entryType: UniProtKB unreviewed (TrEMBL)

scientificName: Equus caballus

commonName: Horse

source: Ensembl

source: Proteomes

lineage: Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Perissodactyla Equidae Equus

proteinExistence: 1: Evidence at protein level

source: ARBA

value: Vesicle-associated membrane protein-associated protein A

source: VGNC

value: VAPA

value: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking

commentType: FUNCTION

commentType: SUBCELLULAR LOCATION

value: Cell junction, tight junction

value: Cell membrane

value: Single-pass type IV membrane protein

value: Endoplasmic reticulum membrane

value: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family

commentType: SIMILARITY

type: Transmembrane

modifier: EXACT

description: Helical

source: SAM

type: Domain

description: MSP

source: PROSITE

type: Region

description: Disordered

type: Coiled coil

type: Compositional bias

description: Basic and acidic residues

Acetylation

category: PTM

Cell junction

category: Cellular component

Coiled coil

category: Domain

Proteomics identification

source: PeptideAtlas

category: Technical term

citationType: journal article

authoringGroup: Broad Institute Genome Sequencing Platform

authoringGroup: Broad Institute Whole Genome Assembly Team

authors:
Wade C.M.
Giulotto E.
Sigurdsson S.
Zoli M.
Gnerre S.
Imsland F.
Lear T.L.
Adelson D.L.
Bailey E.
Bellone R.R.
Bloecker H.
Distl O.
Edgar R.C.
Garber M.
Leeb T.
Mauceli E.
MacLeod J.N.
Penedo M.C.T.
Raison J.M.
Sharpe T.
Vogel J.
Andersson L.
Antczak D.F.
Biagi T.
Binns M.M.
Chowdhary B.P.
Coleman S.J.
Della Valle G.
Fryc S.
Guerin G.
Hasegawa T.
Hill E.W.
Jurka J.
Kiialainen A.
Lindgren G.
Liu J.
Magnani E.
Mickelson J.R.
Murray J.
Nergadze S.G.
Onofrio R.
Pedroni S.
Piras M.F.
Raudsepp T.
Rocchi M.
Roeed K.H.
Ryder O.A.
Searle S.
Skow L.
Swinburne J.E.
Syvaenen A.C.
Tozaki T.
Valberg S.J.
Vaudin M.
White J.R.
Zody M.C.
Lander E.S.
Lindblad-Toh K.

database: PubMed

database: DOI

title: Genome sequence, comparative analysis, and population genetics of the domestic horse.

journal: Science

referencePositions: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

value: Thoroughbred

type: STRAIN

citationType: submission

submissionDatabase: UniProtKB

database: RefSeq

key: NucleotideSequenceId

database: AlphaFoldDB

key: Description

database: Ensembl

key: ProteinId

key: GeneId

database: GeneID

database: KEGG

value: Expressed in muscle tissue and 23 other cell types or tissues

value: vesicle-associated membrane protein-associated protein A isoform X1

value: VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A


proteinExistence: 4: Predicted

value: Calcyphosine like

value: CAPSL

description: EF-hand

description: EF-hand

description: EF-hand

Calcium

source: PROSITE-ProRule

category: Ligand

database: FunCoup

key: Number of interactors

database: STRING

database: PaxDb

database: VGNC

key: GeneName

database: GeneTree

database: InParanoid

database: Proteomes

key: Component

value: Chromosome 21

database: Bgee

key: ExpressionPatterns

value: Expressed in epithelium of bronchus and 5 other cell types or tissues

database: GO

key: GoTerm

value: F:calcium ion binding

key: GoEvidenceType

key: EntryName

value: EF-hand

key: MatchStatus

database: InterPro

value: Ca-bind

database: PANTHER

value: CALCYPHOSIN

value: CALCYPHOSIN-LIKE PROTEIN

database: Pfam

database: PRINTS


value: Myosin light chain 10

description: EF-hand

description: EF-hand

description: Disordered

description: Basic residues

description: Basic and acidic residues

Motor protein

category: Molecular function

database: PubMed

database: DOI

database: RefSeq

database: AlphaFoldDB

database: CTD

value: Chromosome 13

database: FunFam

value: Myosin regulatory light chain 2, atrial isoform

value: Putative myosin regulatory light chain sqh


value: Krev interaction trapped protein 1

value: Cell junction

value: Cell membrane

value: Peripheral membrane protein

value: Cytoplasm, cytoskeleton

type: Repeat

description: ANK

description: FERM

Angiogenesis

category: Biological process

value: Thoroughbred

database: Ensembl

value: Chromosome 4

database: ExpressionAtlas

value: baseline

value: C:anchoring junction

value: C:plasma membrane

value: P:negative regulation of developmental process

value: P:regulation of multicellular organismal development

database: CDD

value: krev interaction trapped protein 1 isoform X1

value: KRIT, N-terminal Nudix domain, NPxY motif-rich region

value: Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1

value: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)


value: CTD small phosphatase 2

description: Disordered

description: Low complexity

database: FunCoup

database: STRING

database: PaxDb

database: VGNC

database: GeneTree

database: HOGENOM

database: InParanoid

value: Chromosome 6

value: Expressed in synovial membrane of synovial joint and 23 other cell types or tissues


value: Astrocytic phosphoprotein PEA-15

value: 15 kDa phosphoprotein enriched in astrocytes

value: Cytoplasm

description: DED

database: GeneID

database: Proteomes

value: Chromosome 5

database: GO

value: P:MAPK cascade

value: P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

value: astrocytic phosphoprotein PEA-15 isoform X1

value: Death Domain, Fas

database: InterPro

database: PANTHER

value: ASTROCYTIC PHOSPHOPROTEIN PEA-15

value: DED DOMAIN-CONTAINING PROTEIN

database: Pfam


value: Aldehyde dehydrogenase family 7 member A1

value: Betaine aldehyde dehydrogenase

commentType: CATALYTIC ACTIVITY

name: (E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2-enoate + NADH + 2 H(+)

database: Rhea

database: ChEBI

directionType: left-to-right

name: (E)-non-2-enal + NAD(+) + H2O = (E)-non-2-enoate + NADH + 2 H(+)

name: (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)

name: an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)

name: betaine aldehyde + NAD(+) + H2O = glycine betaine + NADH + 2 H(+)

name: hexanal + NAD(+) + H2O = hexanoate + NADH + 2 H(+)

name: malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+)

name: nonanal + NAD(+) + H2O = nonanoate + NADH + 2 H(+)

name: octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+)

value: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1

value: Belongs to the aldehyde dehydrogenase family

description: Aldehyde dehydrogenase

value: F:betaine-aldehyde dehydrogenase (NAD+) activity

value: F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity

value: Aldehyde Dehydrogenase, Chain A, domain 1

value: Aldehyde Dehydrogenase, Chain A, domain 2


proteinExistence: 3: Inferred from homology

value: Growth hormone secretagogue receptor type 1

value: GH-releasing peptide receptor

value: Ghrelin receptor

value: GHSR

value: Interacts with the heterotrimeric G protein complex composed of 3 units, alpha, beta and gamma; this complex may consist of GNB1 and GNG2

commentType: SUBUNIT

value: Cell membrane

value: Multi-pass membrane protein

source: RuleBase

value: Belongs to the G protein-coupled receptor 1 family

value: Lacks conserved residue(s) required for the propagation of feature annotation

commentType: CAUTION

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: G-protein coupled receptors family 1 profile

database: PubMed

database: DOI

value: Thoroughbred

database: RefSeq

value: Expressed in inner cell mass and 5 other cell types or tissues

value: F:growth hormone secretagogue receptor activity

value: F:growth hormone-releasing hormone receptor activity

value: P:actin polymerization or depolymerization

value: P:G protein-coupled receptor signaling pathway

value: P:negative regulation of inflammatory response

value: P:negative regulation of interleukin-1 beta production

value: P:negative regulation of interleukin-6 production

value: P:negative regulation of tumor necrosis factor production

value: P:positive regulation of multicellular organism growth

value: growth hormone secretagogue receptor type 1

value: Rhodopsin 7-helix transmembrane proteins

value: GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1

value: Family A G protein-coupled receptor-like


value: Asparagine-linked glycosylation protein 5 homolog

name: a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP

value: Protein modification; protein glycosylation

commentType: PATHWAY

value: Endoplasmic reticulum membrane

value: Single-pass membrane protein

value: Belongs to the glycosyltransferase 2 family

description: Glycosyltransferase 2-like

source: Pfam

database: AlphaFoldDB

database: Ensembl

value: Chromosome 17

database: Bgee

value: Expressed in trophoblast and 23 other cell types or tissues

database: ExpressionAtlas

value: baseline

value: C:endoplasmic reticulum membrane

database: CDD

database: FunFam

value: Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A


value: 60 kDa heat shock protein, mitochondrial

value: 60 kDa chaperonin

value: Chaperonin 60

value: Heat shock protein 60

value: Mitochondrial matrix protein P1

value: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein

name: ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.

value: Homoheptamer arranged in a ring structure. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. Interacts with 2 heptameric Hsp10 rings to form the symmetrical football complex. Interacts with HRAS. Interacts with ATAD3A. Interacts with ETFBKMT and EEF1AKMT3. Interacts with MFHAS1

value: Mitochondrion matrix

value: Belongs to the TCP-1 chaperonin family

value: Belongs to the chaperonin (HSP60) family

value: Thoroughbred

database: FunCoup

database: STRING

database: PaxDb

database: VGNC

database: GeneTree

database: HOGENOM

database: InParanoid

value: Chromosome 18

value: Expressed in trophectoderm and 23 other cell types or tissues

value: C:chaperonin-containing T-complex

value: C:mitochondrial matrix

value: F:ATP binding

value: F:ATP-dependent protein folding chaperone

value: P:positive regulation of cytokine production

value: Chaperonin 60 subunit alpha 2 chloroplastic

value: 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL


value: C-X-C chemokine receptor type 3

value: Interferon-inducible protein 10 receptor

value: Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. Probably promotes cell chemotaxis response. Receptor for chemokine CCL21. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling

value: Homomer. Forms heteromers with ACKR4. Interacts with PF4/CXCL4

value: Cell membrane

value: Multi-pass membrane protein

value: Belongs to the G protein-coupled receptor 1 family

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Disordered

description: Polar residues

type: Disulfide bond

value: Rhodopsin 7-helix transmembrane proteins

value: Family A G protein-coupled receptor-like


value: Aspartyl-tRNA synthetase 2, mitochondrial

value: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily

description: Aminoacyl-transfer RNA synthetases class-II family profile

value: Thoroughbred

database: Proteomes

value: Chromosome 5

value: baseline

database: GO

value: F:aminoacyl-tRNA ligase activity

value: F:nucleic acid binding

value: P:tRNA aminoacylation for protein translation

value: Aspartate--tRNA ligase, mitochondrial

value: Bira Bifunctional Protein, Domain 2

value: GAD-like domain

value: Nucleic acid-binding proteins

database: HAMAP

database: InterPro


source: PIRNR

value: Glycerol-3-phosphate acyltransferase 1, mitochondrial

value: GPAM

value: Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids. Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid. Has a narrow hydrophobic binding cleft that selects for a linear acyl chain. Catalytic activity is higher for substrates with a 16-carbon acyl chain

name: (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA

database: Rhea

database: ChEBI

name: 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

name: dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA

name: sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

name: sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

name: sn-glycerol 3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA

name: sn-glycerol 3-phosphate + octadecanoyl-CoA = 1-octadecanoyl-sn-glycero-3-phosphate + CoA

value: Lipid metabolism

value: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3

value: Mitochondrion outer membrane

value: Peripheral membrane protein

value: Belongs to the GPAT/DAPAT family

description: Phospholipid/glycerol acyltransferase

source: SMART

description: Disordered

value: GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL


value: Heat shock 70 kDa protein 4

value: Interacts with TJP1/ZO-1

value: Cytoplasm

value: Belongs to the heat shock protein 70 family

description: HYOU1-like C-terminal

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

database: PubMed

database: DOI

value: Thoroughbred

database: AlphaFoldDB

database: Ensembl

value: Chromosome 14

value: baseline

value: F:ATP binding

value: F:ATP hydrolysis activity

value: Heat shock protein 70 (HSP70)-4, putative

value: Substrate Binding Domain Of DNAk, Chain A, domain 1

value: Heat shock protein 70kD (HSP70), C-terminal subdomain

value: Heat shock protein 70kD (HSP70), peptide-binding domain


value: Dual oxidase 1

value: Cell membrane

value: Membrane

value: Multi-pass membrane protein

value: Belongs to the peroxidase family

value: Lacks conserved residue(s) required for the propagation of feature annotation

type: Signal

type: Chain

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: FAD-binding FR-type

value: Haem peroxidase domain superfamily, animal type

value: Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module

value: Ferredoxin reductase-like, C-terminal NADP-linked domain


value: Myotubularin-related protein 9

value: Inactive phosphatidylinositol 3-phosphatase 9

value: Cell projection, ruffle membrane

value: Peripheral membrane protein

value: Cytoplasmic side

value: Cytoplasm, perinuclear region

value: Endoplasmic reticulum

value: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily

description: Myotubularin phosphatase

value: Thoroughbred

value: Chromosome 2

database: ExpressionAtlas

value: C:endoplasmic reticulum

value: C:perinuclear region of cytoplasm

value: C:ruffle membrane

database: CDD

database: FunFam

value: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

value: (Phosphotyrosine protein) phosphatases II


value: Protein-tyrosine-phosphatase

name: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

value: Cytoplasmic vesicle, secretory vesicle membrane

value: Single-pass type I membrane protein

value: Synapse

description: Protein-tyrosine-phosphatase

description: Helical

description: Tyrosine-protein phosphatase

description: Tyrosine specific protein phosphatases

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Polar residues

description: Low complexity

type: Active site

description: Phosphocysteine intermediate

value: receptor-type tyrosine-protein phosphatase-like N isoform X2

value: Protein tyrosine phosphatase superfamily

value: Protein-tyrosine phosphatase receptor IA-2 ectodomain

value: IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C

value: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2


value: DNA methyltransferase 3 like

value: Nucleus

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: PHD-type

database: OrthoDB

value: Chromosome 26

value: C:condensed nuclear chromosome

value: C:ESC/E(Z) complex

value: F:enzyme activator activity

value: F:enzyme binding

value: P:genomic imprinting

value: P:male meiosis I

value: P:negative regulation of DNA methylation-dependent heterochromatin formation

value: P:negative regulation of DNA-templated transcription

value: P:stem cell differentiation

value: P:transposable element silencing by piRNA-mediated DNA methylation

value: Zinc/RING finger domain, C3HC4 (zinc finger)

value: DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED


value: Interleukin 1 receptor associated kinase 3

value: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily

description: Protein kinase

description: Disordered

description: Disordered

value: Thoroughbred

database: VGNC

database: GeneTree

value: Chromosome 6

database: Bgee

value: Expressed in liver and 21 other cell types or tissues

value: F:ATP binding

value: F:protein kinase activity

value: P:signal transduction

value: Death Domain, Fas

value: Phosphorylase Kinase, domain 1

database: PANTHER

value: INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3

database: Pfam

value: Death


value: Serine/threonine-protein phosphatase 4 regulatory subunit 4

value: Putative regulatory subunit of serine/threonine-protein phosphatase 4

value: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R4

value: Cytoplasm

description: HEAT

description: HEAT

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Polar residues

database: Proteomes

value: Chromosome 24

value: baseline

database: GO

value: Leucine-rich Repeat Variant

value: ARM-like

value: PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4

value: SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4


value: Serine/threonine-protein

name: L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)

database: Rhea

name: L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)

name: [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)

value: Component of the CDK-activating kinase (CAK) complex, consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity. CAK binds to both free CDK2 and cyclin-bound CDK2, with a higher affinity for the cyclin-bound form. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI. Interacts with HINT1

value: Nucleus

value: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily

value: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family

description: Protein kinase

description: Proton acceptor

source: PIRSR

type: Binding site

value: C:transcription factor TFIIH core complex

value: F:cyclin-dependent protein serine/threonine kinase activity

value: F:RNA polymerase II CTD heptapeptide repeat S5 kinase activity

value: P:positive regulation of transcription by RNA polymerase II

value: P:regulation of G1/S transition of mitotic cell cycle

value: P:transcription initiation at RNA polymerase II promoter


database: ChEBI

name: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)

value: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily

description: Protein kinase

description: Disordered

description: Proton acceptor

value: P:regulation of early endosome to late endosome transport

value: P:regulation of stress-activated MAPK cascade

value: Dual specificity mitogen-activated protein kinase kinase 1

value: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN

value: MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2


value: Palmitoyltransferase

name: L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA

value: Golgi apparatus membrane

value: Multi-pass membrane protein

value: The DHHC domain is required for palmitoyltransferase activity

commentType: DOMAIN

value: Belongs to the DHHC palmitoyltransferase family

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Helical

description: Palmitoyltransferase DHHC

description: Disordered

description: S-palmitoyl cysteine intermediate

database: PubMed

value: Thoroughbred

value: P:protein localization to plasma membrane

value: ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN


value: Cholesterol 25-hydroxylase

value: Membrane

description: Helical

description: Helical

description: Helical

description: Helical

description: Fatty acid hydroxylase

database: DOI

database: RefSeq

database: STRING

database: PaxDb

database: GeneID

database: KEGG

database: CTD

database: HOGENOM

database: InParanoid

database: OMA

key: Fingerprint

database: BRENDA

key: OrganismId

value: Chromosome 1

value: Expressed in synovial membrane of synovial joint and 17 other cell types or tissues

value: P:cholesterol biosynthetic process via desmosterol

value: P:negative regulation of cholesterol metabolic process

value: P:negative regulation of fusion of virus membrane with host plasma membrane


value: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes. Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning. May also function as a transporter of branched chain alpha-keto acids

name: L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

name: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

name: L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate

commentType: COFACTOR

value: Homodimer

value: Mitochondrion

value: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family

description: Disordered

description: Gly residues

description: Low complexity

database: AlphaFoldDB

database: Ensembl

value: P:branched-chain amino acid catabolic process

value: D-amino Acid Aminotransferase, subunit A, domain 2

value: D-aminoacid aminotransferase-like PLP-dependent enzymes


value: Sirtuin 5

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Deacetylase sirtuin-type

value: Thoroughbred

database: FunCoup

database: VGNC

database: GeneTree

database: Proteomes

value: Chromosome 20

database: Bgee

value: Expressed in muscle tissue and 23 other cell types or tissues

database: ExpressionAtlas

value: baseline

database: GO

value: F:NAD+ binding

value: TPP-binding domain

database: InterPro

value: Sirtuin

database: PANTHER

value: NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED

database: Pfam

database: SUPFAM

value: DHS-like NAD/FAD-binding domain

database: PROSITE

value: SIRTUIN


value: Ubiquitin carboxyl-terminal hydrolase

name: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

value: Forms a ternary complex with RNF128 and OTUB1. Interacts (via C-terminal UCH catalytic domain) with OTUB1 isoform 1. Interacts with STAM2 (via SH3 domain). Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ. Interacts with NBR1, RASGRF1, RNF41 and IST1. Associates with the ESCRT-0 complex and with microtubules. Interacts with BIRC6/bruce and KIF23/MKLP1

value: Cell membrane

value: Peripheral membrane protein

value: Cytoplasm

value: Endosome membrane

value: Nucleus

value: Belongs to the peptidase C19 family

description: Rhodanese

description: USP

description: Disordered

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic and acidic residues

description: Polar residues

description: Nucleophile

description: Proton acceptor

value: Putative ubiquitin carboxyl-terminal hydrolase 8

value: Phosphotransferase system, lactose/cellobiose-type IIA subunit

value: Rhodanese/Cell cycle control phosphatase


value: Overlapping with the m-AAA protease 1 homolog

database: ChEBI

value: Homooligomer

value: Mitochondrion inner membrane

value: Single-pass membrane protein

value: Belongs to the peptidase M48 family

description: Helical

description: Peptidase M48

database: PubMed

database: DOI

value: Thoroughbred

value: Chromosome 2

value: baseline

value: C:mitochondrial inner membrane

value: P:negative regulation of mitochondrial fusion

value: P:positive regulation of apoptotic process

value: P:protein quality control for misfolded or incompletely synthesized proteins

value: metalloendopeptidase OMA1, mitochondrial isoform X1

value: Metalloproteases ('zincins'), catalytic domain


value: Protein EFR3 homolog A

value: Protein EFR3-like

value: Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2)

value: Cell membrane

value: Lipid-anchor

value: Belongs to the EFR3 family

description: EFR3-like ARM-repeat

database: AlphaFoldDB

value: Chromosome 9

value: C:plasma membrane

database: FunFam

value: EFR3 homolog A (S. cerevisiae)

value: Leucine-rich Repeat Variant

value: ARM-like

value: PROTEIN EFR3 HOMOLOG A

value: PROTEIN EFR3 HOMOLOG CMP44E

value: ARM repeat


value: Voltage-dependent L-type calcium channel subunit beta-3

value: Calcium channel voltage-dependent subunit beta 3

value: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation

value: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio. Interacts with CACNA2D4. Interacts with FASLG. Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel

value: Cytoplasm

value: Belongs to the calcium channel beta subunit family

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Polar residues

description: Basic and acidic residues

value: Thoroughbred

database: Ensembl

value: Chromosome 6

value: Expressed in prefrontal cortex and 22 other cell types or tissues

value: C:L-type voltage-gated calcium channel complex

value: F:high voltage-gated calcium channel activity

value: Voltage-dependent L-type calcium channel subunit beta-2

value: P-loop containing nucleotide triphosphate hydrolases

value: VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT

value: P-loop containing nucleoside triphosphate hydrolases


value: Shieldin complex subunit 2

description: Shieldin complex subunit 2 first OB fold

description: Shieldin complex subunit 2 second OB fold

description: Shieldin complex subunit 2 C-terminal

description: Disordered

description: Basic and acidic residues

value: Chromosome 1

value: SHIELDIN COMPLEX SUBUNIT 2


value: Gem-associated protein 5

value: Nucleus, gem

value: Nucleus, nucleoplasm

value: Belongs to the WD repeat gemin-5 family

description: WD

description: Gem-associated protein 5 first beta-propeller

description: WD

description: Gem-associated protein 5 second beta-propeller

description: WD

description: Gem-associated protein 5 TPR

description: Gem-associated protein 5 RBS

description: Disordered

description: Disordered

description: Polar residues

description: Polar residues

value: YVTN repeat-like/Quinoprotein amine dehydrogenase


value: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation

value: Interacts with SRC. Interacts with LCK when tyrosine phosphorylated

value: Cytoplasm

description: PH

description: PH

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Acidic residues

description: Low complexity

description: Basic and acidic residues

description: Low complexity

value: Thoroughbred

value: Actin filament-associated protein 1-like 2 isoform 1

value: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

value: ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER

value: ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2


value: Olfactomedin like 2A

value: Secreted

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: Olfactomedin-like

description: Disordered

description: Disordered

description: Low complexity

description: Basic and acidic residues

description: Basic and acidic residues

description: Low complexity

value: Chromosome 25

value: C:extracellular region

value: OLFACTOMEDIN-LIKE PROTEIN 2A

value: OLFACTOMEDIN-RELATED

value: OLF

database: SMART


value: Coiled-coil and C2 domain containing 2A

description: Disordered

description: Disordered

description: Disordered

description: Basic and acidic residues

description: Basic and acidic residues

description: Basic residues

description: Acidic residues

description: Polar residues

database: VGNC

database: GeneTree

value: Chromosome 3

value: Expressed in oviduct epithelium and 21 other cell types or tissues

value: baseline

value: C2 domain

value: COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A


value: WD repeat containing planar cell polarity effector

value: WDPCP

value: Cell membrane

value: Cytoplasm, cytoskeleton, cilium axoneme

value: Belongs to the WD repeat fritz family

value: Thoroughbred

database: FunCoup

database: STRING

database: PaxDb

database: InParanoid

database: Proteomes

value: Chromosome 15

database: Bgee

value: Expressed in oviduct epithelium and 22 other cell types or tissues

value: C:plasma membrane

value: Frtz

value: WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG


value: TNF receptor-associated factor

name: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

value: Protein modification; protein ubiquitination

value: Cytoplasm

value: Belongs to the TNF receptor-associated factor family. A subfamily

description: RING-type

description: TRAF-type

description: TRAF-type

description: MATH

type: Zinc finger

description: TRAF-type

description: TRAF-type

value: Expressed in leukocyte and 22 other cell types or tissues

value: F:tumor necrosis factor receptor binding

value: P:positive regulation of canonical NF-kappaB signal transduction

value: P:positive regulation of gene expression

value: P:regulation of production of molecular mediator of immune response

value: P:tumor necrosis factor-mediated signaling pathway

value: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A

value: Zinc/RING finger domain, C3HC4 (zinc finger)


value: Wee1-like protein kinase

value: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation

database: Rhea

value: Binds 2 magnesium ions per subunit.

value: Nucleus

value: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily

description: Protein kinase

description: Disordered

description: Disordered

description: Disordered

description: Acidic residues

description: Proton acceptor

value: Expressed in inner cell mass and 23 other cell types or tissues

value: F:non-membrane spanning protein tyrosine kinase activity

value: P:negative regulation of G2/M transition of mitotic cell cycle

value: EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED


value: Dynein light chain Tctex-type 2B

value: Belongs to the dynein light chain Tctex-type family

description: Disordered

description: Basic and acidic residues

value: Thoroughbred

value: Chromosome 19

database: ExpressionAtlas

value: baseline

database: CDD

value: tctex1 domain-containing protein 2

database: InterPro

database: PANTHER

value: DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B

value: T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN

database: Pfam


value: DNA (cytosine-5-)-methyltransferase

name: L-cysteinyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-cysteinyl-[protein] + S-adenosyl-L-homocysteine + H(+)

database: ChEBI

name: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)

value: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family

value: Lacks conserved residue(s) required for the propagation of feature annotation

description: PWWP

description: PHD-type

description: Disordered

description: Disordered

description: Disordered

description: Polar residues

description: Basic and acidic residues

description: Basic residues

description: Polar residues

description: Low complexity

description: Basic and acidic residues

description: Polar residues

description: Basic and acidic residues

value: F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

value: F:RNA polymerase II-specific DNA-binding transcription factor binding

value: P:negative regulation of DNA-templated transcription

value: P:negative regulation of gene expression via chromosomal CpG island methylation

value: P:negative regulation of transcription by RNA polymerase II

value: P:transposable element silencing by piRNA-mediated DNA methylation

value: DNA (Cytosine-5)-methyltransferase 3A isoform X1

value: DNA (Cytosine-5)-methyltransferase 3B isoform 3

value: DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED