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"O88950", "Q15647", "Q3V1W6", "Q8R5B0", "Q9CWU1", "Q9R249", "Q9UNQ5" ], "uniProtkbId": "CSN2_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "value": "Cops2" }, "synonyms": [ { "value": "Csn2" }, { "value": "Trip15" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "COP9 signalosome complex subunit 2" }, "shortNames": [ { "value": "SGN2" }, { "value": "Signalosome subunit 2" } ] }, "alternativeNames": [ { "fullName": { "value": "Alien homolog" } }, { "fullName": { "value": "JAB1-containing signalosome subunit 2" } }, { "fullName": { "value": "Thyroid receptor-interacting protein 15" }, "shortNames": [ { "value": "TR-interacting protein 15" }, { "value": "TRIP-15" } ] } ] }, "entryAudit": { "firstPublicDate": "2004-05-10", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "2004-05-10", "entryVersion": 169, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "11967155" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "12522100" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "12972599" } ], "value": "Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. 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"targetSets": null, "symbol": "Cops2", "date": "20260723", "synonyms": null, "name": null } ] }, "Q8VBV7": { "organism": "mouse", "gene": "Cops8", "taxon_id": 10090, "total_goa_rows_fetched": 28, "aliases": [ "Cops8", "Csn8" ], "accessions": [ "Q3TRS9", "Q80XF4", "Q8R4D2", "Q8VBV7" ], "uniprot": { "primaryAccession": "Q8VBV7", "secondaryAccessions": [ "Q3TRS9", "Q80XF4", "Q8R4D2" ], "uniProtkbId": "CSN8_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "value": "Cops8" }, "synonyms": [ { "value": "Csn8" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "COP9 signalosome complex subunit 8" }, "shortNames": [ { "value": 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The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:Q8VBV7!387741043", "geneProductId": "UniProtKB:Q8VBV7", "qualifier": "enables", "goId": "GO:0005515", "goName": null, "goEvidence": "IPI", "goAspect": "molecular_function", "evidenceCode": "ECO:0000353", "reference": "PMID:9707402", "withFrom": [ { "connectedXrefs": [ { "db": "PR", "id": "O35864" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": [ { "connectedXrefs": [ { "db": "PR", "id": "O35864", "relation": "has_input" } ] } ], "targetSets": null, "symbol": "Cops8", "date": "20200325", "synonyms": null, "name": null }, { "id": "UniProtKB:Q8VBV7!387741044", "geneProductId": "UniProtKB:Q8VBV7", "qualifier": "enables", "goId": "GO:0005515", "goName": null, "goEvidence": "IPI", "goAspect": "molecular_function", "evidenceCode": "ECO:0000353", "reference": 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"qualifier": "enables", "goId": "GO:0005515", "goName": null, "goEvidence": "IPI", "goAspect": "molecular_function", "evidenceCode": "ECO:0000353", "reference": "PMID:9707402", "withFrom": [ { "connectedXrefs": [ { "db": "PR", "id": "O88545" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": [ { "connectedXrefs": [ { "db": "PR", "id": "O88545", "relation": "has_input" } ] } ], "targetSets": null, "symbol": "Cops8", "date": "20200325", "synonyms": null, "name": null }, { "id": "UniProtKB:Q8VBV7!387741047", "geneProductId": "UniProtKB:Q8VBV7", "qualifier": "enables", "goId": "GO:0005515", "goName": null, "goEvidence": "IPI", "goAspect": "molecular_function", "evidenceCode": "ECO:0000353", "reference": "PMID:9707402", "withFrom": [ { "connectedXrefs": [ { "db": "PR", "id": "P61202" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": [ { "connectedXrefs": [ { "db": "PR", "id": "P61202", "relation": "has_input" } ] } ], "targetSets": null, "symbol": "Cops8", "date": "20200325", "synonyms": null, "name": null }, { "id": "UniProtKB:Q8VBV7!387741048", "geneProductId": "UniProtKB:Q8VBV7", "qualifier": "enables", "goId": "GO:0005515", "goName": null, "goEvidence": "IPI", "goAspect": "molecular_function", "evidenceCode": "ECO:0000353", "reference": "PMID:9707402", "withFrom": [ { "connectedXrefs": [ { "db": "PR", "id": "Q99LD4" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": [ { "connectedXrefs": [ { "db": "PR", "id": "Q99LD4", "relation": "has_input" } ] } ], "targetSets": null, "symbol": "Cops8", "date": "20200325", "synonyms": null, "name": null }, { "id": "UniProtKB:Q8VBV7!387741051", "geneProductId": "UniProtKB:Q8VBV7", "qualifier": "involved_in", "goId": "GO:0006468", "goName": null, "goEvidence": "ISO", "goAspect": "biological_process", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000119", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q99627" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Cops8", "date": "20260723", "synonyms": null, "name": null } ] }, "Q99MI1": { "organism": "mouse", "gene": "Erc1", "taxon_id": 10090, "total_goa_rows_fetched": 62, "aliases": [ "Cast2", "Erc1", "Kiaa1081", "Rab6ip2" ], "accessions": [ "Q80TK7", "Q8BPL1", "Q8C7Y1", "Q99MI1", "Q99MI2" ], "uniprot": { "primaryAccession": "Q99MI1", "secondaryAccessions": [ "Q80TK7", "Q8BPL1", "Q8C7Y1", "Q99MI2" ], "uniProtkbId": "RB6I2_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "evidences": [ { "evidenceCode": "ECO:0000312", "source": "MGI", "id": "MGI:2151013" } ], "value": "Erc1" }, "synonyms": [ { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "14723704" } ], "value": "Cast2" }, { "value": "Kiaa1081" }, { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "11929610" } ], "value": "Rab6ip2" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "evidences": [ { "evidenceCode": "ECO:0000305" } ], "value": "ELKS/Rab6-interacting/CAST family member 1" }, "shortNames": [ { "value": "ERC-1" } ] }, "alternativeNames": [ { "fullName": { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "14723704" } ], "value": "CAZ-associated structural protein 2" }, "shortNames": [ { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "14723704" } ], "value": "CAST2" } ] }, { "fullName": { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "11929610" } ], "value": "Rab6-interacting protein 2" } } ] }, "entryAudit": { "firstPublicDate": "2004-08-31", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "2001-06-01", "entryVersion": 177, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250" } ], "value": "Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. 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"taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Grm5", "date": "20260528", "synonyms": null, "name": null } ] }, "Q9QUJ0": { "organism": "mouse", "gene": "Hcst", "taxon_id": 10090, "total_goa_rows_fetched": 28, "aliases": [ "Dap10", "Hcst", "Kap10" ], "accessions": [ "Q9QUJ0", "Q9R1E7" ], "uniprot": { "primaryAccession": "Q9QUJ0", "secondaryAccessions": [ "Q9R1E7" ], "uniProtkbId": "HCST_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "value": "Hcst" }, "synonyms": [ { "value": "Dap10" }, { "value": "Kap10" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "Hematopoietic cell signal transducer" } }, "alternativeNames": [ { "fullName": { "value": "DNAX-activation protein 10" } }, { "fullName": { "value": "Membrane protein DAP10" } }, { "fullName": { "value": "Transmembrane adapter protein KAP10" } } ], "flag": "Precursor" }, "entryAudit": { "firstPublicDate": "2008-04-29", "lastAnnotationUpdateDate": "2026-06-10", "lastSequenceUpdateDate": "2000-05-01", "entryVersion": 147, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "10528161" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "12426565" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "15365099" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "16086018" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "16887996" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "17100879" } ], "value": "Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:Q9QUJ0!29337605", "geneProductId": "UniProtKB:Q9QUJ0", "qualifier": "enables", "goId": "GO:0005102", "goName": null, "goEvidence": "ISO", "goAspect": "molecular_function", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000119", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9UBK5" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Hcst", "date": "20260723", "synonyms": null, "name": null }, { "id": "UniProtKB:Q9QUJ0!29337606", "geneProductId": "UniProtKB:Q9QUJ0", "qualifier": "enables", "goId": "GO:0005102", "goName": null, "goEvidence": "IEA", "goAspect": "molecular_function", "evidenceCode": 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"UniProtKB:Q9QUJ0!29337617", "geneProductId": "UniProtKB:Q9QUJ0", "qualifier": "involved_in", "goId": "GO:0006468", "goName": null, "goEvidence": "ISO", "goAspect": "biological_process", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000119", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9UBK5" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Hcst", "date": "20260723", "synonyms": null, "name": null } ] }, "Q9ES17": { "organism": "mouse", "gene": "Il21", "taxon_id": 10090, "total_goa_rows_fetched": 37, "aliases": [ "Il21" ], "accessions": [ "Q9ES17" ], "uniprot": { "primaryAccession": "Q9ES17", "uniProtkbId": "IL21_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "value": "Il21" } } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "Interleukin-21" }, "shortNames": [ { "value": "IL-21" } ] }, "flag": "Precursor" }, "entryAudit": { "firstPublicDate": "2004-11-23", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "2001-03-01", "entryVersion": 154, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q9HBE4" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "11970879" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "12893770" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "15100251" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "23045607" } ], "value": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (PubMed:15100251). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed:11970879). May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed:12893770)" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:Q9ES17!447558335", "geneProductId": "UniProtKB:Q9ES17", "qualifier": "enables", "goId": "GO:0005126", "goName": null, "goEvidence": "IEA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000256", "reference": "GO_REF:0000002", "withFrom": [ { "connectedXrefs": [ { "db": "InterPro", "id": "IPR003443" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "InterPro", "extensions": null, "targetSets": null, "symbol": "Il21", "date": "20260727", "synonyms": null, "name": null }, { "id": "UniProtKB:Q9ES17!447558336", "geneProductId": "UniProtKB:Q9ES17", "qualifier": "enables", "goId": "GO:0005126", "goName": null, "goEvidence": "IDA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000314", "reference": "PMID:11081504", "withFrom": null, "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": null, "targetSets": null, "symbol": "Il21", "date": "20010208", "synonyms": null, "name": null }, { "id": "UniProtKB:Q9ES17!447558337", "geneProductId": "UniProtKB:Q9ES17", "qualifier": "enables", "goId": "GO:0005134", "goName": null, "goEvidence": "IEA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000265", "reference": "GO_REF:0000107", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9HBE4" } ] }, { "connectedXrefs": [ { "db": "ensembl", "id": "ENSP00000497915" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "Ensembl", "extensions": null, "targetSets": null, "symbol": "Il21", "date": "20260724", "synonyms": null, "name": null }, { "id": "UniProtKB:Q9ES17!447558338", "geneProductId": "UniProtKB:Q9ES17", "qualifier": "enables", "goId": "GO:0005134", "goName": null, "goEvidence": "ISO", "goAspect": "molecular_function", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000119", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9HBE4" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Il21", "date": "20260723", "synonyms": null, "name": null }, { "id": "UniProtKB:Q9ES17!447558346", "geneProductId": "UniProtKB:Q9ES17", "qualifier": "involved_in", "goId": "GO:0007260", "goName": null, "goEvidence": "ISO", "goAspect": "biological_process", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000119", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9HBE4" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Il21", "date": "20260723", "synonyms": null, "name": null } ] }, "Q925S4": { "organism": "mouse", "gene": "Il24", "taxon_id": 10090, "total_goa_rows_fetched": 20, "aliases": [ "Il24", "Mda7" ], "accessions": [ "A3QQZ3", "Q925J3", "Q925S4" ], "uniprot": { "primaryAccession": "Q925S4", "secondaryAccessions": [ "A3QQZ3", "Q925J3" ], "uniProtkbId": "IL24_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "value": "Il24" }, "synonyms": [ { "value": "Mda7" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "Interleukin-24" }, "shortNames": [ { "value": "IL-24" } ] }, "alternativeNames": [ { "fullName": { "value": "IL-4-induced secreted protein" } }, { "fullName": { "value": "Melanoma differentiation-associated gene 7 protein" }, "shortNames": [ { "value": "MDA-7" } ] }, { "fullName": { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "11342597" } ], "value": "Th2-specific cytokine FISP" } } ], "flag": "Precursor" }, "entryAudit": { "firstPublicDate": "2005-10-11", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "2026-01-28", "entryVersion": 146, "sequenceVersion": 2 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q13007" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "31907348" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35148201" } ], "value": "Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:31907348, PubMed:35148201). Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (By similarity). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (PubMed:31907348). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (PubMed:35148201)" } ], "commentType": "FUNCTION" }, { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "18708357" } ], "value": "May negatively regulate isoform 1 activity by causing its retention in the endoplasmic reticulum and increasing isoform 1 degradation by the ubiquitin proteasome pathway" } ], "commentType": "FUNCTION", "molecule": "Isoform 2" } ], "goa_rows": [ { "id": "UniProtKB:Q925S4!118905561", "geneProductId": "UniProtKB:Q925S4", "qualifier": "enables", "goId": "GO:0005125", "goName": null, "goEvidence": "IBA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000318", "reference": "GO_REF:0000033", "withFrom": [ { "connectedXrefs": [ { "db": "MGI", "id": "MGI:1890473" } ] }, { "connectedXrefs": [ { "db": "MGI", "id": "MGI:96537" } ] }, { "connectedXrefs": [ { "db": "PANTHER", "id": "PTN009232391" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "P22301" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9NPH9" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Il24", "date": "20241010", "synonyms": null, "name": null }, { "id": "UniProtKB:Q925S4!118905562", "geneProductId": "UniProtKB:Q925S4", "qualifier": "enables", "goId": "GO:0005125", "goName": null, "goEvidence": "ISA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000247", "reference": "PMID:11342597", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "P18893" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": null, "targetSets": null, "symbol": "Il24", "date": "20110404", "synonyms": null, "name": null }, { "id": "UniProtKB:Q925S4!118905563", "geneProductId": "UniProtKB:Q925S4", "qualifier": "enables", "goId": "GO:0005125", "goName": null, "goEvidence": "ISA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000247", "reference": "PMID:11342597", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9JKV9" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": null, "targetSets": null, "symbol": "Il24", "date": "20110404", "synonyms": null, "name": null }, { "id": "UniProtKB:Q925S4!118905570", "geneProductId": "UniProtKB:Q925S4", "qualifier": "involved_in", "goId": "GO:0042501", "goName": null, "goEvidence": "ISO", "goAspect": "biological_process", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000096", "withFrom": [ { "connectedXrefs": [ { "db": "RGD", "id": "621484" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Il24", "date": "20260702", "synonyms": null, "name": null } ] }, "Q8BWD2": { "organism": "mouse", "gene": "Ip6k3", "taxon_id": 10090, "total_goa_rows_fetched": 20, "aliases": [ "Ihpk3", "Ip6k3" ], "accessions": [ "Q8BWD2" ], "uniprot": { "primaryAccession": "Q8BWD2", "uniProtkbId": "IP6K3_MOUSE", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "value": "Ip6k3" }, "synonyms": [ { "value": "Ihpk3" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "Inositol hexakisphosphate kinase 3" }, "shortNames": [ { "value": "InsP6 kinase 3" } ], "ecNumbers": [ { "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q96PC2" } ], "value": "2.7.4.21" } ] }, "alternativeNames": [ { "fullName": { "value": "Inositol hexaphosphate kinase 3" } } ] }, "entryAudit": { "firstPublicDate": "2004-07-19", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "2003-03-01", "entryVersion": 141, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q96PC2" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "26245967" } ], "value": "Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). In turn, the generated InsP7 binds to the SPX domain of the XPR1 phosphate exporter to stimulate cellular phosphate export (PubMed:26245967). Regulates also synaptic disposition noncatalytically via influences upon specific cytoskeletal proteins including spectrin and alpha- and beta adducin (PubMed:26245967)" } ], "commentType": "FUNCTION" }, { "commentType": "CATALYTIC ACTIVITY", "reaction": { "name": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "reactionCrossReferences": [ { "database": "Rhea", "id": "RHEA:12793" }, { "database": "ChEBI", "id": "CHEBI:30616" }, { "database": "ChEBI", "id": "CHEBI:58130" }, { "database": "ChEBI", "id": "CHEBI:58628" }, { "database": "ChEBI", "id": "CHEBI:456216" } ], "ecNumber": "2.7.4.21", "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q96PC2" } ] } } ], "goa_rows": [ { "id": "UniProtKB:Q8BWD2!148721409", "geneProductId": "UniProtKB:Q8BWD2", "qualifier": "enables", "goId": "GO:0000828", "goName": null, "goEvidence": "IBA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000318", 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differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:Q9QXD8!387822269", "geneProductId": "UniProtKB:Q9QXD8", "qualifier": "enables", "goId": "GO:0003714", "goName": null, "goEvidence": "IBA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000318", "reference": "GO_REF:0000033", "withFrom": [ { "connectedXrefs": [ { "db": "MGI", "id": "MGI:1341886" } ] }, { "connectedXrefs": [ { "db": "MGI", "id": "MGI:1352502" } ] }, { "connectedXrefs": [ { "db": "MGI", "id": "MGI:2141920" } ] }, { "connectedXrefs": [ { "db": "PANTHER", "id": "PTN001198456" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "A9LS46" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q06BR1" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q96IF1" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Limd1", "date": "20250903", "synonyms": 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Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:17205979). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:17205979). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:17205979, PubMed:19078967, PubMed:9230306). Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity). 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RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (By similarity). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). Necessary for the development and survival of sensory neurons expressing parvalbumin (PubMed:39919739)" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:Q64131!88843782", "geneProductId": "UniProtKB:Q64131", "qualifier": "enables", "goId": "GO:0000977", "goName": null, "goEvidence": "IDA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000314", "reference": "PMID:17352693", "withFrom": null, "taxonId": 10090, "taxonName": null, "assignedBy": "BHF-UCL", "extensions": [ { "connectedXrefs": [ { "db": "UBERON", "id": "0001754", "relation": "occurs_in" } ] } ], "targetSets": null, "symbol": "Runx3", "date": "20120917", "synonyms": null, "name": null }, { "id": "UniProtKB:Q64131!88843783", "geneProductId": "UniProtKB:Q64131", "qualifier": "enables", "goId": "GO:0000978", "goName": null, "goEvidence": "IBA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000318", "reference": "GO_REF:0000033", "withFrom": [ { "connectedXrefs": [ { "db": "MGI", "id": 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"Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus" ] }, "genes": [ { "geneName": { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "16286508" }, { "evidenceCode": "ECO:0000312", "source": "MGI", "id": "MGI:107931" } ], "value": "Sqstm1" }, "synonyms": [ { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "10458914" } ], "value": "A170" }, { "evidences": [ { "evidenceCode": "ECO:0000303", "source": "PubMed", "id": "10458914" } ], "value": "STAP" } ] } ], "proteinDescription": { "recommendedName": { "fullName": { "evidences": [ { "evidenceCode": "ECO:0000305" } ], "value": "Sequestosome-1" } }, "alternativeNames": [ { "fullName": { "value": "STONE14" } }, { "fullName": { "value": "Ubiquitin-binding protein p62" } } ] }, "entryAudit": { "firstPublicDate": "2005-10-11", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "1996-11-01", "entryVersion": 211, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q13501" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "14960283" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "18382763" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "20173742" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "20421418" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "24011591" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "25723488" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "33397898" }, { "evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37306101" } ], "value": "Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:25723488, PubMed:33397898, PubMed:37306101). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:25723488, PubMed:33397898). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:33397898). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:33397898). SQSTM1 is itself degraded along with its ubiquitinated cargos (By similarity). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (By similarity). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20173742, PubMed:20421418, PubMed:24011591, PubMed:33397898, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity). May regulate the activation of NFKB1 by TNF, nerve growth factor (NGF) and interleukin-1 (By similarity). May play a role in titin/TTN downstream signaling in muscle cells (By similarity). Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763)" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:Q64337!447351659", "geneProductId": "UniProtKB:Q64337", "qualifier": "enables", "goId": "GO:0003712", "goName": null, "goEvidence": "TAS", "goAspect": "molecular_function", "evidenceCode": "ECO:0000304", "reference": "PMID:10458914", "withFrom": null, "taxonId": 10090, "taxonName": null, "assignedBy": "MGI", "extensions": null, "targetSets": null, "symbol": "Sqstm1", "date": "20000813", "synonyms": null, "name": null }, { "id": "UniProtKB:Q64337!447351660", "geneProductId": "UniProtKB:Q64337", "qualifier": "enables", "goId": "GO:0005080", "goName": null, "goEvidence": "ISS", "goAspect": "molecular_function", "evidenceCode": "ECO:0000250", "reference": "GO_REF:0000024", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q13501" } ] } ], "taxonId": 10090, "taxonName": null, "assignedBy": "UniProt", "extensions": 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"UniProtKB:P31424!58714269", "geneProductId": "UniProtKB:P31424", "qualifier": "involved_in", "goId": "GO:0006468", "goName": null, "goEvidence": "IDA", "goAspect": "biological_process", "evidenceCode": "ECO:0000314", "reference": "PMID:15758184", "withFrom": null, "taxonId": 10116, "taxonName": null, "assignedBy": "UniProt", "extensions": null, "targetSets": null, "symbol": "Grm5", "date": "20060308", "synonyms": null, "name": null } ] }, "Q9JIL3": { "organism": "rat", "gene": "Ilf3", "taxon_id": 10116, "total_goa_rows_fetched": 38, "aliases": [ "Ilf3" ], "accessions": [ "Q9JIL3" ], "uniprot": { "primaryAccession": "Q9JIL3", "uniProtkbId": "ILF3_RAT", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Rattus norvegicus", "commonName": "Rat", "taxonId": 10116, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", 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Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. 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"Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Rattus" ] }, "genes": [ { "geneName": { "value": "Limd1" } } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "LIM domain-containing protein 1" } } }, "entryAudit": { "firstPublicDate": "2012-04-18", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "2008-10-14", "entryVersion": 98, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250" } ], "value": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation (By similarity)" } ], "commentType": "FUNCTION" } ], "goa_rows": [ { "id": "UniProtKB:B5DEH0!86874200", "geneProductId": "UniProtKB:B5DEH0", "qualifier": "enables", "goId": "GO:0003714", "goName": null, "goEvidence": "ISS", "goAspect": "molecular_function", "evidenceCode": "ECO:0000250", "reference": "GO_REF:0000024", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9QXD8" } ] } ], "taxonId": 10116, "taxonName": null, "assignedBy": "UniProt", "extensions": null, "targetSets": null, "symbol": "Limd1", "date": "20120312", "synonyms": null, "name": null }, { "id": "UniProtKB:B5DEH0!86874201", "geneProductId": "UniProtKB:B5DEH0", "qualifier": "enables", "goId": "GO:0003714", "goName": null, "goEvidence": "IBA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000318", "reference": "GO_REF:0000033", "withFrom": [ { "connectedXrefs": [ { "db": "MGI", "id": "MGI:1341886" } ] }, { "connectedXrefs": [ { "db": "MGI", "id": "MGI:1352502" } ] }, { "connectedXrefs": [ { "db": "MGI", "id": "MGI:2141920" } ] }, { "connectedXrefs": [ { "db": "PANTHER", "id": "PTN001198456" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "A9LS46" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q06BR1" } ] }, { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q96IF1" } ] } ], "taxonId": 10116, "taxonName": null, "assignedBy": "GO_Central", "extensions": null, "targetSets": null, "symbol": "Limd1", "date": "20250903", "synonyms": null, "name": null }, { "id": "UniProtKB:B5DEH0!86874202", "geneProductId": "UniProtKB:B5DEH0", "qualifier": "enables", "goId": "GO:0003714", "goName": null, "goEvidence": "IEA", "goAspect": "molecular_function", "evidenceCode": "ECO:0000265", "reference": "GO_REF:0000107", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9QXD8" } ] }, { "connectedXrefs": [ { "db": "ensembl", "id": "ENSMUSP00000026269" } ] } ], "taxonId": 10116, "taxonName": null, "assignedBy": "Ensembl", "extensions": null, "targetSets": null, "symbol": "Limd1", "date": "20260724", "synonyms": null, "name": null }, { "id": "UniProtKB:B5DEH0!86874203", "geneProductId": "UniProtKB:B5DEH0", "qualifier": "enables", "goId": "GO:0003714", "goName": null, "goEvidence": "ISO", "goAspect": "molecular_function", "evidenceCode": "ECO:0000266", "reference": "GO_REF:0000121", "withFrom": [ { "connectedXrefs": [ { "db": "MGI", "id": "MGI:1352502" } ] } ], "taxonId": 10116, "taxonName": null, "assignedBy": "RGD", "extensions": null, "targetSets": null, "symbol": "Limd1", "date": "20120312", "synonyms": null, "name": null }, { "id": "UniProtKB:B5DEH0!86874210", "geneProductId": "UniProtKB:B5DEH0", "qualifier": "involved_in", "goId": "GO:0016310", "goName": null, "goEvidence": "ISS", "goAspect": "biological_process", "evidenceCode": "ECO:0000250", "reference": "GO_REF:0000024", "withFrom": [ { "connectedXrefs": [ { "db": "UniProtKB", "id": "Q9UGP4" } ] } ], "taxonId": 10116, "taxonName": null, "assignedBy": "UniProt", "extensions": null, "targetSets": null, "symbol": "Limd1", "date": "20120307", "synonyms": null, "name": null } ] }, "Q05028": { "organism": "rat", "gene": "Pdgfb", "taxon_id": 10116, "total_goa_rows_fetched": 171, "aliases": [ "Pdgfb" ], "accessions": [ "Q05028" ], "uniprot": { "primaryAccession": "Q05028", "uniProtkbId": "PDGFB_RAT", "entryType": "UniProtKB reviewed (Swiss-Prot)", "organism": { "scientificName": "Rattus norvegicus", "commonName": "Rat", "taxonId": 10116, "lineage": [ "Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Rattus" ] }, "genes": [ { "geneName": { "value": "Pdgfb" } } ], "proteinDescription": { "recommendedName": { "fullName": { "value": "Platelet-derived growth factor subunit B" }, "shortNames": [ { "value": "PDGF subunit B" } ] }, "alternativeNames": [ { "fullName": { "value": "PDGF-2" } }, { "fullName": { "value": "Platelet-derived growth factor B chain" } }, { "fullName": { "value": "Platelet-derived growth factor beta polypeptide" } } ], "flag": "Fragment,Precursor" }, "entryAudit": { "firstPublicDate": "1994-02-01", "lastAnnotationUpdateDate": "2026-09-02", "lastSequenceUpdateDate": "1994-02-01", "entryVersion": 186, "sequenceVersion": 1 } }, "function_and_catalysis": [ { "texts": [ { "evidences": [ { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P01127" }, { "evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P31240" } ], "value": "Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. 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Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (By similarity). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). 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