Parasites

GO review of nematode genes that work at the host interface

AI Gene Review · projects/PARASITES · 2026

Bottom line

  • Parasites invade hosts, evade immunity and steal nutrients; these functions are thinly covered by GO, and parasite species have few reviewed UniProt entries.
  • We anchored on S. carpocapsae nas-8 (the genus's only Swiss-Prot entry) and five Brugia malayi secreted or surface proteins.
  • All 6 reviewed: 35 GOA rows, 21 ACCEPT. Key fix: a CPI-2 aspartic-type inhibitor row → cysteine-type, since legumain is a cysteine protease.

Why these species

What the six proteins do at the host interface

Review outcomes

Gene Species Rows ACCEPT Non-core Over-ann. MODIFY REMOVE
nas-8 S. carpocapsae 6 4 1 1 0 0
cpi-2 B. malayi 6 3 1 0 1 1
far-1 B. malayi 5 4 0 1 0 0
dpy-31 B. malayi 6 4 1 1 0 0
gp29 B. malayi 5 3 1 1 0 0
mf1 B. malayi 7 3 2 0 2 0

From genes/{STECR,BRUMA}/<gene>/<gene>-ai-review.yaml. Over-annotations are generic parents (metallopeptidase, peroxidase, lipid binding); mf1 MODIFYs move to chitinase and chitin catabolism.

A mis-typed protease inhibitor

cpi-2: the IDA row from PMID:15664654 said aspartic-type; the target (AEP/legumain) is a cysteine peptidase, so it becomes GO:0004869. Above it, the TreeGrafter cytoplasm row is removed for a secreted protein.

Status and next steps

  • ✅ 6/6 seed genes reviewed and rendered (the project page's "PENDING" labels are out of date).
  • ⬜ No deep research or notes files yet; reviews rest on UniProt and cached papers.
  • ⬜ S. hermaphroditum (9BILA): no seed chosen, no reviewed entries; will need literature + bioinformatics.
  • ⬜ Fold in the host-modulator candidates from PARASITE_IMMUNE_MODULATORS.

Read more: projects/PARASITES.md · genes/BRUMA/ · genes/STECR/nas-8/