entryType: UniProtKB unreviewed (TrEMBL)

description: FLYWCH-type

source: Pfam

modifier: EXACT

type: Domain

source: EMBL

source: FlyBase

value: RY

Metal-binding

category: Ligand

source: ARBA

Reference proteome

category: Technical term

source: Proteomes

Zinc-finger

category: Domain

commonName: Fruit fly

lineage: Eukaryota Metazoa Ecdysozoa Arthropoda Altocrustacea Allotriocarida Hexapoda Insecta Pterygota Neoptera Eumetabola Endopterygota Aparaglossata Panorpida Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora

scientificName: Drosophila melanogaster

value: Pre-mod(Mdg4)-Y, isoform A

value: Pre-mod(Mdg4)-Y, isoform B

proteinExistence: 4: Predicted

authors:
Adams M.D.
Celniker S.E.
Holt R.A.
Evans C.A.
Gocayne J.D.
Amanatides P.G.
Scherer S.E.
Li P.W.
Hoskins R.A.
Galle R.F.
George R.A.
Lewis S.E.
Richards S.
Ashburner M.
Henderson S.N.
Sutton G.G.
Wortman J.R.
Yandell M.D.
Zhang Q.
Chen L.X.
Brandon R.C.
Rogers Y.H.
Blazej R.G.
Champe M.
Pfeiffer B.D.
Wan K.H.
Doyle C.
Baxter E.G.
Helt G.
Nelson C.R.
Gabor G.L.
Abril J.F.
Agbayani A.
An H.J.
Andrews-Pfannkoch C.
Baldwin D.
Ballew R.M.
Basu A.
Baxendale J.
Bayraktaroglu L.
Beasley E.M.
Beeson K.Y.
Benos P.V.
Berman B.P.
Bhandari D.
Bolshakov S.
Borkova D.
Botchan M.R.
Bouck J.
Brokstein P.
Brottier P.
Burtis K.C.
Busam D.A.
Butler H.
Cadieu E.
Center A.
Chandra I.
Cherry J.M.
Cawley S.
Dahlke C.
Davenport L.B.
Davies P.
de Pablos B.
Delcher A.
Deng Z.
Mays A.D.
Dew I.
Dietz S.M.
Dodson K.
Doup L.E.
Downes M.
Dugan-Rocha S.
Dunkov B.C.
Dunn P.
Durbin K.J.
Evangelista C.C.
Ferraz C.
Ferriera S.
Fleischmann W.
Fosler C.
Gabrielian A.E.
Garg N.S.
Gelbart W.M.
Glasser K.
Glodek A.
Gong F.
Gorrell J.H.
Gu Z.
Guan P.
Harris M.
Harris N.L.
Harvey D.
Heiman T.J.
Hernandez J.R.
Houck J.
Hostin D.
Houston K.A.
Howland T.J.
Wei M.H.
Ibegwam C.
Jalali M.
Kalush F.
Karpen G.H.
Ke Z.
Kennison J.A.
Ketchum K.A.
Kimmel B.E.
Kodira C.D.
Kraft C.
Kravitz S.
Kulp D.
Lai Z.
Lasko P.
Lei Y.
Levitsky A.A.
Li J.
Li Z.
Liang Y.
Lin X.
Liu X.
Mattei B.
McIntosh T.C.
McLeod M.P.
McPherson D.
Merkulov G.
Milshina N.V.
Mobarry C.
Morris J.
Moshrefi A.
Mount S.M.
Moy M.
Murphy B.
Murphy L.
Muzny D.M.
Nelson D.L.
Nelson D.R.
Nelson K.A.
Nixon K.
Nusskern D.R.
Pacleb J.M.
Palazzolo M.
Pittman G.S.
Pan S.
Pollard J.
Puri V.
Reese M.G.
Reinert K.
Remington K.
Saunders R.D.
Scheeler F.
Shen H.
Shue B.C.
Siden-Kiamos I.
Simpson M.
Skupski M.P.
Smith T.
Spier E.
Spradling A.C.
Stapleton M.
Strong R.
Sun E.
Svirskas R.
Tector C.
Turner R.
Venter E.
Wang A.H.
Wang X.
Wang Z.Y.
Wassarman D.A.
Weinstock G.M.
Weissenbach J.
Williams S.M.
WoodageT
Worley K.C.
Wu D.
Yang S.
Yao Q.A.
Ye J.
Yeh R.F.
Zaveri J.S.
Zhan M.
Zhang G.
Zhao Q.
Zheng L.
Zheng X.H.
Zhong F.N.
Zhong W.
Zhou X.
Zhu S.
Zhu X.
Smith H.O.
Gibbs R.A.
Myers E.W.
Rubin G.M.
Venter J.C.

database: PubMed

database: DOI

citationType: journal article

journal: Science

title: The genome sequence of Drosophila melanogaster.

type: STRAIN

value: Berkeley

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

authors:
Celniker S.E.
Wheeler D.A.
Kronmiller B.
Carlson J.W.
Halpern A.
Patel S.
Adams M.
Champe M.
Dugan S.P.
Frise E.
Hodgson A.
George R.A.
Hoskins R.A.
Laverty T.
Muzny D.M.
Nelson C.R.
Pacleb J.M.
Park S.
Pfeiffer B.D.
Richards S.
Sodergren E.J.
Svirskas R.
Tabor P.E.
Wan K.
Stapleton M.
Sutton G.G.
Venter C.
Weinstock G.
Scherer S.E.
Myers E.W.
Gibbs R.A.
Rubin G.M.

journal: Genome Biol.

title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

authors:
Misra S.
Crosby M.A.
Mungall C.J.
Matthews B.B.
Campbell K.S.
Hradecky P.
Huang Y.
Kaminker J.S.
Millburn G.H.
Prochnik S.E.
Smith C.D.
Tupy J.L.
Whitfied E.J.
Bayraktaroglu L.
Berman B.P.
Bettencourt B.R.
Celniker S.E.
de Grey A.D.
Drysdale R.A.
Harris N.L.
Richter J.
Russo S.
Schroeder A.J.
Shu S.Q.
Stapleton M.
Yamada C.
Ashburner M.
Gelbart W.M.
Rubin G.M.
Lewis S.E.

title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

authors:
Kaminker J.S.
Bergman C.M.
Kronmiller B.
Carlson J.
Svirskas R.
Patel S.
Frise E.
Wheeler D.A.
Lewis S.E.
Rubin G.M.
Ashburner M.
Celniker S.E.

title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

authors:
Hoskins R.A.
Smith C.D.
Carlson J.W.
Carvalho A.B.
Halpern A.
Kaminker J.S.
Kennedy C.
Mungall C.J.
Sullivan B.A.
Sutton G.G.
Yasuhara J.C.
Wakimoto B.T.
Myers E.W.
Celniker S.E.
Rubin G.M.
Karpen G.H.

title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

authors:
Quesneville H.
Bergman C.M.
Andrieu O.
Autard D.
Nouaud D.
Ashburner M.
Anxolabehere D.

journal: PLoS Comput. Biol.

title: Combined evidence annotation of transposable elements in genome sequences.

authors:
Celniker S.
Carlson J.
Wan K.
Frise E.
Hoskins R.
Park S.
Svirskas R.
Rubin G.

citationType: submission

submissionDatabase: EMBL/GenBank/DDBJ databases

authors:
Smith C.D.
Shu S.
Mungall C.J.
Karpen G.H.

title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

authors:
Hoskins R.A.
Carlson J.W.
Kennedy C.
Acevedo D.
Evans-Holm M.
Frise E.
Wan K.H.
Park S.
Mendez-Lago M.
Rossi F.
Villasante A.
Dimitri P.
Karpen G.H.
Celniker S.E.

title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

authors:
Matthews B.B.
Dos Santos G.
Crosby M.A.
Emmert D.B.
St Pierre S.E.
Gramates L.S.
Zhou P.
Schroeder A.J.
Falls K.
Strelets V.
Russo S.M.
Gelbart W.M.

title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

authors:
Crosby M.A.
Gramates L.S.
Dos Santos G.
Matthews B.B.
St Pierre S.E.
Zhou P.
Schroeder A.J.
Falls K.
Emmert D.B.
Russo S.M.
Gelbart W.M.

title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

authors:
Hoskins R.A.
Carlson J.W.
Wan K.H.
Park S.
Mendez I.
Galle S.E.
Booth B.W.
Pfeiffer B.D.
George R.A.
Svirskas R.
Krzywinski M.
Schein J.
Accardo M.C.
Damia E.
Messina G.
Mendez-Lago M.
de Pablos B.
Demakova O.V.
Andreyeva E.N.
Boldyreva L.V.
Marra M.
Carvalho A.B.
Dimitri P.
Villasante A.
Zhimulev I.F.
Rubin G.M.
Karpen G.H.
Celniker S.E.

title: The Release 6 reference sequence of the Drosophila melanogaster genome.

authors:
Celniker S.
Carlson J.
Wan K.
Pfeiffer B.
Frise E.
George R.
Hoskins R.
Stapleton M.
Pacleb J.
Park S.
Svirskas R.
Smith E.
Yu C.
Rubin G.

title: Drosophila melanogaster release 4 sequence.

value: Expressed in saliva-secreting gland and 3 other cell types or tissues


description: EF-hand

source: PROSITE

value: EF-hand domain-containing protein

journal: G3 (Bethesda)

value: Expressed in early elongation stage spermatid (Drosophila) in testis and 22 other cell types or tissues

value: EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED


commentType: SIMILARITY

value: Belongs to the peptidase S1 family. CLIP subfamily

commentType: CAUTION

source: PROSITE-ProRule

value: Lacks conserved residue(s) required for the propagation of feature annotation

source: SAM

type: Signal

description: Peptidase S1 domain-containing protein

type: Chain

description: Peptidase S1

type: Disulfide bond

Disulfide bond

category: PTM

value: Peptidase S1 domain-containing protein

proteinExistence: 3: Inferred from homology

value: Expressed in larva and 4 other cell types or tissues


commentType: SUBCELLULAR LOCATION

value: Membrane

value: Peripheral membrane protein

description: Helical

type: Transmembrane

description: LITAF

description: Disordered

type: Region

description: Acidic residues

type: Compositional bias

database: ChEBI

type: Binding site

Membrane

category: Cellular component

value: LITAF domain-containing protein

value: Expressed in larva and 6 other cell types or tissues


value: III

value: LcpIII

value: Larval cuticle protein 3, isoform B

value: Expressed in larva and 5 other cell types or tissues

value: CUTICULAR PROTEIN 65AU, ISOFORM A-RELATED


value: Belongs to the cyclin family

description: Cyclin N-terminal

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Basic residues

description: Low complexity

description: Polar residues

description: Low complexity

description: Polar residues

Cell cycle

category: Biological process

value: Cyclin N-terminal domain-containing protein

value: Berkeley

value: Cyclin E associated events during G1/S transition

value: Cyclin A:Cdk2-associated events at S phase entry

value: Expressed in enterocyte of anterior adult midgut epithelium in digestive tract and 253 other cell types or tissues

value: CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN


commentType: CATALYTIC ACTIVITY

name: Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

value: Belongs to the peptidase S1 family. CLIP subfamily

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Chymotrypsin

description: Peptidase S1

description: Peptidase S1

description: Charge relay system

type: Active site

description: Charge relay system

description: Charge relay system

Hydrolase

category: Molecular function

value: Chymotrypsin

value: Expressed in arthropod fat body and 3 other cell types or tissues


value: Cytoplasm

value: Nucleus

value: Belongs to the peptidase M67A family. CSN5 subfamily

description: MPN

description: JAMM motif

type: Motif

note: catalytic

value: JadBp

value: quo

value: COP9 signalosome complex subunit 5

value: Expressed in cleaving embryo and 105 other cell types or tissues

value: EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED


value: Uncharacterized protein

value: Berkeley


description: Helical

value: Expressed in ovary and 8 other cell types or tissues


source: RuleBase

name: a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP

database: Rhea

name: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

commentType: COFACTOR

value: Belongs to the NDK family

description: Nucleoside diphosphate kinase

description: Nucleoside diphosphate kinase-like

source: SMART

description: Pros-phosphohistidine intermediate

value: awd

value: AWD

value: Awd

value: clone 2.27

value: clone 2.28

value: e(shi)A

value: eshiA

value: K-pn

value: Kpn

value: Expressed in egg cell and 303 other cell types or tissues

value: F:nucleoside diphosphate kinase activity

value: Nucleoside diphosphate kinase-like domain


description: Nucleolar protein 4 helical

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

type: Coiled coil

description: Polar residues

description: Polar residues

description: Low complexity

description: Low complexity

description: Low complexity

description: Low complexity

description: Polar residues

description: Acidic residues

description: Gly residues

value: Nucleolar protein 4 helical domain-containing protein

value: Expressed in T neuron T5a (Drosophila) in embryonic/larval optic lobe (Drosophila) and 100 other cell types or tissues


value: Belongs to the MAGUK family

description: PDZ

description: Guanylate kinase-like

description: Disordered

description: Basic and acidic residues

value: metro

value: met

value: Metro

Proteomics identification

source: PeptideAtlas

value: Menage a trois, isoform A

proteinExistence: 1: Evidence at protein level

value: Berkeley

value: Expressed in cyst progenitor cell (Drosophila) in testis and 137 other cell types or tissues

value: P:regulation of synaptic assembly at neuromuscular junction

value: P-loop containing nucleotide triphosphate hydrolases

value: MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK

value: P-loop containing nucleoside triphosphate hydrolases


source: PIRNR

name: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)

value: Endomembrane system

value: Lipid-anchor

value: Belongs to the phospholipase D family

description: PX

description: PLD phosphodiesterase

description: PLD phosphodiesterase

description: Disordered

description: Disordered

description: Disordered

description: Acidic residues

description: Low complexity

description: Basic and acidic residues

value: Pld

value: dPLD

value: dPld

value: MitoPLD

value: PC-Pld

value: phospholipase D

value: PLD

value: pld

value: Expressed in enterocyte of anterior adult midgut epithelium in digestive tract and 129 other cell types or tissues

value: P:gastrulation involving germ band extension

value: P:phosphatidic acid biosynthetic process

value: P:positive regulation of Golgi vesicle fusion to target membrane

value: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)


commentType: PATHWAY

value: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1

description: SIS

description: SIS

value: GFAT

value: Gfat

value: gfat

value: zep

value: Berkeley

value: F:L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity

value: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

value: Glucose-6-phosphate isomerase like protein, domain 1

value: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

value: N-terminal nucleophile aminohydrolases (Ntn hydrolases)


value: Cell membrane

value: Multi-pass membrane protein

value: Belongs to the G protein-coupled receptor Fz/Smo family

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: FZ

description: G-protein coupled receptors family 2 profile 2

description: Disordered

description: Gly residues

value: Dm Fz2

value: Expressed in T neuron T5d (Drosophila) in embryonic/larval optic lobe (Drosophila) and 296 other cell types or tissues

value: F:transmembrane signaling receptor activity

value: P:cell surface receptor signaling pathway

value: Rhodopsin 7-helix transmembrane proteins


value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Fibrinogen C-terminal domain-containing protein

description: Fibrinogen C-terminal

description: Disordered

value: Assembly of active LPL and LIPC lipase complexes

value: Expressed in hemocyte (sensu Nematoda and Protostomia) in imaginal disc-derived wing and 60 other cell types or tissues

value: P:G protein-coupled receptor signaling pathway


description: Rap-GAP

description: Disordered

description: Disordered

description: Basic residues

description: Low complexity

description: Low complexity

description: Low complexity

value: Rap-GAP domain-containing protein

value: Berkeley

value: Expressed in adult abdominal pericardial cell (Drosophila) in dorsal vessel heart and 198 other cell types or tissues

value: P:regulation of small GTPase mediated signal transduction

value: RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA


description: CID

value: Inr-a

proteinExistence: 2: Evidence at transcript level

authors:
Carlson J.
Booth B.
Frise E.
Sandler J.
Wan K.
Yu C.
Celniker S.

database: EMBL

key: ProteinId

key: Status

key: MoleculeType

value: mRNA

database: RefSeq

key: NucleotideSequenceId

database: AlphaFoldDB

key: Description

database: SMR

database: IntAct

key: Interactions

database: PeptideAtlas

database: DNASU

database: GeneID

database: AGR

database: CTD

database: FlyBase

key: GeneName

database: VEuPathDB

database: HOGENOM

database: OrthoDB

database: BioGRID-ORCS

key: hits

value: 1 hit in 1 CRISPR screen

database: Bgee

key: ExpressionPatterns

value: Expressed in indirect flight muscle cell (Drosophila) in body wall and 279 other cell types or tissues

database: GO

key: GoTerm

value: F:mRNA binding

key: GoEvidenceType

source: PubMed

value: F:RNA binding

value: F:RNA polymerase II complex binding

value: P:mRNA 3'-end processing

value: P:termination of RNA polymerase II transcription

key: EntryName

key: MatchStatus

database: InterPro

database: PANTHER

value: PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11

value: PRE-MRNA CLEAVAGE COMPLEX II

database: SUPFAM

value: ENTH/VHS domain

database: PROSITE

value: CID


value: Protein modification; protein glycosylation

value: Endoplasmic reticulum membrane

value: Single-pass type II membrane protein

value: Belongs to the glycosyltransferase 47 family

description: Glycosyl transferase 64

description: Disordered

description: Polar residues

value: ttv

value: ttv-RA

database: EMBL

database: RefSeq

database: AlphaFoldDB

database: SMR

value: 1 hit in 3 CRISPR screens

value: Expressed in dorsal appendage forming follicle cell in ovary and 276 other cell types or tissues

value: C:endoplasmic reticulum membrane

value: F:glycosyltransferase activity

value: P:glycoprotein biosynthetic process

database: FunFam

value: Tout-velu, isoform B

value: Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A


value: Cytoplasm

value: Nucleus

value: Belongs to the EGR C2H2-type zinc-finger protein family

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Low complexity

description: Low complexity

description: Polar residues

description: Low complexity

description: Low complexity

value: sr

value: Sr

value: SrB

value: Stripe

value: Expressed in hemocyte (sensu Nematoda and Protostomia) in insect leg and 192 other cell types or tissues

value: P:epithelial cell migration, open tracheal system


name: sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

database: Rhea

database: ChEBI

value: Lipid metabolism

value: Phospholipid metabolism; alpha-glycerophosphate cycle

commentType: SUBUNIT

value: Homodimer

value: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

description: Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal

description: Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Polar residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic residues

description: Basic and acidic residues

value: Expressed in early-mid elongation-stage spermatid (Drosophila) in testis and 66 other cell types or tissues

value: F:glycerol-3-phosphate dehydrogenase (NAD+) activity

value: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2

value: 6-phosphogluconate dehydrogenase C-terminal domain-like


value: Cell membrane

value: Multi-pass membrane protein

value: Belongs to the G protein-coupled receptor 1 family

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: G-protein coupled receptors family 1 profile

description: Disordered

description: Polar residues

description: Low complexity

value: DmTRPR

value: DTKR

value: Dtkr

value: dtkr

value: Tak-r

value: TAKR

value: Tk-R 99D

value: Tachykinin-like receptor at 99D, isoform B

value: Expressed in adult abdominal pericardial cell (Drosophila) in dorsal vessel heart and 36 other cell types or tissues

value: Rhodopsin 7-helix transmembrane proteins

value: G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED

value: Family A G protein-coupled receptor-like


source: PIRSR

value: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

description: Biopterin-dependent aromatic amino acid hydroxylase family profile

value: Hn

value: Hn-RB

value: phenylalanine 4-monooxygenase

authors:
Carlson J.
Booth B.
Frise E.
Park S.
Wan K.
Yu C.
Celniker S.

value: Berkeley

value: mRNA

database: PeptideAtlas

database: DNASU

database: GeneID

database: AGR

database: CTD

database: FlyBase

database: VEuPathDB

database: OMA

key: Fingerprint

value: 0 hits in 3 CRISPR screens

value: Expressed in head capsule and 71 other cell types or tissues

value: F:iron ion binding

value: Aromatic amino acid hydroxylase

value: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains


description: Disordered

description: Disordered

description: Basic and acidic residues

description: Low complexity

description: Low complexity

description: Basic and acidic residues

description: Acidic residues

database: KEGG

database: HOGENOM

database: OrthoDB

database: BioGRID-ORCS

value: 0 hits in 1 CRISPR screen

database: Bgee

value: Expressed in posterior terminal follicle cell in ovary and 115 other cell types or tissues

database: CDD

database: InterPro

database: PANTHER

value: RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN CG13096

database: Pfam

database: SUPFAM

value: Ribosomal protein L1


value: Cytoplasm

value: Belongs to the importin beta family. Importin beta-1 subfamily

description: Importin N-terminal

description: HEAT

type: Repeat

value: dKap-beta

value: Hon

value: Imp beta1

value: imp-beta

value: Impbeta

value: impbeta

value: importin beta1

value: Ket

value: Ketel

value: ketel

value: kettle

value: Female sterile (2) ketel, isoform B

value: Female sterile (2) ketel, isoform C

value: Female sterile (2) ketel, isoform D

value: Female sterile (2) ketel, isoform E

database: PubMed

database: DOI

value: Expressed in spermatocyte in testis and 286 other cell types or tissues


description: EFHB C-terminal EF-hand

value: EFHB C-terminal EF-hand domain-containing protein

value: Berkeley

value: Expressed in mid-late elongation-stage spermatid (Drosophila) in testis and 20 other cell types or tissues


value: Nucleus

value: Belongs to the nuclear hormone receptor family. NR5 subfamily

description: Nuclear receptor

description: NR LBD

description: Nuclear receptor

type: DNA binding

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Low complexity

description: Basic residues

description: Low complexity

description: Gly residues

description: Low complexity

description: Gly residues

description: Gly residues

description: Low complexity

description: Gly residues

value: beta FTZ-F1

value: beta Ftz-f1

value: Nuclear receptor subfamily 5 group A member 3

value: Expressed in adult Malpighian tubule stellate cell of main segment in Malpighian tubule and 285 other cell types or tissues

value: Erythroid Transcription Factor GATA-1, subunit A

value: Glucocorticoid receptor-like (DNA-binding domain)


value: Belongs to the cyclin family

description: Cyclin-like

description: Cyclin C-terminal

description: Cyclin-like

description: Disordered

value: CycA

value: Cyc A

value: CYCA

value: cycA

value: CYCLIN A

value: cyclin A

value: CyclinA

value: dCycA

value: DmcycA

value: hari

value: Cyclin A, isoform C

value: Expressed in egg cell and 109 other cell types or tissues


description: Helical

description: Helical

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Polar residues

description: Low complexity

description: Low complexity

description: Low complexity

source: Google

value: Transmembrane protein 268

value: Berkeley

value: Expressed in spermatocyte cyst cell (Drosophila) in testis and 119 other cell types or tissues


commentType: FUNCTION

value: Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development

value: Nucleus

description: BTB

description: HTH psq-type

description: H-T-H motif

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Basic and acidic residues

description: Acidic residues

description: Low complexity

description: Gly residues

description: Gly residues

description: Low complexity

description: Low complexity

description: Basic and acidic residues

description: Low complexity

value: BAB

value: bab

value: bab-II

value: Expressed in adult oenocyte (Drosophila) in body wall and 211 other cell types or tissues

value: F:DNA-binding transcription factor activity

value: F:minor groove of adenine-thymine-rich DNA binding


value: Membrane

value: Multi-pass membrane protein

value: Belongs to the TDE1 family

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Disordered

description: Basic and acidic residues

value: Serinc

value: DmSERINC

value: SERINC

value: Serine incorporator, isoform C

value: Expressed in oviduct (Drosophila) and 257 other cell types or tissues


value: Lacks conserved residue(s) required for the propagation of feature annotation

description: C-type lectin

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Basic residues

description: Polar residues

description: Basic and acidic residues

description: Low complexity

description: Basic and acidic residues

description: Basic and acidic residues

value: rgn

value: RGN

value: Regeneration, isoform B

value: Regeneration, isoform C

value: Berkeley

value: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

value: Retrograde transport at the Trans-Golgi-Network

value: Cargo recognition for clathrin-mediated endocytosis

value: Expressed in peripheral glial cell (Drosophila) in proboscis and 258 other cell types or tissues

value: TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN 2

value: TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN TGN38


value: Nucleus

value: Belongs to the TAF6 family

description: TATA box binding protein associated factor (TAF) histone-like fold

value: TAF

value: TAF[[II]]

value: TFIID

value: TFIID 62

value: Transcription initiation factor TFIID subunit 6

value: Expressed in T neuron T4b (Drosophila) in embryonic/larval optic lobe (Drosophila) and 94 other cell types or tissues

value: F:RNA polymerase II general transcription initiation factor activity

value: P:transcription initiation at RNA polymerase II promoter

value: TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6


value: Belongs to the GDA1/CD39 NTPase family

description: Helical

description: Disordered

description: Low complexity

description: Proton acceptor

value: NTPase

value: dmNTPase

value: nucleoside diphosphate phosphatase

value: Berkeley

value: Expressed in crop (Drosophila) and 218 other cell types or tissues

value: Ectonucleoside triphosphate diphosphohydrolase 5


value: Belongs to the hid-1 family

description: Disordered

description: Acidic residues

description: Polar residues

description: Basic and acidic residues

value: Protein HID1

value: Expressed in cleaving embryo and 51 other cell types or tissues


commentType: INTERACTION

geneName: kirre

geneName: rst

value: Membrane

value: Single-pass type I membrane protein

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Helical

description: Helical

description: Ig-like

description: Ig-like

description: Ig-like

description: Ig-like

description: Ig-like

description: Ig-like

description: Ig-like

description: Ig-like

description: Ig-like

description: Fibronectin type-III

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Low complexity

description: Low complexity

description: Low complexity

description: Low complexity

value: sns

value: Expressed in adult abdominal pericardial cell (Drosophila) in dorsal vessel heart and 94 other cell types or tissues

value: C:protein complex involved in cell adhesion

value: P:compound eye photoreceptor cell differentiation

value: P:regulation of striated muscle tissue development

value: Kirre like nephrin family adhesion molecule 3


value: Belongs to the FMC1 family

value: Protein FMC1 homolog

value: Expressed in adult posterior midgut class II enteroendocrine cell in adult midgut (Drosophila) and 150 other cell types or tissues

value: P:mitochondrial proton-transporting ATP synthase complex assembly


value: Cytoplasm

value: Nucleus, nucleolus

value: Belongs to the RNase PH family

description: Exoribonuclease phosphorolytic

description: Exoribonuclease phosphorolytic

value: Ribosomal RNA-processing protein 42

authors:
Stapleton M.
Carlson J.
Chavez C.
Frise E.
George R.
Pacleb J.
Park S.
Wan K.
Yu C.
Celniker S.

database: EMBL

value: mRNA

database: RefSeq

database: AlphaFoldDB

database: SMR

database: ComplexPortal

value: Nuclear exosome

value: Cytoplasmic exosome

database: IntAct

database: STRING

database: PaxDb

database: PeptideAtlas

database: DNASU

database: GeneID

database: UCSC

key: OrganismName

value: d. melanogaster

database: AGR

database: eggNOG

key: ToxonomicScope

value: Eukaryota

database: Reactome

key: PathwayName

value: mRNA decay by 3' to 5' exoribonuclease

value: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

value: Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

value: Major pathway of rRNA processing in the nucleolus and cytosol

value: Nuclear RNA decay

value: 0 hits in 1 CRISPR screen

value: Expressed in adult enteroendocrine precursor cell in adult midgut (Drosophila) and 38 other cell types or tissues

value: P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

value: P:nuclear polyadenylation-dependent rRNA catabolic process

value: P:TRAMP-dependent tRNA surveillance pathway

value: EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN


geneName: ttk

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: ANK

description: Disordered

description: Disordered

description: Basic residues

description: Low complexity

description: Polar residues

value: Berkeley

key: ProteinId

value: Expressed in multidendritic neuron (Drosophila) in post-embryonic organism and 244 other cell types or tissues

value: P:negative regulation of neuromuscular synaptic transmission

value: P:positive regulation of synaptic assembly at neuromuscular junction

value: ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN


value: Synapse

value: Belongs to the synaptojanin family

value: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family

description: SAC

description: Disordered

description: Pro residues

description: Pro residues

description: Low complexity

description: Polar residues

description: Pro residues

description: Pro residues

value: Synj

value: synaptojanin

value: synj

value: phosphoinositide 5-phosphatase

authors:
Stapleton M.
Carlson J.
Chavez C.
Frise E.
George R.
Pacleb J.
Park S.
Wan K.
Yu C.
Rubin G.M.
Celniker S.

key: Status

value: mRNA

database: GlyGen

key: glycosylation

value: 1 site

database: KEGG

value: Synthesis of PIPs at the plasma membrane

value: Synthesis of IP2, IP, and Ins in the cytosol

value: Expressed in head capsule and 149 other cell types or tissues

value: F:phosphatidylinositol phosphate 5-phosphatase activity

value: P:clathrin-dependent synaptic vesicle endocytosis

value: P:maintenance of presynaptic active zone structure

value: P:negative regulation of smoothened signaling pathway

value: P:positive regulation of autophagosome assembly

value: P:regulation of synapse structure or activity


value: Protein modification; protein ubiquitination

value: Nucleus

value: Belongs to the BACURD family

description: BTB

description: Disordered

description: Polar residues

authors:
Stapleton M.
Brokstein P.
Hong L.
Agbayani A.
Carlson J.
Champe M.
Chavez C.
Dorsett V.
Dresnek D.
Farfan D.
Frise E.
George R.
Gonzalez M.
Guarin H.
Kronmiller B.
Li P.
Liao G.
Miranda A.
Mungall C.J.
Nunoo J.
Pacleb J.
Paragas V.
Park S.
Patel S.
Phouanenavong S.
Wan K.
Yu C.
Lewis S.E.
Rubin G.M.
Celniker S.

value: Berkeley

database: EMBL

key: MoleculeType

key: NucleotideSequenceId

value: d. melanogaster

database: FlyBase

database: VEuPathDB

value: Eukaryota

database: HOGENOM

database: OMA

database: OrthoDB

database: BioGRID-ORCS

value: 0 hits in 3 CRISPR screens

database: Bgee

value: Expressed in cleaving embryo and 204 other cell types or tissues

database: GO

value: F:identical protein binding

value: P:protein homooligomerization

database: CDD

value: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

value: BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER


value: Membrane

value: Multi-pass membrane protein

value: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Potassium channel

description: Potassium channel

description: Disordered

description: Low complexity

value: sand

value: mRNA

database: RefSeq

database: AlphaFoldDB

key: Description

database: STRING

database: PaxDb

database: DNASU

database: GeneID

value: TWIK-related spinal cord K+ channel (TRESK)

value: Expressed in adult class III enteroendocrine cell in adult midgut (Drosophila) and 35 other cell types or tissues

value: P:negative regulation of circadian sleep/wake cycle, sleep

value: P:negative regulation of membrane potential


name: a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)

database: Rhea

database: ChEBI

name: a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

name: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)

value: Endoplasmic reticulum

value: Vacuole membrane

value: Belongs to the VMP1 family

description: Helical

description: Helical

description: Helical

description: Helical

description: KMS1 N-terminal

description: Vacuole membrane protein 1 C-terminal helical

description: Disordered

description: Disordered

description: Polar residues

description: Basic and acidic residues

description: Polar residues

description: Basic residues

authors:
Adams M.D.
Celniker S.E.
Holt R.A.
Evans C.A.
Gocayne J.D.
Amanatides P.G.
Scherer S.E.
Li P.W.
Hoskins R.A.
Galle R.F.
George R.A.
Lewis S.E.
Richards S.
Ashburner M.
Henderson S.N.
Sutton G.G.
Wortman J.R.
Yandell M.D.
Zhang Q.
Chen L.X.
Brandon R.C.
Rogers Y.H.
Blazej R.G.
Champe M.
Pfeiffer B.D.
Wan K.H.
Doyle C.
Baxter E.G.
Helt G.
Nelson C.R.
Gabor G.L.
Abril J.F.
Agbayani A.
An H.J.
Andrews-Pfannkoch C.
Baldwin D.
Ballew R.M.
Basu A.
Baxendale J.
Bayraktaroglu L.
Beasley E.M.
Beeson K.Y.
Benos P.V.
Berman B.P.
Bhandari D.
Bolshakov S.
Borkova D.
Botchan M.R.
Bouck J.
Brokstein P.
Brottier P.
Burtis K.C.
Busam D.A.
Butler H.
Cadieu E.
Center A.
Chandra I.
Cherry J.M.
Cawley S.
Dahlke C.
Davenport L.B.
Davies P.
de Pablos B.
Delcher A.
Deng Z.
Mays A.D.
Dew I.
Dietz S.M.
Dodson K.
Doup L.E.
Downes M.
Dugan-Rocha S.
Dunkov B.C.
Dunn P.
Durbin K.J.
Evangelista C.C.
Ferraz C.
Ferriera S.
Fleischmann W.
Fosler C.
Gabrielian A.E.
Garg N.S.
Gelbart W.M.
Glasser K.
Glodek A.
Gong F.
Gorrell J.H.
Gu Z.
Guan P.
Harris M.
Harris N.L.
Harvey D.
Heiman T.J.
Hernandez J.R.
Houck J.
Hostin D.
Houston K.A.
Howland T.J.
Wei M.H.
Ibegwam C.
Jalali M.
Kalush F.
Karpen G.H.
Ke Z.
Kennison J.A.
Ketchum K.A.
Kimmel B.E.
Kodira C.D.
Kraft C.
Kravitz S.
Kulp D.
Lai Z.
Lasko P.
Lei Y.
Levitsky A.A.
Li J.
Li Z.
Liang Y.
Lin X.
Liu X.
Mattei B.
McIntosh T.C.
McLeod M.P.
McPherson D.
Merkulov G.
Milshina N.V.
Mobarry C.
Morris J.
Moshrefi A.
Mount S.M.
Moy M.
Murphy B.
Murphy L.
Muzny D.M.
Nelson D.L.
Nelson D.R.
Nelson K.A.
Nixon K.
Nusskern D.R.
Pacleb J.M.
Palazzolo M.
Pittman G.S.
Pan S.
Pollard J.
Puri V.
Reese M.G.
Reinert K.
Remington K.
Saunders R.D.
Scheeler F.
Shen H.
Shue B.C.
Siden-Kiamos I.
Simpson M.
Skupski M.P.
Smith T.
Spier E.
Spradling A.C.
Stapleton M.
Strong R.
Sun E.
Svirskas R.
Tector C.
Turner R.
Venter E.
Wang A.H.
Wang X.
Wang Z.Y.
Wassarman D.A.
Weinstock G.M.
Weissenbach J.
Williams S.M.
WoodageT
Worley K.C.
Wu D.
Yang S.
Yao Q.A.
Ye J.
Yeh R.F.
Zaveri J.S.
Zhan M.
Zhang G.
Zhao Q.
Zheng L.
Zheng X.H.
Zhong F.N.
Zhong W.
Zhou X.
Zhu S.
Zhu X.
Smith H.O.
Gibbs R.A.
Myers E.W.
Rubin G.M.
Venter J.C.

authors:
Celniker S.E.
Wheeler D.A.
Kronmiller B.
Carlson J.W.
Halpern A.
Patel S.
Adams M.
Champe M.
Dugan S.P.
Frise E.
Hodgson A.
George R.A.
Hoskins R.A.
Laverty T.
Muzny D.M.
Nelson C.R.
Pacleb J.M.
Park S.
Pfeiffer B.D.
Richards S.
Sodergren E.J.
Svirskas R.
Tabor P.E.
Wan K.
Stapleton M.
Sutton G.G.
Venter C.
Weinstock G.
Scherer S.E.
Myers E.W.
Gibbs R.A.
Rubin G.M.

value: Expressed in posterior terminal follicle cell in ovary and 257 other cell types or tissues


description: CHK kinase-like

value: CHK kinase-like domain-containing protein

database: PubMed

database: DOI

value: Berkeley

authors:
Misra S.
Crosby M.A.
Mungall C.J.
Matthews B.B.
Campbell K.S.
Hradecky P.
Huang Y.
Kaminker J.S.
Millburn G.H.
Prochnik S.E.
Smith C.D.
Tupy J.L.
Whitfied E.J.
Bayraktaroglu L.
Berman B.P.
Bettencourt B.R.
Celniker S.E.
de Grey A.D.
Drysdale R.A.
Harris N.L.
Richter J.
Russo S.
Schroeder A.J.
Shu S.Q.
Stapleton M.
Yamada C.
Ashburner M.
Gelbart W.M.
Rubin G.M.
Lewis S.E.

authors:
Kaminker J.S.
Bergman C.M.
Kronmiller B.
Carlson J.
Svirskas R.
Patel S.
Frise E.
Wheeler D.A.
Lewis S.E.
Rubin G.M.
Ashburner M.
Celniker S.E.

value: Expressed in early-mid elongation-stage spermatid (Drosophila) in testis and 22 other cell types or tissues


value: Cytoplasm

value: Belongs to the RRM CPEB family

description: RRM

description: Disordered

description: Low complexity

value: orb

value: ORB

value: Orb

value: Oo18 RNA-binding protein, isoform C

value: Oo18 RNA-binding protein, isoform E

authors:
Hoskins R.A.
Smith C.D.
Carlson J.W.
Carvalho A.B.
Halpern A.
Kaminker J.S.
Kennedy C.
Mungall C.J.
Sullivan B.A.
Sutton G.G.
Yasuhara J.C.
Wakimoto B.T.
Myers E.W.
Celniker S.E.
Rubin G.M.
Karpen G.H.

authors:
Quesneville H.
Bergman C.M.
Andrieu O.
Autard D.
Nouaud D.
Ashburner M.
Anxolabehere D.

value: Expressed in mid-late elongation-stage spermatid (Drosophila) in testis and 144 other cell types or tissues

value: P:dorsal/ventral axis specification, ovarian follicular epithelium

value: P:oocyte anterior/posterior axis specification

value: P:oocyte dorsal/ventral axis specification

value: Putative Cytoplasmic polyadenylation element-binding protein 1

value: Cytoplasmic polyadenylation element-binding protein, ZZ domain

value: CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB

value: CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1


description: RRM

description: Disordered

description: Low complexity

value: glo

value: Glo

value: Glorund, isoform C

value: Berkeley

authors:
Smith C.D.
Shu S.
Mungall C.J.
Karpen G.H.

value: Expressed in T neuron T5b (Drosophila) in embryonic/larval optic lobe (Drosophila) and 288 other cell types or tissues

value: P:intracellular mRNA localization involved in pattern specification process

value: P:maternal specification of dorsal/ventral axis, oocyte, germ-line encoded


value: Belongs to the peptidase S1 family. CLIP subfamily

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Peptidase S1 domain-containing protein

description: Peptidase S1

value: Peptidase S1 domain-containing protein

authors:
Hoskins R.A.
Carlson J.W.
Kennedy C.
Acevedo D.
Evans-Holm M.
Frise E.
Wan K.H.
Park S.
Mendez-Lago M.
Rossi F.
Villasante A.
Dimitri P.
Karpen G.H.
Celniker S.E.

value: Expressed in arthropod fat body and 3 other cell types or tissues

value: P:positive regulation of hemocyte proliferation


value: Uncharacterized protein

authors:
Matthews B.B.
Dos Santos G.
Crosby M.A.
Emmert D.B.
St Pierre S.E.
Gramates L.S.
Zhou P.
Schroeder A.J.
Falls K.
Strelets V.
Russo S.M.
Gelbart W.M.

value: Expressed in fat body cell in dorsal vessel heart and 12 other cell types or tissues


description: Calponin-homology (CH)

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Polar residues

value: Male specific transcript 27D, isoform A

value: Male specific transcript 27D, isoform B

authors:
Celniker S.
Carlson J.
Wan K.
Frise E.
Hoskins R.
Park S.
Svirskas R.
Rubin G.

authors:
Crosby M.A.
Gramates L.S.
Dos Santos G.
Matthews B.B.
St Pierre S.E.
Zhou P.
Schroeder A.J.
Falls K.
Emmert D.B.
Russo S.M.
Gelbart W.M.

value: Expressed in early elongation stage spermatid (Drosophila) in testis and 37 other cell types or tissues

value: P:regulation of microtubule polymerization or depolymerization

value: MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER


description: Chymotrypsin

description: Peptidase S1

description: Charge relay system

description: Charge relay system

description: Charge relay system

value: Chymotrypsin

authors:
Hoskins R.A.
Carlson J.W.
Wan K.H.
Park S.
Mendez I.
Galle S.E.
Booth B.W.
Pfeiffer B.D.
George R.A.
Svirskas R.
Krzywinski M.
Schein J.
Accardo M.C.
Damia E.
Messina G.
Mendez-Lago M.
de Pablos B.
Demakova O.V.
Andreyeva E.N.
Boldyreva L.V.
Marra M.
Carvalho A.B.
Dimitri P.
Villasante A.
Zhimulev I.F.
Rubin G.M.
Karpen G.H.
Celniker S.E.


value: Nucleus, nucleolus

value: Belongs to the ESF2/ABP1 family

description: RRM

description: Disordered

description: Basic and acidic residues

value: RRM domain-containing protein

value: Berkeley

value: Expressed in spermatocyte in testis and 56 other cell types or tissues

value: P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

value: P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

value: P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)


value: Belongs to the peptidase S1 family. CLIP subfamily

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Chymotrypsin

description: Peptidase S1

description: Charge relay system

description: Charge relay system

description: Charge relay system

value: Expressed in fat body cell in dorsal vessel heart and 11 other cell types or tissues


value: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

value: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells

value: Cytoplasm, cytoskeleton

value: Belongs to the tubulin family

description: Tubulin/FtsZ GTPase

description: Tubulin/FtsZ 2-layer sandwich

description: Disordered

description: Acidic residues

value: Tubulin beta chain

database: EMBL

value: mRNA

database: SMR

database: IntAct

key: Interactions

database: PeptideAtlas

database: KEGG

database: AGR

database: CTD

database: FlyBase

key: GeneName

database: VEuPathDB

database: HOGENOM

value: HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

value: COPI-independent Golgi-to-ER retrograde traffic

value: Expressed in capitellum (Drosophila) and 106 other cell types or tissues

value: F:structural constituent of cytoskeleton


description: Helical

database: RefSeq

database: AlphaFoldDB

database: STRING

database: PaxDb

database: UCSC

value: d. melanogaster

database: eggNOG

value: Eukaryota

database: OMA

database: BioGRID-ORCS

key: hits

value: 0 hits in 1 CRISPR screen

database: Bgee

key: ExpressionPatterns

value: Expressed in mid-late elongation-stage spermatid (Drosophila) in testis and 21 other cell types or tissues


value: Belongs to the NDRG family

description: Disordered

description: Disordered

authors:
Stapleton M.
Brokstein P.
Hong L.
Agbayani A.
Carlson J.
Champe M.
Chavez C.
Dorsett V.
Farfan D.
Frise E.
George R.
Gonzalez M.
Guarin H.
Li P.
Liao G.
Miranda A.
Mungall C.J.
Nunoo J.
Pacleb J.
Paragas V.
Park S.
Phouanenavong S.
Wan K.
Yu C.
Lewis S.E.
Rubin G.M.
Celniker S.

value: Berkeley

database: EMBL

database: SMR

database: IntAct

database: ESTHER

key: FamilyName

database: DNASU

database: GeneID

database: OrthoDB

value: 0 hits in 3 CRISPR screens

value: Expressed in adult Malpighian tubule tiny cell (Drosophila) in Malpighian tubule and 290 other cell types or tissues

database: FunFam

value: protein NDRG3 isoform X8

value: alpha/beta hydrolase

database: InterPro

value: NDRG

database: PANTHER

value: N-MYC DOWNSTREAM REGULATED

database: Pfam


value: Fibp

value: AFGF intracellular binding protein

authors:
Kolpakova E.
Frengen E.
Stokke T.
Olsnes S.

database: PubMed

database: DOI

journal: Biochem. J.

title: Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein.

authors:
Kolpakova E.N.
Olsnes S.

value: mRNA

database: RefSeq

database: AlphaFoldDB

database: PeptideAtlas

database: KEGG

database: AGR

database: CTD

database: FlyBase

database: VEuPathDB

value: Expressed in adult abdominal pericardial cell (Drosophila) in dorsal vessel heart and 153 other cell types or tissues

key: EntryName

value: FIBP

value: ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN

value: ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN


geneName: spn-F

value: Cytoplasm

description: Protein kinase

database: ChEBI

value: IKKepsilon

value: dIKK

value: dIKKepsilon

value: DmIKKepsilon

value: IKK

value: ikkepsilon

value: I-kappaB kinase epsilon, isoform B

value: I-kappaB kinase epsilon, isoform C

authors:
Celniker S.
Carlson J.
Wan K.
Pfeiffer B.
Frise E.
George R.
Hoskins R.
Stapleton M.
Pacleb J.
Park S.
Svirskas R.
Smith E.
Yu C.
Rubin G.

value: Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

value: Expressed in second segment of antenna (Drosophila) and 70 other cell types or tissues

value: F:protein serine/threonine kinase activity

value: P:maintenance of epithelial integrity, open tracheal system

value: P:oocyte anterior/posterior axis specification

value: P:positive regulation of apoptotic process

value: P:positive regulation of signal transduction

value: P:positive regulation of type I interferon production

value: P:regulation of cytoskeleton organization

value: inhibitor of nuclear factor kappa-B kinase subunit epsilon

value: serine/threonine-protein kinase TBK1 isoform X1

value: Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1


value: Nucleus

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Polar residues

description: Polar residues

description: Polar residues

description: Low complexity

description: Polar residues

description: Low complexity

description: Low complexity

description: Low complexity

description: Basic residues

description: Basic residues

value: Expressed in alpha'/beta' Kenyon cell (Drosophila) in insect head and 98 other cell types or tissues

value: P:positive regulation of female receptivity

value: GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED


value: Cell membrane

value: Single-pass type II membrane protein

value: Belongs to the peptidase M13 family

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Peptidase M13 N-terminal

description: Peptidase M13 C-terminal

value: Neprilysin-like 19

value: Berkeley

value: Expressed in embryonic/larval hemocyte (Drosophila) and 16 other cell types or tissues

value: ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED

value: Metalloproteases ('zincins'), catalytic domain


value: Belongs to the enoyl-CoA hydratase/isomerase family

description: Enoyl-CoA hydratase/isomerase-like

value: Enoyl-CoA hydratase/isomerase-like domain-containing protein

value: Expressed in dorsal cluster neuron (Drosophila) in brain and 49 other cell types or tissues

value: 2-enoyl-CoA Hydratase, Chain A, domain 1


H2O2 + AH2 = A + 2 H2O

database: Rhea

value: Binds 1 Ca(2+) ion per heterodimer.

value: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.

value: Secreted

value: Belongs to the peroxidase family

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Low complexity

description: Acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Polar residues

description: Low complexity

description: Polar residues

description: Proton acceptor

description: covalent

description: covalent

description: axial binding residue

description: Transition state stabilizer

value: Expressed in esophagus (Drosophila) and 18 other cell types or tissues

value: P:cellular process involved in reproduction in multicellular organism

value: Haem peroxidase domain superfamily, animal type


description: Disordered

description: Disordered

description: Gly residues

description: Low complexity

description: Low complexity

value: Genetic suppressor element-like domain-containing protein

value: Expressed in T neuron T5b (Drosophila) in embryonic/larval optic lobe (Drosophila) and 50 other cell types or tissues


value: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6

value: Nucleus

value: Belongs to the importin beta family

description: Importin N-terminal

value: cdm

value: Cdm

source: PDB

value: Berkeley

authors:
Bono F.
Cook A.G.
Grunwald M.
Ebert J.
Conti E.

title: Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13.

title: Structural basis for the nuclear export activity of Importin13.

value: Expressed in oviduct (Drosophila) and 80 other cell types or tissues

value: C:NLS-dependent protein nuclear import complex

value: P:modulation of chemical synaptic transmission

value: P:positive regulation of protein-containing complex disassembly


directionType: left-to-right

name: coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H(+)

name: coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)

name: coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)

name: heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)

name: pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)

name: protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)

name: uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H(+)

name: uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H(+)

value: Homodimer

value: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: ABC transmembrane type-1

description: ABC transporter

description: Disordered

description: Gly residues

description: Basic residues

authors:
Adams M.D.
Celniker S.E.
Holt R.A.
Evans C.A.
Gocayne J.D.
Amanatides P.G.
Scherer S.E.
Li P.W.
Hoskins R.A.
Galle R.F.
George R.A.
Lewis S.E.
Richards S.
Ashburner M.
Henderson S.N.
Sutton G.G.
Wortman J.R.
Yandell M.D.
Zhang Q.
Chen L.X.
Brandon R.C.
Rogers Y.H.
Blazej R.G.
Champe M.
Pfeiffer B.D.
Wan K.H.
Doyle C.
Baxter E.G.
Helt G.
Nelson C.R.
Gabor G.L.
Abril J.F.
Agbayani A.
An H.J.
Andrews-Pfannkoch C.
Baldwin D.
Ballew R.M.
Basu A.
Baxendale J.
Bayraktaroglu L.
Beasley E.M.
Beeson K.Y.
Benos P.V.
Berman B.P.
Bhandari D.
Bolshakov S.
Borkova D.
Botchan M.R.
Bouck J.
Brokstein P.
Brottier P.
Burtis K.C.
Busam D.A.
Butler H.
Cadieu E.
Center A.
Chandra I.
Cherry J.M.
Cawley S.
Dahlke C.
Davenport L.B.
Davies P.
de Pablos B.
Delcher A.
Deng Z.
Mays A.D.
Dew I.
Dietz S.M.
Dodson K.
Doup L.E.
Downes M.
Dugan-Rocha S.
Dunkov B.C.
Dunn P.
Durbin K.J.
Evangelista C.C.
Ferraz C.
Ferriera S.
Fleischmann W.
Fosler C.
Gabrielian A.E.
Garg N.S.
Gelbart W.M.
Glasser K.
Glodek A.
Gong F.
Gorrell J.H.
Gu Z.
Guan P.
Harris M.
Harris N.L.
Harvey D.
Heiman T.J.
Hernandez J.R.
Houck J.
Hostin D.
Houston K.A.
Howland T.J.
Wei M.H.
Ibegwam C.
Jalali M.
Kalush F.
Karpen G.H.
Ke Z.
Kennison J.A.
Ketchum K.A.
Kimmel B.E.
Kodira C.D.
Kraft C.
Kravitz S.
Kulp D.
Lai Z.
Lasko P.
Lei Y.
Levitsky A.A.
Li J.
Li Z.
Liang Y.
Lin X.
Liu X.
Mattei B.
McIntosh T.C.
McLeod M.P.
McPherson D.
Merkulov G.
Milshina N.V.
Mobarry C.
Morris J.
Moshrefi A.
Mount S.M.
Moy M.
Murphy B.
Murphy L.
Muzny D.M.
Nelson D.L.
Nelson D.R.
Nelson K.A.
Nixon K.
Nusskern D.R.
Pacleb J.M.
Palazzolo M.
Pittman G.S.
Pan S.
Pollard J.
Puri V.
Reese M.G.
Reinert K.
Remington K.
Saunders R.D.
Scheeler F.
Shen H.
Shue B.C.
Siden-Kiamos I.
Simpson M.
Skupski M.P.
Smith T.
Spier E.
Spradling A.C.
Stapleton M.
Strong R.
Sun E.
Svirskas R.
Tector C.
Turner R.
Venter E.
Wang A.H.
Wang X.
Wang Z.Y.
Wassarman D.A.
Weinstock G.M.
Weissenbach J.
Williams S.M.
WoodageT
Worley K.C.
Wu D.
Yang S.
Yao Q.A.
Ye J.
Yeh R.F.
Zaveri J.S.
Zhan M.
Zhang G.
Zhao Q.
Zheng L.
Zheng X.H.
Zhong F.N.
Zhong W.
Zhou X.
Zhu S.
Zhu X.
Smith H.O.
Gibbs R.A.
Myers E.W.
Rubin G.M.
Venter J.C.

value: Expressed in adult Malpighian tubule (Drosophila) and 147 other cell types or tissues

value: P:cellular detoxification of cadmium ion

value: ATP-binding cassette sub-family B member 6, mitochondrial

value: ATP-binding cassette sub-family B member 7, mitochondrial

value: ABC transporter type 1, transmembrane domain

value: P-loop containing nucleotide triphosphate hydrolases

value: ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6

value: P-loop containing nucleoside triphosphate hydrolases


description: Helical

description: VWFC

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Low complexity

description: Polar residues

description: Low complexity

description: Low complexity

description: Polar residues

description: Polar residues

description: Low complexity

description: Low complexity

description: Low complexity

description: Polar residues

description: Polar residues

description: Basic and acidic residues

description: Polar residues

authors:
Celniker S.E.
Wheeler D.A.
Kronmiller B.
Carlson J.W.
Halpern A.
Patel S.
Adams M.
Champe M.
Dugan S.P.
Frise E.
Hodgson A.
George R.A.
Hoskins R.A.
Laverty T.
Muzny D.M.
Nelson C.R.
Pacleb J.M.
Park S.
Pfeiffer B.D.
Richards S.
Sodergren E.J.
Svirskas R.
Tabor P.E.
Wan K.
Stapleton M.
Sutton G.G.
Venter C.
Weinstock G.
Scherer S.E.
Myers E.W.
Gibbs R.A.
Rubin G.M.

value: Expressed in gamma Kenyon cell (Drosophila) in insect head and 124 other cell types or tissues


value: Belongs to the peptidase S1 family. CLIP subfamily

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Chymotrypsin

description: Peptidase S1

description: Charge relay system

description: Charge relay system

description: Charge relay system

value: Chymotrypsin

authors:
Misra S.
Crosby M.A.
Mungall C.J.
Matthews B.B.
Campbell K.S.
Hradecky P.
Huang Y.
Kaminker J.S.
Millburn G.H.
Prochnik S.E.
Smith C.D.
Tupy J.L.
Whitfied E.J.
Bayraktaroglu L.
Berman B.P.
Bettencourt B.R.
Celniker S.E.
de Grey A.D.
Drysdale R.A.
Harris N.L.
Richter J.
Russo S.
Schroeder A.J.
Shu S.Q.
Stapleton M.
Yamada C.
Ashburner M.
Gelbart W.M.
Rubin G.M.
Lewis S.E.


description: NADP-dependent oxidoreductase

value: NADP-dependent oxidoreductase domain-containing protein

value: Berkeley

authors:
Kaminker J.S.
Bergman C.M.
Kronmiller B.
Carlson J.
Svirskas R.
Patel S.
Frise E.
Wheeler D.A.
Lewis S.E.
Rubin G.M.
Ashburner M.
Celniker S.E.

value: Expressed in adult anterior midgut class II enteroendocrine cell in adult midgut (Drosophila) and 54 other cell types or tissues


description: CHK kinase-like

description: CHK kinase-like

description: Disordered

description: Basic and acidic residues

value: CHK kinase-like domain-containing protein

authors:
Hoskins R.A.
Smith C.D.
Carlson J.W.
Carvalho A.B.
Halpern A.
Kaminker J.S.
Kennedy C.
Mungall C.J.
Sullivan B.A.
Sutton G.G.
Yasuhara J.C.
Wakimoto B.T.
Myers E.W.
Celniker S.E.
Rubin G.M.
Karpen G.H.

value: Expressed in midgut large flat cell (Drosophila) in digestive tract and 52 other cell types or tissues


value: Endoplasmic reticulum

description: TPR

description: TPR

description: TPR

description: TPR

description: TPR

description: J

description: Disordered

value: dIPK

authors:
Quesneville H.
Bergman C.M.
Andrieu O.
Autard D.
Nouaud D.
Ashburner M.
Anxolabehere D.

value: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

value: Expressed in embryonic/larval hemocyte (Drosophila) and 156 other cell types or tissues

value: P:protein folding in endoplasmic reticulum


value: Membrane

value: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

value: Ethanolaminephosphotransferase 1

authors:
Smith C.D.
Shu S.
Mungall C.J.
Karpen G.H.

value: Expressed in adult differentiating enterocyte in digestive tract and 108 other cell types or tissues


description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Disordered

description: Disordered

description: Disordered

description: Gly residues

description: Low complexity

description: Gly residues

value: hbt

value: Headbutt, isoform D

authors:
Hoskins R.A.
Carlson J.W.
Kennedy C.
Acevedo D.
Evans-Holm M.
Frise E.
Wan K.H.
Park S.
Mendez-Lago M.
Rossi F.
Villasante A.
Dimitri P.
Karpen G.H.
Celniker S.E.

value: Expressed in outer photoreceptor cell (Drosophila) in insect head and 142 other cell types or tissues


value: Multi-pass membrane protein

description: Helical

description: Helical

description: Helical

description: Helical

value: Tetraspanin 33B

authors:
Matthews B.B.
Dos Santos G.
Crosby M.A.
Emmert D.B.
St Pierre S.E.
Gramates L.S.
Zhou P.
Schroeder A.J.
Falls K.
Strelets V.
Russo S.M.
Gelbart W.M.

value: Expressed in early-mid elongation-stage spermatid (Drosophila) in testis and 19 other cell types or tissues


value: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. In addition, it catalyzes the formation of pseudouridine mainly at positions 31 and 32 in the anticodon loop of cytosolic and mitochondrial tRNAs, and at position 34 of certain cytosolic tRNAs such as tRNA(Ile)

name: a uridine in mRNA = a pseudouridine in mRNA

name: a uridine in tRNA = a pseudouridine in tRNA

name: uridine(31) in tRNA = pseudouridine(31) in tRNA

name: uridine(32) in tRNA = pseudouridine(32) in tRNA

value: Belongs to the pseudouridine synthase RluA family

description: Pseudouridine synthase RsuA/RluA-like

description: Disordered

description: Disordered

description: Low complexity

description: Polar residues

value: RNA pseudouridylate synthase domain-containing protein 2

value: Pseudouridylate synthase RPUSD2

value: Berkeley

authors:
Celniker S.
Carlson J.
Wan K.
Frise E.
Hoskins R.
Park S.
Svirskas R.
Rubin G.

value: Expressed in transmedullary neuron Tm1 (Drosophila) in insect head and 81 other cell types or tissues

value: P:enzyme-directed rRNA pseudouridine synthesis

value: RNA pseudouridine synthase domain-containing 2

value: MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE


value: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

name: 2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)

name: cytidine + H2O + H(+) = uridine + NH4(+)

value: Belongs to the cytidine and deoxycytidylate deaminase family

description: CMP/dCMP-type deaminase

description: Proton donor

value: Cytidine aminohydrolase

value: Cytidine deaminase

authors:
Crosby M.A.
Gramates L.S.
Dos Santos G.
Matthews B.B.
St Pierre S.E.
Zhou P.
Schroeder A.J.
Falls K.
Emmert D.B.
Russo S.M.
Gelbart W.M.

value: Expressed in seminal fluid secreting gland and 86 other cell types or tissues


description: Helical

description: Helical

description: Disordered

description: Disordered

description: Low complexity

value: Uncharacterized protein

authors:
Hoskins R.A.
Carlson J.W.
Wan K.H.
Park S.
Mendez I.
Galle S.E.
Booth B.W.
Pfeiffer B.D.
George R.A.
Svirskas R.
Krzywinski M.
Schein J.
Accardo M.C.
Damia E.
Messina G.
Mendez-Lago M.
de Pablos B.
Demakova O.V.
Andreyeva E.N.
Boldyreva L.V.
Marra M.
Carvalho A.B.
Dimitri P.
Villasante A.
Zhimulev I.F.
Rubin G.M.
Karpen G.H.
Celniker S.E.

value: Expressed in adult posterior midgut class II enteroendocrine cell in adult midgut (Drosophila) and 19 other cell types or tissues


value: Expressed in early-mid elongation-stage spermatid (Drosophila) in testis and 22 other cell types or tissues

value: Haloacid dehalogenase-like hydrolase family protein


value: Membrane

value: Multi-pass membrane protein

value: Belongs to the major facilitator superfamily. MFSD6 family

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Low complexity

description: Basic and acidic residues

description: Polar residues

description: Polar residues

value: Major facilitator superfamily associated domain-containing protein

value: Expressed in cortex associated CNS glial cell (Drosophila) in post-embryonic organism and 57 other cell types or tissues

value: MFS general substrate transporter like domains

value: MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE


name: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

name: Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

value: Secreted, extracellular space

value: Belongs to the peptidase S1 family

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Chymotrypsin

description: Peptidase S1

description: Charge relay system

description: Charge relay system

description: Charge relay system

value: Chymotrypsin

value: Berkeley

value: Expressed in spermathecum and 9 other cell types or tissues


value: Nucleus

value: Belongs to the WD repeat SWD2 family

description: WD

value: WD repeat-containing protein 82

value: Expressed in spermatocyte in testis and 14 other cell types or tissues

value: YVTN repeat-like/Quinoprotein amine dehydrogenase


value: Cytoplasm

value: Belongs to the importin beta family

description: Importin N-terminal

description: Disordered

description: Disordered

description: Acidic residues

description: Acidic residues

value: msk

value: Imp 7

value: Msk

value: Moleskin

value: Transcriptional regulation by small RNAs

value: Expressed in cleaving embryo and 210 other cell types or tissues

value: F:nuclear import signal receptor activity

value: P:compound eye cone cell differentiation

value: P:imaginal disc-derived wing morphogenesis

value: P:imaginal disc-derived wing vein morphogenesis

value: P:imaginal disc-derived wing vein specification

value: P:negative regulation of neuron apoptotic process


value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Helical

description: Kazal-like

description: Kazal-like

description: Kazal-like

description: Kazal-like

description: Kazal-like

description: Kazal-like

description: Kazal-like

description: Disordered

description: Polar residues

description: Reactive bond

type: Site

description: Reactive bond

description: Reactive bond

description: Reactive bond

description: Reactive bond

description: Reactive bond

description: Reactive bond

value: Expressed in peripheral glial cell (Drosophila) in insect leg and 115 other cell types or tissues

value: Serine protease inhibitor dipetalogastin


name: tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)

value: Cytoplasm

value: Nucleus

value: Belongs to the class-I aminoacyl-tRNA synthetase family

description: TRNA-binding

value: TyrRS

value: Aats-tyr

value: dTyrRS

value: dYARS

value: EMAP

value: YARS

value: YRS

value: Tyrosyl-tRNA synthetase

value: Tyrosine--tRNA ligase

value: Berkeley

value: Expressed in oviduct (Drosophila) and 149 other cell types or tissues

value: tyrosine--tRNA ligase, cytoplasmic isoform X2

value: TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER


value: Membrane

value: Multi-pass membrane protein

value: Belongs to the mitochondrial carrier (TC 2.A.29) family

description: Helical

description: Helical

description: Solcar

description: Solcar

description: Solcar

value: Dicarboxylate carrier 4, isoform A

value: Dicarboxylate carrier 4, isoform C

value: Expressed in early-mid elongation-stage spermatid (Drosophila) in testis and 17 other cell types or tissues

value: F:sulfate transmembrane transporter activity

value: F:thiosulfate transmembrane transporter activity


description: Helicase ATP-binding

description: Helicase C-terminal

description: Disordered

description: Basic residues

description: Basic and acidic residues

value: RNA helicase

value: Expressed in cleaving embryo and 29 other cell types or tissues

value: P-loop containing nucleotide triphosphate hydrolases

value: P-loop containing nucleoside triphosphate hydrolases


description: Pupal cuticle protein Edg-91

value: Pupal cuticle protein Edg-91

value: Expressed in larva and 2 other cell types or tissues


description: K Homology

description: Disordered

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Basic and acidic residues

description: Low complexity

description: Basic and acidic residues

value: Quaking related 58E-1, isoform A

value: Berkeley

value: PTK6 Regulates Proteins Involved in RNA Processing

value: Expressed in distal medullary amacrine neuron Dm9 in insect head and 266 other cell types or tissues

value: P:regulation of alternative mRNA splicing, via spliceosome

value: Eukaryotic type KH-domain (KH-domain type I)


description: F-box

description: Disordered

description: Disordered

description: Gly residues

description: Low complexity

description: Low complexity

description: Pro residues

value: F-box protein 42

value: Expressed in medullary tangential neuron Mt1 (Drosophila) in brain and 64 other cell types or tissues

value: F:ubiquitin-like ligase-substrate adaptor activity

value: P:positive regulation of synaptonemal complex assembly

value: P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process


description: Helical

description: Helical

description: Helical

description: Helical

description: Farnesoic acid O-methyl transferase

value: NtR

value: DNtR

value: NTR

value: NtR, isoform A

value: Expressed in embryonic/larval hemocyte (Drosophila) and 58 other cell types or tissues

value: F:extracellular ligand-gated monoatomic ion channel activity

value: P:monoatomic ion transmembrane transport

value: Neurotransmitter-gated ion-channel ligand-binding domain

value: Multidrug efflux transporter AcrB transmembrane domain

value: Nicotinic receptor ligand binding domain-like


value: Nucleus

description: Fork-head

description: Fork-head

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Polar residues

description: Low complexity

description: Acidic residues

value: jumu

value: Dmjumu

value: Dom

value: Dwhn

value: Jumeau

value: jumeaux

value: Jumu

value: jumu/Dom

value: Whn

value: Berkeley

value: Expressed in wing disc and 65 other cell types or tissues

value: F:cis-regulatory region sequence-specific DNA binding

value: F:DNA-binding transcription factor activity

value: F:transcription cis-regulatory region binding

value: P:imaginal disc-derived wing morphogenesis

value: P:positive regulation of receptor signaling pathway via JAK-STAT

value: P:regulation of DNA-templated transcription

value: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain


value: Belongs to the RHPN family

description: PDZ

description: Disordered

description: Low complexity

value: Rhp

value: Rhophilin

authors:
Edwards K.A.
Kaneshiro K.
Yamamoto D.

title: Mutations in the Drosophila Rhophilin gene at 13E.

authors:
Stapleton M.
Carlson J.
Chavez C.
Frise E.
George R.
Pacleb J.
Park S.
Wan K.
Yu C.
Rubin G.M.
Celniker S.

database: EMBL

value: mRNA

database: SMR

database: IntAct

database: STRING

database: PaxDb

database: DNASU

database: GeneID

database: UCSC

value: d. melanogaster

database: eggNOG

value: Eukaryota

database: HOGENOM

value: RHO GTPases Activate Rhotekin and Rhophilins

value: Expressed in adult Malpighian tubule bar-shaped cell of initial segment in Malpighian tubule and 72 other cell types or tissues

value: P:negative regulation of stress fiber assembly


value: Cytoplasm

description: DRBM

description: DRBM

description: DRBM

description: Disordered

description: Polar residues

description: Gly residues

value: loqs

value: dRax

value: loq

value: LOQS

value: Loqs

value: Loqs-PD

value: LqPD

value: TRBP

value: Loquacious, isoform F

database: PubMed

database: DOI

value: Berkeley

authors:
Tants J.N.
Fesser S.
Kern T.
Stehle R.
Geerlof A.
Wunderlich C.
Juen M.
Hartlmuller C.
Bottcher R.
Kunzelmann S.
Lange O.
Kreutz C.
Forstemann K.
Sattler M.

title: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.

value: Expressed in mid-late elongation-stage spermatid (Drosophila) in testis and 171 other cell types or tissues

value: P:dosage compensation by hyperactivation of X chromosome

value: P:female germ-line stem cell asymmetric division

value: P:germ-line stem cell population maintenance

value: P:regulation of regulatory ncRNA processing

value: Double-stranded RNA-binding protein Staufen homolog 1


description: Glycosyl-hydrolase family 116 N-terminal

description: Glycosyl-hydrolase family 116 catalytic region

value: Uncharacterized protein

title: The genome sequence of Drosophila melanogaster.

value: Expressed in adult Malpighian tubule principal cell of lower segment in Malpighian tubule and 142 other cell types or tissues

value: F:hydrolase activity, hydrolyzing O-glycosyl compounds


value: Belongs to the peptidase S1 family. CLIP subfamily

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Peptidase S1 domain-containing protein

description: Peptidase S1

value: Peptidase S1 domain-containing protein

title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

value: Expressed in adult Malpighian tubule principal cell of initial segment in Malpighian tubule and 18 other cell types or tissues