value: TNF receptor-associated factor 2

value: E3 ubiquitin-protein ligase TRAF2

value: RING-type E3 ubiquitin transferase TRAF2

value: Tumor necrosis factor type 2 receptor-associated protein 3

source: HGNC

value: E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:10346818, PubMed:11784851, PubMed:12917689, PubMed:15383523, PubMed:18981220, PubMed:19150425, PubMed:19810754, PubMed:19918265, PubMed:19937093, PubMed:20047764, PubMed:20064526, PubMed:20385093, PubMed:20577214, PubMed:22212761). Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1 (PubMed:23453969, PubMed:28489822). Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (PubMed:15383523, PubMed:18981220). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain (PubMed:11907583, PubMed:19506082). Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (PubMed:15121867). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (PubMed:23453969). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex (PubMed:28489822). Required for normal antibody isotype switching from IgM to IgG (By similarity)

name: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

value: Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1-phosphate

value: Protein modification; protein ubiquitination

value: Homotrimer (PubMed:8069916). Heterotrimer with TRAF1 (PubMed:8069916). Heterotrimer with TRAF3 (via TRAF domain) (PubMed:15383523, PubMed:20447407). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro) (PubMed:19810754). Interacts with TNFRSF1B/TNFR2 (PubMed:10206649, PubMed:7639698, PubMed:8069916). Interacts with TNFRSF5/CD40 (PubMed:9718306). Interacts with TNFRSF4, TNFRSF7/CD27, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT and EDAR (PubMed:10037686, PubMed:10411888, PubMed:10514511, PubMed:10809768, PubMed:10880535, PubMed:11035039, PubMed:38354704, PubMed:8627180, PubMed:9153189, PubMed:9418902, PubMed:9488716, PubMed:9607925, PubMed:9692890, PubMed:9774460). Stimulation of TNF receptor TNFRSF1A leads to the formation of two distinct signaling complexes. Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:18981220, PubMed:21307340). Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis (PubMed:21307340). Interacts with TRADD (PubMed:10892748). Identified in a complex with TNFRSF1A, RIPK1 and IKBKB/IKK-beta (PubMed:18981220). Interacts with RIPK2 (PubMed:9705938). Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer (PubMed:11907583, PubMed:19506082, PubMed:20385093, PubMed:20447407). Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3 (By similarity). Interacts with BIRC2; the interaction promotes BIRC2 stability (PubMed:19506082). Interaction with BIRC2 and/or BIRC3 is essential for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B (By similarity). Within complex I, phosphorylated TRAF2 interacts (via 'Lys-63'-linked polyubiquitin chains) with CHUCK/IKK-alpha, IKBKB/IKK-beta, IKBKG/IKK-gamma TAB2, TAB3 and TAK1 in response to TNF stimulation (PubMed:19150425). Within complex I, interacts with UXT isoform 1 (via TPQE motif); the interaction prevents the recruitment of FADD and CASP8/caspase 8 to complex I (PubMed:21307340). Forms a complex composed of TNFRSF8/CD30 or TNFRSF1B/TNFR2, and TRAF1, TRAF2 and E3 ligase TRAIP (PubMed:9104814). Within the complex, interacts with TRAIP; the interaction inhibits TRAF2-mediated NF-kappa B activation (PubMed:9104814). Component of a complex composed of TANK and TBK1 (PubMed:10581243). Interacts with TRPC4AP (By similarity). Interacts with MAP3K1/MEKK1, MAP3K5/ASK1 and MAP3K11/MLK3 in response to TNF stimulation; the interaction leads to JNK activation and interaction with MAP3K5 is inhibited by PRMT1 (PubMed:10346818, PubMed:19918265, PubMed:22095282, PubMed:9774977). Component of a complex composed of MAP3K14/NIK BIRC3 and TRAF3; the interaction leads to BIRC2/3-mediated ubiquitination of TRAF3 upon CD40 engagement in a TRAF2-dependent manner (By similarity). Interacts with MAP3K14/NIK in response to TNF stimulation; the interaction leads to NF-kappa B activation (PubMed:9020361). Interacts with PEG3; the interaction may promote TRAF2-mediated NF-kappa B activation (By similarity). Interacts with HIVEP3; the interaction may inhibit TNF-TRAF2-mediated NF-kappa B and JNK activation (By similarity). Interacts with TANK/ITRAF; the interaction prevents interaction between TNFRSF1B/TNFR2 and TRAF2 (PubMed:8710854). Interacts with deubiquitinating enzyme CYLD; the interaction results in the deubiquitination and inactivation of TRAF2 (PubMed:12917691). Interacts with SIAH2; the interaction leads to TRAF2 ubiquitination and degradation (PubMed:12411493). Interacts with E2 conjugating enzyme UBE2N/Ubc13, E3 ligase ITCH and RNF11 in response to TNF stimulation (By similarity). Interacts with ubiquitin-editing enzyme TNFAIP3/A20 in response to TNF stimulation; the interaction promotes TRAF2 dissociation from UBE2N/Ubc13, ITCH, RNF11 and TAX1BP1 and prevents prolonged TRAF-2 ubiquitination (By similarity). Interacts with TAX1BP1 in response to TNF stimulation; the interaction promotes TRAF2 dissociation from UBE2N/Ubc13 and TNFAIP3/A20, and prevents prolonged TRAF-2 ubiquitination (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (PubMed:15121867). Interacts with deubiquitinating enzyme USP48 (PubMed:16214042). Interacts with PTPN2; probably involved in TNF-mediated signaling (PubMed:15696169). Interacts with Toll-like receptor TLR4/3 adapter TICAM1/TRIF; the interaction may promote TICAM1 ubiquitination (PubMed:20047764). Interacts with kinase/endoribonuclease ERN1/IRE1 and DAB2IP in response to ER stress; the interaction requires DAB2IP (By similarity). Interacts with ERN1/IRE1 and TAOK3 in response to ER stress; the interaction may promote TRAF2 phosphorylation (PubMed:11278723). Interacts (via zinc fingers) with DAB2IP (via C-terminus PER domain)in response to TNF stimulation (PubMed:15310755, PubMed:17389591). Interacts with CASP8AP2/FLASH (By similarity). Interacts with NFATC2IP; the interaction may repress IL-4 production in T cells (By similarity). Interacts with kinase CDK9 (PubMed:9827693). Interacts with sphingosine kinase 1 SPHK1 (PubMed:20577214). Interacts with kinase TNIK (PubMed:10521462). Interacts with TRAFD1 (By similarity). Interacts with DNA phosphodiesterase TDP2 (PubMed:10764746). Interacts with MAVS/IPS1 (PubMed:16153868). Interacts with CARD14 (PubMed:21302310). Interacts with Epstein-Barr virus LMP1/BNFL1 (PubMed:10411888). Interacts with GPS2 (By similarity). Interacts with XPNPEP3 (PubMed:25609706). Interacts with RIPK3 (PubMed:29883609). Interacts with RELL2 (PubMed:19969290). Interacts with LRRC19 (PubMed:25026888). Interacts with GAPDH; promoting TRAF2 ubiquitination (PubMed:23332158)

geneName: AASDHPPT

geneName: ARSJ

value: The coiled coil domain mediates homo- and hetero-oligomerization

value: The MATH/TRAF domain binds to receptor cytoplasmic domains

value: The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling

value: Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linked polyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B

value: Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via 'Lys-48'-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Ubiquitination is inhibited by LRRC19; inhibits proteasomal degradation (PubMed:25026888). Ubiquitinated at Lys-320 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity). Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO7; leading to repression of NF-kappa-B signaling (PubMed:22212761)

value: Belongs to the TNF receptor-associated factor family. A subfamily

value: Was reported to interact with IL15RA (PubMed:10463949). However, this work was later retracted (PubMed:21357251)

description: Removed

description: TNF receptor-associated factor 2

description: MATH

description: RING-type

description: TRAF-type 1

description: TRAF-type 2

description: Important for interaction with BIRC2 and BIRC3

description: N-acetylalanine

description: Phosphoserine

description: Phosphothreonine

description: Phosphoserine

description: Phosphothreonine

description: Phosphothreonine; by PKC

description: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

description: in isoform 3

description: in isoform 2

description: in isoform 4

description: Reduces global phosphorylation. Partial reduction of TNF-dependent activation of NF-kappa-B and activation of JNK.

description: Slight increase of TNF-dependent activation of NF-kappa-B and activation of JNK.

description: Abolishes 'Lys-63'-linked polyubiquitination.

description: Loss of phosphorylation site. Abolishes activation of NF-kappa-B.

description: Strongly reduced interaction with BIRC3.

description: in Ref. 2; BAB70792

description: in Ref. 1; AAA87706

title: Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.

referencePositions:
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
INTERACTION WITH TNFRSF1B/TNFR2

authors:
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
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Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
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Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.
Ohara O.
Isogai T.
Sugano S.

title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)

authors:
Bechtel S.
Rosenfelder H.
Duda A.
Schmidt C.P.
Ernst U.
Wellenreuther R.
Mehrle A.
Schuster C.
Bahr A.
Bloecker H.
Heubner D.
Hoerlein A.
Michel G.
Wedler H.
Koehrer K.
Ottenwaelder B.
Poustka A.
Wiemann S.
Schupp I.

title: The full-ORF clone resource of the German cDNA consortium.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)

authoringGroup: SeattleSNPs variation discovery resource

authors:
Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.S.
Babbage A.K.
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Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.R.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.I.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.M.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

title: DNA sequence and analysis of human chromosome 9.

authors:
Mural R.J.
Istrail S.
Sutton G.G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.

title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

authors:
Rothe M.
Wong S.C.
Henzel W.J.
Goeddel D.V.

title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

referencePositions:
NUCLEOTIDE SEQUENCE [MRNA] OF 201-501
INTERACTION WITH TRAF1 AND TNFRSF1B

title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

authors:
Rothe M.
Xiong J.
Shu H.-B.
Williamson K.
Goddard A.
Goeddel D.V.

title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

authors:
Hsu H.
Solovyev I.
Colombero A.
Elliott R.
Kelley M.
Boyle W.J.

title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.

title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.

referencePositions: IDENTIFICATION IN A COMPLEX WITH TNFRSF8; TNFRSF1B

authors:
Malinin N.L.
Boldin M.P.
Kovalenko A.V.
Wallach D.

title: MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

authors:
Pullen S.S.
Miller H.G.
Everdeen D.S.
Dang T.T.
Crute J.J.
Kehry M.R.

title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

authors:
Thome M.
Hofmann K.
Burns K.
Martinon F.
Bodmer J.-L.
Mattmann C.
Tschopp J.

title: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

authors:
Gravestein L.A.
Amsen D.
Boes M.
Calvo C.R.
Kruisbeek A.M.
Borst J.

title: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.

authors:
Kawamata S.
Hori T.
Imura A.
Takaori-Kondo A.
Uchiyama T.

title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.

authors:
Wong B.R.
Josien R.
Lee S.Y.
Vologodskaia M.
Steinman R.M.
Choi Y.

title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

authors:
MacLachlan T.K.
Sang N.
De Luca A.
Puri P.L.
Levrero M.
Giordano A.

title: Binding of CDK9 to TRAF2.

authors:
Saoulli K.
Lee S.Y.
Cannons J.L.
Yeh W.C.
Santana A.
Goldstein M.D.
Bangia N.
DeBenedette M.A.
Mak T.W.
Choi Y.
Watts T.H.

title: CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.

authors:
Nishitoh H.
Saitoh M.
Mochida Y.
Takeda K.
Nakano H.
Rothe M.
Miyazono K.
Ichijo H.

title: ASK1 is essential for JNK/SAPK activation by TRAF2.

title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

title: NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.

referencePositions: IDENTIFICATION IN A COMPLEX WITH TBK1 AND TANK

authors:
Bulfone-Paus S.
Bulanova E.
Pohl T.
Budagian V.
Duerkop H.
Rueckert R.
Kunzendorf U.
Paus R.
Krause H.

title: Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain.

authors:
Baud V.
Liu Z.-G.
Bennett B.
Suzuki N.
Xia Y.
Karin M.

title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.

authors:
Kwon B.
Yu K.-Y.
Ni J.
Yu G.-L.
Jang I.-K.
Kim Y.-J.
Xing L.
Liu D.
Wang S.-X.
Kwon B.S.

title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.

authors:
Ye X.
Mehlen P.
Rabizadeh S.
VanArsdale T.
Zhang H.
Shin H.
Wang J.J.L.
Leo E.
Zapata J.M.
Hauser C.A.
Reed J.C.
Bredesen D.E.

title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

authors:
Fu C.A.
Shen M.
Huang B.C.
Lasaga J.
Payan D.G.
Luo Y.

title: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.

authors:
Eby M.T.
Jasmin A.
Kumar A.
Sharma K.
Chaudhary P.M.

title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.

authors:
Pype S.
Declercq W.
Ibrahimi A.
Michiels C.
Van Rietschoten J.G.I.
Dewulf N.
de Boer M.
Vandenabeele P.
Huylebroeck D.
Remacle J.E.

title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

authors:
Xia X.-Z.
Treanor J.
Senaldi G.
Khare S.D.
Boone T.
Kelley M.
Theill L.E.
Colombero A.
Solovyev I.
Lee F.
McCabe S.
Elliott R.
Miner K.
Hawkins N.
Guo J.
Stolina M.
Yu G.
Wang J.
Delaney J.
Meng S.-Y.
Boyle W.J.
Hsu H.

title: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.

authors:
Kumar A.
Eby M.T.
Sinha S.
Jasmin A.
Chaudhary P.M.

title: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.

authors:
Yoneda T.
Imaizumi K.
Oono K.
Yui D.
Gomi F.
Katayama T.
Tohyama M.

title: Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.

authors:
Habelhah H.
Frew I.J.
Laine A.
Janes P.W.
Relaix F.
Sassoon D.
Bowtell D.D.L.
Ronai Z.

title: Stress-induced decrease in TRAF2 stability is mediated by Siah2.

title: Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

title: TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.

referencePositions:
FUNCTION
INTERACTION WITH BIRC2 AND BIRC3
UBIQUITINATION BY BIRC2
DEGRADATION

authors:
Trompouki E.
Hatzivassiliou E.
Tsichritzis T.
Farmer H.
Ashworth A.
Mosialos G.

title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

referencePositions:
FUNCTION
UBIQUITINATION
DEUBIQUITINATION BY CYLD

authors:
Kovalenko A.
Chable-Bessia C.
Cantarella G.
Israeel A.
Wallach D.
Courtois G.

title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

referencePositions:
INTERACTION WITH CYLD
UBIQUITINATION
DEUBIQUITINATION BY CYLD

authors:
Zhang H.
Zhang R.
Luo Y.
D'Alessio A.
Pober J.S.
Min W.

title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

title: TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.

referencePositions:
FUNCTION
SUBCELLULAR LOCATION
INTERACTION WITH TRAF3
SUBUNIT

authors:
Gil J.
Garcia M.A.
Gomez-Puertas P.
Guerra S.
Rullas J.
Nakano H.
Alcami J.
Esteban M.

title: TRAF family proteins link PKR with NF-kappa B activation.

authors:
Xu L.-G.
Wang Y.-Y.
Han K.-J.
Li L.-Y.
Zhai Z.
Shu H.-B.

title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.

authors:
Reiley W.
Zhang M.
Wu X.
Granger E.
Sun S.C.

title: Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.

authors:
van Vliet C.
Bukczynska P.E.
Puryer M.A.
Sadek C.M.
Shields B.J.
Tremblay M.L.
Tiganis T.

title: Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.

authors:
Tzimas C.
Michailidou G.
Arsenakis M.
Kieff E.
Mosialos G.
Hatzivassiliou E.G.

title: Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.

title: RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.

authors:
Gauci S.
Helbig A.O.
Slijper M.
Krijgsveld J.
Heck A.J.
Mohammed S.

title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

referencePositions: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2

referencePositions: CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]

title: Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.

title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.

referencePositions: INTERACTION WITH IKKA; IKKB; TAB2 AND TAB3

authors:
Blackwell K.
Zhang L.
Thomas G.S.
Sun S.
Nakano H.
Habelhah H.

title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.

referencePositions: IDENTIFICATION IN A COMPLEX WITH TNFRSF1A; RIPK1 AND IKKB

authors:
Cusick J.K.
Mustian A.
Goldberg K.
Reyland M.E.

title: RELT induces cellular death in HEK 293 epithelial cells.

authors:
Sondarva G.
Kundu C.N.
Mehrotra S.
Mishra R.
Rangasamy V.
Sathyanarayana P.
Ray R.S.
Rana B.
Rana A.

title: TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.

authors:
Mace P.D.
Smits C.
Vaux D.L.
Silke J.
Day C.L.

title: Asymmetric recruitment of cIAPs by TRAF2.

referencePositions:
INTERACTION WITH BIRC2
SUBUNIT
HOMOTRIMERIZATION

authors:
Zhang L.
Blackwell K.
Shi Z.
Habelhah H.

title: The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

authors:
Li S.
Lu K.
Wang J.
An L.
Yang G.
Chen H.
Cui Y.
Yin X.
Xie P.
Xing G.
He F.
Zhang L.

title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

authors:
Sasai M.
Tatematsu M.
Oshiumi H.
Funami K.
Matsumoto M.
Hatakeyama S.
Seya T.

title: Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.

authors:
Alvarez S.E.
Harikumar K.B.
Hait N.C.
Allegood J.
Strub G.M.
Kim E.Y.
Maceyka M.
Jiang H.
Luo C.
Kordula T.
Milstien S.
Spiegel S.

title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

referencePositions:
FUNCTION
CATALYTIC ACTIVITY
ACTIVITY REGULATION
UBIQUITINATION
INTERACTION WITH SPHK1
SPHINGOLIPID BINDING

authors:
Olsen J.V.
Vermeulen M.
Santamaria A.
Kumar C.
Miller M.L.
Jensen L.J.
Gnad F.
Cox J.
Jensen T.S.
Nigg E.A.
Brunak S.
Mann M.

title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

authors:
Burkard T.R.
Planyavsky M.
Kaupe I.
Breitwieser F.P.
Buerckstuemmer T.
Bennett K.L.
Superti-Furga G.
Colinge J.

title: Initial characterization of the human central proteome.

authors:
Huang Y.
Chen L.
Zhou Y.
Liu H.
Yang J.
Liu Z.
Wang C.

title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.

referencePositions:
IDENTIFICATION IN APOPTOTIC COMPLEX I
INTERACTION WITH UXT

authors:
Scudiero I.
Zotti T.
Ferravante A.
Vessichelli M.
Vito P.
Stilo R.

title: Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.

authors:
Rigbolt K.T.
Prokhorova T.A.
Akimov V.
Henningsen J.
Johansen P.T.
Kratchmarova I.
Kassem M.
Mann M.
Olsen J.V.
Blagoev B.

title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7; SER-11 AND THR-22

authors:
Kuiken H.J.
Egan D.A.
Laman H.
Bernards R.
Beijersbergen R.L.
Dirac A.M.

title: Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

authors:
Cho J.H.
Lee M.K.
Yoon K.W.
Lee J.
Cho S.G.
Choi E.J.

title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.

authors:
Zhou A.Y.
Shen R.R.
Kim E.
Lock Y.J.
Xu M.
Chen Z.J.
Hahn W.C.

title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

authors:
Zhou H.
Di Palma S.
Preisinger C.
Peng M.
Polat A.N.
Heck A.J.
Mohammed S.

title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; THR-7 AND SER-11

authors:
Gao X.
Wang X.
Pham T.H.
Feuerbacher L.A.
Lubos M.L.
Huang M.
Olsen R.
Mushegian A.
Slawson C.
Hardwidge P.R.

title: NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation.

authors:
Su X.
Min S.
Cao S.
Yan H.
Zhao Y.
Li H.
Chai L.
Mei S.
Yang J.
Zhang Y.
Zhang Z.
Liu F.
Sun W.
Che Y.
Yang R.

title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.

authors:
Inoue M.
Kamada H.
Abe Y.
Higashisaka K.
Nagano K.
Mukai Y.
Yoshioka Y.
Tsutsumi Y.
Tsunoda S.

title: Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

authors:
Wang B.
Jie Z.
Joo D.
Ordureau A.
Liu P.
Gan W.
Guo J.
Zhang J.
North B.J.
Dai X.
Cheng X.
Bian X.
Zhang L.
Harper J.W.
Sun S.C.
Wei W.

title: TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.

authors:
Choi S.W.
Park H.H.
Kim S.
Chung J.M.
Noh H.J.
Kim S.K.
Song H.K.
Lee C.W.
Morgan M.J.
Kang H.C.
Kim Y.S.

title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

authors:
Jaeger-Ruckstuhl C.A.
Lo Y.
Fulton E.
Waltner O.G.
Shabaneh T.B.
Simon S.
Muthuraman P.V.
Correnti C.E.
Newsom O.J.
Engstrom I.A.
Kanaan S.B.
Bhise S.S.
Peralta J.M.C.
Ruff R.
Price J.P.
Stull S.M.
Stevens A.R.
Bugos G.
Kluesner M.G.
Voillet V.
Muhunthan V.
Morrish F.
Olson J.M.
Gottardo R.
Sarthy J.F.
Henikoff S.
Sullivan L.B.
Furlan S.N.
Riddell S.R.

title: Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.

authors:
Park Y.C.
Burkitt V.
Villa A.R.
Tong L.
Wu H.

title: Structural basis for self-association and receptor recognition of human TRAF2.

referencePositions: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 310-501 IN COMPLEX WITH TNFRSF1B

authors:
McWhirter S.M.
Pullen S.S.
Holton J.M.
Crute J.J.
Kehry M.R.
Alber T.

title: Crystallographic analysis of CD40 recognition and signaling by human TRAF2.

referencePositions: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH EBV BNFL1

referencePositions: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 315-501 IN COMPLEX WITH TNFRSF5

referencePositions: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF4

referencePositions: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF9

authors:
Park Y.C.
Ye H.
Hsia C.
Segal D.
Rich R.L.
Liou H.C.
Myszka D.G.
Wu H.

title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.

referencePositions: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 331-501 IN COMPLEX WITH TRADD

title: Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

referencePositions: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-133

authors:
Zheng C.
Kabaleeswaran V.
Wang Y.
Cheng G.
Wu H.

title: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.

referencePositions: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 266-330 IN COMPLEXES WITH TRAF1 AND BIRC3

referencePositions: MUTAGENESIS OF ILE-285; VAL-288 AND GLU-292

value: sTNF-TNR1A receptor-ligand core complex, BIRC3 variant

value: mTNF-TNR1A receptor-ligand core complex, BIRC3 variant

value: mTNF-TNR1B receptor-ligand core complex, BIRC3 variant

value: sTNF-TNR1A receptor-ligand core complex, BIRC2 variant

value: mTNF-TNR1A receptor-ligand core complex, BIRC2 variant

value: mTNF-TNR1B receptor-ligand core complex, BIRC2 variant

value: 7 GO annotations based on evolutionary models

value: Caspase activation via Death Receptors in the presence of ligand

value: TNFR1-induced NF-kappa-B signaling pathway

value: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

value: Defective RIPK1-mediated regulated necrosis

value: Expressed in lower esophagus mucosa and 123 other cell types or tissues

value: C:tumor necrosis factor receptor superfamily complex

value: F:mitogen-activated protein kinase kinase kinase binding

value: F:tumor necrosis factor receptor binding

value: P:canonical NF-kappaB signal transduction

value: P:extrinsic apoptotic signaling pathway via death domain receptors

value: P:intrinsic apoptotic signaling pathway in response to DNA damage

value: P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

value: P:negative regulation of glial cell apoptotic process

value: P:non-canonical NF-kappaB signal transduction

value: P:positive regulation of canonical NF-kappaB signal transduction

value: P:positive regulation of extrinsic apoptotic signaling pathway

value: P:positive regulation of interleukin-2 production

value: P:positive regulation of JUN kinase activity

value: P:positive regulation of pyroptotic inflammatory response

value: P:positive regulation of T cell cytokine production

value: P:positive regulation of tumor necrosis factor-mediated signaling pathway

value: P:regulation of protein-containing complex assembly

value: P:response to endoplasmic reticulum stress

value: P:tumor necrosis factor-mediated signaling pathway

value: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A

value: Zinc/RING finger domain, C3HC4 (zinc finger)


entryType: UniProtKB reviewed (Swiss-Prot)

scientificName: Homo sapiens

commonName: Human

lineage: Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

proteinExistence: 1: Evidence at protein level

value: Protein EFR3 homolog A

value: Protein EFR3-like

source: PubMed

value: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825)

commentType: FUNCTION

value: Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2) (PubMed:26571211)

commentType: SUBUNIT

commentType: SUBCELLULAR LOCATION

value: Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825, PubMed:26571211). A small amount is observed in the cytosol (PubMed:25380825)

value: Cell membrane

value: Lipid-anchor

value: Cytoplasm, cytosol

commentType: ALTERNATIVE PRODUCTS

isoformSequenceStatus: Displayed

isoformSequenceStatus: Described

value: Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane

commentType: PTM

commentType: DISEASE

value: Genetic variations in EFR3A may be associated with susceptibility to autism

value: Belongs to the EFR3 family

commentType: SIMILARITY

commentType: SEQUENCE CAUTION

sequenceCautionType: Erroneous initiation

note: Extended N-terminus.

sequenceCautionType: Miscellaneous discrepancy

note: Contaminating sequence. Potential poly-A sequence.

type: Chain

modifier: EXACT

description: Protein EFR3 homolog A

type: Modified residue

description: Phosphoserine

source: UniProtKB

description: Phosphoserine

description: Phosphoserine

description: Phosphoserine

type: Alternative sequence

description: in isoform 2

description: in isoform 3

type: Natural variant

originalSequence: P

originalSequence: K

description: in dbSNP:rs749463078

database: dbSNP

originalSequence: G

description: in dbSNP:rs1212454955

originalSequence: R

description: in dbSNP:rs1818455073

description: in dbSNP:rs1323253445

description: in dbSNP:rs780864616

description: in dbSNP:rs1818959817

description: in dbSNP:rs774959333

description: in dbSNP:rs1395349665

description: in dbSNP:rs754610866

description: in dbSNP:rs2270877

description: in dbSNP:rs1051221

description: in dbSNP:rs770980074

description: in dbSNP:rs1820754943

description: in dbSNP:rs779475356

description: in dbSNP:rs374094815

description: in dbSNP:rs759848268

description: in dbSNP:rs1467962026

description: Induces localization to the cytosol.

description: in Ref. 2; CAH56143

description: in Ref. 2; CAH56143

authors:
Nagase T.
Seki N.
Tanaka A.
Ishikawa K.
Nomura N.

title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)

authors:
Bechtel S.
Rosenfelder H.
Duda A.
Schmidt C.P.
Ernst U.
Wellenreuther R.
Mehrle A.
Schuster C.
Bahr A.
Bloecker H.
Heubner D.
Hoerlein A.
Michel G.
Wedler H.
Koehrer K.
Ottenwaelder B.
Poustka A.
Wiemann S.
Schupp I.

title: The full-ORF clone resource of the German cDNA consortium.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-821 (ISOFORM 3)

authors:
Nusbaum C.
Mikkelsen T.S.
Zody M.C.
Asakawa S.
Taudien S.
Garber M.
Kodira C.D.
Schueler M.G.
Shimizu A.
Whittaker C.A.
Chang J.L.
Cuomo C.A.
Dewar K.
FitzGerald M.G.
Yang X.
Allen N.R.
Anderson S.
Asakawa T.
Blechschmidt K.
Bloom T.
Borowsky M.L.
Butler J.
Cook A.
Corum B.
DeArellano K.
DeCaprio D.
Dooley K.T.
Dorris L. III
Engels R.
Gloeckner G.
Hafez N.
Hagopian D.S.
Hall J.L.
Ishikawa S.K.
Jaffe D.B.
Kamat A.
Kudoh J.
Lehmann R.
Lokitsang T.
Macdonald P.
Major J.E.
Matthews C.D.
Mauceli E.
Menzel U.
Mihalev A.H.
Minoshima S.
Murayama Y.
Naylor J.W.
Nicol R.
Nguyen C.
O'Leary S.B.
O'Neill K.
Parker S.C.J.
Polley A.
Raymond C.K.
Reichwald K.
Rodriguez J.
Sasaki T.
Schilhabel M.
Siddiqui R.
Smith C.L.
Sneddon T.P.
Talamas J.A.
Tenzin P.
Topham K.
Venkataraman V.
Wen G.
Yamazaki S.
Young S.K.
Zeng Q.
Zimmer A.R.
Rosenthal A.
Birren B.W.
Platzer M.
Shimizu N.
Lander E.S.

title: DNA sequence and analysis of human chromosome 8.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

authors:
Cantin G.T.
Yi W.
Lu B.
Park S.K.
Xu T.
Lee J.-D.
Yates J.R. III

title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694

referencePositions: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

authors:
Daub H.
Olsen J.V.
Bairlein M.
Gnad F.
Oppermann F.S.
Korner R.
Greff Z.
Keri G.
Stemmann O.
Mann M.

title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422

authors:
Dephoure N.
Zhou C.
Villen J.
Beausoleil S.A.
Bakalarski C.E.
Elledge S.J.
Gygi S.P.

title: A quantitative atlas of mitotic phosphorylation.

authors:
Olsen J.V.
Vermeulen M.
Santamaria A.
Kumar C.
Miller M.L.
Jensen L.J.
Gnad F.
Cox J.
Jensen T.S.
Nigg E.A.
Brunak S.
Mann M.

title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

authors:
Nakatsu F.
Baskin J.M.
Chung J.
Tanner L.B.
Shui G.
Lee S.Y.
Pirruccello M.
Hao M.
Ingolia N.T.
Wenk M.R.
De Camilli P.

title: PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity.

referencePositions:
FUNCTION
SUBCELLULAR LOCATION
PALMITOYLATION
MUTAGENESIS OF 6-CYS--CYS-9

authors:
Gupta A.R.
Pirruccello M.
Cheng F.
Kang H.J.
Fernandez T.V.
Baskin J.M.
Choi M.
Liu L.
Ercan-Sencicek A.G.
Murdoch J.D.
Klei L.
Neale B.M.
Franjic D.
Daly M.J.
Lifton R.P.
De Camilli P.
Zhao H.
Sestan N.
State M.W.

title: Rare deleterious mutations of the gene EFR3A in autism spectrum disorders.

authors:
Chung J.
Nakatsu F.
Baskin J.M.
De Camilli P.

title: Plasticity of PI4KIIIalpha interactions at the plasma membrane.

authors:
Bojjireddy N.
Guzman-Hernandez M.L.
Reinhard N.R.
Jovic M.
Balla T.

title: EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors.

authors:
Baskin J.M.
Wu X.
Christiano R.
Oh M.S.
Schauder C.M.
Gazzerro E.
Messa M.
Baldassari S.
Assereto S.
Biancheri R.
Zara F.
Minetti C.
Raimondi A.
Simons M.
Walther T.C.
Reinisch K.M.
De Camilli P.

title: The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.

referencePositions:
FUNCTION
IDENTIFICATION IN THE PI4K COMPLEX

value: 2 GO annotations based on evolutionary models

value: Presynaptic clusters and postsynaptic densities

value: Expressed in choroid plexus epithelium and 207 other cell types or tissues

value: P:phosphatidylinositol phosphate biosynthetic process

value: P:protein localization to plasma membrane


value: Astrocytic phosphoprotein PEA-15

value: 15 kDa phosphoprotein enriched in astrocytes

value: Phosphoprotein enriched in diabetes

value: PED

value: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface

value: Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD

commentType: INTERACTION

value: Associated with microtubules

value: Cytoplasm

value: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls

commentType: TISSUE SPECIFICITY

value: Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones

commentType: WEB RESOURCE

resourceName: Atlas of Genetics and Cytogenetics in Oncology and Haematology

description: Astrocytic phosphoprotein PEA-15

type: Domain

description: DED

source: PROSITE-ProRule

type: Region

description: Microtubule-binding

description: Microtubule-binding

description: Phosphoserine

description: Phosphoserine

description: Phosphoserine

description: Phosphoserine

description: in isoform 2

originalSequence: M

type: Sequence conflict

description: in Ref. 1; CAA60499

originalSequence: A

description: in Ref. 1; CAA60499

originalSequence: L

description: in Ref. 1; CAA60499

originalSequence: Y

description: in Ref. 1; CAA60499

type: Helix

source: PDB

type: Turn

authors:
Estelles A.
Yokoyama M.
Nothias F.
Vincent J.-D.
Glowinski J.
Vernier P.
Chneiweiss H.

title: The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human.

authors:
Condorelli G.
Vigliotta G.
Iavarone C.
Caruso M.
Tocchetti C.G.
Andreozzi F.
Cafieri A.
Tecce M.F.
Formisano P.
Beguinot L.
Beguinot F.

title: PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.

referencePositions:
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
FUNCTION
TISSUE SPECIFICITY

authors:
Wolford J.K.
Bogardus C.
Ossowski V.
Prochazka M.

title: Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians.

authors:
Mural R.J.
Istrail S.
Sutton G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.

authors:
Kalnine N.
Chen X.
Rolfs A.
Halleck A.
Hines L.
Eisenstein S.
Koundinya M.
Raphael J.
Moreira D.
Kelley T.
LaBaer J.
Lin Y.
Phelan M.
Farmer A.

title: Cloning of human full-length CDSs in BD Creator(TM) system donor vector.

authors:
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.
Ohara O.
Isogai T.
Sugano S.

title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

authors:
Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.A.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.S.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.J.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.I.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.W.
McLaren S.
Milne S.
Mistry S.
Moore M.J.F.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.M.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.

title: The DNA sequence and biological annotation of human chromosome 1.

referencePositions:
PROTEIN SEQUENCE OF 55-83 AND 89-98
IDENTIFICATION BY MASS SPECTROMETRY

authors:
Condorelli G.
Vigliotta G.
Cafieri A.
Trencia A.
Andalo P.
Oriente F.
Miele C.
Caruso M.
Formisano P.
Beguinot F.

title: PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.

referencePositions:
FUNCTION
INTERACTION WITH CASP8 AND FADD

authors:
Olsen J.V.
Blagoev B.
Gnad F.
Macek B.
Kumar C.
Mortensen P.
Mann M.

title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 AND SER-116

authors:
Gauci S.
Helbig A.O.
Slijper M.
Krijgsveld J.
Heck A.J.
Mohammed S.

title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-116

authors:
Burkard T.R.
Planyavsky M.
Kaupe I.
Breitwieser F.P.
Buerckstuemmer T.
Bennett K.L.
Superti-Furga G.
Colinge J.

title: Initial characterization of the human central proteome.

authors:
Rigbolt K.T.
Prokhorova T.A.
Akimov V.
Henningsen J.
Johansen P.T.
Kratchmarova I.
Kassem M.
Mann M.
Olsen J.V.
Blagoev B.

title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

authors:
Zhou H.
Di Palma S.
Preisinger C.
Peng M.
Polat A.N.
Heck A.J.
Mohammed S.

title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

authors:
Bian Y.
Song C.
Cheng K.
Dong M.
Wang F.
Huang J.
Sun D.
Wang L.
Ye M.
Zou H.

title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116

value: 1 GO annotation based on evolutionary models

value: Expressed in dorsal motor nucleus of vagus nerve and 211 other cell types or tissues

value: P:negative regulation of D-glucose import across plasma membrane

value: P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

value: astrocytic phosphoprotein PEA-15 isoform X1


entryType: UniProtKB unreviewed (TrEMBL)

scientificName: Caenorhabditis elegans

source: EMBL

source: Proteomes

lineage: Eukaryota Metazoa Ecdysozoa Nematoda Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis

proteinExistence: 4: Predicted

value: Serpin domain-containing protein

source: WormBase

description: Serpin

source: Pfam

Reference proteome

category: Technical term

citationType: journal article

authors:
Sulson J.E.
Waterston R.

database: PubMed

database: DOI

title: Genome sequence of the nematode C. elegans: a platform for investigating biology.

journal: Science

value: Bristol N2

type: STRAIN

database: EMBL

key: ProteinId

key: Status

key: MoleculeType

database: PIR

key: EntryName

database: RefSeq

key: NucleotideSequenceId

database: AlphaFoldDB

key: Description

database: SMR

database: FunCoup

key: Number of interactors

database: STRING

database: PaxDb

database: GeneID

database: KEGG

database: UCSC

key: OrganismName

value: c. elegans

database: AGR

database: CTD

database: WormBase

key: GeneId

key: GeneName

database: eggNOG

key: ToxonomicScope

value: Eukaryota

database: HOGENOM

database: InParanoid

database: OMA

key: Fingerprint

database: OrthoDB

database: PhylomeDB

database: Reactome

key: PathwayName

value: Platelet degranulation

value: Collagen biosynthesis and modifying enzymes

value: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

value: Neutrophil degranulation

value: Dissolution of Fibrin Clot

value: Regulation of FXIIa and plasma kallikrein activity

value: CASP4 inflammasome assembly

database: Proteomes

key: Component

value: Chromosome X

database: Bgee

key: ExpressionPatterns

value: Expressed in adult organism


scientificName: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

lineage: Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora

proteinExistence: 3: Inferred from homology

value: Hexose transporter HXT13

source: ARBA

value: Membrane

value: Multi-pass membrane protein

source: RuleBase

value: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family

type: Transmembrane

description: Helical

source: SAM

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Major facilitator superfamily (MFS) profile

source: PROSITE

description: Disordered

type: Compositional bias

description: Polar residues

Membrane

category: Cellular component

Transmembrane

category: Domain

Transport

category: Biological process

authors:
Galagan J.E.
Calvo S.E.
Borkovich K.A.
Selker E.U.
Read N.D.
Jaffe D.
FitzHugh W.
Ma L.J.
Smirnov S.
Purcell S.
Rehman B.
Elkins T.
Engels R.
Wang S.
Nielsen C.B.
Butler J.
Endrizzi M.
Qui D.
Ianakiev P.
Bell-Pedersen D.
Nelson M.A.
Werner-Washburne M.
Selitrennikoff C.P.
Kinsey J.A.
Braun E.L.
Zelter A.
Schulte U.
Kothe G.O.
Jedd G.
Mewes W.
Staben C.
Marcotte E.
Greenberg D.
Roy A.
Foley K.
Naylor J.
Stange-Thomann N.
Barrett R.
Gnerre S.
Kamal M.
Kamvysselis M.
Mauceli E.
Bielke C.
Rudd S.
Frishman D.
Krystofova S.
Rasmussen C.
Metzenberg R.L.
Perkins D.D.
Kroken S.
Cogoni C.
Macino G.
Catcheside D.
Li W.
Pratt R.J.
Osmani S.A.
DeSouza C.P.
Glass L.
Orbach M.J.
Berglund J.A.
Voelker R.
Yarden O.
Plamann M.
Seiler S.
Dunlap J.
Radford A.
Aramayo R.
Natvig D.O.
Alex L.A.
Mannhaupt G.
Ebbole D.J.
Freitag M.
Paulsen I.
Sachs M.S.
Lander E.S.
Nusbaum C.
Birren B.

database: PubMed

database: DOI

title: The genome sequence of the filamentous fungus Neurospora crassa.

journal: Nature

database: EMBL

value: MFS general substrate transporter like domains


source: Google

value: DNA-directed RNA polymerase III RPC4

value: Nucleus

description: Disordered

description: Disordered

description: Disordered

description: Low complexity

description: Basic and acidic residues

description: Basic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Acidic residues

database: RefSeq

database: AlphaFoldDB

database: FunCoup

database: STRING

database: PaxDb

database: GeneID

database: KEGG

database: VEuPathDB

value: Chromosome 2, Linkage Group V

database: GO

key: GoTerm

value: C:RNA polymerase III complex

key: GoEvidenceType

value: F:DNA binding

value: P:tRNA transcription by RNA polymerase III

value: DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4


value: SUMO-conjugating enzyme UBC9

value: Ubiquitin carrier protein 9

value: Ubiquitin-conjugating enzyme E2-18 kDa

value: Protein modification; protein sumoylation

commentType: PATHWAY

value: Belongs to the ubiquitin-conjugating enzyme family

description: UBC core

type: Active site

description: Glycyl thioester intermediate

ATP-binding

category: Ligand

Transferase

category: Molecular function

key: ProteinId

database: SMR

database: HOGENOM

database: InParanoid

database: OMA

database: OrthoDB

value: C:SUMO ligase complex

value: F:ATP binding


scientificName: Schizosaccharomyces pombe (strain 972 / ATCC 24843)

commonName: Fission yeast

lineage: Eukaryota Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces

value: 60S ribosome subunit biogenesis protein nip7

value: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly

value: Interacts with pre-ribosome complex

value: Cytoplasm

value: Nucleus, nucleolus

value: Belongs to the NIP7 family

description: PUA

type: Beta strand

authors:
Wood V.
Gwilliam R.
Rajandream M.A.
Lyne M.H.
Lyne R.
Stewart A.
Sgouros J.G.
Peat N.
Hayles J.
Baker S.G.
Basham D.
Bowman S.
Brooks K.
Brown D.
Brown S.
Chillingworth T.
Churcher C.M.
Collins M.
Connor R.
Cronin A.
Davis P.
Feltwell T.
Fraser A.
Gentles S.
Goble A.
Hamlin N.
Harris D.E.
Hidalgo J.
Hodgson G.
Holroyd S.
Hornsby T.
Howarth S.
Huckle E.J.
Hunt S.
Jagels K.
James K.D.
Jones L.
Jones M.
Leather S.
McDonald S.
McLean J.
Mooney P.
Moule S.
Mungall K.L.
Murphy L.D.
Niblett D.
Odell C.
Oliver K.
O'Neil S.
Pearson D.
Quail M.A.
Rabbinowitsch E.
Rutherford K.M.
Rutter S.
Saunders D.
Seeger K.
Sharp S.
Skelton J.
Simmonds M.N.
Squares R.
Squares S.
Stevens K.
Taylor K.
Taylor R.G.
Tivey A.
Walsh S.V.
Warren T.
Whitehead S.
Woodward J.R.
Volckaert G.
Aert R.
Robben J.
Grymonprez B.
Weltjens I.
Vanstreels E.
Rieger M.
Schaefer M.
Mueller-Auer S.
Gabel C.
Fuchs M.
Duesterhoeft A.
Fritzc C.
Holzer E.
Moestl D.
Hilbert H.
Borzym K.
Langer I.
Beck A.
Lehrach H.
Reinhardt R.
Pohl T.M.
Eger P.
Zimmermann W.
Wedler H.
Wambutt R.
Purnelle B.
Goffeau A.
Cadieu E.
Dreano S.
Gloux S.
Lelaure V.
Mottier S.
Galibert F.
Aves S.J.
Xiang Z.
Hunt C.
Moore K.
Hurst S.M.
Lucas M.
Rochet M.
Gaillardin C.
Tallada V.A.
Garzon A.
Thode G.
Daga R.R.
Cruzado L.
Jimenez J.
Sanchez M.
del Rey F.
Benito J.
Dominguez A.
Revuelta J.L.
Moreno S.
Armstrong J.
Forsburg S.L.
Cerutti L.
Lowe T.
McCombie W.R.
Paulsen I.
Potashkin J.
Shpakovski G.V.
Ussery D.
Barrell B.G.
Nurse P.

title: The genome sequence of Schizosaccharomyces pombe.

authors:
Matsuyama A.
Arai R.
Yashiroda Y.
Shirai A.
Kamata A.
Sekido S.
Kobayashi Y.
Hashimoto A.
Hamamoto M.
Hiraoka Y.
Horinouchi S.
Yoshida M.

title: ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

referencePositions: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]

value: P:assembly of large subunit precursor of preribosome

value: 60S ribosome subunit biogenesis protein NIP7 homolog

value: CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7


scientificName: Aspergillus oryzae (strain ATCC 42149 / RIB 40)

commonName: Yellow koji mold

lineage: Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Aspergillus Circumdati

value: DNA, SC138

authors:
Machida M.
Asai K.
Sano M.
Tanaka T.
Kumagai T.
Terai G.
Kusumoto K.
Arima T.
Akita O.
Kashiwagi Y.
Abe K.
Gomi K.
Horiuchi H.
Kitamoto K.
Kobayashi T.
Takeuchi M.
Denning D.W.
Galagan J.E.
Nierman W.C.
Yu J.
Archer D.B.
Bennett J.W.
Bhatnagar D.
Cleveland T.E.
Fedorova N.D.
Gotoh O.
Horikawa H.
Hosoyama A.
Ichinomiya M.
Igarashi R.
Iwashita K.
Juvvadi P.R.
Kato M.
Kato Y.
Kin T.
Kokubun A.
Maeda H.
Maeyama N.
Maruyama J.
Nagasaki H.
Nakajima T.
Oda K.
Okada K.
Paulsen I.
Sakamoto K.
Sawano T.
Takahashi M.
Takase K.
Terabayashi Y.
Wortman J.R.
Yamada O.
Yamagata Y.
Anazawa H.
Hata Y.
Koide Y.
Komori T.
Koyama Y.
Minetoki T.
Suharnan S.
Tanaka A.
Isono K.
Kuhara S.
Ogasawara N.
Kikuchi H.

database: PubMed

title: Genome sequencing and analysis of Aspergillus oryzae.

key: Status

database: Proteomes

value: Chromosome 6

database: InterPro

database: SUPFAM

value: Chondroitin AC/alginate lyase

key: MatchStatus


scientificName: Drosophila melanogaster

commonName: Fruit fly

lineage: Eukaryota Metazoa Ecdysozoa Arthropoda Altocrustacea Allotriocarida Hexapoda Insecta Pterygota Neoptera Eumetabola Endopterygota Aparaglossata Panorpida Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora

source: FlyBase

geneName: ttk

type: Repeat

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: Disordered

description: Disordered

description: Basic residues

description: Low complexity

description: Polar residues

citationType: submission

authors:
Stapleton M.
Carlson J.
Chavez C.
Frise E.
George R.
Pacleb J.
Park S.
Wan K.
Yu C.
Celniker S.

submissionDatabase: EMBL/GenBank/DDBJ databases

value: Berkeley

database: EMBL

key: MoleculeType

value: mRNA

database: RefSeq

value: Expressed in multidendritic neuron (Drosophila) in post-embryonic organism and 244 other cell types or tissues

value: P:negative regulation of neuromuscular synaptic transmission

value: P:positive regulation of synaptic assembly at neuromuscular junction

value: ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN


scientificName: Danio rerio

commonName: Zebrafish

lineage: Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

proteinExistence: 2: Evidence at transcript level

value: Dicarbonyl/L-xylulose reductase

source: ZFIN

value: dcxr

value: Homotetramer

value: Belongs to the short-chain dehydrogenases/reductases (SDR) family

description: Proton acceptor

authoringGroup: NIH - Zebrafish Gene Collection (ZGC) project

value: Ovary

type: TISSUE

key: NucleotideSequenceId

database: AlphaFoldDB

database: STRING

database: PeptideAtlas

database: AGR

database: CTD

database: ZFIN

database: eggNOG

value: Eukaryota

database: GeneTree

database: Reactome

value: Formation of xylulose-5-phosphate

database: Bgee

value: Expressed in mature ovarian follicle and 26 other cell types or tissues

value: F:carbonyl reductase (NADPH) activity

value: F:L-xylulose reductase (NADPH) activity

value: P:glucose metabolic process

value: P:xylulose metabolic process

database: CDD

key: EntryName

database: FunFam

value: L-xylulose reductase

value: NAD(P)-binding Rossmann-like Domain


value: phosphoinositide 5-phosphatase

value: Synj

value: synaptojanin

value: synj

value: Synapse

value: Belongs to the synaptojanin family

value: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family

description: SAC

description: Disordered

description: Pro residues

description: Pro residues

description: Low complexity

description: Polar residues

description: Pro residues

description: Pro residues

authors:
Stapleton M.
Carlson J.
Chavez C.
Frise E.
George R.
Pacleb J.
Park S.
Wan K.
Yu C.
Rubin G.M.
Celniker S.

value: Berkeley

value: mRNA

key: Description

database: SMR

database: IntAct

key: Interactions

database: GlyGen

key: glycosylation

value: 1 site

database: PaxDb

database: GeneID

database: KEGG

database: UCSC

value: Synthesis of PIPs at the plasma membrane

value: Synthesis of IP2, IP, and Ins in the cytosol

value: Expressed in head capsule and 149 other cell types or tissues

value: F:phosphatidylinositol phosphate 5-phosphatase activity

value: P:clathrin-dependent synaptic vesicle endocytosis

value: P:maintenance of presynaptic active zone structure

value: P:negative regulation of smoothened signaling pathway

value: P:positive regulation of autophagosome assembly

value: P:regulation of synapse structure or activity


value: Olfactomedin-like protein 2A

flag: Precursor

value: Homodimer. Binds to heparin and chondroitin sulfate E

value: Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development

value: Secreted

value: In the kidney expressed only by podocytes, wherein they localize to major processes

value: Detected at the vesicle stage of developing glomeruli, expressed in invading endothelial cells in the glomerular cleft at the S-shaped stage and is later expressed only at the basal aspect of maturing podocytes

commentType: DEVELOPMENTAL STAGE

value: May be cleaved at Lys-295 after secretion

value: O-glycosylated but not N-glycosylated

type: Signal

description: Olfactomedin-like protein 2A

description: Olfactomedin-like

description: Disordered

description: Disordered

type: Coiled coil

description: Low complexity

description: Basic and acidic residues

description: Basic and acidic residues

description: Polar residues

description: Basic and acidic residues

description: Low complexity

type: Site

description: Cleavage

type: Disulfide bond

description: in isoform 3

description: in isoform 2

description: in isoform 3

originalSequence: ATGTGSKAQ

description: in dbSNP:rs7874348

database: dbSNP

originalSequence: T

description: in dbSNP:rs16927649

authors:
Clark H.F.
Gurney A.L.
Abaya E.
Baker K.
Baldwin D.T.
Brush J.
Chen J.
Chow B.
Chui C.
Crowley C.
Currell B.
Deuel B.
Dowd P.
Eaton D.
Foster J.S.
Grimaldi C.
Gu Q.
Hass P.E.
Heldens S.
Huang A.
Kim H.S.
Klimowski L.
Jin Y.
Johnson S.
Lee J.
Lewis L.
Liao D.
Mark M.R.
Robbie E.
Sanchez C.
Schoenfeld J.
Seshagiri S.
Simmons L.
Singh J.
Smith V.
Stinson J.
Vagts A.
Vandlen R.L.
Watanabe C.
Wieand D.
Woods K.
Xie M.-H.
Yansura D.G.
Yi S.
Yu G.
Yuan J.
Zhang M.
Zhang Z.
Goddard A.D.
Wood W.I.
Godowski P.J.
Gray A.M.

title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

authors:
Furutani Y.
Manabe R.
Tsutsui K.
Yamada T.
Sugimoto N.
Kawai J.
Hayashizaki Y.
Sekiguchi K.

title: Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening.

authors:
Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.S.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.R.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.I.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.M.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

title: DNA sequence and analysis of human chromosome 9.

authors:
Mural R.J.
Istrail S.
Sutton G.G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.

title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)

authors:
Sistani L.
Rodriguez P.Q.
Hultenby K.
Uhlen M.
Betsholtz C.
Jalanko H.
Tryggvason K.
Wernerson A.
Patrakka J.

title: Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.

referencePositions:
TISSUE SPECIFICITY
SUBCELLULAR LOCATION
DEVELOPMENTAL STAGE

value: Osteosarcoma (U2OS) cell map - C5212 (29 proteins)

value: 5 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (2 sites)

value: 2 GO annotations based on evolutionary models

value: Expressed in dorsal root ganglion and 167 other cell types or tissues


scientificName: Xenopus laevis

commonName: African clawed frog

lineage: Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus

value: Uap1-prov protein

source: Xenbase

value: Belongs to the UDPGP type 1 family

authoringGroup: NIH - Xenopus Gene Collection (XGC) project

value: Embryo

database: EMBL

value: mRNA

database: RefSeq

database: AlphaFoldDB

database: AGR

database: Xenbase

key: GeneName

database: OrthoDB

value: Expressed in egg cell and 19 other cell types or tissues

database: GO

value: UDP-N-acetylhexosamine pyrophosphorylase isoform X2

value: Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

database: InterPro

database: PANTHER

value: UDP- GLUCOSE PYROPHOSPHORYLASE

database: Pfam

value: UDPGP

database: SUPFAM

value: Nucleotide-diphospho-sugar transferases


value: Serine/threonine-protein phosphatase 4 regulatory subunit 4

value: Putative regulatory subunit of serine/threonine-protein phosphatase 4

value: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R4

value: Cytoplasm

type: Chain

description: HEAT 1

description: HEAT 2

description: HEAT 3

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Low complexity

description: Polar residues

description: Basic residues

type: Modified residue

description: Phosphoserine

description: Phosphothreonine

type: Alternative sequence

description: in isoform 2

originalSequence: EALHVAGVEMQLTAAMSFLTIL

description: in isoform 2

type: Mutagenesis

description: Abolishes interaction with PPP4C.

description: Diminishes interaction with PPP4C.

originalSequence: V

description: Abolishes interaction with PPP4C.

Alternative splicing

category: Coding sequence diversity

Phosphoprotein

category: PTM

authors:
Nagase T.
Kikuno R.
Nakayama M.
Hirosawa M.
Ohara O.

database: PubMed

database: DOI

title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

journal: DNA Res.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)

value: Brain

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)

authors:
Chen G.I.
Tisayakorn S.
Jorgensen C.
D'Ambrosio L.M.
Goudreault M.
Gingras A.-C.

title: PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.

referencePositions: IDENTIFICATION IN THE PPP4C-PPP4R4 COMPLEX

value: PPP4C-PPP4R4 protein phosphatase 4 complex

value: 3 GO annotations based on evolutionary models

value: Expressed in superior frontal gyrus and 95 other cell types or tissues

value: C:protein serine/threonine phosphatase complex

value: F:protein phosphatase inhibitor activity

value: F:protein phosphatase regulator activity

value: F:protein serine/threonine phosphatase inhibitor activity

value: PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4

value: SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4


value: Hairy and enhancer of split 6 (Drosophila)

value: Hairy-related 13.2

value: Nucleus

type: Domain

description: BHLH

description: Orange

type: Region

description: Disordered

description: Helix-loop-helix motif

description: Disordered

description: Basic and acidic residues

description: Low complexity

value: Embryo

authors:
Kawamura A.
Koshida S.
Hijikata H.
Sakaguchi T.
Kondoh H.
Takada S.

title: Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.

journal: Genes Dev.

value: mRNA

database: IntAct

database: GeneID

database: CTD

database: ZFIN

value: F:DNA-binding transcription factor activity, RNA polymerase II-specific

value: F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

value: P:negative regulation of DNA-templated transcription

value: P:negative regulation of transcription by RNA polymerase II

value: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED

value: HLH, helix-loop-helix DNA-binding domain


value: Aspartate--tRNA ligase, mitochondrial

value: Aspartyl-tRNA synthetase

value: AspRS

source: HGNC

value: Catalyzes the attachment of aspartate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)

commentType: CATALYTIC ACTIVITY

name: tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate

database: Rhea

database: ChEBI

value: Homodimer. Interacts with FBXO24 (PubMed:39039092)

geneName: CDIPT

geneName: CFTR

geneName: FETUB

geneName: GAPDHS

value: Mitochondrion matrix

value: Mitochondrion membrane

value: Acetylated; acetylation protects from ubiquitin-mediated degradation

value: Ubiquitinated by the SCF-FBXO24 E3 ubiquitin ligase, leading to proteasomal degradation

diseaseId: Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation

acronym: LBSL

description: Autosomal recessive disease and is defined on the basis of a highly characteristic constellation of abnormalities observed by magnetic resonance imaging and spectroscopy. Affected individuals develop slowly progressive cerebellar ataxia, spasticity, and dorsal column dysfunction, sometimes with a mild cognitive deficit or decline.

database: MIM

value: The disease is caused by variants affecting the gene represented in this entry

diseaseId: Charcot-Marie-Tooth disease, axonal, type 2LL

description: An autosomal recessive, axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2LL is characterized by childhood-onset progressive gait difficulties, distal muscle weakness and atrophy, and areflexia. Central nervous system involvement with impaired intellectual development and epilepsy may be present.

value: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily

type: Transit peptide

description: Mitochondrion

description: Aspartate--tRNA ligase, mitochondrial

description: Aspartate

type: Binding site

description: Phosphothreonine

description: Phosphoserine

description: in dbSNP:rs4427454

description: in LBSL; no effect on its mitochondrial localization; dbSNP:rs121918209

description: in LBSL; dbSNP:rs121918208

description: in LBSL; dbSNP:rs121918210

description: in LBSL; Significant impairment of its mitochondrial matrix localization; dbSNP:rs1469160736

description: in dbSNP:rs35515638

description: in CMT2LL; likely pathogenic

description: in LBSL; dbSNP:rs772489337

description: in LBSL; no effect on its mitochondrial localization; dbSNP:rs121918207

description: in CMT2LL; likely pathogenic

description: in CMT2LL; likely pathogenic; decreased aspartate-tRNA ligase activity

description: in LBSL; dbSNP:rs770525873

description: in LBSL; no effect on its mitochondrial localization; dbSNP:rs121918212

description: in LBSL; no effect on its mitochondrial localization; dbSNP:rs121918213

description: in LBSL; dbSNP:rs121918205

description: in LBSL; dbSNP:rs761675657

description: No effect on its mitochondria localization.

description: Displays low levels of polyubiquitylation.

description: Displays decreased acetylation and high-levels of polyubiquitylation.

authors:
Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.A.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.S.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.J.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.I.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.W.
McLaren S.
Milne S.
Mistry S.
Moore M.J.F.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.M.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.

title: The DNA sequence and biological annotation of human chromosome 1.

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

authors:
Bonnefond L.
Fender A.
Rudinger-Thirion J.
Giege R.
Florentz C.
Sissler M.

title: Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.

referencePositions:
SUBCELLULAR LOCATION
SUBUNIT
CATALYTIC ACTIVITY
FUNCTION

authors:
Choudhary C.
Kumar C.
Gnad F.
Nielsen M.L.
Rehman M.
Walther T.C.
Olsen J.V.
Mann M.

title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

referencePositions: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-382

authors:
Burkard T.R.
Planyavsky M.
Kaupe I.
Breitwieser F.P.
Buerckstuemmer T.
Bennett K.L.
Superti-Furga G.
Colinge J.

title: Initial characterization of the human central proteome.

authors:
Zhou H.
Di Palma S.
Preisinger C.
Peng M.
Polat A.N.
Heck A.J.
Mohammed S.

referencePositions: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242

authors:
Vaca Jacome A.S.
Rabilloud T.
Schaeffer-Reiss C.
Rompais M.
Ayoub D.
Lane L.
Bairoch A.
Van Dorsselaer A.
Carapito C.

title: N-terminome analysis of the human mitochondrial proteome.

authors:
Johnson B.S.
Farkas D.
El-Mergawy R.
Adair J.A.
Elhance A.
Eltobgy M.
Coan F.M.
Chafin L.
Joseph J.A.
Cornwell A.
Johns F.J.
Rosas L.
Rojas M.
Farkas L.
Bednash J.S.
Londino J.D.
Ray P.
Ray A.
Kagan V.
Lee J.S.
Chen B.B.
Mallampalli R.K.

title: Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses.

referencePositions: UBIQUITINATION AT LYS-153; LYS-558 AND LYS-640

referencePositions: MUTAGENESIS OF LYS-153; LYS-368; LYS-558 AND LYS-640

authors:
Neuenfeldt A.
Lorber B.
Ennifar E.
Gaudry A.
Sauter C.
Sissler M.
Florentz C.

title: Thermodynamic properties distinguish human mitochondrial aspartyl-tRNA synthetase from bacterial homolog with same 3D architecture.

referencePositions: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 41-645

authors:
Scheper G.C.
van der Klok T.
van Andel R.J.
van Berkel C.G.M.
Sissler M.
Smet J.
Muravina T.I.
Serkov S.V.
Uziel G.
Bugiani M.
Schiffmann R.
Kraegeloh-Mann I.
Smeitink J.A.M.
Florentz C.
Van Coster R.
Pronk J.C.
van der Knaap M.S.

title: Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation.

authors:
Gonzalez-Serrano L.E.
Karim L.
Pierre F.
Schwenzer H.
Roetig A.
Munnich A.
Sissler M.

title: Three human aminoacyl-tRNA synthetases have distinct sub-mitochondrial localizations that are unaffected by disease-associated mutations.

referencePositions: CHARACTERIZATION OF VARIANTS LBSL GLY-45; LYS-184; LYS-GLN-263; PHE-613; VAL-626 AND GLN-626

referencePositions: MUTAGENESIS OF ARG-58; THR-136 AND GLY-338

authors:
Estevez-Arias B.
Sarv S.
Bonello-Palot N.
Carrera-Garcia L.
Ortez C.
Exposito-Escudero J.
Yubero D.
Muchart J.
Delmont E.
Oiglane-Shlik E.
Meren T.
Puusepp S.
Murumets U.
Salomons G.S.
Udd B.
Vaeli L.
Cantarero L.
Boennemann C.G.
Nascimento A.
Ramon-Maiques S.
Ounap K.
Hoenicka J.
Natera-de Benito D.
Palau F.

title: Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot-Marie-Tooth Disease.

referencePositions: VARIANTS CMT2LL PHE-238; CYS-336 AND LEU-503

referencePositions: CHARACTERIZATION OF VARIANT CMT2LL LEU-503

value: Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome

value: 3 GO annotations based on evolutionary models

value: Expressed in primordial germ cell in gonad and 112 other cell types or tissues


scientificName: Oryza sativa subsp. japonica

commonName: Rice

lineage:
Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
Liliopsida
Poales
Poaceae
BOP clade
Oryzoideae
Oryzeae
Oryzinae
Oryza
Oryza sativa

value: Os08g0135400 protein

description: RING-type

description: Disordered

Proteomics identification

source: PeptideAtlas

source: ProteomicsDB

authoringGroup: International rice genome sequencing project (IRGSP)

authors:
Matsumoto T.
Wu J.
Kanamori H.
Katayose Y.
Fujisawa M.
Namiki N.
Mizuno H.
Yamamoto K.
Antonio B.A.
Baba T.
Sakata K.
Nagamura Y.
Aoki H.
Arikawa K.
Arita K.
Bito T.
Chiden Y.
Fujitsuka N.
Fukunaka R.
Hamada M.
Harada C.
Hayashi A.
Hijishita S.
Honda M.
Hosokawa S.
Ichikawa Y.
Idonuma A.
Iijima M.
Ikeda M.
Ikeno M.
Ito K.
Ito S.
Ito T.
Ito Y.
Ito Y.
Iwabuchi A.
Kamiya K.
Karasawa W.
Kurita K.
Katagiri S.
Kikuta A.
Kobayashi H.
Kobayashi N.
Machita K.
Maehara T.
Masukawa M.
Mizubayashi T.
Mukai Y.
Nagasaki H.
Nagata Y.
Naito S.
Nakashima M.
Nakama Y.
Nakamichi Y.
Nakamura M.
Meguro A.
Negishi M.
Ohta I.
Ohta T.
Okamoto M.
Ono N.
Saji S.
Sakaguchi M.
Sakai K.
Shibata M.
Shimokawa T.
Song J.
Takazaki Y.
Terasawa K.
Tsugane M.
Tsuji K.
Ueda S.
Waki K.
Yamagata H.
Yamamoto M.
Yamamoto S.
Yamane H.
Yoshiki S.
Yoshihara R.
Yukawa K.
Zhong H.
Yano M.
Yuan Q.
Ouyang S.
Liu J.
Jones K.M.
Gansberger K.
Moffat K.
Hill J.
Bera J.
Fadrosh D.
Jin S.
Johri S.
Kim M.
Overton L.
Reardon M.
Tsitrin T.
Vuong H.
Weaver B.
Ciecko A.
Tallon L.
Jackson J.
Pai G.
Aken S.V.
Utterback T.
Reidmuller S.
Feldblyum T.
Hsiao J.
Zismann V.
Iobst S.
de Vazeille A.R.
Buell C.R.
Ying K.
Li Y.
Lu T.
Huang Y.
Zhao Q.
Feng Q.
Zhang L.
Zhu J.
Weng Q.
Mu J.
Lu Y.
Fan D.
Liu Y.
Guan J.
Zhang Y.
Yu S.
Liu X.
Zhang Y.
Hong G.
Han B.
Choisne N.
Demange N.
Orjeda G.
Samain S.
Cattolico L.
Pelletier E.
Couloux A.
Segurens B.
Wincker P.
D'Hont A.
Scarpelli C.
Weissenbach J.
Salanoubat M.
Quetier F.
Yu Y.
Kim H.R.
Rambo T.
Currie J.
Collura K.
Luo M.
Yang T.
Ammiraju J.S.S.
Engler F.
Soderlund C.
Wing R.A.
Palmer L.E.
de la Bastide M.
Spiegel L.
Nascimento L.
Zutavern T.
O'Shaughnessy A.
Dike S.
Dedhia N.
Preston R.
Balija V.
McCombie W.R.
Chow T.
Chen H.
Chung M.
Chen C.
Shaw J.
Wu H.
Hsiao K.
Chao Y.
Chu M.
Cheng C.
Hour A.
Lee P.
Lin S.
Lin Y.
Liou J.
Liu S.
Hsing Y.
Raghuvanshi S.
Mohanty A.
Bharti A.K.
Gaur A.
Gupta V.
Kumar D.
Ravi V.
Vij S.
Kapur A.
Khurana P.
Khurana P.
Khurana J.P.
Tyagi A.K.
Gaikwad K.
Singh A.
Dalal V.
Srivastava S.
Dixit A.
Pal A.K.
Ghazi I.A.
Yadav M.
Pandit A.
Bhargava A.
Sureshbabu K.
Batra K.
Sharma T.R.
Mohapatra T.
Singh N.K.
Messing J.
Nelson A.B.
Fuks G.
Kavchok S.
Keizer G.
Linton E.
Llaca V.
Song R.
Tanyolac B.
Young S.
Ho-Il K.
Hahn J.H.
Sangsakoo G.
Vanavichit A.
de Mattos Luiz.A.T.
Zimmer P.D.
Malone G.
Dellagostin O.
de Oliveira A.C.
Bevan M.
Bancroft I.
Minx P.
Cordum H.
Wilson R.
Cheng Z.
Jin W.
Jiang J.
Leong S.A.
Iwama H.
Gojobori T.
Itoh T.
Niimura Y.
Fujii Y.
Habara T.
Sakai H.
Sato Y.
Wilson G.
Kumar K.
McCouch S.
Juretic N.
Hoen D.
Wright S.
Bruskiewich R.
Bureau T.
Miyao A.
Hirochika H.
Nishikawa T.
Kadowaki K.
Sugiura M.
Burr B.
Sasaki T.

title: The map-based sequence of the rice genome.

value: cv. Nipponbare

type: STRAIN

authors:
Sakai H.
Lee S.S.
Tanaka T.
Numa H.
Kim J.
Kawahara Y.
Wakimoto H.
Yang C.C.
Iwamoto M.
Abe T.
Yamada Y.
Muto A.
Inokuchi H.
Ikemura T.
Matsumoto T.
Sasaki T.
Itoh T.

title: Rice Annotation Project Database (RAP-DB): an integrative and interactive database for rice genomics.

journal: Plant Cell Physiol.

authors:
Kawahara Y.
de la Bastide M.
Hamilton J.P.
Kanamori H.
McCombie W.R.
Ouyang S.
Schwartz D.C.
Tanaka T.
Wu J.
Zhou S.
Childs K.L.
Davidson R.M.
Lin H.
Quesada-Ocampo L.
Vaillancourt B.
Sakai H.
Lee S.S.
Kim J.
Numa H.
Itoh T.
Buell C.R.
Matsumoto T.

title: Improvement of the Oryza sativa Nipponbare reference genome using next generation sequence and optical map data.

journal: Rice

database: EMBL

database: AlphaFoldDB

database: SMR

database: STRING

database: PaxDb

database: Gramene

key: GeneId

database: KEGG

database: eggNOG

key: ToxonomicScope

value: Eukaryota

database: HOGENOM

database: OMA

database: Proteomes

value: Chromosome 8

value: Zinc/RING finger domain, C3HC4 (zinc finger)


source: PubMed

value: Inactive serine protease scarface

value: scaf

value: scarf

value: Inactive serine protease that plays a role in germ-band retraction and dorsal closure morphogenesis in embryogenesis; contributes to amnioserosa attachment and epithelial apico-basal polarity by regulating the localization of laminin LanA on the apical side of the amnioserosa epithelium (PubMed:20379222, PubMed:28628612). Contributes to epithelial morphogenesis probably by regulating the bsk/JNK pathway, as part of a negative-feedback loop, and by modulating the cross-talk between the Egfr, bsk/JNK and dpp signal transduction pathways (PubMed:20379222, PubMed:28628612). In larval development, antagonizes the morphogenetic movements controlled by the bsk/JNK signaling including male genitalia formation and thorax development (PubMed:20379222, PubMed:20530545, PubMed:25737837)

value: Secreted

value: In embryos, expressed in leading edge (LE) cells (at protein level) (PubMed:20530545). In larvae, expressed in the wing imaginal disk cells in the future hinge region, specifically in the peripodial stalk and in the peripodial membrane cells (at protein level) (PubMed:15342518, PubMed:25737837). In larvae, expressed in the A8 abdomen-derived cells in the male genital disk (at protein level) (PubMed:20530545). In third instar larvae, expressed in the anterior and posterios termini (at protein level) (PubMed:15342518). In adult fly, expressed in the wing hinge, in the socket cells of the micro- and macrochaete and proboscis (at protein level) (PubMed:15342518). In embryos, expressed in leading edge (LE) cells during germ-band retraction and dorsal closure from stage 13; expressed in some cells of the amnioserosa in particular in the posterior canthus as well as in the ventral ectoderm; expressed both in head and tail region (PubMed:20379222, PubMed:20530545, PubMed:28628612)

value: The CLIP domain consists of 37-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure

commentType: DOMAIN

value: Embryonic lethal due to defects in the dorsal closure and germ-band retraction; these defects include undifferentiated or defective larval cuticles presenting dorsal holes and wrinkles, defective attachment of the amnioserosa to the tail end of the germ band, defective elongation of the lateral ectoderm with compromised interface between the LE cells and the amnioserosa (PubMed:15342518, PubMed:20379222, PubMed:20530545). RNAi-mediated knockdown results in pupal lethality and scarring (PubMed:25737837). RNAi-mediated knockdown in the epidermis results in loss of wing veins and thorax mechanosensory bristles as well as male terminalia malformations including genitalia rotation defects and partial dissociation of the genital plate from the abdomen (PubMed:20530545). RNAi-mediated knockdown in the dorsal compartment of the wing disk results in loss of bristles from the medio-lateral region of the thorax and in the appearance of a mild thoracic cleft (PubMed:25737837). RNAi-mediated knockdown in the notum area of the wing disk, destined to form the dorsal medio-lateral region of the adult thorax as well as thoracic bristles, results in a thoracic cleft and loss of bristles from the medio-lateral region of the thorax (PubMed:25737837)

commentType: DISRUPTION PHENOTYPE

source: PROSITE-ProRule

value: Belongs to the peptidase S1 family

value: Lacks the conserved residues within the catalytic triad, probably resulting in a loss of proteolytic activity

commentType: CAUTION

description: Inactive serine protease scarface

description: Peptidase S1

description: Disordered

description: CLIP

type: Compositional bias

description: Polar residues

description: Polar residues

source: UniProtKB

authors:
Adams M.D.
Celniker S.E.
Holt R.A.
Evans C.A.
Gocayne J.D.
Amanatides P.G.
Scherer S.E.
Li P.W.
Hoskins R.A.
Galle R.F.
George R.A.
Lewis S.E.
Richards S.
Ashburner M.
Henderson S.N.
Sutton G.G.
Wortman J.R.
Yandell M.D.
Zhang Q.
Chen L.X.
Brandon R.C.
Rogers Y.-H.C.
Blazej R.G.
Champe M.
Pfeiffer B.D.
Wan K.H.
Doyle C.
Baxter E.G.
Helt G.
Nelson C.R.
Miklos G.L.G.
Abril J.F.
Agbayani A.
An H.-J.
Andrews-Pfannkoch C.
Baldwin D.
Ballew R.M.
Basu A.
Baxendale J.
Bayraktaroglu L.
Beasley E.M.
Beeson K.Y.
Benos P.V.
Berman B.P.
Bhandari D.
Bolshakov S.
Borkova D.
Botchan M.R.
Bouck J.
Brokstein P.
Brottier P.
Burtis K.C.
Busam D.A.
Butler H.
Cadieu E.
Center A.
Chandra I.
Cherry J.M.
Cawley S.
Dahlke C.
Davenport L.B.
Davies P.
de Pablos B.
Delcher A.
Deng Z.
Mays A.D.
Dew I.
Dietz S.M.
Dodson K.
Doup L.E.
Downes M.
Dugan-Rocha S.
Dunkov B.C.
Dunn P.
Durbin K.J.
Evangelista C.C.
Ferraz C.
Ferriera S.
Fleischmann W.
Fosler C.
Gabrielian A.E.
Garg N.S.
Gelbart W.M.
Glasser K.
Glodek A.
Gong F.
Gorrell J.H.
Gu Z.
Guan P.
Harris M.
Harris N.L.
Harvey D.A.
Heiman T.J.
Hernandez J.R.
Houck J.
Hostin D.
Houston K.A.
Howland T.J.
Wei M.-H.
Ibegwam C.
Jalali M.
Kalush F.
Karpen G.H.
Ke Z.
Kennison J.A.
Ketchum K.A.
Kimmel B.E.
Kodira C.D.
Kraft C.L.
Kravitz S.
Kulp D.
Lai Z.
Lasko P.
Lei Y.
Levitsky A.A.
Li J.H.
Li Z.
Liang Y.
Lin X.
Liu X.
Mattei B.
McIntosh T.C.
McLeod M.P.
McPherson D.
Merkulov G.
Milshina N.V.
Mobarry C.
Morris J.
Moshrefi A.
Mount S.M.
Moy M.
Murphy B.
Murphy L.
Muzny D.M.
Nelson D.L.
Nelson D.R.
Nelson K.A.
Nixon K.
Nusskern D.R.
Pacleb J.M.
Palazzolo M.
Pittman G.S.
Pan S.
Pollard J.
Puri V.
Reese M.G.
Reinert K.
Remington K.
Saunders R.D.C.
Scheeler F.
Shen H.
Shue B.C.
Siden-Kiamos I.
Simpson M.
Skupski M.P.
Smith T.J.
Spier E.
Spradling A.C.
Stapleton M.
Strong R.
Sun E.
Svirskas R.
Tector C.
Turner R.
Venter E.
Wang A.H.
Wang X.
Wang Z.-Y.
Wassarman D.A.
Weinstock G.M.
Weissenbach J.
Williams S.M.
Woodage T.
Worley K.C.
Wu D.
Yang S.
Yao Q.A.
Ye J.
Yeh R.-F.
Zaveri J.S.
Zhan M.
Zhang G.
Zhao Q.
Zheng L.
Zheng X.H.
Zhong F.N.
Zhong W.
Zhou X.
Zhu S.C.
Zhu X.
Smith H.O.
Gibbs R.A.
Myers E.W.
Rubin G.M.
Venter J.C.

title: The genome sequence of Drosophila melanogaster.

authors:
Misra S.
Crosby M.A.
Mungall C.J.
Matthews B.B.
Campbell K.S.
Hradecky P.
Huang Y.
Kaminker J.S.
Millburn G.H.
Prochnik S.E.
Smith C.D.
Tupy J.L.
Whitfield E.J.
Bayraktaroglu L.
Berman B.P.
Bettencourt B.R.
Celniker S.E.
de Grey A.D.N.J.
Drysdale R.A.
Harris N.L.
Richter J.
Russo S.
Schroeder A.J.
Shu S.Q.
Stapleton M.
Yamada C.
Ashburner M.
Gelbart W.M.
Rubin G.M.
Lewis S.E.

title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

authors:
Stapleton M.
Carlson J.W.
Brokstein P.
Yu C.
Champe M.
George R.A.
Guarin H.
Kronmiller B.
Pacleb J.M.
Park S.
Wan K.H.
Rubin G.M.
Celniker S.E.

title: A Drosophila full-length cDNA resource.

title: A piggyBac transposon gene trap for the analysis of gene expression and function in Drosophila.

authors:
Sorrosal G.
Perez L.
Herranz H.
Milan M.

title: Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo.

referencePositions:
FUNCTION
SUBCELLULAR LOCATION
DEVELOPMENTAL STAGE
DISRUPTION PHENOTYPE

authors:
Rousset R.
Bono-Lauriol S.
Gettings M.
Suzanne M.
Speder P.
Noselli S.

title: The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative-feedback loop during epithelial morphogenesis.

title: Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster.

referencePositions:
FUNCTION
DEVELOPMENTAL STAGE
DISRUPTION PHENOTYPE

authors:
Kushnir T.
Mezuman S.
Bar-Cohen S.
Lange R.
Paroush Z.
Helman A.

title: Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.

value: Expressed in tormogen cell in proboscis and 65 other cell types or tissues

value: P:dorsal closure, elongation of leading edge cells

value: P:establishment or maintenance of epithelial cell apical/basal polarity

value: P:imaginal disc-derived male genitalia morphogenesis