entryType: UniProtKB unreviewed (TrEMBL)

proteinExistence: 5: Uncertain

value: Uncharacterized protein

commentType: SUBCELLULAR LOCATION

source: Google

value: GO

value: hydrated

value: Cytoplasm

citationType: unpublished observations


value: Ig-like

value: domain

value: Ig-like domain-containing protein


value: Estradiol 17-beta-dehydrogenase 1

database: GO

key: GoTerm

key: GoEvidenceType


value: PANTHER

value: Roundabout homolog 1

value: substring

value: Membrane


value: KRAB

value: KRAB domain-containing protein

value: Nucleus

value: May be involved in transcriptional regulation

commentType: FUNCTION


value: Secreted


value: SAM

value: SAM domain-containing protein


value: Brix

value: Brix domain-containing protein


value: Uncharacterized protein

value: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code

value: F:dioxygenase activity

value: GO

value: hydrated

value: F:histone H3K9 demethylase activity


value: Peptidase S1

value: domain

value: Peptidase S1 domain-containing protein


value: Collagen-like protein 7

value: Extracellular space

value: Extracellular matrix

value: P:regulation of synaptic assembly at neuromuscular junction

value: P:skeletal muscle acetylcholine-gated channel clustering

value: C:neuromuscular junction

value: P:establishment of protein localization to membrane


value: keyword

value: Membrane


value: PANTHER

value: uracil-DNA glycosylase

value: Mitochondrion

value: Nucleus


value: Uncharacterized protein


value: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides


value: Ig-like

value: domain

value: Ig-like domain-containing protein

value: Involved in the presentation of foreign antigens to the immune system


value: BTB

value: BTB domain-containing protein

value: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes


value: Grh/CP2 DB

value: Grh/CP2 DB domain-containing protein


value: substring

value: Eukaryotic translation initiation factor 1A

value: GO

value: Cytoplasm


value: Membrane

value: hydrated


value: PANTHER

value: Alpha-mannosidase 2


value: Uncharacterized protein

value: P:vesicle-mediated transport


value: ELKS/RAB6-interacting/CAST family member 1

value: ELKS/Rab6-interacting/CAST family member 1


value: Ig-like

value: domain

value: Ig-like domain-containing protein


value: Dimethyladenosine transferase 1, mitochondrial


value: R3H domain and coiled-coil containing 1-like

value: R3H domain-containing protein

value: F:nucleic acid binding


value: PCI

value: PCI domain-containing protein

value: GO

value: Nucleus


value: Membrane


value: PANTHER

value: Amyloid-beta A4 precursor protein-binding family B member 1


value: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

value: GTPase-activating protein for the ADP ribosylation factor family


value: Fanconi anemia group D2 protein


value: Testis-expressed protein 9

value: hydrated

value: Cytoplasm

value: Centrosome

value: Cytoskeleton

value: Microtubule organizing center

Coiled coil

category: Domain


value: Homeobox

value: domain

value: Homeobox domain-containing protein


value: GO


value: Uncharacterized protein

value: keyword

value: F:metal ion transmembrane transporter activity


value: Matrix metalloproteinase-14

value: Cytoplasmic granule


value: Carboxylesterase type B

value: Carboxylesterase type B domain-containing protein

value: Secreted


value: PANTHER

value: Glutathione peroxidase 2

Selenium

category: Ligand


value: Membrane

value: Endoplasmic reticulum membrane

value: May be involved in the transport of sterols


value: BAR

value: BAR domain-containing protein

value: Cytoplasm


value: Solute carrier family 3 member 1


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein

value: F:protein serine/threonine kinase activity

value: hydrated


value: Uncharacterized protein

value: Nucleus


value: PID

value: PID domain-containing protein


value: GO


value: PANTHER

value: Tetratricopeptide repeat protein 34

value: Cytoskeleton


value: SUPFAM

value: substring


value: Signal peptidase complex subunit 2 homolog (S. cerevisiae)

value: Signal peptidase complex subunit 2

value: Endoplasmic reticulum membrane

value: F:peptidase activity

value: P:signal peptide processing

value: C:signal peptidase complex


value: P:pattern specification process

value: hydrated


value: Uncharacterized protein

Transferase

category: Molecular function

value: P:protein transport


value: Immunoglobulin subtype

value: domain

value: Immunoglobulin subtype domain-containing protein


value: PANTHER

value: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

value: GO

value: Membrane

value: F:transferase activity


value: Secreted


value: CDD

value: LysM domain-containing protein


value: keyword


value: Ubiquitin-like

value: Nucleus

value: F:proteasome binding

value: P:proteasome-mediated ubiquitin-dependent protein catabolic process

value: F:ubiquitin binding

value: F:polyubiquitin modification-dependent protein binding


value: Interleukin enhancer-binding factor 3


value: Band 4.1 C-terminal

value: domain

value: Band 4.1 C-terminal domain-containing protein

value: Erythrocyte membrane protein band 4.1 like 2

value: substring


value: Zinc finger protein 354B

value: May be involved in transcriptional regulation

value: GO


value: Uncharacterized protein

value: hydrated


value: Flavodoxin-like


value: keyword

value: Membrane

Glycoprotein

category: PTM


value: Calponin-homology (CH)

value: Calponin-homology (CH) domain-containing protein

value: Extracellular matrix

value: Extracellular space

value: Secreted

value: P:negative regulation of T cell migration

value: P:negative regulation of GTPase activity

value: P:cellular response to chemokine


value: Putative pheromone receptor


value: F:oxidoreductase activity


value: PANTHER

value: Beta-mannosidase

value: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides

value: F:hydrolase activity, acting on glycosyl bonds

value: P:metabolic process


value: Uncharacterized protein

value: Putative odorant or sperm cell receptor


value: ATP-binding cassette sub-family C member 8


value: MaoC-like

value: domain

value: MaoC-like domain-containing protein


value: D-tyrosyl-tRNA(Tyr) deacylase

value: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality


value: Serpin

value: Serpin domain-containing protein

value: Endoplasmic reticulum


value: Calponin-homology (CH)

value: Calponin-homology (CH) domain-containing protein

value: GO

value: substring

value: Cytoskeleton


value: Collagen alpha-1(XIII) chain

value: Secreted

value: Extracellular space

value: Extracellular matrix

value: P:innate immune response


value: domain

value: G-protein coupled receptors family 3 profile domain-containing protein


value: Uncharacterized protein

value: Nucleus

value: F:DNA binding


value: Receptor ligand binding region

value: Receptor ligand binding region domain-containing protein

value: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity


value: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

value: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation

value: hydrated


value: keyword

value: Membrane


value: Cytochrome P450

value: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics


value: Endoplasmic reticulum membrane


value: Deoxyhypusine synthase-like protein


value: LRRCT

value: domain

value: LRRCT domain-containing protein

value: Secreted

value: Membrane raft

value: Golgi apparatus

value: GO


value: Mitochondrion


value: DDB1- and CUL4-associated factor 12-like protein 1


value: Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein


value: Ras GTPase-activating protein nGAP


value: PROSITE

value: C2 domain-containing protein


value: PANTHER

value: substring

value: Protein S100

value: Nucleus


value: Schlafen AlbA-2

value: Schlafen AlbA-2 domain-containing protein


value: Uncharacterized protein

value: P:detection of chemical stimulus involved in sensory perception of taste

value: hydrated


value: Fasciculation and elongation protein zeta-2

value: Cytoskeleton

value: Centrosome

value: Microtubule organizing center

value: Cytoplasm


value: MSP

value: domain

value: MSP domain-containing protein

value: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod


value: Belongs to the aldehyde dehydrogenase family.

value: Aldehyde dehydrogenase domain-containing protein

value: Mitochondrion matrix


value: PANTHER

value: PR domain zinc finger protein 15

value: May be involved in transcriptional regulation


value: Ribosomal protein S11

value: C:ribonucleoprotein complex

value: GO


value: InterPro

value: B30.2/SPRY domain-containing protein


value: KDEL endoplasmic reticulum protein retention receptor 3


value: Uncharacterized protein

value: Sarcomere

value: Myofibril

value: F:actin binding

value: keyword

value: hydrated


value: domain

value: C2H2-type domain-containing protein

value: Nucleus


value: PANTHER

value: Coiled-coil domain-containing protein 158


value: Cyclin-like domain-containing protein

value: Essential for the control of the cell cycle at the G2/M (mitosis) transition

value: Cytoplasm

value: P:regulation of cell cycle


value: Olfactory receptor 4F15


value: InterPro

value: Doublecortin domain-containing protein


value: Uncharacterized protein

value: Endoplasmic reticulum membrane

value: May be involved in the transport of sterols


value: Zinc finger MYND domain-containing protein 8

value: keyword


value: Mitotic-spindle organizing protein 2B

value: C:microtubule organizing center

value: GO

value: hydrated


value: Interleukin-1 receptor-associated kinase 4

value: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization


value: C:cell surface


value: FERM domain-containing protein


value: PROSITE

value: BTB domain-containing protein


value: Membrane


value: Nucleus


value: Uncharacterized protein


value: Pre-mRNA-splicing factor CEF1


value: TAFH domain-containing protein


value: PANTHER

value: Transmembrane channel-like protein 1


value: Tudor

value: domain

value: Tudor domain-containing protein

value: Neuron projection

value: Perikaryon

value: Cytoplasm

value: Myofibril

value: Cell projection


value: Pfam

value: Uteroglobin


value: F:DNA-binding transcription factor activity

value: GO

value: hydrated

value: P:apoptotic process


value: LIM zinc-binding

value: LIM zinc-binding domain-containing protein

value: Cytoskeleton


value: Uncharacterized protein


value: keyword

value: Membrane

value: P:immune response

value: C:extracellular space


value: Fibroblast growth factor 18

value: Secreted


value: RNase NYN

value: domain

value: RNase NYN domain-containing protein

value: substring

value: Cytoplasm

value: F:RNA binding


value: Formin-binding protein 1-like


value: Shieldin complex subunit 2 C-terminal

value: Shieldin complex subunit 2 C-terminal domain-containing protein

value: Nucleus

value: Chromosome

value: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres

value: C:site of double-strand break

value: P:negative regulation of double-strand break repair via homologous recombination

value: P:positive regulation of isotype switching

value: P:positive regulation of double-strand break repair via nonhomologous end joining

value: C:actin cytoskeleton


value: C3H1-type domain-containing protein


value: Non-SMC condensin I complex subunit H


value: WD repeat-containing protein 92

value: Cytoskeleton

value: GO

value: Cleavage furrow

value: C:RPAP3/R2TP/prefoldin-like complex


value: PANTHER

value: Rab11 family-interacting protein 1

value: keyword

value: Membrane

value: Endosome membrane


value: Uncharacterized protein


value: InterPro

value: Thioredoxin domain-containing protein


value: Ral guanine nucleotide dissociation stimulator-like 1

value: Nucleus


value: Calmodulin-regulated spectrin-associated protein 1


value: HELP

value: domain

value: HELP domain-containing protein

value: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic


value: GO


value: C:anchoring junction

value: hydrated


value: F:structural constituent of ribosome


value: SPATA31 domain-containing protein


value: EF-hand domain-containing protein

value: May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom


value: EGF-like

value: EGF-like domain-containing protein

value: Secreted

Cell adhesion

category: Biological process


value: RRM

value: RRM domain-containing protein


value: Uncharacterized protein

value: Nucleus


value: PANTHER

value: Keratin-associated protein 10-8

value: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins


value: Ras and Rab interactor 3

value: GO

value: Membrane


value: domain

value: Major facilitator superfamily (MFS) profile domain-containing protein


value: InterPro

value: Ig-like domain-containing protein


value: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1


value: Serpin

value: Serpin domain-containing protein


value: E2F/DP family winged-helix DNA-binding

value: E2F/DP family winged-helix DNA-binding domain-containing protein

value: hydrated

value: C:transcription regulator complex


value: PROSITE

value: WH1 domain-containing protein


value: PANTHER

value: WD repeat-containing and planar cell polarity effector protein fritz homolog

value: P:cell projection organization

value: keyword


value: Ig-like

value: domain

value: GO


value: Xylulokinase

value: Cytoplasm


value: AP complex mu/sigma subunit

value: AP complex mu/sigma subunit domain-containing protein

value: Cytoplasmic vesicle membrane

value: substring

value: Membrane


value: HMG box

value: HMG box domain-containing protein

value: Nucleus


value: Protein kinase

value: Protein kinase domain-containing protein

value: Cytoskeleton


value: PANTHER

value: BPI fold-containing family A member 1


value: IF rod

value: domain

value: IF rod domain-containing protein


value: InterPro

value: SH2 domain-containing protein

value: Endoplasmic reticulum


value: eIF-4F 25 kDa subunit

value: GO

value: hydrated

value: Cytoplasm

value: F:RNA binding

value: keyword


value: SOCS box

value: SOCS box domain-containing protein

value: Centrosome

value: Microtubule organizing center

value: Myofibril


value: PANTHER


value: Uncharacterized protein

value: F:metal ion binding


value: L1 transposable element RRM

value: domain

value: L1 transposable element RRM domain-containing protein

value: Nucleus


value: Succinate dehydrogenase assembly factor 2, mitochondrial

value: Mitochondrion matrix

value: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer

value: P:protein-FAD linkage

value: C:mitochondrial matrix

value: P:mitochondrial electron transport, succinate to ubiquinone


value: Protein phosphatase 1 regulatory subunit 32

value: C:ciliary basal body

value: F:phosphatase binding


value: Geranylgeranyl transferase type-2 subunit beta


value: Ankyrin repeat domain 1 (cardiac muscle)

value: substring

value: Ankyrin repeat domain 1


value: Fibronectin type-III

value: Fibronectin type-III domain-containing protein


value: Tropomyosin alpha-3 chain


value: Zinc finger protein 665

value: May be involved in transcriptional regulation


value: Poly A polymerase head

value: domain

value: Poly A polymerase head domain-containing protein


value: Uncharacterized protein

value: Secreted


value: RRM

value: RRM domain-containing protein


value: PANTHER

value: Coiled-coil domain-containing protein 30


value: FHA

value: FHA domain-containing protein

value: Cytoskeleton


value: Mitochondrion

value: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane


value: KRAB

value: KRAB domain-containing protein

value: Nucleus


value: P:DNA recombination

value: keyword

value: hydrated


value: PROSITE


value: Pfam

value: Serpin domain-containing protein

value: Secreted


value: DEP domain-containing protein


value: PLD phosphodiesterase

value: domain

value: PLD phosphodiesterase domain-containing protein

value: GO

value: Membrane

value: C:intracellular organelle


value: Uncharacterized protein


value: Centriole

value: Microtubule organizing center

value: Centrosome

value: Cell projection

value: substring

value: Cytoskeleton

value: Cilium


value: hydrated


value: Coiled-coil

value: Coiled-coil domain-containing protein


value: Pfam

value: C2 domain-containing protein

value: P:heart development

value: P:smoothened signaling pathway

value: P:kidney development

value: P:neural tube closure


value: F-BAR

value: domain

value: F-BAR domain-containing protein


value: PANTHER

value: C-type lectin domain-containing protein

value: F:carbohydrate binding

value: GO


value: Bardet-Biedl syndrome 1 N-terminal

value: Bardet-Biedl syndrome 1 N-terminal domain-containing protein


value: Cationic amino acid transporter 4

value: Probable amino-acid or metabolite transport protein

value: F:transmembrane transporter activity

value: hydrated


value: Uncharacterized protein

value: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex

value: keyword

value: Membrane


value: HotDog ACOT-type

value: HotDog ACOT-type domain-containing protein

value: Mitochondrion


value: Granzyme H

value: Cytoplasmic granule

value: Secreted


value: PANTHER

value: Fibroblast growth factor receptor 2


value: May be involved in transcriptional regulation

value: Nucleus


value: Cadherin

value: domain

value: Cadherin domain-containing protein


value: Uncharacterized protein


value: ATP-binding cassette sub-family C member 8


value: Neurotransmitter-gated ion-channel ligand-binding domain-containing protein


value: eIF-4F 25 kDa subunit

value: GO

value: Cytoplasm


value: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors


value: keyword

value: Membrane


value: C2H2-type domain-containing protein

value: F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

value: P:regulation of transcription by RNA polymerase II

value: F:DNA-binding transcription activator activity, RNA polymerase II-specific


value: Nucleus

value: Centromere

value: hydrated

value: Chromosome

value: Kinetochore


value: Uncharacterized protein

value: C:extracellular region


value: T-box

value: domain

value: T-box domain-containing protein

value: F:DNA-binding transcription factor activity

value: P:positive regulation of DNA-templated transcription

value: P:embryo development


value: PANTHER

value: Tensin


value: BPTI/Kunitz inhibitor

value: BPTI/Kunitz inhibitor domain-containing protein

value: Secreted


value: Nucleus

value: Nucleolus

value: keyword

value: Cytoplasm


value: Cationic amino acid transporter 4

value: Probable amino-acid or metabolite transport protein

value: F:transmembrane transporter activity

value: GO

value: hydrated


value: Uncharacterized protein

value: P:regulation of monoatomic ion transmembrane transport


value: CW-type

value: domain

value: CW-type domain-containing protein


value: Protein kinase

value: Protein kinase domain-containing protein

value: Dendrite

value: Cell projection


value: MEF2 activating motif and SAP domain containing transcriptional regulator

value: substring

value: MEF2 activating motif domain-containing protein


value: UBA

value: UBA domain-containing protein


value: PANTHER

value: Alpha-soluble NSF attachment protein


value: Fibronectin type-III

value: Fibronectin type-III domain-containing protein


value: Glutamate-rich protein 3


value: PHD-type

value: PHD-type domain-containing protein

value: Nucleus

Nucleus

category: Cellular component


value: Cilia- and flagella-associated protein 298


value: RING-type

value: domain

value: RING-type domain-containing protein


value: 5'-nucleotidase, cytosolic II


value: Uncharacterized protein

value: Vacuole membrane


value: Potassium channel subfamily T member 1

value: Potassium channel


value: WHEP-TRS

value: WHEP-TRS domain-containing protein

value: Mitochondrion matrix


value: PANTHER

value: Guanine nucleotide-binding protein G(O) subunit alpha


value: Longin

value: Longin domain-containing protein

value: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity

value: Endomembrane system

value: substring

value: Membrane

value: Cytoplasmic vesicle membrane

value: Golgi apparatus membrane


value: RRM

value: domain

value: RRM domain-containing protein


value: Cathepsin C exclusion

value: Cathepsin C exclusion domain-containing protein

value: C:extracellular region


value: Uncharacterized protein

value: F:kinase activity

value: Microtubule affinity regulating kinase 3

value: hydrated


value: Cathepsin propeptide inhibitor

value: Cathepsin propeptide inhibitor domain-containing protein

value: Secreted

value: F:cysteine-type endopeptidase inhibitor activity


value: Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein

value: Mitochondrion matrix

value: P:carboxylic acid catabolic process


value: Endoplasmic reticulum lumen


value: domain

value: AMMECR1 domain-containing protein

value: Nucleus


value: PANTHER

value: Interferon-induced protein with tetratricopeptide repeats 2

value: Cytoskeleton

value: C:endoplasmic reticulum


value: G-protein coupled receptors family 1 profile domain-containing protein


value: Thioredoxin

value: Thioredoxin domain-containing protein

Disulfide bond

value: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity.

value: hydrated


value: Uncharacterized protein

value: GO

value: Membrane

value: Endoplasmic reticulum membrane


value: Protein kinase

value: Protein kinase domain-containing protein


value: Endoplasmic reticulum lectin 1


value: Retinoic acid receptor alpha

value: Nucleus


value: USP

value: domain

value: USP domain-containing protein


value: P:lipid metabolic process


value: LIM zinc-binding

value: LIM zinc-binding domain-containing protein

value: substring

value: Cytoplasm


value: Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein


value: Uncharacterized protein

value: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome


value: Cystatin fetuin-A-type

value: Cystatin fetuin-A-type domain-containing protein


value: EF-hand

value: EF-hand domain-containing protein


value: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'

value: GO

value: hydrated


value: Myotubularin phosphatase

value: domain

value: Myotubularin phosphatase domain-containing protein

value: keyword

value: Membrane


value: PANTHER

value: Transcription factor p65

value: Nucleus


value: Uncharacterized protein

value: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA

value: Cytoplasm


value: SOCS box domain-containing protein

value: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins


value: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

value: substring

value: Putative pheromone receptor


value: Glycosyltransferase 2-like

value: Glycosyltransferase 2-like domain-containing protein


value: GO


value: Myosin-binding protein C, slow-type


value: Receptor expression-enhancing protein 4


value: InterPro

value: PH domain-containing protein

value: Membrane


value: hydrated

value: Cytosol

value: Cytoskeleton


value: Uncharacterized protein

value: keyword


value: RING-type

value: domain

value: RING-type domain-containing protein

value: Cytoplasm


value: Serpin

value: Serpin domain-containing protein

value: Extracellular space

value: Secreted


value: PANTHER

value: Spermatogenesis-associated protein 19, mitochondrial


value: RGS

value: RGS domain-containing protein


value: MENTAL

value: MENTAL domain-containing protein


value: PAP-associated

value: GO

value: hydrated

value: P:nuclear-transcribed mRNA poly(A) tail shortening

value: P:mRNA processing

value: F:RNA binding


value: Splicing factor U2AF 26 kDa subunit

value: Nucleus


value: domain

value: RRN7-type domain-containing protein

value: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3

value: Nucleolus

value: C:RNA polymerase I core factor complex

value: F:metal ion binding

value: F:RNA polymerase I core promoter sequence-specific DNA binding


value: PANTHER

value: A disintegrin and metalloproteinase with thrombospondin motifs 3

value: keyword

value: C:extracellular region


value: G-protein coupled receptors family 3 profile domain-containing protein

value: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity


value: Nucleolar and spindle-associated protein 1

value: hydrated


value: Uncharacterized protein

value: GO

value: Cytoplasm


value: PIGA GPI anchor biosynthesis

value: domain

value: PIGA GPI anchor biosynthesis domain-containing protein

value: substring

value: Membrane

value: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis


value: InterPro

value: DPY30 domain-containing protein


value: PANTHER

value: NAD kinase


value: Protein FAM184A/B N-terminal

value: Protein FAM184A/B N-terminal domain-containing protein


value: Aminopeptidase P N-terminal

value: Aminopeptidase P N-terminal domain-containing protein

value: Mitochondrion

value: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides


value: Striatin N-terminal

value: Striatin N-terminal domain-containing protein


value: Protein FAM76A


value: Inactive tyrosine-protein kinase 7

value: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons


value: Guanine nucleotide exchange factor VAV2

value: GO

value: Cytoplasm

value: Cytoskeleton

value: P:intracellular signal transduction

value: hydrated


value: Uncharacterized protein


value: F:very-long-chain enoyl-CoA reductase activity

value: very-long-chain enoyl-CoA reductase


value: FERM

value: domain

value: FERM domain-containing protein

value: Cell junction

value: Adherens junction


value: keyword


value: PANTHER

value: GRIP1-associated protein 1

value: F:identical protein binding


value: B30.2/SPRY domain-containing protein


value: GO


value: substring

value: Guanine nucleotide-binding protein subunit alpha


value: Nucleus


value: Etoposide-induced protein 2.4 homolog


value: Nuclear factor NF-kappa-B p105 subunit

value: F:DNA binding

value: hydrated

value: P:signal transduction


value: Uncharacterized protein

value: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites


value: Glutamate receptor ionotropic, kainate 3


value: Protein FAM76A


value: LIM zinc-binding

value: domain

value: LIM zinc-binding domain-containing protein


value: 2'-5'-oligoadenylate synthetase 1

value: 2'-5'-oligoadenylate synthetase 1 domain-containing protein

value: F:double-stranded RNA binding


value: Gamma-glutamylamine cyclotransferase


value: EF-hand

value: EF-hand domain-containing protein

value: Endoplasmic reticulum

value: Endomembrane system

value: Cytoskeleton


value: GO

value: hydrated

value: Cytoplasm


value: Uncharacterized protein

value: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.

value: substring

value: P:protein catabolic process


value: PANTHER

value: Myb-binding protein 1A


value: Tyrosine--tRNA ligase, mitochondrial

value: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

value: Mitochondrion matrix

value: P:tyrosyl-tRNA aminoacylation


value: Arf-GAP

value: domain

value: Arf-GAP domain-containing protein

value: Target cell membrane

value: Secreted

value: GTPase-activating protein for the ADP ribosylation factor family


value: Aftiphilin clathrin-binding box

value: Aftiphilin clathrin-binding box domain-containing protein


value: Pre-mRNA-processing factor 40 homolog A

value: GO

value: Nucleus


value: Phosphatase tensin-type

value: Phosphatase tensin-type domain-containing protein


value: L-type lectin-like

value: L-type lectin-like domain-containing protein


value: Disintegrin

value: Disintegrin domain-containing protein


value: Peptidase M12B

value: Peptidase M12B domain-containing protein


value: Uncharacterized protein

value: P:protein phosphorylation

value: hydrated


value: PANTHER

value: Presenilin

value: keyword

value: Membrane

value: Golgi apparatus membrane


value: Syntaxin N-terminal

value: domain

value: Syntaxin N-terminal domain-containing protein


value: Late endosome membrane

value: Trans-Golgi network membrane

value: cis-Golgi network membrane

value: Cis-Golgi network membrane


value: P:cell cycle

value: GO


value: Uncharacterized protein

value: Nucleus


value: PX

value: PX domain-containing protein


value: DH

value: DH domain-containing protein


value: Cyclin-dependent kinase 20

value: hydrated

value: Cytoplasm

value: F:cyclin-dependent protein serine/threonine kinase activity

value: P:protein phosphorylation


value: domain

value: Potassium channel tetramerisation-type BTB domain-containing protein


value: P:immune response

value: C:extracellular space


value: BTB

value: BTB domain-containing protein


value: EGF-like

value: EGF-like domain-containing protein

value: keyword

value: Membrane


value: Uncharacterized protein

value: Mitochondrion


value: PANTHER

value: Cytochrome c oxidase assembly factor 1 homolog

value: Mitochondrion inner membrane


value: P:cell division


value: GO

value: hydrated


value: domain

value: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein

value: P:spliceosomal snRNP assembly

value: P:protein ubiquitination

value: F:RNA 7-methylguanosine cap binding

value: F:mRNA 3'-UTR binding

value: P:regulation of translation


value: keyword

Cell membrane

value: Cell membrane


value: Uncharacterized protein

value: P:nucleic acid metabolic process


value: DUF5009 domain-containing protein

value: Membrane


value: MARVEL

value: MARVEL domain-containing protein


value: Nuclear RNA export factor 1

value: GO

value: Cytoplasm


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein

value: P:protein phosphorylation


value: Synapse

value: P:positive regulation of GTPase activity


value: Insulin receptor substrate 1


value: C2 domain-containing protein


value: Uncharacterized protein

Nucleus

value: Nucleus

value: hydrated


value: Peptidase M48

value: Peptidase M48 domain-containing protein

value: keyword

value: Membrane


value: GO


value: Importin N-terminal

value: Importin N-terminal domain-containing protein


value: Leucine-rich repeat-containing protein 15

value: Membrane raft

value: Secreted

value: Golgi apparatus

value: P:toll-like receptor signaling pathway

value: P:immune response

value: F:transmembrane signaling receptor activity


value: procollagen-proline 4-dioxygenase


value: Uncharacterized protein


value: Mitochondrion


value: F:A2-type glycerophospholipase activity

value: F:glycerophospholipid phospholipase A1 activity


value: Cilium basal body

value: Cytoskeleton

value: C:cell projection

value: keyword

value: hydrated


value: START

value: domain

value: START domain-containing protein


value: Shieldin complex subunit 2 C-terminal

value: Shieldin complex subunit 2 C-terminal domain-containing protein

value: Chromosome

value: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres

value: Nucleus

value: P:positive regulation of double-strand break repair via nonhomologous end joining

value: C:actin cytoskeleton

value: C:site of double-strand break

value: P:negative regulation of double-strand break repair via homologous recombination

value: P:positive regulation of isotype switching


value: IRS-type PTB

value: IRS-type PTB domain-containing protein

value: P:positive regulation of MAPK cascade

value: P:cell surface receptor protein tyrosine kinase signaling pathway

value: P:nervous system development


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein

value: P:protein phosphorylation


value: Ubiquitin-like protease family profile

value: Ubiquitin-like protease family profile domain-containing protein

value: Nucleolus


value: PANTHER

value: Protein FAM81A


value: Uncharacterized protein

value: May be involved in transcriptional regulation

value: GO

value: Nucleus


value: InterPro

value: Meckelin

value: keyword

value: Membrane


value: F:RNA-directed DNA polymerase activity


value: Ubiquitin-like

value: domain


value: CBS

value: CBS domain-containing protein

value: hydrated


value: Kinesin light chain 3


value: eIF-4F 25 kDa subunit

value: Cytoplasm


value: SCAN box

value: SCAN box domain-containing protein


value: P-type ATPase N-terminal

value: P-type ATPase N-terminal domain-containing protein

value: SUPFAM

value: substring

value: F:ATP hydrolysis activity

value: F:ATPase-coupled intramembrane lipid transporter activity

value: F:ATP binding


value: Peptidase C1A papain C-terminal

value: Peptidase C1A papain C-terminal domain-containing protein


value: Poly [ADP-ribose] polymerase 3

value: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks


value: BZIP

value: domain

value: BZIP domain-containing protein

value: keyword

value: Nucleus


value: PH

value: PH domain-containing protein

value: P:regulation of interleukin-6 production

value: P:positive regulation of DNA-templated transcription

value: P:regulation of mitotic cell cycle

value: F:protein tyrosine kinase activator activity

value: P:positive regulation of interleukin-8 production

value: F:SH2 domain binding

value: F:SH3 domain binding

value: P:inflammatory response

value: P:positive regulation of epidermal growth factor receptor signaling pathway


value: Uncharacterized protein

value: Secreted


value: Mitochondrion matrix

value: F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity


value: Phospholipase A2

value: domain

value: Phospholipase A2 domain-containing protein


value: J

value: J domain-containing protein

value: Endoplasmic reticulum


value: P:carbohydrate transport

value: keyword

value: hydrated


value: Tissue-type plasminogen activator


value: Protein kinase

value: Protein kinase domain-containing protein

value: P:protein phosphorylation


value: Immunoglobulin lambda constant 1

value: F:antigen binding

value: C:IgG immunoglobulin complex

value: P:immunoglobulin mediated immune response


value: Uncharacterized protein

value: Nucleus

value: P:cell cycle


value: RALB

value: RALB protein

value: GO

value: substring

value: Membrane


value: Golgin subfamily A member 7/ERF4

value: domain

value: Golgin subfamily A member 7/ERF4 domain-containing protein


value: DEAD-box ATP-dependent RNA helicase 28

value: RNA helicase


value: F-box

value: F-box domain-containing protein

value: Cytoplasm

value: P:G2/M transition of mitotic cell cycle

value: P:protein polyubiquitination

value: C:SCF ubiquitin ligase complex

value: P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process


value: SOCS box

value: SOCS box domain-containing protein

value: Target cell membrane

value: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins


value: InterPro

value: hydrated

value: Spindle assembly checkpoint component MAD1


value: Uncharacterized protein

value: GO


value: domain

value: C2H2-type domain-containing protein

value: May be involved in transcriptional regulation


value: PANTHER

value: Protein EFR3 homolog A

value: P:protein localization to plasma membrane


value: Cadherin

value: Cadherin domain-containing protein

value: F:X11-like protein binding

value: F:kinesin binding

value: F:amyloid-beta binding


value: Serine/threonine-protein phosphatase 4 regulatory subunit 2

value: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4C)

value: Cytoskeleton


value: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity


value: Uncharacterized protein

value: Secreted


value: LysM

value: domain

value: LysM domain-containing protein


value: Nucleus

value: Major role in the synthesis of nucleoside triphosphates other than ATP

value: Cell projection

value: Ruffle

value: Lamellipodium

value: keyword

value: hydrated


value: Tetraspanin


Transmembrane

value: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

value: GO


value: PANTHER

value: Regulator of G-protein signaling 7


value: Anion exchange protein 2

value: Cell membrane

value: C:plasma membrane


value: EGF-like

value: domain

value: EGF-like domain-containing protein


value: Leucine-rich repeat-containing protein 71

value: Cytoskeleton


value: Serine/threonine-protein phosphatase 4 regulatory subunit 4

value: Nucleus

value: Spindle

value: P:blastocyst hatching

value: F:protein phosphatase regulator activity

value: C:protein serine/threonine phosphatase complex


value: RRM

value: RRM domain-containing protein


value: Myb/SANT-like DNA-binding

value: Myb/SANT-like DNA-binding domain-containing protein

value: F:DNA binding

value: Myb/SANT DNA binding domain containing 2

value: hydrated


value: domain

value: Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein

value: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn)

value: GO

value: Cytoplasm


value: Uncharacterized protein


value: Peptidase S1

value: Peptidase S1 domain-containing protein

value: Secreted


value: Ig-like

value: Ig-like domain-containing protein


value: WH2 domain-containing protein


value: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis


value: SAM

value: SAM domain-containing protein


value: AAA+ ATPase

value: AAA+ ATPase domain-containing protein

value: Probable ATP-dependent zinc metallopeptidase

value: Mitochondrion inner membrane

value: keyword

value: Membrane


value: DH

value: domain

value: DH domain-containing protein


value: Protein kinase

value: Protein kinase domain-containing protein

value: Cell projection

value: P:protein phosphorylation

value: GO

value: hydrated


value: PANTHER

value: Sorting nexin-1

value: Early endosome membrane

value: substring

value: Endosome membrane


value: Gelsolin-like

value: Gelsolin-like domain-containing protein

value: Cytoskeleton

value: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis


value: Uncharacterized protein

value: keyword

value: Membrane

value: F:protein kinase inhibitor activity


value: C:microtubule organizing center


value: Zinc finger protein 552

value: May be involved in transcriptional regulation

value: F:metal ion binding


value: ATP-grasp domain-containing protein

value: Cell projection


value: P:cell cycle

value: hydrated


value: domain

value: Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein


value: F:protein tyrosine/serine/threonine phosphatase activity


value: C:lipid droplet


value: Olfactomedin-like

value: Synapse

value: P:extracellular matrix organization

value: F:identical protein binding

value: C:extracellular matrix

value: F:extracellular matrix binding


value: PDZ

value: PDZ domain-containing protein

value: Membrane associated guanylate kinase, WW and PDZ domain containing 3

value: substring

value: Membrane


value: PANTHER

value: Protein LYRIC

value: keyword


value: Deacetylase sirtuin-type

value: domain

value: Deacetylase sirtuin-type domain-containing protein

value: GO

value: Nucleus

value: F:transferase activity

value: hydrated


value: Uncharacterized protein

value: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells

value: Secreted


value: PID

value: PID domain-containing protein

value: P:ventral spinal cord development


value: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain

value: Apical cell membrane

value: P:hormone biosynthetic process

value: P:hydrogen peroxide catabolic process

value: P:thyroid hormone generation

value: F:calcium ion binding


value: FERM

value: domain

value: FERM domain-containing protein

value: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation


value: Protein C-ets-1


value: Uncharacterized protein

value: GO

value: hydrated

value: Membrane


value: Grh/CP2 DB

value: Grh/CP2 DB domain-containing protein

value: Nucleus

value: F:DNA binding


value: Major facilitator superfamily (MFS) profile domain-containing protein

value: keyword


value: Ig-like

value: Ig-like domain-containing protein


value: FH2 domain-containing protein

value: Cytoskeleton


value: P:nucleic acid metabolic process


value: Belongs to the dynein light chain Tctex-type family.

value: Dynein light chain Tctex-type domain-containing protein

value: C:ciliary base

value: F:dynein intermediate chain binding

value: C:spindle pole

value: P:intraciliary retrograde transport

value: P:regulation of intraciliary retrograde transport

value: P:cilium assembly

value: C:interphase microtubule organizing center

value: P:regulation of cilium assembly


value: Uncharacterized protein

value: F:RNA-directed DNA polymerase activity


value: P:cell cycle

value: keyword

value: hydrated


value: ADP-ribosylation factor-like protein 2


value: Membrane


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein

value: P:protein phosphorylation


value: PANTHER

value: substring

value: Kinetochore-associated protein

value: Centromere

value: Kinetochore

value: Nucleus

value: GO

value: Chromosome


value: Rhodanese

value: Rhodanese domain-containing protein


value: Uncharacterized protein

value: keyword

value: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor


value: Mitochondrial carrier homolog 2

value: Membrane

value: hydrated


value: Myotubularin phosphatase

value: domain

value: Myotubularin phosphatase domain-containing protein

value: P:positive regulation of phosphatase activity

value: P:negative regulation of autophagy

value: P:protein stabilization

value: C:protein-containing complex

value: F:protein phosphatase binding

value: F:enzyme regulator activity

value: P:regulation of phosphatidylinositol dephosphorylation


value: Grainyhead-like protein 1 homolog

value: Nucleus


value: Uncharacterized protein

value: keyword


value: Cytochrome P450


value: PANTHER

value: Receptor-type tyrosine-protein phosphatase N2

value: Membrane

value: P:protein dephosphorylation


value: GO

value: hydrated


value: Cadherin

value: domain

value: Cadherin domain-containing protein

value: F:amyloid-beta binding

value: F:kinesin binding

value: C:postsynaptic membrane

value: F:X11-like protein binding


value: Fanconi anemia group C protein homolog

value: Nucleus


value: Ubiquitin carboxyl-terminal hydrolase

value: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes

value: P:ubiquitin-dependent protein catabolic process


value: LRRNT

value: LRRNT domain-containing protein


value: Uncharacterized protein

value: P:regulation of gene expression


value: P:protein phosphorylation


value: keyword

value: Membrane


value: MPN

value: domain

value: MPN domain-containing protein

value: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation


value: V-SNARE coiled-coil homology

value: V-SNARE coiled-coil homology domain-containing protein

value: Vesicle associated membrane protein 1

value: hydrated


value: PANTHER

value: Protein CIP2A

value: F:protein homodimerization activity


value: BZIP

value: BZIP domain-containing protein

value: Nucleus


value: Beta/gamma crystallin 'Greek key'

value: Beta/gamma crystallin 'Greek key' domain-containing protein


value: VWFC

value: VWFC domain-containing protein

value: Secreted


value: substring

value: V-type proton ATPase subunit

value: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment


value: Fork-head

value: domain

value: Fork-head domain-containing protein

value: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints)


value: SCAN box

value: SCAN box domain-containing protein

value: May be involved in transcriptional regulation


value: Calcineurin-like phosphoesterase

value: Calcineurin-like phosphoesterase domain-containing protein


value: PANTHER


value: Uncharacterized protein


value: NUMB

value: NUMB domain-containing protein


value: Env polyprotein

value: The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane

value: keyword

value: Membrane


value: Nucleus

value: F:nucleotide binding

value: hydrated


value: Ubiquitin-associated protein 1

value: GO

value: Cytoplasm


value: F-box

value: domain

value: F-box domain-containing protein

value: P:regulation of autophagy

value: C:SCF ubiquitin ligase complex

value: F:protein phosphatase binding

value: P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

value: P:protein monoubiquitination


value: Uncharacterized protein

value: C:T cell receptor complex

value: P:adaptive immune response

value: P:cell surface receptor signaling pathway

value: C:plasma membrane


value: Ubiquitin-like protease family profile

value: Ubiquitin-like protease family profile domain-containing protein


value: PANTHER

value: substring

value: S-adenosyl-methyltransferase

value: GO

value: hydrated


value: EF-hand

value: domain

value: EF-hand domain-containing protein

value: Cytoskeleton

value: Cytoplasm

value: May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom


value: Uncharacterized protein

value: Secreted

value: F:carbohydrate binding

value: keyword


value: P:regulation of gene expression

value: Nucleus


value: DNA-directed RNA polymerase I subunit RPA2

value: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft

value: Virion


value: Nucleoporin NSP1-like C-terminal

value: Nucleoporin NSP1-like C-terminal domain-containing protein


value: Protein kinase

value: Protein kinase domain-containing protein

value: P:protein phosphorylation


value: Ral guanine nucleotide dissociation stimulator-like 1


value: Helicase ATP-binding

value: domain

value: Helicase ATP-binding domain-containing protein

value: F:ATP-dependent chromatin remodeler activity


value: Uncharacterized protein

Cytoplasm

value: Cytoplasm

value: hydrated

value: GO


value: Envelope glycoprotein

value: Virion membrane

value: C:viral envelope

value: keyword


value: Membrane


value: SSD

value: SSD domain-containing protein


value: Golgi apparatus membrane

value: Microtubule organizing center

value: Cytoskeleton


value: PANTHER

value: LIM domain kinase 1

value: C:intracellular organelle

value: P:protein phosphorylation


value: Collagen alpha-1(I) chain


value: Nuclear envelope integral membrane protein 1

Nucleus

value: Nucleus inner membrane

value: hydrated


value: Uncharacterized protein

value: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

value: substring

value: Cytoplasm


value: Aminopeptidase P N-terminal

value: domain

value: Aminopeptidase P N-terminal domain-containing protein


value: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids


value: Nucleus


value: GTP-binding protein 5

value: Mitochondrion matrix


value: Cell projection

value: Lamellipodium

value: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway


value: RHD

value: RHD domain-containing protein

value: PANTHER


value: Uncharacterized protein

value: hydrated

Hydrolase

value: GO


value: MAGE

value: MAGE domain-containing protein


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein

value: substring

value: Cytoplasm

value: P:protein phosphorylation


value: Nucleus


value: Homeobox

value: Homeobox domain-containing protein

value: P:regulation of DNA-templated transcription

value: F:DNA binding


value: GAE

value: GAE domain-containing protein

value: Golgi apparatus membrane

value: Clathrin-coated vesicle membrane

value: Cytoplasmic vesicle

value: Membrane


value: Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein


value: AB hydrolase-1

value: domain

value: AB hydrolase-1 domain-containing protein

value: Serine hydrolase involved in the detoxification of formaldehyde


value: Choloylglycine hydrolase/NAAA C-terminal domain-containing protein

value: Lysosome

value: F:fatty acid amide hydrolase activity

value: P:fatty acid metabolic process


value: SUPFAM

value: substring

value: Protein kinase domain-containing protein


value: Mannose-6-phosphate isomerase

value: mannose-6-phosphate isomerase


value: SCP

value: SCP domain-containing protein

value: Secreted

value: Probably involved in the defense reaction of plants against pathogens

value: C:extracellular region


value: Metallo-beta-lactamase

value: domain

value: Mitochondrion matrix

value: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid


value: RHD

value: RHD domain-containing protein


value: Kelch-like protein 29

value: GO

value: Cytoplasm


value: Schwannomin interacting protein 1 C-terminal domain-containing protein

value: substring

value: Membrane


value: PANTHER

value: Actin-binding LIM protein 1


value: U-box

value: U-box domain-containing protein

value: P:protein ubiquitination

value: hydrated


value: Catenin delta-2


value: Mitogen-activated protein kinase kinase kinase 13

value: Protein kinase domain-containing protein

value: F:kinase activity


value: Uncharacterized protein

value: Nucleus


value: domain

value: Major facilitator superfamily (MFS) profile domain-containing protein


value: MAGUK p55 subfamily member 2

value: C:plasma membrane

value: GO

value: C:bicellular tight junction


value: MADS-box

value: MADS-box domain-containing protein

value: P:DNA-templated transcription

value: P:positive regulation of transcription by RNA polymerase II


value: Insulin-like

value: Insulin-like domain-containing protein

value: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

value: Secreted


value: AIG1-type G

value: AIG1-type G domain-containing protein


value: C2H2-type domain-containing protein

value: May be involved in transcriptional regulation

value: F:DNA-binding transcription activator activity, RNA polymerase II-specific


value: Protein phosphatase 1 regulatory subunit 7

value: Cytoplasm


value: FERM

value: domain

value: FERM domain-containing protein

value: GO

value: hydrated

value: Cytoskeleton


value: Transmembrane protein 92

value: chain

value: keyword

value: Membrane


value: Uncharacterized protein

value: P:protein transport

value: C:plasma membrane


value: Cis-Golgi network

value: C:Golgi apparatus


value: P:G protein-coupled receptor signaling pathway


value: G-protein coupled receptors family 3 profile domain-containing protein

value: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity


value: AB hydrolase-1

value: domain

value: AB hydrolase-1 domain-containing protein


value: Putative odorant or sperm cell receptor


value: NADP-dependent oxidoreductase

value: NADP-dependent oxidoreductase domain-containing protein

value: GO

value: Cytosol

value: Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway

value: hydrated

value: Cytoplasm


value: Uncharacterized protein

value: Nucleus

value: May be involved in transcriptional regulation

value: P:regulation of DNA-templated transcription


value: PANTHER

value: G-protein coupled receptor-associated protein LMBRD2


value: RING-type

value: RING-type domain-containing protein


value: PROSITE

value: BHLH domain-containing protein


value: F:DNA-binding transcription factor activity


value: Lysozyme g-like protein 1

value: Secreted


value: May be involved in the transport of sterols

value: GO

value: substring

value: Membrane

value: F:lipid binding


value: domain

value: G-protein coupled receptors family 1 profile domain-containing protein


value: Tudor domain-containing protein 1

value: Cytoplasm


value: Uncharacterized protein


value: P:defense response to bacterium

value: keyword

value: hydrated


value: F:DNA binding

value: P:nervous system development

value: P:cell differentiation

value: P:regulation of DNA-templated transcription


value: Cilium axoneme

value: Cytoskeleton


value: C:Golgi apparatus

value: GO


value: Olfactory receptor 7E24

value: Putative odorant or sperm cell receptor


value: Dynamin-binding protein

value: Golgi apparatus

value: Cell junction

value: Golgi stack

value: P:intracellular signal transduction


value: Uncharacterized protein

value: Transmembrane protein 70

value: substring

value: Membrane

value: Mitochondrion inner membrane


value: ATP-grasp

value: domain

value: ATP-grasp domain-containing protein

value: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities


value: Cytoskeleton

value: Centrosome

value: Microtubule organizing center


value: keyword

Transferase

value: GO

value: hydrated

value: P:fatty acid biosynthetic process


value: Nucleus


value: PANTHER

value: DNA helicase B


value: Lysophospholipid acyltransferase 7


value: Uncharacterized protein

value: Cilium axoneme

value: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating

value: C:ciliary basal body


value: C:cell projection


value: Endosome membrane

value: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic

value: C:cellular anatomical structure


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein


value: TatD DNase domain containing 1

value: substring

value: TatD DNase domain-containing protein


value: KHDRBS Qua1

value: KHDRBS Qua1 domain-containing protein

value: F:RNA binding

value: KH RNA binding domain containing, signal transduction associated 3

value: hydrated


value: Amino acid transporter transmembrane

value: Amino acid transporter transmembrane domain-containing protein


value: Importin N-terminal

value: Importin N-terminal domain-containing protein


value: Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein

value: GO


value: Uncharacterized protein

value: Mitochondrion matrix


value: Centriolar satellite

value: Cytoskeleton

value: Microtubule organizing center

value: Centrosome


value: PANTHER

value: substring

value: Palmitoyltransferase ZDHHC24

value: Palmitoyltransferase specific for casein kinase 1


value: domain

value: G-protein coupled receptors family 1 profile domain-containing protein


value: Rho-related GTP-binding protein RhoD

value: Membrane


value: Transmembrane protein 25


value: Olfactory receptor 10J5

value: Putative odorant or sperm cell receptor


value: InterPro

value: hydrated

value: Histidine kinase/HSP90-like ATPase domain-containing protein

value: Molecular chaperone. Has ATPase activity


value: Rab-GAP TBC

value: Rab-GAP TBC domain-containing protein

value: P:activation of GTPase activity

value: F:GTPase activator activity


value: PANTHER

value: Prefoldin subunit 5

value: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins


value: Ras-related protein Rab-25


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein

value: Nucleus


value: Roundabout homolog 2


value: RRM

value: RRM domain-containing protein


value: SPATA31 domain-containing protein


value: G-protein coupled receptors family 3 profile domain-containing protein

value: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity


value: BTB

value: BTB domain-containing protein


value: Unconventional myosin-Ib

value: GO

value: hydrated

value: Cell projection


value: PANTHER

value: Coiled-coil domain-containing protein 106


value: Belongs to the aldehyde dehydrogenase family.

value: Aldehyde dehydrogenase domain-containing protein

value: Mitochondrion matrix


value: NID

value: domain

value: NID domain-containing protein

value: C:extracellular region


value: Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein


value: Lipocalin/cytosolic fatty-acid binding

value: Lipocalin/cytosolic fatty-acid binding domain-containing protein


value: Ribosomal protein L23/L25 N-terminal

value: Ribosomal protein L23/L25 N-terminal domain-containing protein

value: Binds to 23S rRNA

value: keyword

value: Cytoplasm


value: Homeobox

value: Homeobox domain-containing protein

value: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis


value: ASD2 domain-containing protein

value: GO

value: hydrated


value: BHLH

value: domain

value: BHLH domain-containing protein


value: Dynamin N-terminal

value: Dynamin N-terminal domain-containing protein

value: Nucleus


value: PANTHER

value: substring

value: T-complex protein 11


value: Protein KIBRA

value: Apical cell membrane

value: C:cellular anatomical structure


value: C2H2-type domain-containing protein

value: May be involved in transcriptional regulation

value: P:regulation of DNA-templated transcription


value: Galactosyltransferase N-terminal

value: Galactosyltransferase N-terminal domain-containing protein

value: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids


value: domain

value: Thiamin pyrophosphokinase thiamin-binding domain-containing protein


value: F:DNA binding

value: F:metal ion binding

value: keyword

value: hydrated


value: PANTHER

value: High mobility group protein HMGI-C


value: PR domain zinc finger protein 15

value: Nucleus


value: OCA

value: OCA domain-containing protein


value: Uncharacterized protein

value: Mitochondrion


value: Apical cell membrane

value: Cell projection

value: F:oxidoreductase activity

value: GO


value: EF-hand

value: domain

value: EF-hand domain-containing protein

value: Endoplasmic reticulum lumen


value: BRCA1-associated ATM activator 1

value: Cytoplasm


value: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system


value: Leucine-rich repeat-containing protein 59

value: Endoplasmic reticulum membrane


value: SMART

value: PH domain-containing protein

value: Endomembrane system


value: InterPro

value: PDZ domain-containing protein

value: C:PAR polarity complex

value: C:plasma membrane

value: hydrated

value: C:bicellular tight junction


value: domain

value: INO80 complex subunit B-like conserved region domain-containing protein

value: Nucleus

value: Nucleolus


value: Uncharacterized protein

value: GO

value: keyword

value: C:exosome (RNase complex)


value: Membrane


value: Deacetylase sirtuin-type

value: Deacetylase sirtuin-type domain-containing protein

value: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo

value: Mitochondrion matrix

value: F:metal ion binding


value: Keratin, type I cytoskeletal 39

value: Axon

value: Cell projection

value: F:structural molecule activity


value: PANTHER

value: substring

value: Synapse differentiation-inducing gene protein 1


value: domain

value: Ancestral coatomer element 1 Sec16/Sec31 domain-containing protein


value: P2Y purinoceptor 4


value: Fatty acid hydroxylase

value: Fatty acid hydroxylase domain-containing protein

value: GO

value: Endoplasmic reticulum membrane

value: F:oxidoreductase activity

value: hydrated

value: P:lipid biosynthetic process


value: Uncharacterized protein

value: May be involved in transcriptional regulation

value: F:sequence-specific double-stranded DNA binding

value: P:DNA-templated transcription


value: SH3 domain-containing protein

value: Membrane

value: Cytoplasm

value: P:signal transduction


value: domain

value: C3H1-type domain-containing protein


value: Cytoskeleton

value: P:intracellular signal transduction


value: P:regulation of meiosis I

value: C:plasma membrane

value: GO

value: P:female pronucleus assembly

value: P:protein phosphorylation

value: P:positive regulation of phosphorylation

value: P:female meiotic nuclear division


value: Sulfatase N-terminal

value: Sulfatase N-terminal domain-containing protein

value: Lysosome


value: PANTHER

value: Formin-like protein

value: substring


value: Cadherin

value: domain

value: Cadherin domain-containing protein

value: hydrated


value: Fructose-bisphosphate aldolase C

value: Cytoplasm


value: Uncharacterized protein

DNA damage

value: GO

value: Nucleus


value: Lysosome-associated membrane glycoprotein 3


value: NR LBD

value: NR LBD domain-containing protein


value: Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein


value: Membrane


value: Cytoskeleton

value: P:cilium assembly


value: PROSITE

value: RRM domain-containing protein

value: C:spliceosomal complex


value: C:extracellular region


value: InterPro

value: Ig-like domain-containing protein


value: domain

value: G protein-regulated inducer of neurite outgrowth C-terminal domain-containing protein


value: Pfam

value: F-box domain-containing protein


value: IF rod

value: IF rod domain-containing protein


value: PANTHER

value: Leucine-rich repeat-containing protein 18

value: GO

value: Cytoplasm


value: Coiled-coil domain-containing protein 63

value: hydrated

value: Cilium axoneme

value: Cytoskeleton

value: P:spermatid development


value: PROSITE

value: SEA domain-containing protein


value: Calponin-homology (CH)

value: domain

value: Calponin-homology (CH) domain-containing protein


value: Uncharacterized protein

value: Nucleus


value: P:cell communication


value: Peptidase S1

value: Peptidase S1 domain-containing protein

value: Secreted


value: Phospholipid/glycerol acyltransferase

value: Phospholipid/glycerol acyltransferase domain-containing protein

value: GO

value: Membrane


value: N-terminal acetyltransferase B complex subunit MDM20 homolog

value: Cytoplasm

value: Cytosol


value: glutathione transferase


value: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin

value: Mitochondrion matrix


value: SMB

value: domain

value: SMB domain-containing protein


value: Uncharacterized protein

value: F:kinase activity

value: hydrated


value: P:positive regulation of apoptotic process

value: P:apoptotic process


value: SURP motif

value: SURP motif domain-containing protein

value: Nucleus


value: PANTHER


value: substring

value: Phosphodiesterase 4D


value: GO


value: Serpin

value: Serpin domain-containing protein

value: Secreted


value: InterPro

value: CCR4-NOT transcription complex subunit 7

value: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression

value: C:CCR4-NOT complex

value: P:mRNA catabolic process


value: Uncharacterized protein

value: P:positive regulation of T cell cytokine production

value: F:CD40 receptor binding

value: C:ubiquitin ligase complex

value: C:tumor necrosis factor receptor superfamily complex

value: P:regulation of immunoglobulin production


value: VPS53 protein


value: keyword

value: Membrane


value: RING-type

value: domain

value: RING-type domain-containing protein

value: GO

value: hydrated


value: SMART

value: LRRCT domain-containing protein


value: MACPF

value: MACPF domain-containing protein

value: Secreted


value: BHLH

value: BHLH domain-containing protein


value: Fibronectin type-III

value: Fibronectin type-III domain-containing protein

value: Target cell membrane

value: P:locomotor rhythm

value: P:behavioral fear response


value: InterPro

value: tRNA-specific 2-thiouridylase MnmA

value: Mitochondrion


value: Uncharacterized protein

value: GO

value: F:transmembrane transporter activity


value: F-box

value: domain

value: F-box domain-containing protein

value: Nucleus


value: SAM domain-containing protein

value: Secreted


value: Neuronal acetylcholine receptor subunit alpha-5

value: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane


value: PROSITE

value: HP domain-containing protein

value: substring

value: Cytoskeleton

value: Cytoplasm

value: P:cytoskeleton organization

value: keyword

value: hydrated

value: P:actin filament capping


value: PANTHER

value: Nodal modulator 1


value: Placenta-specific gene 8 protein

value: P:negative regulation of apoptotic process

value: P:positive regulation of cell population proliferation

value: P:transcription by RNA polymerase II

value: GO

value: P:defense response to bacterium

value: P:negative regulation of multicellular organism growth

value: P:response to cold

value: F:chromatin binding


value: InterPro

value: Death domain-containing protein

value: Target cell membrane

value: Secreted


value: substring

value: Cytochrome b5 reductase 2

value: Mitochondrion outer membrane

value: Endoplasmic reticulum membrane


value: Uncharacterized protein

value: Nucleus


value: Ras-specific guanine nucleotide-releasing factor 1

value: P:Ras protein signal transduction

value: P:blood vessel development

value: P:positive regulation of GTPase activity


value: PANTHER

value: HAUS augmin-like complex subunit 4


value: domain

value: Opioid growth factor receptor (OGFr) conserved domain-containing protein


value: C:extracellular region


value: CoA carboxyltransferase C-terminal

value: CoA carboxyltransferase C-terminal domain-containing protein


value: Obg

value: Obg domain-containing protein

value: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control

value: F:GTP binding

value: GTP binding protein 10

value: hydrated

value: F:GTPase activity


value: UBC core

value: UBC core domain-containing protein

value: Nucleus

value: P:protein ubiquitination


value: Neurexin/syndecan/glycophorin C

value: Neurexin/syndecan/glycophorin C domain-containing protein


value: GYF

value: domain

value: GYF domain-containing protein

value: C:Golgi apparatus

value: P:feeding behavior

value: P:post-embryonic development

value: P:post-transcriptional gene silencing

value: P:spinal cord motor neuron differentiation

value: C:endoplasmic reticulum

value: P:mitotic G1 DNA damage checkpoint signaling

value: C:protein-containing complex

value: P:adult locomotory behavior


value: Uncharacterized protein


value: C1q domain-containing protein


value: PANTHER

value: Inhibitor of nuclear factor kappa-B kinase subunit beta


value: Tetratricopeptide repeat protein 39C

value: Cytoskeleton

value: P:cholesterol homeostasis

value: P:regulation of cholesterol metabolic process

value: P:negative regulation of cholesterol storage

value: P:regulation of cholesterol efflux


value: Cell division control protein 42 homolog

value: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins

value: GO

value: Membrane


value: Protein kinase

value: domain

value: Protein kinase domain-containing protein


value: KASH

value: KASH domain-containing protein

value: Cytoplasmic

value: substring

value: Cytoplasm


value: WNT1-inducible-signaling pathway protein 2


value: PANTHER

Signal

value: keyword

value: hydrated

value: C:Golgi apparatus


value: C-type lectin

value: C-type lectin domain-containing protein


value: Uncharacterized protein

value: Membrane spanning 4-domains A4A


value: P-type ATPase N-terminal

value: P-type ATPase N-terminal domain-containing protein


value: Nucleus


value: Rap guanine nucleotide exchange factor 3


value: BZIP

value: domain

value: BZIP domain-containing protein


value: MOK protein kinase

value: substring

value: Protein kinase domain-containing protein

value: Cell projection


value: Chromo

value: Chromo domain-containing protein


value: CLN6 transmembrane ER protein

value: Membrane


value: GH18 domain-containing protein

value: Secreted


value: Uncharacterized protein

value: GO

value: hydrated

value: F:metal ion transmembrane transporter activity


value: G-protein coupled receptors family 1 profile domain-containing protein


value: Interferon-induced GTP-binding protein Mx

value: Cytoplasm


value: Mannose-P-dolichol utilization defect 1

value: Mannose-P-dolichol utilization defect 1 protein

value: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors


value: Nucleus

value: F:DNA binding


value: KRAB

value: domain

value: KRAB domain-containing protein

value: May be involved in transcriptional regulation


value: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins

value: F:4 iron, 4 sulfur cluster binding


value: Uncharacterized protein

value: C:TRAPPIII protein complex


value: RING-type

value: RING-type domain-containing protein


value: VWFA

value: VWFA domain-containing protein


value: GRAM

value: GRAM domain-containing protein

value: GO

value: hydrated

value: Cytoplasm


value: KRAB

value: Nucleus


value: Thioredoxin

value: domain

value: Thioredoxin domain-containing protein

value: Mitochondrion matrix

value: F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor


value: PANTHER

value: substring

value: DAN domain-containing protein

value: Secreted

value: C:extracellular region


value: Disks large homolog 5 N-terminal

value: Disks large homolog 5 N-terminal domain-containing protein


value: Nucleoporin NSP1-like C-terminal

value: Nucleoporin NSP1-like C-terminal domain-containing protein


value: Uncharacterized protein

value: ER membrane protein complex subunit 10

value: Membrane


value: PH

value: PH domain-containing protein


value: Nuclear receptor subfamily 2 group E member 1

value: F:sequence-specific DNA binding

value: GO

value: hydrated

value: F:DNA-binding transcription factor activity


value: Actin-like protein 10

value: Cytoskeleton

value: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

value: P:telomere maintenance


value: Nucleus

value: Cytoplasm


value: Putative odorant or sperm cell receptor


value: Uncharacterized protein

value: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

value: P:glycosaminoglycan metabolic process


value: Peptidase S1

value: domain

value: Peptidase S1 domain-containing protein

value: Secreted


value: GO


value: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity

value: hydrated


value: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

value: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation


value: Homeobox

value: Homeobox domain-containing protein


value: TEA

value: TEA domain-containing protein

value: F:DNA-binding transcription factor activity

value: F:DNA binding


value: Mammalian defensins

value: Mammalian defensins domain-containing protein

value: C:extracellular region


value: domain

value: STAT transcription factor protein interaction domain-containing protein


value: Uncharacterized protein

value: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.

value: substring

value: Putative pheromone receptor


value: PANTHER

value: RNA-binding protein FUS


value: BTB

value: BTB domain-containing protein

value: May be involved in transcriptional regulation


value: C2H2 AKAP95-type

value: C2H2 AKAP95-type domain-containing protein


value: MAGE

value: MAGE domain-containing protein


value: Chondroitin polymerizing factor 2


value: C-type lectin domain containing 7A

value: C-type lectin domain-containing protein

value: keyword

value: Membrane


value: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

value: Catalyzes the synthesis of activated sulfate


value: SSD

value: domain

value: SSD domain-containing protein


value: KRAB-related

value: KRAB-related domain-containing protein

value: GO

value: Nucleus


value: Uncharacterized protein

value: Putative odorant or sperm cell receptor


value: G-protein coupled receptors family 1 profile domain-containing protein


value: Olfactory receptor 2L13


value: SAM

value: SAM domain-containing protein

value: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation


value: Homeobox

value: Homeobox domain-containing protein

value: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

value: F:DNA-binding transcription factor activity, RNA polymerase II-specific

value: hydrated

value: F:DNA binding


value: PANTHER

value: Ankyrin repeat family A protein 2

value: Target cell membrane


value: InterPro

value: Keratin-associated protein

value: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa)


value: Olfactory receptor 6M1

value: Putative odorant or sperm cell receptor


value: Olfactory receptor 1F1


value: SMB

value: domain

value: SMB domain-containing protein

value: Secreted

Hydrolase

value: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.


value: N-terminal Ras-GEF

value: N-terminal Ras-GEF domain-containing protein

value: Nucleus


value: Uncharacterized protein

value: Prolactin acts primarily on the mammary gland by promoting lactation

Signal

value: GO

value: hydrated


value: MSP

value: MSP domain-containing protein

value: Cytoplasm

value: P:positive regulation of neutrophil chemotaxis

value: P:positive regulation of monocyte chemotaxis


value: CCDC144C-like coiled-coil

value: CCDC144C-like coiled-coil domain-containing protein

value: Target cell membrane


value: Leucine-rich repeat-containing protein 1

value: P:response to other organism

value: P:defense response


value: stearoyl-CoA 9-desaturase

value: P:fatty acid biosynthetic process

value: F:metal ion binding