesicle
    biology. These HDA rows should not drive functional interpretation.
  uniprot_subcellular_location: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891};
    Cytoplasmic side {ECO:0000305|PubMed:21844891}. Lysosome membrane {ECO:0000305|PubMed:30374053}; Peripheral membrane protein
    {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P61420}; Peripheral membrane
    protein {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1}.
  uniprot_function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053,
    PubMed:33065002). V-ATPase is responsible for acidifying and  ...
  uniprot_features: *id037
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id038
- organism: human
  gene: ATP6V0D2
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics identification in exosomes. While technically valid, this does not represent
    a functional localization and may be incidental. Retain as non-core.
  uniprot_subcellular_location: ''
  uniprot_function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible
    for acidifying and maintaining the pH of intracellular compartments and ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9639286
    - TAS Reactome:R-HSA-9640167
    - TAS Reactome:R-HSA-9640168
    - TAS Reactome:R-HSA-9640175
    - TAS Reactome:R-HSA-9640195
    - TAS Reactome:R-HSA-9645598
    - TAS Reactome:R-HSA-9645608
    - TAS Reactome:R-HSA-9646468
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005769 early endosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5252133
    - TAS Reactome:R-HSA-74723
    - TAS Reactome:R-HSA-917841
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:18752060
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15800125
    - IEA GO_REF:0000107
  - term: GO:0016471 vacuolar proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18752060
    - IEA GO_REF:0000117
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-1222516
  - term: GO:0033179 proton-transporting V-type ATPase, V0 domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0033181 plasma membrane proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
- organism: human
  gene: ATP6V1G1
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular exosome identification from urinary proteomics (PMID:19056867) is likely a contaminant in
    the exosome-enriched fraction rather than genuine exosomal loading. Not a core localization for this cytosolic V1 peripheral
    stalk subunit.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:29993276}.
  uniprot_function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral
    complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002).
    V-ATPase is responsible for acidifying and maintaining the p ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:33065002
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-1222516
    - TAS Reactome:R-HSA-5252133
    - TAS Reactome:R-HSA-74723
    - TAS Reactome:R-HSA-917841
    - TAS Reactome:R-HSA-9639286
    - TAS Reactome:R-HSA-9640167
    - TAS Reactome:R-HSA-9640168
    - TAS Reactome:R-HSA-9640175
    - TAS Reactome:R-HSA-9640195
    - TAS Reactome:R-HSA-9645598
    - TAS Reactome:R-HSA-9645608
    - TAS Reactome:R-HSA-9646468
    - TAS Reactome:R-HSA-9858924
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17360703
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:29993276
    - IEA GO_REF:0000044
  - term: GO:0016471 vacuolar proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0033176 proton-transporting V-type ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0033180 proton-transporting V-type ATPase, V1 domain
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098850 extrinsic component of synaptic vesicle membrane
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: ATRN
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:19056867 "Here, we used LC-MS/MS to profile the proteome of human urinary exosomes."]'
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000269|PubMed:7539799}; Single-pass type I membrane protein
    {ECO:0000269|PubMed:7539799}. [Isoform 2]: Secreted {ECO:0000269|PubMed:7539799, ECO:0000269|PubMed:9736737}. [Isoform
    3]: Secreted {ECO:0000269|PubMed:7539799}.'
  uniprot_function: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic
    activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color.
    Low-affinity receptor for agouti (By similarity). Has a critical role i ...
  uniprot_features: &id039
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id040
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:7539799
    - IDA PMID:17261078
    - IEA GO_REF:0000044
    - TAS PMID:9736737
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:7539799
    - IEA GO_REF:0000044
    - NAS PMID:9736737
    - TAS PMID:10086356
- organism: human
  gene: ATRN
  row_index: 12
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[PMID:23533145 "Using expressed prostatic secretions in urine (EPS-urine), exosome preparations were characterized
    by a shotgun proteomics procedure."]'
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000269|PubMed:7539799}; Single-pass type I membrane protein
    {ECO:0000269|PubMed:7539799}. [Isoform 2]: Secreted {ECO:0000269|PubMed:7539799, ECO:0000269|PubMed:9736737}. [Isoform
    3]: Secreted {ECO:0000269|PubMed:7539799}.'
  uniprot_function: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic
    activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color.
    Low-affinity receptor for agouti (By similarity). Has a critical role i ...
  uniprot_features: *id039
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id040
- organism: human
  gene: AZGP1
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[file:human/AZGP1/AZGP1-uniprot.txt "CC -!- SUBCELLULAR LOCATION: Secreted."] [file:human/AZGP1/AZGP1-uniprot.txt
    "CC -!- TISSUE SPECIFICITY: Blood plasma, seminal plasma, urine, saliva, sweat,"]'
  uniprot_subcellular_location: Secreted.
  uniprot_function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced
    cancers. May bind polyunsaturated fatty acids.
  uniprot_features: &id041
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id042
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:24248522
    - IEA GO_REF:0000044
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-5252072
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
- organism: human
  gene: AZGP1
  row_index: 27
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: '[file:human/AZGP1/AZGP1-uniprot.txt "CC -!- SUBCELLULAR LOCATION: Secreted."] [file:human/AZGP1/AZGP1-uniprot.txt
    "CC -!- TISSUE SPECIFICITY: Blood plasma, seminal plasma, urine, saliva, sweat,"]'
  uniprot_subcellular_location: Secreted.
  uniprot_function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced
    cancers. May bind polyunsaturated fatty acids.
  uniprot_features: *id041
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id042
- organism: human
  gene: B4GALT1
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: 'Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:29133956}; Single-pass type II
    membrane protein. Note=Colocalizes with MGAT3 and ST6GAL1 in the Golgi stacks of cisternaee, including the cis-part of
    the Golgi stacks. {ECO:0000269|PubMed:29133956}. [Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903,
    ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:1714903}; Single-pass
    type II membrane protein. Cell surface {ECO:0000269|PubMed:1714903}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}.
    Note=Fo ...'
  uniprot_function: Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose
    in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type
    N-linked glycans (PubMed:16157350, PubMed:27872474, PubMed:2 ...
  uniprot_features: &id043
  - TRANSMEM
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id044
  - term: GO:0000138 Golgi trans cisterna
    qualifier: located_in
    evidence:
    - IDA PMID:6121819
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-2025723
    - TAS Reactome:R-HSA-2046265
    - TAS Reactome:R-HSA-2046298
    - TAS Reactome:R-HSA-3656230
    - TAS Reactome:R-HSA-4793956
    - TAS Reactome:R-HSA-5653878
    - TAS Reactome:R-HSA-5653886
    - TAS Reactome:R-HSA-9035949
    - TAS Reactome:R-HSA-9035950
    - TAS Reactome:R-HSA-975919
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:2120039
  - term: GO:0005794 Golgi apparatus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:10900002
    - IDA PMID:7744867
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:1714903
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1297338
    - TAS Reactome:R-HSA-6798739
    - TAS Reactome:R-HSA-6798743
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:3917437
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - EXP PMID:1714903
    - IEA GO_REF:0000120
  - term: GO:0016323 basolateral plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:3917437
  - term: GO:0030057 desmosome
    qualifier: located_in
    evidence:
    - IDA PMID:3917437
  - term: GO:0030175 filopodium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030667 secretory granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0031526 brush border membrane
    qualifier: located_in
    evidence:
    - IDA PMID:3917437
  - term: GO:0032580 Golgi cisterna membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0035577 azurophil granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
- organism: human
  gene: B4GALT1
  row_index: 47
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: 'Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:29133956}; Single-pass type II
    membrane protein. Note=Colocalizes with MGAT3 and ST6GAL1 in the Golgi stacks of cisternaee, including the cis-part of
    the Golgi stacks. {ECO:0000269|PubMed:29133956}. [Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903,
    ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:1714903}; Single-pass
    type II membrane protein. Cell surface {ECO:0000269|PubMed:1714903}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}.
    Note=Fo ...'
  uniprot_function: Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose
    in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type
    N-linked glycans (PubMed:16157350, PubMed:27872474, PubMed:2 ...
  uniprot_features: *id043
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id044
- organism: human
  gene: B4GALT1
  row_index: 48
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: 'Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:29133956}; Single-pass type II
    membrane protein. Note=Colocalizes with MGAT3 and ST6GAL1 in the Golgi stacks of cisternaee, including the cis-part of
    the Golgi stacks. {ECO:0000269|PubMed:29133956}. [Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903,
    ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:1714903}; Single-pass
    type II membrane protein. Cell surface {ECO:0000269|PubMed:1714903}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}.
    Note=Fo ...'
  uniprot_function: Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose
    in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type
    N-linked glycans (PubMed:16157350, PubMed:27872474, PubMed:2 ...
  uniprot_features: *id043
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id044
- organism: human
  gene: BAIAP2
  row_index: 77
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal presence may reflect its membrane association but is not a core localization.
  uniprot_subcellular_location: Cytoplasm. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:38149472}. Cell projection,
    filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of
    specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are
    formed upon infection by bacteria at bacterial attachment sites.
  uniprot_function: Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary
    for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation
    of the actin cytoskeleton by WASF family members and the Arp2/3 compl ...
  uniprot_features: &id045 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id046
  - term: GO:0001726 ruffle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS PMID:10343108
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:19366662
    - TAS Reactome:R-HSA-2029465
    - TAS Reactome:R-HSA-2029466
    - TAS Reactome:R-HSA-2029469
    - TAS Reactome:R-HSA-2130194
    - TAS Reactome:R-HSA-2197690
    - TAS Reactome:R-HSA-9013145
    - TAS Reactome:R-HSA-9013157
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005874 microtubule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000117
    - TAS PMID:10343108
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:38149472
  - term: GO:0014069 postsynaptic density
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0015629 actin cytoskeleton
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:19366662
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030141 secretory granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030175 filopodium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043197 dendritic spine
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043198 dendritic shaft
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0044306 neuron projection terminus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0060076 excitatory synapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0061845 neuron projection branch point
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0061846 dendritic spine cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0097060 synaptic membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098793 presynapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098794 postsynapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099092 postsynaptic density, intracellular component
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099523 presynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099524 postsynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: BAIAP2
  row_index: 78
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal presence is not a core localization.
  uniprot_subcellular_location: Cytoplasm. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:38149472}. Cell projection,
    filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of
    specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are
    formed upon infection by bacteria at bacterial attachment sites.
  uniprot_function: Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary
    for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation
    of the actin cytoskeleton by WASF family members and the Arp2/3 compl ...
  uniprot_features: *id045
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id046
- organism: human
  gene: BAIAP2L1
  row_index: 24
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal presence is likely incidental to IRTKS's cytoplasmic/membrane functions rather than a primary localization.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19366662}. Note=Recruited to actin pedestals that
    are formed upon infection by bacteria at bacterial attachment sites.
  uniprot_function: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role
    in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662,
    ECO:0000269|PubMed:22921828}.
  uniprot_features: &id047 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id048
  - term: GO:0005654 nucleoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:19366662
    - TAS Reactome:R-HSA-9693125
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0015629 actin cytoskeleton
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:19366662
- organism: human
  gene: BAIAP2L1
  row_index: 25
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal detection likely reflects packaging of cytoplasmic proteins into exosomes rather than a specific
    exosome-associated function.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19366662}. Note=Recruited to actin pedestals that
    are formed upon infection by bacteria at bacterial attachment sites.
  uniprot_function: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role
    in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662,
    ECO:0000269|PubMed:22921828}.
  uniprot_features: *id047
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id048
- organism: human
  gene: BLVRA
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The complete abstract describes human urinary-exosome proteomics, but the BLVRA-specific peptide/table entry
    is not in the normal abstract-only cache and was not independently verified. Retain the HDA detection as a curator-supported
    non-core association; do not assert that BLVRA is common vesicle cargo, a secretion factor, or incapable of extracellular
    function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.
  uniprot_function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant
    oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce
    bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NAD ...
  uniprot_features: &id049 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id050
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IDA PMID:7929092
    - IDA PMID:8424666
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-189384
- organism: human
  gene: BLVRA
  row_index: 29
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The abstract reports exosome proteomics but does not expose the BLVRA-specific table entry. Keep the curated
    HDA association with that limitation; detection does not itself establish an extracellular catalytic role or a role in
    exosome biogenesis.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.
  uniprot_function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant
    oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce
    bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NAD ...
  uniprot_features: *id049
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id050
- organism: human
  gene: C5orf46
  row_index: 15
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: 'The protein was catalogued in the exosome fraction of human parotid saliva by shotgun proteomics, and the
    detection is coherent rather than incidental: HGNC''s alias name for the gene is skin and saliva secreted protein 1, the
    Human Protein Atlas calls expression group-enriched in blood vessel, salivary gland and skin, and the only functional
    paper reports the same salivary-gland and skin distribution. Verified as a descendant of GO:0005576, so this row and the
    extracellular-region row are consistent rather than competing, with this one strictly more specific. It is retained for
    that reason. Non-core rather than core, on two grounds. The first is what the evidence is: a single HDA detection in one
    large-scale dataset, which the HDA code already encodes as such, and an exosome preparation from a secretory fluid co-purifies
    abundant soluble secreted proteins routinely. The second is decisive, and it is about what a core location asserts. Every
    measurement of what this peptide does was made on free peptide added to a bacterial culture or injected into an animal,
    and the paper''s own SUMO-fusion control - activity abolished by an N-terminal tag and restored on cleavage - argues that
    the functional species is free soluble peptide rather than peptide packaged in a vesicle. Nothing shows the peptide acting
    in or on an exosome lumen. Listing it among core locations would therefore assert a compartment of action that no experiment
    supports, so the core location is GO:0005576 alone. The wider practice agrees: across the merged human reviews GO:0070062
    is kept non-core or marked over-annotated about eight times for every acceptance, and it appears in core_functions.locations
    in only two genes, both with genuine exosome biology. One limitation stated plainly: the cached copy of this paper does
    not include the protein catalogue in which C5orf46 appears, so no sentence of it is quoted about this gene and the row
    is assessed on its provenance. That provenance was checked, and the check came back clean rather than damning. Fully paginated,
    the reference carries 396 annotations over 396 distinct entities, all to GO:0070062, all HDA, all assigned by UniProt
    - one entity, one annotation, one localisation term - and no functional or phenotype term appears anywhere in it. That
    is a proteomic inventory, not the pattern in which one experiment''s phenotype is projected across a set of proteins.'
  uniprot_subcellular_location: Secreted {ECO:0000305}.
  uniprot_function: ''
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: CA2
  row_index: 86
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The original authors' NHLBI Urinary Exosome Protein Database explicitly lists CA2, RefSeq NP_000058, nine
    peptides and references 1/2, with reference 2 the original PMID19056867 study. This target-specific data record supports
    the HDA location despite the abstract not naming CAII. It establishes detection in the recovered vesicle fraction, not
    a dedicated secretion mechanism or an extracellular catalytic core. The complete supplemental spectra were not independently
    reanalyzed.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized
    with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the
    cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000269|PubMed:15990874}.
  uniprot_function: Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900,
    PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203,
    PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16 ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:114507
    - IDA PMID:15990874
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-1475022
    - TAS Reactome:R-HSA-1475026
    - TAS Reactome:R-HSA-1475435
    - TAS Reactome:R-HSA-1475436
    - TAS Reactome:R-HSA-9707419
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15990874
    - IEA GO_REF:0000044
  - term: GO:0043209 myelin sheath
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045177 apical part of cell
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045177 apical part of cell
    qualifier: located_in
    evidence:
    - IDA PMID:14675051
- organism: human
  gene: CALM1
  row_index: 89
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The study reports proteomic analysis of exosome-like vesicles from human airway epithelia, consistent with
    the curated vesicle association. The individual calmodulin entry and vesicle-loading mechanism were not inspected; no
    active secretion or dedicated extracellular function is inferred.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle
    pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
    Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P0DP26}. Note=Distributed throughout the cell during interphase,
    but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
  uniprot_function: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number
    of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752,
    PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35 ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000922 spindle pole
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000120
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-482772
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-111915
    - TAS Reactome:R-HSA-2730867
    - TAS Reactome:R-HSA-442749
    - TAS Reactome:R-HSA-4551465
    - TAS Reactome:R-NUL-9618916
    - TAS Reactome:R-NUL-9619177
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:27165696
    - TAS PMID:10899953
  - term: GO:0005813 centrosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000120
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-111966
    - TAS Reactome:R-HSA-1497784
    - TAS Reactome:R-HSA-1497796
    - TAS Reactome:R-HSA-1497810
    - TAS Reactome:R-HSA-1855153
    - TAS Reactome:R-HSA-202110
    - TAS Reactome:R-HSA-202111
    - TAS Reactome:R-HSA-202127
    - TAS Reactome:R-HSA-202129
    - TAS Reactome:R-HSA-2025890
    - TAS Reactome:R-HSA-2730849
    - TAS Reactome:R-HSA-2730867
    - TAS Reactome:R-HSA-2730872
    - TAS Reactome:R-HSA-3229181
    - TAS Reactome:R-HSA-4332358
    - TAS Reactome:R-HSA-4332359
    - TAS Reactome:R-HSA-4332363
    - TAS Reactome:R-HSA-445797
    - TAS Reactome:R-HSA-445813
    - TAS Reactome:R-HSA-451283
    - TAS Reactome:R-HSA-451311
    - TAS Reactome:R-HSA-4551451
    - TAS Reactome:R-HSA-4551465
    - TAS Reactome:R-HSA-482772
    - TAS Reactome:R-HSA-5672965
    - TAS Reactome:R-HSA-6786205
    - TAS Reactome:R-HSA-71541
    - TAS Reactome:R-HSA-71588
    - TAS Reactome:R-HSA-9618785
    - TAS Reactome:R-HSA-9619355
    - TAS Reactome:R-HSA-9619376
    - TAS Reactome:R-HSA-9653585
    - TAS Reactome:R-HSA-9654521
    - TAS Reactome:R-HSA-9654523
    - TAS Reactome:R-HSA-9654525
    - TAS Reactome:R-HSA-9654533
    - TAS Reactome:R-HSA-9865670
    - TAS Reactome:R-NUL-9617449
    - TAS Reactome:R-NUL-9619243
    - TAS Reactome:R-NUL-9619396
    - TAS Reactome:R-NUL-9619413
  - term: GO:0005876 spindle microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000117
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS PMID:10899953
    - TAS Reactome:R-HSA-202110
    - TAS Reactome:R-HSA-202111
    - TAS Reactome:R-HSA-202129
    - TAS Reactome:R-HSA-202137
    - TAS Reactome:R-HSA-202144
    - TAS Reactome:R-HSA-5626549
  - term: GO:0008076 voltage-gated potassium channel complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030017 sarcomere
    qualifier: located_in
    evidence:
    - IDA PMID:20226167
    - IEA GO_REF:0000117
  - term: GO:0031514 motile cilium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:19855925
  - term: GO:0034704 calcium channel complex
    qualifier: part_of
    evidence:
    - IDA PMID:23040497
    - IEA GO_REF:0000117
  - term: GO:0043209 myelin sheath
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043209 myelin sheath
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0044305 calyx of Held
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0097225 sperm midpiece
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099523 presynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1902494 catalytic complex
    qualifier: part_of
    evidence:
    - IDA PMID:11807546
- organism: human
  gene: CALM2
  row_index: 66
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The source describes proteomic characterization of vesicles from human airway epithelium. Retain the curated
    HDA association with explicit deference for the uninspected target table; no vesicle-lumen topology or CALM2-specific
    peptide assignment is claimed.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle
    pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
    Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle
    poles and the spindle microtubules.
  uniprot_function: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number
    of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696).
    Calcium-binding is required for the activation of calmoduli ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000922 spindle pole
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000120
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:27165696
    - TAS PMID:10899953
  - term: GO:0005813 centrosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000120
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9956602
    - TAS Reactome:R-HSA-9956624
    - TAS Reactome:R-HSA-9956667
  - term: GO:0005876 spindle microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000117
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS PMID:10899953
  - term: GO:0008076 voltage-gated potassium channel complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0030017 sarcomere
    qualifier: located_in
    evidence:
    - IDA PMID:20226167
    - IEA GO_REF:0000117
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:19855925
  - term: GO:0034704 calcium channel complex
    qualifier: part_of
    evidence:
    - IDA PMID:23040497
    - IEA GO_REF:0000117
  - term: GO:0043209 myelin sheath
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043209 myelin sheath
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0044305 calyx of Held
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0097225 sperm midpiece
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099523 presynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1902494 catalytic complex
    qualifier: part_of
    evidence:
    - IDA PMID:11807546
- organism: human
  gene: CALM3
  row_index: 89
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The study reports proteomic analysis of exosome-like vesicles from human airway epithelia, consistent with
    the curated vesicle association. The individual calmodulin entry and vesicle-loading mechanism were not inspected; no
    active secretion or dedicated extracellular function is inferred.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle
    pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
    Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle
    poles and the spindle microtubules.
  uniprot_function: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number
    of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding
    is required for the activation of calmodulin (PubMed:1676042 ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000785 chromatin
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0000922 spindle pole
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000120
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:10899953
  - term: GO:0005813 centrosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000120
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9956602
    - TAS Reactome:R-HSA-9956624
    - TAS Reactome:R-HSA-9956667
  - term: GO:0005876 spindle microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:16760425
    - IEA GO_REF:0000117
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS PMID:10899953
  - term: GO:0008076 voltage-gated potassium channel complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030017 sarcomere
    qualifier: located_in
    evidence:
    - IDA PMID:20226167
    - IEA GO_REF:0000117
  - term: GO:0030426 growth cone
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: colocalizes_with
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0031966 mitochondrial membrane
    qualifier: colocalizes_with
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:19855925
  - term: GO:0034704 calcium channel complex
    qualifier: part_of
    evidence:
    - IDA PMID:23040497
    - IEA GO_REF:0000117
  - term: GO:0043209 myelin sheath
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043209 myelin sheath
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0044305 calyx of Held
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0097225 sperm midpiece
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098685 Schaffer collateral - CA1 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0099523 presynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0099524 postsynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:1902494 catalytic complex
    qualifier: part_of
    evidence:
    - IDA PMID:11807546
- organism: human
  gene: CALR
  row_index: 115
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput exosome detection; secondary to ER function.
  uniprot_subcellular_location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:10358038, ECO:0000269|PubMed:11149926}. Cytoplasm,
    cytosol {ECO:0000269|PubMed:11149926}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Cell surface
    {ECO:0000269|PubMed:10358038}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Cytoplasmic vesicle, secretory
    vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3H7}. Cytolytic granule {ECO:0000269|PubMed:8418194}. Note=Also found
    in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). During oocyte maturation and after parthenogenetic
    activat ...
  uniprot_function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic
    reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated
    glycoproteins that are synthesized in the ER (PubMed:7876246). Int ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0001669 acrosomal vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - IMP PMID:22377355
    - TAS Reactome:R-HSA-2247514
    - TAS Reactome:R-HSA-2507854
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:8107809
  - term: GO:0005635 nuclear envelope
    qualifier: located_in
    evidence:
    - IDA PMID:21590275
    - IEA GO_REF:0000107
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:1911778
    - IEA GO_REF:0000117
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IDA PMID:35948544
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:23011799
    - IDA PMID:23395171
    - IDA PMID:30188326
    - IEA GO_REF:0000120
    - TAS PMID:16130169
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - EXP PMID:10358038
    - IDA PMID:11149926
    - IDA PMID:21590275
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1791082
    - TAS Reactome:R-HSA-535717
    - TAS Reactome:R-HSA-548890
    - TAS Reactome:R-HSA-901047
  - term: GO:0005790 smooth endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:11149926
    - IEA GO_REF:0000044
  - term: GO:0005840 ribosome
    qualifier: located_in
    evidence:
    - IDA PMID:14726956
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - EXP PMID:10358038
    - IEA GO_REF:0000120
    - TAS PMID:15474971
  - term: GO:0012505 endomembrane system
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:22572157
  - term: GO:0016529 sarcoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8951595
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0033018 sarcoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8863858
    - TAS Reactome:R-HSA-8863914
    - TAS Reactome:R-HSA-8951595
  - term: GO:0042824 MHC class I peptide loading complex
    qualifier: part_of
    evidence:
    - IDA PMID:21263072
    - IDA PMID:35948544
    - IEA GO_REF:0000107
    - ISS PMID:11825569
  - term: GO:0044194 cytolytic granule
    qualifier: located_in
    evidence:
    - EXP PMID:8418194
    - IEA GO_REF:0000044
  - term: GO:0044322 endoplasmic reticulum quality control compartment
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:1911778
    - IEA GO_REF:0000107
  - term: GO:0060473 cortical granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0071682 endocytic vesicle lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2247514
    - TAS Reactome:R-HSA-2507854
  - term: GO:0098553 lumenal side of endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8863914
    - TAS Reactome:R-HSA-8951499
    - TAS Reactome:R-HSA-983142
    - TAS Reactome:R-HSA-983161
  - term: GO:0098794 postsynapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: CAPG
  row_index: 34
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is from high-throughput proteomic analysis. Many cytoplasmic proteins are detected in
    exosomes without having specific exosome-related functions.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18266911}. Cytoplasm {ECO:0000269|PubMed:17081065}.
    Melanosome {ECO:0000269|PubMed:17081065}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection,
    ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was
    observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated
    in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452}.
  uniprot_function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever
    preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic
    and/or nuclear structures through potential interactions with actin. May bin ...
  uniprot_features: &id051 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id052
  - term: GO:0001726 ruffle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:18266911
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:18938132
  - term: GO:0005730 nucleolus
    qualifier: located_in
    evidence:
    - IDA PMID:18938132
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:18266911
    - IDA PMID:18938132
    - IDA PMID:19166812
    - IDA PMID:25468996
    - IEA GO_REF:0000120
  - term: GO:0005814 centriole
    qualifier: located_in
    evidence:
    - IDA PMID:19166812
  - term: GO:0008290 F-actin capping protein complex
    qualifier: part_of
    evidence:
    - TAS PMID:1322908
  - term: GO:0015629 actin cytoskeleton
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0072686 mitotic spindle
    qualifier: located_in
    evidence:
    - IDA PMID:19166812
  - term: GO:0090543 Flemming body
    qualifier: located_in
    evidence:
    - IDA PMID:19166812
- organism: human
  gene: CAPG
  row_index: 35
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is from proteomics; not a core functional localization.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18266911}. Cytoplasm {ECO:0000269|PubMed:17081065}.
    Melanosome {ECO:0000269|PubMed:17081065}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection,
    ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was
    observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated
    in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452}.
  uniprot_function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever
    preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic
    and/or nuclear structures through potential interactions with actin. May bin ...
  uniprot_features: *id051
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id052
- organism: human
  gene: CAPG
  row_index: 36
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection from proteomics; not a core functional localization.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18266911}. Cytoplasm {ECO:0000269|PubMed:17081065}.
    Melanosome {ECO:0000269|PubMed:17081065}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection,
    ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was
    observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated
    in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452}.
  uniprot_function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever
    preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic
    and/or nuclear structures through potential interactions with actin. May bin ...
  uniprot_features: *id051
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id052
- organism: human
  gene: CD14
  row_index: 137
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in exosomes is consistent with GPI-anchored/soluble CD14 in body fluids but is
    not functionally informative.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210};
    Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}. Secreted
    {ECO:0000269|PubMed:25497142, ECO:0000269|PubMed:2779588}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus
    {ECO:0000269|PubMed:16880211}. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269|PubMed:2462937,
    ECO:0000269|PubMed:2779588, ECO:0000269|PubMed:3385210}.
  uniprot_function: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds
    to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response
    to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, Pu ...
  uniprot_features: &id053
  - LIPID
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id054
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IDA PMID:23430250
    - IDA PMID:7537731
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:25497142
    - EXP PMID:2779588
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-166041
    - TAS Reactome:R-HSA-166072
    - TAS Reactome:R-HSA-166082
    - TAS Reactome:R-HSA-166091
    - TAS Reactome:R-HSA-166119
    - TAS Reactome:R-HSA-166284
    - TAS Reactome:R-HSA-166286
    - TAS Reactome:R-HSA-166362
    - TAS Reactome:R-HSA-166363
    - TAS Reactome:R-HSA-169719
    - TAS Reactome:R-HSA-2201293
    - TAS Reactome:R-HSA-2201316
    - TAS Reactome:R-HSA-2201322
    - TAS Reactome:R-HSA-2262775
    - TAS Reactome:R-HSA-2262777
    - TAS Reactome:R-HSA-2559414
    - TAS Reactome:R-HSA-2559439
    - TAS Reactome:R-HSA-5602353
    - TAS Reactome:R-HSA-5602383
    - TAS Reactome:R-HSA-5602606
    - TAS Reactome:R-HSA-8869694
    - TAS Reactome:R-HSA-937022
    - TAS Reactome:R-HSA-937059
    - TAS Reactome:R-HSA-937079
    - TAS Reactome:R-HSA-9836227
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA PMID:16880211
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:1698311
    - EXP PMID:2462937
    - EXP PMID:3385210
    - IEA GO_REF:0000044
    - TAS PMID:9548256
    - TAS Reactome:R-HSA-166038
    - TAS Reactome:R-HSA-166041
    - TAS Reactome:R-HSA-166072
    - TAS Reactome:R-HSA-166082
    - TAS Reactome:R-HSA-166091
    - TAS Reactome:R-HSA-166119
    - TAS Reactome:R-HSA-166284
    - TAS Reactome:R-HSA-166286
    - TAS Reactome:R-HSA-166362
    - TAS Reactome:R-HSA-166363
    - TAS Reactome:R-HSA-168950
    - TAS Reactome:R-HSA-168951
    - TAS Reactome:R-HSA-2201293
    - TAS Reactome:R-HSA-2201316
    - TAS Reactome:R-HSA-2201322
    - TAS Reactome:R-HSA-2262775
    - TAS Reactome:R-HSA-2262777
    - TAS Reactome:R-HSA-2559414
    - TAS Reactome:R-HSA-2559439
    - TAS Reactome:R-HSA-2559464
    - TAS Reactome:R-HSA-2559468
    - TAS Reactome:R-HSA-5602353
    - TAS Reactome:R-HSA-5602383
    - TAS Reactome:R-HSA-5602606
    - TAS Reactome:R-HSA-6798743
    - TAS Reactome:R-HSA-937022
    - TAS Reactome:R-HSA-937059
    - TAS Reactome:R-HSA-937079
    - TAS Reactome:R-HSA-9836227
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:3385210
    - IEA GO_REF:0000107
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-166168
    - TAS Reactome:R-HSA-166175
    - TAS Reactome:R-HSA-166245
    - TAS Reactome:R-HSA-166271
    - TAS Reactome:R-HSA-168915
    - TAS Reactome:R-HSA-168921
    - TAS Reactome:R-HSA-2201293
    - TAS Reactome:R-HSA-2201338
    - TAS Reactome:R-HSA-2213017
    - TAS Reactome:R-HSA-2559568
    - TAS Reactome:R-HSA-2562541
    - TAS Reactome:R-HSA-2562564
    - TAS Reactome:R-HSA-2569057
    - TAS Reactome:R-HSA-450358
    - TAS Reactome:R-HSA-5362486
    - TAS Reactome:R-HSA-5362500
    - TAS Reactome:R-HSA-936947
    - TAS Reactome:R-HSA-936951
    - TAS Reactome:R-HSA-936952
    - TAS Reactome:R-HSA-936985
    - TAS Reactome:R-HSA-937029
    - TAS Reactome:R-HSA-937075
    - TAS Reactome:R-HSA-9823904
    - TAS Reactome:R-HSA-9823906
    - TAS Reactome:R-HSA-9823910
    - TAS Reactome:R-HSA-9823932
    - TAS Reactome:R-HSA-9823934
    - TAS Reactome:R-HSA-9823939
    - TAS Reactome:R-HSA-9824882
  - term: GO:0030667 secretory granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0045121 membrane raft
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:16880211
    - IEA GO_REF:0000120
  - term: GO:0046696 lipopolysaccharide receptor complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:11274165
- organism: human
  gene: CD14
  row_index: 138
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in exosomes is consistent with GPI-anchored/soluble CD14 in body fluids but is
    not functionally informative.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210};
    Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}. Secreted
    {ECO:0000269|PubMed:25497142, ECO:0000269|PubMed:2779588}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus
    {ECO:0000269|PubMed:16880211}. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269|PubMed:2462937,
    ECO:0000269|PubMed:2779588, ECO:0000269|PubMed:3385210}.
  uniprot_function: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds
    to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response
    to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, Pu ...
  uniprot_features: *id053
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id054
- organism: human
  gene: CD14
  row_index: 139
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in exosomes is consistent with GPI-anchored/soluble CD14 in body fluids but is
    not functionally informative.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210};
    Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}. Secreted
    {ECO:0000269|PubMed:25497142, ECO:0000269|PubMed:2779588}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus
    {ECO:0000269|PubMed:16880211}. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269|PubMed:2462937,
    ECO:0000269|PubMed:2779588, ECO:0000269|PubMed:3385210}.
  uniprot_function: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds
    to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response
    to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, Pu ...
  uniprot_features: *id053
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id054
- organism: human
  gene: CD19
  row_index: 37
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain the curated high-throughput detection without promoting exosome biogenesis to a CD19 function. The
    cached abstract describes B-cell exosome proteomics; its CD19 target table was not independently inspected.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:16672701,
    ECO:0000269|PubMed:1702139, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}; Single-pass
    type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein
    {ECO:0000250|UniProtKB:P25918}.
  uniprot_function: Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808).
    Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens
    (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling p ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:1373518
    - EXP PMID:1383329
    - EXP PMID:1702139
    - EXP PMID:2463100
    - EXP PMID:9317126
    - EXP PMID:9382888
    - IDA PMID:16672701
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-199518
    - TAS Reactome:R-HSA-2076220
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-8853252
    - TAS Reactome:R-HSA-9606887
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17213291
    - IDA PMID:20660734
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:23071339
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
- organism: human
  gene: CD48
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: GPI-anchored and raft proteins are commonly incorporated into exosomes; the detection is plausible but not
    related to CD48's function.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:1999351, ECO:0000269|PubMed:9041467}; Lipid-anchor, GPI-anchor
    {ECO:0000269|PubMed:1999351}. Membrane raft {ECO:0000269|PubMed:12007789}. Secreted {ECO:0000269|PubMed:9418191}.
  uniprot_function: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal
    immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation
    (PubMed:12007789, PubMed:19494291, PubMed:27249817, PubMed:9841922). Pa ...
  uniprot_features:
  - LIPID
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:9418191
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:1999351
    - EXP PMID:9041467
    - IEA GO_REF:0000120
    - TAS PMID:1693656
    - TAS PMID:2828034
    - TAS Reactome:R-HSA-202722
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0045121 membrane raft
    qualifier: is_active_in
    evidence:
    - IDA PMID:12007789
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:11313396
    - IEA GO_REF:0000044
- organism: human
  gene: CDH1
  row_index: 156
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: 'Extracellular exosome localization is a non-core CC reflecting passive vesicular shedding or secretion
    of E-cadherin/ectodomain fragments. Core localization is at the plasma membrane/adherens junction in epithelial cells.
    HDA evidence from large-scale proteomics. Batch 5 of #348.'
  uniprot_subcellular_location: Cell junction, adherens junction {ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:22294297,
    ECO:0000269|PubMed:27760340, ECO:0000269|PubMed:28169360}. Cell membrane {ECO:0000269|PubMed:19403558, ECO:0000269|PubMed:20859650,
    ECO:0000269|PubMed:28301459, ECO:0000269|PubMed:36309486}; Single-pass type I membrane protein. Endosome {ECO:0000269|PubMed:15689490}.
    Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15689490}. Cytoplasm {ECO:0000269|PubMed:22294297}. Cell junction,
    desmosome {ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:29999492, ECO:0000269|PubMed:33596089}. Note=Colocalizes  ...
  uniprot_function: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact
    with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous
    cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions,  ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9816273
    - TAS Reactome:R-HSA-9816275
    - TAS Reactome:R-HSA-9816278
    - TAS Reactome:R-HSA-9934330
    - TAS Reactome:R-HSA-9935209
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:34742300
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-3827958
    - TAS Reactome:R-HSA-4224014
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:22294297
    - IEA GO_REF:0000044
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9935547
    - TAS Reactome:R-HSA-9935552
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - EXP PMID:15689490
    - IEA GO_REF:0000044
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9932162
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9768614
    - TAS Reactome:R-HSA-9768618
    - TAS Reactome:R-HSA-9816273
    - TAS Reactome:R-HSA-9816276
    - TAS Reactome:R-HSA-9816277
    - TAS Reactome:R-HSA-9932162
    - TAS Reactome:R-HSA-9932344
    - TAS Reactome:R-HSA-9932352
    - TAS Reactome:R-HSA-9932913
    - TAS Reactome:R-HSA-9932988
    - TAS Reactome:R-HSA-9933194
    - TAS Reactome:R-HSA-9933380
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
  - term: GO:0005796 Golgi lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9816275
  - term: GO:0005802 trans-Golgi network
    qualifier: located_in
    evidence:
    - IMP PMID:17620337
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:19403558
    - IDA GO_REF:0000052
    - IDA PMID:20859650
    - IDA PMID:28301459
    - IDA PMID:36309486
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-202939
    - TAS Reactome:R-HSA-265422
    - TAS Reactome:R-HSA-3827958
    - TAS Reactome:R-HSA-419001
    - TAS Reactome:R-HSA-419002
    - TAS Reactome:R-HSA-4224014
    - TAS Reactome:R-HSA-5672304
    - TAS Reactome:R-HSA-8876497
    - TAS Reactome:R-HSA-8876948
    - TAS Reactome:R-HSA-8876993
    - TAS Reactome:R-HSA-8877003
    - TAS Reactome:R-HSA-9766219
    - TAS Reactome:R-HSA-9766227
    - TAS Reactome:R-HSA-9816278
    - TAS Reactome:R-HSA-9817325
    - TAS Reactome:R-HSA-9817330
    - TAS Reactome:R-HSA-9825774
    - TAS Reactome:R-HSA-9926527
    - TAS Reactome:R-HSA-9934294
    - TAS Reactome:R-HSA-9934410
    - TAS Reactome:R-HSA-9934411
    - TAS Reactome:R-HSA-9934486
    - TAS Reactome:R-HSA-9934584
    - TAS Reactome:R-HSA-9934751
    - TAS Reactome:R-HSA-9934752
    - TAS Reactome:R-HSA-9934753
    - TAS Reactome:R-HSA-9934755
    - TAS Reactome:R-NUL-2534209
  - term: GO:0005912 adherens junction
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005912 adherens junction
    qualifier: located_in
    evidence:
    - IDA PMID:16338932
    - IDA PMID:18343367
    - IDA PMID:20086044
    - IDA PMID:22294297
    - IDA PMID:24046456
    - IDA PMID:27760340
    - IEA GO_REF:0000044
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:20189993
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IDA PMID:16338932
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16338932
    - IEA GO_REF:0000002
  - term: GO:0016328 lateral plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16338932
    - IDA PMID:17620337
  - term: GO:0016342 catenin complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18593713
  - term: GO:0016600 flotillin complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:24046456
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IDA PMID:24046456
  - term: GO:0030054 cell junction
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:19038973
    - IDA PMID:28169360
    - IEA GO_REF:0000117
    - TAS PMID:17047063
  - term: GO:0030057 desmosome
    qualifier: located_in
    evidence:
    - IDA PMID:29999492
    - IDA PMID:33596089
    - IEA GO_REF:0000044
  - term: GO:0030864 cortical actin cytoskeleton
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:24046456
  - term: GO:0031901 early endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9766223
    - TAS Reactome:R-HSA-9934584
    - TAS Reactome:R-HSA-9934752
    - TAS Reactome:R-HSA-9935552
  - term: GO:0043296 apical junction complex
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043296 apical junction complex
    qualifier: located_in
    evidence:
    - IDA PMID:10460003
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16338932
  - term: GO:0098794 postsynapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: CDK1
  row_index: 177
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal presence is not a core function or localization.
  uniprot_subcellular_location: Nucleus {ECO:0000250|UniProtKB:P11440}. Cytoplasm {ECO:0000250|UniProtKB:P11440}. Mitochondrion
    {ECO:0000269|PubMed:19917720}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
    Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during
    prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to
    nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested
    cells upon DN ...
  uniprot_function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well
    as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150,
    PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, P ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000307 cyclin-dependent protein kinase holoenzyme complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:1312467
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:16109376
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: part_of
    evidence:
    - IDA PMID:15767402
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-170044
    - TAS Reactome:R-HSA-170070
    - TAS Reactome:R-HSA-170072
    - TAS Reactome:R-HSA-170076
    - TAS Reactome:R-HSA-170087
    - TAS Reactome:R-HSA-170088
    - TAS Reactome:R-HSA-170131
    - TAS Reactome:R-HSA-170153
    - TAS Reactome:R-HSA-170156
    - TAS Reactome:R-HSA-170158
    - TAS Reactome:R-HSA-174122
    - TAS Reactome:R-HSA-174132
    - TAS Reactome:R-HSA-174251
    - TAS Reactome:R-HSA-2245218
    - TAS Reactome:R-HSA-2294600
    - TAS Reactome:R-HSA-380278
    - TAS Reactome:R-HSA-4088024
    - TAS Reactome:R-HSA-5195402
    - TAS Reactome:R-HSA-5244669
    - TAS Reactome:R-HSA-5692755
    - TAS Reactome:R-HSA-6793661
    - TAS Reactome:R-HSA-9009282
    - TAS Reactome:R-HSA-9929514
    - TAS Reactome:R-HSA-9929533
    - TAS Reactome:R-HSA-9929535
    - TAS Reactome:R-HSA-9929717
    - TAS Reactome:R-HSA-9929719
    - TAS Reactome:R-HSA-9929720
    - TAS Reactome:R-HSA-9929721
    - TAS Reactome:R-HSA-9929884
    - TAS Reactome:R-HSA-9929904
    - TAS Reactome:R-HSA-9929935
    - TAS Reactome:R-NUL-2434198
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: part_of
    evidence:
    - IDA PMID:15767402
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS PMID:19917720
  - term: GO:0005759 mitochondrial matrix
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:24746669
    - IEA GO_REF:0000107
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8940100
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA PMID:17488717
    - IEA GO_REF:0000044
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-112342
    - TAS Reactome:R-HSA-170044
    - TAS Reactome:R-HSA-170055
    - TAS Reactome:R-HSA-170057
    - TAS Reactome:R-HSA-170072
    - TAS Reactome:R-HSA-170088
    - TAS Reactome:R-HSA-170116
    - TAS Reactome:R-HSA-170126
    - TAS Reactome:R-HSA-170131
    - TAS Reactome:R-HSA-170161
    - TAS Reactome:R-HSA-174104
    - TAS Reactome:R-HSA-174120
    - TAS Reactome:R-HSA-174157
    - TAS Reactome:R-HSA-174171
    - TAS Reactome:R-HSA-174227
    - TAS Reactome:R-HSA-174255
    - TAS Reactome:R-HSA-2468287
    - TAS Reactome:R-HSA-2468293
    - TAS Reactome:R-HSA-2574840
    - TAS Reactome:R-HSA-2574845
    - TAS Reactome:R-HSA-2984220
    - TAS Reactome:R-HSA-2990882
    - TAS Reactome:R-HSA-3000310
    - TAS Reactome:R-HSA-3000319
    - TAS Reactome:R-HSA-380272
    - TAS Reactome:R-HSA-380283
    - TAS Reactome:R-HSA-380294
    - TAS Reactome:R-HSA-380303
    - TAS Reactome:R-HSA-380311
    - TAS Reactome:R-HSA-380316
    - TAS Reactome:R-HSA-380455
    - TAS Reactome:R-HSA-380508
    - TAS Reactome:R-HSA-4086410
    - TAS Reactome:R-HSA-5617816
    - TAS Reactome:R-HSA-5626220
    - TAS Reactome:R-HSA-5626223
    - TAS Reactome:R-HSA-5626227
    - TAS Reactome:R-HSA-5626228
    - TAS Reactome:R-HSA-5626681
    - TAS Reactome:R-HSA-5626699
    - TAS Reactome:R-HSA-5638009
    - TAS Reactome:R-HSA-6803875
    - TAS Reactome:R-HSA-8853405
    - TAS Reactome:R-HSA-8853419
    - TAS Reactome:R-HSA-9624800
    - TAS Reactome:R-HSA-9836184
    - TAS Reactome:R-HSA-9928875
    - TAS Reactome:R-HSA-9928887
    - TAS Reactome:R-HSA-9929532
    - TAS Reactome:R-HSA-9929533
    - TAS Reactome:R-NUL-2422970
  - term: GO:0005876 spindle microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:11069302
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - IDA PMID:11069302
  - term: GO:0072686 mitotic spindle
    qualifier: located_in
    evidence:
    - IDA PMID:17488717
  - term: GO:0097125 cyclin B1-CDK1 complex
    qualifier: part_of
    evidence:
    - IMP PMID:24746669
- organism: human
  gene: CHMP1A
  row_index: 82
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes may reflect ESCRT-III role in MVB/exosome biogenesis or could be incidental. Not a
    core localization.
  uniprot_subcellular_location: Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic
    form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome
    scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed
    chromatin.
  uniprot_function: Probable peripherally associated component of the endosomal sorting required for transport complex III
    (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.
    MVBs contain intraluminal vesicles (ILVs) that are generated by invaginati ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0000794 condensed nuclear chromosome
    qualifier: located_in
    evidence:
    - IDA PMID:11559747
  - term: GO:0000815 ESCRT III complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005643 nuclear pore
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IDA PMID:11559748
  - term: GO:0005771 multivesicular body
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005815 microtubule organizing center
    qualifier: located_in
    evidence:
    - IDA PMID:11559748
  - term: GO:0005828 kinetochore microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-9610942
    - TAS Reactome:R-HSA-9610954
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0012505 endomembrane system
    qualifier: located_in
    evidence:
    - IDA PMID:11559748
  - term: GO:0016363 nuclear matrix
    qualifier: located_in
    evidence:
    - IDA PMID:11559747
    - IEA GO_REF:0000044
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16554368
    - IEA GO_REF:0000117
  - term: GO:1904930 amphisome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
- organism: human
  gene: CHMP2A
  row_index: 78
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection expected given ESCRT role in exosome biogenesis.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral
    membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941,
    ECO:0000269|PubMed:17853893}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Note=Localizes to the midbody of dividing
    cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope
    on chromatin disks during late anaphase (PubMed:28242692). {ECO:0000269|PubMed:28242692}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: &id055 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id056
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0000785 chromatin
    qualifier: located_in
    evidence:
    - IDA PMID:28242692
  - term: GO:0000815 ESCRT III complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18687924
    - IDA PMID:26040712
    - TAS PMID:20588296
  - term: GO:0005635 nuclear envelope
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000044
  - term: GO:0005643 nuclear pore
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
  - term: GO:0005771 multivesicular body
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005828 kinetochore microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-5671702
    - TAS Reactome:R-HSA-917693
    - TAS Reactome:R-HSA-917700
    - TAS Reactome:R-HSA-9668389
    - TAS Reactome:R-HSA-9668395
    - TAS Reactome:R-HSA-9668398
    - TAS Reactome:R-HSA-9668405
    - TAS Reactome:R-HSA-9668415
    - TAS Reactome:R-HSA-9668419
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
  - term: GO:0030117 membrane coat
    qualifier: part_of
    evidence:
    - IMP PMID:24878737
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16554368
    - IEA GO_REF:0000117
  - term: GO:1904930 amphisome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
- organism: human
  gene: CHMP2A
  row_index: 79
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection expected given ESCRT role in exosome biogenesis.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral
    membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941,
    ECO:0000269|PubMed:17853893}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Note=Localizes to the midbody of dividing
    cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope
    on chromatin disks during late anaphase (PubMed:28242692). {ECO:0000269|PubMed:28242692}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: *id055
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id056
- organism: human
  gene: CHMP2A
  row_index: 80
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection expected given ESCRT role in exosome biogenesis.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral
    membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941,
    ECO:0000269|PubMed:17853893}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Note=Localizes to the midbody of dividing
    cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope
    on chromatin disks during late anaphase (PubMed:28242692). {ECO:0000269|PubMed:28242692}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: *id055
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id056
- organism: human
  gene: CHMP2B
  row_index: 85
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ESCRT-III may be captured in exosomes during MVB-plasma membrane fusion but is not a core exosome component.
    This may reflect co-fractionation during exosome biogenesis.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373};
    Peripheral membrane protein {ECO:0000305|PubMed:16041373}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: &id057 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id058
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0000815 ESCRT III complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:24878737
    - TAS PMID:20588296
    - TAS PMID:21118109
  - term: GO:0005643 nuclear pore
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
    - IDA PMID:25468996
  - term: GO:0005764 lysosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:16041373
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
  - term: GO:0005768 endosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:24878737
  - term: GO:0005770 late endosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:16041373
  - term: GO:0005771 multivesicular body
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005828 kinetochore microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:16041373
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917693
    - TAS Reactome:R-HSA-917700
    - TAS Reactome:R-HSA-9668389
    - TAS Reactome:R-HSA-9668395
    - TAS Reactome:R-HSA-9668398
    - TAS Reactome:R-HSA-9668405
    - TAS Reactome:R-HSA-9668415
    - TAS Reactome:R-HSA-9668419
  - term: GO:0005886 plasma membrane
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:24878737
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16554368
    - IEA GO_REF:0000117
  - term: GO:1904930 amphisome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
- organism: human
  gene: CHMP2B
  row_index: 87
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same as above - likely co-fractionation during exosome biogenesis.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373};
    Peripheral membrane protein {ECO:0000305|PubMed:16041373}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: *id057
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id058
- organism: human
  gene: CHMP4B
  row_index: 111
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: CHMP4B/ESCRT biology supports exosome release, but high-throughput extracellular exosome localization is
    broad and secondary to the core ESCRT-III MVB membrane-remodeling function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15511219}. Late endosome membrane {ECO:0000269|PubMed:15511219,
    ECO:0000305|PubMed:12860994}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22422861}.
    Nucleus envelope {ECO:0000269|PubMed:26040712}. Note=Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712).
    Localizes transiently to the midbody arms immediately before abscission (PubMed:22422861). {ECO:0000269|PubMed:22422861,
    ECO:0000269|PubMed:26040712}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: &id059 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id060
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0000815 ESCRT III complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18209100
    - IDA PMID:21310966
    - IDA PMID:21975012
    - IDA PMID:24878737
    - IDA PMID:26040712
    - NAS PMID:36107470
    - TAS PMID:20588296
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:21975012
  - term: GO:0005635 nuclear envelope
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005635 nuclear envelope
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000044
  - term: GO:0005643 nuclear pore
    qualifier: part_of
    evidence:
    - IDA PMID:26040713
    - IEA GO_REF:0000117
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:17701905
    - IDA PMID:21975012
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:17701905
  - term: GO:0005828 kinetochore microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917693
    - TAS Reactome:R-HSA-917700
    - TAS Reactome:R-HSA-9668389
    - TAS Reactome:R-HSA-9668395
    - TAS Reactome:R-HSA-9668398
    - TAS Reactome:R-HSA-9668405
    - TAS Reactome:R-HSA-9668415
    - TAS Reactome:R-HSA-9668419
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:18209100
  - term: GO:0030117 membrane coat
    qualifier: part_of
    evidence:
    - IDA PMID:24878737
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - EXP PMID:22422861
    - IDA PMID:21310966
    - IDA PMID:22724069
    - IDA PMID:26040712
    - IEA GO_REF:0000120
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:15511219
    - IEA GO_REF:0000044
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:25468996
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16554368
    - IEA GO_REF:0000117
  - term: GO:1904930 amphisome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
- organism: human
  gene: CHMP4B
  row_index: 121
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: CHMP4B/ESCRT biology supports exosome release, but high-throughput extracellular exosome localization is
    broad and secondary to the core ESCRT-III MVB membrane-remodeling function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15511219}. Late endosome membrane {ECO:0000269|PubMed:15511219,
    ECO:0000305|PubMed:12860994}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22422861}.
    Nucleus envelope {ECO:0000269|PubMed:26040712}. Note=Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712).
    Localizes transiently to the midbody arms immediately before abscission (PubMed:22422861). {ECO:0000269|PubMed:22422861,
    ECO:0000269|PubMed:26040712}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: *id059
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id060
- organism: human
  gene: CHMP4B
  row_index: 123
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: CHMP4B/ESCRT biology supports exosome release, but high-throughput extracellular exosome localization is
    broad and secondary to the core ESCRT-III MVB membrane-remodeling function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15511219}. Late endosome membrane {ECO:0000269|PubMed:15511219,
    ECO:0000305|PubMed:12860994}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22422861}.
    Nucleus envelope {ECO:0000269|PubMed:26040712}. Note=Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712).
    Localizes transiently to the midbody arms immediately before abscission (PubMed:22422861). {ECO:0000269|PubMed:22422861,
    ECO:0000269|PubMed:26040712}.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: *id059
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id060
- organism: human
  gene: CHMP5
  row_index: 78
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput exosome proteomics can be compatible with ESCRT/exosome biology, but it does not establish
    the CHMP5 core cellular function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305}; Peripheral
    membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells
    (PubMed:17853893). Localized in two distinct rings on either side of the Flemming body (PubMed:17853893). {ECO:0000269|PubMed:17853893}.
  uniprot_function: Probable peripherally associated component of the endosomal sorting required for transport complex III
    (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.
    MVBs contain intraluminal vesicles (ILVs) that are generated by invaginati ...
  uniprot_features: &id061
  - LIPID
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id062
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0000815 ESCRT III complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - NAS PMID:36107470
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005635 nuclear envelope
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005643 nuclear pore
    qualifier: part_of
    evidence:
    - IDA PMID:26040713
    - IEA GO_REF:0000117
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
  - term: GO:0005828 kinetochore microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:15644320
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917693
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0015630 microtubule cytoskeleton
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - EXP PMID:17853893
    - IDA GO_REF:0000052
    - IDA PMID:26040712
    - IEA GO_REF:0000120
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16554368
    - IEA GO_REF:0000117
  - term: GO:1904930 amphisome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
- organism: human
  gene: CHMP5
  row_index: 79
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput exosome proteomics can be compatible with ESCRT/exosome biology, but it does not establish
    the CHMP5 core cellular function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305}; Peripheral
    membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells
    (PubMed:17853893). Localized in two distinct rings on either side of the Flemming body (PubMed:17853893). {ECO:0000269|PubMed:17853893}.
  uniprot_function: Probable peripherally associated component of the endosomal sorting required for transport complex III
    (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.
    MVBs contain intraluminal vesicles (ILVs) that are generated by invaginati ...
  uniprot_features: *id061
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id062
- organism: human
  gene: CHMP5
  row_index: 80
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput exosome proteomics can be compatible with ESCRT/exosome biology, but it does not establish
    the CHMP5 core cellular function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305}; Peripheral
    membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells
    (PubMed:17853893). Localized in two distinct rings on either side of the Flemming body (PubMed:17853893). {ECO:0000269|PubMed:17853893}.
  uniprot_function: Probable peripherally associated component of the endosomal sorting required for transport complex III
    (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.
    MVBs contain intraluminal vesicles (ILVs) that are generated by invaginati ...
  uniprot_features: *id061
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id062
- organism: human
  gene: CHMP6
  row_index: 73
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular exosome localization from high-throughput proteomics is compatible with ESCRT biology but
    does not define the CHMP6 core function in MVB cargo sorting.
  uniprot_subcellular_location: Endomembrane system. Endosome membrane; Lipid- anchor. Late endosome membrane {ECO:0000305}.
    Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes to endosomal membranes.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: &id063
  - LIPID
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id064
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0000815 ESCRT III complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:24878737
    - NAS PMID:36107470
    - TAS PMID:20588296
  - term: GO:0005635 nuclear envelope
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005643 nuclear pore
    qualifier: part_of
    evidence:
    - IDA PMID:26040713
    - IEA GO_REF:0000117
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
  - term: GO:0005828 kinetochore microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917693
    - TAS Reactome:R-HSA-917700
    - TAS Reactome:R-HSA-9668389
    - TAS Reactome:R-HSA-9668395
    - TAS Reactome:R-HSA-9668398
    - TAS Reactome:R-HSA-9668405
    - TAS Reactome:R-HSA-9668415
    - TAS Reactome:R-HSA-9668419
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24878737
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16973552
    - IEA GO_REF:0000044
  - term: GO:0012505 endomembrane system
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - IDA PMID:26040712
    - IEA GO_REF:0000117
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16554368
    - IEA GO_REF:0000117
  - term: GO:1904930 amphisome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17984323
    - IEA GO_REF:0000117
- organism: human
  gene: CHMP6
  row_index: 74
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular exosome localization from high-throughput proteomics is compatible with ESCRT biology but
    does not define the CHMP6 core function in MVB cargo sorting.
  uniprot_subcellular_location: Endomembrane system. Endosome membrane; Lipid- anchor. Late endosome membrane {ECO:0000305}.
    Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes to endosomal membranes.
  uniprot_function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which
    is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission fro ...
  uniprot_features: *id063
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id064
- organism: human
  gene: CKB
  row_index: 31
  term: GO:0070062 extracellular exosome
  reference: PMID:11487543
  reference_title: Intestinal epithelial cells secrete exosome-like vesicles.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is common for abundant cytosolic enzymes; retain as a non-core localization, not a site
    of creatine kinase function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}.
    Cell membrane {ECO:0000269|PubMed:18566107}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal
    MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
  uniprot_function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate)
    (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating
    energy demands, such as skeletal muscle, heart, brain and spermatozo ...
  uniprot_features: &id065 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id066
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005739 mitochondrion
    qualifier: is_active_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-200318
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:18566107
    - IEA GO_REF:0000044
- organism: human
  gene: CKB
  row_index: 34
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic exosome detection; non-core localization, not a functional compartment for catalysis.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}.
    Cell membrane {ECO:0000269|PubMed:18566107}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal
    MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
  uniprot_function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate)
    (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating
    energy demands, such as skeletal muscle, heart, brain and spermatozo ...
  uniprot_features: *id065
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id066
- organism: human
  gene: CKB
  row_index: 36
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic exosome detection; non-core localization.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}.
    Cell membrane {ECO:0000269|PubMed:18566107}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal
    MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
  uniprot_function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate)
    (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating
    energy demands, such as skeletal muscle, heart, brain and spermatozo ...
  uniprot_features: *id065
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id066
- organism: human
  gene: CLTC
  row_index: 97
  term: GO:0070062 extracellular exosome
  reference: PMID:12519789
  reference_title: Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function
    and multivesicular body formation.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Clathrin presence in exosomes likely reflects its abundance in endocytic pathway rather than a specific
    exosome function. This is not a core function of clathrin.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: &id067 []
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: &id068
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005802 trans-Golgi network
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005819 spindle
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IDA PMID:15858577
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2130619
    - TAS Reactome:R-HSA-2213236
    - TAS Reactome:R-HSA-421831
    - TAS Reactome:R-HSA-421835
    - TAS Reactome:R-HSA-421836
    - TAS Reactome:R-HSA-432688
    - TAS Reactome:R-HSA-432706
    - TAS Reactome:R-HSA-432707
    - TAS Reactome:R-HSA-8856808
    - TAS Reactome:R-HSA-8856813
    - TAS Reactome:R-HSA-8862280
    - TAS Reactome:R-HSA-8866283
    - TAS Reactome:R-HSA-8867754
    - TAS Reactome:R-HSA-8867756
    - TAS Reactome:R-HSA-8868071
    - TAS Reactome:R-HSA-8868072
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
    - TAS Reactome:R-HSA-8871196
    - TAS Reactome:R-HSA-8951498
    - TAS Reactome:R-HSA-9700131
    - TAS Reactome:R-HSA-9700179
    - TAS Reactome:R-HSA-9700181
    - TAS Reactome:R-HSA-9712078
    - TAS Reactome:R-HSA-9712079
    - TAS Reactome:R-HSA-9712083
    - TAS Reactome:R-HSA-9712084
    - TAS Reactome:R-HSA-9712085
    - TAS Reactome:R-HSA-9850958
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-177479
    - TAS Reactome:R-HSA-2130640
    - TAS Reactome:R-HSA-2130725
    - TAS Reactome:R-HSA-392748
    - TAS Reactome:R-HSA-392749
    - TAS Reactome:R-HSA-445071
    - TAS Reactome:R-HSA-445079
    - TAS Reactome:R-HSA-5138433
    - TAS Reactome:R-HSA-5138459
    - TAS Reactome:R-HSA-555065
    - TAS Reactome:R-HSA-6784729
    - TAS Reactome:R-HSA-6784735
    - TAS Reactome:R-HSA-8855130
    - TAS Reactome:R-HSA-8855131
    - TAS Reactome:R-HSA-8866279
    - TAS Reactome:R-HSA-8867754
    - TAS Reactome:R-HSA-8867756
    - TAS Reactome:R-HSA-8868071
    - TAS Reactome:R-HSA-8868072
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868661
  - term: GO:0005905 clathrin-coated pit
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000043
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030118 clathrin coat
    qualifier: part_of
    evidence:
    - IMP PMID:11756460
    - NAS PMID:1765375
  - term: GO:0030130 clathrin coat of trans-Golgi network vesicle
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0030132 clathrin coat of coated pit
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0030136 clathrin-coated vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:19478182
    - IEA GO_REF:0000117
  - term: GO:0030659 cytoplasmic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030669 clathrin-coated endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5138459
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000043
  - term: GO:0032588 trans-Golgi network membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2130641
    - TAS Reactome:R-HSA-2213236
    - TAS Reactome:R-HSA-5333658
    - TAS Reactome:R-HSA-8951498
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:21266579
  - term: GO:0036020 endolysosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2130486
    - TAS Reactome:R-HSA-2130725
    - TAS Reactome:R-HSA-6784729
    - TAS Reactome:R-HSA-6784738
    - TAS Reactome:R-HSA-8855130
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0045334 clathrin-coated endocytic vesicle
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045334 clathrin-coated endocytic vesicle
    qualifier: located_in
    evidence:
    - NAS PMID:25898166
  - term: GO:0071439 clathrin complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:4066749
    - IEA GO_REF:0000002
  - term: GO:0072686 mitotic spindle
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:1990498 mitotic spindle microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:21297582
- organism: human
  gene: CLTC
  row_index: 99
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Clathrin presence in extracellular vesicles reflects endocytic pathway involvement rather than a specific
    EV function.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: *id067
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id068
- organism: human
  gene: CLTC
  row_index: 102
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same reasoning as other exosome annotations - reflects clathrin abundance in endocytic pathway rather than
    specific function.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: *id067
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id068
- organism: human
  gene: CLTC
  row_index: 136
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome presence reflects endocytic pathway abundance, not specific function.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: *id067
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id068
- organism: human
  gene: CLTC
  row_index: 137
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same reasoning as other exosome annotations.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: *id067
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id068
- organism: human
  gene: CLTC
  row_index: 139
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same reasoning as other exosome annotations.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: *id067
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id068
- organism: human
  gene: CLTC
  row_index: 152
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same reasoning as other exosome annotations.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065};
    Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane
    protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}.
    Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions fro ...
  uniprot_function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter
    protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component
    of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabili ...
  uniprot_features: *id067
  gene_vesicle_rows: 7
  gene_vesicle_references: 7
  leads: *id068
- organism: human
  gene: COASY
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:24360804, ECO:0000269|PubMed:40925986}. Mitochondrion
    matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly cytosolic and active in the cytosol (PubMed:40925986).
    Present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane (PubMed:24360804). {ECO:0000269|PubMed:24360804,
    ECO:0000269|PubMed:40925986}.
  uniprot_function: Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation
    of 4'- phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA. {ECO:0000269|PubMed:11923312,
    ECO:0000269|PubMed:24360804}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005741 mitochondrial outer membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-196754
    - TAS Reactome:R-HSA-196773
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IDA PMID:24360804
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IDA PMID:40925986
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: COMP
  row_index: 60
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection may reflect COMP release during tissue turnover rather than primary exosomal function.
    Not a core localization.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:32686688}.
  uniprot_function: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix
    proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular
    matrix through interaction with cell surface integrin receptors (PubM ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:32747625
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-2424252
    - TAS Reactome:R-HSA-2426259
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031012 extracellular matrix
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IDA PMID:18285447
    - TAS PMID:7713493
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: COPS8
  row_index: 39
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: While COPS8 may be present in exosomes based on proteomics data, this does not represent a core functional
    localization. The primary sites of CSN function are nucleus and cytoplasm.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
  uniprot_function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental
    processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation
    of the cullin subunits of SCF- type E3 ligase complexes, leading to ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:24421388
    - IEA GO_REF:0000120
    - TAS PMID:8689678
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-5691006
    - TAS Reactome:R-HSA-6781833
    - TAS Reactome:R-HSA-8956045
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:24421388
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-8863721
    - TAS Reactome:R-HSA-8863723
    - TAS Reactome:R-HSA-8956040
  - term: GO:0008180 COP9 signalosome
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18850735
    - IDA PMID:9535219
    - IEA GO_REF:0000120
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:9535219
- organism: human
  gene: CRISPLD1
  row_index: 4
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: 'The HDA observation is retained as context-specific localization evidence and is consistent with CRISPLD1
    secretion. It does not establish that CRISPLD1 is a constitutive exosome component or functions on/in vesicles: the study
    used a high-complexity ultracentrifugation preparation and explicitly notes that some proteins may also occur in soluble
    form.'
  uniprot_subcellular_location: Secreted {ECO:0000305}.
  uniprot_function: ''
  uniprot_features: &id069
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id070
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
- organism: human
  gene: CRISPLD1
  row_index: 6
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This independent extracellular-fluid proteome corroborates secretion and supports retaining the HDA observation.
    It remains non-core because the study does not establish CRISPLD1's vesicle topology or function and explicitly acknowledges
    that abundant secreted proteins can be incorporated during vesicle formation or arise from minor preparation contamination.
  uniprot_subcellular_location: Secreted {ECO:0000305}.
  uniprot_function: ''
  uniprot_features: *id069
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id070
- organism: human
  gene: CSK
  row_index: 80
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Large-scale detection of a cytosolic protein in exosomes; not a functional location.
  uniprot_subcellular_location: Cytoplasm {ECO:0000250|UniProtKB:P41241}. Cell membrane {ECO:0000250|UniProtKB:P41241}. Note=Mainly
    cytoplasmic, also present in lipid rafts. {ECO:0000250|UniProtKB:P41241}.
  uniprot_function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation,
    migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases
    (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS PMID:8890164
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-202233
    - TAS Reactome:R-HSA-203774
    - TAS Reactome:R-HSA-354077
    - TAS Reactome:R-HSA-354149
    - TAS Reactome:R-HSA-377641
    - TAS Reactome:R-HSA-377644
    - TAS Reactome:R-HSA-389758
    - TAS Reactome:R-HSA-389759
    - TAS Reactome:R-HSA-389762
    - TAS Reactome:R-HSA-432096
    - TAS Reactome:R-HSA-443905
    - TAS Reactome:R-HSA-443910
    - TAS Reactome:R-HSA-8855375
    - TAS Reactome:R-HSA-9018758
    - TAS Reactome:R-HSA-9706298
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - IPI PMID:10790433
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-177923
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: CUBN
  row_index: 40
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes is a byproduct of cubilin's abundant apical membrane localization and its shedding
    into urine; not a functional localization but a valid observation.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000250|UniProtKB:Q9JLB4}; Peripheral membrane protein {ECO:0000305}.
    Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}; Peripheral membrane
    protein {ECO:0000305, ECO:0000305|PubMed:30523278}. Membrane, coated pit {ECO:0000269|PubMed:14576052}. Endosome {ECO:0000269|PubMed:14576052,
    ECO:0000269|PubMed:29402915}. Lysosome membrane {ECO:0000250|UniProtKB:O70244}; Peripheral membrane protein {ECO:0000305}.
    Note=Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (PubMed:2 ...
  uniprot_function: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their
    uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993). Acts together with LRP2 to
    mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF an ...
  uniprot_features: &id071
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id072
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - EXP PMID:14576052
    - EXP PMID:29402915
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-209760
    - TAS Reactome:R-HSA-350168
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:14576052
    - EXP PMID:29402915
    - EXP PMID:30523278
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-264834
    - TAS Reactome:R-HSA-264848
    - TAS Reactome:R-HSA-3000103
    - TAS Reactome:R-HSA-3000137
    - TAS Reactome:R-HSA-3296462
    - TAS Reactome:R-HSA-3296477
    - TAS Reactome:R-HSA-350168
    - TAS Reactome:R-HSA-350186
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000044
    - TAS PMID:9478979
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - NAS PMID:14576052
  - term: GO:0030139 endocytic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
    - IEA GO_REF:0000117
  - term: GO:0031232 extrinsic component of external side of plasma membrane
    qualifier: located_in
    evidence:
    - NAS PMID:11994745
  - term: GO:0031253 cell projection membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0031526 brush border membrane
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
    - NAS PMID:11994745
  - term: GO:0031528 microvillus membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:14576052
  - term: GO:0031528 microvillus membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14576052
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-209760
    - TAS Reactome:R-HSA-350158
  - term: GO:0043235 signaling receptor complex
    qualifier: part_of
    evidence:
    - IPI PMID:30523278
    - ISS GO_REF:0000024
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:21082674
- organism: human
  gene: CUBN
  row_index: 43
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with cubilin's abundance at the apical surface of renal epithelia and its shedding into urinary
    exosomes; a non-functional localization observation.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000250|UniProtKB:Q9JLB4}; Peripheral membrane protein {ECO:0000305}.
    Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}; Peripheral membrane
    protein {ECO:0000305, ECO:0000305|PubMed:30523278}. Membrane, coated pit {ECO:0000269|PubMed:14576052}. Endosome {ECO:0000269|PubMed:14576052,
    ECO:0000269|PubMed:29402915}. Lysosome membrane {ECO:0000250|UniProtKB:O70244}; Peripheral membrane protein {ECO:0000305}.
    Note=Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (PubMed:2 ...
  uniprot_function: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their
    uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993). Acts together with LRP2 to
    mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF an ...
  uniprot_features: *id071
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id072
- organism: human
  gene: DDC
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan
    to serotonin. {ECO:0000250|UniProtKB:P80041}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-209859
    - TAS Reactome:R-HSA-209924
- organism: human
  gene: DNAJA2
  row_index: 30
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in urinary exosomes via large-scale proteomics (PMID:19056867) is technically valid but represents
    a secondary observation rather than a core functional localization. Many abundant cytosolic proteins are detected in exosome
    preparations. DNAJA2's primary function is as a cytosolic HSP70 co-chaperone.
  uniprot_subcellular_location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
  uniprot_function: Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B
    (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}.
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21231916
    - TAS Reactome:R-HSA-3371422
    - TAS Reactome:R-HSA-3371503
    - TAS Reactome:R-HSA-3371590
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: DNAJB1
  row_index: 65
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in extracellular exosomes by proteomics (PMID:19056867) is valid but represents a non-specific
    finding. Many cytosolic proteins are found in exosomes without specific functional significance. Keep as non-core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:1586970}. Nucleus {ECO:0000269|PubMed:1586970}. Nucleus, nucleolus
    {ECO:0000269|PubMed:1586970}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli,
    upon heat shock.
  uniprot_function: Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter
    that regulates HSP70- dependent folding process by interacting with the HSP70 amino terminal region (PubMed:14503850).
    Stimulates the association between HSC70 and HIP. Negatively regulates heat sh ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-3371467
    - TAS Reactome:R-HSA-3371518
    - TAS Reactome:R-HSA-3371554
    - TAS Reactome:R-HSA-5082356
    - TAS Reactome:R-HSA-5082369
    - TAS Reactome:R-HSA-5082384
    - TAS Reactome:R-HSA-5251955
  - term: GO:0005730 nucleolus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:25468996
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:21231916
    - TAS Reactome:R-HSA-5251959
    - TAS Reactome:R-HSA-5690245
    - TAS Reactome:R-HSA-5690250
  - term: GO:0014069 postsynaptic density
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043197 dendritic spine
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0061827 sperm head
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098794 postsynapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: DNAJC13
  row_index: 23
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Bulk exosome-proteomics detection; plausible given endosomal origin of exosomes but peripheral to the gene's
    core function.
  uniprot_subcellular_location: Early endosome {ECO:0000269|PubMed:18256511}. Early endosome membrane {ECO:0000305}; Peripheral
    membrane protein {ECO:0000269|PubMed:18256511}. Endosome membrane {ECO:0000269|PubMed:24643499}.
  uniprot_function: Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome
    transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation
    of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in  ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - EXP PMID:18256511
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
    - TAS Reactome:R-HSA-6798743
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:24643499
    - IEA GO_REF:0000044
  - term: GO:0030667 secretory granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0031901 early endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:18256511
    - IEA GO_REF:0000044
  - term: GO:0035577 azurophil granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
  - term: GO:0071203 WASH complex
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:24643499
- organism: human
  gene: DNAJC3
  row_index: 27
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic vesicle detection; not reflective of DNAJC3's principal ER co-chaperone role.
  uniprot_subcellular_location: Endoplasmic reticulum {ECO:0000250}.
  uniprot_function: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative
    regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence
    attenuating general protein synthesis under ER stress, hypothermic and am ...
  uniprot_features: &id073
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id074
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS PMID:8666242
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-1791157
    - TAS Reactome:R-HSA-8952289
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-9835454
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
- organism: human
  gene: DNAJC3
  row_index: 30
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic exosome detection; not reflective of DNAJC3's principal ER co-chaperone role.
  uniprot_subcellular_location: Endoplasmic reticulum {ECO:0000250}.
  uniprot_function: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative
    regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence
    attenuating general protein synthesis under ER stress, hypothermic and am ...
  uniprot_features: *id073
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id074
- organism: human
  gene: DPEP1
  row_index: 32
  term: GO:0070062 extracellular exosome
  reference: PMID:11487543
  reference_title: Intestinal epithelial cells secrete exosome-like vesicles.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The exosome localization is a real but secondary finding from high-throughput proteomics; it reflects vesicle
    shedding of an apical membrane protein rather than the functional site of DPEP1 (brush-border/microvillus membrane). Retain
    as non-core.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:28413640}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}.
    Cell projection, microvillus membrane {ECO:0000269|PubMed:2168407}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}.
    Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
  uniprot_function: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490,
    PubMed:31442408, PubMed:32325220, PubMed:6334084). Hydrolyzes cystinyl- bis-glycine (cys-bis-gly) formed during glutathione
    degradation (PubMed:32325220). Also possesses beta lactamase ...
  uniprot_features: &id075
  - LIPID
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id076
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:12144777
    - TAS PMID:20031578
    - TAS Reactome:R-HSA-266012
    - TAS Reactome:R-HSA-5433067
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030054 cell junction
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0031528 microvillus membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0045177 apical part of cell
    qualifier: located_in
    evidence:
    - IDA PMID:20824289
  - term: GO:0098552 side of membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000043
- organism: human
  gene: DPEP1
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This high-throughput exosome detection reflects vesicle shedding rather than the functional brush-border
    location of DPEP1; keep as non-core localization context.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:28413640}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}.
    Cell projection, microvillus membrane {ECO:0000269|PubMed:2168407}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}.
    Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
  uniprot_function: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490,
    PubMed:31442408, PubMed:32325220, PubMed:6334084). Hydrolyzes cystinyl- bis-glycine (cys-bis-gly) formed during glutathione
    degradation (PubMed:32325220). Also possesses beta lactamase ...
  uniprot_features: *id075
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id076
- organism: human
  gene: DPEP1
  row_index: 34
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput urinary exosome proteomics localization is secondary to DPEP1's functional brush-border
    membrane site; keep as non-core context.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:28413640}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}.
    Cell projection, microvillus membrane {ECO:0000269|PubMed:2168407}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}.
    Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
  uniprot_function: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490,
    PubMed:31442408, PubMed:32325220, PubMed:6334084). Hydrolyzes cystinyl- bis-glycine (cys-bis-gly) formed during glutathione
    degradation (PubMed:32325220). Also possesses beta lactamase ...
  uniprot_features: *id075
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id076
- organism: human
  gene: DPYS
  row_index: 12
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic detection in secreted exosomes; peripheral to the enzyme's cytosolic metabolic role rather than
    a functional localization.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening
    of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine
    to N-carbamyl-amino isobutyrate.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-73589
    - TAS Reactome:R-HSA-73618
- organism: human
  gene: DPYSL2
  row_index: 34
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Plausible but non-core (broad term, division-/synapse-specific, or high-throughput proteomics).
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}.
    Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
  uniprot_function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth
    cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
    May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:20801876
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-399944
    - TAS Reactome:R-HSA-399947
    - TAS Reactome:R-HSA-399951
    - TAS Reactome:R-HSA-443783
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005874 microtubule
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:20801876
  - term: GO:0015630 microtubule cytoskeleton
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0016020 membrane
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:20801876
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0045171 intercellular bridge
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0072686 mitotic spindle
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
- organism: human
  gene: EGF
  row_index: 221
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular exosome is retained as a non-core proteomics-supported location and does not supersede extracellular
    region or plasma membrane as the main EGF localizations.
  uniprot_subcellular_location: Membrane; Single-pass type I membrane protein.
  uniprot_function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some
    fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted
    tubule via engagement of EGFR and activation of the magnesium channel TRPM6 ...
  uniprot_features: &id077
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id078
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IDA PMID:11336639
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:11336639
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1169421
    - TAS Reactome:R-HSA-1220610
    - TAS Reactome:R-HSA-1220611
    - TAS Reactome:R-HSA-1220612
    - TAS Reactome:R-HSA-1220613
    - TAS Reactome:R-HSA-1225947
    - TAS Reactome:R-HSA-1225949
    - TAS Reactome:R-HSA-1225950
    - TAS Reactome:R-HSA-1225951
    - TAS Reactome:R-HSA-1225952
    - TAS Reactome:R-HSA-1225956
    - TAS Reactome:R-HSA-1225957
    - TAS Reactome:R-HSA-1225960
    - TAS Reactome:R-HSA-1225961
    - TAS Reactome:R-HSA-1225978
    - TAS Reactome:R-HSA-1226012
    - TAS Reactome:R-HSA-1226014
    - TAS Reactome:R-HSA-1226016
    - TAS Reactome:R-HSA-1247841
    - TAS Reactome:R-HSA-1247842
    - TAS Reactome:R-HSA-1247844
    - TAS Reactome:R-HSA-1250195
    - TAS Reactome:R-HSA-1306957
    - TAS Reactome:R-HSA-1306963
    - TAS Reactome:R-HSA-1306965
    - TAS Reactome:R-HSA-177922
    - TAS Reactome:R-HSA-177923
    - TAS Reactome:R-HSA-177924
    - TAS Reactome:R-HSA-177925
    - TAS Reactome:R-HSA-177926
    - TAS Reactome:R-HSA-177927
    - TAS Reactome:R-HSA-177930
    - TAS Reactome:R-HSA-177933
    - TAS Reactome:R-HSA-177934
    - TAS Reactome:R-HSA-177935
    - TAS Reactome:R-HSA-177936
    - TAS Reactome:R-HSA-177937
    - TAS Reactome:R-HSA-177938
    - TAS Reactome:R-HSA-177939
    - TAS Reactome:R-HSA-177941
    - TAS Reactome:R-HSA-177942
    - TAS Reactome:R-HSA-177943
    - TAS Reactome:R-HSA-177944
    - TAS Reactome:R-HSA-177945
    - TAS Reactome:R-HSA-182969
    - TAS Reactome:R-HSA-182986
    - TAS Reactome:R-HSA-182990
    - TAS Reactome:R-HSA-182993
    - TAS Reactome:R-HSA-182994
    - TAS Reactome:R-HSA-183002
    - TAS Reactome:R-HSA-183036
    - TAS Reactome:R-HSA-183051
    - TAS Reactome:R-HSA-183055
    - TAS Reactome:R-HSA-183058
    - TAS Reactome:R-HSA-183067
    - TAS Reactome:R-HSA-183072
    - TAS Reactome:R-HSA-183084
    - TAS Reactome:R-HSA-183089
    - TAS Reactome:R-HSA-1963563
    - TAS Reactome:R-HSA-1963581
    - TAS Reactome:R-HSA-1963582
    - TAS Reactome:R-HSA-1963586
    - TAS Reactome:R-HSA-1963589
    - TAS Reactome:R-HSA-1977959
    - TAS Reactome:R-HSA-212706
    - TAS Reactome:R-HSA-212710
    - TAS Reactome:R-HSA-212713
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-481007
    - TAS Reactome:R-HSA-5638137
    - TAS Reactome:R-HSA-5672965
    - TAS Reactome:R-HSA-6785636
    - TAS Reactome:R-HSA-6785648
    - TAS Reactome:R-HSA-8847995
    - TAS Reactome:R-HSA-8848005
    - TAS Reactome:R-HSA-8863804
    - TAS Reactome:R-HSA-8864029
    - TAS Reactome:R-HSA-8864105
    - TAS Reactome:R-HSA-8864125
    - TAS Reactome:R-HSA-8866279
    - TAS Reactome:R-HSA-8867041
    - TAS Reactome:R-HSA-8867044
    - TAS Reactome:R-HSA-8867047
    - TAS Reactome:R-HSA-8867754
    - TAS Reactome:R-HSA-8867756
    - TAS Reactome:R-HSA-8868071
    - TAS Reactome:R-HSA-8868072
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8951490
    - TAS Reactome:R-HSA-9018572
    - TAS Reactome:R-HSA-9018573
    - TAS Reactome:R-HSA-9625482
    - TAS Reactome:R-HSA-9625487
    - TAS Reactome:R-HSA-9664567
    - TAS Reactome:R-HSA-9664588
    - TAS Reactome:R-HSA-9664918
    - TAS Reactome:R-HSA-9664933
    - TAS Reactome:R-HSA-9664940
    - TAS Reactome:R-HSA-9664950
    - TAS Reactome:R-HSA-9664976
    - TAS Reactome:R-HSA-9664983
    - TAS Reactome:R-HSA-9664991
    - TAS Reactome:R-HSA-9665000
    - TAS Reactome:R-HSA-9665009
    - TAS Reactome:R-HSA-9665032
    - TAS Reactome:R-HSA-9665034
    - TAS Reactome:R-HSA-9665388
    - TAS Reactome:R-HSA-9665389
    - TAS Reactome:R-HSA-9665404
    - TAS Reactome:R-HSA-9665406
    - TAS Reactome:R-HSA-9665407
    - TAS Reactome:R-HSA-9665408
    - TAS Reactome:R-HSA-9665409
    - TAS Reactome:R-HSA-9665410
    - TAS Reactome:R-HSA-9665411
    - TAS Reactome:R-HSA-9665413
    - TAS Reactome:R-HSA-9665415
    - TAS Reactome:R-HSA-9665416
    - TAS Reactome:R-HSA-9665417
    - TAS Reactome:R-HSA-9665697
    - TAS Reactome:R-HSA-9665698
    - TAS Reactome:R-HSA-9665699
    - TAS Reactome:R-HSA-9665700
    - TAS Reactome:R-HSA-9665701
    - TAS Reactome:R-HSA-9665704
    - TAS Reactome:R-HSA-9665705
    - TAS Reactome:R-HSA-9665706
    - TAS Reactome:R-HSA-9665707
    - TAS Reactome:R-HSA-9665709
    - TAS Reactome:R-HSA-9796044
    - TAS Reactome:R-NUL-1248744
    - TAS Reactome:R-NUL-1251923
    - TAS Reactome:R-NUL-1251929
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS PMID:3491360
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030669 clathrin-coated endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
  - term: GO:0031093 platelet alpha granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:21082674
- organism: human
  gene: EGF
  row_index: 222
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular exosome is retained as a non-core proteomics-supported location and does not supersede extracellular
    region or plasma membrane as the main EGF localizations.
  uniprot_subcellular_location: Membrane; Single-pass type I membrane protein.
  uniprot_function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some
    fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted
    tubule via engagement of EGFR and activation of the magnesium channel TRPM6 ...
  uniprot_features: *id077
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id078
- organism: human
  gene: EIF3E
  row_index: 50
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal localization is not a core function. Many cytoplasmic proteins are found in exosomes.
  uniprot_subcellular_location: Cytoplasm. Nucleus, PML body.
  uniprot_function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several
    steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates
    with the 40S ribosome and facilitates the recruitment of eIF-1, eI ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000785 chromatin
    qualifier: located_in
    evidence:
    - NAS PMID:17468741
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:10504338
    - IEA GO_REF:0000104
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - NAS PMID:17468741
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:10504338
    - IEA GO_REF:0000120
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-156808
    - TAS Reactome:R-HSA-156823
    - TAS Reactome:R-HSA-157849
    - TAS Reactome:R-HSA-72619
    - TAS Reactome:R-HSA-72621
    - TAS Reactome:R-HSA-72676
    - TAS Reactome:R-HSA-72691
    - TAS Reactome:R-HSA-72697
  - term: GO:0005852 eukaryotic translation initiation factor 3 complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:17322308
    - IDA PMID:17581632
    - IDA PMID:18599441
    - IDA PMID:25849773
    - IDA PMID:9295280
    - IEA GO_REF:0000120
    - IPI PMID:17322308
    - NAS PMID:10504338
  - term: GO:0014069 postsynaptic density
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016282 eukaryotic 43S preinitiation complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000104
  - term: GO:0016605 PML body
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:10504338
  - term: GO:0016605 PML body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0033290 eukaryotic 48S preinitiation complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000104
  - term: GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000104
- organism: human
  gene: FAH
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: FAH was cataloged among ~900 proteins in a shotgun proteomic survey of urinary exosomes. This is a bulk
    proteomics detection rather than a functional localization; FAH is fundamentally a cytosolic liver/kidney enzyme. The
    annotation is retained as a non-core secondary location observation.
  uniprot_subcellular_location: ''
  uniprot_function: ''
  uniprot_features: &id079 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id080
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-71181
- organism: human
  gene: FAH
  row_index: 12
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: FAH was among 1132 proteins identified in a large-scale proteomic profile of human urinary exosomes. As
    with PMID:23533145, this is a proteomic catalog detection, not a functional site of action; kept as non-core relative
    to the core cytosolic localization.
  uniprot_subcellular_location: ''
  uniprot_function: ''
  uniprot_features: *id079
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id080
- organism: human
  gene: FAS
  row_index: 64
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal localization may reflect secretion of soluble FAS isoforms or membrane FAS in exosomes. Not a core
    localization.
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000269|PubMed:1713127, ECO:0000269|PubMed:25301068}; Single-pass
    type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:25301068}. [Isoform 2]: Secreted. [Isoform 3]:
    Secreted. [Isoform 4]: Secreted. [Isoform 5]: Secreted. [Isoform 6]: Secreted.'
  uniprot_function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor.
    The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent
    cascade of caspases (aspartate-specific cysteine proteases) mediating apop ...
  uniprot_features:
  - LIPID
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - NAS PMID:7533181
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - IMP PMID:21625644
    - TAS Reactome:R-HSA-139952
    - TAS Reactome:R-HSA-141310
    - TAS Reactome:R-HSA-3465429
    - TAS Reactome:R-HSA-3465448
    - TAS Reactome:R-HSA-3465459
    - TAS Reactome:R-HSA-5675456
    - TAS Reactome:R-HSA-6800001
    - TAS Reactome:R-HSA-71050
    - TAS Reactome:R-HSA-73945
    - TAS Reactome:R-HSA-75244
    - TAS Reactome:R-HSA-83586
    - TAS Reactome:R-HSA-83650
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:22891283
    - IEA GO_REF:0000117
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0031264 death-inducing signaling complex
    qualifier: part_of
    evidence:
    - IDA PMID:11101870
    - IDA PMID:21803845
  - term: GO:0031265 CD95 death-inducing signaling complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:20935634
    - IEA GO_REF:0000117
  - term: GO:0045121 membrane raft
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:21382479
    - IEA GO_REF:0000044
- organism: human
  gene: FKBP4
  row_index: 55
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A high-throughput proteomic detection in exosomes; plausible passive presence but peripheral to the gene's
    core cytosolic function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:2378870}. Mitochondrion {ECO:0000269|PubMed:21730050}.
    Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon
    {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid
    receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
    {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}.
  uniprot_function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes
    through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric
    forms of steroid hormone receptors between cytoplasm and nuclear c ...
  uniprot_features: &id081 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id082
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5324617
    - TAS Reactome:R-HSA-5618080
    - TAS Reactome:R-HSA-5618093
    - TAS Reactome:R-HSA-9038161
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:2378870
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - EXP PMID:21730050
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-5618073
    - TAS Reactome:R-HSA-5618080
    - TAS Reactome:R-HSA-5618085
    - TAS Reactome:R-HSA-5618099
    - TAS Reactome:R-HSA-5618110
    - TAS Reactome:R-HSA-9678925
    - TAS Reactome:R-HSA-9690534
    - TAS Reactome:R-HSA-9705925
    - TAS Reactome:R-HSA-9705926
    - TAS Reactome:R-HSA-9706837
    - TAS Reactome:R-HSA-9725855
    - TAS Reactome:R-HSA-9725885
    - TAS Reactome:R-HSA-9726509
    - TAS Reactome:R-HSA-9726580
    - TAS Reactome:R-HSA-9726621
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0044295 axonal growth cone
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
- organism: human
  gene: FKBP4
  row_index: 56
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A high-throughput proteomic detection in exosomes; peripheral to the gene's core function.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:2378870}. Mitochondrion {ECO:0000269|PubMed:21730050}.
    Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon
    {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid
    receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
    {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}.
  uniprot_function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes
    through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric
    forms of steroid hormone receptors between cytoplasm and nuclear c ...
  uniprot_features: *id081
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id082
- organism: human
  gene: FKBP5
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A high-throughput proteomic detection; peripheral to the gene's core cytoplasmic function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}.
  uniprot_function: Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated
    steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular
    trafficking of heterooligomeric forms of steroid hormone receptors mainta ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IC PMID:28147277
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5618073
    - TAS Reactome:R-HSA-5618098
    - TAS Reactome:R-HSA-5618105
    - TAS Reactome:R-HSA-9909510
    - TAS Reactome:R-HSA-9909519
- organism: human
  gene: FN1
  row_index: 174
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Multiple proteomic studies (PMID:23533145, PMID:21276792, PMID:19056867) detect fibronectin in exosomes.
    While valid, exosomes represent a minor and specialized localization compared to ECM and extracellular space. This is
    peripheral to core fibronectin biology. Mark as non-core.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:29100092}. Secreted
    {ECO:0000250|UniProtKB:P11276}.
  uniprot_function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin
    (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility,
    opsonization, wound healing, and maintenance of cell shape (PubMed:30 ...
  uniprot_features: &id083
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id084
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-1566981
    - TAS Reactome:R-HSA-202723
    - TAS Reactome:R-HSA-216050
    - TAS Reactome:R-HSA-2327733
    - TAS Reactome:R-HSA-2327746
    - TAS Reactome:R-HSA-2396337
    - TAS Reactome:R-HSA-2533950
    - TAS Reactome:R-HSA-2537665
    - TAS Reactome:R-HSA-2545196
    - TAS Reactome:R-HSA-2681681
    - TAS Reactome:R-HSA-2731141
    - TAS Reactome:R-HSA-349593
    - TAS Reactome:R-HSA-354066
    - TAS Reactome:R-HSA-354073
    - TAS Reactome:R-HSA-354087
    - TAS Reactome:R-HSA-354124
    - TAS Reactome:R-HSA-354149
    - TAS Reactome:R-HSA-354165
    - TAS Reactome:R-HSA-372693
    - TAS Reactome:R-HSA-372697
    - TAS Reactome:R-HSA-372705
    - TAS Reactome:R-HSA-377640
    - TAS Reactome:R-HSA-377641
    - TAS Reactome:R-HSA-377643
    - TAS Reactome:R-HSA-377644
    - TAS Reactome:R-HSA-3785684
    - TAS Reactome:R-HSA-3788061
    - TAS Reactome:R-HSA-429415
    - TAS Reactome:R-HSA-429441
    - TAS Reactome:R-HSA-481007
    - TAS Reactome:R-HSA-6785895
    - TAS Reactome:R-HSA-9624017
    - TAS Reactome:R-HSA-9638552
    - TAS Reactome:R-HSA-9865226
    - TAS Reactome:R-HSA-9932034
  - term: GO:0005577 fibrinogen complex
    qualifier: part_of
    evidence:
    - IDA PMID:3997886
    - IPI PMID:20541508
  - term: GO:0005604 basement membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005615 extracellular space
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - IDA PMID:15292204
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8952289
  - term: GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
    qualifier: located_in
    evidence:
    - IDA PMID:15308636
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9700131
    - TAS Reactome:R-HSA-9700179
    - TAS Reactome:R-HSA-9700181
    - TAS Reactome:R-HSA-9700190
    - TAS Reactome:R-HSA-9700193
    - TAS Reactome:R-HSA-9712078
    - TAS Reactome:R-HSA-9712079
    - TAS Reactome:R-HSA-9712083
    - TAS Reactome:R-HSA-9712084
    - TAS Reactome:R-HSA-9712085
    - TAS Reactome:R-HSA-9724099
    - TAS Reactome:R-HSA-9850958
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031012 extracellular matrix
    qualifier: colocalizes_with
    evidence:
    - ISS PMID:22261194
  - term: GO:0031012 extracellular matrix
    qualifier: is_active_in
    evidence:
    - IDA PMID:26571399
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IDA PMID:16157329
    - IDA PMID:1632457
    - IDA PMID:26571399
    - IEA GO_REF:0000107
  - term: GO:0031093 platelet alpha granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:21276792
- organism: human
  gene: FN1
  row_index: 178
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic analysis (PMID:22516433) detects fibronectin in blood microparticles. While valid, this represents
    a minor and specialized localization. Plasma fibronectin is the relevant pool, microparticles are peripheral. Mark as
    non-core.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:29100092}. Secreted
    {ECO:0000250|UniProtKB:P11276}.
  uniprot_function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin
    (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility,
    opsonization, wound healing, and maintenance of cell shape (PubMed:30 ...
  uniprot_features: *id083
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id084
- organism: human
  gene: FN1
  row_index: 179
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Multiple proteomic studies (PMID:23533145, PMID:21276792, PMID:19056867) detect fibronectin in exosomes.
    While valid, exosomes represent a minor and specialized localization compared to ECM and extracellular space. This is
    peripheral to core fibronectin biology. Mark as non-core.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:29100092}. Secreted
    {ECO:0000250|UniProtKB:P11276}.
  uniprot_function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin
    (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility,
    opsonization, wound healing, and maintenance of cell shape (PubMed:30 ...
  uniprot_features: *id083
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id084
- organism: human
  gene: FTH1
  row_index: 45
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal secretion of ferritin has been documented and may contribute to serum ferritin levels and intercellular
    iron transfer. This is peripheral to the core intracellular iron storage function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:26436293}. Lysosome {ECO:0000269|PubMed:26436293}. Cytoplasmic
    vesicle, autophagosome {ECO:0000269|PubMed:24695223}.
  uniprot_function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase
    activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196).
    Also plays a role in delivery of iron to cells (By similar ...
  uniprot_features: &id085 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id086
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005776 autophagosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-1562626
    - TAS Reactome:R-HSA-434362
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000043
  - term: GO:0044754 autolysosome
    qualifier: located_in
    evidence:
    - IDA PMID:25327288
  - term: GO:0070288 ferritin complex
    qualifier: part_of
    evidence:
    - TAS PMID:6589621
  - term: GO:1904724 tertiary granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: FTH1
  row_index: 47
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Redundant with other exosome annotation. Exosomal secretion is peripheral to core function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:26436293}. Lysosome {ECO:0000269|PubMed:26436293}. Cytoplasmic
    vesicle, autophagosome {ECO:0000269|PubMed:24695223}.
  uniprot_function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase
    activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196).
    Also plays a role in delivery of iron to cells (By similar ...
  uniprot_features: *id085
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id086
- organism: human
  gene: G6PD
  row_index: 36
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput mass-spec localization to exosomes; likely reflects passive incorporation of an abundant
    cytosolic protein rather than a functional site.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:743300}. Membrane; Peripheral
    membrane protein {ECO:0000269|PubMed:743300}.
  uniprot_function: Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route
    for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power
    (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Al ...
  uniprot_features: &id087 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id088
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000054
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:35122041
    - IDA PMID:743300
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-70377
    - TAS Reactome:R-HSA-9761849
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:743300
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: G6PD
  row_index: 39
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput exosome proteomics; incidental localization of an abundant cytosolic protein, not a functional
    site.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:743300}. Membrane; Peripheral
    membrane protein {ECO:0000269|PubMed:743300}.
  uniprot_function: Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route
    for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power
    (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Al ...
  uniprot_features: *id087
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id088
- organism: human
  gene: GALK1
  row_index: 17
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: GALK1 was detected among many proteins in a large-scale urinary exosome proteomic survey. Many abundant
    cytosolic proteins are recovered in exosome preparations; this does not reflect the site of catalytic function. Retained
    as non-core rather than removed, as it is a valid detection record.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the transfer of a phosphate from ATP to alpha-D- galactose and participates in the first committed
    step in the catabolism of galactose. {ECO:0000269|PubMed:12694189, ECO:0000269|PubMed:7542884}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:8908517
    - IEA GO_REF:0000002
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5610026
    - TAS Reactome:R-HSA-70355
  - term: GO:0016020 membrane
    qualifier: NOT|located_in
    evidence:
    - IDA PMID:8908517
- organism: human
  gene: GALM
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Reflects broad proteomic detection in secreted exosomes rather than the enzyme's site of catalytic function,
    which is the cytosol. Kept as a non-core localization; not part of the core Leloir-pathway function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000305}.
  uniprot_function: 'Mutarotase that catalyzes the interconversion of beta-D- galactose and alpha-D-galactose during galactose
    metabolism (PubMed:12753898). Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic
    fuel, by the action of four enzymes that constitute the Leloir pathway: ...'
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9931853
    - TAS Reactome:R-HSA-9931926
- organism: human
  gene: GALNS
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: GALNS was among ~900 proteins detected by shotgun proteomics of prostatic-secretion exosomes. This supports
    extracellular-exosome localisation but is peripheral to the enzyme's lysosomal core role.
  uniprot_subcellular_location: Lysosome {ECO:0000269|PubMed:30760748}.
  uniprot_function: Lysosomal enzyme that hydrolyzes sulfate groups from glycosaminoglycans (GAGs), keratan sulfate (KS) and
    chondroitin-6- sulfate (C6S). {ECO:0000269|PubMed:820716}.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:30760748
    - IEA GO_REF:0000120
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1630304
    - TAS Reactome:R-HSA-2263490
- organism: human
  gene: GAS6
  row_index: 39
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: extracellular exosome is plausible but secondary to the conserved GAS6 ligand/adaptor role.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:9326369}.
  uniprot_function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell
    growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial
    cell survival during acidification by preventing apoptosis, optimal cy ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-202710
    - TAS Reactome:R-HSA-481007
  - term: GO:0005615 extracellular space
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - IDA PMID:18395422
    - IDA PMID:19922767
    - IDA PMID:20088931
    - IDA PMID:8336730
    - IEA GO_REF:0000120
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:18395422
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-163809
    - TAS Reactome:R-HSA-8952289
  - term: GO:0005796 Golgi lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-163809
    - TAS Reactome:R-HSA-163843
  - term: GO:0031093 platelet alpha granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481007
- organism: human
  gene: GBA
  row_index: 81
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A high-throughput mass-spectrometry detection in a secreted/exosomal proteome; consistent with the known
    partial secretion of GCase, but not its site of function. Retain as non-core.
  uniprot_subcellular_location: Lysosome membrane {ECO:0000269|PubMed:17187079, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18022370};
    Peripheral membrane protein {ECO:0000269|PubMed:10781797, ECO:0000269|PubMed:18022370, ECO:0000269|PubMed:1848227}; Lumenal
    side {ECO:0000269|PubMed:18022370}. Note=Interaction with saposin-C promotes membrane association (PubMed:10781797). Targeting
    to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2 (PubMed:18022370). {ECO:0000269|PubMed:10781797,
    ECO:0000269|PubMed:18022370}.
  uniprot_function: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers
    (such as beta- D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose
    (PubMed:15916907, PubMed:24211208, PubMed:32144204, PubMed:39395789 ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - IMP PMID:25202012
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17187079
    - IEA GO_REF:0000120
    - IPI PMID:40159502
    - ISS PMID:18022370
    - TAS Reactome:R-HSA-1605591
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005802 trans-Golgi network
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS PMID:18022370
- organism: human
  gene: GBA1
  row_index: 83
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain as non-core high-throughput localization context while keeping lysosome/lysosomal membrane as the
    core location.
  uniprot_subcellular_location: Lysosome membrane {ECO:0000269|PubMed:17187079, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18022370};
    Peripheral membrane protein {ECO:0000269|PubMed:10781797, ECO:0000269|PubMed:18022370, ECO:0000269|PubMed:1848227}; Lumenal
    side {ECO:0000269|PubMed:18022370}. Note=Interaction with saposin-C promotes membrane association (PubMed:10781797). Targeting
    to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2 (PubMed:18022370). {ECO:0000269|PubMed:10781797,
    ECO:0000269|PubMed:18022370}.
  uniprot_function: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers
    (such as beta- D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose
    (PubMed:15916907, PubMed:24211208, PubMed:32144204, PubMed:39395789 ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - IMP PMID:25202012
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17187079
    - IEA GO_REF:0000120
    - IPI PMID:40159502
    - ISS PMID:18022370
    - TAS Reactome:R-HSA-1605591
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005802 trans-Golgi network
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS PMID:18022370
- organism: human
  gene: GET3
  row_index: 35
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic catalog localization; not part of GET3's core cytosolic targeting function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9736449}.
    Endoplasmic reticulum {ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:31461301}. Nucleus,
    nucleolus {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9736449}.
  uniprot_function: ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic
    reticulum (PubMed:17382883). Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
    This complex then targets to the endoplasmic reticulum by membrane-bound recept ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005730 nucleolus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS PMID:9736449
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:17382883
    - EXP PMID:21444755
    - IEA GO_REF:0000044
    - TAS PMID:9736449
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - EXP PMID:17382883
    - EXP PMID:21444755
    - EXP PMID:31461301
    - IEA GO_REF:0000120
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32910895
  - term: GO:0043529 GET complex
    qualifier: part_of
    evidence:
    - IDA PMID:32910895
    - IEA GO_REF:0000120
    - IPI PMID:23041287
    - IPI PMID:32910895
- organism: human
  gene: GFPT1
  row_index: 23
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate
    from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:32019926, PubMed:35229715).
    Inhibited by UDP-N-acetylglucosamine (UDP-G ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1791088
    - TAS Reactome:R-HSA-4085027
    - TAS Reactome:R-HSA-449715
- organism: human
  gene: GGT1
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection in a secreted-vesicle preparation; incidental localization, not the
    core plasma-membrane site of action. Non-core.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}; Single-pass type
    II membrane protein {ECO:0000250|UniProtKB:P07314}.
  uniprot_function: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates
    (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)- docosahexaenoate, MCTR1) and other
    gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:17924658,  ...
  uniprot_features: &id089
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id090
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:8095045
    - IDA PMID:23682772
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-266046
    - TAS Reactome:R-HSA-5433072
    - TAS Reactome:R-HSA-5602984
    - TAS Reactome:R-HSA-8943279
    - TAS Reactome:R-HSA-9035966
    - TAS Reactome:R-HSA-9753634
- organism: human
  gene: GGT1
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection in exosomes; incidental localization. Non-core.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}; Single-pass type
    II membrane protein {ECO:0000250|UniProtKB:P07314}.
  uniprot_function: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates
    (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)- docosahexaenoate, MCTR1) and other
    gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:17924658,  ...
  uniprot_features: *id089
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id090
- organism: human
  gene: GLA
  row_index: 21
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome proteomics can capture secreted lysosomal enzymes, but it does not define the core compartment where
    GLA acts.
  uniprot_subcellular_location: Lysosome.
  uniprot_function: Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
    {ECO:0000269|PubMed:10838196, ECO:0000269|PubMed:8804427}.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:3029062
    - IEA GO_REF:0000117
    - IMP PMID:1332979
    - TAS Reactome:R-HSA-6798751
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IMP PMID:1332979
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - IMP PMID:1332979
    - TAS PMID:3029062
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IMP PMID:1332979
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1605736
    - TAS Reactome:R-HSA-9841189
- organism: human
  gene: GLB1
  row_index: 40
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: GLB1 is detected in extracellular exosomes by mass spectrometry, consistent with its presence in secretory/extracellular
    fluids, but this is not its physiological site of action. Valid non-core location from a large-scale proteomics survey.
  uniprot_subcellular_location: '[Isoform 1]: Lysosome {ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:3084261}. [Isoform
    2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:2511208}. Note=Localized to the perinuclear area of the cytoplasm
    but not to lysosomes. {ECO:0000269|PubMed:2511208}.'
  uniprot_function: '[Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
    {ECO:0000269|PubMed:15714521, ECO:0000269|PubMed:19472408, ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:25936995, ECO:0000269|PubMed:8200356}.
    [Isoform 2]: Has no beta-galactosid ...'
  uniprot_features: &id091
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id092
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:11927518
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IMP PMID:8112731
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - EXP PMID:2511208
    - EXP PMID:3084261
    - IEA GO_REF:0000120
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1605624
    - TAS Reactome:R-HSA-1605724
    - TAS Reactome:R-HSA-1606312
    - TAS Reactome:R-HSA-1630306
    - TAS Reactome:R-HSA-2090079
    - TAS Reactome:R-HSA-2265534
    - TAS Reactome:R-HSA-4084999
    - TAS Reactome:R-HSA-4341669
    - TAS Reactome:R-HSA-9036061
    - TAS Reactome:R-HSA-9638120
    - TAS Reactome:R-HSA-9840795
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: GLB1
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: GLB1 was identified in the urinary-exosome proteome by LC-MS/MS. A valid non-core extracellular-vesicle
    location, not the enzyme's site of action.
  uniprot_subcellular_location: '[Isoform 1]: Lysosome {ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:3084261}. [Isoform
    2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:2511208}. Note=Localized to the perinuclear area of the cytoplasm
    but not to lysosomes. {ECO:0000269|PubMed:2511208}.'
  uniprot_function: '[Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
    {ECO:0000269|PubMed:15714521, ECO:0000269|PubMed:19472408, ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:25936995, ECO:0000269|PubMed:8200356}.
    [Isoform 2]: Has no beta-galactosid ...'
  uniprot_features: *id091
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id092
- organism: human
  gene: GLIPR2
  row_index: 5
  term: GO:0070062 extracellular exosome
  reference: PMID:18570454
  reference_title: Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow
    liquid chromatography-tandem mass spectrometry.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA dataset supports occasional extracellular-vesicle cargo, but the cached abstract does not expose
    the GLIPR2 peptide row. This context-specific proteomic localization does not define the cytosolic Golgi protein's core
    site of activity.
  uniprot_subcellular_location: Golgi apparatus membrane {ECO:0000269|PubMed:11865038}; Lipid-anchor {ECO:0000269|PubMed:11865038}.
    Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.
  uniprot_function: ''
  uniprot_features: &id093
  - LIPID
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id094
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IDA PMID:11865038
    - IEA GO_REF:0000044
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
- organism: human
  gene: GLIPR2
  row_index: 6
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The full paper establishes a large exosome proteome, while the protein-level GLIPR2 row resides in supplementary
    data not represented in the cached article. The HDA localization is retained as vesicle-cargo context, not as evidence
    for extracellular function.
  uniprot_subcellular_location: Golgi apparatus membrane {ECO:0000269|PubMed:11865038}; Lipid-anchor {ECO:0000269|PubMed:11865038}.
    Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.
  uniprot_function: ''
  uniprot_features: *id093
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id094
- organism: human
  gene: GLIPR2
  row_index: 12
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The curated HDA finding is compatible with vesicular export from renal epithelia, but the cached main article
    does not enumerate the GLIPR2 peptide row. It is retained as a context-specific cargo localization, not a core extracellular
    site of action.
  uniprot_subcellular_location: Golgi apparatus membrane {ECO:0000269|PubMed:11865038}; Lipid-anchor {ECO:0000269|PubMed:11865038}.
    Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.
  uniprot_function: ''
  uniprot_features: *id093
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id094
- organism: human
  gene: GLO1
  row_index: 15
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The high-throughput cargo observation is retained, but detection among roughly 900 proteins does not establish
    active secretion or an extracellular GLO1 pathway.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione
    (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity
    of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis ...
  uniprot_features: &id095 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id096
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - TAS PMID:16130169
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:20454679
    - TAS Reactome:R-HSA-5694071
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
- organism: human
  gene: GLO1
  row_index: 19
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection among 1,132 proteins is a valid proteomic cargo observation but does not demonstrate that exosomal
    GLO1 is catalytically active or normally secreted. It is retained outside the cytosolic core.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione
    (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity
    of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis ...
  uniprot_features: *id095
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id096
- organism: human
  gene: GLOD4
  row_index: 3
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The detection is real, but abundant cytosolic proteins are routinely recovered in exosome proteomes and
    this compartment is not where the enzyme acts. Retained as a peripheral location rather than discarded.
  uniprot_subcellular_location: Mitochondrion {ECO:0000305|PubMed:12897971}.
  uniprot_function: ''
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: GM2A
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosome proteomes documents a secreted pool; exosomes derive from the endolysosomal/multivesicular-body
    system, so GM2A presence is plausible, but this is a localization observation rather than a functional site. Non-core.
  uniprot_subcellular_location: Lysosome {ECO:0000305|PubMed:8900233}.
  uniprot_function: Lipid-binding and transfer protein essential for lysosomal degradation of ganglioside GM2. Extracts single
    GM2 molecules from intralysosomal luminal vesicle (ILV) membranes and presents them in soluble form to beta-hexosaminidase
    A (HEXA) for cleavage of N-acetyl- D-galactosamine and conversion to G ...
  uniprot_features: &id097
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id098
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016323 basolateral plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1605595
    - TAS Reactome:R-HSA-1605624
    - TAS Reactome:R-HSA-1605717
    - TAS Reactome:R-HSA-9840795
    - TAS Reactome:R-HSA-9840833
    - TAS Reactome:R-HSA-9840884
  - term: GO:0160317 endolysosomal intralumenal vesicle membrane
    qualifier: is_active_in
    evidence:
    - IC PMID:11707436
    - IC PMID:27498570
- organism: human
  gene: GM2A
  row_index: 29
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Large-scale urinary-exosome proteomics detected GM2A; documents a secreted pool consistent with the endolysosomal
    origin of exosomes, but not the functional site. Non-core.
  uniprot_subcellular_location: Lysosome {ECO:0000305|PubMed:8900233}.
  uniprot_function: Lipid-binding and transfer protein essential for lysosomal degradation of ganglioside GM2. Extracts single
    GM2 molecules from intralysosomal luminal vesicle (ILV) membranes and presents them in soluble form to beta-hexosaminidase
    A (HEXA) for cleavage of N-acetyl- D-galactosamine and conversion to G ...
  uniprot_features: *id097
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id098
- organism: human
  gene: GNS
  row_index: 21
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Large-scale proteomic detection in an exosome preparation; consistent with GNS being a soluble, secretable
    hydrolase but not indicative of its core catabolic site.
  uniprot_subcellular_location: Lysosome.
  uniprot_function: Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate.
    {ECO:0000269|PubMed:1463457}.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0042582 azurophil granule
    qualifier: located_in
    evidence:
    - IDA PMID:15595925
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1638032
    - TAS Reactome:R-HSA-2263495
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: GOT1
  row_index: 39
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary/incidental localization from exosome proteomics; the functional site is the cytosol.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:1974457}.
  uniprot_function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels
    of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
    in brain neuroprotection. The aspartate aminotransferase activity ...
  uniprot_features: &id099 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id100
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:7060339
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-70581
    - TAS Reactome:R-HSA-70592
  - term: GO:0043679 axon terminus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: GOT1
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary exosomal localization; not core to GOT1 function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:1974457}.
  uniprot_function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels
    of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
    in brain neuroprotection. The aspartate aminotransferase activity ...
  uniprot_features: *id099
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id100
- organism: human
  gene: GOT1
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary exosomal localization; not core to GOT1 function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:1974457}.
  uniprot_function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels
    of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
    in brain neuroprotection. The aspartate aminotransferase activity ...
  uniprot_features: *id099
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id100
- organism: human
  gene: GOT1
  row_index: 43
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary exosomal localization; not core to GOT1 function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:1974457}.
  uniprot_function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels
    of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
    in brain neuroprotection. The aspartate aminotransferase activity ...
  uniprot_features: *id099
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id100
- organism: human
  gene: GOT2
  row_index: 19
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary/incidental localization from exosome proteomics; the functional site is the mitochondrial matrix
    (with a moonlighting plasma-membrane pool).
  uniprot_subcellular_location: Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}.
    Note=Exposure to alcohol promotes translocation to the cell membrane. {ECO:0000269|PubMed:9537447}.
  uniprot_function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic
    acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is
    important for metabolite exchange between mitochondria and cytosol, and for  ...
  uniprot_features: &id101 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id102
  - term: GO:0005739 mitochondrion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA PMID:9537447
    - ISS GO_REF:0000024
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-6784393
    - TAS Reactome:R-HSA-70596
    - TAS Reactome:R-HSA-70613
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:9537447
    - IEA GO_REF:0000044
- organism: human
  gene: GOT2
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary exosomal localization; not core to GOT2 function.
  uniprot_subcellular_location: Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}.
    Note=Exposure to alcohol promotes translocation to the cell membrane. {ECO:0000269|PubMed:9537447}.
  uniprot_function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic
    acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is
    important for metabolite exchange between mitochondria and cytosol, and for  ...
  uniprot_features: *id101
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id102
- organism: human
  gene: GPI
  row_index: 49
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with the secreted/extracellular moonlighting pool detected in a large-scale exosome proteomic
    survey; peripheral to the core function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
  uniprot_function: Isomerase that catalyzes the conversion of alpha-D-glucose-6- phosphate to beta-D-fructose-6-phosphate,
    the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). Also
    shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) an ...
  uniprot_features: &id103 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id104
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:11437381
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:11437381
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-70471
    - TAS Reactome:R-HSA-70475
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0060170 ciliary membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: GPI
  row_index: 51
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with the secreted/extracellular moonlighting pool detected in a large-scale exosome proteomic
    survey; peripheral to the core function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
  uniprot_function: Isomerase that catalyzes the conversion of alpha-D-glucose-6- phosphate to beta-D-fructose-6-phosphate,
    the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). Also
    shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) an ...
  uniprot_features: *id103
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id104
- organism: human
  gene: GPI
  row_index: 52
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with the secreted/extracellular moonlighting pool detected in a large-scale exosome proteomic
    survey; peripheral to the core function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
  uniprot_function: Isomerase that catalyzes the conversion of alpha-D-glucose-6- phosphate to beta-D-fructose-6-phosphate,
    the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). Also
    shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) an ...
  uniprot_features: *id103
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id104
- organism: human
  gene: GPI
  row_index: 53
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with the secreted/extracellular moonlighting pool detected in a large-scale exosome proteomic
    survey; peripheral to the core function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
  uniprot_function: Isomerase that catalyzes the conversion of alpha-D-glucose-6- phosphate to beta-D-fructose-6-phosphate,
    the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). Also
    shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) an ...
  uniprot_features: *id103
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id104
- organism: human
  gene: GRB2
  row_index: 943
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection in exosomes; not a functional site for GRB2's adaptor activity. Retained
    as non-core.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:37328606}. Cytoplasm {ECO:0000269|PubMed:21179510,
    ECO:0000269|PubMed:30282717, ECO:0000269|PubMed:37328606}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}.
  uniprot_function: Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from
    cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11016927, PubMed:11726515,
    PubMed:37626338). Thus, participates in many biological process ...
  uniprot_features: &id105 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id106
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:37328606
    - IDA PMID:21179510
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:30282717
    - EXP PMID:37328606
    - IDA PMID:21179510
    - IEA GO_REF:0000120
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:21179510
    - IEA GO_REF:0000044
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000117
    - TAS PMID:14722116
    - TAS Reactome:R-HSA-109699
    - TAS Reactome:R-HSA-109813
    - TAS Reactome:R-HSA-109822
    - TAS Reactome:R-HSA-109823
    - TAS Reactome:R-HSA-1225950
    - TAS Reactome:R-HSA-1225951
    - TAS Reactome:R-HSA-1225957
    - TAS Reactome:R-HSA-1225961
    - TAS Reactome:R-HSA-1226012
    - TAS Reactome:R-HSA-1226014
    - TAS Reactome:R-HSA-1226016
    - TAS Reactome:R-HSA-1250380
    - TAS Reactome:R-HSA-1250383
    - TAS Reactome:R-HSA-1295613
    - TAS Reactome:R-HSA-1306957
    - TAS Reactome:R-HSA-1306963
    - TAS Reactome:R-HSA-1306965
    - TAS Reactome:R-HSA-1306969
    - TAS Reactome:R-HSA-1306972
    - TAS Reactome:R-HSA-1433428
    - TAS Reactome:R-HSA-1433454
    - TAS Reactome:R-HSA-1433471
    - TAS Reactome:R-HSA-1433514
    - TAS Reactome:R-HSA-1549564
    - TAS Reactome:R-HSA-1562641
    - TAS Reactome:R-HSA-177920
    - TAS Reactome:R-HSA-177923
    - TAS Reactome:R-HSA-177924
    - TAS Reactome:R-HSA-177926
    - TAS Reactome:R-HSA-177927
    - TAS Reactome:R-HSA-177930
    - TAS Reactome:R-HSA-177931
    - TAS Reactome:R-HSA-177935
    - TAS Reactome:R-HSA-177936
    - TAS Reactome:R-HSA-177938
    - TAS Reactome:R-HSA-177939
    - TAS Reactome:R-HSA-177941
    - TAS Reactome:R-HSA-177943
    - TAS Reactome:R-HSA-177944
    - TAS Reactome:R-HSA-177945
    - TAS Reactome:R-HSA-179467
    - TAS Reactome:R-HSA-182994
    - TAS Reactome:R-HSA-183002
    - TAS Reactome:R-HSA-183036
    - TAS Reactome:R-HSA-183052
    - TAS Reactome:R-HSA-183058
    - TAS Reactome:R-HSA-183067
    - TAS Reactome:R-HSA-183084
    - TAS Reactome:R-HSA-1839095
    - TAS Reactome:R-HSA-1839102
    - TAS Reactome:R-HSA-1839107
    - TAS Reactome:R-HSA-1839110
    - TAS Reactome:R-HSA-1839114
    - TAS Reactome:R-HSA-186826
    - TAS Reactome:R-HSA-186834
    - TAS Reactome:R-HSA-2029466
    - TAS Reactome:R-HSA-204871
    - TAS Reactome:R-HSA-205234
    - TAS Reactome:R-HSA-205244
    - TAS Reactome:R-HSA-205286
    - TAS Reactome:R-HSA-210974
    - TAS Reactome:R-HSA-210977
    - TAS Reactome:R-HSA-2179407
    - TAS Reactome:R-HSA-2179415
    - TAS Reactome:R-HSA-2197690
    - TAS Reactome:R-HSA-2197691
    - TAS Reactome:R-HSA-2197698
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2396561
    - TAS Reactome:R-HSA-2396594
    - TAS Reactome:R-HSA-2396599
    - TAS Reactome:R-HSA-2396606
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-2424476
    - TAS Reactome:R-HSA-2424477
    - TAS Reactome:R-HSA-2424481
    - TAS Reactome:R-HSA-2424484
    - TAS Reactome:R-HSA-2424485
    - TAS Reactome:R-HSA-2424486
    - TAS Reactome:R-HSA-2424487
    - TAS Reactome:R-HSA-2730833
    - TAS Reactome:R-HSA-2730837
    - TAS Reactome:R-HSA-2730840
    - TAS Reactome:R-HSA-2730841
    - TAS Reactome:R-HSA-2730842
    - TAS Reactome:R-HSA-2730844
    - TAS Reactome:R-HSA-2730847
    - TAS Reactome:R-HSA-2730851
    - TAS Reactome:R-HSA-2730856
    - TAS Reactome:R-HSA-2730858
    - TAS Reactome:R-HSA-2730870
    - TAS Reactome:R-HSA-2730889
    - TAS Reactome:R-HSA-2730892
    - TAS Reactome:R-HSA-354087
    - TAS Reactome:R-HSA-354165
    - TAS Reactome:R-HSA-388814
    - TAS Reactome:R-HSA-389348
    - TAS Reactome:R-HSA-389350
    - TAS Reactome:R-HSA-389352
    - TAS Reactome:R-HSA-389354
    - TAS Reactome:R-HSA-389919
    - TAS Reactome:R-HSA-391153
    - TAS Reactome:R-HSA-392051
    - TAS Reactome:R-HSA-392053
    - TAS Reactome:R-HSA-392054
    - TAS Reactome:R-HSA-453104
    - TAS Reactome:R-HSA-453111
    - TAS Reactome:R-HSA-508247
    - TAS Reactome:R-HSA-5637764
    - TAS Reactome:R-HSA-5637765
    - TAS Reactome:R-HSA-5637770
    - TAS Reactome:R-HSA-5637798
    - TAS Reactome:R-HSA-5637801
    - TAS Reactome:R-HSA-5637806
    - TAS Reactome:R-HSA-5637808
    - TAS Reactome:R-HSA-5654392
    - TAS Reactome:R-HSA-5654402
    - TAS Reactome:R-HSA-5654406
    - TAS Reactome:R-HSA-5654413
    - TAS Reactome:R-HSA-5654416
    - TAS Reactome:R-HSA-5654423
    - TAS Reactome:R-HSA-5654426
    - TAS Reactome:R-HSA-5654586
    - TAS Reactome:R-HSA-5654591
    - TAS Reactome:R-HSA-5654592
    - TAS Reactome:R-HSA-5654594
    - TAS Reactome:R-HSA-5654596
    - TAS Reactome:R-HSA-5654597
    - TAS Reactome:R-HSA-5654600
    - TAS Reactome:R-HSA-5654612
    - TAS Reactome:R-HSA-5654614
    - TAS Reactome:R-HSA-5654615
    - TAS Reactome:R-HSA-5654618
    - TAS Reactome:R-HSA-5654620
    - TAS Reactome:R-HSA-5654622
    - TAS Reactome:R-HSA-5654637
    - TAS Reactome:R-HSA-5654640
    - TAS Reactome:R-HSA-5654641
    - TAS Reactome:R-HSA-5654643
    - TAS Reactome:R-HSA-5654646
    - TAS Reactome:R-HSA-5654647
    - TAS Reactome:R-HSA-5654659
    - TAS Reactome:R-HSA-5654662
    - TAS Reactome:R-HSA-5654663
    - TAS Reactome:R-HSA-5654664
    - TAS Reactome:R-HSA-5654667
    - TAS Reactome:R-HSA-5654669
    - TAS Reactome:R-HSA-5654672
    - TAS Reactome:R-HSA-5654673
    - TAS Reactome:R-HSA-5654677
    - TAS Reactome:R-HSA-5654679
    - TAS Reactome:R-HSA-5654684
    - TAS Reactome:R-HSA-5654690
    - TAS Reactome:R-HSA-5654692
    - TAS Reactome:R-HSA-5654697
    - TAS Reactome:R-HSA-5654701
    - TAS Reactome:R-HSA-5654705
    - TAS Reactome:R-HSA-5654709
    - TAS Reactome:R-HSA-5654714
    - TAS Reactome:R-HSA-5654717
    - TAS Reactome:R-HSA-5654729
    - TAS Reactome:R-HSA-5654730
    - TAS Reactome:R-HSA-5654734
    - TAS Reactome:R-HSA-5655233
    - TAS Reactome:R-HSA-5655235
    - TAS Reactome:R-HSA-5655240
    - TAS Reactome:R-HSA-5655241
    - TAS Reactome:R-HSA-5655245
    - TAS Reactome:R-HSA-5655248
    - TAS Reactome:R-HSA-5655252
    - TAS Reactome:R-HSA-5655263
    - TAS Reactome:R-HSA-5655266
    - TAS Reactome:R-HSA-5655277
    - TAS Reactome:R-HSA-5655285
    - TAS Reactome:R-HSA-5655289
    - TAS Reactome:R-HSA-5655290
    - TAS Reactome:R-HSA-5655295
    - TAS Reactome:R-HSA-5655315
    - TAS Reactome:R-HSA-5655320
    - TAS Reactome:R-HSA-5655323
    - TAS Reactome:R-HSA-5655326
    - TAS Reactome:R-HSA-5655347
    - TAS Reactome:R-HSA-5655348
    - TAS Reactome:R-HSA-5672965
    - TAS Reactome:R-HSA-5685366
    - TAS Reactome:R-HSA-5686073
    - TAS Reactome:R-HSA-5686074
    - TAS Reactome:R-HSA-5686315
    - TAS Reactome:R-HSA-74736
    - TAS Reactome:R-HSA-74746
    - TAS Reactome:R-HSA-879917
    - TAS Reactome:R-HSA-8851804
    - TAS Reactome:R-HSA-8851827
    - TAS Reactome:R-HSA-8851899
    - TAS Reactome:R-HSA-8851900
    - TAS Reactome:R-HSA-8851919
    - TAS Reactome:R-HSA-8851933
    - TAS Reactome:R-HSA-8851954
    - TAS Reactome:R-HSA-8852019
    - TAS Reactome:R-HSA-8853734
    - TAS Reactome:R-HSA-8853774
    - TAS Reactome:R-HSA-8853793
    - TAS Reactome:R-HSA-8854897
    - TAS Reactome:R-HSA-8854899
    - TAS Reactome:R-HSA-8854905
    - TAS Reactome:R-HSA-8855508
    - TAS Reactome:R-HSA-8865994
    - TAS Reactome:R-HSA-8866279
    - TAS Reactome:R-HSA-8867041
    - TAS Reactome:R-HSA-8867044
    - TAS Reactome:R-HSA-8867047
    - TAS Reactome:R-HSA-8867754
    - TAS Reactome:R-HSA-8867756
    - TAS Reactome:R-HSA-8868071
    - TAS Reactome:R-HSA-8868072
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
    - TAS Reactome:R-HSA-8874685
    - TAS Reactome:R-HSA-8875183
    - TAS Reactome:R-HSA-8875451
    - TAS Reactome:R-HSA-8875482
    - TAS Reactome:R-HSA-8875490
    - TAS Reactome:R-HSA-8875540
    - TAS Reactome:R-HSA-8875558
    - TAS Reactome:R-HSA-8875568
    - TAS Reactome:R-HSA-8875576
    - TAS Reactome:R-HSA-8875591
    - TAS Reactome:R-HSA-8875659
    - TAS Reactome:R-HSA-8875661
    - TAS Reactome:R-HSA-8876240
    - TAS Reactome:R-HSA-8876258
    - TAS Reactome:R-HSA-8951490
    - TAS Reactome:R-HSA-8983384
    - TAS Reactome:R-HSA-9018766
    - TAS Reactome:R-HSA-9029150
    - TAS Reactome:R-HSA-9032073
    - TAS Reactome:R-HSA-912527
    - TAS Reactome:R-HSA-912627
    - TAS Reactome:R-HSA-913424
    - TAS Reactome:R-HSA-9606887
    - TAS Reactome:R-HSA-9607301
    - TAS Reactome:R-HSA-9607304
    - TAS Reactome:R-HSA-9634402
    - TAS Reactome:R-HSA-9634418
    - TAS Reactome:R-HSA-9664918
    - TAS Reactome:R-HSA-9664933
    - TAS Reactome:R-HSA-9664940
    - TAS Reactome:R-HSA-9664983
    - TAS Reactome:R-HSA-9664991
    - TAS Reactome:R-HSA-9665000
    - TAS Reactome:R-HSA-9665009
    - TAS Reactome:R-HSA-9665404
    - TAS Reactome:R-HSA-9665407
    - TAS Reactome:R-HSA-9665408
    - TAS Reactome:R-HSA-9665409
    - TAS Reactome:R-HSA-9665413
    - TAS Reactome:R-HSA-9665415
    - TAS Reactome:R-HSA-9665417
    - TAS Reactome:R-HSA-9665698
    - TAS Reactome:R-HSA-9665699
    - TAS Reactome:R-HSA-9665700
    - TAS Reactome:R-HSA-9665707
    - TAS Reactome:R-HSA-9670428
    - TAS Reactome:R-HSA-9670436
    - TAS Reactome:R-HSA-9672158
    - TAS Reactome:R-HSA-9672163
    - TAS Reactome:R-HSA-9672164
    - TAS Reactome:R-HSA-9672170
    - TAS Reactome:R-HSA-9674816
    - TAS Reactome:R-HSA-9695841
    - TAS Reactome:R-HSA-9695845
    - TAS Reactome:R-HSA-9695853
    - TAS Reactome:R-HSA-9698000
    - TAS Reactome:R-HSA-9698003
    - TAS Reactome:R-HSA-9698005
    - TAS Reactome:R-HSA-9698007
    - TAS Reactome:R-HSA-9698008
    - TAS Reactome:R-HSA-9698013
    - TAS Reactome:R-HSA-9698029
    - TAS Reactome:R-HSA-9698170
    - TAS Reactome:R-HSA-9698174
    - TAS Reactome:R-HSA-9703430
    - TAS Reactome:R-HSA-9703434
    - TAS Reactome:R-HSA-9703438
    - TAS Reactome:R-HSA-9703441
    - TAS Reactome:R-HSA-9710914
    - TAS Reactome:R-HSA-9724099
    - TAS Reactome:R-HSA-983703
    - TAS Reactome:R-HSA-9842655
    - TAS Reactome:R-HSA-9842665
    - TAS Reactome:R-HSA-9842669
    - TAS Reactome:R-NUL-1250468
    - TAS Reactome:R-NUL-1250472
    - TAS Reactome:R-NUL-1250475
    - TAS Reactome:R-NUL-1250500
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-1112666
    - TAS Reactome:R-HSA-2076220
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-9606151
    - TAS Reactome:R-HSA-9606887
    - TAS Reactome:R-HSA-9691421
    - TAS Reactome:R-HSA-983703
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005938 cell cortex
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0008180 COP9 signalosome
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:22561606
    - IEA GO_REF:0000107
  - term: GO:0012506 vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0070436 Grb2-EGFR complex
    qualifier: part_of
    evidence:
    - IDA PMID:20086093
- organism: human
  gene: GRB2
  row_index: 944
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection; non-core location.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:37328606}. Cytoplasm {ECO:0000269|PubMed:21179510,
    ECO:0000269|PubMed:30282717, ECO:0000269|PubMed:37328606}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}.
  uniprot_function: Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from
    cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11016927, PubMed:11726515,
    PubMed:37626338). Thus, participates in many biological process ...
  uniprot_features: *id105
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id106
- organism: human
  gene: GRB2
  row_index: 945
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection; non-core location.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:37328606}. Cytoplasm {ECO:0000269|PubMed:21179510,
    ECO:0000269|PubMed:30282717, ECO:0000269|PubMed:37328606}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}.
  uniprot_function: Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from
    cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11016927, PubMed:11726515,
    PubMed:37626338). Thus, participates in many biological process ...
  uniprot_features: *id105
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id106
- organism: human
  gene: GSR
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: '[Isoform Mitochondrial]: Mitochondrion. [Isoform Cytoplasmic]: Cytoplasm.'
  uniprot_function: Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the
    major mechanism to maintain a high GSH:GSSG ratio in the cytosol. {ECO:0000269|PubMed:17185460}.
  uniprot_features: &id107 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id108
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005739 mitochondrion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-3323079
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-71682
    - TAS Reactome:R-HSA-9761843
- organism: human
  gene: GSR
  row_index: 23
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: '[Isoform Mitochondrial]: Mitochondrion. [Isoform Cytoplasmic]: Cytoplasm.'
  uniprot_function: Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the
    major mechanism to maintain a high GSH:GSSG ratio in the cytosol. {ECO:0000269|PubMed:17185460}.
  uniprot_features: *id107
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id108
- organism: human
  gene: GSS
  row_index: 15
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes represents a secondary localization rather than the primary functional compartment.
    Many cytosolic proteins are found in exosomes as part of general cellular content packaging. This does not reflect the
    core function or localization of GSS.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the production of glutathione from gamma- glutamylcysteine and glycine in an ATP-dependent manner
    (PubMed:7646467, PubMed:9215686). Glutathione (gamma- glutamylcysteinylglycine, GSH) is the most abundant intracellular
    thiol in living aerobic cells and is required for numerous processes inc ...
  uniprot_features: &id109 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id110
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-174394
    - TAS Reactome:R-HSA-5602901
- organism: human
  gene: GSS
  row_index: 17
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Duplicate annotation with different evidence source. Detection in exosomes is a secondary localization not
    reflecting the primary functional site.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the production of glutathione from gamma- glutamylcysteine and glycine in an ATP-dependent manner
    (PubMed:7646467, PubMed:9215686). Glutathione (gamma- glutamylcysteinylglycine, GSH) is the most abundant intracellular
    thiol in living aerobic cells and is required for numerous processes inc ...
  uniprot_features: *id109
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id110
- organism: human
  gene: GUSB
  row_index: 24
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal detection is a peripheral localisation typical of many lysosomal/secreted proteins; not the core
    site of action.
  uniprot_subcellular_location: Lysosome.
  uniprot_function: Plays an important role in the degradation of dermatan and keratan sulfates.
  uniprot_features: &id111
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id112
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:25645918
    - TAS Reactome:R-HSA-6798751
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1678854
    - TAS Reactome:R-HSA-2162226
    - TAS Reactome:R-HSA-2162227
    - TAS Reactome:R-HSA-2318373
    - TAS Reactome:R-HSA-9036068
    - TAS Reactome:R-HSA-9036070
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: GUSB
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal detection; peripheral localisation, not the core site of action.
  uniprot_subcellular_location: Lysosome.
  uniprot_function: Plays an important role in the degradation of dermatan and keratan sulfates.
  uniprot_features: *id111
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id112
- organism: human
  gene: HEXA
  row_index: 46
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic detection in exosomes; a non-core, incidental extracellular location for a lysosomal enzyme.
  uniprot_subcellular_location: Lysosome {ECO:0000305|PubMed:16698036}.
  uniprot_function: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates,
    such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436,
    PubMed:16698036, PubMed:8123671, PubMed:8672428, PubMed:96 ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:33966596
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0036021 endolysosome lumen
    qualifier: is_active_in
    evidence:
    - IC PMID:11707436
    - IC PMID:27498570
  - term: GO:0042582 azurophil granule
    qualifier: located_in
    evidence:
    - IDA PMID:25645918
    - IEA GO_REF:0000117
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - NAS PMID:6458607
    - TAS Reactome:R-HSA-1605595
    - TAS Reactome:R-HSA-1605632
    - TAS Reactome:R-HSA-1638053
    - TAS Reactome:R-HSA-2105001
    - TAS Reactome:R-HSA-2162225
    - TAS Reactome:R-HSA-9035976
    - TAS Reactome:R-HSA-9840833
    - TAS Reactome:R-HSA-9840884
  - term: GO:1905379 beta-N-acetylhexosaminidase complex
    qualifier: part_of
    evidence:
    - IDA PMID:11707436
    - IPI PMID:16698036
- organism: human
  gene: HGD
  row_index: 10
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection in exosome fractions is common for abundant cytosolic proteins and does
    not establish a functional site of action. Retained as a recorded observation but explicitly non-core; the functional
    localization is cytosol.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the conversion of homogentisate to maleylacetoacetate. {ECO:0000269|PubMed:8782815}.
  uniprot_features: &id113 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id114
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-71164
- organism: human
  gene: HGD
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Bystander detection in an exosome proteome, not a functional localization; retained as non-core.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the conversion of homogentisate to maleylacetoacetate. {ECO:0000269|PubMed:8782815}.
  uniprot_features: *id113
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id114
- organism: human
  gene: HPD
  row_index: 27
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HPD was identified in a large-scale urinary exosome/phosphoproteome screen. Such high-throughput proteomic
    localizations are frequently incidental and do not reflect the functional cytosolic site of the enzyme; retained as non-core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:41317403}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32755};
    Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P32755}; Peripheral
    membrane protein {ECO:0000250|UniProtKB:P32755}. Nucleus {ECO:0000269|PubMed:41317403}.
  uniprot_function: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine
    catabolism (PubMed:10942115, PubMed:1339442, PubMed:34047349, PubMed:37794595). In addition may act as a N6-methyltransferase
    that methylates adenosine residues at the N(6) position of some RNA ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:41317403
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:41317403
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-71163
- organism: human
  gene: HPRT1
  row_index: 34
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HPRT1 is a soluble cytosolic salvage enzyme; its presence in the exosome proteome is a common finding for
    abundant cytosolic proteins and does not represent its functional localization. Retained as a non-core localization.
  uniprot_subcellular_location: Cytoplasm.
  uniprot_function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the
    5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of
    purine nucleotides through the purine salvage pathway.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:6300847
    - IEA GO_REF:0000120
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-74215
    - TAS Reactome:R-HSA-9734274
    - TAS Reactome:R-HSA-9748951
- organism: human
  gene: HPX
  row_index: 17
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics detection in exosomes is valid but represents minor localization compared to plasma. Not a core
    localization.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin
    returns to the circulation.
  uniprot_features: &id115
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id116
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-2168884
    - TAS Reactome:R-HSA-2168886
    - TAS Reactome:R-HSA-2168887
    - TAS Reactome:R-HSA-2168897
    - TAS Reactome:R-HSA-2230983
  - term: GO:0005615 extracellular space
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - IDA PMID:19433579
    - TAS PMID:3855550
  - term: GO:0071682 endocytic vesicle lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-2230983
- organism: human
  gene: HPX
  row_index: 19
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in blood microparticles is valid but represents minor localization. HPX's primary function is
    as soluble plasma protein.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin
    returns to the circulation.
  uniprot_features: *id115
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id116
- organism: human
  gene: HPX
  row_index: 20
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization, not core function site.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin
    returns to the circulation.
  uniprot_features: *id115
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id116
- organism: human
  gene: HSPA12A
  row_index: 9
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This supports context-specific extracellular-vesicle association at the proteomics level, but it does not
    establish exosome biology as a core or proteostasis-defining function for HSPA12A.
  uniprot_subcellular_location: Cytoplasm {ECO:0000250|UniProtKB:Q8K0U4}. Nucleus {ECO:0000250|UniProtKB:Q8K0U4}.
  uniprot_function: Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization.
    {ECO:0000269|PubMed:30679749}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
- organism: human
  gene: HSPA13
  row_index: 18
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Mass-spectrometry detection in exosomes records a real pool but is peripheral to STCH's ER/microsomal quality-control
    function.
  uniprot_subcellular_location: Microsome. Endoplasmic reticulum.
  uniprot_function: Has peptide-independent ATPase activity.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043231 intracellular membrane-bounded organelle
    qualifier: located_in
    evidence:
    - TAS PMID:8131751
- organism: human
  gene: HSPA1B
  row_index: 82
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. Vesicle localization is a secondary feature, not core localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome {ECO:0000269|PubMed:27137183}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: &id117 []
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: &id118
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:10205060
    - IDA PMID:17167422
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-3371467
    - TAS Reactome:R-HSA-3371518
    - TAS Reactome:R-HSA-3371554
    - TAS Reactome:R-HSA-5082356
    - TAS Reactome:R-HSA-5082369
    - TAS Reactome:R-HSA-5082384
    - TAS Reactome:R-HSA-5251955
    - TAS Reactome:R-HSA-5252041
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:10859165
    - IDA PMID:24061851
    - IDA PMID:24790089
    - IDA PMID:9553041
    - IEA GO_REF:0000044
    - TAS PMID:16130169
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - TAS PMID:16130169
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - TAS PMID:16130169
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA PMID:27137183
    - IEA GO_REF:0000044
  - term: GO:0005814 centriole
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:24061851
    - IEA GO_REF:0000117
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:21231916
    - TAS Reactome:R-HSA-3371422
    - TAS Reactome:R-HSA-3371503
    - TAS Reactome:R-HSA-3371590
    - TAS Reactome:R-HSA-5251942
    - TAS Reactome:R-HSA-5251959
    - TAS Reactome:R-HSA-5252041
    - TAS Reactome:R-HSA-5252079
    - TAS Reactome:R-HSA-5618085
    - TAS Reactome:R-HSA-5618098
    - TAS Reactome:R-HSA-5618105
    - TAS Reactome:R-HSA-5618107
    - TAS Reactome:R-HSA-5618110
    - TAS Reactome:R-HSA-9835411
    - TAS Reactome:R-HSA-9857076
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016234 inclusion body
    qualifier: located_in
    evidence:
    - IDA PMID:15603737
  - term: GO:0016235 aggresome
    qualifier: located_in
    evidence:
    - IDA PMID:15885686
    - IEA GO_REF:0000117
  - term: GO:0016607 nuclear speck
    qualifier: located_in
    evidence:
    - IDA PMID:9553041
    - IEA GO_REF:0000117
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:23349634
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:10205060
    - IDA PMID:15603737
    - IEA GO_REF:0000117
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-6800434
  - term: GO:1990904 ribonucleoprotein complex
    qualifier: part_of
    evidence:
    - IDA PMID:17289661
    - IEA GO_REF:0000117
- organism: human
  gene: HSPA1B
  row_index: 86
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. Exosomal localization of HSP70 is well-documented but represents a non-core
    secondary localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome {ECO:0000269|PubMed:27137183}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: *id117
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id118
- organism: human
  gene: HSPA1B
  row_index: 87
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. Exosomal localization is a secondary, non-core feature of HSPA1B.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome {ECO:0000269|PubMed:27137183}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: *id117
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id118
- organism: human
  gene: HSPA1B
  row_index: 88
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. Exosomal localization is non-core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome {ECO:0000269|PubMed:27137183}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: *id117
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id118
- organism: human
  gene: HSPA1B
  row_index: 141
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. Blood microparticle localization is a secondary, non-core feature consistent
    with extracellular HSP70 release.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome {ECO:0000269|PubMed:27137183}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: *id117
  gene_vesicle_rows: 5
  gene_vesicle_references: 5
  leads: *id118
- organism: human
  gene: HSPA1L
  row_index: 28
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in blood microparticles is from a high-throughput proteomics study and likely reflects general
    HSP70 family presence in extracellular vesicles rather than a specific function of HSPA1L. The study noted "remarkably
    high variability in the protein content of plasma from different donors" (PMID:22516433), suggesting this may not be a
    consistent localization. Not a core localization for HSPA1L function.
  uniprot_subcellular_location: ''
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0002199 zona pellucida receptor complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5082356
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21231916
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0008180 COP9 signalosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:18850735
  - term: GO:0044297 cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: HSPA2
  row_index: 48
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in blood microparticles is a common finding for abundant intracellular proteins in proteomics
    studies. This is not a core functional localization for HSPA2 but may reflect real biology (extracellular chaperone function
    or vesicular secretion).
  uniprot_subcellular_location: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P17156}. Note=Colocalizes with SHCBP1L
    at spindle during the meiosis process. {ECO:0000250|UniProtKB:P17156}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: &id119 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id120
  - term: GO:0000795 synaptonemal complex
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0001673 male germ cell nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21231916
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0036128 CatSper complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0072687 meiotic spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
- organism: human
  gene: HSPA2
  row_index: 49
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HSP70 family members are commonly detected in exosome proteomics. While potentially real, extracellular
    exosome localization is not a core functional localization for HSPA2, whose primary functions are in cytosolic protein
    folding and meiotic spermatocyte biology.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P17156}. Note=Colocalizes with SHCBP1L
    at spindle during the meiosis process. {ECO:0000250|UniProtKB:P17156}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: *id119
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id120
- organism: human
  gene: HSPA4
  row_index: 25
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The reported broad organelle/vesicle association does not establish the principal function of HSPA4. Retain
    the location as a contextual observation while using cytosolic chaperone regulation as the core biological description.
  uniprot_subcellular_location: Cytoplasm {ECO:0000305}.
  uniprot_function: ''
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21231916
  - term: GO:0043226 organelle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:21276792
- organism: human
  gene: HSPA6
  row_index: 34
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection of HSPA6 in blood microparticles by HDA proteomics (PMID:22516433) is plausible given that HSP70
    proteins are commonly found in extracellular vesicles. However, this is not a core localization for HSPA6. The annotation
    is retained as non-core. Note that HSP70 proteins are common contaminants in proteomic studies.
  uniprot_subcellular_location: ''
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: &id121 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id122
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:24061851
  - term: GO:0005814 centriole
    qualifier: located_in
    evidence:
    - IDA PMID:24061851
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21231916
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0008180 COP9 signalosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:18850735
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: HSPA6
  row_index: 35
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HSPA6 detection in exosomes (PMID:19199708) is plausible but raises questions given that HSPA6 has no basal
    expression (PMID:2327978). This may reflect cross-identification with other HSP70 family members given high sequence similarity,
    or the cells may have been under stress. HSP70 family members are common exosome cargo. Retained as non-core since extracellular
    exosome is not a core localization for HSPA6.
  uniprot_subcellular_location: ''
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins
    and the formation and dissociation of protein complexes. Plays a pivotal  ...
  uniprot_features: *id121
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id122
- organism: human
  gene: HSPA8
  row_index: 169
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. HSPA8 is one of the most frequently identified exosomal proteins.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus,
    nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane
    protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP
    granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially
    to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis
    of misfolded proteins, formation and dissociation of protein comp ...
  uniprot_features: &id123 []
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: &id124
  - term: GO:0000974 Prp19 complex
    qualifier: part_of
    evidence:
    - IDA PMID:20176811
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:20176811
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-3371467
    - TAS Reactome:R-HSA-3371518
    - TAS Reactome:R-HSA-3371554
    - TAS Reactome:R-HSA-5082356
    - TAS Reactome:R-HSA-5082369
    - TAS Reactome:R-HSA-5082384
    - TAS Reactome:R-HSA-8932221
    - TAS Reactome:R-HSA-9770131
    - TAS Reactome:R-HSA-9770141
    - TAS Reactome:R-HSA-9770145
    - TAS Reactome:R-HSA-9770236
    - TAS Reactome:R-HSA-9770847
    - TAS Reactome:R-HSA-9772351
    - TAS Reactome:R-HSA-9794542
  - term: GO:0005681 spliceosomal complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000043
  - term: GO:0005730 nucleolus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:17289661
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005765 lysosomal membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:11559757
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21231916
    - TAS Reactome:R-HSA-3371422
    - TAS Reactome:R-HSA-3371503
    - TAS Reactome:R-HSA-3371590
    - TAS Reactome:R-HSA-421836
    - TAS Reactome:R-HSA-432688
    - TAS Reactome:R-HSA-450551
    - TAS Reactome:R-HSA-450580
    - TAS Reactome:R-HSA-5618085
    - TAS Reactome:R-HSA-5618098
    - TAS Reactome:R-HSA-5618105
    - TAS Reactome:R-HSA-5618107
    - TAS Reactome:R-HSA-5618110
    - TAS Reactome:R-HSA-6797269
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-9835411
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-888589
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS PMID:25719862
  - term: GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-888589
    - TAS Reactome:R-HSA-917744
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:19028452
    - IDA PMID:21235781
  - term: GO:0098575 lumenal side of lysosomal membrane
    qualifier: located_in
    evidence:
    - TAS PMID:20176123
  - term: GO:0101031 protein folding chaperone complex
    qualifier: part_of
    evidence:
    - IDA PMID:25719862
    - IPI PMID:16207813
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-6800434
  - term: GO:1990904 ribonucleoprotein complex
    qualifier: part_of
    evidence:
    - IDA PMID:17289661
    - IEA GO_REF:0000117
- organism: human
  gene: HSPA8
  row_index: 184
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization reflecting HSPA8's presence in extracellular particles.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus,
    nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane
    protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP
    granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially
    to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis
    of misfolded proteins, formation and dissociation of protein comp ...
  uniprot_features: *id123
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id124
- organism: human
  gene: HSPA8
  row_index: 198
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. HSPA8 is one of the most frequently identified exosomal proteins.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus,
    nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane
    protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP
    granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially
    to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis
    of misfolded proteins, formation and dissociation of protein comp ...
  uniprot_features: *id123
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id124
- organism: human
  gene: HSPA8
  row_index: 199
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. HSPA8 is one of the most frequently identified exosomal proteins.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus,
    nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane
    protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP
    granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially
    to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis
    of misfolded proteins, formation and dissociation of protein comp ...
  uniprot_features: *id123
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id124
- organism: human
  gene: HSPA8
  row_index: 201
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. HSPA8 is one of the most frequently identified exosomal proteins.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus,
    nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane
    protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP
    granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially
    to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis
    of misfolded proteins, formation and dissociation of protein comp ...
  uniprot_features: *id123
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id124
- organism: human
  gene: HSPA8
  row_index: 221
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. HSPA8 is one of the most frequently identified exosomal proteins.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17289661}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus,
    nucleolus {ECO:0000269|PubMed:1586970}. Cell membrane. Lysosome membrane {ECO:0000269|PubMed:11559757}; Peripheral membrane
    protein {ECO:0000269|PubMed:11559757}; Cytoplasmic side {ECO:0000269|PubMed:11559757}. Note=Localized in cytoplasmic mRNP
    granules containing untranslated mRNAs (PubMed:17289661). Translocates rapidly from the cytoplasm to the nuclei, and especially
    to the nucleoli, upon heat shock (PubMed:1586970). {ECO:0000269|PubMed:1586970, ECO:0000269|PubMed:17289661}.
  uniprot_function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome
    from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis
    of misfolded proteins, formation and dissociation of protein comp ...
  uniprot_features: *id123
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id124
- organism: human
  gene: HSPA9
  row_index: 72
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal/extracellular mortalin is documented and biologically relevant in some contexts (e.g., cancer signaling),
    but it is non-core relative to HSPA9's mitochondrial matrix function. Keep as non-core.
  uniprot_subcellular_location: Mitochondrion {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:26702583}. Nucleus, nucleolus
    {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:24625977}. Cytoplasm {ECO:0000269|PubMed:24625977}. Mitochondrion matrix
    {ECO:0000250|UniProtKB:P48721}. Note=Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria
    contact sites. {ECO:0000250|UniProtKB:P48721}.
  uniprot_function: Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly.
    Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded
    proteins, and the targeting of proteins for subsequent degradation. These  ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005730 nucleolus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS PMID:7684501
  - term: GO:0005739 mitochondrion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:26702583
    - IDA PMID:7896880
    - IEA GO_REF:0000120
    - TAS PMID:16130169
    - TAS PMID:7829505
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - NAS PMID:10339406
  - term: GO:0005759 mitochondrial matrix
    qualifier: is_active_in
    evidence:
    - IDA PMID:7865888
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-8950389
    - TAS Reactome:R-HSA-9838035
    - TAS Reactome:R-HSA-9838081
    - TAS Reactome:R-HSA-9838093
    - TAS Reactome:R-HSA-9838289
    - TAS Reactome:R-HSA-9856627
  - term: GO:0042645 mitochondrial nucleoid
    qualifier: located_in
    evidence:
    - IDA PMID:18063578
- organism: human
  gene: HSPD1
  row_index: 168
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Hsp60 can be detected outside its principal matrix pool, including stress-associated cytosolic, membrane
    and extracellular fractions. The curated observation is retained without inferring that Hsp60 is a constitutive secreted
    signal or a structural component of every detected vesicle. Physiological interpretation remains context-dependent.
  uniprot_subcellular_location: Mitochondrion matrix.
  uniprot_function: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10,
    facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper
    assembly of unfolded polypeptides generated under stress conditions in the mi ...
  uniprot_features: &id125 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id126
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:18229457
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:21328542
    - IEA GO_REF:0000107
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:17823127
    - IDA PMID:18086682
    - IDA PMID:21245038
    - IEA GO_REF:0000107
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0005759 mitochondrial matrix
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:7865888
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IDA PMID:15784682
    - IDA PMID:19393246
    - IDA PMID:24746669
    - IEA GO_REF:0000044
    - TAS PMID:17823127
    - TAS Reactome:R-HSA-8869558
    - TAS Reactome:R-HSA-9838035
    - TAS Reactome:R-HSA-9838081
    - TAS Reactome:R-HSA-9838093
    - TAS Reactome:R-HSA-9838289
    - TAS Reactome:R-HSA-9856666
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IDA PMID:11807771
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:17823127
    - IDA PMID:18086682
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:11027668
    - IEA GO_REF:0000107
  - term: GO:0005905 clathrin-coated pit
    qualifier: located_in
    evidence:
    - IDA PMID:11807771
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:10663613
    - IDA PMID:11807771
    - IDA PMID:15784682
    - IDA PMID:9243807
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030135 coated vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:11807771
  - term: GO:0030141 secretory granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:21328542
    - IDA PMID:23349634
  - term: GO:0046696 lipopolysaccharide receptor complex
    qualifier: part_of
    evidence:
    - IDA PMID:17164250
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:21276792
  - term: GO:0097225 sperm midpiece
    qualifier: located_in
    evidence:
    - IMP PMID:32791035
  - term: GO:0140494 migrasome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: HSPD1
  row_index: 169
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Hsp60 can be detected outside its principal matrix pool, including stress-associated cytosolic, membrane
    and extracellular fractions. The curated observation is retained without inferring that Hsp60 is a constitutive secreted
    signal or a structural component of every detected vesicle. Physiological interpretation remains context-dependent.
  uniprot_subcellular_location: Mitochondrion matrix.
  uniprot_function: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10,
    facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper
    assembly of unfolded polypeptides generated under stress conditions in the mi ...
  uniprot_features: *id125
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id126
- organism: human
  gene: HSPG2
  row_index: 55
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. Detection of perlecan in exosome preparations likely reflects extracellular contamination
    or non-specific association rather than a functional role in exosome biology. Perlecan is a massive secreted ECM protein
    not expected to be packaged into exosomes. This annotation does not represent a core function or localization.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted {ECO:0000269|PubMed:25326458,
    ECO:0000269|PubMed:36213313}.
  uniprot_function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible
    for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
    It serves as an attachment substrate for cells. Plays essential role ...
  uniprot_features: &id127
  - SIGNAL
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id128
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-1592314
    - TAS Reactome:R-HSA-2396337
    - TAS Reactome:R-HSA-2396395
    - TAS Reactome:R-HSA-2534240
    - TAS Reactome:R-HSA-3814820
    - TAS Reactome:R-HSA-4084505
    - TAS Reactome:R-HSA-4088220
    - TAS Reactome:R-HSA-4088281
    - TAS Reactome:R-HSA-976734
    - TAS Reactome:R-HSA-9914537
    - TAS Reactome:R-NUL-2534170
  - term: GO:0005604 basement membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS PMID:21126803
    - TAS PMID:8621634
  - term: GO:0005796 Golgi lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-1667005
    - TAS Reactome:R-HSA-1878002
    - TAS Reactome:R-HSA-1889955
    - TAS Reactome:R-HSA-1889978
    - TAS Reactome:R-HSA-1889981
    - TAS Reactome:R-HSA-2022851
    - TAS Reactome:R-HSA-2022856
    - TAS Reactome:R-HSA-2022860
    - TAS Reactome:R-HSA-2022887
    - TAS Reactome:R-HSA-2024108
    - TAS Reactome:R-HSA-2076383
    - TAS Reactome:R-HSA-2076392
    - TAS Reactome:R-HSA-2076419
    - TAS Reactome:R-HSA-2076508
    - TAS Reactome:R-HSA-2076611
    - TAS Reactome:R-HSA-3560802
    - TAS Reactome:R-HSA-3560804
    - TAS Reactome:R-HSA-3656254
    - TAS Reactome:R-HSA-3656257
    - TAS Reactome:R-HSA-3656261
    - TAS Reactome:R-HSA-3656267
    - TAS Reactome:R-HSA-4420365
    - TAS Reactome:R-HSA-9036285
    - TAS Reactome:R-HSA-9036289
    - TAS Reactome:R-HSA-9940993
    - TAS Reactome:R-HSA-9941039
    - TAS Reactome:R-HSA-9953259
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1678694
    - TAS Reactome:R-HSA-2024084
    - TAS Reactome:R-HSA-2024108
    - TAS Reactome:R-HSA-2404131
    - TAS Reactome:R-HSA-2423785
    - TAS Reactome:R-HSA-2429643
    - TAS Reactome:R-HSA-9694579
    - TAS Reactome:R-HSA-9694661
    - TAS Reactome:R-HSA-9698988
    - TAS Reactome:R-HSA-9699007
    - TAS Reactome:R-HSA-9836899
  - term: GO:0031012 extracellular matrix
    qualifier: colocalizes_with
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0031594 neuromuscular junction
    qualifier: is_active_in
    evidence:
    - IC PMID:14702351
  - term: GO:0043005 neuron projection
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1667005
    - TAS Reactome:R-HSA-2024084
  - term: GO:0098797 plasma membrane protein complex
    qualifier: part_of
    evidence:
    - TAS PMID:21289173
- organism: human
  gene: HSPG2
  row_index: 57
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. Similar to other exosome annotations, detection of this massive ECM protein in exosome
    preparations likely reflects contamination or non-specific association rather than true exosomal packaging. Not a functional
    or core localization for perlecan.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted {ECO:0000269|PubMed:25326458,
    ECO:0000269|PubMed:36213313}.
  uniprot_function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible
    for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
    It serves as an attachment substrate for cells. Plays essential role ...
  uniprot_features: *id127
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id128
- organism: human
  gene: HSPG2
  row_index: 58
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. Detection in exosome preparations does not represent a core function. Given perlecan's
    size (468 kDa) and role as an ECM structural protein, presence in exosomes likely reflects extracellular contamination
    rather than functional exosomal packaging.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted {ECO:0000269|PubMed:25326458,
    ECO:0000269|PubMed:36213313}.
  uniprot_function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible
    for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
    It serves as an attachment substrate for cells. Plays essential role ...
  uniprot_features: *id127
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id128
- organism: human
  gene: HSPG2
  row_index: 68
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Non-core localization. Similar to other exosome annotations, detection of this large ECM structural protein
    in exosome preparations likely reflects contamination. Not a functional localization.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted {ECO:0000269|PubMed:25326458,
    ECO:0000269|PubMed:36213313}.
  uniprot_function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible
    for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
    It serves as an attachment substrate for cells. Plays essential role ...
  uniprot_features: *id127
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id128
- organism: human
  gene: IDUA
  row_index: 21
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomics survey placed IDUA in urinary exosomes; lysosomal/secretory hydrolases are commonly recovered
    in extracellular vesicles. This is a valid detection but not the enzyme's primary functional location, so it is retained
    as non-core.
  uniprot_subcellular_location: Lysosome {ECO:0000305}.
  uniprot_function: Lysosomal hydrolase responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan
    sulfate. {ECO:0000269|PubMed:7998955}.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-1678716
    - TAS Reactome:R-HSA-1793186
    - TAS Reactome:R-HSA-2090037
    - TAS Reactome:R-HSA-2206299
    - TAS Reactome:R-HSA-9036037
    - TAS Reactome:R-HSA-9036041
- organism: human
  gene: ITGB1
  row_index: 321
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome proteomics (urine, prostatic secretion) detects beta1; membrane proteins are carried on exosomes.
    Non-core.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:32487760, ECO:0000269|PubMed:35687021,
    ECO:0000303|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane
    {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10455171,
    ECO:0000269|PubMed:11919189}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome {ECO:0000269|PubMed:16256741}.
    Melanosome {ECO:0000269|PubMed:17081065}. Cleavage furrow {ECO:0000269|PubMed:17956333}. Cell projecti ...
  uniprot_function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen.
    Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins
    alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha ...
  uniprot_features: &id129
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id130
  - term: GO:0001726 ruffle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS PMID:11919189
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16803572
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:17158881
    - EXP PMID:32487760
    - EXP PMID:35687021
    - IDA GO_REF:0000052
    - IDA PMID:12869515
    - IDA PMID:16803572
    - IDA PMID:21310825
    - IEA GO_REF:0000120
    - NAS PMID:10455171
    - TAS Reactome:R-HSA-198941
    - TAS Reactome:R-HSA-202706
    - TAS Reactome:R-HSA-202723
    - TAS Reactome:R-HSA-204434
    - TAS Reactome:R-HSA-216043
    - TAS Reactome:R-HSA-216045
    - TAS Reactome:R-HSA-216048
    - TAS Reactome:R-HSA-216050
    - TAS Reactome:R-HSA-216058
    - TAS Reactome:R-HSA-216064
    - TAS Reactome:R-HSA-216068
    - TAS Reactome:R-HSA-2327695
    - TAS Reactome:R-HSA-2327746
    - TAS Reactome:R-HSA-2328037
    - TAS Reactome:R-HSA-2395320
    - TAS Reactome:R-HSA-2396029
    - TAS Reactome:R-HSA-2426259
    - TAS Reactome:R-HSA-2426471
    - TAS Reactome:R-HSA-2484965
    - TAS Reactome:R-HSA-265424
    - TAS Reactome:R-HSA-265428
    - TAS Reactome:R-HSA-265429
    - TAS Reactome:R-HSA-2681667
    - TAS Reactome:R-HSA-2731074
    - TAS Reactome:R-HSA-349626
    - TAS Reactome:R-HSA-374686
    - TAS Reactome:R-HSA-3907292
    - TAS Reactome:R-HSA-4084903
    - TAS Reactome:R-HSA-4084912
    - TAS Reactome:R-HSA-4085083
    - TAS Reactome:R-HSA-4085133
    - TAS Reactome:R-HSA-4086132
    - TAS Reactome:R-HSA-4086216
    - TAS Reactome:R-HSA-4086223
    - TAS Reactome:R-HSA-4088220
    - TAS Reactome:R-HSA-4088264
    - TAS Reactome:R-HSA-432897
    - TAS Reactome:R-HSA-5666049
    - TAS Reactome:R-HSA-6788346
    - TAS Reactome:R-HSA-8875531
    - TAS Reactome:R-HSA-9609689
    - TAS Reactome:R-HSA-9610867
    - TAS Reactome:R-HSA-9611147
    - TAS Reactome:R-HSA-9611158
    - TAS Reactome:R-HSA-9624017
    - TAS Reactome:R-HSA-9679740
    - TAS Reactome:R-HSA-9865215
    - TAS Reactome:R-HSA-9865226
    - TAS Reactome:R-NUL-2473498
    - TAS Reactome:R-NUL-2545201
    - TAS Reactome:R-NUL-2752136
    - TAS Reactome:R-NUL-3907289
    - TAS Reactome:R-NUL-4084899
    - TAS Reactome:R-NUL-4084908
    - TAS Reactome:R-NUL-4084922
    - TAS Reactome:R-NUL-4085088
  - term: GO:0005925 focal adhesion
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:14970227
  - term: GO:0005925 focal adhesion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005925 focal adhesion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:12417594
    - IDA PMID:17158881
    - IDA PMID:23023225
    - IDA PMID:29162887
    - IEA GO_REF:0000044
  - term: GO:0008305 integrin complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IC PMID:10655584
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0009986 cell surface
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:17158881
    - IDA PMID:1715889
    - IDA PMID:19234460
    - IDA PMID:19933311
    - IDA PMID:20563599
    - IDA PMID:21310825
    - IDA PMID:23023225
    - IDA PMID:23154389
    - IDA PMID:23620790
    - IDA PMID:24036928
    - IDA PMID:25063885
    - IEA GO_REF:0000120
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9611147
  - term: GO:0014704 intercalated disc
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030175 filopodium
    qualifier: located_in
    evidence:
    - IDA PMID:16803572
    - IEA GO_REF:0000117
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: colocalizes_with
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031594 neuromuscular junction
    qualifier: located_in
    evidence:
    - IDA PMID:9415431
    - IEA GO_REF:0000107
  - term: GO:0032154 cleavage furrow
    qualifier: located_in
    evidence:
    - EXP PMID:17956333
    - IEA GO_REF:0000044
  - term: GO:0032587 ruffle membrane
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:14970227
  - term: GO:0032587 ruffle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:10455171
  - term: GO:0034665 integrin alpha1-beta1 complex
    qualifier: part_of
    evidence:
    - IDA PMID:24823363
    - NAS PMID:22451694
  - term: GO:0034666 integrin alpha2-beta1 complex
    qualifier: part_of
    evidence:
    - IDA PMID:24823363
    - IPI PMID:14681217
  - term: GO:0034667 integrin alpha3-beta1 complex
    qualifier: part_of
    evidence:
    - IDA PMID:24220332
    - IDA PMID:25063885
  - term: GO:0034668 integrin alpha4-beta1 complex
    qualifier: part_of
    evidence:
    - IPI PMID:1542691
    - TAS PMID:8020569
  - term: GO:0034674 integrin alpha5-beta1 complex
    qualifier: part_of
    evidence:
    - IDA PMID:31331973
    - IDA PMID:33102950
    - IPI PMID:22451694
  - term: GO:0034675 integrin alpha6-beta1 complex
    qualifier: part_of
    evidence:
    - IPI PMID:2649503
  - term: GO:0034677 integrin alpha7-beta1 complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0034678 integrin alpha8-beta1 complex
    qualifier: part_of
    evidence:
    - TAS PMID:21335239
  - term: GO:0034679 integrin alpha9-beta1 complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
    - IPI PMID:25748048
    - ISS GO_REF:0000024
  - term: GO:0034680 integrin alpha10-beta1 complex
    qualifier: part_of
    evidence:
    - IDA PMID:24823363
    - IPI PMID:9685391
  - term: GO:0034681 integrin alpha11-beta1 complex
    qualifier: part_of
    evidence:
    - IDA PMID:24823363
    - NAS PMID:19693543
  - term: GO:0034682 integrin alphav-beta1 complex
    qualifier: part_of
    evidence:
    - IPI PMID:25398877
  - term: GO:0035748 myelin sheath abaxonal region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0042383 sarcolemma
    qualifier: located_in
    evidence:
    - IDA PMID:9415431
    - IEA GO_REF:0000120
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - EXP PMID:17081065
    - IEA GO_REF:0000120
  - term: GO:0043197 dendritic spine
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043235 signaling receptor complex
    qualifier: part_of
    evidence:
    - IDA PMID:23382219
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:14559243
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045202 synapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: colocalizes_with
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:20183869
  - term: GO:0055037 recycling endosome
    qualifier: located_in
    evidence:
    - EXP PMID:16256741
    - IEA GO_REF:0000044
  - term: GO:0070161 anchoring junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0071133 alpha9-beta1 integrin-ADAM8 complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0097060 synaptic membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0097386 glial cell projection
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0098685 Schaffer collateral - CA1 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0150053 cerebellar climbing fiber to Purkinje cell synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: ITGB1
  row_index: 322
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome proteomics (urine, prostatic secretion) detects beta1; membrane proteins are carried on exosomes.
    Non-core.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:32487760, ECO:0000269|PubMed:35687021,
    ECO:0000303|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane
    {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10455171,
    ECO:0000269|PubMed:11919189}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome {ECO:0000269|PubMed:16256741}.
    Melanosome {ECO:0000269|PubMed:17081065}. Cleavage furrow {ECO:0000269|PubMed:17956333}. Cell projecti ...
  uniprot_function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen.
    Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins
    alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha ...
  uniprot_features: *id129
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id130
- organism: human
  gene: ITIH1
  row_index: 10
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA observation is retained, but ITIH1 is an abundant soluble plasma protein and could co-purify with
    extracellular vesicles. The study does not establish vesicle incorporation or an exosomal function.
  uniprot_subcellular_location: Secreted.
  uniprot_function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan
    which are essential to cells undergoing biological processes. Contains a  ...
  uniprot_features: &id131
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id132
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:14718574
- organism: human
  gene: ITIH1
  row_index: 11
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The source HDA observation is valid, but it does not distinguish stable microparticle association from adsorption
    or co-purification of an abundant plasma protein. This is not a defining functional location.
  uniprot_subcellular_location: Secreted.
  uniprot_function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan
    which are essential to cells undergoing biological processes. Contains a  ...
  uniprot_features: *id131
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id132
- organism: human
  gene: ITIH2
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ITIH2 is an abundant plasma protein, and its detection in exosome preparations may reflect plasma contamination
    rather than bona fide exosomal localization. Exosomes are secreted in biological fluids that also contain plasma proteins,
    making it difficult to distinguish true exosomal components from co-purifying plasma proteins in HDA studies. While ITIH2
    may be present in exosomal fractions, this does not represent a core functional localization. The primary and functionally
    relevant localization of ITIH2 is in plasma and the ECM where it stabilizes hyaluronan. This annotation should be kept
    but marked as non-core.
  uniprot_subcellular_location: Secreted.
  uniprot_function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan
    which are essential to cells undergoing biological processes.
  uniprot_features: &id133
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id134
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:14718574
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8952289
- organism: human
  gene: ITIH2
  row_index: 12
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ITIH2 is a major plasma protein present at high concentrations in blood. Detection in blood microparticle
    preparations likely reflects the plasma milieu in which these particles exist rather than specific functional association
    with microparticles. The title of PMID:22516433 indicates "high individual variability" in the proteomic analysis, suggesting
    some non-specific associations. While this annotation may be technically correct, it does not represent a core functional
    localization for ITIH2, whose primary functions are in plasma and ECM.
  uniprot_subcellular_location: Secreted.
  uniprot_function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan
    which are essential to cells undergoing biological processes.
  uniprot_features: *id133
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id134
- organism: human
  gene: ITIH2
  row_index: 13
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This is the same issue as the previous exosomal annotation but from a different study. PMID:20458337 analyzed
    "MHC class II-associated proteins in B-cell exosomes." While ITIH2 was detected, as an abundant plasma protein, it likely
    represents contamination rather than specific functional association with B-cell exosomes. The core functions of ITIH2
    relate to ECM stabilization and hyaluronan binding, not exosome biology. Keep as non-core.
  uniprot_subcellular_location: Secreted.
  uniprot_function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan
    which are essential to cells undergoing biological processes.
  uniprot_features: *id133
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id134
- organism: human
  gene: ITIH3
  row_index: 6
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA observation is retained, but ITIH3 is a soluble secreted plasma protein and may co-purify with extracellular-vesicle
    preparations. The study does not establish vesicle incorporation or an exosomal function.
  uniprot_subcellular_location: Secreted.
  uniprot_function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix
    protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan
    which are essential to cells undergoing biological processes.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-481009
  - term: GO:0031089 platelet dense granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481009
- organism: human
  gene: ITIH4
  row_index: 7
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This is a legitimate HDA dataset observation but not a core location. The source explicitly notes that some
    proteins in these preparations may also be soluble, a substantial caveat for abundant secreted plasma ITIH4.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in
    liver development or regeneration. {ECO:0000269|PubMed:19263524}.
  uniprot_features: &id135
  - SIGNAL
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id136
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-481009
  - term: GO:0031089 platelet dense granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-481009
- organism: human
  gene: ITIH4
  row_index: 8
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The proteomic recovery supports a contextual blood-microparticle association, but it does not establish
    that vesicle packaging is required for ITIH4's inhibitor function. The robust core pool is soluble plasma/extracellular
    space.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in
    liver development or regeneration. {ECO:0000269|PubMed:19263524}.
  uniprot_features: *id135
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id136
- organism: human
  gene: ITIH4
  row_index: 9
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The HDA is retained as a vesicle-preparation observation, but it does not show intraluminal incorporation
    or a functional exosome role. Secreted plasma/urinary ITIH4 can co-purify with extracellular vesicles.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in
    liver development or regeneration. {ECO:0000269|PubMed:19263524}.
  uniprot_features: *id135
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id136
- organism: human
  gene: KHK
  row_index: 14
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Bulk proteomic detection of a highly expressed cytosolic enzyme in exosomes is common and not indicative
    of a functional extracellular/vesicular role. Retained as non-core localization evidence rather than accepted as a core
    cellular component.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. {ECO:0000269|PubMed:12941785}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000054
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5656459
    - TAS Reactome:R-HSA-70333
- organism: human
  gene: KL
  row_index: 88
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in urinary vesicles is consistent with KL expression in renal and prostate epithelia
    and release into urine, but exosomal localization has no known functional role for KL.
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}; Single-pass
    type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane
    protein {ECO:0000250|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000250|UniProtKB:O35082}.
    [Isoform 2]: Secreted {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}. [Klotho peptide]: Secreted {ECO:0000250|UniProtKB:O35082}.'
  uniprot_function: Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl
    hydrolase 1 family enzymes (By similarity). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide,
    estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (By si ...
  uniprot_features: &id137
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id138
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:10631108
    - EXP PMID:15135068
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-109699
    - TAS Reactome:R-HSA-190268
    - TAS Reactome:R-HSA-191062
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-5654149
    - TAS Reactome:R-HSA-5654165
    - TAS Reactome:R-HSA-5654167
    - TAS Reactome:R-HSA-5654392
    - TAS Reactome:R-HSA-5654560
    - TAS Reactome:R-HSA-5654569
    - TAS Reactome:R-HSA-5654571
    - TAS Reactome:R-HSA-5654573
    - TAS Reactome:R-HSA-5654575
    - TAS Reactome:R-HSA-5654578
    - TAS Reactome:R-HSA-5654582
    - TAS Reactome:R-HSA-5654584
    - TAS Reactome:R-HSA-5654586
    - TAS Reactome:R-HSA-5654587
    - TAS Reactome:R-HSA-5654591
    - TAS Reactome:R-HSA-5654592
    - TAS Reactome:R-HSA-5654594
    - TAS Reactome:R-HSA-5654596
    - TAS Reactome:R-HSA-5654597
    - TAS Reactome:R-HSA-5654600
    - TAS Reactome:R-HSA-5654672
    - TAS Reactome:R-HSA-5654673
    - TAS Reactome:R-HSA-5654690
    - TAS Reactome:R-HSA-5654692
    - TAS Reactome:R-HSA-5656064
    - TAS Reactome:R-HSA-5672965
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:10631108
    - EXP PMID:15135068
    - IEA GO_REF:0000044
    - TAS PMID:9464267
    - TAS Reactome:R-HSA-109699
    - TAS Reactome:R-HSA-190268
    - TAS Reactome:R-HSA-191062
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-5654149
    - TAS Reactome:R-HSA-5654165
    - TAS Reactome:R-HSA-5654167
    - TAS Reactome:R-HSA-5654392
    - TAS Reactome:R-HSA-5654560
    - TAS Reactome:R-HSA-5654569
    - TAS Reactome:R-HSA-5654571
    - TAS Reactome:R-HSA-5654573
    - TAS Reactome:R-HSA-5654575
    - TAS Reactome:R-HSA-5654578
    - TAS Reactome:R-HSA-5654582
    - TAS Reactome:R-HSA-5654584
    - TAS Reactome:R-HSA-5654586
    - TAS Reactome:R-HSA-5654587
    - TAS Reactome:R-HSA-5654591
    - TAS Reactome:R-HSA-5654592
    - TAS Reactome:R-HSA-5654594
    - TAS Reactome:R-HSA-5654596
    - TAS Reactome:R-HSA-5654597
    - TAS Reactome:R-HSA-5654600
    - TAS Reactome:R-HSA-5654672
    - TAS Reactome:R-HSA-5654673
    - TAS Reactome:R-HSA-5654690
    - TAS Reactome:R-HSA-5654692
    - TAS Reactome:R-HSA-5656064
    - TAS Reactome:R-HSA-5672965
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
- organism: human
  gene: KL
  row_index: 89
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in urinary vesicles is consistent with KL expression in renal and prostate epithelia
    and release into urine, but exosomal localization has no known functional role for KL.
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}; Single-pass
    type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane
    protein {ECO:0000250|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000250|UniProtKB:O35082}.
    [Isoform 2]: Secreted {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}. [Klotho peptide]: Secreted {ECO:0000250|UniProtKB:O35082}.'
  uniprot_function: Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl
    hydrolase 1 family enzymes (By similarity). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide,
    estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (By si ...
  uniprot_features: *id137
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id138
- organism: human
  gene: LAMP1
  row_index: 60
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain as non-core context while prioritizing lysosomal/late endosomal membrane annotations.
  uniprot_subcellular_location: Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass
    type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16176980}; Single- pass type I membrane protein
    {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}.
    Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}.
    Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein
    {ECO:0000255}. Note ...
  uniprot_function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation,
    autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation
    by acting as a direct inhibitor of the proton channel TMEM175, facil ...
  uniprot_features: &id139
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id140
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:21266579
  - term: GO:0005764 lysosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:15613468
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:15052268
    - IDA PMID:15292400
    - IDA PMID:16542649
    - IDA PMID:22792322
    - IDA PMID:23704327
    - IDA PMID:25365221
    - IEA GO_REF:0000107
    - TAS PMID:3131762
  - term: GO:0005765 lysosomal membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:16176980
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - EXP PMID:17897319
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IDA PMID:15052268
    - IDA PMID:15292400
    - IDA PMID:15792797
    - IDA PMID:16542649
    - IDA PMID:18388320
    - IDA PMID:18767904
    - IEA GO_REF:0000107
  - term: GO:0005771 multivesicular body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:2022921
    - EXP PMID:23847195
    - IDA PMID:20956541
    - IEA GO_REF:0000044
    - TAS PMID:3174652
    - TAS Reactome:R-HSA-6798739
    - TAS Reactome:R-HSA-6800426
  - term: GO:0008021 synaptic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:16176980
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - TAS PMID:3174652
  - term: GO:0031902 late endosome membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:16176980
    - IEA GO_REF:0000044
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0035577 azurophil granule membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-6798739
  - term: GO:0042383 sarcolemma
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0044194 cytolytic granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0044754 autolysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045335 phagocytic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IMP PMID:18787122
  - term: GO:0061474 phagolysosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0101003 ficolin-1-rich granule membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-6800426
  - term: GO:0101004 cytolytic granule membrane
    qualifier: located_in
    evidence:
    - EXP PMID:2022921
    - IDA PMID:24088571
    - IEA GO_REF:0000044
- organism: human
  gene: LAMP1
  row_index: 69
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain as non-core context while prioritizing lysosomal/late endosomal membrane annotations.
  uniprot_subcellular_location: Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass
    type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16176980}; Single- pass type I membrane protein
    {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}.
    Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}.
    Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein
    {ECO:0000255}. Note ...
  uniprot_function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation,
    autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation
    by acting as a direct inhibitor of the proton channel TMEM175, facil ...
  uniprot_features: *id139
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id140
- organism: human
  gene: LCK
  row_index: 229
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection; acylated membrane kinases are frequently captured in exosome preparations. Not
    a site of function.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}; Lipid-anchor {ECO:0000269|PubMed:12218089,
    ECO:0000269|PubMed:22034844}; Cytoplasmic side {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}. Cytoplasm,
    cytosol {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}. Note=Present in lipid rafts in an inactive form. {ECO:0000269|PubMed:12218089}.
  uniprot_function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing
    T-cells in the thymus and in the function of mature T-cells (PubMed:2470098). Plays a key role in T-cell antigen receptor
    (TCR)-linked signal transduction pathways (PubMed:2470098). Consti ...
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000242 pericentriolar material
    qualifier: located_in
    evidence:
    - IDA PMID:7513706
  - term: GO:0001772 immunological synapse
    qualifier: located_in
    evidence:
    - IDA PMID:20007709
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IDA PMID:38614099
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1433418
    - TAS Reactome:R-HSA-1433428
    - TAS Reactome:R-HSA-1433451
    - TAS Reactome:R-HSA-1433454
    - TAS Reactome:R-HSA-1433456
    - TAS Reactome:R-HSA-1433488
    - TAS Reactome:R-HSA-1433506
    - TAS Reactome:R-HSA-1433514
    - TAS Reactome:R-HSA-1433542
    - TAS Reactome:R-HSA-1470009
    - TAS Reactome:R-HSA-1470010
    - TAS Reactome:R-HSA-1470012
    - TAS Reactome:R-HSA-1472121
    - TAS Reactome:R-HSA-1562641
    - TAS Reactome:R-HSA-167566
    - TAS Reactome:R-HSA-200954
    - TAS Reactome:R-HSA-202165
    - TAS Reactome:R-HSA-202168
    - TAS Reactome:R-HSA-202174
    - TAS Reactome:R-HSA-202214
    - TAS Reactome:R-HSA-202216
    - TAS Reactome:R-HSA-202233
    - TAS Reactome:R-HSA-202245
    - TAS Reactome:R-HSA-202248
    - TAS Reactome:R-HSA-202291
    - TAS Reactome:R-HSA-202307
    - TAS Reactome:R-HSA-202344
    - TAS Reactome:R-HSA-205234
    - TAS Reactome:R-HSA-205238
    - TAS Reactome:R-HSA-205244
    - TAS Reactome:R-HSA-205319
    - TAS Reactome:R-HSA-210289
    - TAS Reactome:R-HSA-210291
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2395412
    - TAS Reactome:R-HSA-2395801
    - TAS Reactome:R-HSA-2396594
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-2424480
    - TAS Reactome:R-HSA-2424482
    - TAS Reactome:R-HSA-2424484
    - TAS Reactome:R-HSA-2424486
    - TAS Reactome:R-HSA-2424487
    - TAS Reactome:R-HSA-388814
    - TAS Reactome:R-HSA-388829
    - TAS Reactome:R-HSA-388831
    - TAS Reactome:R-HSA-388832
    - TAS Reactome:R-HSA-388833
    - TAS Reactome:R-HSA-389158
    - TAS Reactome:R-HSA-389348
    - TAS Reactome:R-HSA-389350
    - TAS Reactome:R-HSA-389352
    - TAS Reactome:R-HSA-389354
    - TAS Reactome:R-HSA-389381
    - TAS Reactome:R-HSA-389758
    - TAS Reactome:R-HSA-389759
    - TAS Reactome:R-HSA-389762
    - TAS Reactome:R-HSA-434836
    - TAS Reactome:R-HSA-8852200
    - TAS Reactome:R-HSA-8855381
    - TAS Reactome:R-HSA-9018758
    - TAS Reactome:R-HSA-9670412
    - TAS Reactome:R-HSA-9670413
    - TAS Reactome:R-HSA-9670414
    - TAS Reactome:R-HSA-9670416
    - TAS Reactome:R-HSA-9670417
    - TAS Reactome:R-HSA-9670418
    - TAS Reactome:R-HSA-9670426
    - TAS Reactome:R-HSA-9706312
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:12218089
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:22034844
    - IDA PMID:12150984
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-202214
    - TAS Reactome:R-HSA-202233
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:12150984
    - IDA PMID:12732664
- organism: human
  gene: LFNG
  row_index: 25
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection; not a site of function.
  uniprot_subcellular_location: Golgi apparatus {ECO:0000250|UniProtKB:O09010}. Golgi apparatus membrane {ECO:0000305}; Single-pass
    type II membrane protein {ECO:0000305}.
  uniprot_function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats
    in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific
    EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and e ...
  uniprot_features:
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-5096538
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - NAS PMID:10341080
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
- organism: human
  gene: LGALS3
  row_index: 64
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics localization; consistent with secretion but not core or functional.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}.
    Note=Secreted by a non- classical secretory pathway and associates with the cell surface. Can be secreted; the secretion
    is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from
    the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion
    (PubMed:32272059). {ECO:0000269|PubMed:32272059}.
  uniprot_function: 'Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation
    by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial
    cells during early embryogenesis (By similarity). In the nucleus: acts a ...'
  uniprot_features: &id141 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id142
  - term: GO:0001772 immunological synapse
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0001772 immunological synapse
    qualifier: located_in
    evidence:
    - IDA PMID:19706535
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IDA PMID:26582946
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:32272059
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:14961764
    - IDA PMID:22761016
    - IDA PMID:7682704
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:32272059
    - IDA PMID:14961764
    - IDA PMID:22761016
    - IDA PMID:9447709
    - IEA GO_REF:0000044
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - IDA PMID:19016746
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS PMID:9162064
    - TAS Reactome:R-HSA-6798743
    - TAS Reactome:R-HSA-6800426
    - TAS Reactome:R-HSA-8938382
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0030667 secretory granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0031012 extracellular matrix
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0101003 ficolin-1-rich granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800426
- organism: human
  gene: LGALS3
  row_index: 94
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics localization consistent with secretion; not core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}.
    Note=Secreted by a non- classical secretory pathway and associates with the cell surface. Can be secreted; the secretion
    is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from
    the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion
    (PubMed:32272059). {ECO:0000269|PubMed:32272059}.
  uniprot_function: 'Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation
    by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial
    cells during early embryogenesis (By similarity). In the nucleus: acts a ...'
  uniprot_features: *id141
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id142
- organism: human
  gene: LGALS3
  row_index: 95
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics localization consistent with secretion; not core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}.
    Note=Secreted by a non- classical secretory pathway and associates with the cell surface. Can be secreted; the secretion
    is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from
    the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion
    (PubMed:32272059). {ECO:0000269|PubMed:32272059}.
  uniprot_function: 'Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation
    by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial
    cells during early embryogenesis (By similarity). In the nucleus: acts a ...'
  uniprot_features: *id141
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id142
- organism: human
  gene: LOXL4
  row_index: 20
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain this curator-reviewed high-throughput localization with its exact parotid gland extension. It represents
    a tissue- and vesicle-specific occurrence rather than the general extracellular-matrix site of LOXL4 catalytic activity.
  uniprot_subcellular_location: Secreted, extracellular space {ECO:0000305}.
  uniprot_function: Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting
    in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. {ECO:0000269|PubMed:14551188}.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0031012 extracellular matrix
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043235 signaling receptor complex
    qualifier: part_of
    evidence:
    - IDA PMID:23382219
  - term: GO:0071953 elastic fiber
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS PMID:23962539
- organism: human
  gene: LPO
  row_index: 18
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in parotid exosome preparations is a high-throughput secretion-context observation and does not
    establish exosome-dependent LPO function. The experimental or curator-attributed assertion is retained with curator deference.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:12626341}. Cytoplasm {ECO:0000250|UniProtKB:Q5SW46}.
  uniprot_function: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial
    agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (PubMed:6295491). Also involved in the
    conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:12626341
    - IDA PMID:24248522
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-8855490
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0016323 basolateral plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:19059195
- organism: human
  gene: LRG1
  row_index: 37
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The high-throughput detection is retained with curator deference, but exosome association is sample-specific
    and not necessary to define LRG1's secreted signaling role.
  uniprot_subcellular_location: Secreted.
  uniprot_function: ''
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:20363744
    - IEA GO_REF:0000120
    - NAS PMID:12223515
    - NAS PMID:14718574
    - TAS Reactome:R-HSA-6798745
    - TAS Reactome:R-HSA-6798749
    - TAS Reactome:R-HSA-6800434
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - NAS PMID:3856868
  - term: GO:0035580 specific granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798749
  - term: GO:0140149 non-collagenous component of interstitial matrix
    qualifier: located_in
    evidence:
    - TAS PMID:36399478
  - term: GO:1904724 tertiary granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: LRP2
  row_index: 104
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The location is biologically compatible, but it is broad, secondary, or tissue-contextual rather than the
    defining apical-plasma-membrane/endocytic route of LRP2.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:23825075, ECO:0000269|PubMed:27798286}; Single-pass
    type I membrane protein {ECO:0000255}. Endosome lumen {ECO:0000250|UniProtKB:P98158}. Membrane, coated pit {ECO:0000250|UniProtKB:A2ARV4}.
    Cell projection, dendrite {ECO:0000250|UniProtKB:A2ARV4}. Cell projection, axon {ECO:0000250|UniProtKB:A2ARV4}. Note=Localizes
    to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes
    as a soluble form. {ECO:0000250|UniProtKB:P98158}.
  uniprot_function: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density
    lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides
    and polymyxin B (By similarity). In the kidney, mediates the tubular up ...
  uniprot_features: &id143
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id144
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - TAS PMID:7768901
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS Reactome:R-HSA-2404131
    - TAS Reactome:R-HSA-350168
    - TAS Reactome:R-HSA-8863472
    - TAS Reactome:R-HSA-8867754
    - TAS Reactome:R-HSA-8867756
    - TAS Reactome:R-HSA-8868071
    - TAS Reactome:R-HSA-8868072
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-9759202
    - TAS Reactome:R-HSA-9759209
  - term: GO:0005903 brush border
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005905 clathrin-coated pit
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0016324 apical plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:27798286
    - IDA PMID:23825075
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0030139 endocytic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0030425 dendrite
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0030669 clathrin-coated endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
  - term: GO:0031526 brush border membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0031904 endosome lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0043235 signaling receptor complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:23382219
    - IEA GO_REF:0000117
    - ISS GO_REF:0000024
  - term: GO:0045177 apical part of cell
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: LRP2
  row_index: 106
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The location is biologically compatible, but it is broad, secondary, or tissue-contextual rather than the
    defining apical-plasma-membrane/endocytic route of LRP2.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:23825075, ECO:0000269|PubMed:27798286}; Single-pass
    type I membrane protein {ECO:0000255}. Endosome lumen {ECO:0000250|UniProtKB:P98158}. Membrane, coated pit {ECO:0000250|UniProtKB:A2ARV4}.
    Cell projection, dendrite {ECO:0000250|UniProtKB:A2ARV4}. Cell projection, axon {ECO:0000250|UniProtKB:A2ARV4}. Note=Localizes
    to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes
    as a soluble form. {ECO:0000250|UniProtKB:P98158}.
  uniprot_function: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density
    lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides
    and polymyxin B (By similarity). In the kidney, mediates the tubular up ...
  uniprot_features: *id143
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id144
- organism: human
  gene: LRRK2
  row_index: 334
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular exosome - secreted in exosomes.
  uniprot_subcellular_location: Cytoplasmic vesicle {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:16352719, ECO:0000269|PubMed:26014385}.
    Perikaryon {ECO:0000269|PubMed:17120249}. Golgi apparatus membrane {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:23395371,
    ECO:0000269|PubMed:38127736}; Peripheral membrane protein {ECO:0000269|PubMed:16321986}. Cell projection, axon {ECO:0000269|PubMed:17120249}.
    Cell projection, dendrite {ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:21850687}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16321986,
    ECO:0000269|PubMed:25201882}; Peripheral membrane protein {ECO:0000269|PubMe ...
  uniprot_function: Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes
    such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687,
    PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16321986
    - IDA PMID:16352719
    - IDA PMID:19625296
    - IEA GO_REF:0000107
    - IMP PMID:26014385
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA PMID:21850687
  - term: GO:0005741 mitochondrial outer membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA PMID:23395371
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005798 Golgi-associated vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:24510904
  - term: GO:0005802 trans-Golgi network
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:21850687
    - IDA PMID:22736029
    - IDA PMID:22899650
    - IDA PMID:24403142
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-8857565
    - TAS Reactome:R-HSA-8857577
    - TAS Reactome:R-HSA-8857583
    - TAS Reactome:R-HSA-9634702
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:22899650
    - IEA GO_REF:0000120
  - term: GO:0005902 microvillus
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
  - term: GO:0008021 synaptic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IDA PMID:17120249
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0030425 dendrite
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0030425 dendrite
    qualifier: located_in
    evidence:
    - IDA PMID:17120249
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0030426 growth cone
    qualifier: located_in
    evidence:
    - IDA PMID:19625296
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0031966 mitochondrial membrane
    qualifier: located_in
    evidence:
    - IDA PMID:22736029
  - term: GO:0032473 cytoplasmic side of mitochondrial outer membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16269541
  - term: GO:0032839 dendrite cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:21696411
  - term: GO:0043005 neuron projection
    qualifier: located_in
    evidence:
    - IDA PMID:19625296
    - IDA PMID:21048939
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IDA PMID:21048939
    - IDA PMID:21696411
    - IEA GO_REF:0000107
  - term: GO:0043195 terminal bouton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS PMID:21563316
  - term: GO:0043204 perikaryon
    qualifier: located_in
    evidence:
    - IDA PMID:17120249
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0044753 amphisome
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
  - term: GO:0044754 autolysosome
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0045202 synapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045335 phagocytic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0070013 intracellular organelle lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0070971 endoplasmic reticulum exit site
    qualifier: located_in
    evidence:
    - IDA PMID:25201882
    - IEA GO_REF:0000120
  - term: GO:0097413 Lewy body
    qualifier: located_in
    evidence:
    - IDA PMID:27273569
  - term: GO:0097487 multivesicular body, internal vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
  - term: GO:0098794 postsynapse
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099400 caveola neck
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
  - term: GO:0099523 presynaptic cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:1990904 ribonucleoprotein complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1990909 Wnt signalosome
    qualifier: part_of
    evidence:
    - IDA PMID:22899650
    - IEA GO_REF:0000120
    - NAS PMID:24115276
- organism: human
  gene: LYN
  row_index: 299
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic detection in exosome/secretion preparations; not evidence of a functional exosomal
    role. Kept as non-core.
  uniprot_subcellular_location: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane
    {ECO:0000305}; Lipid- anchor {ECO:0000305}. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export.
    Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the
    plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic
    vesicular transport. Detected on plasma membrane lipid rafts.
  uniprot_function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important
    role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines,
    integrin signaling, but also responses to DNA damage and genotoxic  ...
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:18817770
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9707977
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:15173188
    - IDA PMID:20605918
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IDA PMID:11823534
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-114577
    - TAS Reactome:R-HSA-114600
    - TAS Reactome:R-HSA-1168459
    - TAS Reactome:R-HSA-139842
    - TAS Reactome:R-HSA-1433418
    - TAS Reactome:R-HSA-1433428
    - TAS Reactome:R-HSA-1433451
    - TAS Reactome:R-HSA-1433454
    - TAS Reactome:R-HSA-1433456
    - TAS Reactome:R-HSA-1433488
    - TAS Reactome:R-HSA-1433506
    - TAS Reactome:R-HSA-1433514
    - TAS Reactome:R-HSA-1433542
    - TAS Reactome:R-HSA-1470009
    - TAS Reactome:R-HSA-1470010
    - TAS Reactome:R-HSA-1470012
    - TAS Reactome:R-HSA-1472121
    - TAS Reactome:R-HSA-1562641
    - TAS Reactome:R-HSA-2029459
    - TAS Reactome:R-HSA-205234
    - TAS Reactome:R-HSA-205238
    - TAS Reactome:R-HSA-205244
    - TAS Reactome:R-HSA-205319
    - TAS Reactome:R-HSA-210291
    - TAS Reactome:R-HSA-388829
    - TAS Reactome:R-HSA-388831
    - TAS Reactome:R-HSA-388833
    - TAS Reactome:R-HSA-3928604
    - TAS Reactome:R-HSA-3928607
    - TAS Reactome:R-HSA-3928627
    - TAS Reactome:R-HSA-3928628
    - TAS Reactome:R-HSA-3928642
    - TAS Reactome:R-HSA-3928645
    - TAS Reactome:R-HSA-3928651
    - TAS Reactome:R-HSA-4093327
    - TAS Reactome:R-HSA-4093336
    - TAS Reactome:R-HSA-432295
    - TAS Reactome:R-HSA-437118
    - TAS Reactome:R-HSA-453183
    - TAS Reactome:R-HSA-453200
    - TAS Reactome:R-HSA-5621355
    - TAS Reactome:R-HSA-5624486
    - TAS Reactome:R-HSA-9012657
    - TAS Reactome:R-HSA-9021627
    - TAS Reactome:R-HSA-9027272
    - TAS Reactome:R-HSA-9027273
    - TAS Reactome:R-HSA-9027275
    - TAS Reactome:R-HSA-9027281
    - TAS Reactome:R-HSA-9029150
    - TAS Reactome:R-HSA-9664261
    - TAS Reactome:R-HSA-9664275
    - TAS Reactome:R-HSA-9670412
    - TAS Reactome:R-HSA-9670413
    - TAS Reactome:R-HSA-9670414
    - TAS Reactome:R-HSA-9670416
    - TAS Reactome:R-HSA-9670417
    - TAS Reactome:R-HSA-9670418
    - TAS Reactome:R-HSA-9670426
    - TAS Reactome:R-HSA-9709454
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:32958780
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:15173188
    - IDA PMID:20605918
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-2454208
    - TAS Reactome:R-HSA-2454240
    - TAS Reactome:R-HSA-2730833
    - TAS Reactome:R-HSA-2730843
    - TAS Reactome:R-HSA-2730851
    - TAS Reactome:R-HSA-2730862
    - TAS Reactome:R-HSA-2730882
    - TAS Reactome:R-HSA-2730884
    - TAS Reactome:R-HSA-2730886
    - TAS Reactome:R-HSA-5690702
    - TAS Reactome:R-HSA-9674816
    - TAS Reactome:R-HSA-9677579
    - TAS Reactome:R-HSA-9677585
  - term: GO:0005912 adherens junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:11823534
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030061 mitochondrial crista
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030666 endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9705738
    - TAS Reactome:R-HSA-9707977
  - term: GO:0031966 mitochondrial membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0034666 integrin alpha2-beta1 complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:11313396
    - IEA GO_REF:0000117
    - ISS GO_REF:0000024
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:20605918
    - IEA GO_REF:0000120
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099091 postsynaptic specialization, intracellular component
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: MAN1B1
  row_index: 40
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Large-scale proteomics detection; not a functional site of action.
  uniprot_subcellular_location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10409699}; Single-pass type II membrane
    protein {ECO:0000269|PubMed:10409699}.
  uniprot_function: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily
    trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations,
    as found in the ER quality control compartment (ERQC), it fu ...
  uniprot_features:
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:18003979
    - TAS PMID:10409699
    - TAS PMID:22160784
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - EXP PMID:10409699
    - IDA PMID:18003979
    - IEA GO_REF:0000044
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - TAS PMID:22160784
  - term: GO:0016020 membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:18003979
    - IEA GO_REF:0000002
    - TAS PMID:10521544
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:25411339
  - term: GO:0044322 endoplasmic reticulum quality control compartment
    qualifier: located_in
    evidence:
    - IDA PMID:18003979
    - TAS PMID:21062743
    - TAS Reactome:R-HSA-4793949
    - TAS Reactome:R-HSA-901024
    - TAS Reactome:R-HSA-901036
    - TAS Reactome:R-HSA-901039
    - TAS Reactome:R-HSA-901074
    - TAS Reactome:R-HSA-9036008
    - TAS Reactome:R-HSA-9036011
    - TAS Reactome:R-HSA-9036012
    - TAS Reactome:R-HSA-9696807
- organism: human
  gene: MGP
  row_index: 18
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This annotation is based on HDA evidence from proteomics identification of MGP in parotid gland exosomes.
    While technically correct, exosome localization is not a core functional location for MGP. Many secreted proteins can
    be found in exosomes as a byproduct of secretion pathways. MGP's primary and functionally relevant localization is the
    extracellular matrix of bone, cartilage, and vascular tissues where it inhibits calcification. This annotation should
    be kept as non-core to reflect that while MGP can be detected in exosomes, this is not its primary site of action.
  uniprot_subcellular_location: Secreted.
  uniprot_function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0031012 extracellular matrix
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - TAS PMID:9916809
- organism: human
  gene: MTHFD1
  row_index: 46
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cytoplasm {ECO:0000305|PubMed:3053686}.
  uniprot_function: 'Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate:
    (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945,
    PubMed:18767138, PubMed:1881876). These derivatives of  ...'
  uniprot_features: &id145 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id146
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - TAS PMID:3528153
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-200644
    - TAS Reactome:R-HSA-200661
    - TAS Reactome:R-HSA-200711
    - TAS Reactome:R-HSA-200718
    - TAS Reactome:R-HSA-200740
- organism: human
  gene: MTHFD1
  row_index: 48
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cytoplasm {ECO:0000305|PubMed:3053686}.
  uniprot_function: 'Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate:
    (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945,
    PubMed:18767138, PubMed:1881876). These derivatives of  ...'
  uniprot_features: *id145
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id146
- organism: human
  gene: MTHFD1
  row_index: 49
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cytoplasm {ECO:0000305|PubMed:3053686}.
  uniprot_function: 'Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate:
    (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945,
    PubMed:18767138, PubMed:1881876). These derivatives of  ...'
  uniprot_features: *id145
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id146
- organism: human
  gene: MUC1
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: MUC1 is legitimately found in extracellular exosomes, representing shed ectodomain or exosomal secretion.
    However, this is a consequence of shedding/secretion rather than a core functional location. The biological significance
    is uncertain - exosomal MUC1 may serve as a biomarker but is not a primary site of MUC1 function.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600};
    Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}.
    Note=Exclusively located in the apical domain of the plasma membrane of hig ...
  uniprot_function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein.
    May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal
    domain which is involved in cell signaling, through phosphorylation ...
  uniprot_features: &id147
  - LIPID
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id148
  - term: GO:0000785 chromatin
    qualifier: located_in
    evidence:
    - IDA PMID:15710329
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005796 Golgi lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1964501
    - TAS Reactome:R-HSA-1964505
    - TAS Reactome:R-HSA-5096532
    - TAS Reactome:R-HSA-5096537
    - TAS Reactome:R-HSA-5694487
    - TAS Reactome:R-HSA-6785524
    - TAS Reactome:R-HSA-6786012
    - TAS Reactome:R-HSA-913675
    - TAS Reactome:R-HSA-914005
    - TAS Reactome:R-HSA-914006
    - TAS Reactome:R-HSA-914008
    - TAS Reactome:R-HSA-914010
    - TAS Reactome:R-HSA-914012
    - TAS Reactome:R-HSA-914017
    - TAS Reactome:R-HSA-914018
    - TAS Reactome:R-HSA-977071
    - TAS Reactome:R-HSA-981497
    - TAS Reactome:R-HSA-981809
    - TAS Reactome:R-HSA-981814
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS PMID:1697589
    - TAS Reactome:R-HSA-6790022
    - TAS Reactome:R-HSA-8858500
  - term: GO:0016324 apical plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:15326289
- organism: human
  gene: MUC1
  row_index: 23
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Similar to exosome annotations - MUC1 is found in secreted vesicles but this represents shedding/secretion
    rather than a core functional location. This is a very generic term that could apply to many cellular compartments.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600};
    Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}.
    Note=Exclusively located in the apical domain of the plasma membrane of hig ...
  uniprot_function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein.
    May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal
    domain which is involved in cell signaling, through phosphorylation ...
  uniprot_features: *id147
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id148
- organism: human
  gene: MUC1
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same rationale as other exosome annotations - valid but non-core localization representing secretion/shedding.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600};
    Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}.
    Note=Exclusively located in the apical domain of the plasma membrane of hig ...
  uniprot_function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein.
    May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal
    domain which is involved in cell signaling, through phosphorylation ...
  uniprot_features: *id147
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id148
- organism: human
  gene: MUC1
  row_index: 27
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Same rationale as other exosome annotations - valid but non-core.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600};
    Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402,
    ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}.
    Note=Exclusively located in the apical domain of the plasma membrane of hig ...
  uniprot_function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein.
    May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal
    domain which is involved in cell signaling, through phosphorylation ...
  uniprot_features: *id147
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id148
- organism: human
  gene: MVB12A
  row_index: 36
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The core proteostasis role is ESCRT-I endosomal cargo sorting; this localization is secondary or broad.
  uniprot_subcellular_location: Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with F-actin. Some fraction
    may be nuclear.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and
    down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.
  uniprot_features: &id149 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id150
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:20654576
    - IDA PMID:22232651
    - IEA GO_REF:0000002
    - IPI PMID:18005716
    - IPI PMID:32424346
    - TAS PMID:20588296
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA PMID:18005716
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:20654576
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32424346
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:20654576
- organism: human
  gene: MVB12A
  row_index: 46
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The core proteostasis role is ESCRT-I endosomal cargo sorting; this localization is secondary or broad.
  uniprot_subcellular_location: Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with F-actin. Some fraction
    may be nuclear.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and
    down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.
  uniprot_features: *id149
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id150
- organism: human
  gene: MVB12B
  row_index: 31
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The core proteostasis role is ESCRT-I endosomal cargo sorting; this localization is secondary or broad.
  uniprot_subcellular_location: Endosome {ECO:0000305}. Late endosome membrane {ECO:0000305}; Peripheral membrane protein
    {ECO:0000305}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:20654576
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:22232651
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IDA PMID:22232651
  - term: GO:0005770 late endosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IDA PMID:22232651
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:22232651
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:22232651
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:20654576
- organism: human
  gene: NAGLU
  row_index: 14
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: NAGLU was identified in a bulk shotgun-proteomics survey of urinary/prostatic exosomes. Presence of lysosomal
    enzymes in secreted extracellular vesicles is a real but peripheral observation and does not reflect the core lysosomal
    catabolic function of the enzyme. Retained as a non-core localization.
  uniprot_subcellular_location: Lysosome.
  uniprot_function: Involved in the degradation of heparan sulfate.
  uniprot_features: &id151
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id152
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS PMID:8650226
  - term: GO:0005773 vacuole
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1678742
    - TAS Reactome:R-HSA-2090038
    - TAS Reactome:R-HSA-2263496
    - TAS Reactome:R-HSA-9036052
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:21082674
- organism: human
  gene: NAGLU
  row_index: 16
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: NAGLU was among the ~1132 proteins profiled in urinary exosomes by LC-MS/MS. Consistent with the other exosome
    detections; a real but non-core localization for a lysosomal hydrolase.
  uniprot_subcellular_location: Lysosome.
  uniprot_function: Involved in the degradation of heparan sulfate.
  uniprot_features: *id151
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id152
- organism: human
  gene: NAMPT
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted
    {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern
    within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-
    fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
  uniprot_function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide
    mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis
    pathway. The secreted form behaves both as a cytokine with immunomod ...
  uniprot_features: &id153 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id154
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:21741723
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:24130902
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-197250
- organism: human
  gene: NAMPT
  row_index: 27
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted
    {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern
    within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-
    fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
  uniprot_function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide
    mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis
    pathway. The secreted form behaves both as a cytokine with immunomod ...
  uniprot_features: *id153
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id154
- organism: human
  gene: NAPRT
  row_index: 13
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:17604275}.
  uniprot_function: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of
    beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010,
    PubMed:26042198). Helps prevent cellular oxidative stress via its role in NA ...
  uniprot_features: &id155 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id156
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:17604275
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-197186
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
- organism: human
  gene: NAPRT
  row_index: 14
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:17604275}.
  uniprot_function: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of
    beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010,
    PubMed:26042198). Helps prevent cellular oxidative stress via its role in NA ...
  uniprot_features: *id155
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id156
- organism: human
  gene: NCSTN
  row_index: 77
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics-derived secondary localization, not core (HDA).
  uniprot_subcellular_location: 'Membrane {ECO:0000269|PubMed:10993067, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421,
    ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:26776682}; Single-pass type I membrane protein
    {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546,
    ECO:0000269|PubMed:30630874}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10993067}; Single-pass type I membrane
    protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed: ...'
  uniprot_function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane
    cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:10993067,
    PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, Pu ...
  uniprot_features: &id157
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id158
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - NAS PMID:15274632
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:15274632
    - IEA GO_REF:0000107
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - NAS PMID:15274632
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA PMID:15274632
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15274632
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1251997
    - TAS Reactome:R-HSA-193682
    - TAS Reactome:R-HSA-205112
    - TAS Reactome:R-HSA-2220988
    - TAS Reactome:R-HSA-3928656
    - TAS Reactome:R-HSA-6798739
    - TAS Reactome:R-HSA-9013361
    - TAS Reactome:R-HSA-9017817
    - TAS Reactome:R-HSA-9839376
    - TAS Reactome:R-NUL-2197556
    - TAS Reactome:R-NUL-9604300
  - term: GO:0008021 synaptic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9010096
  - term: GO:0012505 endomembrane system
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - EXP PMID:25918421
    - EXP PMID:26623517
    - EXP PMID:26776682
    - IDA PMID:25043039
    - IDA PMID:26280335
    - IEA GO_REF:0000120
    - NAS PMID:10993067
  - term: GO:0030659 cytoplasmic vesicle membrane
    qualifier: located_in
    evidence:
    - EXP PMID:10993067
    - IEA GO_REF:0000044
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0035577 azurophil granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
  - term: GO:0042383 sarcolemma
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0042734 presynaptic membrane
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0070765 gamma-secretase complex
    qualifier: part_of
    evidence:
    - IDA PMID:12297508
    - IDA PMID:25043039
    - IDA PMID:26280335
    - IEA GO_REF:0000107
    - IGI PMID:12763021
    - IPI PMID:26280335
    - NAS PMID:22086926
  - term: GO:0097060 synaptic membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0099503 secretory vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
- organism: human
  gene: NCSTN
  row_index: 79
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics-derived secondary localization, not core (HDA).
  uniprot_subcellular_location: 'Membrane {ECO:0000269|PubMed:10993067, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421,
    ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:26776682}; Single-pass type I membrane protein
    {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546,
    ECO:0000269|PubMed:30630874}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10993067}; Single-pass type I membrane
    protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed: ...'
  uniprot_function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane
    cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:10993067,
    PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, Pu ...
  uniprot_features: *id157
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id158
- organism: human
  gene: NID1
  row_index: 31
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: While nidogen-1 can be detected in exosome preparations, this is not a primary or functional localization.
    Exosomes may contain basement membrane fragments or contamination from ECM. The core localization is basement membrane.
    Mark as non-core.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix, basement membrane.
  uniprot_function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also
    binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
  uniprot_features: &id159
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id160
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-2426450
    - TAS Reactome:R-HSA-3791319
  - term: GO:0005604 basement membrane
    qualifier: located_in
    evidence:
    - IDA PMID:22952693
    - IEA GO_REF:0000120
    - NAS PMID:1678389
  - term: GO:0031012 extracellular matrix
    qualifier: colocalizes_with
    evidence:
    - ISS PMID:22261194
  - term: GO:0031012 extracellular matrix
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0071944 cell periphery
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098637 protein complex involved in cell-matrix adhesion
    qualifier: part_of
    evidence:
    - NAS PMID:3109910
- organism: human
  gene: NID1
  row_index: 37
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Duplicate of previous exosome annotation. While detected in exosome preparations, this is not a primary
    functional localization. Mark as non-core.
  uniprot_subcellular_location: Secreted, extracellular space, extracellular matrix, basement membrane.
  uniprot_function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also
    binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
  uniprot_features: *id159
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id160
- organism: human
  gene: NME2
  row_index: 62
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: 'Cytoplasm {ECO:0000269|PubMed:17532299}. Nucleus {ECO:0000305|PubMed:19033359, ECO:0000305|PubMed:19435876,
    ECO:0000305|PubMed:25679041, ECO:0000305|PubMed:8392752}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}.
    Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral
    ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or
    laminin substrates. {ECO:0000269|PubMed:11919189}. [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear
    re ...'
  uniprot_function: 'Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside
    diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside
    triphosphate homeostasis (PubMed:11121025, PubMed:16313181, PubMed: ...'
  uniprot_features: &id161 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id162
  - term: GO:0001726 ruffle
    qualifier: located_in
    evidence:
    - IDA PMID:11919189
    - IEA GO_REF:0000044
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:15703214
    - IDA PMID:17532299
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-482619
    - TAS Reactome:R-HSA-482621
    - TAS Reactome:R-HSA-9748969
    - TAS Reactome:R-HSA-9748999
    - TAS Reactome:R-HSA-9755013
  - term: GO:0005925 focal adhesion
    qualifier: NOT|located_in
    evidence:
    - IDA PMID:11919189
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IDA PMID:11919189
    - IEA GO_REF:0000044
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0071944 cell periphery
    qualifier: located_in
    evidence:
    - IDA PMID:11919189
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: NME2
  row_index: 64
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: 'Cytoplasm {ECO:0000269|PubMed:17532299}. Nucleus {ECO:0000305|PubMed:19033359, ECO:0000305|PubMed:19435876,
    ECO:0000305|PubMed:25679041, ECO:0000305|PubMed:8392752}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}.
    Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral
    ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or
    laminin substrates. {ECO:0000269|PubMed:11919189}. [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear
    re ...'
  uniprot_function: 'Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside
    diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside
    triphosphate homeostasis (PubMed:11121025, PubMed:16313181, PubMed: ...'
  uniprot_features: *id161
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id162
- organism: human
  gene: NME2
  row_index: 65
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: 'Cytoplasm {ECO:0000269|PubMed:17532299}. Nucleus {ECO:0000305|PubMed:19033359, ECO:0000305|PubMed:19435876,
    ECO:0000305|PubMed:25679041, ECO:0000305|PubMed:8392752}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}.
    Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral
    ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or
    laminin substrates. {ECO:0000269|PubMed:11919189}. [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear
    re ...'
  uniprot_function: 'Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside
    diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside
    triphosphate homeostasis (PubMed:11121025, PubMed:16313181, PubMed: ...'
  uniprot_features: *id161
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id162
- organism: human
  gene: NPHS2
  row_index: 10
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in extracellular exosomes likely reflects the normal turnover and shedding of podocyte proteins
    rather than a core functional location. Podocin's primary function is at the slit diaphragm, not in exosomes. This annotation
    reflects proteomics detection but not functional localization.
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. [Isoform
    2]: Endoplasmic reticulum {ECO:0000269|PubMed:23648087}.'
  uniprot_function: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma
    membrane and the cytoskeleton.
  uniprot_features: &id163
  - INTRAMEM
  - LIPID
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id164
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS PMID:10742096
    - TAS Reactome:R-HSA-373734
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IDA PMID:17675666
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:11786407
    - IEA GO_REF:0000120
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:17675666
  - term: GO:0036057 slit diaphragm
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:11786407
    - IEA GO_REF:0000107
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:17675666
  - term: GO:0071944 cell periphery
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: NPHS2
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Similar to the other exosome annotation, detection of podocin in urinary exosomes reflects protein shedding
    rather than functional localization. This is not a core functional location for podocin.
  uniprot_subcellular_location: '[Isoform 1]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. [Isoform
    2]: Endoplasmic reticulum {ECO:0000269|PubMed:23648087}.'
  uniprot_function: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma
    membrane and the cytoskeleton.
  uniprot_features: *id163
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id164
- organism: human
  gene: NQO2
  row_index: 24
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Mass-spectrometry detection in an exosome preparation; NQO2 is fundamentally a cytosolic enzyme, so this
    is not a functionally informative localization.
  uniprot_subcellular_location: Cytoplasm.
  uniprot_function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones
    involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation
    of glutamate residues in prothrombin synthesis. {ECO:0000269|PubM ...
  uniprot_features: &id165 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id166
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:10945627
    - TAS Reactome:R-HSA-8936519
- organism: human
  gene: NQO2
  row_index: 25
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics detection in exosomes; not a functional localization for this cytosolic enzyme.
  uniprot_subcellular_location: Cytoplasm.
  uniprot_function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones
    involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation
    of glutamate residues in prothrombin synthesis. {ECO:0000269|PubM ...
  uniprot_features: *id165
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id166
- organism: human
  gene: NT5E
  row_index: 36
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor
    {ECO:0000269|PubMed:2129526}.
  uniprot_function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding
    nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587,
    PubMed:34403084). Shows a preference for ribonucleotide monophosphates ov ...
  uniprot_features: &id167
  - LIPID
  - SIGNAL
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id168
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:25644539
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:2129526
    - EXP PMID:24887587
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-109278
    - TAS Reactome:R-HSA-109291
    - TAS Reactome:R-HSA-8940070
    - TAS Reactome:R-HSA-8940074
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:2129526
    - IEA GO_REF:0000117
    - TAS PMID:2129526
- organism: human
  gene: NT5E
  row_index: 37
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor
    {ECO:0000269|PubMed:2129526}.
  uniprot_function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding
    nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587,
    PubMed:34403084). Shows a preference for ribonucleotide monophosphates ov ...
  uniprot_features: *id167
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id168
- organism: human
  gene: NT5E
  row_index: 38
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor
    {ECO:0000269|PubMed:2129526}.
  uniprot_function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding
    nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587,
    PubMed:34403084). Shows a preference for ribonucleotide monophosphates ov ...
  uniprot_features: *id167
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id168
- organism: human
  gene: NT5E
  row_index: 43
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor
    {ECO:0000269|PubMed:2129526}.
  uniprot_function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding
    nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587,
    PubMed:34403084). Shows a preference for ribonucleotide monophosphates ov ...
  uniprot_features: *id167
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id168
- organism: human
  gene: P3H1
  row_index: 32
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics localization peripheral to the core ER catalytic role; plausible given the documented secreted
    form but non-core.
  uniprot_subcellular_location: '[Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:19088120}. Secreted, extracellular
    space, extracellular matrix {ECO:0000250|UniProtKB:Q9R1J8}. Note=Secreted into the extracellular matrix as a chondroitin
    sulfate proteoglycan (CSPG). {ECO:0000250|UniProtKB:Q9R1J8}.'
  uniprot_function: Has prolyl 3-hydroxylase activity and catalyzes the post- translational formation of 3-hydroxyproline
    in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen trimers (PubMed:39245686).
    May be involved in the secretory pathway of cells. Has growth suppr ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - EXP PMID:19088120
    - IDA PMID:19846465
    - IDA PMID:20089953
    - IEA GO_REF:0000044
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1980233
    - TAS Reactome:R-HSA-2022073
    - TAS Reactome:R-HSA-8948226
    - TAS Reactome:R-HSA-8948230
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - ISS PMID:15044469
- organism: human
  gene: P4HB
  row_index: 89
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A high-throughput proteomic detection in exosomes; peripheral to the core ER function. Retained as non-core.
  uniprot_subcellular_location: Endoplasmic reticulum {ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:32149426}. Endoplasmic
    reticulum lumen {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:23475612}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
    Cell membrane {ECO:0000269|PubMed:21670307}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some
    cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and
    replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:1
    ...
  uniprot_function: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At
    the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore
    cause structural modifications of exofacial proteins. Inside the cell, se ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - NAS PMID:14718574
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IDA PMID:32149426
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:12095988
    - IDA PMID:23152784
    - IDA PMID:23475612
    - IDA PMID:24415753
    - IEA GO_REF:0000120
    - TAS PMID:3034602
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - EXP PMID:23475612
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-1650808
    - TAS Reactome:R-HSA-174786
    - TAS Reactome:R-HSA-2002460
    - TAS Reactome:R-HSA-264997
    - TAS Reactome:R-HSA-3341296
    - TAS Reactome:R-HSA-5358336
    - TAS Reactome:R-HSA-5358340
    - TAS Reactome:R-HSA-8866329
    - TAS Reactome:R-HSA-8948234
    - TAS Reactome:R-HSA-8950113
    - TAS Reactome:R-HSA-8950183
    - TAS Reactome:R-HSA-8950456
    - TAS Reactome:R-HSA-8952289
    - TAS Reactome:R-HSA-9737780
    - TAS Reactome:R-HSA-9817575
    - TAS Reactome:R-HSA-9918779
  - term: GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
    qualifier: located_in
    evidence:
    - IDA PMID:15308636
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:24415753
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IDA PMID:24415753
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:21670307
    - IEA GO_REF:0000107
  - term: GO:0016222 procollagen-proline 4-dioxygenase complex
    qualifier: part_of
    evidence:
    - IDA PMID:7753822
  - term: GO:0030027 lamellipodium
    qualifier: located_in
    evidence:
    - IDA PMID:24415753
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:24415753
  - term: GO:0034663 endoplasmic reticulum chaperone complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: PAFAH1B1
  row_index: 163
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection; not a functional location.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03141}. Nucleus membrane {ECO:0000255|HAMAP-
    Rule:MF_03141}. Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette
    in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules
    and to the centrosome. May localize to the nuclear membrane. {ECO:0000250}.
  uniprot_function: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase
    (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and
    participates in PAF inactivation. Regulates the PAF-AH (I) activity in a ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000235 astral microtubule
    qualifier: located_in
    evidence:
    - IDA PMID:11940666
  - term: GO:0000776 kinetochore
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0000776 kinetochore
    qualifier: located_in
    evidence:
    - IDA PMID:11056532
    - IDA PMID:11889140
    - IDA PMID:11940666
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005635 nuclear envelope
    qualifier: located_in
    evidence:
    - IDA PMID:11940666
    - IEA GO_REF:0000107
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - NAS PMID:15572112
  - term: GO:0005813 centrosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:21399614
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005819 spindle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - ISS PMID:8028668
    - TAS Reactome:R-HSA-141409
    - TAS Reactome:R-HSA-141422
    - TAS Reactome:R-HSA-141431
    - TAS Reactome:R-HSA-141439
    - TAS Reactome:R-HSA-1638803
    - TAS Reactome:R-HSA-1638821
    - TAS Reactome:R-HSA-2467809
    - TAS Reactome:R-HSA-2467811
    - TAS Reactome:R-HSA-2468287
    - TAS Reactome:R-HSA-2484822
    - TAS Reactome:R-HSA-2574840
    - TAS Reactome:R-HSA-2574845
    - TAS Reactome:R-HSA-3000310
    - TAS Reactome:R-HSA-3000319
    - TAS Reactome:R-HSA-375302
    - TAS Reactome:R-HSA-380272
    - TAS Reactome:R-HSA-380283
    - TAS Reactome:R-HSA-380294
    - TAS Reactome:R-HSA-380303
    - TAS Reactome:R-HSA-380311
    - TAS Reactome:R-HSA-380316
    - TAS Reactome:R-HSA-380455
    - TAS Reactome:R-HSA-380508
    - TAS Reactome:R-HSA-5617816
    - TAS Reactome:R-HSA-5626220
    - TAS Reactome:R-HSA-5626223
    - TAS Reactome:R-HSA-5626227
    - TAS Reactome:R-HSA-5626228
    - TAS Reactome:R-HSA-5626681
    - TAS Reactome:R-HSA-5626699
    - TAS Reactome:R-HSA-5638009
    - TAS Reactome:R-HSA-5666129
    - TAS Reactome:R-HSA-5666160
    - TAS Reactome:R-HSA-5666169
    - TAS Reactome:R-HSA-8848484
    - TAS Reactome:R-HSA-8849350
    - TAS Reactome:R-HSA-8853405
    - TAS Reactome:R-HSA-8853419
    - TAS Reactome:R-HSA-9648114
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005871 kinesin complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005875 microtubule associated complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:11889140
    - IEA GO_REF:0000120
  - term: GO:0005938 cell cortex
    qualifier: located_in
    evidence:
    - IDA PMID:11940666
  - term: GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex
    qualifier: part_of
    evidence:
    - EXP PMID:15572112
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
    - NAS PMID:15572112
  - term: GO:0015630 microtubule cytoskeleton
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0015630 microtubule cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030424 axon
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030426 growth cone
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031252 cell leading edge
    qualifier: colocalizes_with
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0031252 cell leading edge
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031514 motile cilium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0031965 nuclear membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031982 vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0032420 stereocilium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0090724 central region of growth cone
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098685 Schaffer collateral - CA1 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1904115 axon cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
- organism: human
  gene: PARD6B
  row_index: 30
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes from high-throughput proteomics is not necessarily functionally significant. This
    does not represent a core localization for PARD6B function.
  uniprot_subcellular_location: Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
  uniprot_function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved
    in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1,
    thereby preventing tight junction assembly. The PARD6-PARD3 complex links  ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-419981
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:12545177
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-419981
  - term: GO:0005923 bicellular tight junction
    qualifier: located_in
    evidence:
    - IDA PMID:12545177
    - IEA GO_REF:0000120
  - term: GO:0005938 cell cortex
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005938 cell cortex
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016324 apical plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045177 apical part of cell
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0070160 tight junction
    qualifier: located_in
    evidence:
    - NAS PMID:11257119
- organism: human
  gene: PCBD1
  row_index: 32
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosome proteomes is a common finding for abundant cytosolic proteins and does not indicate
    a functional extracellular localization for PCBD1. Not part of its core enzymatic or coactivator functions; retained as
    non-core (localization observation only).
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:24204001}. Nucleus {ECO:0000269|PubMed:24204001}. Note=Recruited
    to the nucleus through the interaction with HNF1B. {ECO:0000269|PubMed:24204001}.
  uniprot_function: Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins
    and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates
    the dimerization of homeodomain protein HNF1A and enhances its transc ...
  uniprot_features: &id169 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id170
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:24204001
    - IEA GO_REF:0000120
  - term: GO:0005654 nucleoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:24204001
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-71146
- organism: human
  gene: PCBD1
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: As above, exosomal detection reflects the abundance of this cytosolic protein rather than a dedicated extracellular
    function. Retained as non-core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:24204001}. Nucleus {ECO:0000269|PubMed:24204001}. Note=Recruited
    to the nucleus through the interaction with HNF1B. {ECO:0000269|PubMed:24204001}.
  uniprot_function: Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins
    and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates
    the dimerization of homeodomain protein HNF1A and enhances its transc ...
  uniprot_features: *id169
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id170
- organism: human
  gene: PDCD5
  row_index: 25
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: While the localization in exosomes may be real (HDA evidence from proteomics), this does not represent a
    functional location for PDCD5's characterized activities. It may represent secretion/clearance rather than active function.
  uniprot_subcellular_location: ''
  uniprot_function: May function in the process of apoptosis.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:19308289
    - IDA PMID:22914926
    - IDA PMID:24012345
    - IDA PMID:28051100
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
- organism: human
  gene: PDCD6IP
  row_index: 51
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This annotation reflects broad localization, similarity-based epithelial/tight-junction biology, or a secondary
    ALIX context rather than the core ESCRT adaptor roles in MVB/exosome/cytokinesis/autophagy.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QZA2}. Melanosome {ECO:0000269|PubMed:17081065}.
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}.
    Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9WU78}.
    Midbody, Midbody ring {ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}. Note=Identified by mass spectrometry
    in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component
    of the actomyos ...
  uniprot_function: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis,
    apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo
    proteins of the multivesicular body (MVB) for incorporation into in ...
  uniprot_features: []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads:
  - term: GO:0001772 immunological synapse
    qualifier: located_in
    evidence:
    - IDA PMID:19706535
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-9688832
    - TAS Reactome:R-HSA-9948266
  - term: GO:0005923 bicellular tight junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - EXP PMID:17081065
    - IEA GO_REF:0000044
  - term: GO:0042641 actomyosin
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:15326289
    - IDA PMID:16501490
    - IDA PMID:21276792
    - IDA PMID:23092844
  - term: GO:0070971 endoplasmic reticulum exit site
    qualifier: located_in
    evidence:
    - IMP PMID:16957052
  - term: GO:0090543 Flemming body
    qualifier: located_in
    evidence:
    - IDA PMID:18641129
    - IEA GO_REF:0000044
- organism: human
  gene: PGK1
  row_index: 45
  term: GO:0070062 extracellular exosome
  reference: PMID:11487543
  reference_title: Intestinal epithelial cells secrete exosome-like vesicles.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: PGK1 is an abundant cytosolic protein commonly detected in exosome proteomes; this reflects its secretion/exosomal
    presence rather than the core cytosolic glycolytic location.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:36849569}. Mitochondrion matrix {ECO:0000269|PubMed:26942675,
    ECO:0000269|PubMed:36849569}. Note=Hypoxic conditions promote mitochondrial targeting (PubMed:26942675). Targeted to the
    mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA
    mcPGK1 (PubMed:36849569). {ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:36849569}.
  uniprot_function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion
    of 1,3- diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and
    pyrimidine nucleotides can be used as substrates, but the activity is much l ...
  uniprot_features: &id171 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id172
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:11130727
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - IDA PMID:26942675
    - IDA PMID:36849569
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:36849569
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-70486
    - TAS Reactome:R-HSA-71850
    - TAS Reactome:R-HSA-9636658
    - TAS Reactome:R-HSA-9975250
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:25204797
- organism: human
  gene: PGK1
  row_index: 47
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Reflects incidental presence of an abundant cytosolic protein in exosome proteomes rather than the core
    function or location.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:36849569}. Mitochondrion matrix {ECO:0000269|PubMed:26942675,
    ECO:0000269|PubMed:36849569}. Note=Hypoxic conditions promote mitochondrial targeting (PubMed:26942675). Targeted to the
    mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA
    mcPGK1 (PubMed:36849569). {ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:36849569}.
  uniprot_function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion
    of 1,3- diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and
    pyrimidine nucleotides can be used as substrates, but the activity is much l ...
  uniprot_features: *id171
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id172
- organism: human
  gene: PGK1
  row_index: 50
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Reflects incidental exosomal presence of an abundant cytosolic protein, not the core function or location.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:36849569}. Mitochondrion matrix {ECO:0000269|PubMed:26942675,
    ECO:0000269|PubMed:36849569}. Note=Hypoxic conditions promote mitochondrial targeting (PubMed:26942675). Targeted to the
    mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA
    mcPGK1 (PubMed:36849569). {ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:36849569}.
  uniprot_function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion
    of 1,3- diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and
    pyrimidine nucleotides can be used as substrates, but the activity is much l ...
  uniprot_features: *id171
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id172
- organism: human
  gene: PGK1
  row_index: 51
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Reflects incidental exosomal presence of an abundant cytosolic protein, not the core function or location.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:36849569}. Mitochondrion matrix {ECO:0000269|PubMed:26942675,
    ECO:0000269|PubMed:36849569}. Note=Hypoxic conditions promote mitochondrial targeting (PubMed:26942675). Targeted to the
    mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA
    mcPGK1 (PubMed:36849569). {ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:36849569}.
  uniprot_function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion
    of 1,3- diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and
    pyrimidine nucleotides can be used as substrates, but the activity is much l ...
  uniprot_features: *id171
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id172
- organism: human
  gene: PGM1
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomic detection of the abundant cytosolic enzyme in secreted exosomes; represents a secondary localization
    rather than PGM1's functional site. Retained as non-core.
  uniprot_subcellular_location: '[Isoform 1]: Cytoplasm.'
  uniprot_function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate
    (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate
    (Probable) (PubMed:25288802). This enzyme participates in both the breakdown ...
  uniprot_features: &id173 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id174
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:1530890
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-5609939
    - TAS Reactome:R-HSA-9638125
    - TAS Reactome:R-HSA-9638127
  - term: GO:1904724 tertiary granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798745
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: PGM1
  row_index: 23
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: As above, a mass-spectrometry-based detection in exosomes; a common finding for abundant cytosolic enzymes
    and peripheral to PGM1's core function. Retained as non-core.
  uniprot_subcellular_location: '[Isoform 1]: Cytoplasm.'
  uniprot_function: Catalyzes the reversible isomerization of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate
    (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate
    (Probable) (PubMed:25288802). This enzyme participates in both the breakdown ...
  uniprot_features: *id173
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id174
- organism: human
  gene: PHGDH
  row_index: 13
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step
    of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to
    2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO ...
  uniprot_features: &id175 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id176
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-977348
- organism: human
  gene: PHGDH
  row_index: 14
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step
    of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to
    2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO ...
  uniprot_features: *id175
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id176
- organism: human
  gene: PHGDH
  row_index: 15
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step
    of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to
    2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO ...
  uniprot_features: *id175
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id176
- organism: human
  gene: PHGDH
  row_index: 16
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step
    of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to
    2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO ...
  uniprot_features: *id175
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id176
- organism: human
  gene: PI15
  row_index: 4
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The curator's high-throughput detection should be retained, but the source study notes that proteins in
    exosome-enriched clinical-fluid preparations may also be soluble or contaminating. Exosome association is contextual and
    is not required for PI15's defining secreted inhibitor activity.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:8882727}.
  uniprot_function: Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May
    play a role in facial patterning during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q98ST6, ECO:0000269|PubMed:8882727}.
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:8882727
    - IEA GO_REF:0000120
- organism: human
  gene: PKLR
  row_index: 23
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in an exosome/extracellular-vesicle proteome is a frequent incidental finding for highly abundant
    soluble glycolytic enzymes and does not reflect where PKLR performs its catalytic function (the cytosol). Retained as
    a non-core localization observation.
  uniprot_subcellular_location: ''
  uniprot_function: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of
    ATP, and which plays a key role in glycolysis (PubMed:11960989). Also produces the side product 2-phospholactate which
    can inhibit fructose-2,6- bisphosphate production (PubMed:27294321). 2-phospho ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-71670
    - TAS Reactome:R-HSA-9727857
- organism: human
  gene: PKM
  row_index: 53
  term: GO:0070062 extracellular exosome
  reference: PMID:12519789
  reference_title: Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function
    and multivesicular body formation.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal localization from proteomics study. Not primary functional location.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: &id177 []
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: &id178
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:17308100
    - IDA PMID:18191611
    - IDA PMID:27573352
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9766062
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000054
    - IDA PMID:18298799
    - IDA PMID:27573352
    - IEA GO_REF:0000044
  - term: GO:0005791 rough endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - NAS PMID:2813362
    - TAS Reactome:R-HSA-71670
    - TAS Reactome:R-HSA-9861640
  - term: GO:0005929 cilium
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: PKM
  row_index: 54
  term: GO:0070062 extracellular exosome
  reference: PMID:11487543
  reference_title: Intestinal epithelial cells secrete exosome-like vesicles.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal cargo. Not primary functional location.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 55
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular vesicle cargo from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 56
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal cargo from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 57
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Vesicular localization from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 61
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal cargo from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 62
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal cargo from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 64
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal cargo from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PKM
  row_index: 67
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosomal cargo from proteomics.
  uniprot_subcellular_location: '[Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352,
    ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988,
    ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:27573352, ECO:0000269|PubMed:32268273}.
    Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli
    (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylat ...'
  uniprot_function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from
    phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between
    the highly active tetrameric form and nearly inactive dimeric form determin ...
  uniprot_features: *id177
  gene_vesicle_rows: 9
  gene_vesicle_references: 9
  leads: *id178
- organism: human
  gene: PLD3
  row_index: 31
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes from high-throughput proteomics is consistent with PLD3's presence in the endolysosomal
    system (exosomes originate from multivesicular bodies). However, this is not a functional localization - the protein functions
    intracellularly in lysosomes.
  uniprot_subcellular_location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023};
    Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Lysosome lumen {ECO:0000269|PubMed:29386126,
    ECO:0000269|PubMed:30312375, ECO:0000305|PubMed:39423811}. Early endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass
    type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Late endosome membrane {ECO:0000269|PubMed:29386126};
    Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Golgi ...
  uniprot_function: 5'->3' exonuclease that hydrolyzes the phosphodiester bond of single-stranded DNA (ssDNA) and RNA molecules
    to form nucleoside 3'- monophosphates and 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894,
    PubMed:30312375, PubMed:34620855, PubMed:37225734, PubMed:37994783, P ...
  uniprot_features: &id179
  - TRANSMEM
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id180
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IDA PMID:29368044
    - IEA GO_REF:0000044
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15794758
    - IDA PMID:22428023
    - IEA GO_REF:0000120
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0012505 endomembrane system
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0031901 early endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:29386126
    - IEA GO_REF:0000044
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:29386126
    - IEA GO_REF:0000120
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - IDA PMID:30312375
    - IEA GO_REF:0000044
- organism: human
  gene: PLD3
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in exosomes is consistent with endolysosomal localization but does not represent
    the functional site of the enzyme.
  uniprot_subcellular_location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023};
    Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Lysosome lumen {ECO:0000269|PubMed:29386126,
    ECO:0000269|PubMed:30312375, ECO:0000305|PubMed:39423811}. Early endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass
    type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Late endosome membrane {ECO:0000269|PubMed:29386126};
    Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Golgi ...
  uniprot_function: 5'->3' exonuclease that hydrolyzes the phosphodiester bond of single-stranded DNA (ssDNA) and RNA molecules
    to form nucleoside 3'- monophosphates and 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894,
    PubMed:30312375, PubMed:34620855, PubMed:37225734, PubMed:37994783, P ...
  uniprot_features: *id179
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id180
- organism: human
  gene: PLD3
  row_index: 34
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in urinary exosomes from high-throughput proteomics. Consistent with but not the primary functional
    localization.
  uniprot_subcellular_location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023};
    Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Lysosome lumen {ECO:0000269|PubMed:29386126,
    ECO:0000269|PubMed:30312375, ECO:0000305|PubMed:39423811}. Early endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass
    type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Late endosome membrane {ECO:0000269|PubMed:29386126};
    Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Golgi ...
  uniprot_function: 5'->3' exonuclease that hydrolyzes the phosphodiester bond of single-stranded DNA (ssDNA) and RNA molecules
    to form nucleoside 3'- monophosphates and 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894,
    PubMed:30312375, PubMed:34620855, PubMed:37225734, PubMed:37994783, P ...
  uniprot_features: *id179
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id180
- organism: human
  gene: PM20D1
  row_index: 30
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection; primary location is extracellular space with lipoproteins
  uniprot_subcellular_location: Secreted {ECO:0000250|UniProtKB:Q8C165}.
  uniprot_function: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels
    by functioning as a bidirectional NAA synthase/hydrolase (PubMed:27374330). It condenses free fatty acids and free amino
    acids to generate NAAs and bidirectionally catalyzes the reverse hydroly ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-9673053
    - TAS Reactome:R-HSA-9673054
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: PNP
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome proteomics frequently recovers abundant cytosolic enzymes; this does not indicate a functional exosomal
    role for PNP.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000305|PubMed:22509282, ECO:0000305|PubMed:3029074}.
  uniprot_function: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules,
    with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:3029074, PubMed:9305964).
    Preferentially acts on 6-oxopurine nucleosides including i ...
  uniprot_features: &id181 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id182
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16930574
    - IDA PMID:3029074
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-112033
    - TAS Reactome:R-HSA-112034
    - TAS Reactome:R-HSA-74242
    - TAS Reactome:R-HSA-74249
    - TAS Reactome:R-HSA-9735775
    - TAS Reactome:R-HSA-9735789
    - TAS Reactome:R-HSA-9755044
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: PNP
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput exosome/proteomics detection of an abundant cytosolic enzyme; not its functional compartment.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000305|PubMed:22509282, ECO:0000305|PubMed:3029074}.
  uniprot_function: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules,
    with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:3029074, PubMed:9305964).
    Preferentially acts on 6-oxopurine nucleosides including i ...
  uniprot_features: *id181
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id182
- organism: human
  gene: PNP
  row_index: 43
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: As above; proteomic detection in exosomes does not establish a functional role.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000305|PubMed:22509282, ECO:0000305|PubMed:3029074}.
  uniprot_function: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules,
    with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:3029074, PubMed:9305964).
    Preferentially acts on 6-oxopurine nucleosides including i ...
  uniprot_features: *id181
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id182
- organism: human
  gene: PPIB
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: PPIB has a secreted pool, so exosome detection is plausible, but it is secondary to the core ER-lumen localization.
  uniprot_subcellular_location: Virion {ECO:0000269|PubMed:20147391}. Note=(Microbial infection). Endoplasmic reticulum lumen
    {ECO:0000269|PubMed:1530944}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
  uniprot_function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and
    may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
  uniprot_features: &id183
  - SIGNAL
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id184
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:20089953
    - TAS PMID:2000394
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:1530944
    - TAS Reactome:R-HSA-1980233
    - TAS Reactome:R-HSA-2022073
    - TAS Reactome:R-HSA-8948226
    - TAS Reactome:R-HSA-8948230
  - term: GO:0005790 smooth endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-9728804
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0034663 endoplasmic reticulum chaperone complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - EXP PMID:17081065
    - IEA GO_REF:0000044
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:15989969
- organism: human
  gene: PPIB
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomic-survey localization; secondary to the core ER-lumen localization.
  uniprot_subcellular_location: Virion {ECO:0000269|PubMed:20147391}. Note=(Microbial infection). Endoplasmic reticulum lumen
    {ECO:0000269|PubMed:1530944}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
  uniprot_function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and
    may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
  uniprot_features: *id183
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id184
- organism: human
  gene: PPIB
  row_index: 42
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomic-survey localization; secondary to the core ER-lumen localization.
  uniprot_subcellular_location: Virion {ECO:0000269|PubMed:20147391}. Note=(Microbial infection). Endoplasmic reticulum lumen
    {ECO:0000269|PubMed:1530944}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
  uniprot_function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and
    may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
  uniprot_features: *id183
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id184
- organism: human
  gene: PPIB
  row_index: 44
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A proteomic-survey localization; secondary to the core ER-lumen localization.
  uniprot_subcellular_location: Virion {ECO:0000269|PubMed:20147391}. Note=(Microbial infection). Endoplasmic reticulum lumen
    {ECO:0000269|PubMed:1530944}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
  uniprot_function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and
    may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
  uniprot_features: *id183
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id184
- organism: human
  gene: PPP2CA
  row_index: 141
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomics data. PPP2CA was detected in exosomes but this likely reflects its high cellular
    abundance (~1% of total protein) rather than a specific exosomal function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:39032490}. Nucleus {ECO:0000269|PubMed:16541025,
    ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:39032490}. Chromosome {ECO:0000269|PubMed:33243860,
    ECO:0000269|PubMed:34004147}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole
    {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres (PubMed:16541025).
    During mitosis, also found at spindle poles (PubMed:16541025). Centromeric localization requires the presence o ...
  uniprot_function: 'Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation
    of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430,
    PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed: ...'
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000159 protein phosphatase type 2A complex
    qualifier: part_of
    evidence:
    - IDA PMID:17055435
    - IDA PMID:17174897
    - IEA GO_REF:0000107
    - TAS PMID:11007961
  - term: GO:0000775 chromosome, centromeric region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0000785 chromatin
    qualifier: is_active_in
    evidence:
    - IDA PMID:33243860
    - IDA PMID:34004147
  - term: GO:0000922 spindle pole
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IDA PMID:33243860
    - IDA PMID:34004147
    - IDA PMID:39032490
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:11007961
    - NAS PMID:32647223
  - term: GO:0005694 chromosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IDA PMID:29063833
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - NAS PMID:11007961
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:39032490
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - TAS PMID:11007961
    - TAS Reactome:R-HSA-1295599
    - TAS Reactome:R-HSA-1295609
    - TAS Reactome:R-HSA-1295613
    - TAS Reactome:R-HSA-1295622
    - TAS Reactome:R-HSA-1295632
    - TAS Reactome:R-HSA-1549564
    - TAS Reactome:R-HSA-2995388
    - TAS Reactome:R-HSA-927813
    - TAS Reactome:R-HSA-927830
    - TAS Reactome:R-HSA-927836
    - TAS Reactome:R-HSA-934559
    - TAS Reactome:R-HSA-9667965
    - TAS Reactome:R-HSA-9865226
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0008287 protein serine/threonine phosphatase complex
    qualifier: part_of
    evidence:
    - IDA PMID:28167675
  - term: GO:0015630 microtubule cytoskeleton
    qualifier: located_in
    evidence:
    - NAS PMID:11007961
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - NAS PMID:11007961
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:16258073
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0090443 FAR/SIN/STRIPAK complex
    qualifier: part_of
    evidence:
    - IDA PMID:29063833
    - IDA PMID:33633399
    - IEA GO_REF:0000117
  - term: GO:0160232 INTAC complex
    qualifier: part_of
    evidence:
    - IDA PMID:33243860
    - IDA PMID:34004147
    - IDA PMID:34762484
    - IDA PMID:36869814
    - IDA PMID:37080207
    - IDA PMID:38570683
- organism: human
  gene: PPP2R1B
  row_index: 22
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes by mass spectrometry is common for abundant cytoplasmic proteins and does not necessarily
    indicate a functional role in exosome biology. While the detection is real, this is not a core function of PPP2R1B. Many
    PP2A subunits are detected in exosome proteomes.
  uniprot_subcellular_location: ''
  uniprot_function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly
    of the catalytic subunit and a variable regulatory B subunit.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000159 protein phosphatase type 2A complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IDA PMID:21172653
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: PRDX4
  row_index: 31
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retain the observation as non-core because proteomic localization can reflect cargo or context-specific
    detection. It should not displace the ER/cytoplasmic peroxiredoxin localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:18052930, ECO:0000269|PubMed:9388242}. Endoplasmic reticulum
    {ECO:0000269|PubMed:18052930}. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A
    small fraction of the protein is cytoplasmic. {ECO:0000269|PubMed:18052930}.
  uniprot_function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides
    to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
    and as sensor of hydrogen peroxide-mediated signaling events. Regulates the ac ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005783 endoplasmic reticulum
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000120
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000107
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: PRSS23
  row_index: 5
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A high-throughput mass-spectrometry identification in purified exosomes. It is compatible with the established
    secretion of PRSS23 and with its recovery from conditioned media, but exosomal co-purification is a common outcome for
    secreted proteins and does not establish that exosomes are where PRSS23 functions.
  uniprot_subcellular_location: Secreted {ECO:0000305}.
  uniprot_function: ''
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000054
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8952289
- organism: human
  gene: PSAP
  row_index: 62
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics-based exosome detection of the secreted form; non-core.
  uniprot_subcellular_location: 'Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.
    [Prosaposin]: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of
    complex glycans. {ECO:0000250|UniProtKB:Q61207}.'
  uniprot_function: Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for
    lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates
    from membranes and presenting them to their respective enzymes. They are deriv ...
  uniprot_features: &id185
  - SIGNAL
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id186
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:1454804
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
    - ISS PMID:22261194
    - TAS Reactome:R-HSA-351341
    - TAS Reactome:R-HSA-380073
    - TAS Reactome:R-HSA-5336182
    - TAS Reactome:R-HSA-5336184
    - TAS Reactome:R-HSA-749454
    - TAS Reactome:R-HSA-749456
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:22431521
    - IDA PMID:26370502
    - IDA PMID:28541286
    - IEA GO_REF:0000120
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1605591
    - TAS Reactome:R-HSA-9840334
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IDA PMID:26370502
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
  - term: GO:0035577 azurophil granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798739
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1605624
    - TAS Reactome:R-HSA-1605632
    - TAS Reactome:R-HSA-1605724
    - TAS Reactome:R-HSA-1605736
    - TAS Reactome:R-HSA-1606312
    - TAS Reactome:R-HSA-1606807
    - TAS Reactome:R-HSA-351341
    - TAS Reactome:R-HSA-9840334
    - TAS Reactome:R-HSA-9840470
    - TAS Reactome:R-HSA-9840488
    - TAS Reactome:R-HSA-9841189
    - TAS Reactome:R-HSA-9842115
- organism: human
  gene: PSAP
  row_index: 69
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomics-based exosome detection of the secreted form; non-core.
  uniprot_subcellular_location: 'Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.
    [Prosaposin]: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of
    complex glycans. {ECO:0000250|UniProtKB:Q61207}.'
  uniprot_function: Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for
    lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates
    from membranes and presenting them to their respective enzymes. They are deriv ...
  uniprot_features: *id185
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id186
- organism: human
  gene: PSAT1
  row_index: 15
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the
    glycolytic intermediate 3- phospho-D-glycerate into L-serine (PubMed:36851825, PubMed:37627284). Catalyzes the second
    step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohy ...
  uniprot_features: &id187 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id188
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-977333
- organism: human
  gene: PSAT1
  row_index: 16
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: ''
  uniprot_subcellular_location: ''
  uniprot_function: Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the
    glycolytic intermediate 3- phospho-D-glycerate into L-serine (PubMed:36851825, PubMed:37627284). Catalyzes the second
    step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohy ...
  uniprot_features: *id187
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id188
- organism: human
  gene: PSMA1
  row_index: 173
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as
    context without replacing the core catalytic/structural role.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345,
    ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2,
    which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
  uniprot_function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular
    proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.
    Associated with two 19S regulatory particles, forms the 26S proteasome  ...
  uniprot_features: &id189 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id190
  - term: GO:0000502 proteasome complex
    qualifier: part_of
    evidence:
    - IDA PMID:17323924
    - IEA GO_REF:0000107
    - IPI PMID:31283222
    - IPI PMID:34702852
    - IPI PMID:35714770
    - IPI PMID:35858375
    - NAS PMID:29636472
    - NAS PMID:30104634
    - NAS PMID:32134919
    - NAS PMID:33729481
    - NAS PMID:37228199
    - TAS PMID:8811196
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:34711951
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:12181345
    - IEA GO_REF:0000044
    - NAS PMID:32134919
    - NAS PMID:33019542
    - NAS PMID:35858375
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-174058
    - TAS Reactome:R-HSA-187574
    - TAS Reactome:R-HSA-188191
    - TAS Reactome:R-HSA-5635854
    - TAS Reactome:R-HSA-68825
    - TAS Reactome:R-HSA-69600
    - TAS Reactome:R-HSA-8939801
    - TAS Reactome:R-HSA-8952408
    - TAS Reactome:R-HSA-9762096
    - TAS Reactome:R-NUL-9604648
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IDA PMID:34711951
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:12181345
    - IEA GO_REF:0000044
    - NAS PMID:35858375
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - NAS PMID:12032076
    - TAS Reactome:R-HSA-1168640
    - TAS Reactome:R-HSA-1234159
    - TAS Reactome:R-HSA-1236970
    - TAS Reactome:R-HSA-1504193
    - TAS Reactome:R-HSA-174105
    - TAS Reactome:R-HSA-174202
    - TAS Reactome:R-HSA-174203
    - TAS Reactome:R-HSA-174255
    - TAS Reactome:R-HSA-180573
    - TAS Reactome:R-HSA-180603
    - TAS Reactome:R-HSA-209061
    - TAS Reactome:R-HSA-2130282
    - TAS Reactome:R-HSA-264458
    - TAS Reactome:R-HSA-353125
    - TAS Reactome:R-HSA-3640874
    - TAS Reactome:R-HSA-450466
    - TAS Reactome:R-HSA-4608855
    - TAS Reactome:R-HSA-4641256
    - TAS Reactome:R-HSA-4641260
    - TAS Reactome:R-HSA-5362448
    - TAS Reactome:R-HSA-5387392
    - TAS Reactome:R-HSA-5607724
    - TAS Reactome:R-HSA-5607731
    - TAS Reactome:R-HSA-5610754
    - TAS Reactome:R-HSA-5610758
    - TAS Reactome:R-HSA-5610760
    - TAS Reactome:R-HSA-5635868
    - TAS Reactome:R-HSA-5658430
    - TAS Reactome:R-HSA-5665854
    - TAS Reactome:R-HSA-5665871
    - TAS Reactome:R-HSA-5668481
    - TAS Reactome:R-HSA-5668520
    - TAS Reactome:R-HSA-5687112
    - TAS Reactome:R-HSA-5689539
    - TAS Reactome:R-HSA-68948
    - TAS Reactome:R-HSA-69016
    - TAS Reactome:R-HSA-75825
    - TAS Reactome:R-HSA-8850992
    - TAS Reactome:R-HSA-8852354
    - TAS Reactome:R-HSA-8854044
    - TAS Reactome:R-HSA-8854071
    - TAS Reactome:R-HSA-8866553
    - TAS Reactome:R-HSA-8866858
    - TAS Reactome:R-HSA-8932355
    - TAS Reactome:R-HSA-8956140
    - TAS Reactome:R-HSA-8956184
    - TAS Reactome:R-HSA-8957265
    - TAS Reactome:R-HSA-9755303
    - TAS Reactome:R-HSA-9755306
    - TAS Reactome:R-HSA-9766223
    - TAS Reactome:R-HSA-983150
    - TAS Reactome:R-HSA-9907898
    - TAS Reactome:R-HSA-9907912
    - TAS Reactome:R-HSA-9907919
    - TAS Reactome:R-HSA-9907925
    - TAS Reactome:R-HSA-9907928
    - TAS Reactome:R-HSA-9907940
    - TAS Reactome:R-HSA-9907941
    - TAS Reactome:R-HSA-9908052
    - TAS Reactome:R-HSA-9908069
    - TAS Reactome:R-HSA-9908101
    - TAS Reactome:R-HSA-9908178
    - TAS Reactome:R-HSA-9908709
    - TAS Reactome:R-HSA-9908721
    - TAS Reactome:R-HSA-9912636
    - TAS Reactome:R-HSA-9912655
    - TAS Reactome:R-HSA-9912747
    - TAS Reactome:R-HSA-9912751
    - TAS Reactome:R-HSA-9929352
    - TAS Reactome:R-HSA-9929486
    - TAS Reactome:R-HSA-9931314
    - TAS Reactome:R-HSA-9934893
    - TAS Reactome:R-HSA-9954728
    - TAS Reactome:R-NUL-212917
    - TAS Reactome:R-NUL-5610751
    - TAS Reactome:R-NUL-9011324
  - term: GO:0005839 proteasome core complex
    qualifier: part_of
    evidence:
    - IDA PMID:34711951
    - IEA GO_REF:0000120
    - IPI PMID:34702852
    - ISS GO_REF:0000024
  - term: GO:0008021 synaptic vesicle
    qualifier: located_in
    evidence:
    - NAS PMID:37228199
  - term: GO:0016604 nuclear body
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0019773 proteasome core complex, alpha-subunit complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IEA GO_REF:0000002
    - ISS GO_REF:0000024
  - term: GO:0034515 proteasome storage granule
    qualifier: located_in
    evidence:
    - NAS PMID:31380390
  - term: GO:1990111 spermatoproteasome complex
    qualifier: part_of
    evidence:
    - NAS PMID:35377789
- organism: human
  gene: PSMA1
  row_index: 175
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as
    context without replacing the core catalytic/structural role.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345,
    ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2,
    which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
  uniprot_function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular
    proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.
    Associated with two 19S regulatory particles, forms the 26S proteasome  ...
  uniprot_features: *id189
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id190
- organism: human
  gene: PSMA1
  row_index: 176
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as
    context without replacing the core catalytic/structural role.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345,
    ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2,
    which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
  uniprot_function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular
    proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.
    Associated with two 19S regulatory particles, forms the 26S proteasome  ...
  uniprot_features: *id189
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id190
- organism: human
  gene: PSMB5
  row_index: 140
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteasomes operate in cytosolic and nuclear compartments; localization annotations should be retained as
    context without replacing the core catalytic/structural role.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345,
    ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2,
    which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
  uniprot_function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular
    proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.
    Associated with two 19S regulatory particles, forms the 26S proteasome  ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000502 proteasome complex
    qualifier: part_of
    evidence:
    - IDA PMID:17323924
    - IPI PMID:34702852
    - IPI PMID:35714770
    - IPI PMID:35858375
    - NAS PMID:29636472
    - NAS PMID:32134919
    - NAS PMID:33729481
    - NAS PMID:37228199
    - TAS PMID:8811196
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:34711951
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:12181345
    - IEA GO_REF:0000044
    - NAS PMID:32134919
    - NAS PMID:35858375
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-174058
    - TAS Reactome:R-HSA-187574
    - TAS Reactome:R-HSA-188191
    - TAS Reactome:R-HSA-5635854
    - TAS Reactome:R-HSA-68825
    - TAS Reactome:R-HSA-69600
    - TAS Reactome:R-HSA-8939801
    - TAS Reactome:R-HSA-8952408
    - TAS Reactome:R-HSA-9762096
    - TAS Reactome:R-NUL-9604648
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IDA PMID:34711951
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:12181345
    - IEA GO_REF:0000044
    - NAS PMID:35858375
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - NAS PMID:12032076
    - TAS Reactome:R-HSA-1168640
    - TAS Reactome:R-HSA-1234159
    - TAS Reactome:R-HSA-1236970
    - TAS Reactome:R-HSA-1504193
    - TAS Reactome:R-HSA-174105
    - TAS Reactome:R-HSA-174202
    - TAS Reactome:R-HSA-174203
    - TAS Reactome:R-HSA-174255
    - TAS Reactome:R-HSA-180573
    - TAS Reactome:R-HSA-180603
    - TAS Reactome:R-HSA-209061
    - TAS Reactome:R-HSA-2130282
    - TAS Reactome:R-HSA-264458
    - TAS Reactome:R-HSA-353125
    - TAS Reactome:R-HSA-3640874
    - TAS Reactome:R-HSA-450466
    - TAS Reactome:R-HSA-4608855
    - TAS Reactome:R-HSA-4641256
    - TAS Reactome:R-HSA-4641260
    - TAS Reactome:R-HSA-5362448
    - TAS Reactome:R-HSA-5387392
    - TAS Reactome:R-HSA-5607724
    - TAS Reactome:R-HSA-5607731
    - TAS Reactome:R-HSA-5610754
    - TAS Reactome:R-HSA-5610758
    - TAS Reactome:R-HSA-5610760
    - TAS Reactome:R-HSA-5635868
    - TAS Reactome:R-HSA-5658430
    - TAS Reactome:R-HSA-5665854
    - TAS Reactome:R-HSA-5665871
    - TAS Reactome:R-HSA-5668481
    - TAS Reactome:R-HSA-5668520
    - TAS Reactome:R-HSA-5687112
    - TAS Reactome:R-HSA-5689539
    - TAS Reactome:R-HSA-68948
    - TAS Reactome:R-HSA-69016
    - TAS Reactome:R-HSA-75825
    - TAS Reactome:R-HSA-8850992
    - TAS Reactome:R-HSA-8852354
    - TAS Reactome:R-HSA-8854044
    - TAS Reactome:R-HSA-8854071
    - TAS Reactome:R-HSA-8866553
    - TAS Reactome:R-HSA-8866858
    - TAS Reactome:R-HSA-8932355
    - TAS Reactome:R-HSA-8956140
    - TAS Reactome:R-HSA-8956184
    - TAS Reactome:R-HSA-8957265
    - TAS Reactome:R-HSA-9755303
    - TAS Reactome:R-HSA-9755306
    - TAS Reactome:R-HSA-9766223
    - TAS Reactome:R-HSA-983150
    - TAS Reactome:R-HSA-9907898
    - TAS Reactome:R-HSA-9907919
    - TAS Reactome:R-HSA-9908101
    - TAS Reactome:R-HSA-9908178
    - TAS Reactome:R-HSA-9908709
    - TAS Reactome:R-HSA-9908721
    - TAS Reactome:R-HSA-9912636
    - TAS Reactome:R-HSA-9929352
    - TAS Reactome:R-HSA-9929486
    - TAS Reactome:R-HSA-9931314
    - TAS Reactome:R-HSA-9934893
    - TAS Reactome:R-HSA-9954728
    - TAS Reactome:R-NUL-212917
    - TAS Reactome:R-NUL-5610751
    - TAS Reactome:R-NUL-9011324
  - term: GO:0005839 proteasome core complex
    qualifier: part_of
    evidence:
    - IDA PMID:34711951
    - IEA GO_REF:0000120
    - IPI PMID:34702852
    - ISS GO_REF:0000024
  - term: GO:0008021 synaptic vesicle
    qualifier: located_in
    evidence:
    - NAS PMID:37228199
  - term: GO:0019774 proteasome core complex, beta-subunit complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - ISS GO_REF:0000024
  - term: GO:0034515 proteasome storage granule
    qualifier: located_in
    evidence:
    - NAS PMID:31380390
  - term: GO:1990111 spermatoproteasome complex
    qualifier: part_of
    evidence:
    - NAS PMID:35377789
- organism: human
  gene: PTPRC
  row_index: 127
  term: GO:0070062 extracellular exosome
  reference: PMID:12519789
  reference_title: Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function
    and multivesicular body formation.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Membrane protein carried on exosomes; non-core.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type
    I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Synapse {ECO:0000269|PubMed:35767951}.
    Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}.
  uniprot_function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951).
    Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity,
    while the second one seems to affect the substrate specificity ...
  uniprot_features: &id191
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id192
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:22174689
    - IDA PMID:12354383
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS PMID:2956090
    - TAS Reactome:R-HSA-202214
    - TAS Reactome:R-HSA-373746
    - TAS Reactome:R-HSA-6798743
  - term: GO:0005925 focal adhesion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17213291
    - IEA GO_REF:0000107
  - term: GO:0009898 cytoplasmic side of plasma membrane
    qualifier: located_in
    evidence:
    - NAS PMID:15661907
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:12100025
    - IDA PMID:12354383
    - IDA PMID:24337748
    - IEA GO_REF:0000120
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - TAS PMID:15095367
  - term: GO:0030667 secretory granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0032059 bleb
    qualifier: located_in
    evidence:
    - IDA PMID:12354383
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0045202 synapse
    qualifier: located_in
    evidence:
    - EXP PMID:35767951
    - IEA GO_REF:0000044
  - term: GO:0071944 cell periphery
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098552 side of membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0098857 membrane microdomain
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
- organism: human
  gene: PTPRC
  row_index: 128
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Membrane protein carried on exosomes; non-core.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type
    I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Synapse {ECO:0000269|PubMed:35767951}.
    Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}.
  uniprot_function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951).
    Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity,
    while the second one seems to affect the substrate specificity ...
  uniprot_features: *id191
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id192
- organism: human
  gene: QDPR
  row_index: 10
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Valid HDA proteomic observation but not a site of DHPR catalytic function; the enzyme acts intracellularly
    in the cytosolic BH4 salvage cycle. Keep as a non-core localization datum.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin. {ECO:0000269|PubMed:3033643,
    ECO:0000269|PubMed:8262916}.
  uniprot_features: &id193 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id194
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000054
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-71130
- organism: human
  gene: QDPR
  row_index: 11
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Corroborating HDA proteomic detection in exosomes; not a functional site of DHPR activity. Retain as non-core.
  uniprot_subcellular_location: ''
  uniprot_function: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin. {ECO:0000269|PubMed:3033643,
    ECO:0000269|PubMed:8262916}.
  uniprot_features: *id193
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id194
- organism: human
  gene: QPRT
  row_index: 17
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HDA exosome detection; not a functionally meaningful localization for a cytosolic enzyme, but retained as
    observed.
  uniprot_subcellular_location: ''
  uniprot_function: Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671,
    ECO:0000269|PubMed:9473669}.
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-197268
  - term: GO:1902494 catalytic complex
    qualifier: part_of
    evidence:
    - IDA PMID:17868694
- organism: human
  gene: RAB15
  row_index: 16
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This is a high-throughput detection that does not indicate functional localization. Detection in exosomes
    may reflect packaging of endosomal proteins into exosome vesicles during MVB formation, consistent with RAB15's endosomal
    localization, but does not represent a core functional localization.
  uniprot_subcellular_location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
  uniprot_function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an
    active GTP-bound form that is able to recruit to membranes different sets of d ...
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16195351
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005929 cilium
    qualifier: located_in
    evidence:
    - IDA PMID:17646400
  - term: GO:0010008 endosome membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16195351
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16195351
- organism: human
  gene: RAB7A
  row_index: 89
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HTP proteomics finding. RAB7A presence in exosomes is consistent with its role in MVB/late endosome biology.
  uniprot_subcellular_location: Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211};
    Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476,
    ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:28325809}; Peripheral
    membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791,
    ECO:0000269|PubMed:38538795}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305} ...
  uniprot_function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound
    form that is able to recruit to membranes different sets of downstream effect ...
  uniprot_features: &id195
  - LIPID
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id196
  - term: GO:0000421 autophagosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA PMID:34432599
  - term: GO:0005764 lysosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:18272684
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:15078902
  - term: GO:0005765 lysosomal membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:38538795
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-2213248
    - TAS Reactome:R-HSA-8854255
    - TAS Reactome:R-HSA-8854329
    - TAS Reactome:R-HSA-8877451
  - term: GO:0005770 late endosome
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:18272684
  - term: GO:0005770 late endosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IDA PMID:14617358
    - IDA PMID:15078902
    - IDA PMID:17010938
    - IEA GO_REF:0000107
    - TAS PMID:2115402
  - term: GO:0005811 lipid droplet
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
    - TAS Reactome:R-HSA-8877451
    - TAS Reactome:R-HSA-9636684
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0010008 endosome membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:19564404
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:22431521
    - IEA GO_REF:0000044
    - IMP PMID:26911690
  - term: GO:0030667 secretory granule membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798743
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-9636564
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030904 retromer complex
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:19531583
    - IDA PMID:24344282
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0031966 mitochondrial membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:19564404
  - term: GO:0033162 melanosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0034045 phagophore assembly site membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045335 phagocytic vesicle
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045335 phagocytic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:21255211
  - term: GO:0097208 alveolar lamellar body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098588 bounding membrane of organelle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0098830 presynaptic endosome
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: RAB7A
  row_index: 90
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HTP proteomics finding.
  uniprot_subcellular_location: Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211};
    Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476,
    ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:28325809}; Peripheral
    membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791,
    ECO:0000269|PubMed:38538795}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305} ...
  uniprot_function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound
    form that is able to recruit to membranes different sets of downstream effect ...
  uniprot_features: *id195
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id196
- organism: human
  gene: RAB7A
  row_index: 91
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HTP proteomics finding.
  uniprot_subcellular_location: Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211};
    Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476,
    ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:28325809}; Peripheral
    membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791,
    ECO:0000269|PubMed:38538795}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305} ...
  uniprot_function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound
    form that is able to recruit to membranes different sets of downstream effect ...
  uniprot_features: *id195
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id196
- organism: human
  gene: RAB9A
  row_index: 24
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput data annotation. While RAB9A may be detected in exosomes, this is not a core functional
    localization and may reflect contamination or incidental incorporation.
  uniprot_subcellular_location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic
    reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000305|PubMed:34793709}. Late endosome {ECO:0000269|PubMed:16176980,
    ECO:0000269|PubMed:34793709}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic
    side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:34793709}.
    Melanosome {ECO:0000250|UniProtKB:Q9R0M6}. Note=Colocalizes with OSBPL1A at the late endosome (Pub ...
  uniprot_function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound
    form that is able to recruit to membranes different sets of downstream effect ...
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:15078902
  - term: GO:0005770 late endosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IDA PMID:15078902
    - IEA GO_REF:0000044
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6814671
    - TAS Reactome:R-HSA-8876191
    - TAS Reactome:R-HSA-9706390
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030133 transport vesicle
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6814670
    - TAS Reactome:R-HSA-6814674
    - TAS Reactome:R-HSA-6814675
  - term: GO:0030659 cytoplasmic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0030670 phagocytic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031090 organelle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000043
  - term: GO:0032588 trans-Golgi network membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6814671
    - TAS Reactome:R-HSA-6814674
    - TAS Reactome:R-HSA-8876191
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0045335 phagocytic vesicle
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0045335 phagocytic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:21255211
    - IEA GO_REF:0000120
- organism: human
  gene: SCAMP2
  row_index: 12
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosome proteomics is consistent with SCAMP2's role in membrane trafficking and recycling.
    However, exosome localization is likely a secondary consequence of its primary function in endosomal/TGN trafficking rather
    than a core function. The study did not specifically focus on SCAMP2 function in exosomes.
  uniprot_subcellular_location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane
    protein {ECO:0000269|PubMed:15840657}. Recycling endosome membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane
    protein {ECO:0000269|PubMed:15840657}.
  uniprot_function: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
  uniprot_features:
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15840657
    - IEA GO_REF:0000002
  - term: GO:0032588 trans-Golgi network membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0032588 trans-Golgi network membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15840657
  - term: GO:0055038 recycling endosome membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0055038 recycling endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15840657
    - IEA GO_REF:0000044
- organism: human
  gene: SLC3A2
  row_index: 93
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization - exosomal presence common for membrane proteins.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135,
    ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744,
    ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562,
    ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}.
    Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269| ...
  uniprot_function: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers
    to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11),
    a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140,  ...
  uniprot_features: &id197
  - TRANSMEM
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id198
  - term: GO:0005765 lysosomal membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:11311135
    - IDA PMID:11557028
    - IDA PMID:12225859
    - IDA PMID:12270127
    - IDA PMID:23137377
    - IDA PMID:25998567
    - IDA PMID:28112518
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-352191
    - TAS Reactome:R-HSA-352232
    - TAS Reactome:R-HSA-375131
    - TAS Reactome:R-HSA-376200
    - TAS Reactome:R-HSA-378513
    - TAS Reactome:R-HSA-379415
    - TAS Reactome:R-HSA-379426
    - TAS Reactome:R-HSA-5660910
  - term: GO:0009925 basal plasma membrane
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:25063885
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - NAS PMID:3476959
  - term: GO:0016323 basolateral plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016323 basolateral plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:31791063
    - IEA GO_REF:0000044
  - term: GO:0016324 apical plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016324 apical plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:31791063
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0044225 apical pole of neuron
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0070161 anchoring junction
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:1990184 amino acid transport complex
    qualifier: part_of
    evidence:
    - IDA PMID:30867591
- organism: human
  gene: SLC3A2
  row_index: 96
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135,
    ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744,
    ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562,
    ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}.
    Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269| ...
  uniprot_function: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers
    to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11),
    a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140,  ...
  uniprot_features: *id197
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id198
- organism: human
  gene: SLC3A2
  row_index: 97
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135,
    ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744,
    ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562,
    ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}.
    Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269| ...
  uniprot_function: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers
    to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11),
    a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140,  ...
  uniprot_features: *id197
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id198
- organism: human
  gene: SLC3A2
  row_index: 100
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization.
  uniprot_subcellular_location: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135,
    ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744,
    ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562,
    ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}.
    Lysosome membrane {ECO:0000269|PubMed:25998567}. Melanosome {ECO:0000269| ...
  uniprot_function: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers
    to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11),
    a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140,  ...
  uniprot_features: *id197
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id198
- organism: human
  gene: SMO
  row_index: 76
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retained as non-core on the basis of high-throughput direct assay (PMID:23533145); it is secondary to SMO's
    sterol-regulated signaling activity at the plasma and primary-cilium membranes.
  uniprot_subcellular_location: Cell membrane {ECO:0000250|UniProtKB:P56726}; Multi-pass membrane protein {ECO:0000269|PubMed:27437577,
    ECO:0000269|PubMed:28513578, ECO:0000269|PubMed:31168089, ECO:0000269|PubMed:32929279}. Cell projection, cilium membrane
    {ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:28344083}; Multi-pass membrane protein {ECO:0000269|PubMed:27437577,
    ECO:0000269|PubMed:28513578, ECO:0000269|PubMed:31168089, ECO:0000269|PubMed:32929279}. Note=Translocates to primary cilium
    in response to hedgehog (DHH, IHH or SHH) morphogens (By similarity). Cilium localization is mediated via a beta-arrestin
    and KIF3A-d ...
  uniprot_function: G protein-coupled receptor, which transduces the smoothened signaling pathway (PubMed:19592253, PubMed:27437577,
    PubMed:28344083, PubMed:31168089, PubMed:32929279, PubMed:36202993). Activated by cholesterol in response to hedgehog
    (DHH, IHH or SHH) morphogens (PubMed:27437577, PubMed:28344083, PubMe ...
  uniprot_features: &id199
  - LIPID
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id200
  - term: GO:0005794 Golgi apparatus
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:11278759
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:19304771
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005901 caveola
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:11278759
  - term: GO:0005929 cilium
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005929 cilium
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:27727273
    - IDA PMID:32413283
    - ISS GO_REF:0000024
    - TAS PMID:21931618
  - term: GO:0005929 cilium
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0030425 dendrite
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0030666 endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5610763
    - TAS Reactome:R-HSA-5632668
  - term: GO:0060170 ciliary membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-5632668
    - TAS Reactome:R-HSA-5633040
  - term: GO:0097542 ciliary tip
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5610763
  - term: GO:0098804 non-motile cilium membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:22072986
    - IDA PMID:31168089
  - term: GO:0098804 non-motile cilium membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0120025 plasma membrane bounded cell projection
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
- organism: human
  gene: SMO
  row_index: 77
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Retained as non-core on the basis of high-throughput direct assay (PMID:19056867); it is secondary to SMO's
    sterol-regulated signaling activity at the plasma and primary-cilium membranes.
  uniprot_subcellular_location: Cell membrane {ECO:0000250|UniProtKB:P56726}; Multi-pass membrane protein {ECO:0000269|PubMed:27437577,
    ECO:0000269|PubMed:28513578, ECO:0000269|PubMed:31168089, ECO:0000269|PubMed:32929279}. Cell projection, cilium membrane
    {ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:28344083}; Multi-pass membrane protein {ECO:0000269|PubMed:27437577,
    ECO:0000269|PubMed:28513578, ECO:0000269|PubMed:31168089, ECO:0000269|PubMed:32929279}. Note=Translocates to primary cilium
    in response to hedgehog (DHH, IHH or SHH) morphogens (By similarity). Cilium localization is mediated via a beta-arrestin
    and KIF3A-d ...
  uniprot_function: G protein-coupled receptor, which transduces the smoothened signaling pathway (PubMed:19592253, PubMed:27437577,
    PubMed:28344083, PubMed:31168089, PubMed:32929279, PubMed:36202993). Activated by cholesterol in response to hedgehog
    (DHH, IHH or SHH) morphogens (PubMed:27437577, PubMed:28344083, PubMe ...
  uniprot_features: *id199
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id200
- organism: human
  gene: SMPD1
  row_index: 95
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HDA proteomic detection in exosomes; consistent with the secreted form but not indicative of a core exosomal
    function. Non-core.
  uniprot_subcellular_location: Lysosome {ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18815062, ECO:0000269|PubMed:20530211,
    ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:9660788}. Lipid droplet {ECO:0000269|PubMed:25339683}.
    Secreted {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:20530211,
    ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:22573858, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:8702487, ECO:0000269|PubMed:9030779,
    ECO:0000269|PubMed:9660788}. Note=The secreted form is induced in a time- and dose-dependent by IL1B a ...
  uniprot_function: Converts sphingomyelin to ceramide (PubMed:12563314, PubMed:1840600, PubMed:18815062, PubMed:25339683,
    PubMed:25920558, PubMed:27659707, PubMed:33163980). Exists as two enzymatic forms that arise from alternative trafficking
    of a single protein precursor, one that is targeted to the endolysosomal co ...
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:33163980
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:12563314
    - EXP PMID:9030779
    - IDA PMID:16787399
    - IDA PMID:17303575
    - IDA PMID:20530211
    - IDA PMID:20807762
    - IDA PMID:21098024
    - IDA PMID:22573858
    - IDA PMID:27659707
    - IDA PMID:8702487
    - IDA PMID:9660788
    - IEA GO_REF:0000120
  - term: GO:0005764 lysosome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:33163980
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:16787399
    - IDA PMID:18815062
    - IDA PMID:20530211
    - IDA PMID:20807762
    - IDA PMID:20956541
    - IDA PMID:21098024
    - IDA PMID:27659707
    - IDA PMID:9660788
    - IEA GO_REF:0000044
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:20956541
  - term: GO:0005811 lipid droplet
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:20956541
    - TAS Reactome:R-HSA-9769742
  - term: GO:0036019 endolysosome
    qualifier: located_in
    evidence:
    - IDA PMID:17303575
  - term: GO:0036021 endolysosome lumen
    qualifier: is_active_in
    evidence:
    - IC PMID:27498570
  - term: GO:0042599 lamellar body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0043202 lysosomal lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-1605797
- organism: human
  gene: SOD1
  row_index: 80
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A minor secreted/extracellular pool of SOD1 (including exosomes) exists but is peripheral to the cytosolic
    antioxidant function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:19741096}. Nucleus {ECO:0000269|PubMed:22496122}. Note=Predominantly
    cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. {ECO:0000269|PubMed:19741096}.
  uniprot_function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems
    (PubMed:24140062). Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying
    H2S and limiting the accumulation of reactive sulfur species (RSS) such a ...
  uniprot_features: &id201
  - LIPID
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id202
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:9453566
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-482772
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:1332049
    - IDA PMID:17504823
    - IDA PMID:22496122
    - IDA PMID:24023695
    - IDA PMID:9726962
    - IEA GO_REF:0000120
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:11527942
    - IDA PMID:1332049
    - IDA PMID:17077646
    - IDA PMID:17504823
    - IDA PMID:18809582
    - IDA PMID:19741096
    - IDA PMID:24023695
    - IDA PMID:24784232
    - IDA PMID:9726962
    - IEA GO_REF:0000120
  - term: GO:0005739 mitochondrion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA PMID:16790527
    - IDA PMID:19741096
  - term: GO:0005758 mitochondrial intermembrane space
    qualifier: is_active_in
    evidence:
    - IDA PMID:24026195
  - term: GO:0005758 mitochondrial intermembrane space
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-3777112
    - TAS Reactome:R-HSA-8950771
  - term: GO:0005759 mitochondrial matrix
    qualifier: located_in
    evidence:
    - NAS PMID:17008312
  - term: GO:0005764 lysosome
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005777 peroxisome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005777 peroxisome
    qualifier: located_in
    evidence:
    - IDA PMID:1332049
    - IEA GO_REF:0000107
    - ISS GO_REF:0000024
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - TAS PMID:24026195
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:16790527
    - TAS Reactome:R-HSA-3299691
    - TAS Reactome:R-HSA-3299753
    - TAS Reactome:R-HSA-3697860
    - TAS Reactome:R-HSA-482772
    - TAS Reactome:R-HSA-8951723
  - term: GO:0005886 plasma membrane
    qualifier: colocalizes_with
    evidence:
    - IDA PMID:17077646
    - IDA PMID:17324120
  - term: GO:0030141 secretory granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031045 dense core granule
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:17077646
  - term: GO:0032839 dendrite cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:17324120
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:17324120
    - IEA GO_REF:0000107
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IDA PMID:17324120
    - IEA GO_REF:0000107
  - term: GO:1902694 superoxide dismutase copper chaperone complex
    qualifier: part_of
    evidence:
    - IPI PMID:30735496
  - term: GO:1904115 axon cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
- organism: human
  gene: SOD1
  row_index: 85
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: A minor secreted/extracellular pool of SOD1 (including exosomes) exists but is peripheral to the cytosolic
    antioxidant function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:19741096}. Nucleus {ECO:0000269|PubMed:22496122}. Note=Predominantly
    cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. {ECO:0000269|PubMed:19741096}.
  uniprot_function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems
    (PubMed:24140062). Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying
    H2S and limiting the accumulation of reactive sulfur species (RSS) such a ...
  uniprot_features: *id201
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id202
- organism: human
  gene: SORL1
  row_index: 157
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic localization; not a core functional site.
  uniprot_subcellular_location: Golgi apparatus membrane {ECO:0000269|PubMed:11294867, ECO:0000269|PubMed:16174740, ECO:0000269|PubMed:17855360,
    ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:21994944}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus,
    trans-Golgi network membrane {ECO:0000269|PubMed:17646382, ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:23333276};
    Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:21385844, ECO:0000269|PubMed:23333276};
    Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16174740, ECO:0000 ...
  uniprot_function: Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along
    with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating
    its intracellular trafficking and processing into amyloidogenic-beta pepti ...
  uniprot_features:
  - SIGNAL
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000139 Golgi membrane
    qualifier: located_in
    evidence:
    - EXP PMID:11294867
    - EXP PMID:16174740
    - EXP PMID:17855360
    - EXP PMID:21385844
    - EXP PMID:21994944
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-8871506
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:11082041
    - EXP PMID:15053742
    - EXP PMID:16393139
    - EXP PMID:16531402
    - IDA PMID:14764453
    - IEA GO_REF:0000120
  - term: GO:0005641 nuclear envelope lumen
    qualifier: located_in
    evidence:
    - IDA PMID:17855360
    - IDA PMID:21989385
    - IEA GO_REF:0000107
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:16174740
    - IDA PMID:21385844
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IDA PMID:21385844
    - IDA PMID:24001769
    - IMP PMID:22621900
  - term: GO:0005771 multivesicular body
    qualifier: located_in
    evidence:
    - IDA PMID:21385844
    - IEA GO_REF:0000107
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:17855360
    - IDA PMID:21385844
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - EXP PMID:17855360
    - EXP PMID:21385844
    - IEA GO_REF:0000044
  - term: GO:0005794 Golgi apparatus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005794 Golgi apparatus
    qualifier: located_in
    evidence:
    - IDA PMID:11294867
    - IDA PMID:16174740
    - IDA PMID:21385844
    - IDA PMID:21994944
    - IEA GO_REF:0000044
  - term: GO:0005802 trans-Golgi network
    qualifier: located_in
    evidence:
    - IDA PMID:24001769
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000108
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:26858303
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:11294867
    - EXP PMID:14764453
    - EXP PMID:15053742
    - EXP PMID:17855360
    - EXP PMID:31138794
    - IDA PMID:21385844
    - IDA PMID:21994944
    - IEA GO_REF:0000044
    - TAS PMID:9157966
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:11294867
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:21385844
    - EXP PMID:23333276
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-8871494
    - TAS Reactome:R-HSA-8871506
  - term: GO:0016020 membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IDA PMID:14764453
    - IEA GO_REF:0000120
  - term: GO:0030658 transport vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0031901 early endosome membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:16174740
  - term: GO:0031901 early endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:17646382
    - EXP PMID:21385844
    - EXP PMID:31138794
    - IEA GO_REF:0000044
  - term: GO:0031985 Golgi cisterna
    qualifier: located_in
    evidence:
    - IDA PMID:17855360
  - term: GO:0032585 multivesicular body membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0043025 neuronal cell body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0055037 recycling endosome
    qualifier: located_in
    evidence:
    - IMP PMID:22621900
  - term: GO:0055038 recycling endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:17855360
    - EXP PMID:31138794
    - IEA GO_REF:0000044
  - term: GO:0097356 perinucleolar compartment
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: SPR
  row_index: 8
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection of SPR in exosomes represents a finding from high-throughput proteomics but does not indicate
    a primary functional localization. Many cytosolic proteins are detected in exosomes. This is not core to SPR function
    but may be retained as a non-core observation.
  uniprot_subcellular_location: Cytoplasm.
  uniprot_function: Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  uniprot_features: &id203 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id204
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-1475414
    - TAS Reactome:R-HSA-1497853
    - TAS Reactome:R-HSA-1497869
- organism: human
  gene: SPR
  row_index: 9
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Similar to the other exosome annotation - detection in a proteomics survey does not indicate primary functional
    localization. Can be retained as non-core observation.
  uniprot_subcellular_location: Cytoplasm.
  uniprot_function: Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  uniprot_features: *id203
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id204
- organism: human
  gene: SQSTM1
  row_index: 248
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Likely incidental detection in secreted vesicles; non-core localization.
  uniprot_subcellular_location: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16286508,
    ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:37802024}. Preautophagosomal structure {ECO:0000269|PubMed:34471133}.
    Cytoplasm, cytosol {ECO:0000269|PubMed:11786419, ECO:0000269|PubMed:11981755, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20357094,
    ECO:0000269|PubMed:21923101, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29507397,
    ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:3 ...
  uniprot_function: Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated
    proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874,
    PubMed:22622177, PubMed:24128730, PubMed:28404643, P ...
  uniprot_features:
  - LIPID
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0000407 phagophore assembly site
    qualifier: located_in
    evidence:
    - EXP PMID:34471133
    - IEA GO_REF:0000120
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:10708586
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-204947
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IC PMID:31281713
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:20168092
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - EXP PMID:9566925
    - IEA GO_REF:0000044
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - EXP PMID:12471037
    - EXP PMID:9566925
    - IEA GO_REF:0000044
  - term: GO:0005776 autophagosome
    qualifier: is_active_in
    evidence:
    - IDA PMID:30612879
    - IDA PMID:37802024
  - term: GO:0005776 autophagosome
    qualifier: located_in
    evidence:
    - IDA PMID:17580304
    - IDA PMID:19640926
    - IDA PMID:20168092
    - IDA PMID:22948227
    - IDA PMID:24954904
    - IDA PMID:25365221
    - IEA GO_REF:0000120
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - EXP PMID:22178386
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IDA PMID:29343546
    - IDA PMID:29507397
    - IDA PMID:37306101
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IEA GO_REF:0000044
    - TAS PMID:8650207
    - TAS Reactome:R-HSA-193641
    - TAS Reactome:R-HSA-193684
    - TAS Reactome:R-HSA-193694
    - TAS Reactome:R-HSA-193703
    - TAS Reactome:R-HSA-193705
    - TAS Reactome:R-HSA-204947
    - TAS Reactome:R-HSA-205008
    - TAS Reactome:R-HSA-209566
    - TAS Reactome:R-HSA-507719
    - TAS Reactome:R-HSA-5205649
    - TAS Reactome:R-HSA-5205663
    - TAS Reactome:R-HSA-5205673
    - TAS Reactome:R-HSA-9664855
    - TAS Reactome:R-HSA-9664880
    - TAS Reactome:R-HSA-9664881
    - TAS Reactome:R-HSA-9664892
    - TAS Reactome:R-HSA-9759154
    - TAS Reactome:R-HSA-9759157
    - TAS Reactome:R-HSA-9759158
    - TAS Reactome:R-HSA-9759169
    - TAS Reactome:R-HSA-9759172
    - TAS Reactome:R-HSA-9761900
    - TAS Reactome:R-HSA-9766532
    - TAS Reactome:R-HSA-9766645
    - TAS Reactome:R-HSA-9766656
    - TAS Reactome:R-HSA-9766677
    - TAS Reactome:R-HSA-9766687
  - term: GO:0016234 inclusion body
    qualifier: located_in
    evidence:
    - IDA PMID:20168092
    - IEA GO_REF:0000117
  - term: GO:0016235 aggresome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0016235 aggresome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0016605 PML body
    qualifier: located_in
    evidence:
    - IDA PMID:20168092
    - IEA GO_REF:0000044
  - term: GO:0030017 sarcomere
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0036464 cytoplasmic ribonucleoprotein granule
    qualifier: located_in
    evidence:
    - IDA PMID:20357094
  - term: GO:0043232 intracellular membraneless organelle
    qualifier: is_active_in
    evidence:
    - IDA PMID:22017874
    - IDA PMID:29343546
    - IDA PMID:29507397
    - IDA PMID:31857589
    - IDA PMID:37802024
  - term: GO:0044753 amphisome
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0044753 amphisome
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
  - term: GO:0044754 autolysosome
    qualifier: located_in
    evidence:
    - IDA PMID:19640926
    - IEA GO_REF:0000107
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0097225 sperm midpiece
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0097413 Lewy body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
- organism: human
  gene: SRC
  row_index: 522
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: SRC was detected in exosome proteomics; this reflects packaging of a membrane-associated protein rather
    than a functional location.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion
    inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}.
    Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}.
    Cell junction {ECO:0000269|PubMed:22294297}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373).
    Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocal ...
  uniprot_function: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes
    of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine
    kinases, G protein-coupled receptors as well as cytokine receptors (PubM ...
  uniprot_features: &id205
  - LIPID
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id206
  - term: GO:0002102 podosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:7853507
    - IEA GO_REF:0000120
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16441665
    - IEA GO_REF:0000107
  - term: GO:0005739 mitochondrion
    qualifier: located_in
    evidence:
    - IDA PMID:19767770
    - IEA GO_REF:0000107
  - term: GO:0005743 mitochondrial inner membrane
    qualifier: located_in
    evidence:
    - IDA PMID:12615910
    - IEA GO_REF:0000120
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA PMID:20605918
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IDA PMID:20605918
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:19767770
    - IEA GO_REF:0000117
    - TAS Reactome:R-HSA-1433418
    - TAS Reactome:R-HSA-1433428
    - TAS Reactome:R-HSA-1433451
    - TAS Reactome:R-HSA-1433454
    - TAS Reactome:R-HSA-1433456
    - TAS Reactome:R-HSA-1433488
    - TAS Reactome:R-HSA-1433506
    - TAS Reactome:R-HSA-1433514
    - TAS Reactome:R-HSA-1433542
    - TAS Reactome:R-HSA-1470009
    - TAS Reactome:R-HSA-1470010
    - TAS Reactome:R-HSA-1470012
    - TAS Reactome:R-HSA-1472121
    - TAS Reactome:R-HSA-1562641
    - TAS Reactome:R-HSA-191654
    - TAS Reactome:R-HSA-2029459
    - TAS Reactome:R-HSA-205234
    - TAS Reactome:R-HSA-205238
    - TAS Reactome:R-HSA-205244
    - TAS Reactome:R-HSA-205319
    - TAS Reactome:R-HSA-210291
    - TAS Reactome:R-HSA-377640
    - TAS Reactome:R-HSA-388829
    - TAS Reactome:R-HSA-388831
    - TAS Reactome:R-HSA-388833
    - TAS Reactome:R-HSA-3928604
    - TAS Reactome:R-HSA-3928607
    - TAS Reactome:R-HSA-3928614
    - TAS Reactome:R-HSA-3928615
    - TAS Reactome:R-HSA-3928625
    - TAS Reactome:R-HSA-3928627
    - TAS Reactome:R-HSA-3928628
    - TAS Reactome:R-HSA-3928631
    - TAS Reactome:R-HSA-3928633
    - TAS Reactome:R-HSA-3928639
    - TAS Reactome:R-HSA-3928640
    - TAS Reactome:R-HSA-3928641
    - TAS Reactome:R-HSA-3928642
    - TAS Reactome:R-HSA-3928645
    - TAS Reactome:R-HSA-3928651
    - TAS Reactome:R-HSA-4093327
    - TAS Reactome:R-HSA-4093336
    - TAS Reactome:R-HSA-418158
    - TAS Reactome:R-HSA-418163
    - TAS Reactome:R-HSA-418170
    - TAS Reactome:R-HSA-418176
    - TAS Reactome:R-HSA-418200
    - TAS Reactome:R-HSA-418662
    - TAS Reactome:R-HSA-4420121
    - TAS Reactome:R-HSA-4420128
    - TAS Reactome:R-HSA-4420140
    - TAS Reactome:R-HSA-4420206
    - TAS Reactome:R-HSA-443418
    - TAS Reactome:R-HSA-443439
    - TAS Reactome:R-HSA-445084
    - TAS Reactome:R-HSA-5218640
    - TAS Reactome:R-HSA-5218643
    - TAS Reactome:R-HSA-5218645
    - TAS Reactome:R-HSA-5218809
    - TAS Reactome:R-HSA-5218811
    - TAS Reactome:R-HSA-5218819
    - TAS Reactome:R-HSA-5218820
    - TAS Reactome:R-HSA-5218822
    - TAS Reactome:R-HSA-5218826
    - TAS Reactome:R-HSA-5218830
    - TAS Reactome:R-HSA-5218838
    - TAS Reactome:R-HSA-5218839
    - TAS Reactome:R-HSA-5218851
    - TAS Reactome:R-HSA-5357429
    - TAS Reactome:R-HSA-5357432
    - TAS Reactome:R-HSA-5357479
    - TAS Reactome:R-HSA-5666104
    - TAS Reactome:R-HSA-8855747
    - TAS Reactome:R-HSA-8948143
    - TAS Reactome:R-HSA-8964242
    - TAS Reactome:R-HSA-8964252
    - TAS Reactome:R-HSA-8964278
    - TAS Reactome:R-HSA-8964287
    - TAS Reactome:R-HSA-8964329
    - TAS Reactome:R-HSA-9664261
    - TAS Reactome:R-HSA-9664275
    - TAS Reactome:R-HSA-9670412
    - TAS Reactome:R-HSA-9670413
    - TAS Reactome:R-HSA-9670414
    - TAS Reactome:R-HSA-9670416
    - TAS Reactome:R-HSA-9670417
    - TAS Reactome:R-HSA-9670418
    - TAS Reactome:R-HSA-9670426
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005884 actin filament
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:7525268
    - IDA GO_REF:0000052
    - IDA PMID:20605918
    - IEA GO_REF:0000120
    - TAS Reactome:R-HSA-112333
    - TAS Reactome:R-HSA-1295609
    - TAS Reactome:R-HSA-177923
    - TAS Reactome:R-HSA-177937
    - TAS Reactome:R-HSA-186819
    - TAS Reactome:R-HSA-191636
    - TAS Reactome:R-HSA-191654
    - TAS Reactome:R-HSA-191656
    - TAS Reactome:R-HSA-1963586
    - TAS Reactome:R-HSA-2316434
    - TAS Reactome:R-HSA-2400009
    - TAS Reactome:R-HSA-354066
    - TAS Reactome:R-HSA-354073
    - TAS Reactome:R-HSA-354077
    - TAS Reactome:R-HSA-354087
    - TAS Reactome:R-HSA-354124
    - TAS Reactome:R-HSA-354149
    - TAS Reactome:R-HSA-354165
    - TAS Reactome:R-HSA-372693
    - TAS Reactome:R-HSA-372697
    - TAS Reactome:R-HSA-372705
    - TAS Reactome:R-HSA-373716
    - TAS Reactome:R-HSA-374701
    - TAS Reactome:R-HSA-377640
    - TAS Reactome:R-HSA-377641
    - TAS Reactome:R-HSA-377643
    - TAS Reactome:R-HSA-377644
    - TAS Reactome:R-HSA-380780
    - TAS Reactome:R-HSA-418850
    - TAS Reactome:R-HSA-418856
    - TAS Reactome:R-HSA-418858
    - TAS Reactome:R-HSA-418868
    - TAS Reactome:R-HSA-418874
    - TAS Reactome:R-HSA-429415
    - TAS Reactome:R-HSA-429441
    - TAS Reactome:R-HSA-432096
    - TAS Reactome:R-HSA-443905
    - TAS Reactome:R-HSA-443910
    - TAS Reactome:R-HSA-5607750
    - TAS Reactome:R-HSA-8874080
    - TAS Reactome:R-HSA-8874082
    - TAS Reactome:R-HSA-8874083
    - TAS Reactome:R-HSA-8876948
    - TAS Reactome:R-HSA-8937792
    - TAS Reactome:R-HSA-8937807
    - TAS Reactome:R-HSA-9021596
    - TAS Reactome:R-HSA-9021609
    - TAS Reactome:R-HSA-9021660
    - TAS Reactome:R-HSA-9603419
    - TAS Reactome:R-HSA-9603420
    - TAS Reactome:R-HSA-9612219
    - TAS Reactome:R-HSA-9632412
    - TAS Reactome:R-HSA-9934751
    - TAS Reactome:R-HSA-9958889
    - TAS Reactome:R-HSA-9958892
  - term: GO:0005901 caveola
    qualifier: located_in
    evidence:
    - IDA PMID:17848177
    - IEA GO_REF:0000120
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IDA PMID:22294297
  - term: GO:0005925 focal adhesion
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0030054 cell junction
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0032587 ruffle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0045121 membrane raft
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:19307596
    - IEA GO_REF:0000120
  - term: GO:0070161 anchoring junction
    qualifier: located_in
    evidence:
    - EXP PMID:22294297
    - IEA GO_REF:0000044
- organism: human
  gene: SRC
  row_index: 523
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: SRC was detected in exosome proteomics; this reflects packaging of a membrane-associated protein rather
    than a functional location.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion
    inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}.
    Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}.
    Cell junction {ECO:0000269|PubMed:22294297}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373).
    Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocal ...
  uniprot_function: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes
    of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine
    kinases, G protein-coupled receptors as well as cytokine receptors (PubM ...
  uniprot_features: *id205
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id206
- organism: human
  gene: SYPL1
  row_index: 7
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The proteomic detection is plausible for a broadly expressed vesicle membrane protein, but exosomal recovery
    is context-specific and does not by itself identify SYPL1's evolved core role. The main cached article does not expose
    the SYPL1 peptide row.
  uniprot_subcellular_location: Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Melanosome
    {ECO:0000269|PubMed:17081065}. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in
    melanosome fractions from stage I to stage IV. {ECO:0000250}.
  uniprot_function: ''
  uniprot_features:
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - TAS PMID:8034131
  - term: GO:0008021 synaptic vesicle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - TAS PMID:1730063
  - term: GO:0030659 cytoplasmic vesicle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0030672 synaptic vesicle membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: TALDO1
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: TALDO1 is a cytosolic metabolic enzyme frequently co-purified in exosome proteomes; this HDA detection is
    real but does not indicate a functional extracellular-exosome localization or role, so it is retained as non-core.
  uniprot_subcellular_location: '[Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q93092}. Cytoplasm {ECO:0000250|UniProtKB:Q93092}.
    Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent
    manner. Exported into the cytoplasm by CRM1. {ECO:0000250|UniProtKB:Q93092}. [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q93092}.
    Note=Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer. {ECO:0000250|UniProtKB:Q93092}.'
  uniprot_function: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes
    the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and
    beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts  ...
  uniprot_features: &id207 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id208
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS PMID:16130169
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:18498245
    - TAS Reactome:R-HSA-163764
    - TAS Reactome:R-HSA-5659989
    - TAS Reactome:R-HSA-5659998
    - TAS Reactome:R-HSA-71334
    - TAS Reactome:R-HSA-8950367
    - TAS Reactome:R-HSA-9761858
- organism: human
  gene: TALDO1
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: As with the prostatic-secretion exosome dataset, this reflects proteomic co-purification of a cytosolic
    enzyme in exosome preparations rather than a functional exosomal role; retained as non-core.
  uniprot_subcellular_location: '[Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q93092}. Cytoplasm {ECO:0000250|UniProtKB:Q93092}.
    Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent
    manner. Exported into the cytoplasm by CRM1. {ECO:0000250|UniProtKB:Q93092}. [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q93092}.
    Note=Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer. {ECO:0000250|UniProtKB:Q93092}.'
  uniprot_function: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes
    the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and
    beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts  ...
  uniprot_features: *id207
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id208
- organism: human
  gene: TFRC
  row_index: 129
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Genuine but secondary localization reflecting exosomal/EV sorting of TfR1; not the core membrane-receptor
    function. Retained as non-core.
  uniprot_subcellular_location: 'Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}.
    Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to
    stage IV. {ECO:0000269|PubMed:17081065}. [Transferrin receptor protein 1, serum form]: Secreted {ECO:0000269|PubMed:17081065}.'
  uniprot_function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor
    into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor
    complex is then recycled to the cell surface with a return to neutral pH a ...
  uniprot_features: &id209
  - LIPID
  - TRANSMEM
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id210
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:1871153
    - IEA GO_REF:0000044
  - term: GO:0005615 extracellular space
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:14612438
    - IEA GO_REF:0000107
    - TAS PMID:8394993
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:26642240
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:23137377
    - IEA GO_REF:0000120
    - IGI PMID:18353247
    - TAS PMID:6090955
    - TAS Reactome:R-HSA-5691154
    - TAS Reactome:R-HSA-8866277
    - TAS Reactome:R-HSA-8867754
    - TAS Reactome:R-HSA-8867756
    - TAS Reactome:R-HSA-8868071
    - TAS Reactome:R-HSA-8868072
    - TAS Reactome:R-HSA-8868230
    - TAS Reactome:R-HSA-8868236
    - TAS Reactome:R-HSA-8868648
    - TAS Reactome:R-HSA-8868651
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-917807
    - TAS Reactome:R-HSA-917814
    - TAS Reactome:R-HSA-917839
    - TAS Reactome:R-HSA-917987
  - term: GO:0005905 clathrin-coated pit
    qualifier: located_in
    evidence:
    - IDA PMID:12857860
    - IEA GO_REF:0000107
  - term: GO:0009897 external side of plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0009897 external side of plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
    - IGI PMID:18353247
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IDA PMID:7556058
    - IEA GO_REF:0000120
    - ISS PMID:18619525
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:16380373
    - TAS Reactome:R-HSA-917807
    - TAS Reactome:R-HSA-917814
    - TAS Reactome:R-HSA-917835
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
    - NAS PMID:1871153
  - term: GO:0016323 basolateral plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:9990067
  - term: GO:0030669 clathrin-coated endocytic vesicle membrane
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-8868658
    - TAS Reactome:R-HSA-8868659
    - TAS Reactome:R-HSA-8868660
    - TAS Reactome:R-HSA-8868661
    - TAS Reactome:R-HSA-8869438
    - TAS Reactome:R-HSA-8871193
    - TAS Reactome:R-HSA-8871194
  - term: GO:0031410 cytoplasmic vesicle
    qualifier: located_in
    evidence:
    - IDA PMID:15229288
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16380373
    - IEA GO_REF:0000107
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: part_of
    evidence:
    - IDA PMID:20202662
  - term: GO:0055037 recycling endosome
    qualifier: located_in
    evidence:
    - IDA PMID:22456507
    - IDA PMID:24561039
    - IEA GO_REF:0000120
  - term: GO:0055038 recycling endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098794 postsynapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098944 postsynaptic recycling endosome membrane
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1990712 HFE-transferrin receptor complex
    qualifier: part_of
    evidence:
    - IDA PMID:9465039
    - IDA PMID:9546397
    - IDA PMID:9990067
    - IEA GO_REF:0000107
- organism: human
  gene: TFRC
  row_index: 138
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization reflecting vesicular/soluble release of TfR1 into blood; not the core membrane-receptor
    function. Retained as non-core.
  uniprot_subcellular_location: 'Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}.
    Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to
    stage IV. {ECO:0000269|PubMed:17081065}. [Transferrin receptor protein 1, serum form]: Secreted {ECO:0000269|PubMed:17081065}.'
  uniprot_function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor
    into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor
    complex is then recycled to the cell surface with a return to neutral pH a ...
  uniprot_features: *id209
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id210
- organism: human
  gene: TFRC
  row_index: 141
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Secondary localization reflecting exosomal sorting of TfR1; not the core membrane-receptor function. Retained
    as non-core.
  uniprot_subcellular_location: 'Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}.
    Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to
    stage IV. {ECO:0000269|PubMed:17081065}. [Transferrin receptor protein 1, serum form]: Secreted {ECO:0000269|PubMed:17081065}.'
  uniprot_function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor
    into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor
    complex is then recycled to the cell surface with a return to neutral pH a ...
  uniprot_features: *id209
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id210
- organism: human
  gene: TLN1
  row_index: 80
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant cytoskeletal proteins are commonly detected in exosome preparations; this reflects cargo, not a
    talin function.
  uniprot_subcellular_location: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
    Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized
    preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
  uniprot_function: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts.
    Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co- organize the assembly
    of cortical microtubule stabilizing complexes (CMSCs) positioned to control  ...
  uniprot_features: &id211 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id212
  - term: GO:0001726 ruffle
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
    - ISS GO_REF:0000024
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-482772
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-1791137
    - TAS Reactome:R-HSA-354066
    - TAS Reactome:R-HSA-354073
    - TAS Reactome:R-HSA-354077
    - TAS Reactome:R-HSA-354087
    - TAS Reactome:R-HSA-354097
    - TAS Reactome:R-HSA-354124
    - TAS Reactome:R-HSA-354149
    - TAS Reactome:R-HSA-354165
    - TAS Reactome:R-HSA-372693
    - TAS Reactome:R-HSA-372697
    - TAS Reactome:R-HSA-372705
    - TAS Reactome:R-HSA-377640
    - TAS Reactome:R-HSA-377641
    - TAS Reactome:R-HSA-377643
    - TAS Reactome:R-HSA-377644
    - TAS Reactome:R-HSA-399936
    - TAS Reactome:R-HSA-429415
    - TAS Reactome:R-HSA-429441
    - TAS Reactome:R-HSA-432096
    - TAS Reactome:R-HSA-443905
    - TAS Reactome:R-HSA-443910
    - TAS Reactome:R-HSA-445699
    - TAS Reactome:R-HSA-445700
    - TAS Reactome:R-HSA-445704
    - TAS Reactome:R-HSA-445705
    - TAS Reactome:R-HSA-482772
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005912 adherens junction
    qualifier: located_in
    evidence:
    - IMP PMID:26923917
  - term: GO:0005925 focal adhesion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005925 focal adhesion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:15070891
    - IEA GO_REF:0000120
    - IMP PMID:26923917
    - ISS GO_REF:0000024
  - term: GO:0009986 cell surface
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0032587 ruffle membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0034451 centriolar satellite
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
- organism: human
  gene: TLN1
  row_index: 81
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant cytoskeletal proteins are commonly detected in exosome preparations; this reflects cargo, not a
    talin function.
  uniprot_subcellular_location: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
    Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized
    preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
  uniprot_function: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts.
    Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co- organize the assembly
    of cortical microtubule stabilizing complexes (CMSCs) positioned to control  ...
  uniprot_features: *id211
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id212
- organism: human
  gene: TLN1
  row_index: 82
  term: GO:0070062 extracellular exosome
  reference: PMID:21362503
  reference_title: Protein profile of exosomes from trabecular meshwork cells.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant cytoskeletal proteins are commonly detected in exosome preparations; this reflects cargo, not a
    talin function.
  uniprot_subcellular_location: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
    Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized
    preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
  uniprot_function: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts.
    Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co- organize the assembly
    of cortical microtubule stabilizing complexes (CMSCs) positioned to control  ...
  uniprot_features: *id211
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id212
- organism: human
  gene: TLN1
  row_index: 83
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant cytoskeletal proteins are commonly detected in exosome preparations; this reflects cargo, not a
    talin function.
  uniprot_subcellular_location: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
    Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized
    preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
  uniprot_function: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts.
    Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co- organize the assembly
    of cortical microtubule stabilizing complexes (CMSCs) positioned to control  ...
  uniprot_features: *id211
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id212
- organism: human
  gene: TNFAIP3
  row_index: 95
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection in exosomes by mass spectrometry may reflect passive incorporation rather than functional localization.
    Not a core functional location.
  uniprot_subcellular_location: 'Cytoplasm. Nucleus. Lysosome. [A20p50]: Cytoplasm.'
  uniprot_function: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in
    immune and inflammatory responses signaled by cytokines, such as TNF and IL-1 beta, or pathogens via Toll-like receptors
    (TLRs) through terminating NF-kappa-B activity. Essential component of a ub ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:11463333
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000120
  - term: GO:0005764 lysosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-5357845
    - TAS Reactome:R-HSA-5690827
    - TAS Reactome:R-HSA-5690845
    - TAS Reactome:R-HSA-5690856
    - TAS Reactome:R-HSA-5690870
    - TAS Reactome:R-HSA-5693055
    - TAS Reactome:R-HSA-5693108
    - TAS Reactome:R-HSA-688136
    - TAS Reactome:R-HSA-8869506
    - TAS Reactome:R-HSA-937337
- organism: human
  gene: TNFSF10
  row_index: 59
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: The exosome localization is plausible but peripheral to the receptor-ligand activity of TNFSF10.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:14609566}; Single-pass type II membrane protein {ECO:0000305}.
    Secreted {ECO:0000269|PubMed:14609566}. Note=Exists both as membrane-bound and soluble form. {ECO:0000269|PubMed:14609566}.
  uniprot_function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and
    possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by
    binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF1 ...
  uniprot_features:
  - TRANSMEM
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:21146232
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:14609566
    - IEA GO_REF:0000044
    - TAS Reactome:R-HSA-139952
    - TAS Reactome:R-HSA-141139
    - TAS Reactome:R-HSA-141156
    - TAS Reactome:R-HSA-141316
    - TAS Reactome:R-HSA-3371359
    - TAS Reactome:R-HSA-3465429
    - TAS Reactome:R-HSA-3465448
    - TAS Reactome:R-HSA-5675456
    - TAS Reactome:R-HSA-75146
    - TAS Reactome:R-HSA-75187
    - TAS Reactome:R-HSA-75238
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - EXP PMID:14609566
    - IEA GO_REF:0000044
    - TAS PMID:8663110
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
- organism: human
  gene: TPI1
  row_index: 28
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Valid high-throughput proteomic detection, but exosomal localization is a secondary/moonlighting or passive-packaging
    observation rather than where TPI1 performs its core glycolytic function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
  uniprot_function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion
    between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.
    It is also responsible for the non-negligible pro ...
  uniprot_features: &id213 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id214
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-70454
    - TAS Reactome:R-HSA-70481
- organism: human
  gene: TPI1
  row_index: 33
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Valid proteomic detection in exosomes, but this localization is secondary and does not reflect where TPI1
    performs its core glycolytic function.
  uniprot_subcellular_location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
  uniprot_function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion
    between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.
    It is also responsible for the non-negligible pro ...
  uniprot_features: *id213
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id214
- organism: human
  gene: TPM3
  row_index: 26
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Detection of TPM3 in extracellular exosomes represents exosomal cargo packaging rather than a site of TPM3
    function. Cytoskeletal proteins are commonly found in exosome proteomes. This is a valid observation but does not represent
    a core functional localization for TPM3, which primarily functions on actin filaments in the cytoskeleton.
  uniprot_subcellular_location: Cytoplasm, cytoskeleton {ECO:0000305}.
  uniprot_function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the
    troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction
    is regulated by interaction with caldesmon. In non-muscle cells is implica ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0001725 stress fiber
    qualifier: located_in
    evidence:
    - IDA PMID:16236705
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-390593
    - TAS Reactome:R-HSA-390595
    - TAS Reactome:R-HSA-390597
    - TAS Reactome:R-HSA-390598
    - TAS Reactome:R-HSA-445699
    - TAS Reactome:R-HSA-445700
    - TAS Reactome:R-HSA-445704
    - TAS Reactome:R-HSA-445705
    - TAS Reactome:R-HSA-9700179
    - TAS Reactome:R-HSA-9700181
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - NAS PMID:3418707
    - TAS PMID:16130169
  - term: GO:0005862 muscle thin filament tropomyosin
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000117
    - TAS PMID:3018581
  - term: GO:0005884 actin filament
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
- organism: human
  gene: TSG101
  row_index: 91
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: TSG101 is commonly detected in exosome preparations and regulates exosomal release, but this is secondary
    to its ESCRT-I membrane-remodeling role.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17853893}. Early endosome membrane {ECO:0000269|PubMed:23166352};
    Peripheral membrane protein {ECO:0000305|PubMed:23166352}; Cytoplasmic side {ECO:0000305|PubMed:23166352}. Late endosome
    membrane {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17229889}; Peripheral membrane protein. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome {ECO:0000269|PubMed:17853893}. Midbody, Midbody ring {ECO:0000269|PubMed:17556548,
    ECO:0000269|PubMed:17853893}. Nucleus {ECO:0000269|PubMed:17229889}. Note=Mainly cytoplasmic. Membrane- associated when
    active and solu ...
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
    cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates
    the association between the ESCRT-0 and ESCRT-I complex. Required for co ...
  uniprot_features: &id215 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id216
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:20654576
    - IDA PMID:21757351
    - IDA PMID:22232651
    - IEA GO_REF:0000117
    - IPI PMID:18005716
    - IPI PMID:21757351
    - IPI PMID:32424346
    - TAS PMID:20588296
    - TAS PMID:21118109
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:17229889
    - IEA GO_REF:0000044
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - EXP PMID:17853893
    - IDA PMID:18077552
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:17940959
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IDA PMID:11916981
    - IDA PMID:17229889
  - term: GO:0005770 late endosome
    qualifier: located_in
    evidence:
    - IMP PMID:15126635
  - term: GO:0005771 multivesicular body
    qualifier: located_in
    evidence:
    - TAS PMID:15611048
  - term: GO:0005813 centrosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17940959
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32424346
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0031901 early endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:23166352
    - IEA GO_REF:0000044
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - EXP PMID:11916981
    - EXP PMID:17229889
    - IEA GO_REF:0000044
  - term: GO:0070062 extracellular exosome
    qualifier: located_in
    evidence:
    - IDA PMID:15326289
    - IDA PMID:16501490
    - IDA PMID:23092844
    - IEA GO_REF:0000107
  - term: GO:0090543 Flemming body
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: TSG101
  row_index: 100
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: TSG101 is commonly detected in exosome preparations and regulates exosomal release, but this is secondary
    to its ESCRT-I membrane-remodeling role.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17853893}. Early endosome membrane {ECO:0000269|PubMed:23166352};
    Peripheral membrane protein {ECO:0000305|PubMed:23166352}; Cytoplasmic side {ECO:0000305|PubMed:23166352}. Late endosome
    membrane {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17229889}; Peripheral membrane protein. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome {ECO:0000269|PubMed:17853893}. Midbody, Midbody ring {ECO:0000269|PubMed:17556548,
    ECO:0000269|PubMed:17853893}. Nucleus {ECO:0000269|PubMed:17229889}. Note=Mainly cytoplasmic. Membrane- associated when
    active and solu ...
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
    cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates
    the association between the ESCRT-0 and ESCRT-I complex. Required for co ...
  uniprot_features: *id215
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id216
- organism: human
  gene: TXN
  row_index: 57
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput proteomic identification of Trx1 in exosomes. While consistent with extracellular localization,
    this is likely a secondary observation rather than a core function.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054,
    ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus
    after phorbol 12- myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated
    cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted
    by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|P
    ...
  uniprot_function: Participates in various redox reactions through the reversible oxidation of its active center dithiol
    to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490).
    Plays a role in the reversible S- nitrosylation of cysteine residues in target p ...
  uniprot_features: &id217 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id218
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - IDA PMID:1332947
    - IEA GO_REF:0000044
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:9108029
    - IEA GO_REF:0000044
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-NUL-9617742
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:9108029
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-111751
    - TAS Reactome:R-HSA-111804
    - TAS Reactome:R-HSA-1250264
    - TAS Reactome:R-HSA-1250280
    - TAS Reactome:R-HSA-3225851
    - TAS Reactome:R-HSA-3341343
    - TAS Reactome:R-HSA-3697882
    - TAS Reactome:R-HSA-5676917
    - TAS Reactome:R-HSA-5676940
    - TAS Reactome:R-HSA-73646
    - TAS Reactome:R-HSA-9796045
- organism: human
  gene: TXN
  row_index: 60
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with Trx1 secretion, but exosomal localization is not a core function.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054,
    ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus
    after phorbol 12- myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated
    cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted
    by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|P
    ...
  uniprot_function: Participates in various redox reactions through the reversible oxidation of its active center dithiol
    to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490).
    Plays a role in the reversible S- nitrosylation of cysteine residues in target p ...
  uniprot_features: *id217
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id218
- organism: human
  gene: TXN
  row_index: 61
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Consistent with extracellular presence of Trx1 but not a core function.
  uniprot_subcellular_location: Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054,
    ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus
    after phorbol 12- myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated
    cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted
    by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|P
    ...
  uniprot_function: Participates in various redox reactions through the reversible oxidation of its active center dithiol
    to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490).
    Plays a role in the reversible S- nitrosylation of cysteine residues in target p ...
  uniprot_features: *id217
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id218
- organism: human
  gene: TXNDC16
  row_index: 6
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Proteomic detection in exosomes that was not reproduced in a subsequent study (PMID:25122923); uncertain
    and non-core, but not removed on weak grounds.
  uniprot_subcellular_location: Secreted {ECO:0000269|PubMed:25122923}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:21359175,
    ECO:0000269|PubMed:25122923}.
  uniprot_function: ''
  uniprot_features:
  - SIGNAL
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - EXP PMID:25122923
    - IEA GO_REF:0000044
  - term: GO:0005788 endoplasmic reticulum lumen
    qualifier: located_in
    evidence:
    - EXP PMID:25122923
    - IDA PMID:21359175
    - IEA GO_REF:0000044
- organism: human
  gene: UPB1
  row_index: 20
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: This is a large-scale mass-spectrometry detection in urinary exosomes, not evidence for the functional localization
    of the enzyme, which is cytosolic. Retained as non-core to reflect the proteomic observation without implying an extracellular
    functional role.
  uniprot_subcellular_location: Cytoplasm.
  uniprot_function: Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine
    (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10415095, PubMed:10542323, PubMed:11508704,
    PubMed:22525402, PubMed:24526388, PubMed:29976570). Likewise, c ...
  uniprot_features: []
  gene_vesicle_rows: 1
  gene_vesicle_references: 1
  leads:
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-73591
    - TAS Reactome:R-HSA-73620
- organism: human
  gene: VCL
  row_index: 98
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in exosomes; not a functional location.
  uniprot_subcellular_location: Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003};
    Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Cell
    membrane, sarcolemma {ECO:0000250|UniProtKB:Q64727}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64727}; Cytoplasmic
    side {ECO:0000250|UniProtKB:Q64727}. Cell projection, podosome {ECO:0000250|UniProtKB:Q64727}. Cytoplasm, perinuclear
    region {ECO:00 ...
  uniprot_function: Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates
    cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important
    roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
  uniprot_features: &id219 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id220
  - term: GO:0002102 podosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-482772
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6798749
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-445699
    - TAS Reactome:R-HSA-445700
    - TAS Reactome:R-HSA-445704
    - TAS Reactome:R-HSA-445705
    - TAS Reactome:R-HSA-482772
    - TAS Reactome:R-HSA-9861485
    - TAS Reactome:R-HSA-9934294
    - TAS Reactome:R-HSA-9934410
  - term: GO:0005856 cytoskeleton
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005856 cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - TAS PMID:16130169
  - term: GO:0005886 plasma membrane
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005911 cell-cell junction
    qualifier: located_in
    evidence:
    - IMP PMID:25753039
    - ISS GO_REF:0000024
  - term: GO:0005912 adherens junction
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005912 adherens junction
    qualifier: located_in
    evidence:
    - IDA PMID:20086044
    - IDA PMID:26923917
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0005925 focal adhesion
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005925 focal adhesion
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:15070891
    - IDA PMID:20086044
    - IDA PMID:29162887
    - IEA GO_REF:0000120
    - IMP PMID:26923917
    - ISS GO_REF:0000024
  - term: GO:0015629 actin cytoskeleton
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000002
  - term: GO:0016020 membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0030016 myofibril
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
  - term: GO:0030055 cell-substrate junction
    qualifier: located_in
    evidence:
    - NAS PMID:2116004
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:9700171
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0035580 specific granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798749
  - term: GO:0042383 sarcolemma
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:0043034 costamere
    qualifier: located_in
    evidence:
    - IDA PMID:9415431
    - ISS GO_REF:0000024
  - term: GO:0044291 cell-cell contact zone
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0044291 cell-cell contact zone
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000117
    - IMP PMID:26923917
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
    - ISS GO_REF:0000024
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
- organism: human
  gene: VCL
  row_index: 99
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection in exosomes; not a functional location.
  uniprot_subcellular_location: Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003};
    Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Cell
    membrane, sarcolemma {ECO:0000250|UniProtKB:Q64727}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64727}; Cytoplasmic
    side {ECO:0000250|UniProtKB:Q64727}. Cell projection, podosome {ECO:0000250|UniProtKB:Q64727}. Cytoplasm, perinuclear
    region {ECO:00 ...
  uniprot_function: Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates
    cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important
    roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
  uniprot_features: *id219
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id220
- organism: human
  gene: VCL
  row_index: 103
  term: GO:1903561 extracellular vesicle
  reference: PMID:24769233
  reference_title: 'Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: High-throughput detection; not a functional location.
  uniprot_subcellular_location: Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003};
    Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell
    junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Cell
    membrane, sarcolemma {ECO:0000250|UniProtKB:Q64727}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64727}; Cytoplasmic
    side {ECO:0000250|UniProtKB:Q64727}. Cell projection, podosome {ECO:0000250|UniProtKB:Q64727}. Cytoplasm, perinuclear
    region {ECO:00 ...
  uniprot_function: Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates
    cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important
    roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
  uniprot_features: *id219
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id220
- organism: human
  gene: VCP
  row_index: 202
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: VCP presence in exosomes likely reflects its cytoplasmic abundance rather than a specific exosomal function.
    High-throughput data.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}.
    Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}.
    Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis
    patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787).
    Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:161683 ...
  uniprot_function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.
    Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic
    reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles wh ...
  uniprot_features: &id221 []
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: &id222
  - term: GO:0000153 cytoplasmic ubiquitin ligase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0000502 proteasome complex
    qualifier: part_of
    evidence:
    - IDA PMID:9452483
  - term: GO:0005576 extracellular region
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
    - TAS Reactome:R-HSA-6798751
    - TAS Reactome:R-HSA-6800434
  - term: GO:0005634 nucleus
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - EXP PMID:23042605
    - IDA PMID:10855792
    - IDA PMID:26842564
    - IEA GO_REF:0000044
    - TAS PMID:16130169
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-5654985
    - TAS Reactome:R-HSA-5654989
    - TAS Reactome:R-HSA-5688834
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:27753622
    - NAS PMID:16601695
  - term: GO:0005783 endoplasmic reticulum
    qualifier: located_in
    evidence:
    - IDA PMID:15215856
    - IDA PMID:24089527
    - IEA GO_REF:0000044
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: is_active_in
    evidence:
    - IDA PMID:24129571
  - term: GO:0005789 endoplasmic reticulum membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17872946
    - IEA GO_REF:0000107
    - NAS PMID:16449189
    - NAS PMID:37831771
    - TAS Reactome:R-HSA-8943080
    - TAS Reactome:R-HSA-8943083
  - term: GO:0005811 lipid droplet
    qualifier: located_in
    evidence:
    - IDA PMID:23297223
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
    - IMP PMID:38710747
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - IDA PMID:10855792
    - IDA PMID:15215856
    - IEA GO_REF:0000120
    - TAS PMID:16186510
    - TAS Reactome:R-HSA-5324632
    - TAS Reactome:R-HSA-5362412
    - TAS Reactome:R-HSA-5362441
    - TAS Reactome:R-HSA-5362459
    - TAS Reactome:R-HSA-5387386
    - TAS Reactome:R-HSA-5387389
    - TAS Reactome:R-HSA-5483238
    - TAS Reactome:R-HSA-6781953
    - TAS Reactome:R-HSA-8850594
    - TAS Reactome:R-HSA-8866542
    - TAS Reactome:R-HSA-8866546
    - TAS Reactome:R-HSA-8866551
    - TAS Reactome:R-HSA-8866854
    - TAS Reactome:R-HSA-8866856
    - TAS Reactome:R-HSA-8866857
    - TAS Reactome:R-HSA-8932276
    - TAS Reactome:R-HSA-9755507
    - TAS Reactome:R-HSA-9758088
    - TAS Reactome:R-HSA-9758090
    - TAS Reactome:R-HSA-9931264
    - TAS Reactome:R-HSA-9931298
    - TAS Reactome:R-HSA-9931313
    - TAS Reactome:R-HSA-9948427
  - term: GO:0010494 cytoplasmic stress granule
    qualifier: located_in
    evidence:
    - IDA PMID:29804830
    - IEA GO_REF:0000044
  - term: GO:0032991 protein-containing complex
    qualifier: part_of
    evidence:
    - IDA PMID:21822278
    - IDA PMID:23349634
    - IEA GO_REF:0000107
  - term: GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
    - TAS PMID:16186510
  - term: GO:0034774 secretory granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798748
  - term: GO:0035578 azurophil granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6798751
  - term: GO:0035861 site of double-strand break
    qualifier: located_in
    evidence:
    - IDA PMID:22120668
  - term: GO:0036513 Derlin-1 retrotranslocation complex
    qualifier: part_of
    evidence:
    - IDA PMID:15215856
    - IDA PMID:17872946
    - IEA GO_REF:0000107
  - term: GO:0043231 intracellular membrane-bounded organelle
    qualifier: located_in
    evidence:
    - ISS GO_REF:0000024
  - term: GO:0045202 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0048471 perinuclear region of cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:16275660
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1904813 ficolin-1-rich granule lumen
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-6800434
  - term: GO:1904949 ATPase complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000107
  - term: GO:1990730 VCP-NSFL1C complex
    qualifier: part_of
    evidence:
    - IEA GO_REF:0000120
    - ISS GO_REF:0000024
- organism: human
  gene: VCP
  row_index: 211
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: VCP in exosomes reflects its cytoplasmic abundance. High-throughput data.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}.
    Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}.
    Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis
    patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787).
    Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:161683 ...
  uniprot_function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.
    Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic
    reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles wh ...
  uniprot_features: *id221
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id222
- organism: human
  gene: VCP
  row_index: 214
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: VCP in exosomes reflects its cytoplasmic abundance. High-throughput data.
  uniprot_subcellular_location: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}.
    Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}.
    Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis
    patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787).
    Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:161683 ...
  uniprot_function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.
    Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic
    reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles wh ...
  uniprot_features: *id221
  gene_vesicle_rows: 3
  gene_vesicle_references: 3
  leads: *id222
- organism: human
  gene: VPS28
  row_index: 44
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Plasma-membrane viral budding and extracellular vesicle/exosome contexts use ESCRT machinery but are secondary
    to the core VPS28 ESCRT-I endosomal sorting and PN autophagophore-sealing role.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981};
    Peripheral membrane protein {ECO:0000269|PubMed:11916981}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.
  uniprot_features: &id223 []
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: &id224
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:20654576
    - IDA PMID:21757351
    - IDA PMID:22232651
    - IEA GO_REF:0000120
    - IPI PMID:18005716
    - IPI PMID:21757351
    - IPI PMID:32424346
    - TAS PMID:20588296
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:18077552
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:11134028
    - IDA PMID:17940959
  - term: GO:0005769 early endosome
    qualifier: located_in
    evidence:
    - IDA PMID:11916981
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA PMID:11134028
    - IEA GO_REF:0000107
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17940959
    - IEA GO_REF:0000044
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:11134028
    - NAS PMID:32424346
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: VPS28
  row_index: 50
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Plasma-membrane viral budding and extracellular vesicle/exosome contexts use ESCRT machinery but are secondary
    to the core VPS28 ESCRT-I endosomal sorting and PN autophagophore-sealing role.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981};
    Peripheral membrane protein {ECO:0000269|PubMed:11916981}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.
  uniprot_features: *id223
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id224
- organism: human
  gene: VPS28
  row_index: 51
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Plasma-membrane viral budding and extracellular vesicle/exosome contexts use ESCRT machinery but are secondary
    to the core VPS28 ESCRT-I endosomal sorting and PN autophagophore-sealing role.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981};
    Peripheral membrane protein {ECO:0000269|PubMed:11916981}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.
  uniprot_features: *id223
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id224
- organism: human
  gene: VPS28
  row_index: 52
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Plasma-membrane viral budding and extracellular vesicle/exosome contexts use ESCRT machinery but are secondary
    to the core VPS28 ESCRT-I endosomal sorting and PN autophagophore-sealing role.
  uniprot_subcellular_location: Cell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981};
    Peripheral membrane protein {ECO:0000269|PubMed:11916981}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.
  uniprot_features: *id223
  gene_vesicle_rows: 4
  gene_vesicle_references: 4
  leads: *id224
- organism: human
  gene: VPS37B
  row_index: 39
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect ESCRT machinery
    but are secondary to the core endosomal ESCRT-I sorting role.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000269|PubMed:15218037}; Peripheral membrane protein {ECO:0000269|PubMed:15218037}.
    Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.
  uniprot_features: &id225 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id226
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:22232651
    - IDA PMID:22405001
    - IEA GO_REF:0000117
    - IPI PMID:18005716
    - IPI PMID:21757351
    - IPI PMID:32424346
    - TAS PMID:20588296
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:15218037
  - term: GO:0005768 endosome
    qualifier: located_in
    evidence:
    - IDA PMID:17940959
  - term: GO:0005886 plasma membrane
    qualifier: located_in
    evidence:
    - IDA PMID:17940959
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - IDA PMID:15218037
    - NAS PMID:32424346
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0030496 midbody
    qualifier: located_in
    evidence:
    - IDA PMID:19129479
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: VPS37B
  row_index: 41
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect ESCRT machinery
    but are secondary to the core endosomal ESCRT-I sorting role.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000269|PubMed:15218037}; Peripheral membrane protein {ECO:0000269|PubMed:15218037}.
    Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.
  uniprot_features: *id225
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id226
- organism: human
  gene: VPS37C
  row_index: 29
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is not the central VPS37C ESCRT-I endosomal sorting function.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000305|PubMed:15509564}; Peripheral membrane protein {ECO:0000305|PubMed:15509564}.
    Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15509564}.
  uniprot_features: &id227 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id228
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:22405001
    - IEA GO_REF:0000117
    - IPI PMID:18005716
    - IPI PMID:21757351
    - TAS PMID:20588296
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32424346
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: VPS37C
  row_index: 30
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is not the central VPS37C ESCRT-I endosomal sorting function.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000305|PubMed:15509564}; Peripheral membrane protein {ECO:0000305|PubMed:15509564}.
    Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15509564}.
  uniprot_features: *id227
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id228
- organism: human
  gene: VPS37D
  row_index: 18
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is not the central VPS37D ESCRT-I endosomal sorting function.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
  uniprot_features: &id229 []
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: &id230
  - term: GO:0000813 ESCRT I complex
    qualifier: part_of
    evidence:
    - IBA GO_REF:0000033
    - IDA PMID:18005716
    - IDA PMID:22405001
    - IEA GO_REF:0000117
    - IPI PMID:18005716
    - IPI PMID:21757351
    - TAS PMID:20588296
  - term: GO:0010008 endosome membrane
    qualifier: located_in
    evidence:
    - NAS PMID:32424346
    - TAS Reactome:R-HSA-184269
    - TAS Reactome:R-HSA-3149434
    - TAS Reactome:R-HSA-3159232
    - TAS Reactome:R-HSA-917696
    - TAS Reactome:R-HSA-917730
  - term: GO:0031902 late endosome membrane
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
- organism: human
  gene: VPS37D
  row_index: 19
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Exosome detection is not the central VPS37D ESCRT-I endosomal sorting function.
  uniprot_subcellular_location: Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
  uniprot_function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
  uniprot_features: *id229
  gene_vesicle_rows: 2
  gene_vesicle_references: 2
  leads: *id230
- organism: human
  gene: YWHAZ
  row_index: 174
  term: GO:0031982 vesicle
  reference: PMID:19190083
  reference_title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a
    possible role in innate defense.'
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: HDA vesicle-fraction capture; non-core localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located
    to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
  uniprot_function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
    Binds to a large number of partners, usually by recognition of a ...
  uniprot_features: &id231 []
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: &id232
  - term: GO:0005634 nucleus
    qualifier: located_in
    evidence:
    - IDA PMID:31906564
    - IEA GO_REF:0000107
  - term: GO:0005654 nucleoplasm
    qualifier: located_in
    evidence:
    - TAS Reactome:R-HSA-3769391
    - TAS Reactome:R-HSA-3769392
    - TAS Reactome:R-HSA-3769393
    - TAS Reactome:R-HSA-450620
  - term: GO:0005737 cytoplasm
    qualifier: is_active_in
    evidence:
    - IBA GO_REF:0000033
  - term: GO:0005737 cytoplasm
    qualifier: located_in
    evidence:
    - IDA PMID:31906564
    - IEA GO_REF:0000044
    - TAS PMID:16130169
  - term: GO:0005829 cytosol
    qualifier: is_active_in
    evidence:
    - IDA PMID:35662396
  - term: GO:0005829 cytosol
    qualifier: located_in
    evidence:
    - IDA GO_REF:0000052
    - TAS Reactome:R-HSA-139899
    - TAS Reactome:R-HSA-139906
    - TAS Reactome:R-HSA-3769392
    - TAS Reactome:R-HSA-430073
    - TAS Reactome:R-HSA-430076
    - TAS Reactome:R-HSA-443402
    - TAS Reactome:R-HSA-443831
    - TAS Reactome:R-HSA-5632732
    - TAS Reactome:R-HSA-5632738
    - TAS Reactome:R-HSA-75016
    - TAS Reactome:R-HSA-912757
    - TAS Reactome:R-HSA-913993
    - TAS Reactome:R-HSA-914182
    - TAS Reactome:R-HSA-9614423
    - TAS Reactome:R-HSA-9614562
    - TAS Reactome:R-HSA-9614564
    - TAS Reactome:R-HSA-9727919
    - TAS Reactome:R-HSA-9729500
  - term: GO:0042470 melanosome
    qualifier: located_in
    evidence:
    - IEA GO_REF:0000044
  - term: GO:0098686 hippocampal mossy fiber to CA3 synapse
    qualifier: is_active_in
    evidence:
    - IEA GO_REF:0000107
  - term: GO:0098978 glutamatergic synapse
    qualifier: is_active_in
    evidence:
    - IDA PMID:16959763
    - IMP PMID:16959763
- organism: human
  gene: YWHAZ
  row_index: 181
  term: GO:0070062 extracellular exosome
  reference: PMID:23533145
  reference_title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant-protein exosome capture; non-core localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located
    to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
  uniprot_function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
    Binds to a large number of partners, usually by recognition of a ...
  uniprot_features: *id231
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id232
- organism: human
  gene: YWHAZ
  row_index: 185
  term: GO:0072562 blood microparticle
  reference: PMID:22516433
  reference_title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Extracellular-vesicle proteomic capture; non-core.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located
    to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
  uniprot_function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
    Binds to a large number of partners, usually by recognition of a ...
  uniprot_features: *id231
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id232
- organism: human
  gene: YWHAZ
  row_index: 187
  term: GO:0070062 extracellular exosome
  reference: PMID:19199708
  reference_title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology
    (MudPIT).
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant-protein exosome capture; non-core localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located
    to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
  uniprot_function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
    Binds to a large number of partners, usually by recognition of a ...
  uniprot_features: *id231
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id232
- organism: human
  gene: YWHAZ
  row_index: 188
  term: GO:0070062 extracellular exosome
  reference: PMID:19056867
  reference_title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant-protein exosome capture; non-core localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located
    to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
  uniprot_function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
    Binds to a large number of partners, usually by recognition of a ...
  uniprot_features: *id231
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id232
- organism: human
  gene: YWHAZ
  row_index: 189
  term: GO:0070062 extracellular exosome
  reference: PMID:20458337
  reference_title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  evidence_type: HDA
  current_action: KEEP_AS_NON_CORE
  current_reason: Abundant-protein exosome capture; non-core localization.
  uniprot_subcellular_location: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Located
    to stage I to stage IV melanosomes. {ECO:0000269|PubMed:17081065}.
  uniprot_function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
    Binds to a large number of partners, usually by recognition of a ...
  uniprot_features: *id231
  gene_vesicle_rows: 6
  gene_vesicle_references: 6
  leads: *id232