source:
  method: PMID:32470107 (Wei et al. 2020), rerun on current GOA
  generated_by: projects/RAR_MISANNOTATION/scripts/rar_rerun.py
  run_date: '2026-11-11'
  counting: direct
  threshold: 0.1
  go_version: releases/2026-07-26
  goa_files:
    25.H_sapiens.goa:
      date_generated: '2026-11-04'
      sha256: e25d582600f1be15ef37815fc08dad2df4deff82aad642f17f9a518e323881a3
    59.M_musculus.goa:
      date_generated: '2026-11-04'
      sha256: c63a4e0cd7c88ed3267dbd64d0bcde2c31ae3742a3c42dd677af5a8895615ae8
    4825697.G_gallus_2.goa:
      date_generated: '2026-11-04'
      sha256: cf99680fce6d6f020292bac7b75e3fb1205e8a01d12414400a7fe82e1b0d31fa
    17.D_melanogaster.goa:
      date_generated: '2026-11-04'
      sha256: 889787066d7540e3df9702dae4b760d14b82e6b961ae095acd410ea815949a84
    9.C_elegans.goa:
      date_generated: '2026-11-04'
      sha256: fb65537b940b08638d248553b51da88954a10da3db29a422289c2c51323d3931
    18.E_coli_MG1655.goa:
      date_generated: '2026-11-04'
      sha256: 6ee7159cdf225cb0838e8d483c39d5d1b528628a39beba4712a216ef1aa8909a
    25374.C_difficile_630.goa:
      date_generated: '2026-11-04'
      sha256: 05cc0d2129872bee88cd207b09d68af177a9e96013fd2ce9737ef27ebb98ac5f
    6.B_subtilis_168.goa:
      date_generated: '2026-11-04'
      sha256: 7371fd18839cd46562685489ef4f9f1781fcb7b997dd356b1beffcb8cfa8330f
    23.H_pylori_26695.goa:
      date_generated: '2026-11-04'
      sha256: 96ec7698df251f7f2443c458b393e03ffa0cc97092c4a0cdaed6de1c955446fa
    31.M_genitalium.goa:
      date_generated: '2026-11-04'
      sha256: 9e49daad9fcb867753dfbc8017d792d1b158ef75cc5d2e69b5f5f01727d7ccc2
    25692.P_aeruginosa_UCBPP-PA14.goa:
      date_generated: '2026-11-04'
      sha256: 377218913827b7a206f1c7cbf89f29c93af7e6d3357d5eec1550c28e96bafab4
    69.S_typhimurium_ATCC_700720.goa:
      date_generated: '2026-11-04'
      sha256: c4fac4cafe3569af75bd9a131b660cd6a4bbbdddc7cdbabfab6d959cb645797f
    942.M_maripaludis_S2.goa:
      date_generated: '2026-11-04'
      sha256: eff1a64bb1aca3fee009faa3e1b1921b20c3dc058e0378ce1d5207edb07c8bb2
    21860.S_acidocaldarius.goa:
      date_generated: '2026-11-04'
      sha256: 63563a64b8645fc4dbcf4bef428072ff4b442fb5d1cde1e2390d37228555803b
    42.T_acidophilum.goa:
      date_generated: '2026-11-04'
      sha256: f10f8c780df7b7f6d9b629dc7fdb967491c03d84ea15bd867b8e8a370ebb3513
    71242.S_cerevisiae_ATCC_204508.goa:
      date_generated: '2026-11-04'
      sha256: 89028419e9928ec5bcc8fb5168393282e6a7f71fec634f1aadee1ddcff08908e
    78.S_pombe.goa:
      date_generated: '2026-11-04'
      sha256: 04928a4f5c2f9635dafad1ce4f3ffb3eb9913fbfdc64b656f8213c8682404d68
    22024.C_albicans_SC5314.goa:
      date_generated: '2026-11-04'
      sha256: 9f14e706e2466eee8d3c7aef8990286aa7e271a1a3454743a7f9564261be75fd
    217288.A_thaliana.goa:
      date_generated: '2026-11-04'
      sha256: 8e30c30e000b63d21871e1a00ed6e9db8321a74f571ee65cb00b6e9d764c1eb9
    34463.S_moellendorffii.goa:
      date_generated: '2026-11-04'
      sha256: 45cf2eb72b757556c11447ad52bc1d7e1af7389bd10f711c5f6b2a5a66e91c0f
  note: Flags are candidates for manual review, not confirmed errors.
  candidate_filter: q < 0.05, not a root term, at most 3 proteins in the flagged taxon; the unfiltered
    output is written to .cache/rar/rar_rerun_direct_full.yaml
kingdom:
  level: kingdom
  groups:
  - Animals
  - Archaea
  - Bacteria
  - Fungi
  - Plants
  annotated_proteins_per_group:
    Animals: 351036
    Archaea: 3544
    Bacteria: 19264
    Fungi: 17148
    Plants: 62066
  terms_with_rate_ratio: 8520
  flagged_terms: 2862
  terms:
  - go_id: GO:0000160
    label: phosphorelay signal transduction system
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 6
      Bacteria: 468
      Fungi: 22
      Plants: 157
    rate_ratio: 0.000117
    p_value: 0.0
    q_value: 0.0
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6TM12
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0000155
  - go_id: GO:0000155
    label: phosphorelay sensor kinase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 3
      Bacteria: 215
      Fungi: 7
      Plants: 61
    rate_ratio: 0.000255
    p_value: 3.92e-274
    q_value: 1.59e-271
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6TM12
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003661
  - go_id: GO:0043332
    label: mating projection tip
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 180
      Plants: 0
    rate_ratio: 0.000271
    p_value: 6.38e-238
    q_value: 1.94e-235
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9PDE7
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN004550576|SGD:S000003944
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0043332
  - go_id: GO:0044732
    label: mitotic spindle pole body
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 173
      Plants: 0
    rate_ratio: 0.000282
    p_value: 1.29e-228
    q_value: 3.44e-226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P07911
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20172860
      assigned_by: MGI
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:4751 (Fungi), on GO:0044732
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:4751 (Fungi), on GO:0044732
  - go_id: GO:2000142
    label: regulation of DNA-templated transcription initiation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 100
      Fungi: 0
      Plants: 13
    rate_ratio: 0.000549
    p_value: 7.97e-127
    q_value: 9.85e-125
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B2RS91
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:8413268
      assigned_by: MGI
  - go_id: GO:0051285
    label: cell cortex of cell tip
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 80
      Plants: 0
    rate_ratio: 0.000611
    p_value: 4.37e-105
    q_value: 4.24e-103
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EDS2
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:9130699
      assigned_by: WB
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0051285
  - go_id: GO:0016625
    label: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein
      as acceptor
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 16
      Bacteria: 11
      Fungi: 0
      Plants: 0
    rate_ratio: 0.000631
    p_value: 3.34e-31
    q_value: 6.83e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A494BB43
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR036021
  - go_id: GO:0110085
    label: mitotic actomyosin contractile ring
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 65
      Plants: 0
    rate_ratio: 0.000752
    p_value: 3.39e-85
    q_value: 2.58e-83
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VS45
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:36917931
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0110085
  - go_id: GO:0031097
    label: medial cortex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 47
      Plants: 0
    rate_ratio: 0.00104
    p_value: 2.32e-61
    q_value: 1.13e-59
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VZ85
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00049834
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031097
  - go_id: GO:0032993
    label: protein-DNA complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 288
      Archaea: 0
      Bacteria: 280
      Fungi: 4
      Plants: 1
    rate_ratio: 0.00111
    p_value: 3.1e-173
    q_value: 5.87e-171
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O24646
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17001643
      assigned_by: CAFA
      gene_review: genes/ARATH/HY5/HY5-ai-review.yaml
  - go_id: GO:0009734
    label: auxin-activated signaling pathway
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 136
    rate_ratio: 0.0013
    p_value: 2.58e-110
    q_value: 2.59e-108
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0ACI8SBU2
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR044991
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0009734
  - go_id: GO:0002229
    label: defense response to oomycetes
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 122
    rate_ratio: 0.00145
    p_value: 7.76e-99
    q_value: 6.89e-97
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08953
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:23865688
      assigned_by: FlyBase
      gene_review: genes/DROME/Tl/Tl-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0002229
  - go_id: GO:0051455
    label: spindle attachment to meiosis I kinetochore
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 28
      Plants: 2
    rate_ratio: 0.00174
    p_value: 2.83e-36
    q_value: 7.05e-35
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VUA5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:26668329
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051455
  - go_id: GO:0044550
    label: secondary metabolite biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 1
      Bacteria: 29
      Fungi: 3
      Plants: 0
    rate_ratio: 0.00189
    p_value: 3.35e-36
    q_value: 8.33e-35
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q95Q02
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002378821|PomBase:SPAC23G3.02c|UniProtKB:C8VPS9|UniProtKB:P11454|UniProtKB:P9WQ63|UniProtKB:Q4WAW3|UniProtKB:Q4WF53|UniProtKB:Q4WLW8|UniProtKB:Q4WMJ7|UniProtKB:Q4WR82|UniProtKB:Q4WYG2|UniProtKB:Q5BFS3|UniProtKB:Q9I181|UniProtKB:Q9I182
  - go_id: GO:0120105
    label: mitotic actomyosin contractile ring, intermediate layer
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 22
      Plants: 0
    rate_ratio: 0.00222
    p_value: 2.2e-28
    q_value: 3.94e-27
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9PDE7
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN004550576|PomBase:SPAC3G9.05
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0120105
  - go_id: GO:0005813
    label: centrosome
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 4975
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.00227
    p_value: 0.0
    q_value: 0.0
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RR71
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000471210|UniProtKB:Q8N954
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:33090 (Viridiplantae), on GO:0005813
    - protein: UniProtKB:Q9M2Q7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000471210|UniProtKB:Q8N954
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:33090 (Viridiplantae), on GO:0005813
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:27896 (Planariidae), on GO:0005813
    - never_in_taxon NCBITaxon:33090 (Viridiplantae), on GO:0005813
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0005813
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005813
  - go_id: GO:0043190
    label: ATP-binding cassette (ABC) transporter complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 44
      Archaea: 55
      Bacteria: 390
      Fungi: 3
      Plants: 3
    rate_ratio: 0.00239
    p_value: 1.01e-237
    q_value: 2.97e-235
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QQK4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR030802
    - protein: UniProtKB:D8R8C6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR030802
    - protein: UniProtKB:Q8L4R0
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR030802
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0043190
  - go_id: GO:0042907
    label: xanthine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 1
      Bacteria: 21
      Fungi: 2
      Plants: 1
    rate_ratio: 0.00261
    p_value: 4.59e-26
    q_value: 7.39e-25
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10090
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:117796
      assigned_by: UniProt
  - go_id: GO:0042906
    label: xanthine transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 1
      Bacteria: 21
      Fungi: 2
      Plants: 1
    rate_ratio: 0.00261
    p_value: 4.59e-26
    q_value: 7.39e-25
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10090
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:117796
      assigned_by: UniProt
  - go_id: GO:0071944
    label: cell periphery
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1277
      Archaea: 0
      Bacteria: 1
      Fungi: 331
      Plants: 52
    rate_ratio: 0.00269
    p_value: 1.99e-106
    q_value: 1.97e-104
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O30916
      taxon: NCBITaxon:99287
      evidence: IMP
      reference: PMID:21435037
      assigned_by: AgBase
  - go_id: GO:0044403
    label: biological process involved in symbiotic interaction
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 18
      Plants: 1
    rate_ratio: 0.00271
    p_value: 3.86e-23
    q_value: 5.31e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09958
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-9839923
      assigned_by: Reactome
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0044403
  - go_id: GO:0000001
    label: mitochondrion inheritance
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 36
      Plants: 1
    rate_ratio: 0.00271
    p_value: 1.45e-45
    q_value: 4.8e-44
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0KHV6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:30772175
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VAW5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:17951964
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000001
  - go_id: GO:0031126
    label: sno(s)RNA 3'-end processing
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 18
      Plants: 1
    rate_ratio: 0.00271
    p_value: 3.86e-23
    q_value: 5.31e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VRX7
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:29045842
      assigned_by: FlyBase
  - go_id: GO:0071466
    label: cellular response to xenobiotic stimulus
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 205
      Archaea: 0
      Bacteria: 1
      Fungi: 311
      Plants: 0
    rate_ratio: 0.00286
    p_value: 6.51e-100
    q_value: 5.9e-98
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P23895
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:24448799
      assigned_by: ComplexPortal
  - go_id: GO:0030907
    label: MBF transcription complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 17
      Plants: 0
    rate_ratio: 0.00287
    p_value: 7.86e-22
    q_value: 1.02e-20
    flagged_in_2019_or_2018: true
    flagged_annotations:
    - protein: UniProtKB:Q9N4L7
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000917496|PomBase:SPAC22F3.09c|PomBase:SPBC336.12c|PomBase:SPBC725.16|SGD:S000002214|SGD:S000004172
      gene_review: genes/worm/cec-10/cec-10-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0030907
  - go_id: GO:0030054
    label: cell junction
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1921
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00294
    p_value: 8.66e-134
    q_value: 1.15e-131
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LPJ1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19941015
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0030054
  - go_id: GO:0005351
    label: carbohydrate:proton symporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 1
      Bacteria: 32
      Fungi: 49
      Plants: 11
    rate_ratio: 0.00299
    p_value: 2.11e-61
    q_value: 1.04e-59
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O95528
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:11247674
      assigned_by: UniProt
    - protein: UniProtKB:Q9NRA2
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:10581036
      assigned_by: PINC
    - protein: UniProtKB:Q9NRM0
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:10860667
      assigned_by: UniProt
  - go_id: GO:0030874
    label: nucleolar chromatin
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 0
    rate_ratio: 0.00305
    p_value: 1.59e-20
    q_value: 1.93e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P30189
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:34544118
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0030874
  - go_id: GO:0034965
    label: intronic box C/D snoRNA processing
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 0
    rate_ratio: 0.00305
    p_value: 1.59e-20
    q_value: 1.93e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8SXD4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:41548216
      assigned_by: FlyBase
  - go_id: GO:0043065
    label: positive regulation of apoptotic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1834
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 1
    rate_ratio: 0.00308
    p_value: 1.17e-127
    q_value: 1.47e-125
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LSF1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:31123095
      assigned_by: TAIR
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0043065
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0043065
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0043065
  - go_id: GO:0005985
    label: sucrose metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 57
    rate_ratio: 0.0031
    p_value: 1.18e-45
    q_value: 3.98e-44
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10253
      taxon: NCBITaxon:9606
      evidence: IC
      reference: PMID:9505277
      assigned_by: BHF-UCL
      with_from: GO:0004558
      gene_review: genes/human/GAA/GAA-ai-review.yaml
  - go_id: GO:0140098
    label: catalytic activity, acting on RNA
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 1
      Bacteria: 34
      Fungi: 8
      Plants: 2
    rate_ratio: 0.00323
    p_value: 2.55e-41
    q_value: 7.45e-40
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E1JJR3
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027979
    - protein: UniProtKB:Q9VWI1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027979
  - go_id: GO:0015833
    label: peptide transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 53
      Archaea: 15
      Bacteria: 96
      Fungi: 4
      Plants: 1
    rate_ratio: 0.00323
    p_value: 1.33e-58
    q_value: 6.02e-57
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P46032
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:9232875
      assigned_by: TAIR
  - go_id: GO:0009751
    label: response to salicylic acid
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 158
    rate_ratio: 0.00336
    p_value: 7.22e-125
    q_value: 8.54e-123
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P58743
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9EPH0|ensembl:ENSRNOP00000015733
    - protein: UniProtKB:Q64471
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q01579|ensembl:ENSRNOP00000001669
    - protein: UniProtKB:Q99NH7
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9EPH0|ensembl:ENSRNOP00000015733
  - go_id: GO:0008792
    label: arginine decarboxylase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 3
      Bacteria: 11
      Fungi: 0
      Plants: 8
    rate_ratio: 0.00337
    p_value: 7.93e-06
    q_value: 2.71e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96A70
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-350598
      assigned_by: Reactome
      gene_review: genes/human/AZIN2/AZIN2-ai-review.yaml
  - go_id: GO:0035433
    label: acetate transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 3
      Bacteria: 2
      Fungi: 2
      Plants: 0
    rate_ratio: 0.00337
    p_value: 7.93e-06
    q_value: 2.71e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4LFF4
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:34107298
      assigned_by: FlyBase
  - go_id: GO:0004038
    label: allantoinase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 3
      Bacteria: 6
      Fungi: 2
      Plants: 4
    rate_ratio: 0.00337
    p_value: 7.93e-06
    q_value: 2.71e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VWW1
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G04955|PANTHER:PTN000909483|SGD:S000001466|UniProtKB:P77671|UniProtKB:Q5B4C7
    - protein: UniProtKB:Q9VWW1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017593
    - protein: UniProtKB:Q9VWW1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.2.5|EC:3.5.2.5
  - go_id: GO:0004451
    label: isocitrate lyase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 3
      Bacteria: 4
      Fungi: 3
      Plants: 4
    rate_ratio: 0.00337
    p_value: 7.93e-06
    q_value: 2.71e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G21720|CGD:CAL0000178151|PANTHER:PTN000493043|SGD:S000000867|UniProtKB:O07718|UniProtKB:P0A9G6|UniProtKB:P9WKK7|UniProtKB:Q6T267|UniProtKB:Q6Z6M4|UniProtKB:Q9I0K4
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR006254
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.1.3.1
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13245
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: PMID:11922622
      assigned_by: WB
  - go_id: GO:0061776
    label: ATP-dependent topological DNA co-entrapment activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 0
    rate_ratio: 0.00349
    p_value: 6.48e-18
    q_value: 6.6e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q23243
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:31442422
      assigned_by: UniProt
  - go_id: GO:0015802
    label: basic amino acid transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 7
    rate_ratio: 0.00376
    p_value: 1.3e-16
    q_value: 1.21e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q07837
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:8054986
      assigned_by: PINC
      gene_review: genes/human/SLC3A1/SLC3A1-ai-review.yaml
  - go_id: GO:0000500
    label: RNA polymerase I upstream activating factor complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 6
    rate_ratio: 0.00376
    p_value: 1.3e-16
    q_value: 1.21e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q22749
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00091673
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000500
  - go_id: GO:0030427
    label: site of polarized growth
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 17
      Archaea: 0
      Bacteria: 0
      Fungi: 72
      Plants: 1
    rate_ratio: 0.00384
    p_value: 1.62e-46
    q_value: 5.55e-45
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q38912
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:11387211
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030427
  - go_id: GO:0005983
    label: starch catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 46
    rate_ratio: 0.00384
    p_value: 1.09e-36
    q_value: 2.73e-35
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O43451
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9446624
      assigned_by: PINC
  - go_id: GO:0140727
    label: siRNA-mediated pericentric heterochromatin formation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 25
      Plants: 0
    rate_ratio: 0.00391
    p_value: 3.24e-31
    q_value: 6.63e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P45975
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19948966
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VUQ5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19948966
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4930 (Saccharomyces), on GO:0140727
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0140727
  - go_id: GO:0016530
    label: metallochaperone activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 13
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00422
    p_value: 5.45e-16
    q_value: 4.85e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O00244
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:15670166
      assigned_by: UniProt
  - go_id: GO:0019543
    label: propionate catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 4
      Bacteria: 26
      Fungi: 3
      Plants: 0
    rate_ratio: 0.00422
    p_value: 2.85e-31
    q_value: 5.87e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P41999
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:30625328
      assigned_by: UniProt
    - protein: UniProtKB:Q9XXM8
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:30625328
      assigned_by: UniProt
  - go_id: GO:0009625
    label: response to insect
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 82
    rate_ratio: 0.00431
    p_value: 1.59e-64
    q_value: 8.51e-63
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A6M3Q7I6
      taxon: NCBITaxon:7227
      evidence: IEP
      reference: PMID:33907186
      assigned_by: FlyBase
    - protein: UniProtKB:Q09024
      taxon: NCBITaxon:7227
      evidence: IEP
      reference: PMID:38566182
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0009625
  - go_id: GO:0010114
    label: response to red light
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 82
    rate_ratio: 0.00431
    p_value: 1.59e-64
    q_value: 8.51e-63
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P13360
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:14960620
      assigned_by: FlyBase
    - protein: UniProtKB:Q24106
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:14960620
      assigned_by: FlyBase
      gene_review: genes/DROME/hid/hid-ai-review.yaml
  - go_id: GO:0010124
    label: phenylacetate catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 7
      Bacteria: 23
      Fungi: 0
      Plants: 0
    rate_ratio: 0.00433
    p_value: 2.33e-12
    q_value: 1.62e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D6RJ12
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1302965
    - protein: UniProtKB:H3BL07
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1302965
    - protein: UniProtKB:Q62087
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1302965
  - go_id: GO:0052716
    label: hydroquinone:oxygen oxidoreductase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 40
    rate_ratio: 0.00442
    p_value: 8.26e-32
    q_value: 1.75e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z6F5
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.10.3.2
  - go_id: GO:0033215
    label: reductive iron assimilation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 1
      Fungi: 11
      Plants: 0
    rate_ratio: 0.00444
    p_value: 5.14e-14
    q_value: 3.98e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q53TN4
      taxon: NCBITaxon:9606
      evidence: IC
      reference: PMID:30272000
      assigned_by: UniProt
      with_from: GO:0140571
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0033215
  - go_id: GO:0015794
    label: glycerol-3-phosphate transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 12
      Fungi: 3
      Plants: 0
    rate_ratio: 0.00457
    p_value: 9.73e-15
    q_value: 7.99e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9WU81
      taxon: NCBITaxon:10090
      evidence: ISA
      reference: PMID:11112347
      assigned_by: MGI
      with_from: UniProtKB:P57057
  - go_id: GO:0043410
    label: positive regulation of MAPK cascade
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1235
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.00458
    p_value: 1.78e-85
    q_value: 1.37e-83
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q1PDV6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24750441
      assigned_by: GO_Central
      gene_review: genes/ARATH/PBL27/PBL27-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0043410
  - go_id: GO:0048731
    label: system development
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1061
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 744
    rate_ratio: 0.00486
    p_value: 4.84e-77
    q_value: 3.18e-75
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q59T43
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027702
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0048731
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0048731
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0048731
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0048731
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0048731
  - go_id: GO:0034044
    label: exomer complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 0
    rate_ratio: 0.00488
    p_value: 1.01e-12
    q_value: 7.27e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:H0Y6S0
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028457
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0034044
  - go_id: GO:1900239
    label: regulation of phenotypic switching
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 20
      Plants: 0
    rate_ratio: 0.00488
    p_value: 9.73e-25
    q_value: 1.45e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8IZQ8
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8VIM5|ensembl:ENSMUSP00000104335
    - protein: UniProtKB:Q8VIM5
      taxon: NCBITaxon:10090
      evidence: IGI
      reference: PMID:19578358
      assigned_by: BHF-UCL
      with_from: RNAcentral:URS0000527F89_10090
  - go_id: GO:0000772
    label: mating pheromone activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 0
    rate_ratio: 0.00488
    p_value: 1.01e-12
    q_value: 7.27e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5FW60
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:20525243
      assigned_by: MGI
    - protein: UniProtKB:Q5FW60
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:31996852
      assigned_by: UniProt
  - go_id: GO:0045033
    label: peroxisome inheritance
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 0
    rate_ratio: 0.00488
    p_value: 1.01e-12
    q_value: 7.27e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O44735
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024758
  - go_id: GO:0070161
    label: anchoring junction
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1149
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00492
    p_value: 1.99e-79
    q_value: 1.36e-77
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LPJ1
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:19941015
      assigned_by: UniProt
    - protein: UniProtKB:Q8LPJ1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0038
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0070161
  - go_id: GO:0043235
    label: signaling receptor complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1143
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00495
    p_value: 5.27e-79
    q_value: 3.56e-77
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SJV5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19207210
      assigned_by: TAIR
  - go_id: GO:0006097
    label: glyoxylate cycle
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 1
      Bacteria: 11
      Fungi: 8
      Plants: 7
    rate_ratio: 0.00499
    p_value: 1.73e-13
    q_value: 1.3e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000178151|PANTHER:PTN000493043|SGD:S000000867|UniProtKB:O07718|UniProtKB:P0A9G6|UniProtKB:P9WKK7
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR019830
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00703
    - protein: UniProtKB:Q10663
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: PMID:11922622
      assigned_by: WB
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:33511 (Deuterostomia), on GO:0006097
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0006097
    - never_in_taxon NCBITaxon:6656 (Arthropoda), on GO:0006097
  - go_id: GO:0031554
    label: regulation of termination of DNA-templated transcription
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 11
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00499
    p_value: 1.73e-13
    q_value: 1.3e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18409
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:18946043
      assigned_by: WB
      with_from: WB:WBGene00003004
  - go_id: GO:0016896
    label: RNA exonuclease activity, producing 5'-phosphomonoesters
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 2
      Bacteria: 8
      Fungi: 0
      Plants: 0
    rate_ratio: 0.00505
    p_value: 0.000595
    q_value: 0.00149
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8IU60
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-429860
      assigned_by: Reactome
  - go_id: GO:0008783
    label: agmatinase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 2
      Archaea: 4
      Bacteria: 9
      Fungi: 4
      Plants: 5
    rate_ratio: 0.00505
    p_value: 2.95e-07
    q_value: 1.23e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q90XD2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.3.11
    - protein: UniProtKB:Q90XD2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13929
    - protein: UniProtKB:Q90XD2
      taxon: NCBITaxon:9031
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9BSE5
    - protein: UniProtKB:Q9BSE5
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-350604
      assigned_by: Reactome
  - go_id: GO:0015123
    label: acetate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 2
      Bacteria: 5
      Fungi: 1
      Plants: 0
    rate_ratio: 0.00505
    p_value: 0.000595
    q_value: 0.00149
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4LFF4
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:34107298
      assigned_by: FlyBase
  - go_id: GO:0008477
    label: purine nucleosidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 1
      Archaea: 2
      Bacteria: 7
      Fungi: 5
      Plants: 3
    rate_ratio: 0.00505
    p_value: 0.000595
    q_value: 0.00149
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: EXP
      reference: PMID:12777783
      assigned_by: UniProt
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:28218438
      assigned_by: UniProt
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.2.2.1
  - go_id: GO:0061629
    label: RNA polymerase II-specific DNA-binding transcription factor binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1043
      Archaea: 0
      Bacteria: 0
      Fungi: 46
      Plants: 1
    rate_ratio: 0.00542
    p_value: 5.66e-72
    q_value: 3.45e-70
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O81834
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:30099385
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G11260
  - go_id: GO:0000404
    label: heteroduplex DNA loop binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 0
    rate_ratio: 0.00543
    p_value: 1.98e-11
    q_value: 1.26e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q01831
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:19941824
      assigned_by: UniProt
  - go_id: GO:0120029
    label: proton export across plasma membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 1
      Bacteria: 3
      Fungi: 9
      Plants: 25
    rate_ratio: 0.00543
    p_value: 1.98e-11
    q_value: 1.26e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q21461
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004712
  - go_id: GO:0017102
    label: methionyl glutamyl tRNA synthetase complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 3
    rate_ratio: 0.00543
    p_value: 1.98e-11
    q_value: 1.26e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q23315
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000012559|PomBase:SPAC17A5.15c|SGD:S000003214
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0017102
  - go_id: GO:0102039
    label: NADH-dependent peroxiredoxin activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 10
      Fungi: 0
      Plants: 0
    rate_ratio: 0.00549
    p_value: 3.04e-12
    q_value: 2.09e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P30048
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:7733872
      assigned_by: UniProt
  - go_id: GO:0008803
    label: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 10
      Fungi: 0
      Plants: 0
    rate_ratio: 0.00549
    p_value: 3.04e-12
    q_value: 2.09e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P50583
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:7487923
      assigned_by: PINC
      gene_review: genes/human/NUDT2/NUDT2-ai-review.yaml
  - go_id: GO:0043066
    label: negative regulation of apoptotic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 3091
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 3
    rate_ratio: 0.00549
    p_value: 9.45e-212
    q_value: 2.3e-209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SSK8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001580765|UniProtKB:Q9NX55
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0043066
    - protein: UniProtKB:Q9C901
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001580765|UniProtKB:Q9NX55
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0043066
    - protein: UniProtKB:Q9SNC6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22383540
      assigned_by: CACAO
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0043066
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0043066
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0043066
  - go_id: GO:0045017
    label: glycerolipid biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 32
    rate_ratio: 0.00553
    p_value: 2.56e-25
    q_value: 3.94e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VJ41
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045034
  - go_id: GO:0031408
    label: oxylipin biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 61
    rate_ratio: 0.0058
    p_value: 1.73e-47
    q_value: 6.08e-46
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q02928
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00382
    - protein: UniProtKB:Q9HBI6
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00382
  - go_id: GO:0031012
    label: extracellular matrix
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 3103
      Archaea: 0
      Bacteria: 1
      Fungi: 1
      Plants: 53
    rate_ratio: 0.00587
    p_value: 3.28e-70
    q_value: 1.9e-68
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q17ZZ0
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001813385
  - go_id: GO:0008017
    label: microtubule binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2812
      Archaea: 0
      Bacteria: 1
      Fungi: 98
      Plants: 532
    rate_ratio: 0.00606
    p_value: 8.91e-61
    q_value: 4.34e-59
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKN9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000436624
  - go_id: GO:0045936
    label: negative regulation of phosphate metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 5
      Bacteria: 5
      Fungi: 3
      Plants: 0
    rate_ratio: 0.00606
    p_value: 1.09e-08
    q_value: 5.33e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XX26
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028171
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028171
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028171
  - go_id: GO:1990837
    label: sequence-specific double-stranded DNA binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 3005
      Archaea: 0
      Bacteria: 1
      Fungi: 2
      Plants: 11
    rate_ratio: 0.00606
    p_value: 5.97e-68
    q_value: 3.39e-66
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P76057
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:26530864
      assigned_by: EcoCyc
  - go_id: GO:0004564
    label: beta-fructofuranosidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 3
      Plants: 29
    rate_ratio: 0.0061
    p_value: 6.87e-23
    q_value: 9.37e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B5THE3
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3675
  - go_id: GO:0035429
    label: gluconate transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 27
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0061
    p_value: 1.51e-31
    q_value: 3.15e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YGT0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8R2Z3|ensembl:ENSMUSP00000041789
    - protein: UniProtKB:Q8R2Z3
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:15591059
      assigned_by: UniProt
    - protein: UniProtKB:Q8TE54
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8R2Z3|ensembl:ENSMUSP00000041789
  - go_id: GO:0015169
    label: glycerol-3-phosphate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 9
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0061
    p_value: 5.32e-11
    q_value: 3.28e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9WU81
      taxon: NCBITaxon:10090
      evidence: ISA
      reference: PMID:11112347
      assigned_by: MGI
      with_from: UniProtKB:P57057
  - go_id: GO:0031942
    label: i-AAA complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 0
    rate_ratio: 0.00611
    p_value: 3.82e-10
    q_value: 2.19e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F3YDF1
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P32795
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0031942
  - go_id: GO:1901195
    label: positive regulation of formation of translation preinitiation complex
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 0
    rate_ratio: 0.00611
    p_value: 3.82e-10
    q_value: 2.19e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VGN7
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:29335528
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1901195
  - go_id: GO:0008515
    label: sucrose transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 28
    rate_ratio: 0.00631
    p_value: 4.42e-22
    q_value: 5.82e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VSV1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:21586609
      assigned_by: FlyBase
  - go_id: GO:0000171
    label: ribonuclease MRP activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 23
      Plants: 0
    rate_ratio: 0.00637
    p_value: 1.06e-27
    q_value: 1.82e-26
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O75818
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001034909|PomBase:SPAC6C3.09
    - protein: UniProtKB:Q8R1F9
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001034909|PomBase:SPAC6C3.09
    - protein: UniProtKB:Q9DB28
      taxon: NCBITaxon:10090
      evidence: ISA
      reference: PMID:11413139
      assigned_by: MGI
      with_from: UniProtKB:P28005
  - go_id: GO:0071042
    label: nuclear polyadenylation-dependent mRNA catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 23
      Plants: 0
    rate_ratio: 0.00637
    p_value: 1.06e-27
    q_value: 1.82e-26
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D5NZ09
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8TCS8|ensembl:ENSP00000400646
    - protein: UniProtKB:Q8K1R3
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8TCS8|ensembl:ENSP00000400646
    - protein: UniProtKB:Q8K1R3
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q8TCS8
    - protein: UniProtKB:Q8K1R3
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8TCS8
    - protein: UniProtKB:Q8TCS8
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:16934922
      assigned_by: UniProt
      gene_review: genes/human/PNPT1/PNPT1-ai-review.yaml
  - go_id: GO:0008658
    label: penicillin binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 48
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00647
    p_value: 7.12e-29
    q_value: 1.31e-27
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R6S4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001460
  - go_id: GO:0006566
    label: L-threonine metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 2
      Archaea: 3
      Bacteria: 16
      Fungi: 3
      Plants: 3
    rate_ratio: 0.00673
    p_value: 1.97e-05
    q_value: 6.34e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6ZSB7
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19114063
      assigned_by: MGI
      with_from: MGI:MGI:3769591
    - protein: UniProtKB:Q61753
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19114063
      assigned_by: MGI
      with_from: MGI:MGI:3769591
  - go_id: GO:0009693
    label: ethylene biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 26
    rate_ratio: 0.0068
    p_value: 1.82e-20
    q_value: 2.19e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XID9
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00091972
  - go_id: GO:0009863
    label: salicylic acid mediated signaling pathway
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 26
    rate_ratio: 0.0068
    p_value: 1.82e-20
    q_value: 2.19e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VR90
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084971
  - go_id: GO:0005125
    label: cytokine activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 828
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00683
    p_value: 7.16e-57
    q_value: 3.13e-55
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P33154
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:37542077
      assigned_by: TAIR
      gene_review: genes/ARATH/P33154/P33154-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0005125
  - go_id: GO:0005201
    label: extracellular matrix structural constituent
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 826
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00685
    p_value: 9.9e-57
    q_value: 4.26e-55
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94BT2
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:10080694
      assigned_by: TIGR
  - go_id: GO:1903806
    label: L-isoleucine import across plasma membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 8
      Fungi: 0
      Plants: 0
    rate_ratio: 0.00686
    p_value: 9.21e-10
    q_value: 5.1e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9NP91
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: PMID:16234310
      assigned_by: ARUK-UCL
      with_from: UniProtKB:F6SPX0
  - go_id: GO:0099617
    label: matrix side of mitochondrial inner membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 29
      Archaea: 0
      Bacteria: 0
      Fungi: 40
      Plants: 1
    rate_ratio: 0.00691
    p_value: 1.69e-25
    q_value: 2.62e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q1JPL4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16258072
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0099617
  - go_id: GO:1904679
    label: myo-inositol import across plasma membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 0
    rate_ratio: 0.00698
    p_value: 7.3e-09
    q_value: 3.64e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P53794
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q80WA5
  - go_id: GO:0044395
    label: protein targeting to vacuolar membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 0
    rate_ratio: 0.00698
    p_value: 7.3e-09
    q_value: 3.64e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A140LIF8
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:34078740
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0044395
  - go_id: GO:0097002
    label: mitochondrial inner boundary membrane
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 0
    rate_ratio: 0.00698
    p_value: 7.3e-09
    q_value: 3.64e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9Y171
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:31746672
      assigned_by: FlyBase
    - protein: UniProtKB:Q9Y171
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P39952
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0097002
  - go_id: GO:0045551
    label: cinnamyl-alcohol dehydrogenase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 25
    rate_ratio: 0.00707
    p_value: 1.17e-19
    q_value: 1.34e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O60218
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:10392
  - go_id: GO:0008092
    label: cytoskeletal protein binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 776
      Archaea: 0
      Bacteria: 2
      Fungi: 11
      Plants: 1
    rate_ratio: 0.00729
    p_value: 3.19e-53
    q_value: 1.28e-51
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZSY2
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:9927707
      assigned_by: TAIR
  - go_id: GO:0072686
    label: mitotic spindle
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 947
      Archaea: 0
      Bacteria: 1
      Fungi: 121
      Plants: 28
    rate_ratio: 0.00736
    p_value: 3.49e-38
    q_value: 9.19e-37
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q189D3
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000649234
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0072686
  - go_id: GO:0032541
    label: cortical endoplasmic reticulum
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 43
      Archaea: 0
      Bacteria: 0
      Fungi: 75
      Plants: 2
    rate_ratio: 0.00737
    p_value: 5.18e-47
    q_value: 1.79e-45
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22227
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22285304
      assigned_by: TAIR
    - protein: UniProtKB:Q9SKR2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25792253
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0032541
  - go_id: GO:0005987
    label: sucrose catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 2
      Fungi: 13
      Plants: 30
    rate_ratio: 0.00752
    p_value: 9.33e-16
    q_value: 8.15e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B5THE3
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:34914943
      assigned_by: UniProt
    - protein: UniProtKB:B5THE3
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P14410
    - protein: UniProtKB:P14410
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:27480812
      assigned_by: UniProt
  - go_id: GO:0070911
    label: global genome nucleotide-excision repair
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 0
    rate_ratio: 0.00752
    p_value: 9.33e-16
    q_value: 8.15e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6ZNA4
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-5696399
      assigned_by: Reactome
    - protein: UniProtKB:Q70EL2
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-5696399
      assigned_by: Reactome
  - go_id: GO:0031267
    label: small GTPase binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 2420
      Archaea: 1
      Bacteria: 1
      Fungi: 102
      Plants: 88
    rate_ratio: 0.00753
    p_value: 1.8e-54
    q_value: 7.41e-53
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FD10
      taxon: NCBITaxon:99287
      evidence: IPI
      reference: PMID:19887681
      assigned_by: AgBase
      with_from: UniProtKB:P61586
    - protein: UniProtKB:Q9FD10
      taxon: NCBITaxon:99287
      evidence: IPI
      reference: PMID:22740689
      assigned_by: AgBase
      with_from: UniProtKB:P61586
  - go_id: GO:0033553
    label: rDNA heterochromatin
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 0
      Fungi: 36
      Plants: 1
    rate_ratio: 0.00767
    p_value: 6.94e-23
    q_value: 9.44e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84JC0
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:O43159
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0033553
  - go_id: GO:0036218
    label: dTTP diphosphatase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 7
      Fungi: 3
      Plants: 0
    rate_ratio: 0.00784
    p_value: 1.57e-08
    q_value: 7.58e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O95671
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:24210219
      assigned_by: UniProt
    - protein: UniProtKB:O95671
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:28534
  - go_id: GO:0020002
    label: host cell plasma membrane
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 0
    rate_ratio: 0.00784
    p_value: 1.57e-08
    q_value: 7.58e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5T0T0
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:36867660
      assigned_by: UniProt
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0020002
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0020002
  - go_id: GO:0015774
    label: polysaccharide transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 3
    rate_ratio: 0.00784
    p_value: 1.57e-08
    q_value: 7.58e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9JJY3
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:22383528
      assigned_by: MGI
      with_from: MGI:MGI:1856877
  - go_id: GO:0019277
    label: UDP-N-acetylgalactosamine biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 2
    rate_ratio: 0.00784
    p_value: 1.57e-08
    q_value: 7.58e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W0P5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22654673
      assigned_by: FlyBase
  - go_id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2201
      Archaea: 0
      Bacteria: 2
      Fungi: 227
      Plants: 318
    rate_ratio: 0.00784
    p_value: 8.55e-71
    q_value: 4.99e-69
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O31912
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN007723485|UniProtKB:Q86XK2
    - protein: UniProtKB:P94409
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN007723485|UniProtKB:Q86XK2
  - go_id: GO:0046677
    label: response to antibiotic
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 97
      Archaea: 0
      Bacteria: 118
      Fungi: 1
      Plants: 3
    rate_ratio: 0.00789
    p_value: 4.0e-69
    q_value: 2.29e-67
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QZA1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007815
    - protein: UniProtKB:D8RWK2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007815
    - protein: UniProtKB:D8SMK5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007815
  - go_id: GO:0019164
    label: pyruvate synthase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 23
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.008
    p_value: 1.03e-17
    q_value: 1.04e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q183B6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.7.1|EC:1.2.7.1
    - protein: UniProtKB:Q183B6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12765
    - protein: UniProtKB:Q183B6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029036
  - go_id: GO:0005811
    label: lipid droplet
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1014
      Archaea: 0
      Bacteria: 1
      Fungi: 111
      Plants: 136
    rate_ratio: 0.00802
    p_value: 5.98e-35
    q_value: 1.43e-33
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q796C3
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018333
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005811
  - go_id: GO:0030496
    label: midbody
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1400
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 2
    rate_ratio: 0.00808
    p_value: 4.6e-95
    q_value: 3.96e-93
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T0K0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0469
    - protein: UniProtKB:D8TER3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0469
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030496
  - go_id: GO:0015926
    label: glucosidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 4
      Fungi: 12
      Plants: 1
    rate_ratio: 0.00814
    p_value: 1.74e-14
    q_value: 1.41e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q13724
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:7635146
      assigned_by: PINC
    - protein: UniProtKB:Q8BHN3
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: PMID:9148925
      assigned_by: MGI
      with_from: UniProtKB:Q14697
  - go_id: GO:0045903
    label: positive regulation of translational fidelity
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 2
      Fungi: 12
      Plants: 0
    rate_ratio: 0.00814
    p_value: 1.74e-14
    q_value: 1.41e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F7AVE4
      taxon: NCBITaxon:10090
      evidence: IGI
      reference: PMID:25738458
      assigned_by: MGI
      with_from: UniProtKB:P0AEI1
    - protein: UniProtKB:Q8BTW8
      taxon: NCBITaxon:10090
      evidence: IGI
      reference: PMID:25738458
      assigned_by: MGI
      with_from: UniProtKB:P0AEI1
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045903
  - go_id: GO:0090374
    label: oligopeptide export from mitochondrion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 1
      Fungi: 6
      Plants: 0
    rate_ratio: 0.00814
    p_value: 1.37e-07
    q_value: 5.99e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KW40
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P33310
  - go_id: GO:0001015
    label: snoRNA transcription by RNA polymerase II
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.00814
    p_value: 1.37e-07
    q_value: 5.99e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V629
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:28420675
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0001015
  - go_id: GO:0006451
    label: translational readthrough
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.00814
    p_value: 1.37e-07
    q_value: 5.99e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VSM8
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:18772345
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006451
  - go_id: GO:0046938
    label: phytochelatin biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 9
    rate_ratio: 0.00814
    p_value: 1.37e-07
    q_value: 5.99e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G03980|AGI_LocusCode:AT5G44070|PANTHER:PTN002124892|PomBase:SPAC3H1.10|WB:WBGene00003960
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:11313333
      assigned_by: WB
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007719|InterPro:IPR040409
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084495
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20221439
      assigned_by: WB
      with_from: WB:WBVar00250713
  - go_id: GO:0110044
    label: regulation of cell cycle switching, mitotic to meiotic cell cycle
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.00814
    p_value: 1.37e-07
    q_value: 5.99e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q17684
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20419786
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0110044
  - go_id: GO:0000406
    label: double-strand/single-strand DNA junction binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.00814
    p_value: 1.37e-07
    q_value: 5.99e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9TXR4
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: PMID:12072462
      assigned_by: WB
      with_from: UniProtKB:P25847
  - go_id: GO:0043200
    label: response to amino acid
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 73
      Archaea: 7
      Bacteria: 14
      Fungi: 4
      Plants: 1
    rate_ratio: 0.00816
    p_value: 2.05e-08
    q_value: 9.7e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O24495
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24760003
      assigned_by: TAIR
  - go_id: GO:0042826
    label: histone deacetylase binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 656
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.00862
    p_value: 8.25e-45
    q_value: 2.71e-43
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22130
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:22442143
      assigned_by: UniProt
      with_from: UniProtKB:O22446
    - protein: UniProtKB:O22130
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:22442143
      assigned_by: UniProt
      with_from: UniProtKB:Q8H0W2
    - protein: UniProtKB:O22130
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:22442143
      assigned_by: UniProt
      with_from: UniProtKB:Q9FML2
  - go_id: GO:0051701
    label: biological process involved in interaction with host
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 1
      Fungi: 32
      Plants: 1
    rate_ratio: 0.00863
    p_value: 2.82e-20
    q_value: 3.36e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0PCS3
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:22171001
      assigned_by: UniProt
      with_from: UniProtKB:P36279
    - protein: UniProtKB:Q0PCS3
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:22171001
      assigned_by: UniProt
      with_from: UniProtKB:Q9YPS2
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0051701
  - go_id: GO:0009645
    label: response to low light intensity stimulus
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 40
    rate_ratio: 0.00884
    p_value: 1.48e-30
    q_value: 2.9e-29
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15499
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P17438|ensembl:ENSRNOP00000095739
    - protein: UniProtKB:P23942
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P17438|ensembl:ENSRNOP00000095739
  - go_id: GO:0016854
    label: racemase and epimerase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 1
      Bacteria: 8
      Fungi: 4
      Plants: 40
    rate_ratio: 0.00884
    p_value: 1.48e-30
    q_value: 2.9e-29
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q17993
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000471580|UniProtKB:P26394|UniProtKB:P9WH11|UniProtKB:Q9HU21
    - protein: UniProtKB:Q9BPW9
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:11294878
      assigned_by: UniProt
  - go_id: GO:0010200
    label: response to chitin
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 20
    rate_ratio: 0.00884
    p_value: 1.24e-15
    q_value: 1.07e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A087WRT7
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:32589266
      assigned_by: MGI
  - go_id: GO:0000452
    label: snoRNA guided rRNA 2'-O-methylation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 0
    rate_ratio: 0.00888
    p_value: 3.2e-13
    q_value: 2.37e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VM69
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:22065625
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q9W1V3
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:22065625
      assigned_by: ComplexPortal
  - go_id: GO:0030036
    label: actin cytoskeleton organization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1870
      Archaea: 0
      Bacteria: 1
      Fungi: 100
      Plants: 88
    rate_ratio: 0.0089
    p_value: 2.14e-31
    q_value: 4.42e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7CQD4
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005414|InterPro:IPR016019
  - go_id: GO:0035264
    label: multicellular organism growth
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 622
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00909
    p_value: 1.98e-42
    q_value: 6.01e-41
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96289
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15333755
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0035264
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0035264
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0035264
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0035264
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0035264
  - go_id: GO:0000256
    label: allantoin catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 18
      Fungi: 14
      Plants: 9
    rate_ratio: 0.00915
    p_value: 1.78e-20
    q_value: 2.14e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8N6M5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005164|InterPro:IPR015908
      gene_review: genes/human/ALLC/ALLC-ai-review.yaml
    - protein: UniProtKB:Q9JHX6
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005164|InterPro:IPR015908
    - protein: UniProtKB:Q9VWW1
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000909483|SGD:S000001466
    - protein: UniProtKB:Q9VWW1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017593
    - protein: UniProtKB:Q9VWW1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00395
  - go_id: GO:0009036
    label: type II site-specific deoxyribonuclease activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 0
    rate_ratio: 0.00915
    p_value: 2.65e-07
    q_value: 1.11e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O00370
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:8945517
      assigned_by: UniProt
  - go_id: GO:0060567
    label: negative regulation of termination of DNA-templated transcription
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 6
      Fungi: 1
      Plants: 1
    rate_ratio: 0.00915
    p_value: 2.65e-07
    q_value: 1.11e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O54943
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:22767893
      assigned_by: UniProt
  - go_id: GO:0006849
    label: plasma membrane pyruvate transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 6
      Fungi: 1
      Plants: 1
    rate_ratio: 0.00915
    p_value: 2.65e-07
    q_value: 1.11e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4LFP5
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:30318245
      assigned_by: FlyBase
  - go_id: GO:0045437
    label: uridine nucleosidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 6
      Fungi: 5
      Plants: 4
    rate_ratio: 0.00915
    p_value: 2.65e-07
    q_value: 1.11e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: EXP
      reference: PMID:12777783
      assigned_by: UniProt
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.2.2.3
  - go_id: GO:0001100
    label: negative regulation of exit from mitosis
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 0
    rate_ratio: 0.00916
    p_value: 8.3e-19
    q_value: 8.93e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0X8M3
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9H4X1|ensembl:ENSP00000368664
    - protein: UniProtKB:Q9DBX1
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9H4X1|ensembl:ENSP00000368664
    - protein: UniProtKB:Q9DBX1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9H4X1
    - protein: UniProtKB:Q9H4X1
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:17146433
      assigned_by: BHF-UCL
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0001100
  - go_id: GO:0000709
    label: meiotic joint molecule formation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 3
    rate_ratio: 0.00916
    p_value: 8.3e-19
    q_value: 8.93e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZJB7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15
    - protein: UniProtKB:O35047
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15
    - protein: UniProtKB:Q9P2W1
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000709
  - go_id: GO:0006279
    label: premeiotic DNA replication
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 0
      Fungi: 30
      Plants: 1
    rate_ratio: 0.00921
    p_value: 5.66e-19
    q_value: 6.17e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LSG6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:14660803
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0006279
  - go_id: GO:0005085
    label: guanyl-nucleotide exchange factor activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 3934
      Archaea: 1
      Bacteria: 2
      Fungi: 149
      Plants: 141
    rate_ratio: 0.00926
    p_value: 2.24e-87
    q_value: 1.81e-85
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A6P1
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:11772013
      assigned_by: EcoCyc
    - protein: UniProtKB:Q7CQD4
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005414|InterPro:IPR016019
  - go_id: GO:0042593
    label: glucose homeostasis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 610
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.00927
    p_value: 1.37e-41
    q_value: 4.08e-40
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FRL3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21984725
      assigned_by: TAIR
  - go_id: GO:0007026
    label: negative regulation of microtubule depolymerization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 598
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.00946
    p_value: 9.49e-41
    q_value: 2.73e-39
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8RWY6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17873093
      assigned_by: UniProt
  - go_id: GO:0031508
    label: pericentric heterochromatin formation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 53
      Archaea: 0
      Bacteria: 0
      Fungi: 29
      Plants: 1
    rate_ratio: 0.00953
    p_value: 2.53e-18
    q_value: 2.64e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VYZ0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17242155
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031508
  - go_id: GO:0097038
    label: perinuclear endoplasmic reticulum
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 112
      Archaea: 0
      Bacteria: 0
      Fungi: 29
      Plants: 1
    rate_ratio: 0.00953
    p_value: 2.53e-18
    q_value: 2.64e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B3H4Y2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31001913
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0097038
  - go_id: GO:0048468
    label: cell development
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 586
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.00965
    p_value: 6.56e-40
    q_value: 1.82e-38
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J8V9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028665
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0048468
  - go_id: GO:0008933
    label: peptidoglycan lytic transglycosylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 32
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0097
    p_value: 4.9e-19
    q_value: 5.38e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SPF8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002410022|UniProtKB:P41052|UniProtKB:Q9HVX3|UniProtKB:Q9HX24|UniProtKB:Q9HX28
  - go_id: GO:2000639
    label: negative regulation of SREBP signaling pathway
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.00977
    p_value: 2.53e-06
    q_value: 9.3e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q969H0
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:Q0VGT7
      gene_review: genes/human/FBXW7/FBXW7-ai-review.yaml
  - go_id: GO:0006277
    label: DNA amplification
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.00977
    p_value: 2.53e-06
    q_value: 9.3e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O16810
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18711130
      assigned_by: FlyBase
  - go_id: GO:0043577
    label: chemotropism
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.00977
    p_value: 2.53e-06
    q_value: 9.3e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O76360
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:26434723
      assigned_by: UniProt
  - go_id: GO:0016156
    label: fumarate reductase (NADH) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.00977
    p_value: 2.53e-06
    q_value: 9.3e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09567
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN005162385|SGD:S000000773|SGD:S000003812|UniProtKB:Q57W38
    - protein: UniProtKB:Q09567
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.3.1.6|EC:1.3.1.6
  - go_id: GO:0090173
    label: regulation of synaptonemal complex assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 5
    rate_ratio: 0.00977
    p_value: 2.53e-06
    q_value: 9.3e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9N2V7
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20071466
      assigned_by: WB
      with_from: WB:WBVar00278479
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0090173
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0090173
  - go_id: GO:0045128
    label: negative regulation of reciprocal meiotic recombination
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 7
    rate_ratio: 0.00977
    p_value: 2.53e-06
    q_value: 9.3e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9U2M1
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:18198337
      assigned_by: WB
      with_from: WB:WBVar00241898|WB:WBVar00275343|WB:WBVar00275344|WB:WBVar00275349
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0045128
  - go_id: GO:0006890
    label: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 484
      Archaea: 0
      Bacteria: 1
      Fungi: 91
      Plants: 92
    rate_ratio: 0.00978
    p_value: 1.71e-28
    q_value: 3.07e-27
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18CX6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR006822
  - go_id: GO:0080146
    label: L-cysteine desulfhydrase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 1
      Bacteria: 11
      Fungi: 1
      Plants: 3
    rate_ratio: 0.00998
    p_value: 1.07e-12
    q_value: 7.64e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P32929
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24931
      gene_review: genes/human/CTH/CTH-ai-review.yaml
    - protein: UniProtKB:Q8VCN5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24931
  - go_id: GO:0071266
    label: '''de novo'' L-methionine biosynthetic process'
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 1
      Bacteria: 11
      Fungi: 9
      Plants: 2
    rate_ratio: 0.00998
    p_value: 1.07e-12
    q_value: 7.64e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O35490
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q93088
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:40674 (Mammalia), on GO:0071266
    - protein: UniProtKB:Q93088
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:10529246
      assigned_by: UniProt
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:40674 (Mammalia), on GO:0071266
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:40674 (Mammalia), on GO:0071266
  - go_id: GO:0004930
    label: G protein-coupled receptor activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 6110
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 21
    rate_ratio: 0.0101
    p_value: 2.15e-120
    q_value: 2.41e-118
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PN42
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2442046|PANTHER:PTN000560943|PomBase:SPCC1753.02c|SGD:S000002193|dictyBase:DDB_G0273397|dictyBase:DDB_G0277829
    - protein: UniProtKB:A0A1D8PN42
      taxon: NCBITaxon:237561
      evidence: ISS
      reference: PMID:12794933
      assigned_by: CGD
      with_from: SGD:S000002193
    - protein: UniProtKB:O94744
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2442046|PANTHER:PTN000560943|PomBase:SPCC1753.02c|SGD:S000002193|dictyBase:DDB_G0273397|dictyBase:DDB_G0277829
    - protein: UniProtKB:Q12361
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2442046|PANTHER:PTN000560943|PomBase:SPCC1753.02c|SGD:S000002193|dictyBase:DDB_G0273397|dictyBase:DDB_G0277829
    - protein: UniProtKB:Q12361
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:9524122
      assigned_by: SGD
    - protein: UniProtKB:Q12361
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:9388468
      assigned_by: SGD
      with_from: SGD:S000000822
    - protein: UniProtKB:Q12361
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:9524122
      assigned_by: SGD
      with_from: SGD:S000000822
  - go_id: GO:0043795
    label: glyceraldehyde oxidoreductase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 3
      Bacteria: 0
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0101
    p_value: 3.9e-05
    q_value: 0.000121
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D3YVJ7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P15121
    - protein: UniProtKB:P15121
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20837989
      assigned_by: UniProt
    - protein: UniProtKB:P45376
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P15121|ensembl:ENSP00000285930
    - protein: UniProtKB:P45376
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P15121
  - go_id: GO:0034213
    label: quinolinate catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 3
      Bacteria: 6
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0101
    p_value: 3.9e-05
    q_value: 0.000121
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0X6V9
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000789406|UniProtKB:Q15274
    - protein: UniProtKB:Q15274
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000789406|UniProtKB:Q15274
      gene_review: genes/human/QPRT/QPRT-ai-review.yaml
    - protein: UniProtKB:Q15274
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:24038671
      assigned_by: UniProt
      gene_review: genes/human/QPRT/QPRT-ai-review.yaml
    - protein: UniProtKB:Q15274
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:3409840
      assigned_by: UniProt
      gene_review: genes/human/QPRT/QPRT-ai-review.yaml
    - protein: UniProtKB:Q15274
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:9473669
      assigned_by: MGI
      gene_review: genes/human/QPRT/QPRT-ai-review.yaml
    - protein: UniProtKB:Q15274
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:9473669
      assigned_by: UniProt
      gene_review: genes/human/QPRT/QPRT-ai-review.yaml
    - protein: UniProtKB:Q91X91
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000789406|UniProtKB:Q15274
    - protein: UniProtKB:Q91X91
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000008
      assigned_by: MGI
      with_from: UniProtKB:Q15274
    - protein: UniProtKB:Q91X91
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q15274
  - go_id: GO:0072521
    label: purine-containing compound metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 3
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0101
    p_value: 3.9e-05
    q_value: 0.000121
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YG94
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026860
    - protein: UniProtKB:A0ACP0M6V1
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026860
    - protein: UniProtKB:Q20143
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026860
  - go_id: GO:0047934
    label: glucose 1-dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 2
      Archaea: 2
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0101
    p_value: 0.00118
    q_value: 0.00277
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O95479
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:14293
    - protein: UniProtKB:O95479
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8CFX1
    - protein: UniProtKB:Q8CFX1
      taxon: NCBITaxon:10090
      evidence: EXP
      reference: PMID:4169027
      assigned_by: UniProt
    - protein: UniProtKB:Q8CFX1
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:14293
  - go_id: GO:1903432
    label: regulation of TORC1 signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 53
      Archaea: 0
      Bacteria: 0
      Fungi: 27
      Plants: 1
    rate_ratio: 0.0102
    p_value: 5.04e-17
    q_value: 4.85e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q940X9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:33054972
      assigned_by: TAIR
  - go_id: GO:0031520
    label: plasma membrane of cell tip
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 27
      Plants: 1
    rate_ratio: 0.0102
    p_value: 5.04e-17
    q_value: 4.85e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C5G5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18281508
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031520
  - go_id: GO:0015450
    label: protein-transporting ATPase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 16
      Fungi: 2
      Plants: 17
    rate_ratio: 0.0103
    p_value: 4.8e-18
    q_value: 4.91e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D5RLZ6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q15388
    - protein: UniProtKB:Q19967
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: PMID:8707849
      assigned_by: WB
    - protein: UniProtKB:Q9DCC8
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q15388
  - go_id: GO:1904047
    label: S-adenosyl-L-methionine binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 156
      Archaea: 11
      Bacteria: 22
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0104
    p_value: 1.61e-12
    q_value: 1.14e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KFG1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000166007
    - protein: UniProtKB:F4KFG2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000166007
  - go_id: GO:0000407
    label: phagophore assembly site
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 474
      Archaea: 0
      Bacteria: 1
      Fungi: 85
      Plants: 39
    rate_ratio: 0.0105
    p_value: 1.47e-26
    q_value: 2.42e-25
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q185T5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN007795752
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0000407
  - go_id: GO:0009101
    label: glycoprotein biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1445
      Archaea: 5
      Bacteria: 2
      Fungi: 169
      Plants: 303
    rate_ratio: 0.0105
    p_value: 4.43e-52
    q_value: 1.74e-50
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O25142
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001503
    - protein: UniProtKB:O25366
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001503
  - go_id: GO:0045184
    label: establishment of protein localization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 519
      Archaea: 0
      Bacteria: 0
      Fungi: 17
      Plants: 1
    rate_ratio: 0.0109
    p_value: 3.18e-35
    q_value: 7.63e-34
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:C0LGQ5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25233277
      assigned_by: UniProt
  - go_id: GO:0015771
    label: trehalose transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 15
      Fungi: 3
      Plants: 0
    rate_ratio: 0.011
    p_value: 7.77e-17
    q_value: 7.37e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z8N1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:20035867
      assigned_by: FlyBase
      gene_review: genes/DROME/Tret1/Tret1-ai-review.yaml
    - protein: UniProtKB:A1Z8N1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:20035867
      assigned_by: UniProt
      gene_review: genes/DROME/Tret1/Tret1-ai-review.yaml
    - protein: UniProtKB:A1Z8N1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:34032568
      assigned_by: UniProt
      gene_review: genes/DROME/Tret1/Tret1-ai-review.yaml
    - protein: UniProtKB:Q8MLQ7
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:33551766
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VPX2
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015574
  - go_id: GO:0106415
    label: muramoyltetrapeptide carboxypeptidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 5
      Fungi: 0
      Plants: 0
    rate_ratio: 0.011
    p_value: 4.37e-06
    q_value: 1.55e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VYX7
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:15361936
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VYX7
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.4.17.13
    - protein: UniProtKB:Q9VYX7
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:48688
  - go_id: GO:0071474
    label: cellular hyperosmotic response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 60
      Archaea: 0
      Bacteria: 9
      Fungi: 25
      Plants: 1
    rate_ratio: 0.0111
    p_value: 1.0e-15
    q_value: 8.73e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XEA1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25162526
      assigned_by: UniProt
    - protein: UniProtKB:Q9XEA1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25162526
      assigned_by: TAIR
  - go_id: GO:0009254
    label: peptidoglycan turnover
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 55
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0113
    p_value: 7.44e-32
    q_value: 1.58e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RPD8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010611
    - protein: UniProtKB:D8SM46
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010611
  - go_id: GO:0006406
    label: mRNA export from nucleus
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 509
      Archaea: 0
      Bacteria: 1
      Fungi: 78
      Plants: 65
    rate_ratio: 0.0114
    p_value: 2.62e-24
    q_value: 3.82e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZC68
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001052033
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006406
  - go_id: GO:0001717
    label: conversion of seryl-tRNAsec to selenocys-tRNAsec
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 31
      Archaea: 5
      Bacteria: 15
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0114
    p_value: 5.27e-06
    q_value: 1.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8RWT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00906
  - go_id: GO:0015087
    label: cobalt ion transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 13
      Archaea: 5
      Bacteria: 19
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0114
    p_value: 5.27e-06
    q_value: 1.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KGN5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19861554
      assigned_by: TAIR
  - go_id: GO:0015753
    label: D-xylose transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0114
    p_value: 5.27e-06
    q_value: 1.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VZ80
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015148
  - go_id: GO:1903785
    label: L-valine transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 22
      Archaea: 1
      Bacteria: 27
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0115
    p_value: 5.58e-16
    q_value: 4.97e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84MA5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8618839
      assigned_by: UniProt
  - go_id: GO:0004622
    label: phosphatidylcholine lysophospholipase A1 activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 276
      Archaea: 0
      Bacteria: 10
      Fungi: 24
      Plants: 1
    rate_ratio: 0.0115
    p_value: 4.44e-15
    q_value: 3.74e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C942
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:20345607
      assigned_by: TAIR
  - go_id: GO:0045041
    label: protein import into mitochondrial intermembrane space
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 39
      Archaea: 0
      Bacteria: 0
      Fungi: 24
      Plants: 1
    rate_ratio: 0.0115
    p_value: 4.44e-15
    q_value: 3.74e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GYJ4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0260468|PANTHER:PTN000492699|SGD:S000001678|UniProtKB:Q8N4Q1
    - protein: UniProtKB:Q8GYJ4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039289
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045041
  - go_id: GO:1902533
    label: positive regulation of intracellular signal transduction
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 487
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0116
    p_value: 5.47e-33
    q_value: 1.23e-31
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7XJT7
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:19286558
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G63700
  - go_id: GO:0019992
    label: diacylglycerol binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1563
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 39
    rate_ratio: 0.0117
    p_value: 8.95e-35
    q_value: 2.13e-33
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P77211
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:21249122
      assigned_by: UniProt
  - go_id: GO:0009682
    label: induced systemic resistance
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 30
    rate_ratio: 0.0118
    p_value: 1.46e-22
    q_value: 1.95e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6SPW1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25084278
      assigned_by: MGI
      with_from: MGI:MGI:4421295
    - protein: UniProtKB:P22366
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25084278
      assigned_by: MGI
      with_from: MGI:MGI:4421295
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0009682
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0009682
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0009682
  - go_id: GO:0030695
    label: GTPase regulator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 242
      Archaea: 0
      Bacteria: 0
      Fungi: 23
      Plants: 1
    rate_ratio: 0.012
    p_value: 1.97e-14
    q_value: 1.58e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T2B9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN004747825|SGD:S000003132
  - go_id: GO:0075713
    label: establishment of integrated proviral latency
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 9
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0122
    p_value: 2.79e-10
    q_value: 1.62e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O54962
      taxon: NCBITaxon:10090
      evidence: TAS
      reference: PMID:11591818
      assigned_by: MGI
    - protein: UniProtKB:P49917
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-162592
      assigned_by: Reactome
      gene_review: genes/human/LIG4/LIG4-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0075713
  - go_id: GO:0044650
    label: adhesion of symbiont to host cell
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09529
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0046789
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0044650
  - go_id: GO:1903939
    label: regulation of TORC2 signaling
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 0
    rate_ratio: 0.0122
    p_value: 1.83e-09
    q_value: 9.8e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q86TY3
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8BT18
      gene_review: genes/human/ARMH4/ARMH4-ai-review.yaml
    - protein: UniProtKB:Q8BT18
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:25418727
      assigned_by: UniProt
  - go_id: GO:0046521
    label: sphingoid catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 4
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9NYA1
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:10863092
      assigned_by: UniProt
      gene_review: genes/human/SPHK1/SPHK1-ai-review.yaml
  - go_id: GO:0051601
    label: exocyst localization
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 0
    rate_ratio: 0.0122
    p_value: 1.83e-09
    q_value: 9.8e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z9X0
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:24607370
      assigned_by: FlyBase
    - protein: UniProtKB:P40793
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:24607370
      assigned_by: FlyBase
      gene_review: genes/DROME/Cdc42/Cdc42-ai-review.yaml
  - go_id: GO:0160247
    label: autophagy cargo adaptor activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P14199
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:25931115
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0160247
  - go_id: GO:0051237
    label: maintenance of RNA location
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P37276
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:16009136
      assigned_by: FlyBase
  - go_id: GO:0090153
    label: regulation of sphingolipid biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 5
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KUD4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:29909971
      assigned_by: FlyBase
  - go_id: GO:0071465
    label: cellular response to desiccation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8ITC7
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22253819
      assigned_by: FlyBase
  - go_id: GO:0061645
    label: endocytic patch
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V3I2
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:12876219
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0061645
  - go_id: GO:0072670
    label: mitochondrial tRNA threonylcarbamoyladenosine modification
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VWD6
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: PMID:25629598
      assigned_by: FlyBase
      with_from: UniProtKB:P43122
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0072670
  - go_id: GO:0010995
    label: free ubiquitin chain depolymerization
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0122
    p_value: 4.53e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VZU7
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:25152394
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0010995
  - go_id: GO:0061804
    label: mitotic spindle formation (spindle phase one)
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 0
    rate_ratio: 0.0122
    p_value: 1.83e-09
    q_value: 9.8e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5ECF4
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00090575
    - protein: UniProtKB:G5EGL7
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00090575
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0061804
  - go_id: GO:0016579
    label: protein deubiquitination
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1488
      Archaea: 0
      Bacteria: 1
      Fungi: 54
      Plants: 140
    rate_ratio: 0.0122
    p_value: 4.69e-33
    q_value: 1.06e-31
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q47013
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:17440617
      assigned_by: EcoCyc
  - go_id: GO:1990228
    label: sulfurtransferase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 25
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0124
    p_value: 9.25e-15
    q_value: 7.61e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FXE3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000978101|UniProtKB:P76194
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1990228
  - go_id: GO:0120025
    label: plasma membrane bounded cell projection
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 455
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0124
    p_value: 9.36e-31
    q_value: 1.86e-29
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RA45
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028036
  - go_id: GO:0008104
    label: intracellular protein localization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1379
      Archaea: 0
      Bacteria: 1
      Fungi: 71
      Plants: 48
    rate_ratio: 0.0125
    p_value: 4.66e-22
    q_value: 6.09e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AG86
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:6403503
      assigned_by: EcoCyc
      gene_review: genes/ECOLI/SecB/SecB-ai-review.yaml
  - go_id: GO:0017056
    label: structural constituent of nuclear pore
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 353
      Archaea: 0
      Bacteria: 1
      Fungi: 71
      Plants: 46
    rate_ratio: 0.0125
    p_value: 4.66e-22
    q_value: 6.09e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZC68
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001052033
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0017056
  - go_id: GO:0006952
    label: defense response
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 764
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 766
    rate_ratio: 0.0126
    p_value: 2.41e-84
    q_value: 1.8e-82
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P23827
      taxon: NCBITaxon:83333
      evidence: IC
      reference: PMID:20558234
      assigned_by: EcoCyc
    - protein: UniProtKB:P76002
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:20734102
      assigned_by: EcoCyc
    - protein: UniProtKB:P76578
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:26100869
      assigned_by: EcoCyc
  - go_id: GO:0022611
    label: dormancy process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 13
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0127
    p_value: 1.97e-14
    q_value: 1.58e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P13508
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00091893
      gene_review: genes/worm/glp-1/glp-1-ai-review.yaml
    - protein: UniProtKB:P14585
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00091893
      gene_review: genes/worm/lin-12/lin-12-ai-review.yaml
    - protein: UniProtKB:Q01617
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18852464
      assigned_by: FlyBase
  - go_id: GO:0000182
    label: rDNA binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 32
      Archaea: 0
      Bacteria: 0
      Fungi: 21
      Plants: 1
    rate_ratio: 0.0132
    p_value: 3.86e-13
    q_value: 2.85e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O23215
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18668124
      assigned_by: TAIR
  - go_id: GO:0072666
    label: establishment of protein localization to vacuole
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 0
    rate_ratio: 0.0133
    p_value: 1.43e-12
    q_value: 1.01e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D3YXE1
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:18952128
      assigned_by: MGI
    - protein: UniProtKB:D3Z5R6
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:18952128
      assigned_by: MGI
    - protein: UniProtKB:Q60769
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:18952128
      assigned_by: MGI
  - go_id: GO:0019901
    label: protein kinase binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 2718
      Archaea: 0
      Bacteria: 2
      Fungi: 67
      Plants: 68
    rate_ratio: 0.0134
    p_value: 1.75e-59
    q_value: 8.21e-58
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P42615
      taxon: NCBITaxon:83333
      evidence: EXP
      reference: PMID:19432797
      assigned_by: EcoCyc
    - protein: UniProtKB:P42615
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000067674
    - protein: UniProtKB:Q7CPR5
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000067674
  - go_id: GO:0009691
    label: cytokinin biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 2
      Fungi: 2
      Plants: 39
    rate_ratio: 0.0136
    p_value: 1.12e-28
    q_value: 2.04e-27
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E9Q8L0
      taxon: NCBITaxon:10090
      evidence: TAS
      reference: PMID:11805154
      assigned_by: MGI
    - protein: UniProtKB:F6X5B3
      taxon: NCBITaxon:10090
      evidence: TAS
      reference: PMID:11805154
      assigned_by: MGI
    - protein: UniProtKB:S4R2S1
      taxon: NCBITaxon:10090
      evidence: TAS
      reference: PMID:11805154
      assigned_by: MGI
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0009691
  - go_id: GO:1901962
    label: S-adenosyl-L-methionine transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 13
    rate_ratio: 0.0136
    p_value: 4.79e-10
    q_value: 2.71e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VBN7
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0000095
  - go_id: GO:0005096
    label: GTPase activator activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 4000
      Archaea: 0
      Bacteria: 3
      Fungi: 142
      Plants: 160
    rate_ratio: 0.0137
    p_value: 4.74e-87
    q_value: 3.78e-85
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZK02
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003537
    - protein: UniProtKB:P0A2N8
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007336
    - protein: UniProtKB:P0A8H6
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:20434458
      assigned_by: EcoCyc
    - protein: UniProtKB:P0A8H6
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007336
  - go_id: GO:0019605
    label: butyrate metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0137
    p_value: 7.02e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q08AH1
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:11470804
      assigned_by: UniProt
  - go_id: GO:0008794
    label: arsenate reductase (glutaredoxin) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 4
    rate_ratio: 0.0137
    p_value: 7.02e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9NS18
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:11297543
      assigned_by: UniProt
    - protein: UniProtKB:Q9NS18
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:11397793
      assigned_by: UniProt
  - go_id: GO:0033797
    label: selenate reductase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 8
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0137
    p_value: 4.39e-09
    q_value: 2.26e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1W2P6U1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:61959
    - protein: UniProtKB:Q9JMH6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:61959
  - go_id: GO:0032196
    label: transposition
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0137
    p_value: 7.02e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P51521
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18791225
      assigned_by: FlyBase
  - go_id: GO:0005814
    label: centriole
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1492
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 16
    rate_ratio: 0.0137
    p_value: 1.76e-29
    q_value: 3.31e-28
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O94455
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1347085|MGI:MGI:2677454|PANTHER:PTN000549683|UniProtKB:P41208|UniProtKB:Q12798
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005814
  - go_id: GO:0022626
    label: cytosolic ribosome
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 969
      Archaea: 2
      Bacteria: 1
      Fungi: 44
      Plants: 234
    rate_ratio: 0.0138
    p_value: 3.82e-26
    q_value: 6.2e-25
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q2EEQ2
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:30359641
      assigned_by: EcoCyc
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0022626
  - go_id: GO:0003995
    label: acyl-CoA dehydrogenase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 348
      Archaea: 15
      Bacteria: 41
      Fungi: 1
      Plants: 11
    rate_ratio: 0.0138
    p_value: 8.6e-11
    q_value: 5.2e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PTU4
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0035811|MGI:MGI:1919235|MGI:MGI:2143169|MGI:MGI:87866|MGI:MGI:87867|PANTHER:PTN002535634|RGD:2011|RGD:2012|UniProtKB:P11310|UniProtKB:P28330|UniProtKB:P9WQG3|UniProtKB:Q47146|UniProtKB:Q6JQN1|UniProtKB:Q709F0
  - go_id: GO:0042149
    label: cellular response to glucose starvation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 241
      Archaea: 0
      Bacteria: 0
      Fungi: 60
      Plants: 3
    rate_ratio: 0.0138
    p_value: 5.16e-36
    q_value: 1.27e-34
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T658
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G09020|PANTHER:PTN008551371
    - protein: UniProtKB:D8T7U4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G09020|PANTHER:PTN008551371
    - protein: UniProtKB:Q944A6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G09020|PANTHER:PTN008551371
    - protein: UniProtKB:Q944A6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:10929106
      assigned_by: TAIR
  - go_id: GO:1990023
    label: mitotic spindle midzone
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 86
      Archaea: 0
      Bacteria: 0
      Fungi: 40
      Plants: 2
    rate_ratio: 0.0138
    p_value: 2.8e-24
    q_value: 4.06e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4ICA0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000180294|FB:FBgn0004379|MGI:MGI:2446977|PANTHER:PTN000649974|PomBase:SPBC1685.15c|PomBase:SPBC2F12.13|SGD:S000003184
    - protein: UniProtKB:Q8LEG3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19060108
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1990023
  - go_id: GO:0000393
    label: spliceosomal conformational changes to generate catalytic conformation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 2
    rate_ratio: 0.014
    p_value: 3.15e-08
    q_value: 1.47e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P34369
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089929
    - protein: UniProtKB:Q9U2G0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089929
  - go_id: GO:0097163
    label: sulfur carrier activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 9
      Archaea: 2
      Bacteria: 22
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0141
    p_value: 6.17e-13
    q_value: 4.48e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FXE3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000978101|UniProtKB:P0AGF2|UniProtKB:P76194
  - go_id: GO:0009009
    label: site-specific recombinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 22
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0141
    p_value: 6.17e-13
    q_value: 4.48e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RBV8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001251457|UniProtKB:P0A8P6|UniProtKB:P0A8P8
  - go_id: GO:0043168
    label: anion binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 112
      Archaea: 8
      Bacteria: 4
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0143
    p_value: 5.91e-09
    q_value: 2.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JXM5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026944
    - protein: UniProtKB:Q9FHN8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026944
  - go_id: GO:0055086
    label: nucleobase-containing small molecule metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 150
      Archaea: 4
      Bacteria: 14
      Fungi: 13
      Plants: 1
    rate_ratio: 0.0143
    p_value: 8.15e-05
    q_value: 0.000239
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9S847
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027681
  - go_id: GO:0006220
    label: pyrimidine nucleotide metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 26
      Archaea: 4
      Bacteria: 8
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0143
    p_value: 8.15e-05
    q_value: 0.000239
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RFM2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR016473
  - go_id: GO:0006824
    label: cobalt ion transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 19
      Archaea: 8
      Bacteria: 24
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0143
    p_value: 5.91e-09
    q_value: 2.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KGN5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19861554
      assigned_by: TAIR
    - protein: UniProtKB:O80905
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19861554
      assigned_by: TAIR
  - go_id: GO:0140671
    label: ADA complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 0
    rate_ratio: 0.0147
    p_value: 2.41e-11
    q_value: 1.53e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9PHZ1
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:30715476
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q9VTZ1
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:30715476
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q9W2I4
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:30715476
      assigned_by: ComplexPortal
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0140671
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0140671
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0140671
  - go_id: GO:0005796
    label: Golgi lumen
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 385
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0147
    p_value: 7.06e-26
    q_value: 1.13e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9M9N9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25681330
      assigned_by: TAIR
    - protein: UniProtKB:Q9M9N9
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:25681330
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G03210
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0005796
  - go_id: GO:0008305
    label: integrin complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 384
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0147
    p_value: 8.29e-26
    q_value: 1.32e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0DI79
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:10196471
      assigned_by: TAIR
  - go_id: GO:0060966
    label: regulation of gene silencing by regulatory ncRNA
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 12
    rate_ratio: 0.0147
    p_value: 2.96e-09
    q_value: 1.55e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O62275
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:30728462
      assigned_by: UniProt
      gene_review: genes/worm/wago-4/wago-4-ai-review.yaml
  - go_id: GO:0003925
    label: G protein activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1226
      Archaea: 0
      Bacteria: 1
      Fungi: 42
      Plants: 52
    rate_ratio: 0.0149
    p_value: 4.64e-27
    q_value: 7.83e-26
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P76046
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.6.5.2
  - go_id: GO:0046296
    label: glycolate catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 11
      Fungi: 0
      Plants: 0
    rate_ratio: 0.015
    p_value: 4.75e-12
    q_value: 3.21e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E1BRR7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008948292|UniProtKB:Q9UJM8
    - protein: UniProtKB:E1BRR7
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9UJM8|ensembl:ENSP00000368066
    - protein: UniProtKB:Q9UJM8
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008948292|UniProtKB:Q9UJM8
      gene_review: genes/human/HAO1/HAO1-ai-review.yaml
    - protein: UniProtKB:Q9UJM8
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:18215067
      assigned_by: UniProt
      gene_review: genes/human/HAO1/HAO1-ai-review.yaml
    - protein: UniProtKB:Q9WU19
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008948292|UniProtKB:Q9UJM8
    - protein: UniProtKB:Q9WU19
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9UJM8|ensembl:ENSP00000368066
    - protein: UniProtKB:Q9WU19
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9UJM8
    - protein: UniProtKB:Q9WU19
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9UJM8
  - go_id: GO:0045471
    label: response to ethanol
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 374
      Archaea: 0
      Bacteria: 3
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0151
    p_value: 4.12e-25
    q_value: 6.24e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8S926
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33028029
      assigned_by: TAIR
  - go_id: GO:0050560
    label: aspartate-tRNA(Asn) ligase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 2
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0151
    p_value: 0.00196
    q_value: 0.0044
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Y1V0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q6PI48|ensembl:ENSP00000497569
    - protein: UniProtKB:Q6PI48
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:15779907
      assigned_by: BHF-UCL
      gene_review: genes/human/DARS2/DARS2-ai-review.yaml
    - protein: UniProtKB:Q6PI48
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:17384640
      assigned_by: BHF-UCL
      gene_review: genes/human/DARS2/DARS2-ai-review.yaml
    - protein: UniProtKB:Q8BIP0
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q6PI48|ensembl:ENSP00000497569
    - protein: UniProtKB:Q8BIP0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q6PI48
  - go_id: GO:0031405
    label: lipoic acid binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 2
      Bacteria: 6
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0151
    p_value: 0.00196
    q_value: 0.0044
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A140LI30
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2917
    - protein: UniProtKB:A0A140LIH1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2917
    - protein: UniProtKB:P15208
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2917
  - go_id: GO:0004845
    label: uracil phosphoribosyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 2
      Bacteria: 9
      Fungi: 5
      Plants: 6
    rate_ratio: 0.0151
    p_value: 0.00196
    q_value: 0.0044
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9PHI7
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26271729
      assigned_by: FlyBase
    - protein: UniProtKB:O61790
      taxon: NCBITaxon:6239
      evidence: EXP
      reference: PMID:19645718
      assigned_by: UniProt
    - protein: UniProtKB:O61790
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.2.9
    - protein: UniProtKB:O61790
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13017
    - protein: UniProtKB:Q9VRQ1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26271729
      assigned_by: FlyBase
  - go_id: GO:1990133
    label: molybdopterin adenylyltransferase complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 3
      Archaea: 2
      Bacteria: 5
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0151
    p_value: 0.00196
    q_value: 0.0044
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0C919
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008655638|UniProtKB:P30748
    - protein: UniProtKB:P0C919
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P30748
    - protein: UniProtKB:Q09412
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008655638|UniProtKB:P30748
    - protein: UniProtKB:Q9VLJ8
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P12282
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1990133
  - go_id: GO:0009787
    label: regulation of abscisic acid-activated signaling pathway
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 35
    rate_ratio: 0.0152
    p_value: 1.62e-25
    q_value: 2.53e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XMZ9
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G52920|PANTHER:PTN000296773|UniProtKB:Q9NS86
    - protein: UniProtKB:Q9JJK2
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G52920|PANTHER:PTN000296773|UniProtKB:Q9NS86
    - protein: UniProtKB:Q9NS86
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G52920|PANTHER:PTN000296773|UniProtKB:Q9NS86
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0009787
  - go_id: GO:0045596
    label: negative regulation of cell differentiation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 370
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0153
    p_value: 7.81e-25
    q_value: 1.17e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9MA75
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15108305
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045596
  - go_id: GO:0140311
    label: protein sequestering activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 369
      Archaea: 0
      Bacteria: 1
      Fungi: 17
      Plants: 1
    rate_ratio: 0.0153
    p_value: 9.17e-25
    q_value: 1.37e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LSZ8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:42203875
      assigned_by: TAIR
  - go_id: GO:0070888
    label: E-box binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 369
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0153
    p_value: 9.17e-25
    q_value: 1.37e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LND0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:33393464
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G75910
    - protein: UniProtKB:Q9LND0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:33393464
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G15400
    - protein: UniProtKB:Q9LND0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:33393464
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G28470
    - protein: UniProtKB:Q9LND0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:33393464
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G14080
  - go_id: GO:0016050
    label: vesicle organization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 154
      Archaea: 0
      Bacteria: 0
      Fungi: 18
      Plants: 1
    rate_ratio: 0.0153
    p_value: 3.29e-11
    q_value: 2.06e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O80796
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:11274447
      assigned_by: TAIR
  - go_id: GO:0015871
    label: choline transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 222
      Archaea: 2
      Bacteria: 20
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0155
    p_value: 1.0e-11
    q_value: 6.58e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AN2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25008948
      assigned_by: TAIR
    - protein: UniProtKB:Q94AN2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27743414
      assigned_by: UniProt
  - go_id: GO:0007156
    label: homophilic cell-cell adhesion
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1163
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0157
    p_value: 1.28e-25
    q_value: 2.01e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8ZKG6
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002126
  - go_id: GO:0004197
    label: cysteine-type endopeptidase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1161
      Archaea: 0
      Bacteria: 1
      Fungi: 14
      Plants: 136
    rate_ratio: 0.0157
    p_value: 1.42e-25
    q_value: 2.23e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q183M1
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.4.22.15|EC:3.4.22.15
    - protein: UniProtKB:Q183M1
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000415274
  - go_id: GO:0007035
    label: vacuolar acidification
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 79
      Archaea: 3
      Bacteria: 1
      Fungi: 56
      Plants: 20
    rate_ratio: 0.0159
    p_value: 2.97e-17
    q_value: 2.89e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q184E8
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000179707
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0007035
  - go_id: GO:0016756
    label: glutathione gamma-glutamylcysteinyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 11
    rate_ratio: 0.0161
    p_value: 1.82e-08
    q_value: 8.71e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: EXP
      reference: PMID:20221439
      assigned_by: UniProt
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G03980|AGI_LocusCode:AT5G44070|PANTHER:PTN002124892|PomBase:SPAC3H1.10|WB:WBGene00003960
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:11313333
      assigned_by: WB
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007719|InterPro:IPR040409
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.2.15
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:17917
    - protein: UniProtKB:A5JYS0
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00087654
  - go_id: GO:0031930
    label: mitochondria-nucleus signaling pathway
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 12
    rate_ratio: 0.0163
    p_value: 3.99e-10
    q_value: 2.28e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E1C5T1
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q3TZX3|ensembl:ENSMUSP00000101311
    - protein: UniProtKB:Q3TZX3
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:17596519
      assigned_by: UniProt
    - protein: UniProtKB:Q9BSK2
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q3TZX3|ensembl:ENSMUSP00000101311
    - protein: UniProtKB:Q9BSK2
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q3TZX3
  - go_id: GO:0006030
    label: chitin metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0163
    p_value: 5.27e-07
    q_value: 2.13e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9BZP6
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:10548734
      assigned_by: UniProt
    - protein: UniProtKB:Q9VW34
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:31108167
      assigned_by: FlyBase
  - go_id: GO:0035822
    label: gene conversion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9H1E3
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:26323318
      assigned_by: ParkinsonsUK-UCL
  - go_id: GO:0044377
    label: RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P53568
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2330
  - go_id: GO:0019255
    label: glucose 1-phosphate metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q91ZJ5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1310210
  - go_id: GO:0140659
    label: cytoskeletal motor regulator activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9D3N2
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000008
      assigned_by: MGI
      with_from: UniProtKB:Q8T893
  - go_id: GO:0042939
    label: tripeptide transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 8
      Fungi: 9
      Plants: 26
    rate_ratio: 0.0163
    p_value: 3.99e-10
    q_value: 2.28e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q17758
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0042937
    - protein: UniProtKB:Q21219
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0042937
    - protein: UniProtKB:Q9JIP7
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0042937
  - go_id: GO:0090154
    label: positive regulation of sphingolipid biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E2QCD0
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:26395456
      assigned_by: FlyBase
  - go_id: GO:1990616
    label: magnesium ion export from mitochondrion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VM51
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26462626
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VM51
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:26462626
      assigned_by: FlyBase
  - go_id: GO:1990624
    label: guanyl nucleotide exchange factor inhibitor activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VR38
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:37463208
      assigned_by: UniProt
      gene_review: genes/DROME/Mon1/Mon1-ai-review.yaml
  - go_id: GO:1990139
    label: protein localization to nuclear periphery
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VV73
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:34337769
      assigned_by: FlyBase
  - go_id: GO:0098653
    label: centromere clustering
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 1
    rate_ratio: 0.0163
    p_value: 3.99e-10
    q_value: 2.28e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VX37
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:24913682
      assigned_by: FlyBase
    - protein: UniProtKB:Q9W3W9
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:40744629
      assigned_by: FlyBase
    - protein: UniProtKB:X2JKX2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:24913682
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0098653
  - go_id: GO:0046495
    label: nicotinamide riboside metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VZR0
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P53915
  - go_id: GO:0007107
    label: membrane addition at site of cytokinesis
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W4X9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22685323
      assigned_by: FlyBase
      gene_review: genes/DROME/Zw10/Zw10-ai-review.yaml
  - go_id: GO:0010973
    label: positive regulation of division septum assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0163
    p_value: 0.00078
    q_value: 0.00191
    flagged_in_2019_or_2018: true
    flagged_annotations:
    - protein: UniProtKB:Q9N4A7
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:12937276
      assigned_by: UniProt
      gene_review: genes/worm/npp-20/npp-20-ai-review.yaml
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2 or NCBITaxon:4751 (Fungi or Bacteria), on GO:0010973
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2 or NCBITaxon:4751 (Fungi or Bacteria), on GO:0010973
  - go_id: GO:0005304
    label: L-valine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 19
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0163
    p_value: 4.04e-11
    q_value: 2.51e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84MA5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8618839
      assigned_by: UniProt
  - go_id: GO:0015293
    label: symporter activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 313
      Archaea: 0
      Bacteria: 68
      Fungi: 1
      Plants: 13
    rate_ratio: 0.0165
    p_value: 1.04e-17
    q_value: 1.05e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PHJ7
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000196014|MGI:MGI:2137361|PANTHER:PTN000063482|RGD:61840|RGD:621223|UniProtKB:O00337|UniProtKB:O43868|UniProtKB:O62667|UniProtKB:P0AFF2
    - protein: UniProtKB:A0A1D8PHJ7
      taxon: NCBITaxon:237561
      evidence: IDA
      reference: PMID:15543539
      assigned_by: CGD
  - go_id: GO:0140374
    label: antiviral innate immune response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 677
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0167
    p_value: 1.43e-44
    q_value: 4.68e-43
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q93VT9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19112492
      assigned_by: UniProt
    - protein: UniProtKB:Q9LFS4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19112492
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0140374
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0140374
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0140374
  - go_id: GO:0034644
    label: cellular response to UV
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 338
      Archaea: 0
      Bacteria: 5
      Fungi: 14
      Plants: 1
    rate_ratio: 0.0167
    p_value: 1.31e-22
    q_value: 1.76e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C7X0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25656510
      assigned_by: UniProt
  - go_id: GO:0000502
    label: proteasome complex
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 589
      Archaea: 2
      Bacteria: 2
      Fungi: 106
      Plants: 101
    rate_ratio: 0.0168
    p_value: 7.11e-32
    q_value: 1.51e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O25253
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029017
    - protein: UniProtKB:P39070
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029017
  - go_id: GO:0000722
    label: telomere maintenance via recombination
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 50
      Archaea: 0
      Bacteria: 1
      Fungi: 53
      Plants: 4
    rate_ratio: 0.0168
    p_value: 2.7e-16
    q_value: 2.48e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZAI7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN007664302
  - go_id: GO:0033116
    label: endoplasmic reticulum-Golgi intermediate compartment membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 335
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 1
    rate_ratio: 0.0169
    p_value: 2.11e-22
    q_value: 2.81e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SIN7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0099
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0033116
  - go_id: GO:1902495
    label: transmembrane transporter complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 252
      Archaea: 0
      Bacteria: 55
      Fungi: 2
      Plants: 3
    rate_ratio: 0.0169
    p_value: 1.1e-30
    q_value: 2.18e-29
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94JS0
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026587
    - protein: UniProtKB:Q9LYR2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026587
    - protein: UniProtKB:Q9ZUT3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: EnsemblPlants
      with_from: UniProtKB:Q5W7C1|RAP2022-09-01:Os05t0119000-01
  - go_id: GO:0005246
    label: calcium channel regulator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 329
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0172
    p_value: 5.52e-22
    q_value: 7.19e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RUD1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001031746|RGD:1304641|RGD:1306831|UniProtKB:Q13586|UniProtKB:Q9P246|WB:WBGene00021910
    - protein: UniProtKB:D8RUD1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR037608
  - go_id: GO:0140331
    label: aminophospholipid translocation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 52
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 1
    rate_ratio: 0.0173
    p_value: 6.3e-10
    q_value: 3.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XIE6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015247
  - go_id: GO:0004865
    label: protein serine/threonine phosphatase inhibitor activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 73
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 1
    rate_ratio: 0.0173
    p_value: 6.3e-10
    q_value: 3.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8S8F7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011107
  - go_id: GO:0008157
    label: protein phosphatase 1 binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 205
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 1
    rate_ratio: 0.0173
    p_value: 6.3e-10
    q_value: 3.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8S8F7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0261624|PANTHER:PTN000464544
  - go_id: GO:0048312
    label: intracellular distribution of mitochondria
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 54
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 1
    rate_ratio: 0.0173
    p_value: 6.3e-10
    q_value: 3.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J5S1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:14617080
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0048312
  - go_id: GO:0015578
    label: mannose transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 1
    rate_ratio: 0.0173
    p_value: 6.3e-10
    q_value: 3.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LT15
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26893494
      assigned_by: TAIR
  - go_id: GO:1904262
    label: negative regulation of TORC1 signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 482
      Archaea: 0
      Bacteria: 0
      Fungi: 48
      Plants: 3
    rate_ratio: 0.0173
    p_value: 2.56e-28
    q_value: 4.58e-27
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S7M9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000366325|UniProtKB:P54252
    - protein: UniProtKB:D8T401
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000366325|UniProtKB:P54252
    - protein: UniProtKB:Q9M391
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000366325|UniProtKB:P54252
  - go_id: GO:0001784
    label: phosphotyrosine residue binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 325
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0174
    p_value: 1.05e-21
    q_value: 1.35e-20
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LJK1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:41577690
      assigned_by: TAIR
  - go_id: GO:0006363
    label: termination of RNA polymerase I transcription
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 33
      Archaea: 0
      Bacteria: 0
      Fungi: 47
      Plants: 3
    rate_ratio: 0.0176
    p_value: 1.12e-27
    q_value: 1.92e-26
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R331
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000133053|PomBase:SPCC1259.03|SGD:S000003824
    - protein: UniProtKB:D8SMF0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000133053|PomBase:SPCC1259.03|SGD:S000003824
    - protein: UniProtKB:Q9LU97
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000133053|PomBase:SPCC1259.03|SGD:S000003824
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0006363
  - go_id: GO:0008201
    label: heparin binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1032
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0177
    p_value: 1.24e-22
    q_value: 1.67e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P75857
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:27323865
      assigned_by: EcoCyc
  - go_id: GO:0051015
    label: actin filament binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 2004
      Archaea: 0
      Bacteria: 2
      Fungi: 88
      Plants: 146
    rate_ratio: 0.0182
    p_value: 3.53e-43
    q_value: 1.1e-41
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZEC8
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002241697
    - protein: UniProtKB:A0A0H2ZJG4
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002241713
  - go_id: GO:0065002
    label: intracellular protein transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 17
      Archaea: 9
      Bacteria: 51
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0183
    p_value: 2.82e-28
    q_value: 5.02e-27
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RAV0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000769484|UniProtKB:P69423
    - protein: UniProtKB:D8RH88
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000769484|UniProtKB:P69423
    - protein: UniProtKB:Q9SJV5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000769484|UniProtKB:P69423
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0065002
  - go_id: GO:0015112
    label: nitrate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 9
      Fungi: 0
      Plants: 25
    rate_ratio: 0.0183
    p_value: 1.06e-09
    q_value: 5.85e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A2R8VHB9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:71100
    - protein: UniProtKB:Q13520
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001452348|RGD:71100
    - protein: UniProtKB:Q8C4A0
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001452348|RGD:71100
    - protein: UniProtKB:Q8C4A0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:71100
  - go_id: GO:0015556
    label: C4-dicarboxylate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 9
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 1.06e-09
    q_value: 5.85e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E1JIQ7
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033521
    - protein: UniProtKB:Q0KI47
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033521
    - protein: UniProtKB:Q7KTF1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033521
  - go_id: GO:0008667
    label: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D6R9U8
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003560
  - go_id: GO:0005477
    label: pyruvate secondary active transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 1.01e-06
    q_value: 3.93e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4LFP5
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:30318245
      assigned_by: FlyBase
    - protein: UniProtKB:O60669
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9786900
      assigned_by: PINC
  - go_id: GO:0016679
    label: oxidoreductase activity, acting on diphenols and related substances as donors
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 1.01e-06
    q_value: 3.93e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P00184
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P00185|ensembl:ENSRNOP00000026473
      gene_review: genes/mouse/Cyp1a1/Cyp1a1-ai-review.yaml
    - protein: UniProtKB:P00184
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2458
      gene_review: genes/mouse/Cyp1a1/Cyp1a1-ai-review.yaml
    - protein: UniProtKB:P04798
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P00185|ensembl:ENSRNOP00000026473
  - go_id: GO:0008995
    label: ribonuclease E activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q12972
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9153239
      assigned_by: PINC
  - go_id: GO:0003957
    label: NAD(P)+ transhydrogenase (Si-specific) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q13423
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9524818
      assigned_by: UniProt
  - go_id: GO:0015904
    label: tetracycline transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q14728
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0008493
  - go_id: GO:0008653
    label: lipopolysaccharide metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 1.01e-06
    q_value: 3.93e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1Y7VJ47
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:15155618
      assigned_by: MGI
    - protein: UniProtKB:O35298
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:15155618
      assigned_by: MGI
  - go_id: GO:0032272
    label: negative regulation of protein polymerization
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q60930
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:12881569
      assigned_by: UniProt
  - go_id: GO:0042619
    label: poly-hydroxybutyrate biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9Z2A7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:628673
  - go_id: GO:0000719
    label: photoreactive repair
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 1
      Plants: 9
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YRT6
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G12370|PANTHER:PTN000025285
  - go_id: GO:0062132
    label: regulation of L-glutamine biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q04688
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19742324
      assigned_by: FlyBase
  - go_id: GO:0007105
    label: cytokinesis, division site positioning
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V4P1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:20237160
      assigned_by: FlyBase
  - go_id: GO:0002131
    label: wobble position cytosine ribose methylation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0183
    p_value: 0.00108
    q_value: 0.00256
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VDD9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:31943105
      assigned_by: FlyBase
  - go_id: GO:0008496
    label: mannan endo-1,6-alpha-mannosidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 0
    rate_ratio: 0.0183
    p_value: 6.44e-09
    q_value: 3.23e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Y9V3
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9Y2E5|ensembl:ENSP00000285599
    - protein: UniProtKB:O54782
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9Y2E5|ensembl:ENSP00000285599
    - protein: UniProtKB:Q9Y2E5
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:16115860
      assigned_by: MGI
  - go_id: GO:0042030
    label: ATPase inhibitor activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 56
      Archaea: 0
      Bacteria: 0
      Fungi: 15
      Plants: 1
    rate_ratio: 0.0184
    p_value: 2.74e-09
    q_value: 1.44e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SUA6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:30962395
      assigned_by: TAIR
  - go_id: GO:0007006
    label: mitochondrial membrane organization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 92
      Archaea: 0
      Bacteria: 0
      Fungi: 15
      Plants: 1
    rate_ratio: 0.0184
    p_value: 2.74e-09
    q_value: 1.44e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LVA9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23085019
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007006
  - go_id: GO:0016562
    label: protein import into peroxisome matrix, receptor recycling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 45
      Archaea: 0
      Bacteria: 0
      Fungi: 15
      Plants: 1
    rate_ratio: 0.0184
    p_value: 2.74e-09
    q_value: 1.44e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LGF7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:35595097
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0016562
  - go_id: GO:0032042
    label: mitochondrial DNA metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 31
      Archaea: 0
      Bacteria: 0
      Fungi: 15
      Plants: 1
    rate_ratio: 0.0184
    p_value: 2.74e-09
    q_value: 1.44e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84LK0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:12730382
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0032042
  - go_id: GO:0034097
    label: response to cytokine
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 306
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0185
    p_value: 2.17e-20
    q_value: 2.6e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0DO11
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:16832061
      assigned_by: UniProt
  - go_id: GO:0046942
    label: carboxylic acid transport
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 81
      Archaea: 11
      Bacteria: 12
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0188
    p_value: 7.53e-08
    q_value: 3.4e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P53322
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:10869563
      assigned_by: SGD
  - go_id: GO:0007219
    label: Notch signaling pathway
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 600
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0189
    p_value: 3.14e-39
    q_value: 8.52e-38
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QPY5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039398
    - protein: UniProtKB:D8SKI6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039398
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0007219
  - go_id: GO:0005102
    label: signaling receptor binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1933
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 41
    rate_ratio: 0.0189
    p_value: 1.46e-41
    q_value: 4.32e-40
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z852
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003060
    - protein: UniProtKB:A0A0H2ZF46
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003060
  - go_id: GO:0051049
    label: regulation of transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 299
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0189
    p_value: 6.64e-20
    q_value: 7.7e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R2Q2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027251
  - go_id: GO:0015459
    label: potassium channel regulator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 287
      Archaea: 3
      Bacteria: 9
      Fungi: 0
      Plants: 1
    rate_ratio: 0.019
    p_value: 0.00121
    q_value: 0.00283
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RMS5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000414538
  - go_id: GO:0009008
    label: DNA-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 17
      Archaea: 6
      Bacteria: 14
      Fungi: 0
      Plants: 2
    rate_ratio: 0.019
    p_value: 1.27e-06
    q_value: 4.83e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LFA9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:37944704
      assigned_by: TAIR
    - protein: UniProtKB:Q9M548
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:17239600
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G69770|AGI_LocusCode:AT5G15380
    - protein: UniProtKB:Q9M548
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21212233
      assigned_by: CACAO
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0009008
  - go_id: GO:0098552
    label: side of membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 7
      Archaea: 3
      Bacteria: 2
      Fungi: 1
      Plants: 1
    rate_ratio: 0.019
    p_value: 0.00121
    q_value: 0.00283
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QNF6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027303
  - go_id: GO:0031293
    label: membrane protein intracellular domain proteolysis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 56
      Archaea: 3
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.019
    p_value: 0.00121
    q_value: 0.00283
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JUU5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN004417004|UniProtKB:O43462
  - go_id: GO:0034023
    label: 5-(carboxyamino)imidazole ribonucleotide mutase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 5
      Fungi: 0
      Plants: 1
    rate_ratio: 0.019
    p_value: 0.00121
    q_value: 0.00283
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SJ42
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000549177|UniProtKB:P0AG18
  - go_id: GO:0045490
    label: pectin catabolic process
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 190
    rate_ratio: 0.019
    p_value: 6.24e-19
    q_value: 6.8e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001275777|SGD:S000003914|UniProtKB:Q5ATQ3|UniProtKB:Q5B508
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:10028181
      assigned_by: SGD
  - go_id: GO:0008301
    label: DNA binding, bending
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 58
      Archaea: 0
      Bacteria: 2
      Fungi: 29
      Plants: 2
    rate_ratio: 0.0191
    p_value: 3.1e-17
    q_value: 3.01e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C7B1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15688221
      assigned_by: TAIR
    - protein: UniProtKB:Q9SNB9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15688221
      assigned_by: TAIR
  - go_id: GO:0005815
    label: microtubule organizing center
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 952
      Archaea: 0
      Bacteria: 1
      Fungi: 40
      Plants: 64
    rate_ratio: 0.0191
    p_value: 8.24e-21
    q_value: 1.01e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKN9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000436624
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005815
  - go_id: GO:0007204
    label: positive regulation of cytosolic calcium ion concentration
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 589
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0192
    p_value: 1.81e-38
    q_value: 4.82e-37
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I5N6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15824136
      assigned_by: TAIR
    - protein: UniProtKB:Q1ECR9
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:31004454
      assigned_by: DisProt
  - go_id: GO:1990748
    label: cellular detoxification
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 49
      Archaea: 0
      Bacteria: 1
      Fungi: 46
      Plants: 4
    rate_ratio: 0.0194
    p_value: 4.59e-14
    q_value: 3.57e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P25526
      taxon: NCBITaxon:83333
      evidence: TAS
      reference: PMID:20174634
      assigned_by: UniProt
  - go_id: GO:0043610
    label: regulation of carbohydrate utilization
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 3
      Fungi: 5
      Plants: 2
    rate_ratio: 0.0195
    p_value: 8.5e-06
    q_value: 2.9e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0C5B5G6
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:25738459
      assigned_by: UniProt
      gene_review: genes/human/MT-RNR1__A0A0C5B5G6/MT-RNR1__A0A0C5B5G6-ai-review.yaml
    - protein: UniProtKB:Q9JLN9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:68371
      gene_review: genes/mouse/Mtor/Mtor-ai-review.yaml
  - go_id: GO:1900079
    label: regulation of arginine biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 4
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0195
    p_value: 8.5e-06
    q_value: 2.9e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q13286
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q61124|ensembl:ENSMUSP00000032962
      gene_review: genes/human/CLN3/CLN3-ai-review.yaml
    - protein: UniProtKB:Q13286
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q61124
      gene_review: genes/human/CLN3/CLN3-ai-review.yaml
    - protein: UniProtKB:Q61124
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19284480
      assigned_by: UniProt
  - go_id: GO:0071562
    label: nucleus-vacuole junction assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.0195
    p_value: 8.5e-06
    q_value: 2.9e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XKW8
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045156
    - protein: UniProtKB:A0A8V0XTI8
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045156
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071562
  - go_id: GO:1904564
    label: cytosolic [4Fe-4S] assembly scaffold complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.0195
    p_value: 8.5e-06
    q_value: 2.9e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VJI9
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P52920
    - protein: UniProtKB:Q9VPD2
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P40558
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1904564
  - go_id: GO:0043033
    label: isoamylase complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 9
    rate_ratio: 0.0196
    p_value: 6.75e-07
    q_value: 2.68e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P35573
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:1374391
      assigned_by: PINC
      gene_review: genes/human/AGL/AGL-ai-review.yaml
  - go_id: GO:0008447
    label: L-ascorbate oxidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 9
    rate_ratio: 0.0196
    p_value: 6.75e-07
    q_value: 2.68e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VLC3
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:25701385
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VLC3
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.10.3.3|EC:1.10.3.3|EC:1.10.3.3
  - go_id: GO:0034501
    label: protein localization to kinetochore
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 102
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 1
    rate_ratio: 0.0197
    p_value: 1.19e-08
    q_value: 5.78e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JT58
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:34850467
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G35520
  - go_id: GO:0034455
    label: t-UTP complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 14
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 1
    rate_ratio: 0.0197
    p_value: 1.19e-08
    q_value: 5.78e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JWG2
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:26555280
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G47990
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0034455
  - go_id: GO:0048018
    label: receptor ligand activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 919
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 25
    rate_ratio: 0.0198
    p_value: 4.64e-20
    q_value: 5.43e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P06179
      taxon: NCBITaxon:99287
      evidence: IDA
      reference: PMID:14625549
      assigned_by: UniProt
  - go_id: GO:2000026
    label: regulation of multicellular organismal development
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 284
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0199
    p_value: 7.26e-19
    q_value: 7.87e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22446
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:11134508
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:2000026
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:2000026
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:2000026
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:2000026
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:2000026
  - go_id: GO:0006805
    label: xenobiotic metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 564
      Archaea: 0
      Bacteria: 3
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0201
    p_value: 9.75e-37
    q_value: 2.47e-35
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9M0G0
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:17316176
      assigned_by: TAIR
    - protein: UniProtKB:Q9M156
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15860014
      assigned_by: TAIR
  - go_id: GO:0035235
    label: ionotropic glutamate receptor signaling pathway
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 280
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0202
    p_value: 1.37e-18
    q_value: 1.46e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C8E7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0022849
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0035235
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0035235
  - go_id: GO:0001221
    label: transcription coregulator binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 279
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0203
    p_value: 1.61e-18
    q_value: 1.7e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O82132
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:27881680
      assigned_by: DisProt
      gene_review: genes/ARATH/DREB2A/DREB2A-ai-review.yaml
  - go_id: GO:0016324
    label: apical plasma membrane
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 3023
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 40
    rate_ratio: 0.0203
    p_value: 2.3e-57
    q_value: 1.02e-55
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PKK4
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:101924|MGI:MGI:103150|MGI:MGI:108114|PANTHER:PTN002274228|RGD:3685|RGD:3686|UniProtKB:P55011|UniProtKB:P55017|UniProtKB:Q13621|WB:WBGene00019289|ZFIN:ZDB-GENE-080130-3
    - protein: UniProtKB:O60146
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:101924|MGI:MGI:103150|MGI:MGI:108114|PANTHER:PTN002274228|RGD:3685|RGD:3686|UniProtKB:P55011|UniProtKB:P55017|UniProtKB:Q13621|WB:WBGene00019289|ZFIN:ZDB-GENE-080130-3
    - protein: UniProtKB:P38329
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:101924|MGI:MGI:103150|MGI:MGI:108114|PANTHER:PTN002274228|RGD:3685|RGD:3686|UniProtKB:P55011|UniProtKB:P55017|UniProtKB:Q13621|WB:WBGene00019289|ZFIN:ZDB-GENE-080130-3
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0016324
  - go_id: GO:1902895
    label: positive regulation of miRNA transcription
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 278
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0203
    p_value: 1.89e-18
    q_value: 1.98e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KF35
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:35260568
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:1902895
  - go_id: GO:0007166
    label: cell surface receptor signaling pathway
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 2008
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 108
    rate_ratio: 0.0204
    p_value: 2.29e-38
    q_value: 6.05e-37
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P42838
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:11063677
      assigned_by: SGD
    - protein: UniProtKB:P87179
      taxon: NCBITaxon:284812
      evidence: IC
      reference: GO_REF:0000111
      assigned_by: PomBase
      with_from: GO:0004888
      gene_review: genes/SCHPO/wsc1/wsc1-ai-review.yaml
  - go_id: GO:0017183
    label: protein histidyl modification to diphthamide
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 138
      Archaea: 9
      Bacteria: 1
      Fungi: 27
      Plants: 27
    rate_ratio: 0.0204
    p_value: 9.08e-07
    q_value: 3.55e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18BT6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000257633
  - go_id: GO:0015707
    label: nitrite transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 8
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0206
    p_value: 1.54e-08
    q_value: 7.41e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A087WNR0
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:8529105
      assigned_by: MGI
    - protein: UniProtKB:P41251
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:8529105
      assigned_by: MGI
    - protein: UniProtKB:P49279
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:P41251
  - go_id: GO:0090071
    label: negative regulation of ribosome biogenesis
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 8
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0206
    p_value: 1.54e-08
    q_value: 7.41e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O08586
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18082964
      assigned_by: CACAO
      gene_review: genes/mouse/Pten/Pten-ai-review.yaml
    - protein: UniProtKB:P34611
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:28853436
      assigned_by: UniProt
    - protein: UniProtKB:P34611
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:9508766
      assigned_by: WB
    - protein: UniProtKB:Q64364
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:20513429
      assigned_by: UniProt
  - go_id: GO:0042834
    label: peptidoglycan binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 94
      Archaea: 0
      Bacteria: 30
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0207
    p_value: 1.01e-16
    q_value: 9.54e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6NPN4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G21880|AGI_LocusCode:AT1G77630|PANTHER:PTN001915799
    - protein: UniProtKB:Q6NPN4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22106285
      assigned_by: TAIR
    - protein: UniProtKB:Q93ZH0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G21880|AGI_LocusCode:AT1G77630|PANTHER:PTN001915799
    - protein: UniProtKB:Q93ZH0
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22106285
      assigned_by: TAIR
  - go_id: GO:0000993
    label: RNA polymerase II complex binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 226
      Archaea: 0
      Bacteria: 1
      Fungi: 43
      Plants: 27
    rate_ratio: 0.0207
    p_value: 4.11e-13
    q_value: 3.03e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18D11
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000361535
  - go_id: GO:0061809
    label: NAD+ nucleosidase activity, cyclic ADP-ribose generating
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 55
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 155
    rate_ratio: 0.0208
    p_value: 4.8e-17
    q_value: 4.63e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P96648
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.2.2.6
  - go_id: GO:0043436
    label: oxoacid metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 17
    rate_ratio: 0.0208
    p_value: 2.55e-12
    q_value: 1.77e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P20478
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027279
    - protein: UniProtKB:X2JDA5
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027279
  - go_id: GO:0005272
    label: sodium channel activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 271
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0209
    p_value: 5.76e-18
    q_value: 5.87e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9M8W7
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18625242
      assigned_by: UniProt
  - go_id: GO:0015980
    label: energy derivation by oxidation of organic compounds
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 0
    rate_ratio: 0.0209
    p_value: 1.01e-07
    q_value: 4.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0ACI8UJF7
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026991
    - protein: UniProtKB:P49748
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:7479827
      assigned_by: PINC
      gene_review: genes/human/ACADVL/ACADVL-ai-review.yaml
    - protein: UniProtKB:Q08AH1
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:11470804
      assigned_by: UniProt
  - go_id: GO:1990626
    label: mitochondrial outer membrane fusion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 0
    rate_ratio: 0.0209
    p_value: 1.01e-07
    q_value: 4.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Z6S4
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q13232|ensembl:ENSP00000219302
    - protein: UniProtKB:Q13232
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:37584589
      assigned_by: UniProt
    - protein: UniProtKB:Q9WV85
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q13232|ensembl:ENSP00000219302
    - protein: UniProtKB:Q9WV85
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q13232
    - protein: UniProtKB:Q9WV85
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q13232
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990626
  - go_id: GO:0032160
    label: septin filament array
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 0
    rate_ratio: 0.0209
    p_value: 1.01e-07
    q_value: 4.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E9Q1G8
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:22232702
      assigned_by: MGI
    - protein: UniProtKB:E9Q9F5
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:22232702
      assigned_by: MGI
    - protein: UniProtKB:O55131
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:22232702
      assigned_by: MGI
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0032160
  - go_id: GO:0003825
    label: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 1
      Bacteria: 2
      Fungi: 7
      Plants: 13
    rate_ratio: 0.0209
    p_value: 1.01e-07
    q_value: 4.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O45380
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027560|PANTHER:PTN000082164
    - protein: UniProtKB:O45380
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.1.15
    - protein: UniProtKB:O45380
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:18889
    - protein: UniProtKB:Q7YZT6
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027560|PANTHER:PTN000082164
    - protein: UniProtKB:Q7YZT6
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.1.15
    - protein: UniProtKB:Q7YZT6
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:18889
    - protein: UniProtKB:Q9Y119
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027560|PANTHER:PTN000082164
      gene_review: genes/DROME/Tps1/Tps1-ai-review.yaml
    - protein: UniProtKB:Q9Y119
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:22762304
      assigned_by: FlyBase
      gene_review: genes/DROME/Tps1/Tps1-ai-review.yaml
    - protein: UniProtKB:Q9Y119
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.1.15|EC:2.4.1.15
      gene_review: genes/DROME/Tps1/Tps1-ai-review.yaml
  - go_id: GO:0004497
    label: monooxygenase activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1587
      Archaea: 1
      Bacteria: 34
      Fungi: 29
      Plants: 832
    rate_ratio: 0.021
    p_value: 7.92e-19
    q_value: 8.54e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q55080
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001128|InterPro:IPR002397|InterPro:IPR036396
  - go_id: GO:0009653
    label: anatomical structure morphogenesis
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 972
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 33
    rate_ratio: 0.0211
    p_value: 6.81e-19
    q_value: 7.4e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q59T43
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026583
  - go_id: GO:0098586
    label: cellular response to virus
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 268
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0211
    p_value: 9.28e-18
    q_value: 9.34e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FI46
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19840398
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0098586
  - go_id: GO:0140474
    label: mitochondrion-endoplasmic reticulum membrane tether activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 20
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 1
    rate_ratio: 0.0213
    p_value: 5.13e-08
    q_value: 2.34e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I8P4
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:36163196
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G60600
  - go_id: GO:0035869
    label: ciliary transition zone
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 530
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0213
    p_value: 2.19e-34
    q_value: 5.13e-33
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QTL3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107566|PANTHER:PTN000401088|WB:WBGene00002182
    - protein: UniProtKB:D8SBR2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107566|PANTHER:PTN000401088|WB:WBGene00002182
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0035869
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0035869
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0035869
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0035869
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0035869
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0035869
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0035869
  - go_id: GO:0016805
    label: dipeptidase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 134
      Archaea: 1
      Bacteria: 29
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0214
    p_value: 4.01e-16
    q_value: 3.62e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P30184
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25716890
      assigned_by: UniProt
    - protein: UniProtKB:Q8RX72
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25716890
      assigned_by: UniProt
  - go_id: GO:0072659
    label: protein localization to plasma membrane
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 843
      Archaea: 0
      Bacteria: 1
      Fungi: 19
      Plants: 23
    rate_ratio: 0.0216
    p_value: 2.47e-18
    q_value: 2.59e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O32076
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1100500|PANTHER:PTN008551622|UniProtKB:O75955|UniProtKB:Q14254
  - go_id: GO:0005998
    label: xylulose catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 5
      Fungi: 2
      Plants: 0
    rate_ratio: 0.022
    p_value: 1.46e-05
    q_value: 4.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O75191
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9763671
      assigned_by: BHF-UCL
    - protein: UniProtKB:Q21929
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:21477590
      assigned_by: WB
  - go_id: GO:0009403
    label: toxin biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 5
      Fungi: 0
      Plants: 0
    rate_ratio: 0.022
    p_value: 1.46e-05
    q_value: 4.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P00186
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P05177|ensembl:ENSP00000342007
    - protein: UniProtKB:P00186
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P05177
    - protein: UniProtKB:P05177
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:11511187
      assigned_by: BHF-UCL
  - go_id: GO:0042413
    label: carnitine catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 5
      Fungi: 0
      Plants: 0
    rate_ratio: 0.022
    p_value: 1.46e-05
    q_value: 4.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P28330
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:P51174
    - protein: UniProtKB:P51174
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:9861014
      assigned_by: BHF-UCL
      gene_review: genes/mouse/Acadl/Acadl-ai-review.yaml
  - go_id: GO:0015797
    label: mannitol transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 5
      Fungi: 4
      Plants: 1
    rate_ratio: 0.022
    p_value: 1.46e-05
    q_value: 4.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8CIW6
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:22021714
      assigned_by: UniProt
    - protein: UniProtKB:Q9BXS9
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8CIW6
      gene_review: genes/human/SLC26A6/SLC26A6-ai-review.yaml
  - go_id: GO:0008333
    label: endosome to lysosome transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 257
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.022
    p_value: 5.34e-17
    q_value: 5.12e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FG38
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:17999644
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0008333
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0008333
  - go_id: GO:0071345
    label: cellular response to cytokine stimulus
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 256
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0221
    p_value: 6.26e-17
    q_value: 5.99e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P48000
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19704797
      assigned_by: TAIR
  - go_id: GO:0140085
    label: L-amino-acid N-acetyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 8
    rate_ratio: 0.0221
    p_value: 4.05e-06
    q_value: 1.44e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0ACP2IEB2
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084890
  - go_id: GO:0016781
    label: phosphotransferase activity, paired acceptors
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 8
    rate_ratio: 0.0221
    p_value: 4.05e-06
    q_value: 1.44e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q22649
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00087648
  - go_id: GO:0047724
    label: inosine nucleosidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 8
    rate_ratio: 0.0221
    p_value: 4.05e-06
    q_value: 1.44e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: EXP
      reference: PMID:12777783
      assigned_by: UniProt
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:28218438
      assigned_by: UniProt
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.2.2.2
  - go_id: GO:0071469
    label: cellular response to alkaline pH
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 16
      Archaea: 0
      Bacteria: 0
      Fungi: 25
      Plants: 2
    rate_ratio: 0.0221
    p_value: 1.07e-14
    q_value: 8.76e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q940Y5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:36582637
      assigned_by: TAIR
    - protein: UniProtKB:Q9S7Z8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:36582637
      assigned_by: TAIR
      gene_review: genes/ARATH/PIN3/PIN3-ai-review.yaml
  - go_id: GO:2000144
    label: positive regulation of DNA-templated transcription initiation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 37
      Archaea: 0
      Bacteria: 14
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0222
    p_value: 4.09e-08
    q_value: 1.89e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94C37
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33631797
      assigned_by: TAIR
  - go_id: GO:0000470
    label: maturation of LSU-rRNA
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 56
      Archaea: 0
      Bacteria: 1
      Fungi: 40
      Plants: 32
    rate_ratio: 0.0223
    p_value: 3.68e-12
    q_value: 2.51e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P77766
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:32343306
      assigned_by: EcoCyc
    - protein: UniProtKB:P77766
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:32343306
      assigned_by: EcoCyc
  - go_id: GO:0001933
    label: negative regulation of protein phosphorylation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 250
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.0226
    p_value: 1.62e-16
    q_value: 1.5e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FNP4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27143545
      assigned_by: UniProt
  - go_id: GO:0045277
    label: respiratory chain complex IV
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 243
      Archaea: 0
      Bacteria: 1
      Fungi: 39
      Plants: 14
    rate_ratio: 0.0228
    p_value: 7.62e-12
    q_value: 5.06e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZK46
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033944
  - go_id: GO:0000786
    label: nucleosome
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 693
      Archaea: 0
      Bacteria: 1
      Fungi: 39
      Plants: 96
    rate_ratio: 0.0228
    p_value: 7.62e-12
    q_value: 5.06e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A6R3
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:10320479
      assigned_by: EcoCyc
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0000786
  - go_id: GO:0042242
    label: cobyrinic acid a,c-diamide synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 3
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0228
    p_value: 1.76e-05
    q_value: 5.74e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S6S2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004484
    - protein: UniProtKB:D8SNL9
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004484
  - go_id: GO:0044689
    label: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 2
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0228
    p_value: 1.76e-05
    q_value: 5.74e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RBF3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000540995|UniProtKB:Q57888
    - protein: UniProtKB:D8RBF3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.1.32|EC:4.3.1.32
    - protein: UniProtKB:D8RY80
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000540995|UniProtKB:Q57888
    - protein: UniProtKB:D8RY80
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.1.32|EC:4.3.1.32
  - go_id: GO:0001731
    label: formation of translation preinitiation complex
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 59
      Archaea: 8
      Bacteria: 1
      Fungi: 21
      Plants: 13
    rate_ratio: 0.023
    p_value: 5.27e-06
    q_value: 1.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZH16
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002291944
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0001731
  - go_id: GO:0140268
    label: endoplasmic reticulum-plasma membrane contact site
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 150
      Archaea: 0
      Bacteria: 0
      Fungi: 24
      Plants: 2
    rate_ratio: 0.023
    p_value: 4.58e-14
    q_value: 3.56e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7XA06
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33944955
      assigned_by: TAIR
    - protein: UniProtKB:Q9SKR2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:30126867
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0140268
  - go_id: GO:0030892
    label: mitotic cohesin complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 28
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 1
    rate_ratio: 0.023
    p_value: 2.2e-07
    q_value: 9.32e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q56YN8
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000434523|PomBase:SPAC10F6.09c|SGD:S000003610|UniProtKB:Q9UQE7
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030892
  - go_id: GO:0051292
    label: nuclear pore complex assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 58
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 1
    rate_ratio: 0.023
    p_value: 2.2e-07
    q_value: 9.32e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LN10
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:39890949
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G30840
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051292
  - go_id: GO:0042175
    label: nuclear outer membrane-endoplasmic reticulum membrane network
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 0
      Fungi: 24
      Plants: 2
    rate_ratio: 0.023
    p_value: 4.58e-14
    q_value: 3.56e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R2Z3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001256837|SGD:S000005724
    - protein: UniProtKB:Q9LE45
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:11161203
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0042175
  - go_id: GO:0006799
    label: polyphosphate biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 12
      Plants: 1
    rate_ratio: 0.023
    p_value: 2.2e-07
    q_value: 9.32e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8S403
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27080106
      assigned_by: UniProt
  - go_id: GO:0006171
    label: cAMP biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 244
      Archaea: 0
      Bacteria: 8
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0232
    p_value: 4.21e-16
    q_value: 3.8e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HT77
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:35597242
      assigned_by: UniProt
  - go_id: GO:0005254
    label: chloride channel activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 785
      Archaea: 0
      Bacteria: 1
      Fungi: 2
      Plants: 22
    rate_ratio: 0.0232
    p_value: 5.12e-17
    q_value: 4.92e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P76175
      taxon: NCBITaxon:83333
      evidence: RCA
      reference: PMID:10539975
      assigned_by: EcoCyc
  - go_id: GO:0004714
    label: transmembrane receptor protein tyrosine kinase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 784
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 30
    rate_ratio: 0.0232
    p_value: 5.39e-17
    q_value: 5.17e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q183Y9
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.10.1|EC:2.7.10.1
  - go_id: GO:0031397
    label: negative regulation of protein ubiquitination
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 243
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0233
    p_value: 4.94e-16
    q_value: 4.42e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HVZ5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26714275
      assigned_by: TAIR
  - go_id: GO:0033558
    label: protein lysine deacetylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 243
      Archaea: 0
      Bacteria: 2
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0233
    p_value: 4.94e-16
    q_value: 4.42e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q941D6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29061669
      assigned_by: UniProt
  - go_id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 725
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 3
    rate_ratio: 0.0234
    p_value: 2.43e-46
    q_value: 8.3e-45
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HVG8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.10.2
    - protein: UniProtKB:Q8L4H0
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.10.2
    - protein: UniProtKB:Q9LSC2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.10.2
  - go_id: GO:0016477
    label: cell migration
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1742
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 12
    rate_ratio: 0.0235
    p_value: 5.58e-33
    q_value: 1.25e-31
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P13649
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:10865906
      assigned_by: CGD
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0016477
    - protein: UniProtKB:Q59X67
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:10865906
      assigned_by: CGD
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0016477
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0016477
  - go_id: GO:0031004
    label: potassium ion-transporting ATPase complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0235
    p_value: 2.15e-07
    q_value: 9.12e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O60706
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q63563
      gene_review: genes/human/ABCC9/ABCC9-ai-review.yaml
    - protein: UniProtKB:Q09428
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q09429
      gene_review: genes/human/ABCC8/ABCC8-ai-review.yaml
    - protein: UniProtKB:Q15842
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q63664
  - go_id: GO:0034338
    label: short-chain carboxylesterase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 7
      Fungi: 2
      Plants: 9
    rate_ratio: 0.0235
    p_value: 2.15e-07
    q_value: 9.12e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08171
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:28393888
      assigned_by: FlyBase
    - protein: UniProtKB:Q5F2F2
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000082644|SGD:S000000381|SGD:S000006016|UniProtKB:P08910
    - protein: UniProtKB:Q6UXT9
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000082644|SGD:S000000381|SGD:S000006016|UniProtKB:P08910
  - go_id: GO:0008881
    label: glutamate racemase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0235
    p_value: 2.15e-07
    q_value: 9.12e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D3Z0F6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1309192
    - protein: UniProtKB:Q8R238
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:5.1.1.3
    - protein: UniProtKB:Q8R238
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12813
    - protein: UniProtKB:Q8R238
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1309192
    - protein: UniProtKB:Q8R238
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0A6N3IN21
    - protein: UniProtKB:Q96GA7
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:5.1.1.3
    - protein: UniProtKB:Q96GA7
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12813
    - protein: UniProtKB:Q96GA7
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0A6N3IN21
  - go_id: GO:0016433
    label: rRNA (adenine) methyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 1
      Bacteria: 7
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0235
    p_value: 2.15e-07
    q_value: 9.12e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Z9V7
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9BVS5|ensembl:ENSP00000302801
    - protein: UniProtKB:Q7K2B0
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P38961
    - protein: UniProtKB:Q9BVS5
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:27631568
      assigned_by: UniProt
  - go_id: GO:0006487
    label: protein N-linked glycosylation
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 695
      Archaea: 7
      Bacteria: 3
      Fungi: 113
      Plants: 85
    rate_ratio: 0.0236
    p_value: 8.53e-33
    q_value: 1.88e-31
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZJZ3
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002249937
    - protein: UniProtKB:Q180C0
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001657990
    - protein: UniProtKB:Q18CK9
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001657971
  - go_id: GO:1904263
    label: positive regulation of TORC1 signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 479
      Archaea: 0
      Bacteria: 0
      Fungi: 35
      Plants: 3
    rate_ratio: 0.0237
    p_value: 4.56e-20
    q_value: 5.33e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RPE9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033247|PANTHER:PTN000111887|SGD:S000003068|UniProtKB:Q96EE3
    - protein: UniProtKB:D8SM57
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033247|PANTHER:PTN000111887|SGD:S000003068|UniProtKB:Q96EE3
    - protein: UniProtKB:Q93VR9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033247|PANTHER:PTN000111887|SGD:S000003068|UniProtKB:Q96EE3
  - go_id: GO:7770062
    label: vesicle membrane tethering activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 0
      Fungi: 35
      Plants: 3
    rate_ratio: 0.0237
    p_value: 4.56e-20
    q_value: 5.33e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HUA9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:42176019
      assigned_by: TAIR
    - protein: UniProtKB:F4K2W9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:42176019
      assigned_by: TAIR
    - protein: UniProtKB:Q9LVY8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:42176019
      assigned_by: TAIR
  - go_id: GO:0046487
    label: glyoxylate metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 13
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0239
    p_value: 1.61e-07
    q_value: 6.95e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FMN0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18687588
      assigned_by: TAIR
  - go_id: GO:0015970
    label: guanosine tetraphosphate biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 13
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0239
    p_value: 1.61e-07
    q_value: 6.95e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SYH1
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:26908759
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G14050,AGI_LocusCode:AT3G17470,AGI_LocusCode:AT4G02260
    - protein: UniProtKB:Q9SYH1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26908759
      assigned_by: TAIR
  - go_id: GO:0015269
    label: calcium-activated potassium channel activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 236
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.024
    p_value: 1.5e-15
    q_value: 1.29e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LBL1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:9184204
      assigned_by: TIGR
  - go_id: GO:2000637
    label: positive regulation of miRNA-mediated gene silencing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 232
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0244
    p_value: 2.83e-15
    q_value: 2.42e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L7S8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:40000658
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:2000637
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:2000637
  - go_id: GO:0032355
    label: response to estradiol
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 232
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0244
    p_value: 2.83e-15
    q_value: 2.42e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P06525
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:18441225
      assigned_by: UniProt
      gene_review: genes/ARATH/ADH1/ADH1-ai-review.yaml
  - go_id: GO:0051707
    label: response to other organism
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 291
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 132
    rate_ratio: 0.0244
    p_value: 2.06e-14
    q_value: 1.64e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39143
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029118
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0051707
  - go_id: GO:0015961
    label: diadenosine polyphosphate catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O95989
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:10419486
      assigned_by: PINC
  - go_id: GO:0015146
    label: pentose transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P13866
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:P11170
    - protein: UniProtKB:P53794
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:P31637
  - go_id: GO:0015750
    label: pentose transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P13866
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:P11170
    - protein: UniProtKB:P53794
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:P31637
  - go_id: GO:0032866
    label: D-xylose reductase (NADPH) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15121
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:27445
    - protein: UniProtKB:P45376
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:27445
  - go_id: GO:0016906
    label: sterol 3-beta-glucosyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 5
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P16662
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22724
  - go_id: GO:1903464
    label: negative regulation of mitotic cell cycle DNA replication
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P41182
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:10490843
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1903464
  - go_id: GO:0005527
    label: macrolide binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P54397
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086867
    - protein: UniProtKB:P62942
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:17962721
      assigned_by: BHF-UCL
  - go_id: GO:0000721
    label: (R,R)-butanediol dehydrogenase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q00796
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:3365415
      assigned_by: UniProt
    - protein: UniProtKB:Q00796
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.4
    - protein: UniProtKB:Q00796
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24340
    - protein: UniProtKB:Q64442
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q00796
  - go_id: GO:0005458
    label: GDP-mannose transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 3
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q24JQ0
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G13650|CGD:CAL0000182900|PANTHER:PTN000744836|PomBase:SPAC144.18|SGD:S000003193|UniProtKB:Q4WTQ6|UniProtKB:Q581R7|UniProtKB:Q9BIR6
    - protein: UniProtKB:Q3UME2
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G13650|CGD:CAL0000182900|PANTHER:PTN000744836|PomBase:SPAC144.18|SGD:S000003193|UniProtKB:Q4WTQ6|UniProtKB:Q581R7|UniProtKB:Q9BIR6
  - go_id: GO:1990570
    label: GDP-mannose transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 3
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q24JQ0
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G13650|CGD:CAL0000182900|PANTHER:PTN000744836|PomBase:SPAC144.18|SGD:S000003193|UniProtKB:Q4WTQ6|UniProtKB:Q84L09
    - protein: UniProtKB:Q3UME2
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G13650|CGD:CAL0000182900|PANTHER:PTN000744836|PomBase:SPAC144.18|SGD:S000003193|UniProtKB:Q4WTQ6|UniProtKB:Q84L09
  - go_id: GO:0089721
    label: phosphoenolpyruvate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3KQZ1
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q5SWT3|ensembl:ENSMUSP00000099666
    - protein: UniProtKB:Q3KQZ1
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q5SWT3
    - protein: UniProtKB:Q5SWT3
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:41850288
      assigned_by: UniProt
  - go_id: GO:0071264
    label: positive regulation of translational initiation in response to starvation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9P2K8
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9QZ05
      gene_review: genes/human/EIF2AK4/EIF2AK4-ai-review.yaml
    - protein: UniProtKB:Q9QZ05
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:10655230
      assigned_by: UniProt
    - protein: UniProtKB:Q9QZ05
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:16121183
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0071264
  - go_id: GO:2001040
    label: positive regulation of cellular response to drug
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9UMX1
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:A0A8I6A606|ensembl:ENSRNOP00000087532
      gene_review: genes/human/SUFU/SUFU-ai-review.yaml
    - protein: UniProtKB:Q9Z0P7
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:A0A8I6A606|ensembl:ENSRNOP00000087532
  - go_id: GO:0016074
    label: sno(s)RNA metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A140LIR6
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:14612397
      assigned_by: MGI
      with_from: MGI:MGI:3043754
    - protein: UniProtKB:P35550
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:14612397
      assigned_by: MGI
      with_from: MGI:MGI:3043754
  - go_id: GO:0044374
    label: sequence-specific DNA binding, bending
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P35710
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:8078769
      assigned_by: UniProt
  - go_id: GO:0061995
    label: ATP-dependent protein-DNA complex displacement activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q80W85
      taxon: NCBITaxon:10090
      evidence: TAS
      reference: Reactome:R-MMU-9822114
      assigned_by: Reactome
  - go_id: GO:0000740
    label: nuclear membrane fusion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P00356
      taxon: NCBITaxon:9031
      evidence: IMP
      reference: PMID:12651855
      assigned_by: AgBase
  - go_id: GO:0009202
    label: deoxyribonucleoside triphosphate biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08879
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:1320004
      assigned_by: UniProt
      gene_review: genes/DROME/awd__P08879/awd__P08879-ai-review.yaml
  - go_id: GO:1905866
    label: positive regulation of Atg1/ULK1 kinase complex assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P12370
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:29606597
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1905866
  - go_id: GO:0010777
    label: meiotic mismatch repair involved in reciprocal meiotic recombination
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q24595
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:25188408
      assigned_by: FlyBase
      with_from: FB:FBgn0036486
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0010777
  - go_id: GO:0031024
    label: interphase microtubule organizing center assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9I7U5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:23354166
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031024
  - go_id: GO:0070903
    label: mitochondrial tRNA thio-modification
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VKD3
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P25374
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070903
  - go_id: GO:0004780
    label: sulfate adenylyltransferase (ADP) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0244
    p_value: 0.000131
    q_value: 0.000372
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8FRQ0
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:19896942
      assigned_by: WB
    - protein: UniProtKB:G5EFS4
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:19896942
      assigned_by: WB
  - go_id: GO:0005780
    label: extrinsic component of intraperoxisomal membrane
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O44735
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024758
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0005780
  - go_id: GO:0090139
    label: mitochondrial chromosome packaging
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0244
    p_value: 0.0126
    q_value: 0.0238
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94234
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:21258070
      assigned_by: WB
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0090139
  - go_id: GO:1990477
    label: MTREC complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YAQ2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:O60293|ensembl:ENSP00000368017
    - protein: UniProtKB:F7A3J9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:O60293
    - protein: UniProtKB:O60293
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:27871484
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990477
  - go_id: GO:0032135
    label: DNA insertion or deletion binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 1
      Fungi: 6
      Plants: 8
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XSB3
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000145759|SGD:S000000688|UniProtKB:P20585
    - protein: UniProtKB:P13705
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000145759|SGD:S000000688|UniProtKB:P20585
    - protein: UniProtKB:P20585
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000145759|SGD:S000000688|UniProtKB:P20585
  - go_id: GO:1904931
    label: MCM complex binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KW09
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:31839537
      assigned_by: UniProt
    - protein: UniProtKB:Q8K203
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0A1L8HU22
    - protein: UniProtKB:Q8TAT5
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0A1L8HU22
  - go_id: GO:0010774
    label: meiotic strand invasion involved in reciprocal meiotic recombination
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 3
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZJB7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15|SGD:S000003001|SGD:S000003151
    - protein: UniProtKB:O35047
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15|SGD:S000003001|SGD:S000003151
    - protein: UniProtKB:Q9P2W1
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15|SGD:S000003001|SGD:S000003151
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0010774
  - go_id: GO:0030682
    label: symbiont-mediated perturbation of host defenses
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2ADZ6
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:28189564
      assigned_by: MGI
      with_from: MGI:MGI:3856636
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0030682
    - protein: UniProtKB:F8WHL4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:28189564
      assigned_by: MGI
      with_from: MGI:MGI:3856636
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0030682
    - protein: UniProtKB:O35345
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:28189564
      assigned_by: MGI
      with_from: MGI:MGI:3856636
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0030682
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:33090 (Viridiplantae), on GO:0030682
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0030682
    - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0030682
  - go_id: GO:0033768
    label: SUMO-targeted ubiquitin ligase complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4LHT4
      taxon: NCBITaxon:7227
      evidence: IC
      reference: PMID:21343912
      assigned_by: FlyBase
      with_from: GO:0032183,GO:0061630
    - protein: UniProtKB:Q8I0J6
      taxon: NCBITaxon:7227
      evidence: IC
      reference: PMID:21343912
      assigned_by: FlyBase
      with_from: GO:0032183,GO:0061630
    - protein: UniProtKB:Q9VNJ0
      taxon: NCBITaxon:7227
      evidence: IC
      reference: PMID:21343912
      assigned_by: FlyBase
      with_from: GO:0032183,GO:0061630
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0033768
  - go_id: GO:0032806
    label: carboxy-terminal domain protein kinase complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 0
    rate_ratio: 0.0244
    p_value: 1.52e-06
    q_value: 5.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z8B6
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:11447116
      assigned_by: FlyBase
    - protein: UniProtKB:O76513
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:11447116
      assigned_by: FlyBase
    - protein: UniProtKB:Q24216
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:11447116
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0032806
  - go_id: GO:0006565
    label: L-serine catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 43
      Archaea: 7
      Bacteria: 17
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0245
    p_value: 2.79e-07
    q_value: 1.16e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RYU7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00097959
    - protein: UniProtKB:D8SV17
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00097959
    - protein: UniProtKB:Q9MA74
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:39287621
      assigned_by: UniProt
    - protein: UniProtKB:Q9MA74
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00097959
  - go_id: GO:0003941
    label: L-serine ammonia-lyase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 39
      Archaea: 7
      Bacteria: 20
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0245
    p_value: 2.79e-07
    q_value: 1.16e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R3T5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G11640|MGI:MGI:1351636|PANTHER:PTN000034721|PomBase:SPCC320.14|UniProtKB:Q7XSN8|UniProtKB:Q9GZT4|dictyBase:DDB_G0289463
    - protein: UniProtKB:D8R3T5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00088741
    - protein: UniProtKB:D8SIH3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G11640|MGI:MGI:1351636|PANTHER:PTN000034721|PomBase:SPCC320.14|UniProtKB:Q7XSN8|UniProtKB:Q9GZT4|dictyBase:DDB_G0289463
    - protein: UniProtKB:D8SIH3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00088741
    - protein: UniProtKB:Q2PGG3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G11640|MGI:MGI:1351636|PANTHER:PTN000034721|PomBase:SPCC320.14|UniProtKB:Q7XSN8|UniProtKB:Q9GZT4|dictyBase:DDB_G0289463
    - protein: UniProtKB:Q2PGG3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16483618
      assigned_by: UniProt
    - protein: UniProtKB:Q2PGG3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.1.17
    - protein: UniProtKB:Q2PGG3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:19169
    - protein: UniProtKB:Q2PGG3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00088741
  - go_id: GO:0004794
    label: threonine deaminase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 47
      Archaea: 7
      Bacteria: 9
      Fungi: 6
      Plants: 3
    rate_ratio: 0.0245
    p_value: 2.79e-07
    q_value: 1.16e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QMP7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G10050|PANTHER:PTN002459384|PomBase:SPBC1677.03c|RGD:1309192|RGD:67376|SGD:S000000569|SGD:S000000888|UniProtKB:A0FKE6|UniProtKB:P04968|UniProtKB:P0AGF6|UniProtKB:P20132|UniProtKB:P25306|UniProtKB:Q74FW6|UniProtKB:Q96GA7|UniProtKB:Q9WYJ1
    - protein: UniProtKB:D8QMP7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005787
    - protein: UniProtKB:D8QMP7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.1.19|EC:4.3.1.19
    - protein: UniProtKB:D8QMP7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000129796
    - protein: UniProtKB:D8QMP7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22108
    - protein: UniProtKB:D8QMP7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026250
    - protein: UniProtKB:D8R7H6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G10050|PANTHER:PTN002459384|PomBase:SPBC1677.03c|RGD:1309192|RGD:67376|SGD:S000000569|SGD:S000000888|UniProtKB:A0FKE6|UniProtKB:P04968|UniProtKB:P0AGF6|UniProtKB:P20132|UniProtKB:P25306|UniProtKB:Q74FW6|UniProtKB:Q96GA7|UniProtKB:Q9WYJ1
    - protein: UniProtKB:D8R7H6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005787
    - protein: UniProtKB:D8R7H6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.1.19|EC:4.3.1.19
    - protein: UniProtKB:D8R7H6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000129796
    - protein: UniProtKB:D8R7H6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22108
    - protein: UniProtKB:D8R7H6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026250
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G10050|PANTHER:PTN002459384|PomBase:SPBC1677.03c|RGD:1309192|RGD:67376|SGD:S000000569|SGD:S000000888|UniProtKB:A0FKE6|UniProtKB:P04968|UniProtKB:P0AGF6|UniProtKB:P20132|UniProtKB:P25306|UniProtKB:Q74FW6|UniProtKB:Q96GA7|UniProtKB:Q9WYJ1
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28522547
      assigned_by: TAIR
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005787
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.1.19
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22108
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026250
    - protein: UniProtKB:Q9ZSS6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:12228340
      assigned_by: TAIR
  - go_id: GO:0000107
    label: imidazoleglycerol-phosphate synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 7
      Bacteria: 10
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0245
    p_value: 2.79e-07
    q_value: 1.16e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RBX3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000477998|SGD:S000000452|UniProtKB:P60664
    - protein: UniProtKB:D8RBX3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004651|InterPro:IPR014640
    - protein: UniProtKB:D8RXQ1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000477998|SGD:S000000452|UniProtKB:P60664
    - protein: UniProtKB:D8RXQ1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004651|InterPro:IPR014640
    - protein: UniProtKB:Q9SZ30
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000477998|SGD:S000000452|UniProtKB:P60664
    - protein: UniProtKB:Q9SZ30
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004651|InterPro:IPR014640
    - protein: UniProtKB:Q9SZ30
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24793
  - go_id: GO:0044325
    label: transmembrane transporter binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 833
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0246
    p_value: 4.43e-16
    q_value: 3.99e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q06671
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:42477132
      assigned_by: SGD
      with_from: SGD:S000002308
  - go_id: GO:0002682
    label: regulation of immune system process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 230
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0246
    p_value: 3.89e-15
    q_value: 3.29e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8AXJ0
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027003
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0002682
  - go_id: GO:0071456
    label: cellular response to hypoxia
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 546
      Archaea: 0
      Bacteria: 2
      Fungi: 10
      Plants: 262
    rate_ratio: 0.0246
    p_value: 6.97e-28
    q_value: 1.22e-26
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZL10
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002293253
    - protein: UniProtKB:A5A618
      taxon: NCBITaxon:83333
      evidence: IEP
      reference: PMID:19734316
      assigned_by: EcoCyc
  - go_id: GO:0042597
    label: periplasmic space
    aspect: CC
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 442
      Fungi: 11
      Plants: 0
    rate_ratio: 0.0246
    p_value: 1.86e-29
    q_value: 3.49e-28
    flagged_in_2019_or_2018: true
    flagged_annotations:
    - protein: UniProtKB:Q6LXT7
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0200
    - protein: UniProtKB:Q6LYJ4
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0200
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2 or NCBITaxon:2157 or NCBITaxon:4751 (Fungi or Bacteria or Archaea), on
      GO:0042597
  - go_id: GO:0042391
    label: regulation of membrane potential
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 687
      Archaea: 0
      Bacteria: 1
      Fungi: 10
      Plants: 3
    rate_ratio: 0.0247
    p_value: 1.01e-43
    q_value: 3.17e-42
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QXY5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1918781|MGI:MGI:3603204|PANTHER:PTN000323131
    - protein: UniProtKB:D8RUP6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1918781|MGI:MGI:3603204|PANTHER:PTN000323131
    - protein: UniProtKB:Q38898
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:12172027
      assigned_by: TAIR
  - go_id: GO:0005876
    label: spindle microtubule
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 294
      Archaea: 0
      Bacteria: 1
      Fungi: 36
      Plants: 35
    rate_ratio: 0.0247
    p_value: 6.76e-11
    q_value: 4.13e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q189D3
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000649234
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005876
  - go_id: GO:0001778
    label: plasma membrane repair
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 227
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0249
    p_value: 6.25e-15
    q_value: 5.21e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SKR2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19088329
      assigned_by: TAIR
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0001778
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0001778
  - go_id: GO:0006888
    label: endoplasmic reticulum to Golgi vesicle-mediated transport
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1377
      Archaea: 1
      Bacteria: 0
      Fungi: 193
      Plants: 163
    rate_ratio: 0.0251
    p_value: 1.22e-14
    q_value: 9.98e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4J6E6
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000432562
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006888
  - go_id: GO:0030867
    label: rough endoplasmic reticulum membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 85
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 1
    rate_ratio: 0.0251
    p_value: 9.41e-07
    q_value: 3.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94BX4
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P37287
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0030867
  - go_id: GO:0071030
    label: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 8
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 1
    rate_ratio: 0.0251
    p_value: 9.41e-07
    q_value: 3.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O23676
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000290902|PomBase:SPBC3B9.08c
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071030
  - go_id: GO:0000372
    label: Group I intron splicing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 11
      Plants: 1
    rate_ratio: 0.0251
    p_value: 9.41e-07
    q_value: 3.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L7C2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18065687
      assigned_by: TAIR
  - go_id: GO:0043224
    label: nuclear SCF ubiquitin ligase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 1
    rate_ratio: 0.0251
    p_value: 9.41e-07
    q_value: 3.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZR12
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15992545
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0043224
  - go_id: GO:0043617
    label: cellular response to sucrose starvation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 7
    rate_ratio: 0.0253
    p_value: 2.4e-05
    q_value: 7.65e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VVK5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:20940317
      assigned_by: FlyBase
  - go_id: GO:0008361
    label: regulation of cell size
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 117
      Archaea: 0
      Bacteria: 1
      Fungi: 35
      Plants: 25
    rate_ratio: 0.0254
    p_value: 1.4e-10
    q_value: 8.29e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P62517
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:23935518
      assigned_by: EcoCyc
      gene_review: genes/ECOLI/opgH/opgH-ai-review.yaml
  - go_id: GO:0005216
    label: monoatomic ion channel activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 2376
      Archaea: 0
      Bacteria: 10
      Fungi: 3
      Plants: 74
    rate_ratio: 0.0258
    p_value: 2.83e-44
    q_value: 9.11e-43
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O14234
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005821
    - protein: UniProtKB:P50077
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005821
    - protein: UniProtKB:Q5A936
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005821
  - go_id: GO:0009264
    label: deoxyribonucleotide catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 48
      Archaea: 1
      Bacteria: 12
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0259
    p_value: 6.34e-07
    q_value: 2.53e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JVY6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010708
  - go_id: GO:0003908
    label: methylated-DNA-[protein]-cysteine S-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 12
      Archaea: 2
      Bacteria: 12
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0259
    p_value: 6.34e-07
    q_value: 2.53e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I209
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33615694
      assigned_by: TAIR
  - go_id: GO:0019854
    label: L-ascorbic acid catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 12
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0259
    p_value: 6.34e-07
    q_value: 2.53e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LPL3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00263
  - go_id: GO:0042178
    label: xenobiotic catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 218
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0259
    p_value: 2.6e-14
    q_value: 2.06e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9M156
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:12753587
      assigned_by: TAIR
  - go_id: GO:0051607
    label: defense response to virus
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 777
      Archaea: 5
      Bacteria: 14
      Fungi: 1
      Plants: 77
    rate_ratio: 0.0263
    p_value: 5.99e-15
    q_value: 4.99e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08466
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:31266891
      assigned_by: SGD
      gene_review: genes/yeast/NUC1/NUC1-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0051607
  - go_id: GO:0015220
    label: choline transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 213
      Archaea: 0
      Bacteria: 7
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0266
    p_value: 5.74e-14
    q_value: 4.44e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AN2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25008948
      assigned_by: TAIR
  - go_id: GO:0140378
    label: protein complex scaffold activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 187
      Archaea: 0
      Bacteria: 2
      Fungi: 67
      Plants: 63
    rate_ratio: 0.0266
    p_value: 1.65e-19
    q_value: 1.87e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P62672
      taxon: NCBITaxon:83333
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002682344|UniProtKB:Q9Y2S7
    - protein: UniProtKB:Q56017
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002682344|UniProtKB:Q9Y2S7
  - go_id: GO:0015344
    label: siderophore uptake transmembrane transporter activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 42
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0267
    p_value: 1.01e-10
    q_value: 6.09e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39980
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:9884238
      assigned_by: SGD
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0015344
  - go_id: GO:0050829
    label: defense response to Gram-negative bacterium
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 670
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 23
    rate_ratio: 0.0272
    p_value: 2.04e-14
    q_value: 1.63e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZG14
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000293
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0050829
  - go_id: GO:0009855
    label: determination of bilateral symmetry
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 13
    rate_ratio: 0.0272
    p_value: 3.09e-09
    q_value: 1.61e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0ACM8PYB6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22556250
      assigned_by: FlyBase
    - protein: UniProtKB:Q62148
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:15731404
      assigned_by: MGI
      with_from: MGI:MGI:1857891
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0009855
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0009855
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0009855
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0009855
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0009855
  - go_id: GO:0016174
    label: NAD(P)H oxidase H2O2-forming activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 98
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 133
    rate_ratio: 0.0272
    p_value: 4.83e-13
    q_value: 3.54e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P38169
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:23575632
      assigned_by: UniProt
      gene_review: genes/yeast/BNA4/BNA4-ai-review.yaml
    - protein: UniProtKB:P38169
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:29429898
      assigned_by: UniProt
      gene_review: genes/yeast/BNA4/BNA4-ai-review.yaml
  - go_id: GO:0045148
    label: tripeptide aminopeptidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0274
    p_value: 0.000202
    q_value: 0.000558
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09960
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:11675384
      assigned_by: UniProt
    - protein: UniProtKB:P09960
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:11917124
      assigned_by: UniProt
    - protein: UniProtKB:P09960
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:20813919
      assigned_by: UniProt
    - protein: UniProtKB:P09960
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:24591641
      assigned_by: UniProt
    - protein: UniProtKB:P09960
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:9395533
      assigned_by: UniProt
    - protein: UniProtKB:P09960
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.4.11.4
    - protein: UniProtKB:P24527
      taxon: NCBITaxon:10090
      evidence: EXP
      reference: PMID:1881903
      assigned_by: UniProt
    - protein: UniProtKB:P24527
      taxon: NCBITaxon:10090
      evidence: EXP
      reference: PMID:20813919
      assigned_by: UniProt
    - protein: UniProtKB:P24527
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.4.11.4
    - protein: UniProtKB:P24527
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P09960
  - go_id: GO:0015138
    label: fumarate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0274
    p_value: 2.9e-06
    q_value: 1.06e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AM47
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008496849|RGD:61920|UniProtKB:Q13183
    - protein: UniProtKB:A0A8V1AM47
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q13183|ensembl:ENSP00000316202
    - protein: UniProtKB:Q13183
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008496849|RGD:61920|UniProtKB:Q13183
    - protein: UniProtKB:Q13183
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:10894787
      assigned_by: UniProt
    - protein: UniProtKB:Q13183
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P70545|ensembl:ENSRNOP00000038185
    - protein: UniProtKB:Q9ES88
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008496849|RGD:61920|UniProtKB:Q13183
    - protein: UniProtKB:Q9ES88
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P70545|ensembl:ENSRNOP00000038185
    - protein: UniProtKB:Q9ES88
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q13183|ensembl:ENSP00000316202
    - protein: UniProtKB:Q9ES88
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:61920
    - protein: UniProtKB:Q9ES88
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q13183
    - protein: UniProtKB:Q9ES88
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q13183
  - go_id: GO:0032329
    label: serine transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0274
    p_value: 2.9e-06
    q_value: 1.06e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2ALH6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q8WUX1
    - protein: UniProtKB:Q3U1J0
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002741896|RGD:620702|UniProtKB:Q8WUX1
    - protein: UniProtKB:Q3U1J0
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8WUX1|ensembl:ENSP00000481291
    - protein: UniProtKB:Q3U1J0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q8WUX1
    - protein: UniProtKB:Q8WUX1
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002741896|RGD:620702|UniProtKB:Q8WUX1
    - protein: UniProtKB:Q8WUX1
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:11243884
      assigned_by: ARUK-UCL
  - go_id: GO:0051595
    label: response to methylglyoxal
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0274
    p_value: 2.9e-06
    q_value: 1.06e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E9PXF9
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:17670746
      assigned_by: MGI
    - protein: UniProtKB:E9Q2L1
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:17670746
      assigned_by: MGI
    - protein: UniProtKB:Q60520
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:17670746
      assigned_by: MGI
  - go_id: GO:0008300
    label: isoprenoid catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O09174
      taxon: NCBITaxon:10090
      evidence: TAS
      reference: PMID:11060344
      assigned_by: MGI
  - go_id: GO:0051997
    label: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q283N4
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:3647519|PANTHER:PTN000044713|ZFIN:ZDB-GENE-070112-472
    - protein: UniProtKB:Q283N4
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:16462750
      assigned_by: MGI
    - protein: UniProtKB:Q283N4
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.1.1.97
    - protein: UniProtKB:Q283N4
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:26301
    - protein: UniProtKB:Q283N4
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089513
  - go_id: GO:0019402
    label: galactitol metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9R0N0
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10915771
      assigned_by: MGI
      with_from: MGI:MGI:2148688
  - go_id: GO:0070406
    label: L-glutamine binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P05990
      taxon: NCBITaxon:7227
      evidence: IC
      reference: DOI:10.1016/0020-1790(79)90006-4
      assigned_by: FlyBase
      with_from: GO:0004088
  - go_id: GO:0140696
    label: (S)-2-hydroxyglutarate dehydrogenase (quinone) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VJ28
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:42203459
      assigned_by: FlyBase
  - go_id: GO:0034639
    label: L-amino acid efflux transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09500
      taxon: NCBITaxon:6239
      evidence: IC
      reference: PMID:22822152
      assigned_by: WB
      with_from: GO:0015811
  - go_id: GO:0016782
    label: transferase activity, transferring sulphur-containing groups
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0274
    p_value: 0.0157
    q_value: 0.0288
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q19434
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026283
  - go_id: GO:0140597
    label: protein carrier activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 189
      Archaea: 0
      Bacteria: 0
      Fungi: 30
      Plants: 3
    rate_ratio: 0.0276
    p_value: 6.22e-17
    q_value: 5.96e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RF76
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000305707|SGD:S000005690|UniProtKB:Q7L5D6
    - protein: UniProtKB:D8SDD1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000305707|SGD:S000005690|UniProtKB:Q7L5D6
    - protein: UniProtKB:Q6GKV1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000305707|SGD:S000005690|UniProtKB:Q7L5D6
  - go_id: GO:0090554
    label: phosphatidylcholine floppase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 49
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 1
    rate_ratio: 0.0276
    p_value: 3.99e-06
    q_value: 1.42e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LI83
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26212235
      assigned_by: TAIR
  - go_id: GO:0000346
    label: transcription export complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 86
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 1
    rate_ratio: 0.0276
    p_value: 3.99e-06
    q_value: 1.42e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L4M1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002547886|UniProtKB:Q86W42
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000346
  - go_id: GO:0071629
    label: cytoplasm protein quality control by the ubiquitin-proteasome system
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 16
      Archaea: 0
      Bacteria: 0
      Fungi: 20
      Plants: 2
    rate_ratio: 0.0276
    p_value: 1.49e-11
    q_value: 9.61e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0WUQ1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27343446
      assigned_by: TAIR
    - protein: UniProtKB:Q9LQX2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:29087340
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071629
  - go_id: GO:1990578
    label: perinuclear endoplasmic reticulum membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 17
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 1
    rate_ratio: 0.0276
    p_value: 3.99e-06
    q_value: 1.42e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VXU6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16786289
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990578
  - go_id: GO:0001002
    label: RNA polymerase III type 1 promoter sequence-specific DNA binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 12
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 1
    rate_ratio: 0.0276
    p_value: 3.99e-06
    q_value: 1.42e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HP69
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001430930|SGD:S000002770
  - go_id: GO:0015194
    label: L-serine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 5
      Fungi: 10
      Plants: 1
    rate_ratio: 0.0276
    p_value: 3.99e-06
    q_value: 1.42e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q42400
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25005136
      assigned_by: TAIR
  - go_id: GO:0006673
    label: inositol phosphoceramide metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 1
    rate_ratio: 0.0276
    p_value: 3.99e-06
    q_value: 1.42e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GWB7
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27643972
      assigned_by: UniProt
  - go_id: GO:0005178
    label: integrin binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 736
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0278
    p_value: 4.01e-14
    q_value: 3.15e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P87020
      taxon: NCBITaxon:237561
      evidence: IDA
      reference: PMID:17277107
      assigned_by: CGD
  - go_id: GO:0031398
    label: positive regulation of protein ubiquitination
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 404
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.028
    p_value: 1.04e-25
    q_value: 1.64e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4K4R1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000497925|UniProtKB:A0A8V0YNA7|UniProtKB:Q9NVI1
    - protein: UniProtKB:Q9C901
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:35524486
      assigned_by: TAIR
  - go_id: GO:0070328
    label: triglyceride homeostasis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 202
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.028
    p_value: 3.27e-13
    q_value: 2.43e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22975
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20876112
      assigned_by: TAIR
  - go_id: GO:0004867
    label: serine-type endopeptidase inhibitor activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1941
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 44
    rate_ratio: 0.0282
    p_value: 3.27e-40
    q_value: 9.15e-39
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P23827
      taxon: NCBITaxon:83333
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002185576|UniProtKB:P23827
    - protein: UniProtKB:P23827
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:35483450
      assigned_by: UniProt
    - protein: UniProtKB:P23827
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:6411724
      assigned_by: EcoCyc
    - protein: UniProtKB:P23827
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005658|InterPro:IPR023084
    - protein: UniProtKB:P23827
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000098374
    - protein: UniProtKB:Q02NQ8
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005658|InterPro:IPR023084
    - protein: UniProtKB:Q02NQ8
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000098374
    - protein: UniProtKB:Q8ZNH4
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002185576|UniProtKB:P23827
    - protein: UniProtKB:Q8ZNH4
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005658|InterPro:IPR023084
    - protein: UniProtKB:Q8ZNH4
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000098374
  - go_id: GO:0019897
    label: extrinsic component of plasma membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 44
      Archaea: 0
      Bacteria: 11
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0282
    p_value: 2.47e-06
    q_value: 9.14e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GYN5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22215637
      assigned_by: TAIR
  - go_id: GO:0015752
    label: D-ribose transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 11
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0282
    p_value: 2.47e-06
    q_value: 9.14e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VZ80
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015591
  - go_id: GO:0009617
    label: response to bacterium
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 555
      Archaea: 0
      Bacteria: 2
      Fungi: 3
      Plants: 227
    rate_ratio: 0.0284
    p_value: 6.76e-24
    q_value: 9.71e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z852
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003060
    - protein: UniProtKB:A0A0H2ZF46
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003060
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0009617
  - go_id: GO:0033993
    label: response to lipid
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 77
      Archaea: 2
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SX49
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028073
  - go_id: GO:0050201
    label: fucokinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 20
      Archaea: 2
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LNJ9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G01220|MGI:MGI:1916071|PANTHER:PTN000794963|UniProtKB:Q4QEX2|UniProtKB:Q4QEX6|UniProtKB:Q8N0W3
    - protein: UniProtKB:Q9LNJ9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18199744
      assigned_by: TAIR
    - protein: UniProtKB:Q9LNJ9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.52
    - protein: UniProtKB:Q9LNJ9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13241
  - go_id: GO:0042352
    label: GDP-L-fucose salvage
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 35
      Archaea: 2
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LNJ9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G01220|MGI:MGI:1916071|PANTHER:PTN000794963|UniProtKB:Q8N0W3
    - protein: UniProtKB:Q9LNJ9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18199744
      assigned_by: TAIR
  - go_id: GO:1902603
    label: carnitine transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 33
      Archaea: 2
      Bacteria: 9
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9CAT6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015226
  - go_id: GO:0015226
    label: carnitine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 24
      Archaea: 2
      Bacteria: 8
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9CAT6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17521409
      assigned_by: TAIR
  - go_id: GO:0035444
    label: nickel cation transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 11
      Archaea: 2
      Bacteria: 10
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KGN5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16790430
      assigned_by: UniProt
  - go_id: GO:1903457
    label: lactate catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 6
      Archaea: 2
      Bacteria: 8
      Fungi: 6
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AX4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000202298|SGD:S000002333|UniProtKB:Q86WU2|ZFIN:ZDB-GENE-030131-6140
  - go_id: GO:0000041
    label: transition metal ion transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 17
      Archaea: 2
      Bacteria: 4
      Fungi: 9
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KGN5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16790430
      assigned_by: TAIR
  - go_id: GO:0008710
    label: 8-amino-7-oxononanoate synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 6
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GW43
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.1.47
  - go_id: GO:0141093
    label: 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RBF3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.5.1.147|EC:2.5.1.147
  - go_id: GO:0052684
    label: L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0286
    p_value: 0.0169
    q_value: 0.0308
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FFW8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:20701934
      assigned_by: TAIR
  - go_id: GO:0034087
    label: establishment of mitotic sister chromatid cohesion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 0
      Fungi: 29
      Plants: 3
    rate_ratio: 0.0286
    p_value: 2.62e-16
    q_value: 2.4e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A5HEI1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000496017|SGD:S000002588
    - protein: UniProtKB:D8RFB7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000496017|SGD:S000002588
    - protein: UniProtKB:D8SDH0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000496017|SGD:S000002588
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0034087
  - go_id: GO:0019900
    label: kinase binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 715
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 82
    rate_ratio: 0.0286
    p_value: 1.06e-13
    q_value: 8.08e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P32917
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR021651
      gene_review: genes/yeast/STE5/STE5-ai-review.yaml
  - go_id: GO:0007004
    label: telomere maintenance via telomerase
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 182
      Archaea: 0
      Bacteria: 1
      Fungi: 31
      Plants: 32
    rate_ratio: 0.0287
    p_value: 2.53e-09
    q_value: 1.34e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZAI7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN007664302
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0007004
  - go_id: GO:0033209
    label: tumor necrosis factor-mediated signaling pathway
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 389
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0291
    p_value: 1.11e-24
    q_value: 1.64e-23
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R5K7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002313819|UniProtKB:Q86VX2
    - protein: UniProtKB:D8SFE0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002313819|UniProtKB:Q86VX2
  - go_id: GO:0044615
    label: nuclear pore nuclear basket
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 74
      Archaea: 0
      Bacteria: 0
      Fungi: 19
      Plants: 2
    rate_ratio: 0.0291
    p_value: 6.25e-11
    q_value: 3.83e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JPS3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:41206590
      assigned_by: TAIR
    - protein: UniProtKB:O04326
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000488224|SGD:S000004762
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0044615
  - go_id: GO:0140401
    label: 4-phosphoerythronate phosphatase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.0293
    p_value: 2.18e-05
    q_value: 6.99e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A6NDG6
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:86555
    - protein: UniProtKB:Q5F4B1
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:86555
    - protein: UniProtKB:Q8CHP8
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:86555
  - go_id: GO:0044774
    label: mitotic DNA integrity checkpoint signaling
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.0293
    p_value: 2.18e-05
    q_value: 6.99e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0N4SVW0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q53H47
    - protein: UniProtKB:Q53H47
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002917896|UniProtKB:Q53H47
    - protein: UniProtKB:Q53H47
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:18790802
      assigned_by: UniProt
    - protein: UniProtKB:Q80UJ9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q53H47
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0044774
  - go_id: GO:0051728
    label: cell cycle switching, mitotic to meiotic cell cycle
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.0293
    p_value: 2.18e-05
    q_value: 6.99e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YQQ0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P86049|ensembl:ENSMUSP00000045511
    - protein: UniProtKB:P86049
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:36001654
      assigned_by: UniProt
    - protein: UniProtKB:Q8TBY0
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P86049|ensembl:ENSMUSP00000045511
    - protein: UniProtKB:Q8TBY0
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P86049
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051728
  - go_id: GO:0120231
    label: DNA recombinase auxiliary factor complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0293
    p_value: 2.18e-05
    q_value: 6.99e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZJB7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15|SGD:S000003001|SGD:S000003151
    - protein: UniProtKB:O35047
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15|SGD:S000003001|SGD:S000003151
    - protein: UniProtKB:Q9P2W1
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409077|PomBase:SPAC222.15|SGD:S000003001|SGD:S000003151
  - go_id: GO:0052574
    label: UDP-galactose biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 0
    rate_ratio: 0.0293
    p_value: 2.18e-05
    q_value: 6.99e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E2QCV4
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:27562100
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VMA2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:27562100
      assigned_by: FlyBase
    - protein: UniProtKB:Q9W0P5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:20519568
      assigned_by: FlyBase
    - protein: UniProtKB:Q9W0P5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22654673
      assigned_by: FlyBase
  - go_id: GO:0008901
    label: ferredoxin hydrogenase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 7
      Bacteria: 16
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0295
    p_value: 5.88e-05
    q_value: 0.000178
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9Y7N7
      taxon: NCBITaxon:284812
      evidence: ISM
      reference: GO_REF:0000050
      assigned_by: PomBase
      with_from: Pfam:PF02906
  - go_id: GO:0048041
    label: focal adhesion assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 191
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0296
    p_value: 1.86e-12
    q_value: 1.3e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LSR8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16361528
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0048041
  - go_id: GO:0032418
    label: lysosome localization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 191
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0296
    p_value: 1.86e-12
    q_value: 1.3e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J1T2
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000337884|UniProtKB:Q9BQD3
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0032418
  - go_id: GO:0140677
    label: molecular function activator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 190
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0298
    p_value: 2.18e-12
    q_value: 1.52e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O23661
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:30202032
      assigned_by: DisProt
      with_from: UniProtKB:O81313
  - go_id: GO:0008138
    label: protein tyrosine/serine/threonine phosphatase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1220
      Archaea: 0
      Bacteria: 2
      Fungi: 15
      Plants: 61
    rate_ratio: 0.0299
    p_value: 2.05e-25
    q_value: 3.18e-24
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P55798
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:9130712
      assigned_by: EcoCyc
    - protein: UniProtKB:P55799
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:9130712
      assigned_by: EcoCyc
  - go_id: GO:0004650
    label: polygalacturonase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 121
    rate_ratio: 0.0299
    p_value: 8.24e-12
    q_value: 5.44e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001275777|SGD:S000003914|UniProtKB:Q5ATQ3|UniProtKB:Q5B508
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:10650215
      assigned_by: SGD
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000743
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.2.1.15
    - protein: UniProtKB:P47180
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027055
  - go_id: GO:0009636
    label: response to toxic substance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 297
      Archaea: 2
      Bacteria: 31
      Fungi: 10
      Plants: 3
    rate_ratio: 0.03
    p_value: 2.23e-16
    q_value: 2.05e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C5U2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17216481
      assigned_by: UniProt
      gene_review: genes/ARATH/AHK2/AHK2-ai-review.yaml
    - protein: UniProtKB:Q9LUH2
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:11449055
      assigned_by: TAIR
    - protein: UniProtKB:Q9M156
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:12753587
      assigned_by: TAIR
  - go_id: GO:0022604
    label: regulation of cell morphogenesis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 188
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0301
    p_value: 2.98e-12
    q_value: 2.05e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I9A2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:28399805
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0022604
  - go_id: GO:0035019
    label: somatic stem cell population maintenance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 188
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0301
    p_value: 2.98e-12
    q_value: 2.05e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XGW1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18653559
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0035019
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0035019
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0035019
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0035019
  - go_id: GO:0030247
    label: polysaccharide binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 98
      Archaea: 0
      Bacteria: 1
      Fungi: 1
      Plants: 106
    rate_ratio: 0.0304
    p_value: 1.88e-11
    q_value: 1.2e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P27835
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:16199561
      assigned_by: EcoCyc
  - go_id: GO:0051721
    label: protein phosphatase 2A binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 186
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0304
    p_value: 4.09e-12
    q_value: 2.78e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q941D6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22404109
      assigned_by: TAIR
  - go_id: GO:0050545
    label: sulfopyruvate decarboxylase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 6
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0307
    p_value: 0.000171
    q_value: 0.000477
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O06738
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002203706|UniProtKB:Q58540
  - go_id: GO:0045275
    label: respiratory chain complex III
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 208
      Archaea: 0
      Bacteria: 1
      Fungi: 29
      Plants: 29
    rate_ratio: 0.0307
    p_value: 1.07e-08
    q_value: 5.25e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZGY7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR030689
  - go_id: GO:0006688
    label: glycosphingolipid biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 112
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 1
    rate_ratio: 0.0307
    p_value: 1.68e-05
    q_value: 5.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LY62
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27895225
      assigned_by: UniProt
  - go_id: GO:1904408
    label: melatonin binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 10
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 1
    rate_ratio: 0.0307
    p_value: 1.68e-05
    q_value: 5.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AH1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29702752
      assigned_by: UniProt
  - go_id: GO:0043291
    label: RAVE complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 14
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 1
    rate_ratio: 0.0307
    p_value: 1.68e-05
    q_value: 5.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IJ68
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000359150|PomBase:SPBC1105.10|SGD:S000003794
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0043291
  - go_id: GO:0019740
    label: nitrogen utilization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 12
      Fungi: 18
      Plants: 2
    rate_ratio: 0.0307
    p_value: 2.62e-10
    q_value: 1.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q43314
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:8643469
      assigned_by: TAIR
    - protein: UniProtKB:Q8L8Y3
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:24179095
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0019740
  - go_id: GO:0140588
    label: chromatin looping
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 77
      Archaea: 0
      Bacteria: 0
      Fungi: 27
      Plants: 3
    rate_ratio: 0.0307
    p_value: 4.58e-15
    q_value: 3.85e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A5HEI1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033031
    - protein: UniProtKB:D8RFB7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033031
    - protein: UniProtKB:D8SDH0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033031
  - go_id: GO:0030155
    label: regulation of cell adhesion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 367
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0308
    p_value: 3.56e-23
    q_value: 4.91e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q42371
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16007076
      assigned_by: TAIR
      gene_review: genes/ARATH/ERECTA/ERECTA-ai-review.yaml
    - protein: UniProtKB:Q9LFC0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2144842|PANTHER:PTN000336748
  - go_id: GO:0035351
    label: heme transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 25
      Archaea: 0
      Bacteria: 10
      Fungi: 2
      Plants: 1
    rate_ratio: 0.031
    p_value: 9.6e-06
    q_value: 3.24e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C8T1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015439
  - go_id: GO:0015755
    label: fructose transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 41
      Archaea: 0
      Bacteria: 20
      Fungi: 17
      Plants: 2
    rate_ratio: 0.031
    p_value: 8.56e-11
    q_value: 5.18e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84WN3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24381066
      assigned_by: UniProt
    - protein: UniProtKB:Q8L6Z8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17284600
      assigned_by: TAIR
  - go_id: GO:1901264
    label: carbohydrate derivative transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 20
      Fungi: 1
      Plants: 2
    rate_ratio: 0.031
    p_value: 8.56e-11
    q_value: 5.18e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RD67
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005338
    - protein: UniProtKB:D8RFA2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005338
  - go_id: GO:0071281
    label: cellular response to iron ion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 41
      Archaea: 0
      Bacteria: 20
      Fungi: 9
      Plants: 2
    rate_ratio: 0.031
    p_value: 8.56e-11
    q_value: 5.18e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96262
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:17264065
      assigned_by: UniProt
    - protein: UniProtKB:Q9SZ46
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:21315474
      assigned_by: TAIR
  - go_id: GO:0036104
    label: Kdo2-lipid A biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 10
      Fungi: 0
      Plants: 1
    rate_ratio: 0.031
    p_value: 9.6e-06
    q_value: 3.24e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VZA5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00360
      gene_review: genes/ARATH/KDTA/KDTA-ai-review.yaml
  - go_id: GO:0050850
    label: positive regulation of calcium-mediated signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 182
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0311
    p_value: 7.67e-12
    q_value: 5.09e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I5N6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15824136
      assigned_by: TAIR
  - go_id: GO:0010467
    label: gene expression
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1731
      Archaea: 2
      Bacteria: 3
      Fungi: 16
      Plants: 46
    rate_ratio: 0.0316
    p_value: 1.73e-35
    q_value: 4.18e-34
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZI69
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028330
    - protein: UniProtKB:P08821
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028330
    - protein: UniProtKB:P68573
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028330
  - go_id: GO:0005884
    label: actin filament
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 577
      Archaea: 0
      Bacteria: 1
      Fungi: 23
      Plants: 19
    rate_ratio: 0.0316
    p_value: 2.54e-12
    q_value: 1.76e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZE15
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002904484
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005884
  - go_id: GO:0048306
    label: calcium-dependent protein binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 358
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0316
    p_value: 1.47e-22
    q_value: 1.96e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RL71
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN007521306|RGD:3245|RGD:3614|UniProtKB:P04271|UniProtKB:P06703|UniProtKB:P25815|UniProtKB:P31949|UniProtKB:Q98953
    - protein: UniProtKB:Q9XIR0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN007521306|RGD:3245|RGD:3614|UniProtKB:P04271|UniProtKB:P06703|UniProtKB:P25815|UniProtKB:P31949|UniProtKB:Q98953
  - go_id: GO:0000156
    label: phosphorelay response regulator activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 172
      Fungi: 8
      Plants: 25
    rate_ratio: 0.0316
    p_value: 1.35e-11
    q_value: 8.71e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P62647
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000673|InterPro:IPR008248
  - go_id: GO:0043539
    label: protein serine/threonine kinase activator activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 439
      Archaea: 0
      Bacteria: 1
      Fungi: 28
      Plants: 40
    rate_ratio: 0.0318
    p_value: 2.2e-08
    q_value: 1.04e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0CI74
      taxon: NCBITaxon:224308
      evidence: IDA
      reference: PMID:25845974
      assigned_by: UniProt
  - go_id: GO:0006886
    label: intracellular protein transport
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3723
      Archaea: 2
      Bacteria: 25
      Fungi: 304
      Plants: 511
    rate_ratio: 0.0318
    p_value: 4.45e-22
    q_value: 5.84e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P27340
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001901
    - protein: UniProtKB:Q6LXB7
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001901
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006886
  - go_id: GO:0000729
    label: DNA double-strand break processing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 76
      Archaea: 0
      Bacteria: 0
      Fungi: 26
      Plants: 3
    rate_ratio: 0.0319
    p_value: 1.91e-14
    q_value: 1.53e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QPA7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000743674|SGD:S000000017|UniProtKB:Q9H4L7
    - protein: UniProtKB:D8SL68
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000743674|SGD:S000000017|UniProtKB:Q9H4L7
    - protein: UniProtKB:Q9ZUL5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000743674|SGD:S000000017|UniProtKB:Q9H4L7
  - go_id: GO:0016682
    label: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 29
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0321
    p_value: 3.3e-15
    q_value: 2.81e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:C7B2F5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000352928
    - protein: UniProtKB:F4I4K5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17496893
      assigned_by: TAIR
    - protein: UniProtKB:Q39224
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:8883383
      assigned_by: TAIR
  - go_id: GO:0010647
    label: positive regulation of cell communication
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 176
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0321
    p_value: 1.97e-11
    q_value: 1.26e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SEU7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19218459
      assigned_by: UniProt
  - go_id: GO:0008053
    label: mitochondrial fusion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 351
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 2
    rate_ratio: 0.0322
    p_value: 4.41e-22
    q_value: 5.81e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C542
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:42018423
      assigned_by: UniProt
    - protein: UniProtKB:Q9ZUN9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:42018423
      assigned_by: UniProt
  - go_id: GO:1990426
    label: mitotic recombination-dependent replication fork processing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 12
      Archaea: 0
      Bacteria: 0
      Fungi: 17
      Plants: 2
    rate_ratio: 0.0325
    p_value: 1.09e-09
    q_value: 5.97e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8BGT9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011941
    - protein: UniProtKB:P94102
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011941
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990426
  - go_id: GO:0000354
    label: cis assembly of pre-catalytic spliceosome
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O75643
      taxon: NCBITaxon:9606
      evidence: IC
      reference: PMID:9539711
      assigned_by: HGNC-UCL
      with_from: GO:0005682
    - protein: UniProtKB:Q9BUQ8
      taxon: NCBITaxon:9606
      evidence: IC
      reference: PMID:9539711
      assigned_by: HGNC-UCL
      with_from: GO:0005682
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000354
  - go_id: GO:0032867
    label: L-arabinose reductase (NADPH) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15121
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:25229
    - protein: UniProtKB:P45376
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:25229
  - go_id: GO:0042131
    label: thiamine phosphate phosphatase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15309
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8CE08|ensembl:ENSMUSP00000059889
    - protein: UniProtKB:P15309
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: CAFA
      with_from: UniProtKB:Q8CE08
    - protein: UniProtKB:Q8CE08
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18940592
      assigned_by: UniProt
  - go_id: GO:1905534
    label: positive regulation of L-leucine import across plasma membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q01650
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q63016|ensembl:ENSRNOP00000025784
    - protein: UniProtKB:Q9Z127
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q63016|ensembl:ENSRNOP00000025784
    - protein: UniProtKB:Q9Z127
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:620639
  - go_id: GO:0070202
    label: regulation of establishment of protein localization to chromosome
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q14159
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002154254|UniProtKB:Q14159
    - protein: UniProtKB:Q14159
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:23509288
      assigned_by: UniProt
    - protein: UniProtKB:Q8BGX7
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002154254|UniProtKB:Q14159
    - protein: UniProtKB:Q8BGX7
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q14159|ensembl:ENSP00000297423
    - protein: UniProtKB:Q8BGX7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q14159
    - protein: UniProtKB:Q8BGX7
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q14159
  - go_id: GO:0001112
    label: DNA-templated transcription open complex formation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7Z7C8
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:14580349
      assigned_by: MGI
    - protein: UniProtKB:Q9EQH4
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: PMID:14580349
      assigned_by: MGI
      with_from: UniProtKB:Q7Z7C8
  - go_id: GO:0004037
    label: allantoicase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8N6M5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005164|InterPro:IPR015908
      gene_review: genes/human/ALLC/ALLC-ai-review.yaml
    - protein: UniProtKB:Q8N6M5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9JHX6|ensembl:ENSMUSP00000020965
      gene_review: genes/human/ALLC/ALLC-ai-review.yaml
    - protein: UniProtKB:Q9JHX6
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:11852104
      assigned_by: MGI
    - protein: UniProtKB:Q9JHX6
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005164|InterPro:IPR015908
  - go_id: GO:0046520
    label: sphingoid biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 4
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8BG54
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000008
      assigned_by: MGI
      with_from: UniProtKB:Q9NUV7
    - protein: UniProtKB:Q9NUV7
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:19648650
      assigned_by: MGI
  - go_id: GO:0004754
    label: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9UDR5
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q9VLX0
      gene_review: genes/human/AASS/AASS-ai-review.yaml
    - protein: UniProtKB:Q9VLX0
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:18695041
      assigned_by: FlyBase
  - go_id: GO:0031078
    label: histone H3K14 deacetylase activity, hydrolytic mechanism
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q99N13
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:21708950
      assigned_by: ARUK-UCL
    - protein: UniProtKB:Q9UKV0
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: PMID:21708950
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q99N13
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0031078
  - go_id: GO:1990545
    label: mitochondrial thiamine pyrophosphate transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4K7P9
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: PMID:20121944
      assigned_by: FlyBase
      with_from: FB:FBgn0037852
    - protein: UniProtKB:Q0KI86
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:20121944
      assigned_by: FlyBase
      with_from: SGD:S000003328
  - go_id: GO:0090052
    label: regulation of pericentric heterochromatin formation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KVA6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:25934801
      assigned_by: FlyBase
    - protein: UniProtKB:Q9W061
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:25934801
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0090052
  - go_id: GO:0071311
    label: cellular response to acetate
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VRL4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:23804096
      assigned_by: FlyBase
    - protein: UniProtKB:Q9W365
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:23804096
      assigned_by: FlyBase
  - go_id: GO:1990621
    label: ESCRT IV complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W0B3
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: SGD:S000004171
    - protein: UniProtKB:Q9W0B3
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:25486452
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q9Y162
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P52917
    - protein: UniProtKB:Q9Y162
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:25486452
      assigned_by: ComplexPortal
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990621
  - go_id: GO:0070199
    label: establishment of protein localization to chromosome
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0326
    p_value: 0.00188
    q_value: 0.00425
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EDA3
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:11402065
      assigned_by: UniProt
    - protein: UniProtKB:P34470
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:11402065
      assigned_by: UniProt
    - protein: UniProtKB:P34470
      taxon: NCBITaxon:6239
      evidence: TAS
      reference: PMID:11402065
      assigned_by: UniProt
  - go_id: GO:0005901
    label: caveola
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 521
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0326
    p_value: 2.43e-32
    q_value: 5.25e-31
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4V3D6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0035
    - protein: UniProtKB:Q501E6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0035
    - protein: UniProtKB:Q9LV90
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0035
  - go_id: GO:0042803
    label: protein homodimerization activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3712
      Archaea: 2
      Bacteria: 333
      Fungi: 37
      Plants: 269
    rate_ratio: 0.0326
    p_value: 1.06e-21
    q_value: 1.36e-20
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9HJ84
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000740
    - protein: UniProtKB:Q9HK01
      taxon: NCBITaxon:273075
      evidence: IDA
      reference: PMID:16458304
      assigned_by: UniProt
  - go_id: GO:0090292
    label: nuclear matrix anchoring at nuclear membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 173
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0327
    p_value: 3.16e-11
    q_value: 1.98e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KG14
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:36269771
      assigned_by: TAIR
    - protein: UniProtKB:F4KG14
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:36269771
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G67230|AGI_LocusCode:AT5G20200
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0090292
  - go_id: GO:0008718
    label: D-amino-acid dehydrogenase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 5
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0329
    p_value: 3.74e-05
    q_value: 0.000116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZIU2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P18894|ensembl:ENSMUSP00000107911
    - protein: UniProtKB:P14920
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P18894|ensembl:ENSMUSP00000107911
    - protein: UniProtKB:P18894
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:1686595
      assigned_by: UniProt
  - go_id: GO:0008663
    label: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 5
      Fungi: 1
      Plants: 4
    rate_ratio: 0.0329
    p_value: 3.74e-05
    q_value: 0.000116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AKT7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000421113|ZFIN:ZDB-GENE-040426-1406
    - protein: UniProtKB:Q3LIE5
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000421113|ZFIN:ZDB-GENE-040426-1406
    - protein: UniProtKB:Q99KS6
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000421113|ZFIN:ZDB-GENE-040426-1406
  - go_id: GO:0046052
    label: UTP catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 5
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0329
    p_value: 3.74e-05
    q_value: 0.000116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZPA6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NQZ7|ensembl:ENSP00000359520
    - protein: UniProtKB:Q3TCT4
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NQZ7|ensembl:ENSP00000359520
    - protein: UniProtKB:Q3TCT4
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NQZ7
    - protein: UniProtKB:Q3TCT4
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9NQZ7
    - protein: UniProtKB:Q9NQZ7
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:11278936
      assigned_by: UniProt
  - go_id: GO:0035485
    label: adenine/guanine mispair binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 5
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0329
    p_value: 3.74e-05
    q_value: 0.000116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AAE7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000040628|PomBase:SPAC26A3.02
    - protein: UniProtKB:Q99P21
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000040628|PomBase:SPAC26A3.02
    - protein: UniProtKB:Q9UIF7
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000040628|PomBase:SPAC26A3.02
  - go_id: GO:0006283
    label: transcription-coupled nucleotide-excision repair
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 88
      Archaea: 0
      Bacteria: 1
      Fungi: 27
      Plants: 19
    rate_ratio: 0.033
    p_value: 4.52e-08
    q_value: 2.08e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P30958
      taxon: NCBITaxon:83333
      evidence: EXP
      reference: PMID:1763073
      assigned_by: EcoCyc
    - protein: UniProtKB:P30958
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:22960746
      assigned_by: EcoCyc
    - protein: UniProtKB:P30958
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:8465200
      assigned_by: EcoCyc
    - protein: UniProtKB:P30958
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:1763073
      assigned_by: EcoCyc
  - go_id: GO:0008298
    label: intracellular mRNA localization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 61
      Archaea: 0
      Bacteria: 1
      Fungi: 27
      Plants: 4
    rate_ratio: 0.033
    p_value: 4.52e-08
    q_value: 2.08e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AEZ3
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:38243117
      assigned_by: EcoCyc
  - go_id: GO:0050830
    label: defense response to Gram-positive bacterium
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 551
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0331
    p_value: 9.75e-12
    q_value: 6.39e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P68577
      taxon: NCBITaxon:224308
      evidence: IDA
      reference: PMID:21196935
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0050830
  - go_id: GO:0023056
    label: positive regulation of signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 171
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0331
    p_value: 4.33e-11
    q_value: 2.68e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SD42
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:28541511
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G26070
  - go_id: GO:0070914
    label: UV-damage excision repair
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 67
      Archaea: 0
      Bacteria: 1
      Fungi: 25
      Plants: 3
    rate_ratio: 0.0332
    p_value: 7.9e-14
    q_value: 6.07e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RQ83
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000297520|WB:WBGene00008665
    - protein: UniProtKB:D8TDH1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000297520|WB:WBGene00008665
    - protein: UniProtKB:Q9MA98
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000297520|WB:WBGene00008665
  - go_id: GO:0051880
    label: G-quadruplex DNA binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 49
      Archaea: 0
      Bacteria: 1
      Fungi: 25
      Plants: 3
    rate_ratio: 0.0332
    p_value: 7.9e-14
    q_value: 6.07e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QZS8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000429848|SGD:S000005194
    - protein: UniProtKB:D8TC60
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000429848|SGD:S000005194
    - protein: UniProtKB:Q9SL02
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000429848|SGD:S000005194
  - go_id: GO:0006388
    label: tRNA splicing, via endonucleolytic cleavage and ligation
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 130
      Archaea: 11
      Bacteria: 2
      Fungi: 22
      Plants: 32
    rate_ratio: 0.0334
    p_value: 1.46e-07
    q_value: 6.36e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39380
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000034439
    - protein: UniProtKB:Q02V26
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000034439
  - go_id: GO:0051239
    label: regulation of multicellular organismal process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 505
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0336
    p_value: 3.0e-31
    q_value: 6.15e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RNZ2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028859
    - protein: UniProtKB:D8SXB6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028859
    - protein: UniProtKB:Q9M8Z5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028859
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0051239
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0051239
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0051239
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0051239
  - go_id: GO:0004303
    label: estradiol 17-beta-dehydrogenase [NAD(P)+] activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 166
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0341
    p_value: 9.5e-11
    q_value: 5.72e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0DKC5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24616
  - go_id: GO:0052837
    label: thiazole biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 11
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0343
    p_value: 4.49e-05
    q_value: 0.000138
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RPN5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000065314|PomBase:SPBC26H8.01|SGD:S000003376|UniProtKB:Q58018
    - protein: UniProtKB:D8RPN5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375967
    - protein: UniProtKB:D8TFQ8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000065314|PomBase:SPBC26H8.01|SGD:S000003376|UniProtKB:Q58018
    - protein: UniProtKB:D8TFQ8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375967
    - protein: UniProtKB:Q38814
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000065314|PomBase:SPBC26H8.01|SGD:S000003376|UniProtKB:Q58018
    - protein: UniProtKB:Q38814
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375967
  - go_id: GO:0032206
    label: positive regulation of telomere maintenance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 165
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.0343
    p_value: 1.11e-10
    q_value: 6.65e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q56Y52
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16107718
      assigned_by: UniProt
  - go_id: GO:0002020
    label: protease binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 597
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 7
    rate_ratio: 0.0343
    p_value: 2.48e-11
    q_value: 1.57e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P01094
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:10655612
      assigned_by: CAFA
      with_from: UniProtKB:P07267
    - protein: UniProtKB:P01094
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:15065849
      assigned_by: CAFA
      with_from: UniProtKB:P07267
  - go_id: GO:0008240
    label: tripeptidyl-peptidase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 70
      Archaea: 6
      Bacteria: 0
      Fungi: 1
      Plants: 4
    rate_ratio: 0.0344
    p_value: 0.000302
    q_value: 0.0008
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9UT05
      taxon: NCBITaxon:284812
      evidence: EXP
      reference: PMID:9740805
      assigned_by: UniProt
    - protein: UniProtKB:Q9UT05
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G20850|FB:FBgn0020370|PANTHER:PTN000083315|PomBase:SPAP8A3.12c|RGD:621584|UniProtKB:P29144
    - protein: UniProtKB:Q9UT05
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR034051
    - protein: UniProtKB:Q9UT05
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.4.14.10
    - protein: UniProtKB:Q9UT05
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00092315
    - protein: UniProtKB:Q9UT05
      taxon: NCBITaxon:284812
      evidence: IMP
      reference: PMID:19467630
      assigned_by: PomBase
  - go_id: GO:0034775
    label: glutathione transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 29
      Archaea: 0
      Bacteria: 9
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0345
    p_value: 3.69e-05
    q_value: 0.000115
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q680I5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20959624
      assigned_by: TAIR
  - go_id: GO:0042355
    label: L-fucose catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 9
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0345
    p_value: 3.69e-05
    q_value: 0.000115
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LJK1
      taxon: NCBITaxon:3702
      evidence: NAS
      reference: PMID:11698403
      assigned_by: UniProt
  - go_id: GO:0008677
    label: 2-dehydropantoate 2-reductase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 9
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0345
    p_value: 3.69e-05
    q_value: 0.000115
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4KIN4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.169
    - protein: UniProtKB:F4KIN4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:16233
    - protein: UniProtKB:F4KIN4
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:14675432
      assigned_by: TAIR
  - go_id: GO:0047809
    label: D-lactate dehydrogenase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 9
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0345
    p_value: 3.69e-05
    q_value: 0.000115
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AX4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00093753
  - go_id: GO:0004114
    label: 3',5'-cyclic-nucleotide phosphodiesterase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 328
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0345
    p_value: 1.63e-20
    q_value: 1.97e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T0K1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002073|InterPro:IPR036971
    - protein: UniProtKB:D8TER4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002073|InterPro:IPR036971
  - go_id: GO:1901612
    label: cardiolipin binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 81
      Archaea: 0
      Bacteria: 4
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ASV5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26898467
      assigned_by: TAIR
  - go_id: GO:0035024
    label: negative regulation of Rho protein signal transduction
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 105
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JQZ3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19108776
      assigned_by: TAIR
  - go_id: GO:0180020
    label: membrane bending activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 25
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 2
    rate_ratio: 0.0345
    p_value: 4.51e-09
    q_value: 2.32e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S6Z2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001398562|PomBase:SPBC1539.04
    - protein: UniProtKB:D8T7G1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001398562|PomBase:SPBC1539.04
  - go_id: GO:0140008
    label: histone H4 reader activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 24
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IAE9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27273316
      assigned_by: TAIR
  - go_id: GO:0046827
    label: positive regulation of protein export from nucleus
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 88
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q39011
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17873094
      assigned_by: TAIR
      gene_review: genes/ARATH/BIN2/BIN2-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0046827
  - go_id: GO:0010828
    label: positive regulation of D-glucose transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 45
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XI87
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21838775
      assigned_by: UniProt
  - go_id: GO:0000292
    label: RNA fragment catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 9
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JAA5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26464441
      assigned_by: TAIR
  - go_id: GO:0006793
    label: phosphorus metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 6
      Fungi: 8
      Plants: 1
    rate_ratio: 0.0345
    p_value: 7.01e-05
    q_value: 0.000209
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q93Z81
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:16055687
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G38170
  - go_id: GO:0001725
    label: stress fiber
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 591
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0346
    p_value: 3.27e-11
    q_value: 2.04e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PU66
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0501
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0001725
  - go_id: GO:0009190
    label: cyclic nucleotide biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 324
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0349
    p_value: 3.06e-20
    q_value: 3.63e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T0K1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001054
    - protein: UniProtKB:D8TER4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001054
  - go_id: GO:0031941
    label: filamentous actin
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 160
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0353
    p_value: 2.44e-10
    q_value: 1.42e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94KK5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27866894
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031941
  - go_id: GO:0035445
    label: borate transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 15
    rate_ratio: 0.0354
    p_value: 4.65e-10
    q_value: 2.64e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2AJN7
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0080139
    - protein: UniProtKB:A2AJN8
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0080139
    - protein: UniProtKB:Q8NBS3
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0080139
  - go_id: GO:0016444
    label: somatic cell DNA recombination
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 10
    rate_ratio: 0.0354
    p_value: 5.77e-07
    q_value: 2.32e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6A028
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:9642267
      assigned_by: MGI
    - protein: UniProtKB:Q9VGN7
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18056975
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0016444
  - go_id: GO:0016041
    label: glutamate synthase (ferredoxin) activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 5
    rate_ratio: 0.0354
    p_value: 0.000804
    q_value: 0.00197
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9PCU8
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.4.7.1|EC:1.4.7.1
  - go_id: GO:0034196
    label: acylglycerol transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 5
    rate_ratio: 0.0354
    p_value: 0.000804
    q_value: 0.00197
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KTG2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22844248
      assigned_by: FlyBase
  - go_id: GO:0140496
    label: gamma-tubulin complex binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 5
    rate_ratio: 0.0354
    p_value: 0.000804
    q_value: 0.00197
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V877
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:30087124
      assigned_by: FlyBase
  - go_id: GO:1903844
    label: regulation of cellular response to transforming growth factor beta stimulus
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 5
    rate_ratio: 0.0354
    p_value: 0.000804
    q_value: 0.00197
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W1N4
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033909
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:1903844
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:1903844
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:1903844
  - go_id: GO:0009637
    label: response to blue light
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 91
    rate_ratio: 0.0354
    p_value: 9.36e-10
    q_value: 5.17e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P75990
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:19240136
      assigned_by: EcoCyc
  - go_id: GO:0051247
    label: positive regulation of protein metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 319
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0355
    p_value: 6.69e-20
    q_value: 7.75e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3E7K4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26554020
      assigned_by: TAIR
    - protein: UniProtKB:Q9FMV5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26554020
      assigned_by: TAIR
  - go_id: GO:1990756
    label: ubiquitin-like ligase-substrate adaptor activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 892
      Archaea: 0
      Bacteria: 2
      Fungi: 50
      Plants: 63
    rate_ratio: 0.0356
    p_value: 3.42e-14
    q_value: 2.7e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O31912
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN007723485|UniProtKB:Q86XK2
    - protein: UniProtKB:P94409
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN007723485|UniProtKB:Q86XK2
  - go_id: GO:0042134
    label: rRNA primary transcript binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 39
      Archaea: 2
      Bacteria: 1
      Fungi: 25
      Plants: 11
    rate_ratio: 0.0356
    p_value: 1.9e-07
    q_value: 8.13e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0ADG4
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:31020314
      assigned_by: EcoCyc
    - protein: UniProtKB:P0ADG4
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:31127279
      assigned_by: EcoCyc
  - go_id: GO:0030971
    label: receptor tyrosine kinase binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 314
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.036
    p_value: 1.46e-19
    q_value: 1.66e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P94040
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:37979582
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G66150
    - protein: UniProtKB:P94072
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:37979582
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G66150
  - go_id: GO:0032008
    label: positive regulation of TOR signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 313
      Archaea: 1
      Bacteria: 0
      Fungi: 13
      Plants: 2
    rate_ratio: 0.0361
    p_value: 1.71e-19
    q_value: 1.93e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LDQ4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25399018
      assigned_by: UniProt
    - protein: UniProtKB:Q9SLA6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008690749|UniProtKB:A0A3P5Y7D0
  - go_id: GO:2000036
    label: regulation of stem cell population maintenance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 156
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0363
    p_value: 4.56e-10
    q_value: 2.59e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LKZ3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16377572
      assigned_by: TAIR
    - protein: UniProtKB:Q9LKZ3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20525851
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:2000036
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:2000036
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:2000036
  - go_id: GO:0120243
    label: 2-iminopropanoate deaminase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0366
    p_value: 0.0026
    q_value: 0.00573
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P52758
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:22094463
      assigned_by: UniProt
    - protein: UniProtKB:P52758
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:40671
    - protein: UniProtKB:P52760
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:40671
    - protein: UniProtKB:P52760
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P52758
    - protein: UniProtKB:P52760
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P52758
  - go_id: GO:0106009
    label: (4S)-4-hydroxy-2-oxoglutarate aldolase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.0026
    q_value: 0.00573
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q86XE5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:35639
      gene_review: genes/human/HOGA1/HOGA1-ai-review.yaml
    - protein: UniProtKB:Q9DCU9
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:35639
  - go_id: GO:0061163
    label: endoplasmic reticulum polarization
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZT01
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8K2Q9|ensembl:ENSMUSP00000041378
    - protein: UniProtKB:A0MZ66
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8K2Q9|ensembl:ENSMUSP00000041378
    - protein: UniProtKB:A0MZ66
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8K2Q9
    - protein: UniProtKB:Q8K2Q9
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:23864681
      assigned_by: UniProt
  - go_id: GO:0032038
    label: myosin II heavy chain binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08590
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:16675844
      assigned_by: BHF-UCL
    - protein: UniProtKB:P12829
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:16675844
      assigned_by: BHF-UCL
    - protein: UniProtKB:Q9VJ14
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:18216171
      assigned_by: FlyBase
      with_from: FB:FBgn0287873
  - go_id: GO:0035543
    label: positive regulation of SNARE complex assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XZX1
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P37840|ensembl:ENSP00000378442
    - protein: UniProtKB:O55042
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P37840
    - protein: UniProtKB:P37840
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20798282
      assigned_by: CACAO
      gene_review: genes/human/SNCA/SNCA-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0035543
  - go_id: GO:0048313
    label: Golgi inheritance
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P31938
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q01986|ensembl:ENSRNOP00000084527
    - protein: UniProtKB:P31938
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:70495
    - protein: UniProtKB:P53350
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-162658
      assigned_by: Reactome
      gene_review: genes/human/PLK1/PLK1-ai-review.yaml
    - protein: UniProtKB:Q02750
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q01986|ensembl:ENSRNOP00000084527
      gene_review: genes/human/MAP2K1/MAP2K1-ai-review.yaml
  - go_id: GO:0018063
    label: cytochrome c-heme linkage
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G3UXK7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P53701
    - protein: UniProtKB:P53701
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:23150584
      assigned_by: UniProt
    - protein: UniProtKB:P53702
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P53701
  - go_id: GO:0032377
    label: regulation of intracellular lipid transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 8
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F1N859
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001260854|UniProtKB:Q5BJF2
    - protein: UniProtKB:F1N859
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q5BJF2|ensembl:ENSP00000226230
    - protein: UniProtKB:Q5BJF2
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001260854|UniProtKB:Q5BJF2
    - protein: UniProtKB:Q5BJF2
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:27378690
      assigned_by: UniProt
    - protein: UniProtKB:Q8VD00
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001260854|UniProtKB:Q5BJF2
    - protein: UniProtKB:Q8VD00
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q5BJF2|ensembl:ENSP00000226230
    - protein: UniProtKB:Q8VD00
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q5BJF2
    - protein: UniProtKB:Q8VD00
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q5BJF2
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0032377
  - go_id: GO:0071618
    label: lysophosphatidylethanolamine acyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZLA3
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q91YX5|ensembl:ENSMUSP00000106479
    - protein: UniProtKB:Q91YX5
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:35131264
      assigned_by: UniProt
    - protein: UniProtKB:Q92604
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q91YX5|ensembl:ENSMUSP00000106479
      gene_review: genes/human/LPGAT1/LPGAT1-ai-review.yaml
    - protein: UniProtKB:Q92604
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q91YX5
      gene_review: genes/human/LPGAT1/LPGAT1-ai-review.yaml
  - go_id: GO:0140013
    label: meiotic nuclear division
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Y4A4
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P35290|ensembl:ENSMUSP00000046188
    - protein: UniProtKB:P35290
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:31496367
      assigned_by: UniProt
    - protein: UniProtKB:Q969Q5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P35290|ensembl:ENSMUSP00000046188
      gene_review: genes/human/RAB24/RAB24-ai-review.yaml
    - protein: UniProtKB:Q969Q5
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P35290
      gene_review: genes/human/RAB24/RAB24-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0140013
  - go_id: GO:0097080
    label: plasma membrane selenite transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XRS0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q91W10|ensembl:ENSMUSP00000029810
    - protein: UniProtKB:A0A8V0XRS0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9C0K1|ensembl:ENSP00000349174
    - protein: UniProtKB:Q91W10
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:27166256
      assigned_by: UniProt
    - protein: UniProtKB:Q91W10
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9C0K1|ensembl:ENSP00000349174
    - protein: UniProtKB:Q91W10
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9C0K1
    - protein: UniProtKB:Q9C0K1
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:27166256
      assigned_by: UniProt
    - protein: UniProtKB:Q9C0K1
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q91W10|ensembl:ENSMUSP00000029810
  - go_id: GO:0097505
    label: Rad6-Rad18 complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Z470
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001020335|SGD:S000000662
    - protein: UniProtKB:Q9NS91
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001020335|SGD:S000000662
      gene_review: genes/human/RAD18/RAD18-ai-review.yaml
    - protein: UniProtKB:Q9QXK2
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001020335|SGD:S000000662
  - go_id: GO:1905589
    label: positive regulation of L-arginine import across plasma membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A5F8MPW1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2069
    - protein: UniProtKB:F6UJJ0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2069
    - protein: UniProtKB:P11859
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2069
  - go_id: GO:2001246
    label: negative regulation of phosphatidylcholine biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D6RE48
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:20018880
      assigned_by: MGI
    - protein: UniProtKB:D6RFA8
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:20018880
      assigned_by: MGI
    - protein: UniProtKB:Q3TFD2
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:20018880
      assigned_by: MGI
  - go_id: GO:2001208
    label: negative regulation of transcription elongation by RNA polymerase I
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A8DYA3
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:22426536
      assigned_by: ComplexPortal
    - protein: UniProtKB:O46036
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:22426536
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q24368
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:22426536
      assigned_by: ComplexPortal
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:2001208
  - go_id: GO:0070485
    label: dehydro-D-arabinono-1,4-lactone biosynthetic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VGF1
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q04212
    - protein: UniProtKB:Q9VGF2
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q04212
    - protein: UniProtKB:Q9VGF3
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q04212
      gene_review: genes/DROME/CG18547/CG18547-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0070485
  - go_id: GO:1990893
    label: mitotic chromosome centromere condensation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 0
    rate_ratio: 0.0366
    p_value: 0.000294
    q_value: 0.000782
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EEH9
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:28122936
      assigned_by: UniProt
    - protein: UniProtKB:Q9BKT9
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:28122936
      assigned_by: UniProt
    - protein: UniProtKB:Q9N4A7
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:28122936
      assigned_by: UniProt
      gene_review: genes/worm/npp-20/npp-20-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990893
  - go_id: GO:0005700
    label: polytene chromosome
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 154
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0367
    p_value: 6.24e-10
    q_value: 3.5e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RAW7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0011474|PANTHER:PTN002920257
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005700
  - go_id: GO:0030337
    label: DNA polymerase processivity factor activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 19
      Archaea: 5
      Bacteria: 1
      Fungi: 7
      Plants: 4
    rate_ratio: 0.0368
    p_value: 0.000946
    q_value: 0.00227
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AA25
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:30265524
      assigned_by: FlyBase
  - go_id: GO:0015612
    label: ABC-type L-arabinose transporter activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0368
    p_value: 0.000946
    q_value: 0.00227
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AAF3
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:7.5.2.12
    - protein: UniProtKB:P0AAF3
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:30007
  - go_id: GO:0015614
    label: ABC-type D-xylose transporter activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0368
    p_value: 0.000946
    q_value: 0.00227
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P37388
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR013455
    - protein: UniProtKB:P37388
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:7.5.2.10
    - protein: UniProtKB:P37388
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:29899
  - go_id: GO:0047475
    label: phenylacetate-CoA ligase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 5
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0368
    p_value: 0.000946
    q_value: 0.00227
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000644795|UniProtKB:P76085
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011880
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.2.1.30
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:20956
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00091051
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IEP
      reference: PMID:9748275
      assigned_by: EcoCyc
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
    - protein: UniProtKB:P76085
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:9748275
      assigned_by: EcoliWiki
      gene_review: genes/ECOLI/paaK/paaK-ai-review.yaml
  - go_id: GO:0051598
    label: meiotic recombination checkpoint signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 0
      Fungi: 15
      Plants: 2
    rate_ratio: 0.0368
    p_value: 1.86e-08
    q_value: 8.85e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HRV8
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1915231|PANTHER:PTN008491432|SGD:S000001334
    - protein: UniProtKB:Q8H1F9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0051453|PANTHER:PTN000554401|SGD:S000000390
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051598
  - go_id: GO:0006617
    label: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 1
      Bacteria: 0
      Fungi: 15
      Plants: 2
    rate_ratio: 0.0368
    p_value: 1.86e-08
    q_value: 8.85e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T2Q1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000193644|PANTHER:PTN000425879|SGD:S000004573
    - protein: UniProtKB:Q943Z6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000193644|PANTHER:PTN000425879|SGD:S000004573
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006617
  - go_id: GO:0010411
    label: xyloglucan metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 87
    rate_ratio: 0.037
    p_value: 2.64e-09
    q_value: 1.39e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z8T9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN008119022
  - go_id: GO:0006278
    label: RNA-templated DNA biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 163
      Archaea: 0
      Bacteria: 3
      Fungi: 72
      Plants: 13
    rate_ratio: 0.0371
    p_value: 5.9e-20
    q_value: 6.85e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKI8
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0003964
    - protein: UniProtKB:Q188V0
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0003964
    - protein: UniProtKB:Q8ZKY2
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000123
  - go_id: GO:0097009
    label: energy homeostasis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 304
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0372
    p_value: 7.0e-19
    q_value: 7.6e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7X9B9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:36752317
      assigned_by: TAIR
    - protein: UniProtKB:Q9FIJ7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18162585
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0097009
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0097009
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0097009
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0097009
  - go_id: GO:0004382
    label: GDP phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 152
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.0372
    p_value: 8.53e-10
    q_value: 4.73e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SQG2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22849572
      assigned_by: TAIR
  - go_id: GO:0000398
    label: mRNA splicing, via spliceosome
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1964
      Archaea: 2
      Bacteria: 0
      Fungi: 259
      Plants: 403
    rate_ratio: 0.0374
    p_value: 1.53e-18
    q_value: 1.61e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P57670
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR016487
    - protein: UniProtKB:Q4JAL0
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR016487
  - go_id: GO:0045335
    label: phagocytic vesicle
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 451
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0376
    p_value: 1.41e-27
    q_value: 2.42e-26
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VY27
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0206
    - protein: UniProtKB:Q9FGH9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0206
    - protein: UniProtKB:Q9LMJ4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0206
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0045335
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045335
  - go_id: GO:0000403
    label: Y-form DNA binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 36
      Archaea: 3
      Bacteria: 0
      Fungi: 22
      Plants: 3
    rate_ratio: 0.0377
    p_value: 5.49e-12
    q_value: 3.69e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1I9LR82
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000325249|PomBase:SPBC30D10.04
    - protein: UniProtKB:D8SVF6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000325249|PomBase:SPBC30D10.04
    - protein: UniProtKB:D8T0Q4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000325249|PomBase:SPBC30D10.04
  - go_id: GO:0033176
    label: proton-transporting V-type ATPase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 77
      Archaea: 0
      Bacteria: 0
      Fungi: 22
      Plants: 3
    rate_ratio: 0.0377
    p_value: 5.49e-12
    q_value: 3.69e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SKE5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0022097|MGI:MGI:1921084|PANTHER:PTN002268884|SGD:S000000777|UniProtKB:O59941|UniProtKB:P39942|UniProtKB:Q9Y5K8
    - protein: UniProtKB:D8T0F9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0022097|MGI:MGI:1921084|PANTHER:PTN002268884|SGD:S000000777|UniProtKB:O59941|UniProtKB:P39942|UniProtKB:Q9Y5K8
    - protein: UniProtKB:Q9XGM1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0022097|MGI:MGI:1921084|PANTHER:PTN002268884|SGD:S000000777|UniProtKB:O59941|UniProtKB:P39942|UniProtKB:Q9Y5K8
  - go_id: GO:0031559
    label: oxidosqualene cyclase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 14
    rate_ratio: 0.0379
    p_value: 2.58e-09
    q_value: 1.36e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0G2JQD0
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026617
    - protein: UniProtKB:A0A8V0YEB4
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026617
    - protein: UniProtKB:A0ACI8S916
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026617
  - go_id: GO:0019203
    label: carbohydrate phosphatase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 14
    rate_ratio: 0.0379
    p_value: 2.58e-09
    q_value: 1.36e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XX26
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045204
    - protein: UniProtKB:A0A8V0XX26
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028086
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:16901901
      assigned_by: Reactome
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:25538239
      assigned_by: UniProt
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045204
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9WUA5|ensembl:ENSMUSP00000066050
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028086
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:O95278
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-3781011
      assigned_by: Reactome
      gene_review: genes/human/EPM2A/EPM2A-ai-review.yaml
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:18040046
      assigned_by: MGI
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045204
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:O95278|ensembl:ENSP00000356489
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028086
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18040046
      assigned_by: MGI
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:B3EWF7
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:O95278
    - protein: UniProtKB:Q9WUA5
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:O95278
  - go_id: GO:0102521
    label: tRNA-4-demethylwyosine synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 18
      Archaea: 3
      Bacteria: 0
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0381
    p_value: 0.0029
    q_value: 0.00634
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RBB7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.1.3.44|EC:4.1.3.44
    - protein: UniProtKB:Q8RXN5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.1.3.44
    - protein: UniProtKB:Q8RXN5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:36347
  - go_id: GO:0170057
    label: RNA ligase (GTP) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 18
      Archaea: 3
      Bacteria: 6
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0381
    p_value: 0.0029
    q_value: 0.00634
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SNU5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000122119|UniProtKB:Q8ZY09|WB:WBGene00008877
    - protein: UniProtKB:D8SNU5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001233|InterPro:IPR036025
    - protein: UniProtKB:D8SNU5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.5.1.8|EC:6.5.1.8
    - protein: UniProtKB:D8SS91
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000122119|UniProtKB:Q8ZY09|WB:WBGene00008877
    - protein: UniProtKB:D8SS91
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001233|InterPro:IPR036025
    - protein: UniProtKB:D8SS91
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.5.1.8|EC:6.5.1.8
  - go_id: GO:0004321
    label: fatty-acyl-CoA synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 18
      Archaea: 3
      Bacteria: 2
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0381
    p_value: 0.0029
    q_value: 0.00634
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84P23
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15677481
      assigned_by: TAIR
    - protein: UniProtKB:Q9M0X9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15677481
      assigned_by: TAIR
  - go_id: GO:0015927
    label: trehalase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0381
    p_value: 0.0029
    q_value: 0.00634
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q67XC9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:24800789
      assigned_by: TAIR
    - protein: UniProtKB:Q9SU50
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026767
  - go_id: GO:0002218
    label: activation of innate immune response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 297
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0381
    p_value: 2.09e-18
    q_value: 2.19e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HT77
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:35597242
      assigned_by: UniProt
    - protein: UniProtKB:F4J2I0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24586161
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0002218
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0002218
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0002218
  - go_id: GO:0003964
    label: RNA-directed DNA polymerase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 153
      Archaea: 0
      Bacteria: 3
      Fungi: 70
      Plants: 14
    rate_ratio: 0.0381
    p_value: 2.45e-19
    q_value: 2.74e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKI8
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.7.49|EC:2.7.7.49
    - protein: UniProtKB:A0A0H2ZKI8
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000414873
    - protein: UniProtKB:Q188V0
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.7.49|EC:2.7.7.49
    - protein: UniProtKB:Q188V0
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000414873
    - protein: UniProtKB:Q8ZKY2
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000123
    - protein: UniProtKB:Q8ZKY2
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.7.49|EC:2.7.7.49
    - protein: UniProtKB:Q8ZKY2
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000414873
  - go_id: GO:0046513
    label: ceramide biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 367
      Archaea: 0
      Bacteria: 1
      Fungi: 23
      Plants: 37
    rate_ratio: 0.0387
    p_value: 7.92e-07
    q_value: 3.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZIT9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000306119
  - go_id: GO:0043047
    label: single-stranded telomeric DNA binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 80
      Archaea: 0
      Bacteria: 1
      Fungi: 23
      Plants: 34
    rate_ratio: 0.0387
    p_value: 7.92e-07
    q_value: 3.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZAI7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN007664302
  - go_id: GO:0031122
    label: cytoplasmic microtubule organization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 289
      Archaea: 0
      Bacteria: 1
      Fungi: 23
      Plants: 21
    rate_ratio: 0.0387
    p_value: 7.92e-07
    q_value: 3.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKN9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000436624
  - go_id: GO:0140693
    label: molecular condensate scaffold activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 326
      Archaea: 0
      Bacteria: 1
      Fungi: 23
      Plants: 10
    rate_ratio: 0.0387
    p_value: 7.92e-07
    q_value: 3.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A705
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:39975289
      assigned_by: DisProt
  - go_id: GO:0043021
    label: ribonucleoprotein complex binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 296
      Archaea: 0
      Bacteria: 1
      Fungi: 23
      Plants: 19
    rate_ratio: 0.0387
    p_value: 7.92e-07
    q_value: 3.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10408
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:28928132
      assigned_by: EcoCyc
      gene_review: genes/ECOLI/SecA/SecA-ai-review.yaml
  - go_id: GO:0030301
    label: cholesterol transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 146
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0387
    p_value: 2.18e-09
    q_value: 1.16e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I9G5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00034167
  - go_id: GO:0045134
    label: UDP phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 146
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.0387
    p_value: 2.18e-09
    q_value: 1.16e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SQG2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22849572
      assigned_by: TAIR
  - go_id: GO:0071453
    label: cellular response to oxygen levels
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 8
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0388
    p_value: 0.000141
    q_value: 0.000399
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C8N5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30882866
      assigned_by: TAIR
  - go_id: GO:0015129
    label: lactate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 44
      Archaea: 0
      Bacteria: 8
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0388
    p_value: 0.000141
    q_value: 0.000399
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8W037
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17584741
      assigned_by: TAIR
  - go_id: GO:0035873
    label: lactate transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 41
      Archaea: 0
      Bacteria: 8
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0388
    p_value: 0.000141
    q_value: 0.000399
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8W037
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015129
  - go_id: GO:0052816
    label: long-chain fatty acyl-CoA hydrolase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 101
      Archaea: 2
      Bacteria: 16
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0388
    p_value: 1.81e-08
    q_value: 8.67e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HU51
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:14660652
      assigned_by: UniProt
    - protein: UniProtKB:Q5FYU1
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:F4HU51
  - go_id: GO:0004040
    label: amidase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 16
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0388
    p_value: 1.81e-08
    q_value: 8.67e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8B760
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.1.4
    - protein: UniProtKB:A0A1P8B760
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12020
    - protein: UniProtKB:A0A1P8B760
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9FR37
    - protein: UniProtKB:Q9FR37
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:12620340
      assigned_by: UniProt
    - protein: UniProtKB:Q9FR37
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:27135507
      assigned_by: UniProt
    - protein: UniProtKB:Q9FR37
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17555521
      assigned_by: TAIR
    - protein: UniProtKB:Q9FR37
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.1.4
    - protein: UniProtKB:Q9FR37
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:64820|RHEA:64824|RHEA:12020
  - go_id: GO:0043101
    label: purine-containing compound salvage
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 8
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0388
    p_value: 0.000141
    q_value: 0.000399
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T0J1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084372
  - go_id: GO:0008959
    label: phosphate acetyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 8
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0388
    p_value: 0.000141
    q_value: 0.000399
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RE38
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.1.8|EC:2.3.1.8
  - go_id: GO:0019154
    label: glycolate dehydrogenase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 8
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0388
    p_value: 0.000141
    q_value: 0.000399
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AX4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:14966218
      assigned_by: TAIR
  - go_id: GO:0019213
    label: deacetylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 108
      Archaea: 0
      Bacteria: 24
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0388
    p_value: 2.62e-12
    q_value: 1.82e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RLU6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000189877|PANTHER:PTN000833391|SGD:S000004298|SGD:S000004299|UniProtKB:O34928|UniProtKB:Q8DP63
    - protein: UniProtKB:Q941D6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29247559
      assigned_by: UniProt
    - protein: UniProtKB:Q94AQ6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:24424322
      assigned_by: TAIR
  - go_id: GO:0017053
    label: transcription repressor complex
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 469
      Archaea: 0
      Bacteria: 1
      Fungi: 15
      Plants: 13
    rate_ratio: 0.0389
    p_value: 6.67e-10
    q_value: 3.72e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P06709
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:10497026
      assigned_by: CAFA
    - protein: UniProtKB:P06709
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:11124029
      assigned_by: CAFA
  - go_id: GO:0050714
    label: positive regulation of protein secretion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 288
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0393
    p_value: 8.52e-18
    q_value: 8.61e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4K183
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:39405432
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G09330,AGI_LocusCode:AT3G05940,AGI_LocusCode:AT5G26740
    - protein: UniProtKB:Q9SFF8
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:39405432
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G09330,AGI_LocusCode:AT3G05940,AGI_LocusCode:AT5G26740
  - go_id: GO:0043457
    label: regulation of cellular respiration
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 33
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q41188
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17376161
      assigned_by: UniProt
  - go_id: GO:1905323
    label: telomerase holoenzyme complex assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 41
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FMR9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30834599
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1905323
  - go_id: GO:0090148
    label: membrane fission
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 116
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LVF4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22530652
      assigned_by: UniProt
  - go_id: GO:0098562
    label: cytoplasmic side of membrane
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 28
      Archaea: 0
      Bacteria: 2
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6F6B5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15356321
      assigned_by: UniProt
  - go_id: GO:1990814
    label: DNA/DNA annealing activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 14
      Archaea: 0
      Bacteria: 4
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FT72
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19755539
      assigned_by: GO_Central
  - go_id: GO:0000707
    label: meiotic DNA recombinase assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GXF0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000534385|SGD:S000002483
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000707
  - go_id: GO:0034089
    label: establishment of meiotic sister chromatid cohesion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A7UL74
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23750584
      assigned_by: TAIR
  - go_id: GO:0015183
    label: L-aspartate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 46
      Archaea: 0
      Bacteria: 2
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SS86
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25005136
      assigned_by: TAIR
  - go_id: GO:0070778
    label: L-aspartate transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 35
      Archaea: 0
      Bacteria: 7
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SS86
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25005136
      assigned_by: TAIR
  - go_id: GO:0005955
    label: calcineurin complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 42
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O81223
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:9632394
      assigned_by: TAIR
      gene_review: genes/ARATH/CBL4/CBL4-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005955
  - go_id: GO:0015825
    label: L-serine transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 5
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q42400
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015194
  - go_id: GO:0000262
    label: mitochondrial chromosome
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 2
    rate_ratio: 0.0395
    p_value: 7.59e-08
    q_value: 3.42e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C504
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28420746
      assigned_by: TAIR
    - protein: UniProtKB:Q9M219
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34482561
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000262
  - go_id: GO:0090306
    label: meiotic spindle assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 1
    rate_ratio: 0.0395
    p_value: 0.000289
    q_value: 0.000773
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A9QM73
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18544632
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0090306
  - go_id: GO:0046354
    label: mannan biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 2
    rate_ratio: 0.0395
    p_value: 7.59e-08
    q_value: 3.42e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0WPA5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22966747
      assigned_by: UniProt
    - protein: UniProtKB:Q9LU40
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22966747
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0046354
  - go_id: GO:0071162
    label: CMG complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 75
      Archaea: 0
      Bacteria: 0
      Fungi: 21
      Plants: 3
    rate_ratio: 0.0395
    p_value: 2.24e-11
    q_value: 1.42e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8AW53
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0035194|PANTHER:PTN000308454|SGD:S000002420|UniProtKB:Q14691|UniProtKB:Q38F51|UniProtKB:Q7ZT47
    - protein: UniProtKB:D8R606
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0035194|PANTHER:PTN000308454|SGD:S000002420|UniProtKB:Q14691|UniProtKB:Q38F51|UniProtKB:Q7ZT47
    - protein: UniProtKB:D8SG75
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0035194|PANTHER:PTN000308454|SGD:S000002420|UniProtKB:Q14691|UniProtKB:Q38F51|UniProtKB:Q7ZT47
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071162
  - go_id: GO:0023051
    label: regulation of signaling
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 515
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 17
    rate_ratio: 0.0397
    p_value: 1.07e-09
    q_value: 5.89e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O13747
      taxon: NCBITaxon:284812
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: PomBase
      with_from: UniProtKB:Q7Z569
  - go_id: GO:0048608
    label: reproductive structure development
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 65
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 91
    rate_ratio: 0.0398
    p_value: 9.46e-09
    q_value: 4.66e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PNG6
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028277
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0048608
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0048608
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0048608
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0048608
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0048608
  - go_id: GO:0030198
    label: extracellular matrix organization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 910
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 9
    rate_ratio: 0.04
    p_value: 1.8e-18
    q_value: 1.89e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z759
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN008302825
    - protein: UniProtKB:Q17ZZ0
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001813385
  - go_id: GO:0016409
    label: palmitoyltransferase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 340
      Archaea: 0
      Bacteria: 1
      Fungi: 22
      Plants: 58
    rate_ratio: 0.0405
    p_value: 1.61e-06
    q_value: 6.09e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8ZR06
      taxon: NCBITaxon:99287
      evidence: IDA
      reference: PMID:11013210
      assigned_by: UniProt
    - protein: UniProtKB:Q8ZR06
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00043618
  - go_id: GO:0071280
    label: cellular response to copper ion
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 77
      Archaea: 0
      Bacteria: 1
      Fungi: 22
      Plants: 6
    rate_ratio: 0.0405
    p_value: 1.61e-06
    q_value: 6.09e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P77485
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:11004187
      assigned_by: EcoCyc
    - protein: UniProtKB:P77485
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:22348296
      assigned_by: EcoCyc
    - protein: UniProtKB:P77485
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:30530842
      assigned_by: EcoCyc
  - go_id: GO:0051787
    label: misfolded protein binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 92
      Archaea: 0
      Bacteria: 1
      Fungi: 22
      Plants: 6
    rate_ratio: 0.0405
    p_value: 1.61e-06
    q_value: 6.09e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P47248
      taxon: NCBITaxon:243273
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002376512|UniProtKB:Q9UBS3
  - go_id: GO:0046475
    label: glycerophospholipid catabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 73
      Archaea: 0
      Bacteria: 1
      Fungi: 22
      Plants: 5
    rate_ratio: 0.0405
    p_value: 1.61e-06
    q_value: 6.09e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09394
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:6304089
      assigned_by: EcoCyc
  - go_id: GO:0030307
    label: positive regulation of cell growth
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 450
      Archaea: 0
      Bacteria: 1
      Fungi: 5
      Plants: 20
    rate_ratio: 0.0405
    p_value: 1.77e-09
    q_value: 9.49e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08365
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:8226627
      assigned_by: EcoCyc
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030307
  - go_id: GO:0032212
    label: positive regulation of telomere maintenance via telomerase
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 139
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0407
    p_value: 6.5e-09
    q_value: 3.26e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q56Y52
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17627276
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0032212
  - go_id: GO:0080183
    label: response to photooxidative stress
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 13
    rate_ratio: 0.0408
    p_value: 1.42e-08
    q_value: 6.87e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XHF7
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8VC33|ensembl:ENSMUSP00000127094
    - protein: UniProtKB:Q8VC33
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25596499
      assigned_by: UniProt
    - protein: UniProtKB:Q96CM4
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8VC33|ensembl:ENSMUSP00000127094
    - protein: UniProtKB:Q96CM4
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8VC33
  - go_id: GO:0008202
    label: steroid metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 443
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 12
    rate_ratio: 0.0411
    p_value: 2.53e-09
    q_value: 1.34e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZCS4
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000672360
  - go_id: GO:0004071
    label: aspartate-ammonia ligase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0412
    p_value: 0.000451
    q_value: 0.00116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08243
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:11372
      gene_review: genes/human/ASNS/ASNS-ai-review.yaml
    - protein: UniProtKB:Q5ZJU3
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:11372
    - protein: UniProtKB:Q61024
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:11372
  - go_id: GO:0043682
    label: P-type divalent copper transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0412
    p_value: 0.000451
    q_value: 0.00116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B1AQ57
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P35670
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2 (Bacteria), on GO:0043682
    - protein: UniProtKB:Q04656
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q64430
      gene_review: genes/human/ATP7A/ATP7A-ai-review.yaml
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2 (Bacteria), on GO:0043682
    - protein: UniProtKB:Q64446
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P35670
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2 (Bacteria), on GO:0043682
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2 (Bacteria), on GO:0043682
  - go_id: GO:0043470
    label: regulation of carbohydrate catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0412
    p_value: 0.000451
    q_value: 0.00116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E1BRR6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:O35114|ensembl:ENSMUSP00000031377
    - protein: UniProtKB:E1BRR6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q14108|ensembl:ENSP00000264896
    - protein: UniProtKB:O35114
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q14108|ensembl:ENSP00000264896
    - protein: UniProtKB:O35114
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18022370
      assigned_by: ARUK-UCL
    - protein: UniProtKB:O35114
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q14108
    - protein: UniProtKB:Q14108
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:O35114|ensembl:ENSMUSP00000031377
      gene_review: genes/human/SCARB2/SCARB2-ai-review.yaml
    - protein: UniProtKB:Q14108
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:18022370
      assigned_by: ARUK-UCL
      gene_review: genes/human/SCARB2/SCARB2-ai-review.yaml
  - go_id: GO:0019866
    label: organelle inner membrane
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0412
    p_value: 0.000451
    q_value: 0.00116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1A0C4
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8WWR8|ensembl:ENSP00000385402
    - protein: UniProtKB:Q8BZL1
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8WWR8|ensembl:ENSP00000385402
    - protein: UniProtKB:Q8BZL1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q8WWR8
    - protein: UniProtKB:Q8BZL1
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8WWR8
    - protein: UniProtKB:Q8WWR8
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:14962670
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0019866
  - go_id: GO:0016793
    label: triphosphoric monoester hydrolase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0412
    p_value: 0.000451
    q_value: 0.00116
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5ZJL9
      taxon: NCBITaxon:9031
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q60710
    - protein: UniProtKB:Q60710
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:29379009
      assigned_by: UniProt
    - protein: UniProtKB:Q9Y3Z3
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q60710|ensembl:ENSMUSP00000059717
  - go_id: GO:0016405
    label: CoA-ligase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 59
      Archaea: 5
      Bacteria: 18
      Fungi: 1
      Plants: 54
    rate_ratio: 0.0413
    p_value: 0.00152
    q_value: 0.00349
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O74419
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000644789|UniProtKB:P76085
  - go_id: GO:0030177
    label: positive regulation of Wnt signaling pathway
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 273
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0414
    p_value: 8.83e-17
    q_value: 8.35e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T779
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0037780|PANTHER:PTN000370137|UniProtKB:Q96SW2
    - protein: UniProtKB:D8TE34
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0037780|PANTHER:PTN000370137|UniProtKB:Q96SW2
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0030177
  - go_id: GO:0000730
    label: DNA recombinase assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 36
      Archaea: 0
      Bacteria: 0
      Fungi: 20
      Plants: 3
    rate_ratio: 0.0414
    p_value: 9.05e-11
    q_value: 5.46e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R902
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001415033|PomBase:SPAC20H4.07|PomBase:SPAC644.14c|PomBase:SPAC8E11.03c|SGD:S000002411
    - protein: UniProtKB:P94102
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001415033|PomBase:SPAC20H4.07|PomBase:SPAC644.14c|PomBase:SPAC8E11.03c|SGD:S000002411
    - protein: UniProtKB:Q39009
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001415033|PomBase:SPAC20H4.07|PomBase:SPAC644.14c|PomBase:SPAC8E11.03c|SGD:S000002411
  - go_id: GO:0070987
    label: error-free translesion synthesis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 4
      Fungi: 20
      Plants: 3
    rate_ratio: 0.0414
    p_value: 9.05e-11
    q_value: 5.46e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A3EWL3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000195725|PANTHER:PTN000117973|PomBase:SPBC1347.01c|SGD:S000005873
    - protein: UniProtKB:D8R5R1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000195725|PANTHER:PTN000117973|PomBase:SPBC1347.01c|SGD:S000005873
    - protein: UniProtKB:D8SFY4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000195725|PANTHER:PTN000117973|PomBase:SPBC1347.01c|SGD:S000005873
  - go_id: GO:0000900
    label: mRNA regulatory element binding translation repressor activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 136
      Archaea: 0
      Bacteria: 3
      Fungi: 6
      Plants: 1
    rate_ratio: 0.0416
    p_value: 1.04e-08
    q_value: 5.09e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FVC1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17322399
      assigned_by: TAIR
      gene_review: genes/ARATH/SVP/SVP-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0000900
  - go_id: GO:1903077
    label: negative regulation of protein localization to plasma membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 136
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0416
    p_value: 1.04e-08
    q_value: 5.09e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O64425
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19234086
      assigned_by: TAIR
  - go_id: GO:0016705
    label: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular
      oxygen
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1518
      Archaea: 2
      Bacteria: 49
      Fungi: 25
      Plants: 830
    rate_ratio: 0.0422
    p_value: 2.03e-17
    q_value: 1.99e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q55080
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001128|InterPro:IPR002397|InterPro:IPR017972|InterPro:IPR036396
    - protein: UniProtKB:Q6M159
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011251|InterPro:IPR036661
  - go_id: GO:0030915
    label: Smc5-Smc6 complex
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 141
      Archaea: 0
      Bacteria: 1
      Fungi: 21
      Plants: 23
    rate_ratio: 0.0424
    p_value: 3.28e-06
    q_value: 1.19e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q188E4
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN008171821
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030915
  - go_id: GO:0007009
    label: plasma membrane organization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 214
      Archaea: 0
      Bacteria: 1
      Fungi: 21
      Plants: 4
    rate_ratio: 0.0424
    p_value: 3.28e-06
    q_value: 1.19e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34789
      taxon: NCBITaxon:224308
      evidence: IMP
      reference: PMID:34777311
      assigned_by: UniProt
  - go_id: GO:0045143
    label: homologous chromosome segregation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 38
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 2
    rate_ratio: 0.0425
    p_value: 3.07e-07
    q_value: 1.28e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JEP5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18318687
      assigned_by: UniProt
    - protein: UniProtKB:F4JP48
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15489296
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0045143
  - go_id: GO:0010314
    label: phosphatidylinositol-5-phosphate binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 103
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 2
    rate_ratio: 0.0425
    p_value: 3.07e-07
    q_value: 1.28e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C5X4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16585509
      assigned_by: TAIR
    - protein: UniProtKB:Q9FG74
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27251533
      assigned_by: UniProt
      gene_review: genes/ARATH/D6PK/D6PK-ai-review.yaml
  - go_id: GO:0009303
    label: rRNA transcription
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 60
      Archaea: 0
      Bacteria: 3
      Fungi: 13
      Plants: 2
    rate_ratio: 0.0425
    p_value: 3.07e-07
    q_value: 1.28e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8H1E7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20877469
      assigned_by: TAIR
    - protein: UniProtKB:Q9FR53
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21266656
      assigned_by: TAIR
  - go_id: GO:0015431
    label: ABC-type glutathione S-conjugate transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 133
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0425
    p_value: 1.66e-08
    q_value: 7.95e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LK64
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:9681016
      assigned_by: TAIR
  - go_id: GO:0031054
    label: pre-miRNA processing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 133
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0425
    p_value: 1.66e-08
    q_value: 7.95e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O04492
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16428603
      assigned_by: UniProt
      gene_review: genes/ARATH/DRB1/DRB1-ai-review.yaml
    - protein: UniProtKB:O04492
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17337628
      assigned_by: UniProt
      gene_review: genes/ARATH/DRB1/DRB1-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0031054
  - go_id: GO:0022407
    label: regulation of cell-cell adhesion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 133
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0425
    p_value: 1.66e-08
    q_value: 7.95e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RBM1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017403
  - go_id: GO:1902555
    label: endoribonuclease complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 82
      Archaea: 4
      Bacteria: 1
      Fungi: 7
      Plants: 3
    rate_ratio: 0.0428
    p_value: 0.000522
    q_value: 0.00132
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QZY1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033555
    - protein: UniProtKB:D8TC13
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033555
    - protein: UniProtKB:Q6AWV1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033555
  - go_id: GO:0004076
    label: biotin synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 7
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0428
    p_value: 0.000522
    q_value: 0.00132
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QXQ4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000540961|PomBase:SPCC1235.02|SGD:S000003518|UniProtKB:P12996|UniProtKB:P9WPQ7
    - protein: UniProtKB:D8QXQ4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024177
    - protein: UniProtKB:D8QXQ4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.8.1.6|EC:2.8.1.6
    - protein: UniProtKB:D8SDT9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000540961|PomBase:SPCC1235.02|SGD:S000003518|UniProtKB:P12996|UniProtKB:P9WPQ7
    - protein: UniProtKB:D8SDT9
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024177
    - protein: UniProtKB:D8SDT9
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.8.1.6|EC:2.8.1.6
    - protein: UniProtKB:P54967
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000540961|PomBase:SPCC1235.02|SGD:S000003518|UniProtKB:P12996|UniProtKB:P9WPQ7
    - protein: UniProtKB:P54967
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024177
    - protein: UniProtKB:P54967
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.8.1.6
    - protein: UniProtKB:P54967
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22060
  - go_id: GO:0008902
    label: hydroxymethylpyrimidine kinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 10
      Fungi: 7
      Plants: 3
    rate_ratio: 0.0428
    p_value: 0.000522
    q_value: 0.00132
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T631
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000466159|SGD:S000005416|SGD:S000006179|UniProtKB:P76422
    - protein: UniProtKB:D8T631
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.49|EC:2.7.1.49
    - protein: UniProtKB:D8T7X1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000466159|SGD:S000005416|SGD:S000006179|UniProtKB:P76422
    - protein: UniProtKB:D8T7X1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.49|EC:2.7.1.49
    - protein: UniProtKB:Q5M731
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000466159|SGD:S000005416|SGD:S000006179|UniProtKB:P76422
    - protein: UniProtKB:Q5M731
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.49
    - protein: UniProtKB:Q5M731
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:23096
  - go_id: GO:0009349
    label: riboflavin synthase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0428
    p_value: 0.000522
    q_value: 0.00132
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SBQ1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002180|InterPro:IPR036467
    - protein: UniProtKB:D8SBQ1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000000683
    - protein: UniProtKB:D8T5Z8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002180|InterPro:IPR036467
    - protein: UniProtKB:D8T5Z8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000000683
    - protein: UniProtKB:O80575
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002180|InterPro:IPR036467
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0009349
  - go_id: GO:0008972
    label: phosphomethylpyrimidine kinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 8
      Fungi: 7
      Plants: 3
    rate_ratio: 0.0428
    p_value: 0.000522
    q_value: 0.00132
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T631
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000466159|SGD:S000005416|SGD:S000006179|UniProtKB:P76422
    - protein: UniProtKB:D8T631
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004399
    - protein: UniProtKB:D8T7X1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000466159|SGD:S000005416|SGD:S000006179|UniProtKB:P76422
    - protein: UniProtKB:D8T7X1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004399
    - protein: UniProtKB:Q5M731
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000466159|SGD:S000005416|SGD:S000006179|UniProtKB:P76422
    - protein: UniProtKB:Q5M731
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004399
  - go_id: GO:0045786
    label: negative regulation of cell cycle
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 264
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0428
    p_value: 3.58e-16
    q_value: 3.25e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GYJ3
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:15037450
      assigned_by: TAIR
    - protein: UniProtKB:Q9LZ78
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26561564
      assigned_by: TAIR
  - go_id: GO:0031396
    label: regulation of protein ubiquitination
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 131
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0432
    p_value: 2.26e-08
    q_value: 1.07e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22286
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22172674
      assigned_by: TAIR
  - go_id: GO:0015128
    label: gluconate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 26
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0432
    p_value: 1.71e-06
    q_value: 6.43e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q92339
      taxon: NCBITaxon:284812
      evidence: IMP
      reference: PMID:10735857
      assigned_by: PomBase
  - go_id: GO:0004407
    label: histone deacetylase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 420
      Archaea: 2
      Bacteria: 1
      Fungi: 20
      Plants: 34
    rate_ratio: 0.0434
    p_value: 8.22e-09
    q_value: 4.08e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39067
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G18520|AGI_LocusCode:AT4G38130|AGI_LocusCode:AT5G61060|AGI_LocusCode:AT5G61070|AGI_LocusCode:AT5G63110|CGD:CAL0000175821|FB:FBgn0015805|FB:FBgn0025825|FB:FBgn0026428|FB:FBgn0041210|MGI:MGI:108086|MGI:MGI:1097691|MGI:MGI:1333752|MGI:MGI:1333784|MGI:MGI:1343091|MGI:MGI:1891835|PANTHER:PTN008143312|PomBase:SPAC3G9.07c|PomBase:SPBC36.05c|PomBase:SPBC800.03|SGD:S000003162|SGD:S000005274|UniProtKB:C8V606|UniProtKB:D6XGM6|UniProtKB:G5EB64|UniProtKB:O15379|UniProtKB:O42227|UniProtKB:P56524|UniProtKB:Q13547|UniProtKB:Q38C74|UniProtKB:Q586J9|UniProtKB:Q7K6A1|UniProtKB:Q92769|UniProtKB:Q969S8|UniProtKB:Q96DB2|UniProtKB:Q9BY41|UniProtKB:Q9UBN7|UniProtKB:Q9UKV0|UniProtKB:Q9UQL6|WB:WBGene00001834|dictyBase:DDB_G0270338
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0004407
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0004407
  - go_id: GO:0005540
    label: hyaluronic acid binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 259
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0437
    p_value: 7.79e-16
    q_value: 6.85e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RL02
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR026203
    - protein: UniProtKB:D8T2S2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR026203
  - go_id: GO:0060326
    label: cell chemotaxis
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 415
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0439
    p_value: 1.06e-08
    q_value: 5.2e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AEX9
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:1091624
      assigned_by: EcoCyc
    - protein: UniProtKB:P0AEX9
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:1429629
      assigned_by: EcoCyc
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:451864 (Dikarya), on GO:0060326
  - go_id: GO:0006879
    label: intracellular iron ion homeostasis
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 499
      Archaea: 1
      Bacteria: 47
      Fungi: 110
      Plants: 80
    rate_ratio: 0.044
    p_value: 4.21e-08
    q_value: 1.94e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LY34
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001519
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006879
  - go_id: GO:0060359
    label: response to ammonium ion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 8
    rate_ratio: 0.0442
    p_value: 1.75e-05
    q_value: 5.73e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P30520
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:D4AEP0|ensembl:ENSRNOP00000005961
    - protein: UniProtKB:P46664
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:D4AEP0|ensembl:ENSRNOP00000005961
  - go_id: GO:0120127
    label: response to zinc ion starvation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 8
    rate_ratio: 0.0442
    p_value: 1.75e-05
    q_value: 5.73e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6ZLZ4
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:68376
    - protein: UniProtKB:Q9EQF5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:68376
  - go_id: GO:0090547
    label: response to low humidity
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 4
    rate_ratio: 0.0442
    p_value: 0.00448
    q_value: 0.00941
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q86BF9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:30230472
      assigned_by: FlyBase
  - go_id: GO:0050017
    label: L-3-cyanoalanine synthase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 4
    rate_ratio: 0.0442
    p_value: 0.00448
    q_value: 0.00941
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O45679
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:24100226
      assigned_by: WB
    - protein: UniProtKB:O45679
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.4.1.9
    - protein: UniProtKB:O45679
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:17821
    - protein: UniProtKB:O45679
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00043396
  - go_id: GO:0072585
    label: xanthosine nucleotidase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 4
    rate_ratio: 0.0442
    p_value: 0.00448
    q_value: 0.00941
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XWN7
      taxon: NCBITaxon:6239
      evidence: EXP
      reference: PMID:12777783
      assigned_by: UniProt
  - go_id: GO:0009268
    label: response to pH
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 93
      Archaea: 0
      Bacteria: 7
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0443
    p_value: 0.000531
    q_value: 0.00134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22932
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17483306
      assigned_by: TAIR
  - go_id: GO:0089718
    label: amino acid import across plasma membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 113
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0443
    p_value: 0.000531
    q_value: 0.00134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84MA5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8618839
      assigned_by: UniProt
    - protein: UniProtKB:Q84MA5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24895758
      assigned_by: UniProt
  - go_id: GO:0110154
    label: RNA decapping
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 12
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0443
    p_value: 0.000531
    q_value: 0.00134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8RY73
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31449356
      assigned_by: TAIR
  - go_id: GO:1990169
    label: stress response to copper ion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0443
    p_value: 0.000531
    q_value: 0.00134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FJ47
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:10380810
      assigned_by: UniProt
  - go_id: GO:0015795
    label: sorbitol transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0443
    p_value: 0.000531
    q_value: 0.00134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VZ80
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015576
  - go_id: GO:0019146
    label: arabinose-5-phosphate isomerase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0443
    p_value: 0.000531
    q_value: 0.00134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9M1T1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:5.3.1.13
    - protein: UniProtKB:Q9M1T1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:23104
  - go_id: GO:0001664
    label: G protein-coupled receptor binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 382
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0444
    p_value: 6.55e-23
    q_value: 8.94e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QR00
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002976
    - protein: UniProtKB:D8QR00
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001591782
    - protein: UniProtKB:D8R7Y3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002976
    - protein: UniProtKB:D8R7Y3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001591782
    - protein: UniProtKB:P18064
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002976
  - go_id: GO:0000920
    label: septum digestion after cytokinesis
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 3
      Fungi: 60
      Plants: 0
    rate_ratio: 0.0445
    p_value: 2.94e-16
    q_value: 2.68e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P37690
      taxon: NCBITaxon:83333
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001092783|UniProtKB:P37690
    - protein: UniProtKB:P37690
      taxon: NCBITaxon:83333
      evidence: IGI
      reference: PMID:19525345
      assigned_by: EcoliWiki
      with_from: EcoliWiki:NlpD
    - protein: UniProtKB:P37690
      taxon: NCBITaxon:83333
      evidence: IGI
      reference: PMID:19525345
      assigned_by: EcoliWiki
      with_from: EcoliWiki:nlpD|EcoliWiki:yebA|EcoliWiki:ygeR
    - protein: UniProtKB:P37690
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:19525345
      assigned_by: EcoliWiki
    - protein: UniProtKB:P46889
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:9294448
      assigned_by: EcoliWiki
    - protein: UniProtKB:Q8ZL55
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001092783|UniProtKB:P37690
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:33208 (Metazoa), on GO:0000920
    - never_in_taxon NCBITaxon:554915 (Amoebozoa), on GO:0000920
  - go_id: GO:0006665
    label: sphingolipid metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 297
      Archaea: 0
      Bacteria: 2
      Fungi: 40
      Plants: 55
    rate_ratio: 0.0445
    p_value: 4.17e-11
    q_value: 2.59e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:H9L4C2
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001139
    - protein: UniProtKB:Q45070
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001139
  - go_id: GO:0090316
    label: positive regulation of intracellular protein transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 127
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0445
    p_value: 4.21e-08
    q_value: 1.94e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5PNU3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20543027
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0090316
  - go_id: GO:0016581
    label: NuRD complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 253
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0447
    p_value: 1.98e-15
    q_value: 1.7e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4PSK1
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:O95983
    - protein: UniProtKB:Q8LA53
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9UBB5
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0016581
  - go_id: GO:0009847
    label: spore germination
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 25
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0449
    p_value: 3.13e-06
    q_value: 1.13e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39001
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:21059190
      assigned_by: SGD
  - go_id: GO:0005319
    label: lipid carrier activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 193
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 80
    rate_ratio: 0.0452
    p_value: 1.22e-07
    q_value: 5.39e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q06833
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:28011845
      assigned_by: SGD
  - go_id: GO:0006303
    label: double-strand break repair via nonhomologous end joining
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 332
      Archaea: 0
      Bacteria: 3
      Fungi: 59
      Plants: 36
    rate_ratio: 0.0453
    p_value: 5.94e-16
    q_value: 5.28e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZAQ7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR006164
    - protein: UniProtKB:A0A0H2ZAQ7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000058569
    - protein: UniProtKB:O34398
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001627042|UniProtKB:P9WNV3
    - protein: UniProtKB:O34859
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR006164
    - protein: UniProtKB:O34859
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000058569
    - protein: UniProtKB:O34859
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027924
  - go_id: GO:0060090
    label: molecular adaptor activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 1368
      Archaea: 1
      Bacteria: 14
      Fungi: 106
      Plants: 92
    rate_ratio: 0.0456
    p_value: 8.61e-08
    q_value: 3.87e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LWJ5
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR037587
  - go_id: GO:0017101
    label: aminoacyl-tRNA synthetase multienzyme complex
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 299
      Archaea: 8
      Bacteria: 2
      Fungi: 11
      Plants: 16
    rate_ratio: 0.046
    p_value: 2.27e-05
    q_value: 7.27e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P47525
      taxon: NCBITaxon:243273
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0005674|MGI:MGI:97838|PANTHER:PTN000155236|UniProtKB:P07814
    - protein: UniProtKB:Q18CD7
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN008106982
  - go_id: GO:0018111
    label: methionine racemase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.046
    p_value: 0.0051
    q_value: 0.0105
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P32960
      taxon: NCBITaxon:224308
      evidence: EXP
      reference: PMID:28894939
      assigned_by: UniProt
    - protein: UniProtKB:P32960
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12492
  - go_id: GO:0000444
    label: MIS12/MIND type complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 60
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 2
    rate_ratio: 0.046
    p_value: 1.23e-06
    q_value: 4.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JT58
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007128
    - protein: UniProtKB:Q2V0Z5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001427121|PomBase:SPBC409.04c|SGD:S000000032|UniProtKB:Q9H081
    - protein: UniProtKB:Q2V0Z5
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9H081
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0000444
  - go_id: GO:0098703
    label: calcium ion import across plasma membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 125
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 2
    rate_ratio: 0.046
    p_value: 1.23e-06
    q_value: 4.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RLL1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024338
    - protein: UniProtKB:D8RN34
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024338
  - go_id: GO:0042719
    label: mitochondrial intermembrane space chaperone complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 68
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 2
    rate_ratio: 0.046
    p_value: 1.23e-06
    q_value: 4.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QP64
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1353436|PANTHER:PTN004407763|SGD:S000007256|UniProtKB:Q9Y5J6|UniProtKB:Q9Y5J7
    - protein: UniProtKB:Q9XGX9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1353436|PANTHER:PTN004407763|SGD:S000007256|UniProtKB:Q9Y5J6|UniProtKB:Q9Y5J7
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0042719
  - go_id: GO:0010833
    label: telomere maintenance via telomere lengthening
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 53
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 2
    rate_ratio: 0.046
    p_value: 1.23e-06
    q_value: 4.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D0EL35
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1916214|PANTHER:PTN001804660
    - protein: UniProtKB:D8QYM5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1916214|PANTHER:PTN001804660
  - go_id: GO:1990809
    label: endoplasmic reticulum tubular network membrane organization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 52
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 2
    rate_ratio: 0.046
    p_value: 1.23e-06
    q_value: 4.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S6Z2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001398562|PomBase:SPBC1539.04
    - protein: UniProtKB:D8T7G1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001398562|PomBase:SPBC1539.04
  - go_id: GO:0015810
    label: aspartate transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 92
      Archaea: 0
      Bacteria: 1
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P92934
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:12148530
      assigned_by: TAIR
  - go_id: GO:0110078
    label: TTT Hsp90 cochaperone complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 16
      Archaea: 0
      Bacteria: 0
      Fungi: 12
      Plants: 2
    rate_ratio: 0.046
    p_value: 1.23e-06
    q_value: 4.73e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RP92
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018870
    - protein: UniProtKB:D8SM01
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018870
  - go_id: GO:0090266
    label: regulation of mitotic cell cycle spindle assembly checkpoint
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 48
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4K991
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR026182
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0090266
  - go_id: GO:0008126
    label: acetylesterase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 27
      Archaea: 0
      Bacteria: 3
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9STM6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28510842
      assigned_by: TAIR
  - go_id: GO:0042770
    label: signal transduction in response to DNA damage
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 91
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FV70
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30427087
      assigned_by: TAIR
  - go_id: GO:0005641
    label: nuclear envelope lumen
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 57
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J1U4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33751090
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0005641
  - go_id: GO:0047681
    label: aryl-alcohol dehydrogenase (NADP+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 1
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q02972
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:11038530
      assigned_by: TAIR
  - go_id: GO:0033120
    label: positive regulation of RNA splicing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 90
      Archaea: 0
      Bacteria: 1
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4K2E9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25384462
      assigned_by: UniProt
  - go_id: GO:0120542
    label: ethanol dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 6
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P06525
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:38308388
      assigned_by: UniProt
      gene_review: genes/ARATH/ADH1/ADH1-ai-review.yaml
    - protein: UniProtKB:P06525
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:25290
      gene_review: genes/ARATH/ADH1/ADH1-ai-review.yaml
  - go_id: GO:0061692
    label: cellular detoxification of hydrogen peroxide
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9T0H4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30911018
      assigned_by: TAIR
  - go_id: GO:0006642
    label: triglyceride mobilization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 33
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SKP6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20097871
      assigned_by: TAIR
  - go_id: GO:0043633
    label: polyadenylation-dependent RNA catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 3
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A9LLI7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18285452
      assigned_by: UniProt
  - go_id: GO:0042762
    label: regulation of sulfur metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 1
    rate_ratio: 0.046
    p_value: 0.00117
    q_value: 0.00275
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O23116
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17114350
      assigned_by: TAIR
  - go_id: GO:0004713
    label: protein tyrosine kinase activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 2119
      Archaea: 1
      Bacteria: 18
      Fungi: 30
      Plants: 124
    rate_ratio: 0.0467
    p_value: 2.53e-08
    q_value: 1.19e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4JAG2
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:10596
  - go_id: GO:0009063
    label: amino acid catabolic process
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 125
      Archaea: 2
      Bacteria: 24
      Fungi: 1
      Plants: 5
    rate_ratio: 0.0468
    p_value: 5.69e-06
    q_value: 1.98e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P43634
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:8889513
      assigned_by: SGD
  - go_id: GO:0120009
    label: intermembrane lipid transfer
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 339
      Archaea: 0
      Bacteria: 2
      Fungi: 38
      Plants: 64
    rate_ratio: 0.0469
    p_value: 1.71e-10
    q_value: 1.01e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P43671
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:28388411
      assigned_by: EcoCyc
    - protein: UniProtKB:P76272
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:28388411
      assigned_by: EcoCyc
  - go_id: GO:0052553
    label: symbiont-mediated perturbation of host immune response
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 19
      Plants: 0
    rate_ratio: 0.0469
    p_value: 1.35e-05
    q_value: 4.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0CE12
      taxon: NCBITaxon:99287
      evidence: EXP
      reference: PMID:23935490
      assigned_by: SigSci
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:33090 (Viridiplantae), on GO:0052553
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0052553
    - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0052553
  - go_id: GO:0042799
    label: histone H4K20 methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 120
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0471
    p_value: 1.25e-07
    q_value: 5.48e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RAW7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0011474|PANTHER:PTN002920257|UniProtKB:Q9NQR1|WB:WBGene00004781
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0042799
  - go_id: GO:0047496
    label: vesicle transport along microtubule
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 119
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0475
    p_value: 1.46e-07
    q_value: 6.33e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VWI7
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:11701879
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0047496
  - go_id: GO:0009931
    label: calcium-dependent protein serine/threonine kinase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 76
    rate_ratio: 0.0476
    p_value: 3.1e-07
    q_value: 1.29e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P36003
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G17290|AGI_LocusCode:AT3G57530|AGI_LocusCode:AT5G04870|PANTHER:PTN000681419|UniProtKB:A0A5K1K8H0|UniProtKB:P53682|UniProtKB:P62344|UniProtKB:Q0D715|UniProtKB:Q53P85|UniProtKB:Q8IBS5|UniProtKB:Q8ICR0
  - go_id: GO:0034214
    label: protein hexamerization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 84
      Archaea: 0
      Bacteria: 13
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0478
    p_value: 9.44e-07
    q_value: 3.68e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P46637
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:32754173
      assigned_by: UniProt
      gene_review: genes/ARATH/ARGAH1/ARGAH1-ai-review.yaml
    - protein: UniProtKB:Q9LQF2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:32134001
      assigned_by: UniProt
  - go_id: GO:1990238
    label: double-stranded DNA endonuclease activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 13
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0478
    p_value: 9.44e-07
    q_value: 3.68e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C9G4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23620482
      assigned_by: UniProt
    - protein: UniProtKB:Q9SXA6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23620482
      assigned_by: UniProt
  - go_id: GO:0033212
    label: iron import into cell
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 13
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0478
    p_value: 9.44e-07
    q_value: 3.68e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HVS0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:31413196
      assigned_by: TAIR
    - protein: UniProtKB:F4IDY5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:31413196
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0033212
  - go_id: GO:0033011
    label: perinuclear theca
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 117
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0483
    p_value: 1.98e-07
    q_value: 8.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L706
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34504049
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0033011
  - go_id: GO:0036158
    label: outer dynein arm assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 117
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0483
    p_value: 1.98e-07
    q_value: 8.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RLI1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1914935|PANTHER:PTN002925607|UniProtKB:Q8WXU2
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0036158
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0036158
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0036158
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0036158
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0036158
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0036158
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0036158
  - go_id: GO:0045937
    label: positive regulation of phosphate metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0ACI8R7Y5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028182
    - protein: UniProtKB:P12931
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028182
      gene_review: genes/human/SRC/SRC-ai-review.yaml
  - go_id: GO:0043097
    label: pyrimidine nucleoside salvage
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O00142
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-73614
      assigned_by: Reactome
      gene_review: genes/human/TK2/TK2-ai-review.yaml
    - protein: UniProtKB:Q9NWZ5
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-73614
      assigned_by: Reactome
      gene_review: genes/human/UCKL1/UCKL1-ai-review.yaml
  - go_id: GO:0005476
    label: carnitine:O-acyl-L-carnitine antiporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O43772
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:9399886
      assigned_by: Reactome
      gene_review: genes/human/SLC25A20/SLC25A20-ai-review.yaml
    - protein: UniProtKB:O43772
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-9971094
      assigned_by: Reactome
      gene_review: genes/human/SLC25A20/SLC25A20-ai-review.yaml
    - protein: UniProtKB:Q9Z2Z6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:O43772
  - go_id: GO:1905325
    label: regulation of meiosis I spindle assembly checkpoint
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O95229
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9CQU5
    - protein: UniProtKB:Q9CQU5
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:26486467
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1905325
  - go_id: GO:0098718
    label: serine import across plasma membrane
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O35874
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:11030592
      assigned_by: MGI
    - protein: UniProtKB:Q5SSP3
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:11030592
      assigned_by: MGI
  - go_id: GO:0070676
    label: intralumenal vesicle formation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AHN5
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q96NA2|ensembl:ENSP00000301336
    - protein: UniProtKB:Q5ND29
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q96NA2|ensembl:ENSP00000301336
  - go_id: GO:0033750
    label: ribosome localization
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1ZAB5
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:26834020
      assigned_by: FlyBase
      with_from: FB:FBgn0014026
    - protein: UniProtKB:Q9VEP0
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:37047316
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0033750
  - go_id: GO:0000992
    label: RNA polymerase III cis-regulatory region sequence-specific DNA binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P20227
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00092969
    - protein: UniProtKB:Q27896
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00092969
  - go_id: GO:0032033
    label: myosin II light chain binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9NB04
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:23128243
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VJ14
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:18216171
      assigned_by: FlyBase
      with_from: FB:FBgn0003514
  - go_id: GO:1904688
    label: regulation of cytoplasmic translational initiation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D0Z5N4
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:22719267
      assigned_by: UniProt
      with_from: UniProtKB:O44512|UniProtKB:P48376
      gene_review: genes/worm/gcn-2/gcn-2-ai-review.yaml
    - protein: UniProtKB:D0Z5N4
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:23692540
      assigned_by: UniProt
      gene_review: genes/worm/gcn-2/gcn-2-ai-review.yaml
    - protein: UniProtKB:Q19192
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:22719267
      assigned_by: UniProt
      with_from: UniProtKB:D0Z5N4,UniProtKB:Q27497
      gene_review: genes/worm/pek-1/pek-1-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1904688
  - go_id: GO:0048308
    label: organelle inheritance
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.0244
    q_value: 0.0428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:H2L067
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:8861905
      assigned_by: WB
      with_from: WB:WBVar00275499
    - protein: UniProtKB:Q95R07
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:8861905
      assigned_by: WB
      with_from: WB:WBVar00275499
  - go_id: GO:0061573
    label: actin filament bundle retrograde transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0MZ66
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0MZ67
    - protein: UniProtKB:Q8K2Q9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1311558
    - protein: UniProtKB:Q8K2Q9
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0MZ67
    - protein: UniProtKB:Q8SX68
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:31164339
      assigned_by: UniProt
  - go_id: GO:0120124
    label: membrane fusion priming complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O15498
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:38340317
      assigned_by: ComplexPortal
    - protein: UniProtKB:O95721
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:38340317
      assigned_by: ComplexPortal
    - protein: UniProtKB:P56962
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:38340317
      assigned_by: ComplexPortal
  - go_id: GO:0000481
    label: maturation of 5S rRNA
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 7
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O01524
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000365724|SGD:S000005835
    - protein: UniProtKB:O43290
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000365724|SGD:S000005835
    - protein: UniProtKB:Q9Z315
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000365724|SGD:S000005835
  - go_id: GO:2000784
    label: positive regulation of establishment of cell polarity regulating cell shape
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A494B9A7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:69285
    - protein: UniProtKB:P18760
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P45592|ensembl:ENSRNOP00000093902
    - protein: UniProtKB:P18760
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:69285
    - protein: UniProtKB:P23528
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P45592|ensembl:ENSRNOP00000093902
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:2000784
  - go_id: GO:0001156
    label: TFIIIC-class transcription factor complex binding
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F1NUX4
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P42345|ensembl:ENSP00000354558
    - protein: UniProtKB:P42345
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20543138
      assigned_by: UniProt
    - protein: UniProtKB:Q9JLN9
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P42345|ensembl:ENSP00000354558
      gene_review: genes/mouse/Mtor/Mtor-ai-review.yaml
    - protein: UniProtKB:Q9JLN9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P42345
      gene_review: genes/mouse/Mtor/Mtor-ai-review.yaml
  - go_id: GO:0000247
    label: C-8 sterol isomerase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 5
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2AC29
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:8798407
      assigned_by: MGI
    - protein: UniProtKB:A2AC29
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10391218
      assigned_by: MGI
      with_from: MGI:MGI:1857832
    - protein: UniProtKB:A2AC29
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:620957
    - protein: UniProtKB:P70245
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G20050|MGI:MGI:107822|PANTHER:PTN000368006|RGD:620957
    - protein: UniProtKB:P70245
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:8798407
      assigned_by: MGI
    - protein: UniProtKB:P70245
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9JJ46|ensembl:ENSRNOP00000007015
    - protein: UniProtKB:P70245
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10391218
      assigned_by: MGI
      with_from: MGI:MGI:1857832
    - protein: UniProtKB:P70245
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:620957
    - protein: UniProtKB:Q15125
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G20050|MGI:MGI:107822|PANTHER:PTN000368006|RGD:620957
      gene_review: genes/human/EBP/EBP-ai-review.yaml
    - protein: UniProtKB:Q15125
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P70245|ensembl:ENSMUSP00000033509
      gene_review: genes/human/EBP/EBP-ai-review.yaml
    - protein: UniProtKB:Q15125
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9JJ46|ensembl:ENSRNOP00000007015
      gene_review: genes/human/EBP/EBP-ai-review.yaml
    - protein: UniProtKB:Q15125
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9JJ46
      gene_review: genes/human/EBP/EBP-ai-review.yaml
  - go_id: GO:0070274
    label: RES complex
    aspect: CC
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8TAD8
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:39068178
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q9BRD0
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: PMID:15565172
      assigned_by: BHF-UCL
      with_from: UniProtKB:P46947
    - protein: UniProtKB:Q9BRD0
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:39068178
      assigned_by: ComplexPortal
    - protein: UniProtKB:Q9Y388
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:39068178
      assigned_by: ComplexPortal
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070274
  - go_id: GO:1902985
    label: mitotic pre-replicative complex assembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XQ29
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9H211|ensembl:ENSP00000301019
    - protein: UniProtKB:Q8R4E9
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9H211|ensembl:ENSP00000301019
    - protein: UniProtKB:Q8R4E9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9H211
    - protein: UniProtKB:Q9H211
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:11125146
      assigned_by: UniProt
      gene_review: genes/human/CDT1/CDT1-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1902985
  - go_id: GO:1904291
    label: positive regulation of mitotic DNA damage checkpoint
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2ASW6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NYL2
    - protein: UniProtKB:Q9ESL4
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NYL2|ensembl:ENSP00000364361
    - protein: UniProtKB:Q9ESL4
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NYL2
    - protein: UniProtKB:Q9ESL4
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9NYL2
    - protein: UniProtKB:Q9NYL2
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:15342622
      assigned_by: UniProt
      gene_review: genes/human/MAP3K20/MAP3K20-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1904291
  - go_id: GO:0010610
    label: regulation of mRNA stability involved in response to stress
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1A3J6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NZI8|ensembl:ENSP00000290341
    - protein: UniProtKB:O88477
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NZI8|ensembl:ENSP00000290341
    - protein: UniProtKB:O88477
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NZI8
    - protein: UniProtKB:O88477
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9NZI8
    - protein: UniProtKB:Q9NZI8
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:17101699
      assigned_by: UniProt
  - go_id: GO:0140665
    label: ATP-dependent H3-H4 histone complex chaperone activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XAB0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9UER7|ensembl:ENSP00000363668
    - protein: UniProtKB:O35613
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:20651253
      assigned_by: GO_Central
    - protein: UniProtKB:Q9UER7
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20504901
      assigned_by: GO_Central
    - protein: UniProtKB:Q9UER7
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20651253
      assigned_by: GO_Central
  - go_id: GO:0045895
    label: positive regulation of mating-type specific transcription, DNA-templated
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4J1L1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2074
    - protein: UniProtKB:F6TX41
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2074
    - protein: UniProtKB:P30561
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2074
  - go_id: GO:0046461
    label: neutral lipid catabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1L1SQT9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3009
    - protein: UniProtKB:A0A1L1SRU8
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3009
    - protein: UniProtKB:P27656
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3009
  - go_id: GO:0140129
    label: histone H3K56ac reader activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G3UYF2
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:23798425
      assigned_by: MGI
    - protein: UniProtKB:G3UZG9
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:23798425
      assigned_by: MGI
    - protein: UniProtKB:P20263
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:23798425
      assigned_by: MGI
  - go_id: GO:0001962
    label: alpha-1,3-galactosyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P38649
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2307241
    - protein: UniProtKB:Q3V1N9
      taxon: NCBITaxon:10090
      evidence: IGI
      reference: PMID:22875802
      assigned_by: MGI
      with_from: MGI:MGI:1347344
    - protein: UniProtKB:Q3V1N9
      taxon: NCBITaxon:10090
      evidence: IGI
      reference: PMID:22875802
      assigned_by: MGI
      with_from: MGI:MGI:3512453
    - protein: UniProtKB:Q3V1N9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000008
      assigned_by: MGI
      with_from: UniProtKB:A0A4Z3
    - protein: UniProtKB:Z4YLB0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2307241
  - go_id: GO:0051229
    label: meiotic spindle disassembly
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0488
    p_value: 0.00363
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EGK8
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:17218259
      assigned_by: WB
    - protein: UniProtKB:O44740
      taxon: NCBITaxon:6239
      evidence: NAS
      reference: PMID:10809666
      assigned_by: ComplexPortal
    - protein: UniProtKB:P34808
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:23918937
      assigned_by: WB
    - protein: UniProtKB:P34808
      taxon: NCBITaxon:6239
      evidence: NAS
      reference: PMID:10809666
      assigned_by: ComplexPortal
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051229
  - go_id: GO:0006816
    label: calcium ion transport
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1116
      Archaea: 0
      Bacteria: 3
      Fungi: 16
      Plants: 45
    rate_ratio: 0.049
    p_value: 8.8e-22
    q_value: 1.14e-20
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O31539
      taxon: NCBITaxon:224308
      evidence: IDA
      reference: PMID:30930064
      assigned_by: FlyBase
    - protein: UniProtKB:O34431
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005782
    - protein: UniProtKB:O34840
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004798
  - go_id: GO:0019395
    label: fatty acid oxidation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 115
      Archaea: 0
      Bacteria: 3
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0492
    p_value: 2.7e-07
    q_value: 1.13e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LZ31
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19120447
      assigned_by: UniProt
  - go_id: GO:0051056
    label: regulation of small GTPase mediated signal transduction
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 829
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0494
    p_value: 1.06e-14
    q_value: 8.69e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PMB6
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000331|InterPro:IPR035974
    - protein: UniProtKB:Q9UUG9
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000331|InterPro:IPR035974
  - go_id: GO:0005940
    label: septin ring
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 48
      Archaea: 0
      Bacteria: 2
      Fungi: 36
      Plants: 0
    rate_ratio: 0.0495
    p_value: 6.96e-10
    q_value: 3.87e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34894
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010379
    - protein: UniProtKB:P47637
      taxon: NCBITaxon:243273
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010379
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005940
  - go_id: GO:2000042
    label: negative regulation of double-strand break repair via homologous recombination
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 228
      Archaea: 0
      Bacteria: 3
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0496
    p_value: 9.46e-14
    q_value: 7.22e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8AN39
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27760121
      assigned_by: TAIR
    - protein: UniProtKB:F4HW22
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27760121
      assigned_by: TAIR
  - go_id: GO:0045930
    label: negative regulation of mitotic cell cycle
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 114
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0496
    p_value: 3.15e-07
    q_value: 1.31e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SZF7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G37650|PANTHER:PTN001587390
      gene_review: genes/ARATH/SHR/SHR-ai-review.yaml
    - protein: UniProtKB:Q9SZF7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20739610
      assigned_by: TAIR
      gene_review: genes/ARATH/SHR/SHR-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0045930
  - go_id: GO:0004064
    label: arylesterase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 114
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0496
    p_value: 3.15e-07
    q_value: 1.31e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SYF0
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19146828
      assigned_by: TAIR
  - go_id: GO:0043547
    label: positive regulation of GTPase activity
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 366
      Archaea: 0
      Bacteria: 1
      Fungi: 1
      Plants: 10
    rate_ratio: 0.0498
    p_value: 1.29e-07
    q_value: 5.66e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A8H6
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:20434458
      assigned_by: EcoCyc
  - go_id: GO:0097020
    label: COPII receptor activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 12
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 2
    rate_ratio: 0.0502
    p_value: 4.91e-06
    q_value: 1.72e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RTD3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000321972|SGD:S000001224
    - protein: UniProtKB:D8RTD3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007277
    - protein: UniProtKB:D8SQS8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000321972|SGD:S000001224
    - protein: UniProtKB:D8SQS8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007277
  - go_id: GO:1990822
    label: basic amino acid transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 14
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 2
    rate_ratio: 0.0502
    p_value: 4.91e-06
    q_value: 1.72e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q39134
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015174
    - protein: UniProtKB:Q8GUM3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015174
  - go_id: GO:0030332
    label: cyclin binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 174
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 2
    rate_ratio: 0.0502
    p_value: 4.91e-06
    q_value: 1.72e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q2V419
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:11432958
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G27960
    - protein: UniProtKB:Q9LW36
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001585923|UniProtKB:Q7Z6J8
  - go_id: GO:0034067
    label: protein localization to Golgi apparatus
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 107
      Archaea: 0
      Bacteria: 1
      Fungi: 11
      Plants: 2
    rate_ratio: 0.0502
    p_value: 4.91e-06
    q_value: 1.72e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QTY2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000196303|SGD:S000005972|UniProtKB:Q13795
    - protein: UniProtKB:D8RJP1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000196303|SGD:S000005972|UniProtKB:Q13795
  - go_id: GO:0140469
    label: GCN2-mediated signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 2
    rate_ratio: 0.0502
    p_value: 4.91e-06
    q_value: 1.72e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T3H7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1098233|PANTHER:PTN000418656|SGD:S000000655
    - protein: UniProtKB:D8TA44
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1098233|PANTHER:PTN000418656|SGD:S000000655
  - go_id: GO:0048532
    label: anatomical structure arrangement
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 7
    rate_ratio: 0.0505
    p_value: 9.39e-05
    q_value: 0.000273
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6WAS0
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20016102
      assigned_by: MGI
      with_from: MGI:MGI:2663662
    - protein: UniProtKB:F6WAS0
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20016102
      assigned_by: MGI
      with_from: MGI:MGI:2663669
    - protein: UniProtKB:P63001
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20016102
      assigned_by: MGI
      with_from: MGI:MGI:2663662
    - protein: UniProtKB:P63001
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20016102
      assigned_by: MGI
      with_from: MGI:MGI:2663669
  - go_id: GO:0120531
    label: prenyl diphosphate synthase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 7
    rate_ratio: 0.0505
    p_value: 9.39e-05
    q_value: 0.000273
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V9Z3
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:20889762
      assigned_by: FlyBase
    - protein: UniProtKB:Q9V9Z3
      taxon: NCBITaxon:7227
      evidence: TAS
      reference: PMID:39864756
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VP87
      taxon: NCBITaxon:7227
      evidence: TAS
      reference: PMID:39864756
      assigned_by: FlyBase
  - go_id: GO:0051924
    label: regulation of calcium ion transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 222
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.051
    p_value: 2.39e-13
    q_value: 1.78e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HX37
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:37995686
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G14400
    - protein: UniProtKB:Q9FLJ8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24769480
      assigned_by: TAIR
  - go_id: GO:0006720
    label: isoprenoid metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 111
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.051
    p_value: 5.01e-07
    q_value: 2.03e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q67ZM7
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:21395888
      assigned_by: TAIR
  - go_id: GO:0006649
    label: phospholipid transfer to membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 111
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.051
    p_value: 5.01e-07
    q_value: 2.03e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9S7I3
      taxon: NCBITaxon:3702
      evidence: NAS
      reference: PMID:10940464
      assigned_by: TAIR
  - go_id: GO:0035770
    label: ribonucleoprotein granule
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 111
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.051
    p_value: 5.01e-07
    q_value: 2.03e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VZE7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1913837|PANTHER:PTN000477113|UniProtKB:Q7L8L6|UniProtKB:Q9NYY8
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0035770
  - go_id: GO:0019262
    label: N-acetylneuraminate catabolic process
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 56
      Archaea: 2
      Bacteria: 22
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0511
    p_value: 1.88e-05
    q_value: 6.09e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q04802
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000138938|UniProtKB:P0A759
  - go_id: GO:0006091
    label: generation of precursor metabolites and energy
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 100
      Archaea: 0
      Bacteria: 22
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0511
    p_value: 1.88e-05
    q_value: 6.09e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9UUE1
      taxon: NCBITaxon:284812
      evidence: NAS
      reference: GO_REF:0000051
      assigned_by: PomBase
      gene_review: genes/SCHPO/pyr1/pyr1-ai-review.yaml
  - go_id: GO:0004760
    label: L-serine:pyruvate transaminase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 26
      Archaea: 4
      Bacteria: 3
      Fungi: 1
      Plants: 5
    rate_ratio: 0.0517
    p_value: 0.00743
    q_value: 0.0147
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P43567
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G13360|FB:FBgn0014031|PANTHER:PTN000475663|RGD:2073|UniProtKB:P21549|UniProtKB:Q9X1C0
      gene_review: genes/yeast/AGX1/AGX1-ai-review.yaml
  - go_id: GO:0015886
    label: heme transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 81
      Archaea: 0
      Bacteria: 18
      Fungi: 13
      Plants: 3
    rate_ratio: 0.0517
    p_value: 6.84e-09
    q_value: 3.43e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IL76
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003557
    - protein: UniProtKB:F4IL90
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003567|InterPro:IPR003569
    - protein: UniProtKB:F4IMA2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003557
  - go_id: GO:0042167
    label: heme catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 63
      Archaea: 0
      Bacteria: 6
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0517
    p_value: 0.00197
    q_value: 0.00442
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LDU1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33284325
      assigned_by: TAIR
  - go_id: GO:0006218
    label: uridine catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 6
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0517
    p_value: 0.00197
    q_value: 0.00442
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SJM7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G36310|PANTHER:PTN000266727|SGD:S000002808
    - protein: UniProtKB:Q9SJM7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19293370
      assigned_by: TAIR
  - go_id: GO:1903424
    label: fluoride transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 6
      Archaea: 1
      Bacteria: 6
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0517
    p_value: 0.00197
    q_value: 0.00442
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8RYE2
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:28472134
      assigned_by: TAIR
      with_from: SGD:S000005917,SGD:S000006200
  - go_id: GO:0015882
    label: L-ascorbic acid transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 9
      Archaea: 0
      Bacteria: 6
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0517
    p_value: 0.00197
    q_value: 0.00442
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GX78
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25557369
      assigned_by: TAIR
  - go_id: GO:0015415
    label: ATPase-coupled phosphate ion transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 6
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0517
    p_value: 0.00197
    q_value: 0.00442
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9S735
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22578268
      assigned_by: TAIR
  - go_id: GO:0035859
    label: Seh1-associated complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 47
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 3
    rate_ratio: 0.0518
    p_value: 2.28e-08
    q_value: 1.08e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RPE9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033247|PANTHER:PTN000111887|PomBase:SPAC15F9.02|SGD:S000003068|UniProtKB:Q96EE3
    - protein: UniProtKB:D8SM57
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033247|PANTHER:PTN000111887|PomBase:SPAC15F9.02|SGD:S000003068|UniProtKB:Q96EE3
    - protein: UniProtKB:Q93VR9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033247|PANTHER:PTN000111887|PomBase:SPAC15F9.02|SGD:S000003068|UniProtKB:Q96EE3
  - go_id: GO:0005353
    label: fructose transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 36
      Archaea: 0
      Bacteria: 0
      Fungi: 16
      Plants: 3
    rate_ratio: 0.0518
    p_value: 2.28e-08
    q_value: 1.08e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84WN3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23583552
      assigned_by: UniProt
    - protein: UniProtKB:Q8L6Z8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17284600
      assigned_by: TAIR
    - protein: UniProtKB:Q9LUR4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:24028846
      assigned_by: UniProt
  - go_id: GO:0031435
    label: mitogen-activated protein kinase kinase kinase binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 109
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0519
    p_value: 6.82e-07
    q_value: 2.71e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FJV0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:30185442
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G08500
  - go_id: GO:0030599
    label: pectinesterase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 124
    rate_ratio: 0.052
    p_value: 2.58e-12
    q_value: 1.79e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P46130
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000070
    - protein: UniProtKB:Q8ZQR3
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000070
  - go_id: GO:0004725
    label: protein tyrosine phosphatase activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1905
      Archaea: 1
      Bacteria: 12
      Fungi: 45
      Plants: 95
    rate_ratio: 0.052
    p_value: 1.96e-07
    q_value: 8.37e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4JB88
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000242
  - go_id: GO:0008574
    label: plus-end-directed microtubule motor activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 155
      Archaea: 0
      Bacteria: 1
      Fungi: 17
      Plants: 14
    rate_ratio: 0.0524
    p_value: 5.51e-05
    q_value: 0.000167
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q189D3
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000649234
  - go_id: GO:0032880
    label: regulation of protein localization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 640
      Archaea: 0
      Bacteria: 2
      Fungi: 34
      Plants: 10
    rate_ratio: 0.0524
    p_value: 2.82e-09
    q_value: 1.48e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A8M6
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000031377
    - protein: UniProtKB:P67605
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000031377
  - go_id: GO:0035825
    label: homologous recombination
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 45
      Archaea: 0
      Bacteria: 1
      Fungi: 17
      Plants: 21
    rate_ratio: 0.0524
    p_value: 5.51e-05
    q_value: 0.000167
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A7G6
      taxon: NCBITaxon:83333
      evidence: TAS
      reference: PMID:10585965
      assigned_by: EcoCyc
  - go_id: GO:0004723
    label: calcium-dependent protein serine/threonine phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 108
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0524
    p_value: 7.96e-07
    q_value: 3.13e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O81223
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:9632394
      assigned_by: TAIR
      gene_review: genes/ARATH/CBL4/CBL4-ai-review.yaml
  - go_id: GO:0001935
    label: endothelial cell proliferation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 108
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0524
    p_value: 7.96e-07
    q_value: 3.13e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6R053
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23911125
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0001935
  - go_id: GO:0052629
    label: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 215
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0526
    p_value: 7.01e-13
    q_value: 5.09e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J3T8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19901554
      assigned_by: TAIR
    - protein: UniProtKB:F4J3T8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22324391
      assigned_by: UniProt
    - protein: UniProtKB:F4J3T8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.1.3.95
    - protein: UniProtKB:F4J3T8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:39019
    - protein: UniProtKB:F4JWB3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22324391
      assigned_by: UniProt
    - protein: UniProtKB:F4JWB3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.1.3.95
    - protein: UniProtKB:F4JWB3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:39019
  - go_id: GO:0032006
    label: regulation of TOR signaling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 107
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0529
    p_value: 9.29e-07
    q_value: 3.63e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JFA0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30098100
      assigned_by: TAIR
  - go_id: GO:0009932
    label: cell tip growth
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 10
    rate_ratio: 0.053
    p_value: 2.16e-06
    q_value: 8.02e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YSM5
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P22389|ensembl:ENSMUSP00000030384
    - protein: UniProtKB:P20800
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P22389|ensembl:ENSMUSP00000030384
    - protein: UniProtKB:P22389
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:24043815
      assigned_by: MGI
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0009932
  - go_id: GO:0004722
    label: protein serine/threonine phosphatase activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1164
      Archaea: 1
      Bacteria: 16
      Fungi: 73
      Plants: 329
    rate_ratio: 0.0532
    p_value: 4.37e-07
    q_value: 1.78e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4JAD1
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.1.3.16|EC:3.1.3.16
    - protein: UniProtKB:Q4JAD1
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000186161
  - go_id: GO:0005518
    label: collagen binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 342
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0533
    p_value: 4.36e-07
    q_value: 1.78e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q183R6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR008456
  - go_id: GO:0016422
    label: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 106
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0534
    p_value: 1.08e-06
    q_value: 4.18e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O65090
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:9596631
      assigned_by: TAIR
  - go_id: GO:0051050
    label: positive regulation of transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 106
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0534
    p_value: 1.08e-06
    q_value: 4.18e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94K05
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21868675
      assigned_by: UniProt
  - go_id: GO:0009381
    label: excinuclease ABC activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 21
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0535
    p_value: 3.4e-05
    q_value: 0.000107
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PJ54
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001162
  - go_id: GO:0045089
    label: positive regulation of innate immune response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 211
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0536
    p_value: 1.3e-12
    q_value: 9.19e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SCP5
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:33866633
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G53160
    - protein: UniProtKB:Q9SKB2
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:24259685
      assigned_by: PHI-base
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0045089
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0045089
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0045089
  - go_id: GO:0005882
    label: intermediate filament
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 377
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0543
    p_value: 5.76e-07
    q_value: 2.32e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q03898
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:11929974
      assigned_by: SGD
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005882
  - go_id: GO:0009967
    label: positive regulation of signal transduction
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 312
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0544
    p_value: 3.22e-18
    q_value: 3.34e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O24456
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027202
    - protein: UniProtKB:O24456
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25731164
      assigned_by: UniProt
    - protein: UniProtKB:Q9C4Z6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027202
    - protein: UniProtKB:Q9C4Z6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25731164
      assigned_by: UniProt
    - protein: UniProtKB:Q9LV28
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027202
    - protein: UniProtKB:Q9LV28
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25731164
      assigned_by: UniProt
  - go_id: GO:0045892
    label: negative regulation of DNA-templated transcription
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3986
      Archaea: 3
      Bacteria: 299
      Fungi: 43
      Plants: 323
    rate_ratio: 0.0545
    p_value: 4.24e-18
    q_value: 4.36e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4J6R0
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001248570
    - protein: UniProtKB:Q4JCK1
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002112389
    - protein: UniProtKB:Q9HIH7
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002112387
  - go_id: GO:0008509
    label: monoatomic anion transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 207
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0546
    p_value: 2.4e-12
    q_value: 1.66e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O49696
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:20154005
      assigned_by: TAIR
    - protein: UniProtKB:Q9LD83
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: DOI:10.1038/nature09487
      assigned_by: UniProt
      gene_review: genes/ARATH/SLAC1/SLAC1-ai-review.yaml
    - protein: UniProtKB:Q9LD83
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18305484
      assigned_by: UniProt
      gene_review: genes/ARATH/SLAC1/SLAC1-ai-review.yaml
  - go_id: GO:0006307
    label: DNA alkylation repair
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 80
      Archaea: 1
      Bacteria: 17
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0548
    p_value: 2.48e-08
    q_value: 1.17e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HXH4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002452908|PomBase:SPAPB24D3.04c|SGD:S000000944|UniProtKB:P04395|UniProtKB:P9WJW3
    - protein: UniProtKB:Q9SIE0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G22260|MGI:MGI:2141032|PANTHER:PTN001268735|UniProtKB:Q6NS38
    - protein: UniProtKB:Q9SIE0
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22532610
      assigned_by: GO_Central
    - protein: UniProtKB:Q9SVL1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002452908|PomBase:SPAPB24D3.04c|SGD:S000000944|UniProtKB:P04395|UniProtKB:P9WJW3
  - go_id: GO:0120242
    label: 2-iminobutanoate deaminase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0549
    p_value: 0.005
    q_value: 0.0104
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P52758
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:22094463
      assigned_by: UniProt
    - protein: UniProtKB:P52758
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:39975
    - protein: UniProtKB:P52758
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-9014641
      assigned_by: Reactome
    - protein: UniProtKB:P52760
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:39975
    - protein: UniProtKB:P52760
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P52758
    - protein: UniProtKB:P52760
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P52758
    - protein: UniProtKB:Q9V3W0
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P37552
  - go_id: GO:1900542
    label: regulation of purine nucleotide metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0549
    p_value: 0.005
    q_value: 0.0104
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XGG6
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2445077|PANTHER:PTN001255556
    - protein: UniProtKB:A0A8V0XGG6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8BZT9|ensembl:ENSMUSP00000059173
    - protein: UniProtKB:Q8BZT9
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2445077|PANTHER:PTN001255556
    - protein: UniProtKB:Q8BZT9
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:31978345
      assigned_by: UniProt
    - protein: UniProtKB:Q8IV20
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2445077|PANTHER:PTN001255556
    - protein: UniProtKB:Q8IV20
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8BZT9|ensembl:ENSMUSP00000059173
    - protein: UniProtKB:Q8IV20
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8BZT9
  - go_id: GO:0015517
    label: galactose:proton symporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0549
    p_value: 0.005
    q_value: 0.0104
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B0QZL3
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:708502
    - protein: UniProtKB:Q8BIV7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:708502
    - protein: UniProtKB:Q8BIV7
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8K4S3
    - protein: UniProtKB:Q9Y2W3
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8K4S3
  - go_id: GO:0015574
    label: trehalose transmembrane transporter activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 3
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0549
    p_value: 0.005
    q_value: 0.0104
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z8N1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:20035867
      assigned_by: UniProt
      gene_review: genes/DROME/Tret1/Tret1-ai-review.yaml
    - protein: UniProtKB:A1Z8N1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:34032568
      assigned_by: UniProt
      gene_review: genes/DROME/Tret1/Tret1-ai-review.yaml
    - protein: UniProtKB:Q8MLQ7
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:33551766
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VPX2
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:33551766
      assigned_by: FlyBase
  - go_id: GO:0006270
    label: DNA replication initiation
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 358
      Archaea: 1
      Bacteria: 41
      Fungi: 88
      Plants: 79
    rate_ratio: 0.055
    p_value: 2.12e-06
    q_value: 7.91e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9HJD1
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001315680
  - go_id: GO:0070899
    label: mitochondrial tRNA wobble uridine modification
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SHS2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086587
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070899
  - go_id: GO:0007079
    label: mitotic chromosome movement towards spindle pole
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 62
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4ICA0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000649974|PomBase:SPBC1685.15c|PomBase:SPBC2F12.13|SGD:S000003184
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007079
  - go_id: GO:0000096
    label: sulfur amino acid metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 4
      Fungi: 10
      Plants: 2
    rate_ratio: 0.0553
    p_value: 1.93e-05
    q_value: 6.23e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O49485
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30787133
      assigned_by: TAIR
    - protein: UniProtKB:O82796
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30787133
      assigned_by: TAIR
  - go_id: GO:0010636
    label: positive regulation of mitochondrial fusion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 71
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J5S1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25165398
      assigned_by: TAIR
  - go_id: GO:0004608
    label: phosphatidylethanolamine N-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SAH5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000345849
  - go_id: GO:0180022
    label: RQC-trigger complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 37
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SN77
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008344380|UniProtKB:Q15650
    - protein: UniProtKB:Q9SN77
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR009349
  - go_id: GO:0043515
    label: kinetochore binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 59
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JT58
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:34850467
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G35520
  - go_id: GO:0051792
    label: medium-chain fatty acid biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LNJ4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17496121
      assigned_by: TAIR
  - go_id: GO:0032982
    label: myosin filament
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 70
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R9M6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN005210253|RGD:62030|UniProtKB:P12883|UniProtKB:P35579|UniProtKB:P35580|UniProtKB:Q7Z406|WB:WBGene00002348|WB:WBGene00003515|WB:WBGene00006789|dictyBase:DDB_G0286355
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0032982
  - go_id: GO:2000234
    label: positive regulation of rRNA processing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 57
      Archaea: 0
      Bacteria: 1
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FR53
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21266656
      assigned_by: UniProt
  - go_id: GO:2000369
    label: regulation of clathrin-dependent endocytosis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 73
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SIS4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23658066
      assigned_by: TAIR
  - go_id: GO:0044843
    label: cell cycle G1/S phase transition
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96327
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:15689342
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0044843
  - go_id: GO:0010513
    label: positive regulation of phosphatidylinositol biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 16
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94C26
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23833195
      assigned_by: UniProt
  - go_id: GO:0061673
    label: mitotic spindle astral microtubule
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4ICA0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000649974|PomBase:SPBC1685.15c|PomBase:SPBC2F12.13|SGD:S000003184
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0061673
  - go_id: GO:0004338
    label: glucan exo-1,3-beta-glucosidase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 2
    rate_ratio: 0.0553
    p_value: 1.93e-05
    q_value: 6.23e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O49353
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:10092183
      assigned_by: TAIR
    - protein: UniProtKB:P33157
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:1392589
      assigned_by: TAIR
  - go_id: GO:0016587
    label: Isw1 complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SFV2
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:32396248
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G28420,AGI_LocusCode:AT5G44180
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0016587
  - go_id: GO:0070823
    label: HDA1 complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T4Y8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR021006
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070823
  - go_id: GO:0006216
    label: cytidine catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 1
    rate_ratio: 0.0553
    p_value: 0.00468
    q_value: 0.00973
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O65896
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27208239
      assigned_by: TAIR
  - go_id: GO:0006797
    label: polyphosphate metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 16
      Plants: 0
    rate_ratio: 0.0556
    p_value: 0.000111
    q_value: 0.000318
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZE52
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR022489
  - go_id: GO:0044409
    label: symbiont entry into host
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 16
      Plants: 0
    rate_ratio: 0.0556
    p_value: 0.000111
    q_value: 0.000318
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0CL08
      taxon: NCBITaxon:99287
      evidence: IMP
      reference: PMID:28704543
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0044409
  - go_id: GO:0042350
    label: GDP-L-fucose biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 101
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.056
    p_value: 2.34e-06
    q_value: 8.66e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I938
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0050577
  - go_id: GO:0003847
    label: 1-alkyl-2-acetylglycerophosphocholine esterase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 101
      Archaea: 0
      Bacteria: 1
      Fungi: 1
      Plants: 1
    rate_ratio: 0.056
    p_value: 2.34e-06
    q_value: 8.66e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QS42
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1351327|PANTHER:PTN000031087|PomBase:SPBC106.11c|RGD:631399|UniProtKB:P79106|UniProtKB:Q13093|UniProtKB:Q99487|WB:WBGene00003906|WB:WBGene00003907
    - protein: UniProtKB:D8QS42
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.1.1.47|EC:3.1.1.47
  - go_id: GO:0033044
    label: regulation of chromosome organization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 202
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 2
    rate_ratio: 0.056
    p_value: 5.16e-12
    q_value: 3.47e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FKS4
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:16166376
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G48190
    - protein: UniProtKB:Q9M3G7
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:17989233
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G16850
  - go_id: GO:0019894
    label: kinesin binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 364
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 5
    rate_ratio: 0.0562
    p_value: 1.04e-06
    q_value: 4.01e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P11709
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:35235370
      assigned_by: SGD
  - go_id: GO:0004536
    label: DNA nuclease activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 53
      Archaea: 1
      Bacteria: 11
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0564
    p_value: 1.26e-05
    q_value: 4.21e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R4M4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002131615|UniProtKB:P08038|UniProtKB:P25736
    - protein: UniProtKB:Q9LX74
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: EnsemblPlants
      with_from: UniProtKB:Q84T68|RAP2022-09-01:Os03t0854200-01
  - go_id: GO:0032263
    label: GMP salvage
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 45
      Archaea: 0
      Bacteria: 11
      Fungi: 5
      Plants: 2
    rate_ratio: 0.0564
    p_value: 1.26e-05
    q_value: 4.21e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T0J1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:96217|PANTHER:PTN000501530|UniProtKB:P00492|UniProtKB:P0A9M2
    - protein: UniProtKB:F4IA25
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:96217|PANTHER:PTN000501530|UniProtKB:P00492|UniProtKB:P0A9M2
  - go_id: GO:0046820
    label: aminodeoxychorismate synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 11
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0564
    p_value: 1.26e-05
    q_value: 4.21e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QZ33
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G28880|PANTHER:PTN002599721|SGD:S000005316|UniProtKB:Q6TAS3
    - protein: UniProtKB:D8QZ33
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.6.1.85|EC:2.6.1.85
    - protein: UniProtKB:D8QZ33
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: EnsemblPlants
      with_from: UniProtKB:Q8LPN3|araport11:AT2G28880.1
    - protein: UniProtKB:Q8LPN3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G28880|PANTHER:PTN002599721|SGD:S000005316|UniProtKB:Q6TAS3
    - protein: UniProtKB:Q8LPN3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:20851095
      assigned_by: TAIR
    - protein: UniProtKB:Q8LPN3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.6.1.85
    - protein: UniProtKB:Q8LPN3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:11672
    - protein: UniProtKB:Q8LPN3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084915
  - go_id: GO:0099503
    label: secretory vesicle
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 161
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 192
    rate_ratio: 0.0566
    p_value: 1.19e-16
    q_value: 1.11e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P33199
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:33634134
      assigned_by: SGD
    - protein: UniProtKB:P41697
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:30076201
      assigned_by: SGD
    - protein: UniProtKB:Q12500
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:42714338
      assigned_by: SGD
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0099503
  - go_id: GO:0008810
    label: cellulase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 4
      Fungi: 1
      Plants: 64
    rate_ratio: 0.0566
    p_value: 4.92e-06
    q_value: 1.73e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P42835
      taxon: NCBITaxon:559292
      evidence: TAS
      reference: PMID:11046133
      assigned_by: SGD
  - go_id: GO:0140934
    label: histone deubiquitinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 100
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0566
    p_value: 2.72e-06
    q_value: 9.99e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XIP2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:21690391
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0140934
  - go_id: GO:0045785
    label: positive regulation of cell adhesion
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 360
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0569
    p_value: 1.24e-06
    q_value: 4.75e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9HGP0
      taxon: NCBITaxon:284812
      evidence: IMP
      reference: PMID:22180499
      assigned_by: PomBase
  - go_id: GO:0070626
    label: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming)
      activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 30
      Archaea: 3
      Bacteria: 8
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QZE4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:23920
    - protein: UniProtKB:D8RWG5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:23920
    - protein: UniProtKB:F4I1L9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:23920
  - go_id: GO:0004644
    label: phosphoribosylglycinamide formyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 25
      Archaea: 3
      Bacteria: 10
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R2R3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000055290|SGD:S000002816|UniProtKB:P08179
    - protein: UniProtKB:D8R2R3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004607
    - protein: UniProtKB:D8R2R3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.2.2|EC:2.1.2.2
    - protein: UniProtKB:D8STB5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000055290|SGD:S000002816|UniProtKB:P08179
    - protein: UniProtKB:D8STB5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004607
    - protein: UniProtKB:D8STB5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.2.2|EC:2.1.2.2
    - protein: UniProtKB:P52422
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000055290|SGD:S000002816|UniProtKB:P08179
    - protein: UniProtKB:P52422
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004607
    - protein: UniProtKB:P52422
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.2.2
    - protein: UniProtKB:P52422
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:15053
  - go_id: GO:0004418
    label: hydroxymethylbilane synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 52
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QTP5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G08280|CGD:CAL0000176208|MGI:MGI:96112|PANTHER:PTN000168159|RGD:2801|SGD:S000002364|UniProtKB:P06983|UniProtKB:P08397
    - protein: UniProtKB:D8QTP5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000860|InterPro:IPR022417|InterPro:IPR022418|InterPro:IPR022419|InterPro:IPR036803
    - protein: UniProtKB:D8QTP5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.5.1.61|EC:2.5.1.61
    - protein: UniProtKB:D8QTP5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028611
    - protein: UniProtKB:D8T3U1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G08280|CGD:CAL0000176208|MGI:MGI:96112|PANTHER:PTN000168159|RGD:2801|SGD:S000002364|UniProtKB:P06983|UniProtKB:P08397
    - protein: UniProtKB:D8T3U1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000860|InterPro:IPR022417|InterPro:IPR022418|InterPro:IPR022419|InterPro:IPR036803
    - protein: UniProtKB:D8T3U1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.5.1.61|EC:2.5.1.61
    - protein: UniProtKB:D8T3U1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028611
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G08280|CGD:CAL0000176208|MGI:MGI:96112|PANTHER:PTN000168159|RGD:2801|SGD:S000002364|UniProtKB:P06983|UniProtKB:P08397
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8192681
      assigned_by: TAIR
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000860|InterPro:IPR022417|InterPro:IPR022418|InterPro:IPR022419|InterPro:IPR036803
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.5.1.61
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13185
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028611
    - protein: UniProtKB:Q43316
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23308205
      assigned_by: TAIR
  - go_id: GO:0004585
    label: ornithine carbamoyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 27
      Archaea: 3
      Bacteria: 9
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SUH0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000150424|PomBase:SPAC4G9.10|RGD:3236|SGD:S000003624|UniProtKB:P00480|UniProtKB:P04391|UniProtKB:P06960|UniProtKB:P08308|UniProtKB:P9WIT9|UniProtKB:Q9YHY9
    - protein: UniProtKB:D8SUH0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024904
    - protein: UniProtKB:D8SUH0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.3.3|EC:2.1.3.3
    - protein: UniProtKB:D8SUH0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033579
    - protein: UniProtKB:D8SZY7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000150424|PomBase:SPAC4G9.10|RGD:3236|SGD:S000003624|UniProtKB:P00480|UniProtKB:P04391|UniProtKB:P06960|UniProtKB:P08308|UniProtKB:P9WIT9|UniProtKB:Q9YHY9
    - protein: UniProtKB:D8SZY7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024904
    - protein: UniProtKB:D8SZY7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.3.3|EC:2.1.3.3
    - protein: UniProtKB:D8SZY7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033579
    - protein: UniProtKB:O50039
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000150424|PomBase:SPAC4G9.10|RGD:3236|SGD:S000003624|UniProtKB:P00480|UniProtKB:P04391|UniProtKB:P06960|UniProtKB:P08308|UniProtKB:P9WIT9|UniProtKB:Q9YHY9
    - protein: UniProtKB:O50039
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR024904
    - protein: UniProtKB:O50039
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.3.3
    - protein: UniProtKB:O50039
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:19513
    - protein: UniProtKB:O50039
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00033579
  - go_id: GO:0004056
    label: argininosuccinate lyase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 50
      Archaea: 3
      Bacteria: 5
      Fungi: 4
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RTQ6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000190527|PANTHER:PTN000154674|PomBase:SPBC1773.14|RGD:619974|SGD:S000001060|UniProtKB:P04424|UniProtKB:P11447|UniProtKB:P73257
    - protein: UniProtKB:D8RTQ6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR009049
    - protein: UniProtKB:D8RTQ6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.2.1|EC:4.3.2.1
    - protein: UniProtKB:D8T5F5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000190527|PANTHER:PTN000154674|PomBase:SPBC1773.14|RGD:619974|SGD:S000001060|UniProtKB:P04424|UniProtKB:P11447|UniProtKB:P73257
    - protein: UniProtKB:D8T5F5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR009049
    - protein: UniProtKB:D8T5F5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.2.1|EC:4.3.2.1
    - protein: UniProtKB:Q9LEU8
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000190527|PANTHER:PTN000154674|PomBase:SPBC1773.14|RGD:619974|SGD:S000001060|UniProtKB:P04424|UniProtKB:P11447|UniProtKB:P73257
    - protein: UniProtKB:Q9LEU8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR009049
    - protein: UniProtKB:Q9LEU8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.3.2.1
    - protein: UniProtKB:Q9LEU8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24020
  - go_id: GO:0004087
    label: carbamoyl-phosphate synthase (ammonia) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 27
      Archaea: 3
      Bacteria: 8
      Fungi: 6
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RF71
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:891996|PANTHER:PTN008517424|RGD:2395|SGD:S000003870|UniProtKB:P31327|UniProtKB:Q7SH52|ZFIN:ZDB-GENE-081105-17
    - protein: UniProtKB:D8RF71
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.4.16|EC:6.3.4.16
    - protein: UniProtKB:D8SDC5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:891996|PANTHER:PTN008517424|RGD:2395|SGD:S000003870|UniProtKB:P31327|UniProtKB:Q7SH52|ZFIN:ZDB-GENE-081105-17
    - protein: UniProtKB:D8SDC5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.4.16|EC:6.3.4.16
    - protein: UniProtKB:Q42601
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:891996|PANTHER:PTN008517424|RGD:2395|SGD:S000003870|UniProtKB:P31327|UniProtKB:Q7SH52|ZFIN:ZDB-GENE-081105-17
    - protein: UniProtKB:Q42601
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.4.16
    - protein: UniProtKB:Q42601
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:18029
    - protein: UniProtKB:Q42601
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P03965
  - go_id: GO:0004360
    label: L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 62
      Archaea: 3
      Bacteria: 13
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8STI3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000176261|FB:FBgn0039580|FB:FBgn0287209|PANTHER:PTN000101302|RGD:1549703|SGD:S000001587|UniProtKB:O94808|UniProtKB:P17169|UniProtKB:Q06210
    - protein: UniProtKB:D8STI3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.6.1.16|EC:2.6.1.16
    - protein: UniProtKB:D8T582
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000176261|FB:FBgn0039580|FB:FBgn0287209|PANTHER:PTN000101302|RGD:1549703|SGD:S000001587|UniProtKB:O94808|UniProtKB:P17169|UniProtKB:Q06210
    - protein: UniProtKB:D8T582
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.6.1.16|EC:2.6.1.16
    - protein: UniProtKB:Q9LIP9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000176261|FB:FBgn0039580|FB:FBgn0287209|PANTHER:PTN000101302|RGD:1549703|SGD:S000001587|UniProtKB:O94808|UniProtKB:P17169|UniProtKB:Q06210
    - protein: UniProtKB:Q9LIP9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005855
    - protein: UniProtKB:Q9LIP9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.6.1.16
    - protein: UniProtKB:Q9LIP9
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P82808
  - go_id: GO:0052856
    label: NAD(P)HX epimerase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 32
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R082
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2180167|PANTHER:PTN000325829|RGD:1304699|SGD:S000005144|UniProtKB:Q8NCW5
    - protein: UniProtKB:D8R082
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:5.1.99.6|EC:5.1.99.6
    - protein: UniProtKB:D8R082
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375952
    - protein: UniProtKB:D8R082
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:32215|RHEA:32227
    - protein: UniProtKB:D8SZQ0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2180167|PANTHER:PTN000325829|RGD:1304699|SGD:S000005144|UniProtKB:Q8NCW5
    - protein: UniProtKB:D8SZQ0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:5.1.99.6|EC:5.1.99.6
    - protein: UniProtKB:D8SZQ0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375952
    - protein: UniProtKB:D8SZQ0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:32215|RHEA:32227
    - protein: UniProtKB:Q9LTX3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:24599492
      assigned_by: TAIR
    - protein: UniProtKB:Q9LTX3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR021198
    - protein: UniProtKB:Q9LTX3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:5.1.99.6
    - protein: UniProtKB:Q9LTX3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375952
    - protein: UniProtKB:Q9LTX3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:32215|RHEA:32227
  - go_id: GO:0019240
    label: L-citrulline biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 25
      Archaea: 3
      Bacteria: 9
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SUH0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000150424|RGD:3236|UniProtKB:P00480|UniProtKB:P04391|UniProtKB:P06960
    - protein: UniProtKB:D8SZY7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000150424|RGD:3236|UniProtKB:P00480|UniProtKB:P04391|UniProtKB:P06960
    - protein: UniProtKB:O50039
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000150424|RGD:3236|UniProtKB:P00480|UniProtKB:P04391|UniProtKB:P06960
  - go_id: GO:0004019
    label: adenylosuccinate synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 104
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RGZ6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:87947|MGI:MGI:87948|PANTHER:PTN000217844|PomBase:SPAC144.03|RGD:1310508|RGD:1590342|SGD:S000005164|UniProtKB:P0A7D4|UniProtKB:P30520|UniProtKB:Q8N142|dictyBase:DDB_G0285429
    - protein: UniProtKB:D8RGZ6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001114
    - protein: UniProtKB:D8RGZ6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.4.4|EC:6.3.4.4
    - protein: UniProtKB:D8RGZ6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375791
    - protein: UniProtKB:D8RGZ6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:15753
    - protein: UniProtKB:D8S5K6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:87947|MGI:MGI:87948|PANTHER:PTN000217844|PomBase:SPAC144.03|RGD:1310508|RGD:1590342|SGD:S000005164|UniProtKB:P0A7D4|UniProtKB:P30520|UniProtKB:Q8N142|dictyBase:DDB_G0285429
    - protein: UniProtKB:D8S5K6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001114
    - protein: UniProtKB:D8S5K6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.4.4|EC:6.3.4.4
    - protein: UniProtKB:D8S5K6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375791
    - protein: UniProtKB:D8S5K6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:15753
    - protein: UniProtKB:Q96529
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:87947|MGI:MGI:87948|PANTHER:PTN000217844|PomBase:SPAC144.03|RGD:1310508|RGD:1590342|SGD:S000005164|UniProtKB:P0A7D4|UniProtKB:P30520|UniProtKB:Q8N142|dictyBase:DDB_G0285429
    - protein: UniProtKB:Q96529
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001114
    - protein: UniProtKB:Q96529
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.4.4
    - protein: UniProtKB:Q96529
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375791
    - protein: UniProtKB:Q96529
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:15753
  - go_id: GO:0003842
    label: L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 46
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RC17
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G62530|PANTHER:PTN000192427
    - protein: UniProtKB:D8T2W4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G62530|PANTHER:PTN000192427
    - protein: UniProtKB:Q8VZC3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G62530|PANTHER:PTN000192427
      gene_review: genes/ARATH/ALDH12A1/ALDH12A1-ai-review.yaml
    - protein: UniProtKB:Q8VZC3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.1.88
      gene_review: genes/ARATH/ALDH12A1/ALDH12A1-ai-review.yaml
    - protein: UniProtKB:Q8VZC3
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:11532180
      assigned_by: TAIR
      gene_review: genes/ARATH/ALDH12A1/ALDH12A1-ai-review.yaml
  - go_id: GO:0004070
    label: aspartate carbamoyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 17
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SVC7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002082
    - protein: UniProtKB:D8SVC7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.3.2|EC:2.1.3.2
    - protein: UniProtKB:D8T0T6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002082
    - protein: UniProtKB:D8T0T6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.3.2|EC:2.1.3.2
    - protein: UniProtKB:P49077
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002082
    - protein: UniProtKB:P49077
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.3.2
    - protein: UniProtKB:P49077
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:20013
    - protein: UniProtKB:P49077
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P0A786
  - go_id: GO:0004151
    label: dihydroorotase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 17
      Archaea: 3
      Bacteria: 9
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R5M0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000791117|SGD:S000004412|UniProtKB:C8VUF6|UniProtKB:P05020
    - protein: UniProtKB:D8R5M0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004721
    - protein: UniProtKB:D8R5M0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.2.3|EC:3.5.2.3
    - protein: UniProtKB:D8SFC7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000791117|SGD:S000004412|UniProtKB:C8VUF6|UniProtKB:P05020
    - protein: UniProtKB:D8SFC7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004721
    - protein: UniProtKB:D8SFC7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.2.3|EC:3.5.2.3
    - protein: UniProtKB:O04904
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000791117|SGD:S000004412|UniProtKB:C8VUF6|UniProtKB:P05020
    - protein: UniProtKB:O04904
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004721
    - protein: UniProtKB:O04904
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.2.3
    - protein: UniProtKB:O04904
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:24296
  - go_id: GO:0160107
    label: tRNA (adenine(58)-N1)-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 41
      Archaea: 3
      Bacteria: 0
      Fungi: 6
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QU12
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000253097|PomBase:SPAC9G1.12|UniProtKB:P9WFZ1|UniProtKB:Q96FX7|UniProtKB:Q9BVS5
    - protein: UniProtKB:D8QU12
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR014816
    - protein: UniProtKB:D8QU12
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.220|EC:2.1.1.220
    - protein: UniProtKB:D8QU12
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000415089
    - protein: UniProtKB:D8QU12
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:43152
    - protein: UniProtKB:D8QV77
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000253097|PomBase:SPAC9G1.12|UniProtKB:P9WFZ1|UniProtKB:Q96FX7|UniProtKB:Q9BVS5
    - protein: UniProtKB:D8QV77
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR014816
    - protein: UniProtKB:D8QV77
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.220|EC:2.1.1.220
    - protein: UniProtKB:D8QV77
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000415089
    - protein: UniProtKB:D8QV77
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:43152
    - protein: UniProtKB:F4K6U9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR014816
    - protein: UniProtKB:F4K6U9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.220|EC:2.1.1.220
    - protein: UniProtKB:F4K6U9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000415089
  - go_id: GO:0004639
    label: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 35
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R9C8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000196632|PANTHER:PTN000176702|PomBase:SPBC409.10|SGD:S000000070
    - protein: UniProtKB:D8R9C8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018236
    - protein: UniProtKB:D8R9C8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.2.6|EC:6.3.2.6
    - protein: UniProtKB:D8TAJ7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000196632|PANTHER:PTN000176702|PomBase:SPBC409.10|SGD:S000000070
    - protein: UniProtKB:D8TAJ7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018236
    - protein: UniProtKB:D8TAJ7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.2.6|EC:6.3.2.6
    - protein: UniProtKB:P38025
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000196632|PANTHER:PTN000176702|PomBase:SPBC409.10|SGD:S000000070
    - protein: UniProtKB:P38025
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018236
    - protein: UniProtKB:P38025
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.2.6
    - protein: UniProtKB:P38025
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22628
  - go_id: GO:0004152
    label: dihydroorotate dehydrogenase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 47
      Archaea: 3
      Bacteria: 8
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R3V8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G23300|CGD:CAL0000178448|FB:FBgn0000447|MGI:MGI:1928378|PANTHER:PTN000234184|PomBase:SPAC57A10.12c|RGD:68352|UniProtKB:G5EB61|UniProtKB:P0A7E1|UniProtKB:Q02127|UniProtKB:Q08210|UniProtKB:Q5E9W3
    - protein: UniProtKB:D8R3V8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005719
    - protein: UniProtKB:D8R3V8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: EnsemblPlants
      with_from: UniProtKB:P32746|araport11:AT5G23300.1
    - protein: UniProtKB:D8R3V8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00047233
    - protein: UniProtKB:D8RAG3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G23300|CGD:CAL0000178448|FB:FBgn0000447|MGI:MGI:1928378|PANTHER:PTN000234184|PomBase:SPAC57A10.12c|RGD:68352|UniProtKB:G5EB61|UniProtKB:P0A7E1|UniProtKB:Q02127|UniProtKB:Q08210|UniProtKB:Q5E9W3
    - protein: UniProtKB:D8RAG3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005719
    - protein: UniProtKB:D8RAG3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00047233
    - protein: UniProtKB:P32746
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G23300|CGD:CAL0000178448|FB:FBgn0000447|MGI:MGI:1928378|PANTHER:PTN000234184|PomBase:SPAC57A10.12c|RGD:68352|UniProtKB:G5EB61|UniProtKB:P0A7E1|UniProtKB:Q02127|UniProtKB:Q08210|UniProtKB:Q5E9W3
    - protein: UniProtKB:P32746
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:12372626
      assigned_by: TAIR
    - protein: UniProtKB:P32746
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005719
    - protein: UniProtKB:P32746
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00047233
  - go_id: GO:0017178
    label: diphthine-ammonia ligase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 36
      Archaea: 3
      Bacteria: 1
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T289
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000257633|SGD:S000004133|UniProtKB:Q7L8W6
    - protein: UniProtKB:D8T289
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.1.14|EC:6.3.1.14
    - protein: UniProtKB:D8T858
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000257633|SGD:S000004133|UniProtKB:Q7L8W6
    - protein: UniProtKB:D8T858
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.1.14|EC:6.3.1.14
    - protein: UniProtKB:F4J3Q1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000257633|SGD:S000004133|UniProtKB:Q7L8W6
    - protein: UniProtKB:F4J3Q1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:6.3.1.14|EC:6.3.1.14
  - go_id: GO:0003998
    label: acylphosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 30
      Archaea: 3
      Bacteria: 6
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RM90
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR020456
    - protein: UniProtKB:D8RM90
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.6.1.7|EC:3.6.1.7
    - protein: UniProtKB:D8RM90
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:14965
    - protein: UniProtKB:D8S2J6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR020456
    - protein: UniProtKB:D8S2J6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.6.1.7|EC:3.6.1.7
    - protein: UniProtKB:D8S2J6
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:14965
    - protein: UniProtKB:Q9LZF2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR020456
    - protein: UniProtKB:Q9LZF2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.6.1.7|EC:3.6.1.7
  - go_id: GO:0046040
    label: IMP metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 27
      Archaea: 3
      Bacteria: 6
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RGZ6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000217844|RGD:1310508|RGD:1590342
    - protein: UniProtKB:D8S5K6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000217844|RGD:1310508|RGD:1590342
    - protein: UniProtKB:Q96529
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000217844|RGD:1310508|RGD:1590342
  - go_id: GO:0004413
    label: homoserine kinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 7
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R3R1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000870
    - protein: UniProtKB:D8R3R1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.39|EC:2.7.1.39
    - protein: UniProtKB:D8SIF2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000870
    - protein: UniProtKB:D8SIF2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.39|EC:2.7.1.39
    - protein: UniProtKB:Q8L7R2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15703056
      assigned_by: TAIR
      gene_review: genes/ARATH/HSK/HSK-ai-review.yaml
    - protein: UniProtKB:Q8L7R2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000870
      gene_review: genes/ARATH/HSK/HSK-ai-review.yaml
    - protein: UniProtKB:Q8L7R2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.1.39
      gene_review: genes/ARATH/HSK/HSK-ai-review.yaml
    - protein: UniProtKB:Q8L7R2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13985
      gene_review: genes/ARATH/HSK/HSK-ai-review.yaml
  - go_id: GO:0004048
    label: anthranilate phosphoribosyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 8
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R2J8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005940
    - protein: UniProtKB:D8R2J8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.2.18|EC:2.4.2.18
    - protein: UniProtKB:D8ST47
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005940
    - protein: UniProtKB:D8ST47
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.2.18|EC:2.4.2.18
    - protein: UniProtKB:Q02166
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005940
    - protein: UniProtKB:Q02166
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.2.18
    - protein: UniProtKB:Q02166
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:11768
    - protein: UniProtKB:Q02166
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:9017401
      assigned_by: TAIR
  - go_id: GO:0003855
    label: 3-dehydroquinate dehydratase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 8
      Fungi: 4
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S7P3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001381|InterPro:IPR018508
    - protein: UniProtKB:D8S7P3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027694
    - protein: UniProtKB:D8T411
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001381|InterPro:IPR018508
    - protein: UniProtKB:D8T411
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027694
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:16784230
      assigned_by: UniProt
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001381
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.2.1.10
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:21096
  - go_id: GO:0004764
    label: shikimate 3-dehydrogenase (NADP+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 11
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S7P3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G06350|PANTHER:PTN000472519|UniProtKB:I6Y120|UniProtKB:O67049|UniProtKB:P0A6D5|UniProtKB:P15770|UniProtKB:P25415|UniProtKB:P44774
    - protein: UniProtKB:D8S7P3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011342|InterPro:IPR013708|InterPro:IPR022893
    - protein: UniProtKB:D8S7P3
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.25|EC:1.1.1.25
    - protein: UniProtKB:D8T411
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G06350|PANTHER:PTN000472519|UniProtKB:I6Y120|UniProtKB:O67049|UniProtKB:P0A6D5|UniProtKB:P15770|UniProtKB:P25415|UniProtKB:P44774
    - protein: UniProtKB:D8T411
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011342|InterPro:IPR013708|InterPro:IPR022893
    - protein: UniProtKB:D8T411
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.25|EC:1.1.1.25
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G06350|PANTHER:PTN000472519|UniProtKB:I6Y120|UniProtKB:O67049|UniProtKB:P0A6D5|UniProtKB:P15770|UniProtKB:P25415|UniProtKB:P44774
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16784230
      assigned_by: TAIR
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR011342|InterPro:IPR013708|InterPro:IPR022893
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.25
    - protein: UniProtKB:Q9SQT8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:17737
  - go_id: GO:0008614
    label: pyridoxine metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QSM3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000774355|SGD:S000001834|SGD:S000004701
    - protein: UniProtKB:D8R1U4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000774355|SGD:S000001834|SGD:S000004701
    - protein: UniProtKB:Q8LAD0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000774355|SGD:S000001834|SGD:S000004701
  - go_id: GO:1903600
    label: glutaminase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 7
      Plants: 3
    rate_ratio: 0.0571
    p_value: 0.00557
    q_value: 0.0113
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QSM3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000774355|SGD:S000004701
    - protein: UniProtKB:D8R1U4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000774355|SGD:S000004701
    - protein: UniProtKB:Q8LAD0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000774355|SGD:S000004701
  - go_id: GO:0045429
    label: positive regulation of nitric oxide biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 198
      Archaea: 0
      Bacteria: 1
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0571
    p_value: 9.52e-12
    q_value: 6.25e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QPQ2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1916469|PANTHER:PTN000978164|RGD:70968|UniProtKB:P56965|UniProtKB:Q3SX44
    - protein: UniProtKB:D8SKS3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1916469|PANTHER:PTN000978164|RGD:70968|UniProtKB:P56965|UniProtKB:Q3SX44
  - go_id: GO:0009968
    label: negative regulation of signal transduction
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 316
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 6
    rate_ratio: 0.0577
    p_value: 1.62e-06
    q_value: 6.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P33226
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:10411745
      assigned_by: EcoCyc
  - go_id: GO:0008277
    label: regulation of G protein-coupled receptor signaling pathway
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 354
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0578
    p_value: 1.63e-06
    q_value: 6.12e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PNF8
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:16400182
      assigned_by: CGD
  - go_id: GO:0015232
    label: heme transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 87
      Archaea: 0
      Bacteria: 16
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0582
    p_value: 8.93e-08
    q_value: 4.01e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IL76
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003557
    - protein: UniProtKB:F4IL90
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003567|InterPro:IPR003569
    - protein: UniProtKB:F4IMA2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003557
  - go_id: GO:0008990
    label: rRNA (guanine-N2-)-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 16
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0582
    p_value: 8.93e-08
    q_value: 4.01e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1I9LP45
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34015128
      assigned_by: TAIR
    - protein: UniProtKB:A0A1I9LP46
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34015128
      assigned_by: TAIR
    - protein: UniProtKB:Q9LSI8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34015128
      assigned_by: TAIR
  - go_id: GO:0005539
    label: glycosaminoglycan binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 97
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0583
    p_value: 4.31e-06
    q_value: 1.53e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZVA4
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:30156702
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G34850
  - go_id: GO:0045176
    label: apical protein localization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 97
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0583
    p_value: 4.31e-06
    q_value: 1.53e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8H1D3
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:16107478
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G34650
  - go_id: GO:0005547
    label: phosphatidylinositol-3,4,5-trisphosphate binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 291
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 3
    rate_ratio: 0.0583
    p_value: 8.02e-17
    q_value: 7.6e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VWF1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28584166
      assigned_by: UniProt
    - protein: UniProtKB:Q96262
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18397324
      assigned_by: TAIR
    - protein: UniProtKB:Q96262
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18397324
      assigned_by: UniProt
    - protein: UniProtKB:Q9FG74
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27251533
      assigned_by: UniProt
      gene_review: genes/ARATH/D6PK/D6PK-ai-review.yaml
  - go_id: GO:0106435
    label: carboxylesterase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 221
      Archaea: 0
      Bacteria: 14
      Fungi: 1
      Plants: 62
    rate_ratio: 0.0584
    p_value: 7.78e-06
    q_value: 2.67e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P28321
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:50144|RHEA:50148|RHEA:50136
  - go_id: GO:0008886
    label: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 1
      Fungi: 0
      Plants: 55
    rate_ratio: 0.0586
    p_value: 9.8e-06
    q_value: 3.31e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q189C4
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.1.9|EC:1.2.1.9
  - go_id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 1044
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0588
    p_value: 9.71e-18
    q_value: 9.76e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PTJ4
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0031006|PANTHER:PTN000329282|RGD:1307224|UniProtKB:Q6R327|dictyBase:DDB_G0277399
    - protein: UniProtKB:P40061
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0031006|PANTHER:PTN000329282|RGD:1307224|UniProtKB:Q6R327|dictyBase:DDB_G0277399
    - protein: UniProtKB:Q09743
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0031006|PANTHER:PTN000329282|RGD:1307224|UniProtKB:Q6R327|dictyBase:DDB_G0277399
  - go_id: GO:0032922
    label: circadian regulation of gene expression
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 348
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 28
    rate_ratio: 0.0588
    p_value: 2.13e-06
    q_value: 7.92e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P05066
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0025680|MGI:MGI:1270841|MGI:MGI:1270859|PANTHER:PTN002479144
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0032922
  - go_id: GO:0001222
    label: transcription corepressor binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 348
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 13
    rate_ratio: 0.0588
    p_value: 2.13e-06
    q_value: 7.92e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39521
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:15620355
      assigned_by: SGD
      with_from: SGD:S000002631
  - go_id: GO:0007276
    label: gamete generation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 288
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0589
    p_value: 1.27e-16
    q_value: 1.19e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IH25
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26940494
      assigned_by: TAIR
    - protein: UniProtKB:Q38914
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:8742706
      assigned_by: TIGR
    - protein: UniProtKB:Q9ZRT1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18007598
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0007276
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0007276
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0007276
  - go_id: GO:0048571
    label: long-day photoperiodism
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 6
    rate_ratio: 0.0589
    p_value: 0.000489
    q_value: 0.00125
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O00253
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:F1MAG1|ensembl:ENSRNOP00000056384
    - protein: UniProtKB:P56473
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:F1MAG1|ensembl:ENSRNOP00000056384
  - go_id: GO:0018874
    label: benzoate metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0589
    p_value: 0.0241
    q_value: 0.0423
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q08AH1
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:11470804
      assigned_by: UniProt
  - go_id: GO:0002220
    label: innate immune response activating cell surface receptor signaling pathway
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0589
    p_value: 0.0241
    q_value: 0.0423
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8N149
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:27572839
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0002220
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0002220
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0002220
  - go_id: GO:0016122
    label: xanthophyll metabolic process
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0589
    p_value: 0.0241
    q_value: 0.0423
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q99NF1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25701869
      assigned_by: MGI
      with_from: MGI:MGI:4840382
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0016122
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0016122
  - go_id: GO:0015743
    label: malate transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0589
    p_value: 0.0241
    q_value: 0.0423
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9QZD8
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:621430
  - go_id: GO:1990359
    label: stress response to zinc ion
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 1
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0589
    p_value: 0.0241
    q_value: 0.0423
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O17003
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:25330323
      assigned_by: WB
      with_from: WB:WBGene00000912
    - protein: UniProtKB:O17003
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:25330323
      assigned_by: WB
      with_from: WB:WBGene00009813
    - protein: UniProtKB:O17003
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:25330323
      assigned_by: WB
  - go_id: GO:0015190
    label: L-leucine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 79
      Archaea: 0
      Bacteria: 19
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0591
    p_value: 0.000111
    q_value: 0.000319
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O59831
      taxon: NCBITaxon:284812
      evidence: IMP
      reference: PMID:22992726
      assigned_by: PomBase
  - go_id: GO:0016855
    label: racemase and epimerase activity, acting on amino acids and derivatives
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 19
      Fungi: 1
      Plants: 7
    rate_ratio: 0.0591
    p_value: 0.000111
    q_value: 0.000319
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09921
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001920
  - go_id: GO:0007097
    label: nuclear migration
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 211
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 3
    rate_ratio: 0.0592
    p_value: 3.43e-07
    q_value: 1.41e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O23702
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30404821
      assigned_by: TAIR
    - protein: UniProtKB:Q0WPU1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23973298
      assigned_by: UniProt
    - protein: UniProtKB:Q5XVI1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24891605
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007097
  - go_id: GO:0008494
    label: translation activator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 55
      Archaea: 0
      Bacteria: 1
      Fungi: 14
      Plants: 3
    rate_ratio: 0.0592
    p_value: 3.43e-07
    q_value: 1.41e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QN31
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G46610|PANTHER:PTN005403777
    - protein: UniProtKB:D8R709
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G46610|PANTHER:PTN005403777
    - protein: UniProtKB:Q9SNB7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G46610|PANTHER:PTN005403777
    - protein: UniProtKB:Q9SNB7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30844105
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0008494
  - go_id: GO:0016242
    label: negative regulation of macroautophagy
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 67
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 3
    rate_ratio: 0.0592
    p_value: 3.43e-07
    q_value: 1.41e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RPQ3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0021796|MGI:MGI:1928394|PANTHER:PTN000124327|PomBase:SPBC216.07c|UniProtKB:P42345
    - protein: UniProtKB:D8TFM6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0021796|MGI:MGI:1928394|PANTHER:PTN000124327|PomBase:SPBC216.07c|UniProtKB:P42345
    - protein: UniProtKB:Q9FR53
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0021796|MGI:MGI:1928394|PANTHER:PTN000124327|PomBase:SPBC216.07c|UniProtKB:P42345
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0016242
  - go_id: GO:1902275
    label: regulation of chromatin organization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 59
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 3
    rate_ratio: 0.0592
    p_value: 3.43e-07
    q_value: 1.41e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LGE3
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:35026437
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G18960
    - protein: UniProtKB:Q9FMT4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26457678
      assigned_by: UniProt
    - protein: UniProtKB:Q9XIP2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27999174
      assigned_by: UniProt
  - go_id: GO:0140567
    label: membrane protein dislocase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 24
      Archaea: 0
      Bacteria: 0
      Fungi: 14
      Plants: 3
    rate_ratio: 0.0592
    p_value: 3.43e-07
    q_value: 1.41e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T896
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000643319|SGD:S000000757|UniProtKB:Q9HD20
    - protein: UniProtKB:D8TBK6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000643319|SGD:S000000757|UniProtKB:Q9HD20
    - protein: UniProtKB:Q9LT02
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000643319|SGD:S000000757|UniProtKB:Q9HD20
  - go_id: GO:0120293
    label: dynein axonemal particle
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 95
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0595
    p_value: 5.86e-06
    q_value: 2.04e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RR31
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0542
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0120293
  - go_id: GO:0033214
    label: siderophore-iron import into cell
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 91
      Fungi: 15
      Plants: 21
    rate_ratio: 0.0597
    p_value: 6.41e-06
    q_value: 2.23e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LY11
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001253134
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0033214
  - go_id: GO:0018105
    label: peptidyl-serine phosphorylation
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 305
      Archaea: 0
      Bacteria: 1
      Fungi: 8
      Plants: 6
    rate_ratio: 0.0597
    p_value: 2.83e-06
    q_value: 1.03e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P11071
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:3112144
      assigned_by: EcoCyc
  - go_id: GO:0046777
    label: protein autophosphorylation
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 637
      Archaea: 0
      Bacteria: 28
      Fungi: 2
      Plants: 120
    rate_ratio: 0.0603
    p_value: 1.42e-10
    q_value: 8.4e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15442
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:10983975
      assigned_by: UniProt
      gene_review: genes/yeast/GCN2/GCN2-ai-review.yaml
    - protein: UniProtKB:P15442
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:2188100
      assigned_by: UniProt
      gene_review: genes/yeast/GCN2/GCN2-ai-review.yaml
    - protein: UniProtKB:P38070
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:26582391
      assigned_by: SGD
    - protein: UniProtKB:P38070
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:26582391
      assigned_by: SGD
  - go_id: GO:0031667
    label: response to nutrient levels
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 302
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 6
    rate_ratio: 0.0603
    p_value: 3.29e-06
    q_value: 1.19e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AD14
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:28469239
      assigned_by: EcoCyc
  - go_id: GO:0005249
    label: voltage-gated potassium channel activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 673
      Archaea: 0
      Bacteria: 4
      Fungi: 2
      Plants: 32
    rate_ratio: 0.0608
    p_value: 1.2e-11
    q_value: 7.81e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PL65
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: EnsemblFungi
      with_from: UniProtKB:P40310|sgd:YJL093C
    - protein: UniProtKB:P40310
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:16133265
      assigned_by: SGD
  - go_id: GO:0033179
    label: proton-transporting V-type ATPase, V0 domain
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 178
      Archaea: 6
      Bacteria: 2
      Fungi: 20
      Plants: 31
    rate_ratio: 0.0613
    p_value: 0.000593
    q_value: 0.00148
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q184E8
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002490
    - protein: UniProtKB:Q184E9
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000245
  - go_id: GO:0003689
    label: DNA clamp loader activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 94
      Archaea: 6
      Bacteria: 2
      Fungi: 22
      Plants: 21
    rate_ratio: 0.0613
    p_value: 0.000593
    q_value: 0.00148
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P28630
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:9927437
      assigned_by: EcoCyc
      gene_review: genes/ECOLI/holA/holA-ai-review.yaml
    - protein: UniProtKB:P28631
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:9927437
      assigned_by: EcoCyc
      gene_review: genes/ECOLI/holB/holB-ai-review.yaml
  - go_id: GO:0015936
    label: coenzyme A metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 35
      Archaea: 3
      Bacteria: 1
      Fungi: 4
      Plants: 4
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A951
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:8077207
      assigned_by: ComplexPortal
  - go_id: GO:0031118
    label: rRNA pseudouridine synthesis
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 41
      Archaea: 3
      Bacteria: 1
      Fungi: 9
      Plants: 8
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AA37
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:10383384
      assigned_by: EcoliWiki
  - go_id: GO:0004421
    label: hydroxymethylglutaryl-CoA synthase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 25
      Archaea: 3
      Bacteria: 1
      Fungi: 3
      Plants: 5
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P40830
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:101939|MGI:MGI:107592|PANTHER:PTN000222418|PomBase:SPAC4F8.14c|RGD:2804|RGD:70970|SGD:S000004595|UniProtKB:P23228|UniProtKB:P54868|UniProtKB:Q4P3F1
    - protein: UniProtKB:P40830
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR013746
  - go_id: GO:0030880
    label: RNA polymerase complex
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 33
      Archaea: 3
      Bacteria: 1
      Fungi: 6
      Plants: 12
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A800
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:2152188
      assigned_by: EcoliWiki
  - go_id: GO:0004449
    label: isocitrate dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 56
      Archaea: 3
      Bacteria: 1
      Fungi: 6
      Plants: 10
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18A33
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.41|EC:1.1.1.41
    - protein: UniProtKB:Q18A33
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001723057
  - go_id: GO:0004013
    label: adenosylhomocysteinase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 20
      Archaea: 3
      Bacteria: 1
      Fungi: 3
      Plants: 6
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q02TY0
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.13.2.1
    - protein: UniProtKB:Q02TY0
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000101657
    - protein: UniProtKB:Q02TY0
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:21708
    - protein: UniProtKB:Q02TY0
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002361476
  - go_id: GO:0043891
    label: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating, [NAD(P)+] ) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34425
      taxon: NCBITaxon:224308
      evidence: IDA
      reference: PMID:10799476
      assigned_by: UniProt
    - protein: UniProtKB:O34425
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.1.59
  - go_id: GO:0047100
    label: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 0
      Plants: 9
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34425
      taxon: NCBITaxon:224308
      evidence: EXP
      reference: PMID:10799476
      assigned_by: UniProt
    - protein: UniProtKB:O34425
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:10296
  - go_id: GO:0016843
    label: amine-lyase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 5
      Plants: 4
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P37527
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000782634|SGD:S000001835|SGD:S000004702|UniProtKB:P9WII9
  - go_id: GO:0050492
    label: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P94527
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR023003
      gene_review: genes/BACSU/egsA/egsA-ai-review.yaml
    - protein: UniProtKB:P94527
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.261
      gene_review: genes/BACSU/egsA/egsA-ai-review.yaml
    - protein: UniProtKB:P94527
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000103182
      gene_review: genes/BACSU/egsA/egsA-ai-review.yaml
  - go_id: GO:0106357
    label: glycerol-1-phosphate dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P94527
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:21412
      gene_review: genes/BACSU/egsA/egsA-ai-review.yaml
  - go_id: GO:0106358
    label: glycerol-1-phosphate dehydrogenase (NADP+) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P94527
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:21416
      gene_review: genes/BACSU/egsA/egsA-ai-review.yaml
  - go_id: GO:0043776
    label: cobalt-precorrin-6B C5-methyltransferase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 3
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0613
    p_value: 0.0265
    q_value: 0.0459
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q05632
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:36067
  - go_id: GO:2000232
    label: regulation of rRNA processing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 15
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 2
    rate_ratio: 0.0614
    p_value: 7.45e-05
    q_value: 0.00022
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JHU0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26139346
      assigned_by: TAIR
    - protein: UniProtKB:Q9LYK7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23909681
      assigned_by: TAIR
  - go_id: GO:0005496
    label: steroid binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 184
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0615
    p_value: 8.07e-11
    q_value: 4.9e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22476
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:21666665
      assigned_by: TAIR
      gene_review: genes/ARATH/BRI1/BRI1-ai-review.yaml
    - protein: UniProtKB:Q9XFM6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15608331
      assigned_by: TAIR
  - go_id: GO:1901363
    label: heterocyclic compound binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 184
      Archaea: 0
      Bacteria: 2
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0615
    p_value: 8.07e-11
    q_value: 4.9e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JXM5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027813
    - protein: UniProtKB:Q9FHN8
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027813
  - go_id: GO:0046655
    label: folic acid metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 92
      Archaea: 0
      Bacteria: 5
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0615
    p_value: 9.27e-06
    q_value: 3.14e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SPK5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00091997
  - go_id: GO:0007288
    label: sperm axoneme assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 183
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0618
    p_value: 9.4e-11
    q_value: 5.67e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8STG0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1277238|MGI:MGI:1289258|PANTHER:PTN008557012|UniProtKB:Q8NDM7|UniProtKB:Q96MT7
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0007288
    - protein: UniProtKB:D8T5A3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1277238|MGI:MGI:1289258|PANTHER:PTN008557012|UniProtKB:Q8NDM7|UniProtKB:Q96MT7
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0007288
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0007288
  - go_id: GO:0009791
    label: post-embryonic development
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 516
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 117
    rate_ratio: 0.0619
    p_value: 2.81e-10
    q_value: 1.63e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PNG6
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029007
    - protein: UniProtKB:Q59T43
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029007
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0009791
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0009791
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0009791
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0009791
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0009791
  - go_id: GO:0042177
    label: negative regulation of protein catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 274
      Archaea: 0
      Bacteria: 3
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0619
    p_value: 1.07e-15
    q_value: 9.34e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C800
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G12560|PANTHER:PTN008639574
    - protein: UniProtKB:Q9LZQ2
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G12560|PANTHER:PTN008639574
    - protein: UniProtKB:Q9SU30
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G12560|PANTHER:PTN008639574
    - protein: UniProtKB:Q9SU30
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21967323
      assigned_by: TAIR
  - go_id: GO:0015439
    label: ABC-type heme transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 5
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0621
    p_value: 0.00718
    q_value: 0.0142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C8T1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:7.6.2.5
    - protein: UniProtKB:Q9C8T1
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:19261
  - go_id: GO:0097681
    label: double-strand break repair via alternative nonhomologous end joining
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 58
      Archaea: 0
      Bacteria: 5
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0621
    p_value: 0.00718
    q_value: 0.0142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T5V4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1914053|PANTHER:PTN000340766
  - go_id: GO:0034618
    label: arginine binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 5
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0621
    p_value: 0.00718
    q_value: 0.0142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SCL7
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17913711
      assigned_by: UniProt
      gene_review: genes/ARATH/NAGK/NAGK-ai-review.yaml
  - go_id: GO:0015173
    label: aromatic amino acid transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 16
      Archaea: 0
      Bacteria: 10
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0621
    p_value: 4.52e-05
    q_value: 0.000139
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FKY3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27925655
      assigned_by: UniProt
    - protein: UniProtKB:Q9SF09
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:11299361
      assigned_by: TAIR
  - go_id: GO:0140431
    label: DNA-(abasic site) binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 11
      Archaea: 0
      Bacteria: 5
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0621
    p_value: 0.00718
    q_value: 0.0142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T5V4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000340766|UniProtKB:Q6IND6|UniProtKB:Q96FZ2
  - go_id: GO:0004123
    label: cystathionine gamma-lyase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 5
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0621
    p_value: 0.00718
    q_value: 0.0142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4K5T2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:14005
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0004123
  - go_id: GO:0008782
    label: adenosylhomocysteine nucleosidase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 5
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0621
    p_value: 0.00718
    q_value: 0.0142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7XA67
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:18342331
      assigned_by: UniProt
    - protein: UniProtKB:Q7XA67
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:19249293
      assigned_by: UniProt
    - protein: UniProtKB:Q7XA67
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.2.2.9
    - protein: UniProtKB:Q7XA67
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:17805
  - go_id: GO:0019808
    label: polyamine binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 15
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0621
    p_value: 3.19e-07
    q_value: 1.32e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T634
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001188
    - protein: UniProtKB:D8T7W8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001188
    - protein: UniProtKB:F4I9D4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001188
  - go_id: GO:0045814
    label: negative regulation of gene expression, epigenetic
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 293
      Archaea: 0
      Bacteria: 1
      Fungi: 8
      Plants: 51
    rate_ratio: 0.0622
    p_value: 5.17e-06
    q_value: 1.81e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A1S2
      taxon: NCBITaxon:99287
      evidence: IDA
      reference: PMID:16933988
      assigned_by: UniProt
  - go_id: GO:0034599
    label: cellular response to oxidative stress
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 663
      Archaea: 3
      Bacteria: 53
      Fungi: 230
      Plants: 133
    rate_ratio: 0.0631
    p_value: 3.82e-15
    q_value: 3.24e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4J6R7
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000074170
    - protein: UniProtKB:Q4JCJ2
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000841233
    - protein: UniProtKB:Q9HL73
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000074138
  - go_id: GO:0043622
    label: cortical microtubule organization
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 51
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 57
    rate_ratio: 0.0635
    p_value: 2.44e-05
    q_value: 7.77e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9P6S5
      taxon: NCBITaxon:284812
      evidence: IGI
      reference: PMID:20624975
      assigned_by: PomBase
      with_from: PomBase:SPAC18G6.15
  - go_id: GO:0018685
    label: alkane 1-monooxygenase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 24
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 57
    rate_ratio: 0.0635
    p_value: 2.44e-05
    q_value: 7.77e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q59K96
      taxon: NCBITaxon:237561
      evidence: IDA
      reference: PMID:17400174
      assigned_by: CGD
  - go_id: GO:0005432
    label: calcium:sodium antiporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 89
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0635
    p_value: 1.46e-05
    q_value: 4.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L636
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23148213
      assigned_by: TAIR
  - go_id: GO:1902004
    label: positive regulation of amyloid-beta formation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 89
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0635
    p_value: 1.46e-05
    q_value: 4.84e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZQI2
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P42574
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:1902004
  - go_id: GO:0030705
    label: cytoskeleton-dependent intracellular transport
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 216
      Archaea: 0
      Bacteria: 1
      Fungi: 14
      Plants: 36
    rate_ratio: 0.0636
    p_value: 0.000444
    q_value: 0.00115
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKN9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000436624
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030705
  - go_id: GO:0015189
    label: L-lysine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 44
      Archaea: 0
      Bacteria: 1
      Fungi: 14
      Plants: 16
    rate_ratio: 0.0636
    p_value: 0.000444
    q_value: 0.00115
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P25737
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:1315732
      assigned_by: EcoCyc
  - go_id: GO:0031990
    label: mRNA export from nucleus in response to heat stress
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 0
      Fungi: 13
      Plants: 3
    rate_ratio: 0.0638
    p_value: 1.31e-06
    q_value: 4.98e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SF75
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000479965|SGD:S000001540
    - protein: UniProtKB:D8SRT7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000479965|SGD:S000001540
    - protein: UniProtKB:Q9C811
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000479965|SGD:S000001540
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031990
  - go_id: GO:0016849
    label: phosphorus-oxygen lyase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 284
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 0
    rate_ratio: 0.0642
    p_value: 8.12e-06
    q_value: 2.77e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZCE6
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027001
  - go_id: GO:0015012
    label: heparan sulfate proteoglycan biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 264
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0643
    p_value: 4.89e-15
    q_value: 4.1e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RMB9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0038755|MGI:MGI:1354958|MGI:MGI:1354959|MGI:MGI:1354960|PANTHER:PTN000301790
    - protein: UniProtKB:D8SLF0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0038755|MGI:MGI:1354958|MGI:MGI:1354959|MGI:MGI:1354960|PANTHER:PTN000301790
    - protein: UniProtKB:Q3EDG5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0038755|MGI:MGI:1354958|MGI:MGI:1354959|MGI:MGI:1354960|PANTHER:PTN000301790
  - go_id: GO:0040014
    label: regulation of multicellular organism growth
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 176
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0643
    p_value: 2.73e-10
    q_value: 1.58e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P31265
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20736351
      assigned_by: TAIR
    - protein: UniProtKB:Q8RVL2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18952779
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0040014
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0040014
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0040014
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0040014
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0040014
  - go_id: GO:0010888
    label: negative regulation of lipid storage
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 88
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0643
    p_value: 1.71e-05
    q_value: 5.57e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O81270
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:16961733
      assigned_by: UniProt
  - go_id: GO:0039694
    label: viral RNA genome replication
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 88
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0643
    p_value: 1.71e-05
    q_value: 5.57e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LUW6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27456972
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0039694
  - go_id: GO:0051592
    label: response to calcium ion
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 317
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 23
    rate_ratio: 0.0646
    p_value: 8.56e-06
    q_value: 2.91e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PP58
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:16113294
      assigned_by: CGD
  - go_id: GO:0097708
    label: intracellular vesicle
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 174
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.065
    p_value: 3.69e-10
    q_value: 2.12e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8S8K8
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G25625|PANTHER:PTN002202256
    - protein: UniProtKB:Q8S8K8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25538186
      assigned_by: TAIR
    - protein: UniProtKB:Q9SX20
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27139299
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0097708
  - go_id: GO:0032794
    label: GTPase activating protein binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 87
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 1
    rate_ratio: 0.065
    p_value: 1.99e-05
    q_value: 6.4e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P92978
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:19108776
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G24580
  - go_id: GO:0043124
    label: negative regulation of canonical NF-kappaB signal transduction
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 627
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0653
    p_value: 9.42e-11
    q_value: 5.68e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P36134
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR038753
    - protein: UniProtKB:Q59MV2
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR038753
  - go_id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 3540
      Archaea: 3
      Bacteria: 0
      Fungi: 219
      Plants: 637
    rate_ratio: 0.0663
    p_value: 2.62e-14
    q_value: 2.07e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P25156
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000426
    - protein: UniProtKB:Q4JB24
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000426
    - protein: UniProtKB:Q6M0L9
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000426
  - go_id: GO:0071333
    label: cellular response to glucose stimulus
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 274
      Archaea: 2
      Bacteria: 1
      Fungi: 11
      Plants: 16
    rate_ratio: 0.0665
    p_value: 1.34e-05
    q_value: 4.46e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P30300
      taxon: NCBITaxon:224308
      evidence: IDA
      reference: PMID:9595668
      assigned_by: UniProt
    - protein: UniProtKB:P30300
      taxon: NCBITaxon:224308
      evidence: IMP
      reference: PMID:8825777
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0071333
  - go_id: GO:0051290
    label: protein heterotetramerization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 85
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0665
    p_value: 2.69e-05
    q_value: 8.54e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O65282
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:23783410
      assigned_by: UniProt
      with_from: UniProtKB:P29197
  - go_id: GO:0043394
    label: proteoglycan binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 84
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0673
    p_value: 3.13e-05
    q_value: 9.86e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O81865
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:20442276
      assigned_by: TAIR
  - go_id: GO:0070509
    label: calcium ion import
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 167
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0677
    p_value: 1.07e-09
    q_value: 5.86e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O65718
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:27999084
      assigned_by: TAIR
    - protein: UniProtKB:Q9LVR5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:31182842
      assigned_by: TAIR
  - go_id: GO:0010867
    label: positive regulation of triglyceride biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 83
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0681
    p_value: 3.65e-05
    q_value: 0.000114
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FLT5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23269834
      assigned_by: TAIR
  - go_id: GO:0048311
    label: mitochondrion distribution
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 83
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0681
    p_value: 3.65e-05
    q_value: 0.000114
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6NNL9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23370715
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0048311
  - go_id: GO:0042554
    label: superoxide anion generation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 83
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0681
    p_value: 3.65e-05
    q_value: 0.000114
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GUQ8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15941399
      assigned_by: TAIR
  - go_id: GO:0042273
    label: ribosomal large subunit biogenesis
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 325
      Archaea: 2
      Bacteria: 0
      Fungi: 142
      Plants: 69
    rate_ratio: 0.0681
    p_value: 1.68e-09
    q_value: 9.04e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4JAJ9
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000874722
    - protein: UniProtKB:Q6LZK2
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000874726
  - go_id: GO:0030041
    label: actin filament polymerization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 193
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 20
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZE15
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002904484
  - go_id: GO:0046512
    label: sphingosine biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 142
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 19
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z704
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002290561
  - go_id: GO:0005537
    label: D-mannose binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 125
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 0
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08191
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:1971261
      assigned_by: EcoCyc
  - go_id: GO:0003691
    label: double-stranded telomeric DNA binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 94
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 22
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZAI7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN007664302
  - go_id: GO:0008195
    label: phosphatidate phosphatase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 127
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 24
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A924
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.1.3.4
    - protein: UniProtKB:P0A924
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:27429
  - go_id: GO:0016531
    label: copper chaperone activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 12
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P77214
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:18847219
      assigned_by: EcoCyc
  - go_id: GO:0061770
    label: translation elongation factor binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 1
      Fungi: 13
      Plants: 5
    rate_ratio: 0.0685
    p_value: 0.000883
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39914
      taxon: NCBITaxon:224308
      evidence: IPI
      reference: PMID:33722570
      assigned_by: UniProt
      with_from: UniProtKB:P33166
  - go_id: GO:0071018
    label: U12-type catalytic step 2 spliceosome
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 165
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0686
    p_value: 1.44e-09
    q_value: 7.82e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IGS5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000468991|UniProtKB:Q5RL73
    - protein: UniProtKB:F4K2V9
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000468991|UniProtKB:Q5RL73
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0071018
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071018
  - go_id: GO:0015171
    label: amino acid transmembrane transporter activity
    aspect: MF
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 190
      Archaea: 1
      Bacteria: 79
      Fungi: 55
      Plants: 127
    rate_ratio: 0.0688
    p_value: 4.27e-05
    q_value: 0.000132
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LYY0
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002012871
  - go_id: GO:0061504
    label: cyclic threonylcarbamoyladenosine biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 9
      Fungi: 4
      Plants: 2
    rate_ratio: 0.069
    p_value: 0.00016
    q_value: 0.000449
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QP30
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000180394|PANTHER:PTN001333297|SGD:S000001045|SGD:S000001510|UniProtKB:Q46927
    - protein: UniProtKB:D8SIZ6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000180394|PANTHER:PTN001333297|SGD:S000001045|SGD:S000001510|UniProtKB:Q46927
  - go_id: GO:0051864
    label: histone H3K36 demethylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 100
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QZ95
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1919202|PANTHER:PTN000318179
    - protein: UniProtKB:D8R9X2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1919202|PANTHER:PTN000318179
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0051864
  - go_id: GO:0007088
    label: regulation of mitotic nuclear division
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 109
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O48533
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G57860|PANTHER:PTN008666874
    - protein: UniProtKB:Q9M2R1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G57860|PANTHER:PTN008666874
    - protein: UniProtKB:Q9M2R1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22167058
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007088
  - go_id: GO:0003939
    label: L-iditol 2-dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 31
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:23498864
      assigned_by: UniProt
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: DOI:10.1016/j.plantsci.2013.01.012
      assigned_by: UniProt
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:33031
  - go_id: GO:0046526
    label: D-xylulose reductase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G51970|PANTHER:PTN001707508
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23498864
      assigned_by: TAIR
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.1.1.9
    - protein: UniProtKB:Q9FJ95
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:20433
  - go_id: GO:0010845
    label: positive regulation of reciprocal meiotic recombination
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IDW9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24656236
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0010845
  - go_id: GO:0052642
    label: lysophosphatidic acid phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 42
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SRQ6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G03520|PANTHER:PTN008642411
    - protein: UniProtKB:Q9SRQ6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:20045079
      assigned_by: TAIR
    - protein: UniProtKB:Q9SRQ6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.1.3.106
    - protein: UniProtKB:Q9SRQ6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:33155
  - go_id: GO:0032210
    label: regulation of telomere maintenance via telomerase
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 31
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q56Y52
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G05210|PANTHER:PTN000376531|SGD:S000002379|UniProtKB:Q9NUX5
    - protein: UniProtKB:Q6NKX5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G05210|PANTHER:PTN000376531|SGD:S000002379|UniProtKB:Q9NUX5
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0032210
  - go_id: GO:0016247
    label: channel regulator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 52
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P18064
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:11408655
      assigned_by: TAIR
  - go_id: GO:0103026
    label: fructose-1-phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZVJ5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:35603
  - go_id: GO:0032197
    label: retrotransposition
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 6
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XFH4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19734880
      assigned_by: TAIR
  - go_id: GO:0046337
    label: phosphatidylethanolamine metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C6B9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29777000
      assigned_by: TAIR
  - go_id: GO:0015247
    label: aminophospholipid flippase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 12
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XIE6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18344284
      assigned_by: TAIR
    - protein: UniProtKB:Q9XIE6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:32817253
      assigned_by: TAIR
  - go_id: GO:0033597
    label: mitotic checkpoint complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 18
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9S7I8
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:21687678
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G25980
    - protein: UniProtKB:Q9SZA4
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:21687678
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G25980
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0033597
  - go_id: GO:1900103
    label: positive regulation of endoplasmic reticulum unfolded protein response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SCK6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24961665
      assigned_by: TAIR
  - go_id: GO:0110152
    label: RNA NAD+-cap (NAD+-forming) hydrolase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8RY73
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:30949699
      assigned_by: UniProt
    - protein: UniProtKB:Q8RY73
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:60880
  - go_id: GO:0080007
    label: S-nitrosoglutathione reductase (NADH) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 7
      Archaea: 0
      Bacteria: 3
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96533
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:38308388
      assigned_by: UniProt
    - protein: UniProtKB:Q96533
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:78371
    - protein: UniProtKB:Q96533
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18326829
      assigned_by: TAIR
  - go_id: GO:0033721
    label: aldehyde dehydrogenase (NADP+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 9
      Archaea: 0
      Bacteria: 2
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8W033
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:21166653
      assigned_by: TAIR
  - go_id: GO:0004059
    label: aralkylamine N-acetyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7X9V3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25250906
      assigned_by: TAIR
    - protein: UniProtKB:Q7X9V3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.1.87
    - protein: UniProtKB:Q7X9V3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: EnsemblPlants
      with_from: UniProtKB:Q5KQI6|RAP2022-09-01:Os05t0481000-01
    - protein: UniProtKB:Q7X9V3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:66144|RHEA:25217
    - protein: UniProtKB:Q9C666
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31698875
      assigned_by: UniProt
    - protein: UniProtKB:Q9C666
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.1.87
  - go_id: GO:0015805
    label: S-adenosyl-L-methionine transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 7
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94AG6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17098813
      assigned_by: TAIR
  - go_id: GO:0004741
    label: '[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity'
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 13
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O81760
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33798747
      assigned_by: TAIR
  - go_id: GO:1903754
    label: cortical microtubule plus-end
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 14
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9MA92
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25541219
      assigned_by: TAIR
    - protein: UniProtKB:Q9SFF4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25541219
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1903754
  - go_id: GO:0060211
    label: regulation of nuclear-transcribed mRNA poly(A) tail shortening
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 8
      Plants: 2
    rate_ratio: 0.0691
    p_value: 0.000283
    q_value: 0.000762
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O64380
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:14624004
      assigned_by: UniProt
    - protein: UniProtKB:P42731
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:10849337
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0060211
  - go_id: GO:0047434
    label: indolepyruvate decarboxylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LFM5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22233288
      assigned_by: TAIR
  - go_id: GO:2000185
    label: regulation of phosphate transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 1
    rate_ratio: 0.0691
    p_value: 0.0182
    q_value: 0.0329
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VY10
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:24122829
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G52190
    - protein: UniProtKB:Q8VY10
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:24122829
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G43360
    - protein: UniProtKB:Q8VY10
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:24122829
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G43370
  - go_id: GO:0006825
    label: copper ion transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 57
      Archaea: 1
      Bacteria: 8
      Fungi: 12
      Plants: 3
    rate_ratio: 0.0691
    p_value: 4.94e-06
    q_value: 1.73e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B9DFX7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15772282
      assigned_by: TAIR
    - protein: UniProtKB:Q39065
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:7499355
      assigned_by: TAIR
      with_from: SGD:S000006328
    - protein: UniProtKB:Q94FT1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:12196180
      assigned_by: TAIR
  - go_id: GO:0043254
    label: regulation of protein-containing complex assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 114
      Archaea: 0
      Bacteria: 1
      Fungi: 12
      Plants: 3
    rate_ratio: 0.0691
    p_value: 4.94e-06
    q_value: 1.73e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P92973
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20007447
      assigned_by: TAIR
      gene_review: genes/ARATH/CCA1/CCA1-ai-review.yaml
    - protein: UniProtKB:Q9FFA7
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23277547
      assigned_by: TAIR
    - protein: UniProtKB:Q9FFA7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086482
    - protein: UniProtKB:Q9LTJ6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23277547
      assigned_by: TAIR
    - protein: UniProtKB:Q9LTJ6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086482
  - go_id: GO:0001223
    label: transcription coactivator binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 294
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0696
    p_value: 2.39e-05
    q_value: 7.63e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P39521
      taxon: NCBITaxon:559292
      evidence: IPI
      reference: PMID:15620355
      assigned_by: SGD
      with_from: SGD:S000004213
  - go_id: GO:0071396
    label: cellular response to lipid
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 162
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0698
    p_value: 2.27e-09
    q_value: 1.2e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O80920
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027803
    - protein: UniProtKB:Q8S8E3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027803
  - go_id: GO:0003870
    label: 5-aminolevulinate synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 81
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0698
    p_value: 4.94e-05
    q_value: 0.00015
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R4V5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000189686|MGI:MGI:87989|MGI:MGI:87990|PANTHER:PTN000343737|PomBase:SPAC2F3.09|RGD:2084|RGD:68392|SGD:S000002640|UniProtKB:P13196|UniProtKB:P22557|UniProtKB:Q8I4X1
  - go_id: GO:0031334
    label: positive regulation of protein-containing complex assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 243
      Archaea: 0
      Bacteria: 1
      Fungi: 1
      Plants: 3
    rate_ratio: 0.0698
    p_value: 1.17e-13
    q_value: 8.92e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4J1U2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30012777
      assigned_by: TAIR
    - protein: UniProtKB:F4J2Z0
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:30012777
      assigned_by: TAIR
    - protein: UniProtKB:F4K2E9
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:25902521
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G01040
  - go_id: GO:0015764
    label: N-acetylglucosamine transport
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 16
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0702
    p_value: 0.000643
    q_value: 0.0016
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5A7S4
      taxon: NCBITaxon:237561
      evidence: IDA
      reference: PMID:17192409
      assigned_by: CGD
    - protein: UniProtKB:Q5A7S4
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:17192409
      assigned_by: CGD
  - go_id: GO:0055088
    label: lipid homeostasis
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 235
      Archaea: 0
      Bacteria: 3
      Fungi: 38
      Plants: 19
    rate_ratio: 0.0703
    p_value: 1.27e-09
    q_value: 6.89e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P27247
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:39475235
      assigned_by: EcoCyc
    - protein: UniProtKB:P52645
      taxon: NCBITaxon:83333
      evidence: IGI
      reference: PMID:34781743
      assigned_by: UniProt
      with_from: UniProtKB:P39321|UniProtKB:P46474
    - protein: UniProtKB:P60782
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:39475235
      assigned_by: EcoCyc
  - go_id: GO:0008630
    label: intrinsic apoptotic signaling pathway in response to DNA damage
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 291
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0703
    p_value: 2.73e-05
    q_value: 8.66e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PLT8
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:40915675
      assigned_by: CGD
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0008630
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0008630
  - go_id: GO:0000234
    label: phosphoethanolamine N-methyltransferase activity
    aspect: MF
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 5
    rate_ratio: 0.0707
    p_value: 0.00246
    q_value: 0.00544
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q22993
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.103
    - protein: UniProtKB:Q23552
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:17313371
      assigned_by: WB
    - protein: UniProtKB:Q23552
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.103
    - protein: UniProtKB:Q23552
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00098314
  - go_id: GO:0005452
    label: solute:inorganic anion antiporter activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 256
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 18
    rate_ratio: 0.0712
    p_value: 3.29e-05
    q_value: 0.000103
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10903
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:25959928
      assigned_by: EcoCyc
  - go_id: GO:0031648
    label: protein destabilization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 256
      Archaea: 0
      Bacteria: 1
      Fungi: 4
      Plants: 4
    rate_ratio: 0.0712
    p_value: 3.29e-05
    q_value: 0.000103
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AEV1
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:8635466
      assigned_by: EcoCyc
    - protein: UniProtKB:P0AEV1
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:8637901
      assigned_by: EcoCyc
  - go_id: GO:0045792
    label: negative regulation of cell size
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 79
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0716
    p_value: 6.68e-05
    q_value: 0.0002
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IME8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19962211
      assigned_by: TAIR
  - go_id: GO:0006208
    label: pyrimidine nucleobase catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 33
      Archaea: 0
      Bacteria: 13
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0716
    p_value: 3.93e-06
    q_value: 1.4e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R305
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G12200|FB:FBgn0023023|PANTHER:PTN000182450|RGD:68376|UniProtKB:Q14117|WB:WBGene00000963|WB:WBGene00000964|dictyBase:DDB_G0269246
    - protein: UniProtKB:D8R305
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086398
    - protein: UniProtKB:D8SMH7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G12200|FB:FBgn0023023|PANTHER:PTN000182450|RGD:68376|UniProtKB:Q14117|WB:WBGene00000963|WB:WBGene00000964|dictyBase:DDB_G0269246
    - protein: UniProtKB:D8SMH7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086398
    - protein: UniProtKB:Q9FMP3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G12200|FB:FBgn0023023|PANTHER:PTN000182450|RGD:68376|UniProtKB:Q14117|WB:WBGene00000963|WB:WBGene00000964|dictyBase:DDB_G0269246
    - protein: UniProtKB:Q9FMP3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086398
  - go_id: GO:0047661
    label: amino-acid racemase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 13
      Fungi: 4
      Plants: 3
    rate_ratio: 0.0716
    p_value: 3.93e-06
    q_value: 1.4e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SNH7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002722431|UniProtKB:P03813|UniProtKB:P22634|UniProtKB:P32960|UniProtKB:P9WPW9
    - protein: UniProtKB:F4JHW0
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26324904
      assigned_by: TAIR
    - protein: UniProtKB:Q9XI28
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002722431|UniProtKB:P03813|UniProtKB:P22634|UniProtKB:P32960|UniProtKB:P9WPW9
    - protein: UniProtKB:Q9XI28
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR015942
    - protein: UniProtKB:Q9XI28
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029237
  - go_id: GO:0019305
    label: dTDP-rhamnose biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 1
      Bacteria: 13
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0716
    p_value: 3.93e-06
    q_value: 1.4e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R443
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G63000|PANTHER:PTN002233786
    - protein: UniProtKB:Q9LQ04
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G63000|PANTHER:PTN002233786
    - protein: UniProtKB:Q9LQ04
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15020741
      assigned_by: TAIR
    - protein: UniProtKB:Q9LQ04
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00124
    - protein: UniProtKB:Q9LZI2
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:11554483
      assigned_by: TAIR
  - go_id: GO:0019236
    label: response to pheromone
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 157
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 2
    rate_ratio: 0.072
    p_value: 4.83e-09
    q_value: 2.48e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P18064
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:29702752
      assigned_by: UniProt
    - protein: UniProtKB:Q94AH1
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:29702752
      assigned_by: UniProt
    - protein: UniProtKB:Q94AH1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:29702752
      assigned_by: UniProt
  - go_id: GO:0051019
    label: mitogen-activated protein kinase binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 157
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 2
    rate_ratio: 0.072
    p_value: 4.83e-09
    q_value: 2.48e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FJV0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:30185442
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G01370
    - protein: UniProtKB:Q9MA75
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:17947581
      assigned_by: UniProt
      with_from: UniProtKB:Q39023
  - go_id: GO:0051959
    label: dynein light intermediate chain binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 252
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 16
    rate_ratio: 0.0723
    p_value: 4.01e-05
    q_value: 0.000124
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZKN9
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000436624
  - go_id: GO:0045806
    label: negative regulation of endocytosis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 156
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0725
    p_value: 5.61e-09
    q_value: 2.85e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0WQ57
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29511054
      assigned_by: TAIR
    - protein: UniProtKB:Q0WQ57
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:29511054
      assigned_by: TAIR
    - protein: UniProtKB:Q9SU08
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29511054
      assigned_by: TAIR
  - go_id: GO:0008375
    label: acetylglucosaminyltransferase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 251
      Archaea: 0
      Bacteria: 1
      Fungi: 2
      Plants: 28
    rate_ratio: 0.0726
    p_value: 4.22e-05
    q_value: 0.00013
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P75905
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR023853
    - protein: UniProtKB:P75905
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:18359807
      assigned_by: EcoCyc
    - protein: UniProtKB:P75905
      taxon: NCBITaxon:83333
      evidence: RCA
      reference: PMID:15090514
      assigned_by: EcoCyc
  - go_id: GO:0051219
    label: phosphoprotein binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 250
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0729
    p_value: 4.43e-05
    q_value: 0.000136
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A9H9
      taxon: NCBITaxon:83333
      evidence: IPI
      reference: PMID:8305438
      assigned_by: EcoCyc
      with_from: EcoCyc:PHOSPHO-CHEY
      gene_review: genes/ECOLI/cheZ/cheZ-ai-review.yaml
  - go_id: GO:0051983
    label: regulation of chromosome segregation
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 249
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 7
    rate_ratio: 0.0732
    p_value: 4.66e-05
    q_value: 0.000142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A9X4
      taxon: NCBITaxon:83333
      evidence: IGI
      reference: PMID:19187760
      assigned_by: EcoliWiki
      with_from: EcoliWiki:mreC|EcoliWiki:mreD
    - protein: UniProtKB:P0A9X4
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:14517265
      assigned_by: EcoliWiki
  - go_id: GO:0009314
    label: response to radiation
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 98
      Archaea: 0
      Bacteria: 46
      Fungi: 3
      Plants: 11
    rate_ratio: 0.0733
    p_value: 7.9e-10
    q_value: 4.39e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PGZ5
      taxon: NCBITaxon:237561
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G44740|FB:FBgn0037141|MGI:MGI:1891457|PANTHER:PTN000117879|UniProtKB:Q9Y253
    - protein: UniProtKB:A0A1D8PGZ5
      taxon: NCBITaxon:237561
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001301238
    - protein: UniProtKB:O42917
      taxon: NCBITaxon:284812
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G44740|FB:FBgn0037141|MGI:MGI:1891457|PANTHER:PTN000117879|UniProtKB:Q9Y253
    - protein: UniProtKB:Q04049
      taxon: NCBITaxon:559292
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G44740|FB:FBgn0037141|MGI:MGI:1891457|PANTHER:PTN000117879|UniProtKB:Q9Y253
  - go_id: GO:0002933
    label: lipid hydroxylation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 77
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0735
    p_value: 9.04e-05
    q_value: 0.000264
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LNJ4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN005383291|UniProtKB:Q7EZR4
  - go_id: GO:0035720
    label: intraciliary anterograde transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 154
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0735
    p_value: 7.59e-09
    q_value: 3.78e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T911
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000381369|UniProtKB:Q57ZL2
    - protein: UniProtKB:D8TD01
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000381369|UniProtKB:Q57ZL2
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0035720
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0035720
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0035720
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0035720
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0035720
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0035720
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0035720
  - go_id: GO:0034705
    label: potassium channel complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 77
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0735
    p_value: 9.04e-05
    q_value: 0.000264
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SVV6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31201323
      assigned_by: TAIR
  - go_id: GO:0034595
    label: phosphatidylinositol phosphate 5-phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 77
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0735
    p_value: 9.04e-05
    q_value: 0.000264
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SIS4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23658066
      assigned_by: TAIR
  - go_id: GO:0019898
    label: extrinsic component of membrane
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 54
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 49
    rate_ratio: 0.0739
    p_value: 0.000149
    q_value: 0.000422
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O94628
      taxon: NCBITaxon:284812
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: PomBase
      with_from: UniProtKB:P27680
  - go_id: GO:0061157
    label: mRNA destabilization
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 177
      Archaea: 0
      Bacteria: 1
      Fungi: 12
      Plants: 9
    rate_ratio: 0.0742
    p_value: 0.00175
    q_value: 0.00397
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q46865
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:19690171
      assigned_by: EcoCyc
  - go_id: GO:0071596
    label: ubiquitin-dependent protein catabolic process via the N-end rule pathway
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 118
      Archaea: 0
      Bacteria: 1
      Fungi: 12
      Plants: 10
    rate_ratio: 0.0742
    p_value: 0.00175
    q_value: 0.00397
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q02NB0
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017138
  - go_id: GO:0004737
    label: pyruvate decarboxylase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 12
      Plants: 12
    rate_ratio: 0.0742
    p_value: 0.00175
    q_value: 0.00397
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:H9L492
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008451158|SGD:S000003319|SGD:S000004034|SGD:S000004124
    - protein: UniProtKB:H9L492
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.1.1.1|EC:4.1.1.1
  - go_id: GO:0031113
    label: regulation of microtubule polymerization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 76
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0744
    p_value: 0.000105
    q_value: 0.000303
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96262
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G20260|PANTHER:PTN008673654
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031113
  - go_id: GO:0040015
    label: negative regulation of multicellular organism growth
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 76
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0744
    p_value: 0.000105
    q_value: 0.000303
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LFS4
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19112492
      assigned_by: CAFA
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0040015
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0040015
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0040015
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0040015
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0040015
  - go_id: GO:0009247
    label: glycolipid biosynthetic process
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 112
      Archaea: 0
      Bacteria: 15
      Fungi: 1
      Plants: 19
    rate_ratio: 0.0749
    p_value: 0.00115
    q_value: 0.00271
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P14020
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026760
      gene_review: genes/yeast/DPM1/DPM1-ai-review.yaml
  - go_id: GO:0008808
    label: cardiolipin synthase activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 15
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0749
    p_value: 0.00115
    q_value: 0.00271
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O13899
      taxon: NCBITaxon:284812
      evidence: ISO
      reference: GO_REF:0000024
      assigned_by: PomBase
      with_from: SGD:S000002301
      gene_review: genes/SCHPO/crd1/crd1-ai-review.yaml
  - go_id: GO:0006986
    label: response to unfolded protein
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 121
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 3
    rate_ratio: 0.0754
    p_value: 1.84e-05
    q_value: 5.97e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S2V7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086617
    - protein: UniProtKB:D8S8C5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086617
    - protein: UniProtKB:Q9SG86
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:18156219
      assigned_by: TAIR
  - go_id: GO:0016460
    label: myosin II complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 192
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 3
    rate_ratio: 0.0754
    p_value: 1.84e-05
    q_value: 5.97e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R3G0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0002772|FB:FBgn0004687|PANTHER:PTN000549249|PomBase:SPAP8A3.08|SGD:S000003074|UniProtKB:P02607|dictyBase:DDB_G0277859
    - protein: UniProtKB:D8R9M6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0287873|MGI:MGI:102643|MGI:MGI:107717|MGI:MGI:1930780|PANTHER:PTN005210253|PomBase:SPCC645.05c|RGD:62029|RGD:62030|SGD:S000001065|UniProtKB:P10587|UniProtKB:P12882|UniProtKB:P35579|UniProtKB:P35580|UniProtKB:Q7Z406|WB:WBGene00006789|dictyBase:DDB_G0286355
    - protein: UniProtKB:D8SI49
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0002772|FB:FBgn0004687|PANTHER:PTN000549249|PomBase:SPAP8A3.08|SGD:S000003074|UniProtKB:P02607|dictyBase:DDB_G0277859
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0016460
  - go_id: GO:0000417
    label: HIR complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 3
    rate_ratio: 0.0754
    p_value: 1.84e-05
    q_value: 5.97e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RWR3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000197832|PANTHER:PTN000352669|PomBase:SPBC15D4.03|PomBase:SPBC31F10.13c|SGD:S000000104|SGD:S000005564|UniProtKB:P54198
    - protein: UniProtKB:D8S688
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000197832|PANTHER:PTN000352669|PomBase:SPBC15D4.03|PomBase:SPBC31F10.13c|SGD:S000000104|SGD:S000005564|UniProtKB:P54198
    - protein: UniProtKB:Q9LXN4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000197832|PANTHER:PTN000352669|PomBase:SPBC15D4.03|PomBase:SPBC31F10.13c|SGD:S000000104|SGD:S000005564|UniProtKB:P54198
  - go_id: GO:0120330
    label: rixosome complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 3
    rate_ratio: 0.0754
    p_value: 1.84e-05
    q_value: 5.97e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RTJ1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000428096|PomBase:SPAC13G7.08c|SGD:S000005126|UniProtKB:Q9BV38
    - protein: UniProtKB:D8SQZ5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000428096|PomBase:SPAC13G7.08c|SGD:S000005126|UniProtKB:Q9BV38
    - protein: UniProtKB:Q9M3B4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000428096|PomBase:SPAC13G7.08c|SGD:S000005126|UniProtKB:Q9BV38
  - go_id: GO:0010520
    label: regulation of reciprocal meiotic recombination
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 11
      Plants: 3
    rate_ratio: 0.0754
    p_value: 1.84e-05
    q_value: 5.97e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P16128
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:41254312
      assigned_by: TAIR
    - protein: UniProtKB:Q8GW48
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:35670129
      assigned_by: TAIR
    - protein: UniProtKB:Q9FGW5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:32047050
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0010520
  - go_id: GO:0051410
    label: detoxification of nitrogen compound
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 7
    rate_ratio: 0.0758
    p_value: 0.000272
    q_value: 0.000735
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5VT66
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:20861021
      assigned_by: UniProt
    - protein: UniProtKB:Q969Z3
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:20861021
      assigned_by: UniProt
    - protein: UniProtKB:Q9VGT0
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:41344624
      assigned_by: FlyBase
  - go_id: GO:0007162
    label: negative regulation of cell adhesion
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 270
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0758
    p_value: 6.94e-05
    q_value: 0.000207
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q59V88
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:38183361
      assigned_by: CGD
  - go_id: GO:0008154
    label: actin polymerization or depolymerization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 149
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0759
    p_value: 1.61e-08
    q_value: 7.73e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q42418
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8647830
      assigned_by: TAIR
    - protein: UniProtKB:Q42449
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8647830
      assigned_by: TAIR
  - go_id: GO:0005245
    label: voltage-gated calcium channel activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 538
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 8
    rate_ratio: 0.0761
    p_value: 4.89e-09
    q_value: 2.51e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O14234
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002077
    - protein: UniProtKB:P50077
      taxon: NCBITaxon:559292
      evidence: ISS
      reference: PMID:9343395
      assigned_by: SGD
      with_from: UniProtKB:P22002
  - go_id: GO:0045861
    label: negative regulation of proteolysis
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 238
      Archaea: 0
      Bacteria: 1
      Fungi: 7
      Plants: 0
    rate_ratio: 0.0766
    p_value: 8.04e-05
    q_value: 0.000237
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AEM4
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:17537210
      assigned_by: EcoCyc
  - go_id: GO:0045948
    label: positive regulation of translational initiation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 220
      Archaea: 0
      Bacteria: 3
      Fungi: 10
      Plants: 3
    rate_ratio: 0.0771
    p_value: 3.72e-12
    q_value: 2.54e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A8MR55
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:36801014
      assigned_by: TAIR
    - protein: UniProtKB:Q9C5Z2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:15548739
      assigned_by: UniProt
    - protein: UniProtKB:Q9C5Z2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23524850
      assigned_by: UniProt
    - protein: UniProtKB:Q9M0V1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:36801014
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045948
  - go_id: GO:0006301
    label: DNA damage tolerance
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 67
      Archaea: 0
      Bacteria: 2
      Fungi: 23
      Plants: 20
    rate_ratio: 0.0774
    p_value: 5.44e-06
    q_value: 1.9e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P33919
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:31665437
      assigned_by: EcoCyc
    - protein: UniProtKB:P43672
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:31665437
      assigned_by: EcoCyc
  - go_id: GO:0045022
    label: early endosome to late endosome transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 219
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0775
    p_value: 4.32e-12
    q_value: 2.93e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S6P2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001193267|UniProtKB:Q96NW4
    - protein: UniProtKB:F4IJ68
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000359150|SGD:S000003794
    - protein: UniProtKB:Q9CB01
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:11532937
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045022
  - go_id: GO:0004515
    label: nicotinate-nucleotide adenylyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 8
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0776
    p_value: 0.000556
    q_value: 0.0014
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QTW4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G55810|MGI:MGI:1913704|MGI:MGI:2444155|PANTHER:PTN000247701|UniProtKB:P0A752|UniProtKB:Q96T66|UniProtKB:Q9BZQ4|UniProtKB:Q9HAN9
    - protein: UniProtKB:D8QTW4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.7.18|EC:2.7.7.18
    - protein: UniProtKB:F4K687
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G55810|MGI:MGI:1913704|MGI:MGI:2444155|PANTHER:PTN000247701|UniProtKB:P0A752|UniProtKB:Q96T66|UniProtKB:Q9BZQ4|UniProtKB:Q9HAN9
    - protein: UniProtKB:F4K687
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:17270012
      assigned_by: TAIR
    - protein: UniProtKB:F4K687
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045094
    - protein: UniProtKB:F4K687
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.7.7.18
    - protein: UniProtKB:F4K687
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:22860
    - protein: UniProtKB:F4K687
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9HAN9
  - go_id: GO:0019200
    label: carbohydrate kinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 11
      Archaea: 0
      Bacteria: 4
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6ZY51
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:15686522
      assigned_by: TAIR
  - go_id: GO:0050355
    label: inorganic triphosphate phosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 8
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SIY3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G11890|PANTHER:PTN001842862
    - protein: UniProtKB:Q9SIY3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:24004165
      assigned_by: TAIR
    - protein: UniProtKB:Q9SIY3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:24004165
      assigned_by: UniProt
    - protein: UniProtKB:Q9SIY3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.6.1.25
    - protein: UniProtKB:Q9SIY3
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:14157
  - go_id: GO:0031402
    label: sodium ion binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 40
      Archaea: 1
      Bacteria: 8
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0776
    p_value: 0.000556
    q_value: 0.0014
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9S795
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:20026072
      assigned_by: UniProt
      with_from: UniProtKB:Q8VWZ1
    - protein: UniProtKB:Q9STS1
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:20026072
      assigned_by: UniProt
      with_from: UniProtKB:Q8VWZ1
  - go_id: GO:1903810
    label: L-histidine import across plasma membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 8
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FKS8
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:9390441
      assigned_by: UniProt
  - go_id: GO:0110153
    label: RNA NAD-cap (NMN-forming) hydrolase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 8
      Archaea: 0
      Bacteria: 4
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94A82
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:60876
    - protein: UniProtKB:Q94A82
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9DCN1
  - go_id: GO:0042882
    label: L-arabinose transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O04249
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:29311272
      assigned_by: TAIR
  - go_id: GO:1903805
    label: L-valine import across plasma membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q84MA5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:8618839
      assigned_by: UniProt
  - go_id: GO:0017003
    label: protein-heme linkage
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96326
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004329|InterPro:IPR036127
  - go_id: GO:0004808
    label: tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GUP2
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:36762482
      assigned_by: UniProt
    - protein: UniProtKB:Q8GUP2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.61
  - go_id: GO:0030638
    label: polyketide metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0776
    p_value: 0.0255
    q_value: 0.0444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LK50
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:25415974
      assigned_by: UniProt
  - go_id: GO:0009450
    label: GABA catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 17
      Archaea: 1
      Bacteria: 12
      Fungi: 10
      Plants: 3
    rate_ratio: 0.0776
    p_value: 1.36e-05
    q_value: 4.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008681047|SGD:S000000210|UniProtKB:P25526|UniProtKB:P51649
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010102
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00733
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001051784
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008681047|SGD:S000000210|UniProtKB:P25526|UniProtKB:P51649
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010102
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00733
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001051784
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008681047|SGD:S000000210|UniProtKB:P25526|UniProtKB:P51649
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR010102
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00733
  - go_id: GO:0015851
    label: nucleobase transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 12
      Fungi: 2
      Plants: 3
    rate_ratio: 0.0776
    p_value: 1.36e-05
    q_value: 4.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RGZ2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015205
    - protein: UniProtKB:D8S5K2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015205
    - protein: UniProtKB:Q9LZD0
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015205
  - go_id: GO:0044038
    label: cell wall macromolecule biosynthetic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 12
      Fungi: 7
      Plants: 3
    rate_ratio: 0.0776
    p_value: 1.36e-05
    q_value: 4.5e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SF52
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000531998|UniProtKB:P0AC78|UniProtKB:Q9X1N5
    - protein: UniProtKB:D8SRQ9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000531998|UniProtKB:P0AC78|UniProtKB:Q9X1N5
    - protein: UniProtKB:O49730
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000531998|UniProtKB:P0AC78|UniProtKB:Q9X1N5
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0044038
  - go_id: GO:0000290
    label: deadenylation-dependent decapping of nuclear-transcribed mRNA
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 132
      Archaea: 0
      Bacteria: 3
      Fungi: 34
      Plants: 23
    rate_ratio: 0.0785
    p_value: 1.89e-08
    q_value: 9.0e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O25826
      taxon: NCBITaxon:85962
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036534|PANTHER:PTN000561806|PomBase:SPAC19A8.12|SGD:S000005062|WB:WBGene00003582
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000290
    - protein: UniProtKB:P0A776
      taxon: NCBITaxon:83333
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036534|PANTHER:PTN000561806|PomBase:SPAC19A8.12|SGD:S000005062|WB:WBGene00003582
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000290
    - protein: UniProtKB:P65554
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036534|PANTHER:PTN000561806|PomBase:SPAC19A8.12|SGD:S000005062|WB:WBGene00003582
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000290
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000290
  - go_id: GO:0001881
    label: receptor recycling
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 72
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0786
    p_value: 0.000192
    q_value: 0.000533
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9STT2
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23263768
      assigned_by: TAIR
  - go_id: GO:0003376
    label: sphingosine-1-phosphate receptor signaling pathway
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 72
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0786
    p_value: 0.000192
    q_value: 0.000533
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P18064
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:12789341
      assigned_by: TAIR
  - go_id: GO:0071821
    label: FANCM-MHF complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 29
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0789
    p_value: 0.00105
    q_value: 0.0025
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L7N3
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002010747|PomBase:SPCC576.12c|SGD:S000028520|UniProtKB:A8MT69
    - protein: UniProtKB:Q9FI55
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000541279|PomBase:SPBC2D10.16|SGD:S000007626|UniProtKB:Q8N2Z9
    - protein: UniProtKB:Q9FI55
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR029003
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071821
  - go_id: GO:0042758
    label: long-chain fatty acid catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 35
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0789
    p_value: 0.00105
    q_value: 0.0025
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QSL3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001659973|UniProtKB:Q96IZ2|UniProtKB:Q9NVV5
    - protein: UniProtKB:D8R1T3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001659973|UniProtKB:Q96IZ2|UniProtKB:Q9NVV5
  - go_id: GO:0008287
    label: protein serine/threonine phosphatase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 58
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0789
    p_value: 0.00105
    q_value: 0.0025
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O04719
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:9869399
      assigned_by: TIGR
    - protein: UniProtKB:P49597
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:9869399
      assigned_by: TIGR
      gene_review: genes/ARATH/ABI1/ABI1-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0008287
  - go_id: GO:0070935
    label: 3'-UTR-mediated mRNA stabilization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 110
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0789
    p_value: 0.00105
    q_value: 0.0025
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8AXB9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28174577
      assigned_by: TAIR
    - protein: UniProtKB:Q8S8K1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28174577
      assigned_by: TAIR
  - go_id: GO:0071243
    label: cellular response to arsenic-containing substance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 34
      Archaea: 0
      Bacteria: 1
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0789
    p_value: 0.00105
    q_value: 0.0025
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8BC92
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34778748
      assigned_by: TAIR
    - protein: UniProtKB:F4K6R6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:34778748
      assigned_by: TAIR
  - go_id: GO:0070127
    label: tRNA aminoacylation for mitochondrial protein translation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 12
      Archaea: 0
      Bacteria: 0
      Fungi: 7
      Plants: 2
    rate_ratio: 0.0789
    p_value: 0.00105
    q_value: 0.0025
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4I4Z2
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375824
    - protein: UniProtKB:P36428
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000375824
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070127
  - go_id: GO:0016589
    label: NURF complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 142
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0797
    p_value: 4.59e-08
    q_value: 2.1e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RE40
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR038028
    - protein: UniProtKB:D8STZ1
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR038028
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0016589
  - go_id: GO:0017064
    label: fatty acid amide hydrolase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 71
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0797
    p_value: 0.000223
    q_value: 0.000611
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7XJJ7
      taxon: NCBITaxon:3702
      evidence: EXP
      reference: PMID:12824167
      assigned_by: UniProt
    - protein: UniProtKB:Q7XJJ7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.5.1.99
    - protein: UniProtKB:Q7XJJ7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:26136
  - go_id: GO:0098754
    label: detoxification
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 71
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0797
    p_value: 0.000223
    q_value: 0.000611
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZQ94
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:12970342
      assigned_by: UniProt
      gene_review: genes/ARATH/UGT73C5/UGT73C5-ai-review.yaml
  - go_id: GO:0044020
    label: histone H4R3 methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 71
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0797
    p_value: 0.000223
    q_value: 0.000611
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9MAT5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18007657
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0044020
  - go_id: GO:0140318
    label: protein transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 71
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0797
    p_value: 0.000223
    q_value: 0.000611
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q93Z75
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:31862838
      assigned_by: TAIR
  - go_id: GO:0042545
    label: cell wall modification
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 3
      Plants: 136
    rate_ratio: 0.0798
    p_value: 3.76e-11
    q_value: 2.33e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PMG9
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:40531863
      assigned_by: CGD
    - protein: UniProtKB:P0CY33
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:40531863
      assigned_by: CGD
    - protein: UniProtKB:Q5A1D3
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:40531863
      assigned_by: CGD
      gene_review: genes/CANAL/CEK1/CEK1-ai-review.yaml
  - go_id: GO:0045182
    label: translation regulator activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 196
      Archaea: 0
      Bacteria: 2
      Fungi: 22
      Plants: 14
    rate_ratio: 0.0809
    p_value: 1.07e-05
    q_value: 3.58e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P62395
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:15302932
      assigned_by: EcoCyc
    - protein: UniProtKB:P62395
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR009502
    - protein: UniProtKB:Q8ZRT8
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR009502
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045182
  - go_id: GO:0016125
    label: sterol metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 163
      Archaea: 0
      Bacteria: 2
      Fungi: 22
      Plants: 41
    rate_ratio: 0.0809
    p_value: 1.07e-05
    q_value: 3.58e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34539
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G43620|AGI_LocusCode:AT3G07020|PANTHER:PTN005367244|SGD:S000004179|dictyBase:DDB_G0288655
    - protein: UniProtKB:Q8ZMN4
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G43620|AGI_LocusCode:AT3G07020|PANTHER:PTN005367244|SGD:S000004179|dictyBase:DDB_G0288655
  - go_id: GO:0046839
    label: phospholipid dephosphorylation
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 80
      Archaea: 0
      Bacteria: 1
      Fungi: 11
      Plants: 17
    rate_ratio: 0.0809
    p_value: 0.00345
    q_value: 0.00744
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P18200
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:2846510
      assigned_by: UniProt
    - protein: UniProtKB:P18200
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:21148555
      assigned_by: UniProt
  - go_id: GO:0051999
    label: mannosyl-inositol phosphorylceramide biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 11
      Plants: 0
    rate_ratio: 0.0809
    p_value: 0.00345
    q_value: 0.00744
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q183L1
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001738823
  - go_id: GO:0140684
    label: histone H3K9me2/H3K9me3 demethylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 69
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.082
    p_value: 0.000301
    q_value: 0.000798
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8RWR1
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:29923261
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0140684
  - go_id: GO:0016469
    label: proton-transporting two-sector ATPase complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 69
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.082
    p_value: 0.000301
    q_value: 0.000798
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O82628
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:11004467
      assigned_by: TAIR
  - go_id: GO:0071360
    label: cellular response to exogenous dsRNA
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 69
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.082
    p_value: 0.000301
    q_value: 0.000798
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SIW2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21771120
      assigned_by: UniProt
  - go_id: GO:0097110
    label: scaffold protein binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 444
      Archaea: 0
      Bacteria: 2
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0821
    p_value: 2.91e-08
    q_value: 1.36e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34894
      taxon: NCBITaxon:224308
      evidence: IPI
      reference: PMID:18363795
      assigned_by: UniProt
      with_from: UniProtKB:P0CI74
    - protein: UniProtKB:P39793
      taxon: NCBITaxon:224308
      evidence: IPI
      reference: PMID:18363795
      assigned_by: UniProt
      with_from: UniProtKB:P0CI74
  - go_id: GO:0005164
    label: tumor necrosis factor receptor binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 205
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0828
    p_value: 3.49e-11
    q_value: 2.17e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S6Y7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002379609|UniProtKB:O94972
    - protein: UniProtKB:D8SSY4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002379609|UniProtKB:O94972
    - protein: UniProtKB:D8T7F6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002379609|UniProtKB:O94972
  - go_id: GO:0043425
    label: bHLH transcription factor binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 205
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0828
    p_value: 3.49e-11
    q_value: 2.17e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O49687
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:21335373
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT5G46760
    - protein: UniProtKB:Q9FIP9
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:21335373
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G17880
      gene_review: genes/ARATH/MYC3/MYC3-ai-review.yaml
    - protein: UniProtKB:Q9ZPW3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:23221598
      assigned_by: TAIR
  - go_id: GO:0019211
    label: phosphatase activator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 54
      Archaea: 0
      Bacteria: 0
      Fungi: 10
      Plants: 3
    rate_ratio: 0.0829
    p_value: 6.71e-05
    q_value: 0.000201
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SYB5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004327|InterPro:IPR037218
    - protein: UniProtKB:D8T749
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004327|InterPro:IPR037218
    - protein: UniProtKB:F4JJ86
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004327|InterPro:IPR037218
  - go_id: GO:0110155
    label: NAD-cap decapping
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 29
      Archaea: 0
      Bacteria: 2
      Fungi: 10
      Plants: 3
    rate_ratio: 0.0829
    p_value: 6.71e-05
    q_value: 0.000201
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8T6F9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1890444|PANTHER:PTN000273640|PomBase:SPAC19D5.06c|SGD:S000002778|SGD:S000003215|UniProtKB:O77932
    - protein: UniProtKB:D8T6M0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1890444|PANTHER:PTN000273640|PomBase:SPAC19D5.06c|SGD:S000002778|SGD:S000003215|UniProtKB:O77932
    - protein: UniProtKB:Q8RY73
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1890444|PANTHER:PTN000273640|PomBase:SPAC19D5.06c|SGD:S000002778|SGD:S000003215|UniProtKB:O77932
  - go_id: GO:0000454
    label: snoRNA guided rRNA pseudouridine synthesis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 1
      Fungi: 10
      Plants: 3
    rate_ratio: 0.0829
    p_value: 6.71e-05
    q_value: 0.000201
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R5G8
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000579935|RGD:1563995|SGD:S000001131
    - protein: UniProtKB:Q8VZT0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000579935|RGD:1563995|SGD:S000001131
    - protein: UniProtKB:Q9FK53
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000579935|RGD:1563995|SGD:S000001131
  - go_id: GO:0008395
    label: steroid hydroxylase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 136
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0832
    p_value: 1.12e-07
    q_value: 4.94e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O48786
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G26710|PANTHER:PTN001957721
    - protein: UniProtKB:O48786
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:10611382
      assigned_by: TAIR
    - protein: UniProtKB:Q9M066
      taxon: NCBITaxon:3702
      evidence: TAS
      reference: PMID:9694802
      assigned_by: TIGR
  - go_id: GO:0035102
    label: PRC1 complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 204
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0832
    p_value: 4.05e-11
    q_value: 2.51e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0WX00
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G03770|AGI_LocusCode:AT5G44280|PANTHER:PTN001652016
    - protein: UniProtKB:Q0WX00
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:19097900
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G23380|AGI_LocusCode:AT5G17690
    - protein: UniProtKB:Q0WX00
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:19097900
      assigned_by: UniProt
      with_from: UniProtKB:Q946J8
    - protein: UniProtKB:Q94K49
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT3G63270|PANTHER:PTN002505681
    - protein: UniProtKB:Q94K49
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22837357
      assigned_by: UniProt
    - protein: UniProtKB:Q94K49
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26642436
      assigned_by: UniProt
    - protein: UniProtKB:Q9FKW0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G03770|AGI_LocusCode:AT5G44280|PANTHER:PTN001652016
    - protein: UniProtKB:Q9FKW0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:19097900
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G23380|AGI_LocusCode:AT5G17690
    - protein: UniProtKB:Q9FKW0
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:19097900
      assigned_by: UniProt
      with_from: UniProtKB:Q946J8
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0035102
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0035102
  - go_id: GO:0004698
    label: calcium,diacylglycerol-dependent serine/threonine kinase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 68
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0832
    p_value: 0.000349
    q_value: 0.000914
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6NLQ6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16299177
      assigned_by: TAIR
  - go_id: GO:0008476
    label: protein-tyrosine sulfotransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 68
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0832
    p_value: 0.000349
    q_value: 0.000914
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3EDG5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19666544
      assigned_by: TAIR
    - protein: UniProtKB:Q3EDG5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.8.2.20
    - protein: UniProtKB:Q3EDG5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:16801
  - go_id: GO:0045839
    label: negative regulation of mitotic nuclear division
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 68
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0832
    p_value: 0.000349
    q_value: 0.000914
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LZ78
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17098811
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0045839
  - go_id: GO:0019373
    label: epoxygenase P450 pathway
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 68
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0832
    p_value: 0.000349
    q_value: 0.000914
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96242
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:8378325
      assigned_by: TAIR
  - go_id: GO:0071480
    label: cellular response to gamma radiation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 135
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0838
    p_value: 1.3e-07
    q_value: 5.7e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q0PCS3
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:17227544
      assigned_by: UniProt
    - protein: UniProtKB:Q8RXD4
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:16957774
      assigned_by: UniProt
  - go_id: GO:0036094
    label: small molecule binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 244
      Archaea: 0
      Bacteria: 10
      Fungi: 1
      Plants: 5
    rate_ratio: 0.0839
    p_value: 0.000218
    q_value: 0.000601
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P46670
      taxon: NCBITaxon:559292
      evidence: EXP
      reference: PMID:26208336
      assigned_by: DisProt
  - go_id: GO:0140104
    label: molecular carrier activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 134
      Archaea: 0
      Bacteria: 6
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0844
    p_value: 1.51e-07
    q_value: 6.55e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O80493
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:36322734
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G09157|AGI_LocusCode:AT5G39650
    - protein: UniProtKB:O80493
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:36322734
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT4G11720,AGI_LocusCode:AT5G39650
    - protein: UniProtKB:Q9FK96
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:36322734
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G09157|AGI_LocusCode:AT5G39650
    - protein: UniProtKB:Q9FK96
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:36322734
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G09157,AGI_LocusCode:AT4G11720
  - go_id: GO:1902459
    label: positive regulation of stem cell population maintenance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 134
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0844
    p_value: 1.51e-07
    q_value: 6.55e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22446
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:26028217
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G11260
    - protein: UniProtKB:Q8H1D2
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26028217
      assigned_by: TAIR
      gene_review: genes/ARATH/WOX5/WOX5-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:1902459
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:1902459
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:1902459
  - go_id: GO:0061513
    label: glucose 6-phosphate:phosphate antiporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 51
      Archaea: 0
      Bacteria: 11
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0846
    p_value: 4.61e-05
    q_value: 0.000141
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O23596
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR044740
    - protein: UniProtKB:Q9SA71
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR044740
    - protein: UniProtKB:Q9SL56
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR044740
  - go_id: GO:0070043
    label: rRNA (guanine-N7-)-methyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 11
      Fungi: 1
      Plants: 3
    rate_ratio: 0.0846
    p_value: 4.61e-05
    q_value: 0.000141
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SFJ5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000788684|UniProtKB:P0A6U5
    - protein: UniProtKB:D8TFI1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000788684|UniProtKB:P0A6U5
    - protein: UniProtKB:F4K7J0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000788684|UniProtKB:P0A6U5
  - go_id: GO:0009395
    label: phospholipid catabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 148
      Archaea: 0
      Bacteria: 2
      Fungi: 21
      Plants: 34
    rate_ratio: 0.0848
    p_value: 2.08e-05
    q_value: 6.7e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2ZD79
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002315531
    - protein: UniProtKB:A0A0H2ZIS7
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN002315532
  - go_id: GO:0043269
    label: regulation of monoatomic ion transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9M8U1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:16249341
      assigned_by: TAIR
  - go_id: GO:1902751
    label: positive regulation of cell cycle G2/M phase transition
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:C8KI33
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:19619159
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1902751
  - go_id: GO:0019217
    label: regulation of fatty acid metabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9ZVH7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:31198959
      assigned_by: TAIR
  - go_id: GO:0045178
    label: basal part of cell
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 132
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0857
    p_value: 2.03e-07
    q_value: 8.67e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FG74
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33705718
      assigned_by: UniProt
      gene_review: genes/ARATH/D6PK/D6PK-ai-review.yaml
    - protein: UniProtKB:Q9LU77
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:33705718
      assigned_by: UniProt
      gene_review: genes/ARATH/PIN2/PIN2-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045178
  - go_id: GO:0022849
    label: glutamate-gated calcium ion channel activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9C8E7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:36796359
      assigned_by: TAIR
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0022849
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0022849
  - go_id: GO:0061760
    label: antifungal innate immune response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SQR5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24891605
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0061760
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0061760
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0061760
  - go_id: GO:0097237
    label: cellular response to toxic substance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FFF6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:27637093
      assigned_by: TAIR
  - go_id: GO:0017145
    label: stem cell division
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0857
    p_value: 0.00047
    q_value: 0.0012
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O65020
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17656722
      assigned_by: TAIR
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0017145
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0017145
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0017145
  - go_id: GO:0010468
    label: regulation of gene expression
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 3456
      Archaea: 3
      Bacteria: 78
      Fungi: 67
      Plants: 300
    rate_ratio: 0.086
    p_value: 1.26e-11
    q_value: 8.15e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LX27
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN001676836
    - protein: UniProtKB:Q6M139
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000038431
    - protein: UniProtKB:Q9HJ11
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000038431
  - go_id: GO:0061952
    label: midbody abscission
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 237
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0864
    p_value: 0.000297
    q_value: 0.000789
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P52917
      taxon: NCBITaxon:559292
      evidence: NAS
      reference: PMID:20616062
      assigned_by: ComplexPortal
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0061952
  - go_id: GO:0070063
    label: RNA polymerase binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 123
      Archaea: 0
      Bacteria: 13
      Fungi: 1
      Plants: 8
    rate_ratio: 0.0864
    p_value: 0.00362
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09685
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR045148
  - go_id: GO:0008753
    label: NADPH dehydrogenase (quinone) activity
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 13
      Fungi: 1
      Plants: 5
    rate_ratio: 0.0864
    p_value: 0.00362
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O42909
      taxon: NCBITaxon:284812
      evidence: ISO
      reference: GO_REF:0000024
      assigned_by: PomBase
      with_from: UniProtKB:Q8WWV3
  - go_id: GO:0016655
    label: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 52
      Archaea: 0
      Bacteria: 26
      Fungi: 2
      Plants: 10
    rate_ratio: 0.0864
    p_value: 1.18e-05
    q_value: 3.96e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PHR5
      taxon: NCBITaxon:237561
      evidence: NAS
      reference: PMID:15269278
      assigned_by: CGD
    - protein: UniProtKB:P52923
      taxon: NCBITaxon:559292
      evidence: ISS
      reference: PMID:15381687
      assigned_by: SGD
      with_from: UniProtKB:Q9BRQ8
  - go_id: GO:1904823
    label: purine nucleobase transmembrane transport
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 39
      Archaea: 2
      Bacteria: 13
      Fungi: 1
      Plants: 41
    rate_ratio: 0.0864
    p_value: 0.00362
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O94300
      taxon: NCBITaxon:284812
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027874
  - go_id: GO:0019323
    label: pentose catabolic process
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 2
      Bacteria: 13
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0864
    p_value: 0.00362
    q_value: 0.00777
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PNM8
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:38982056
      assigned_by: CGD
  - go_id: GO:0016117
    label: carotenoid biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 37
    rate_ratio: 0.0871
    p_value: 0.000885
    q_value: 0.00213
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O06728
      taxon: NCBITaxon:224308
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G17230|PANTHER:PTN000770577|UniProtKB:B0KZ40|UniProtKB:B6UV92|UniProtKB:P37294|UniProtKB:P37295|UniProtKB:Q2QLV9|UniProtKB:Q5Z5B7|UniProtKB:Q6EI12
    - protein: UniProtKB:O06728
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028033
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0016117
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0016117
  - go_id: GO:0045259
    label: proton-transporting ATP synthase complex
    aspect: CC
    flagged_taxon: Archaea
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 313
      Archaea: 1
      Bacteria: 62
      Fungi: 52
      Plants: 45
    rate_ratio: 0.0877
    p_value: 0.000603
    q_value: 0.00151
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LYF1
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR000454
  - go_id: GO:0160232
    label: INTAC complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 128
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0884
    p_value: 3.68e-07
    q_value: 1.51e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RL27
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036038|PANTHER:PTN000330295|UniProtKB:Q9NVH2
    - protein: UniProtKB:O49433
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036038|PANTHER:PTN000330295|UniProtKB:Q9NVH2
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0160232
  - go_id: GO:0009956
    label: radial pattern formation
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 3
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 6
    rate_ratio: 0.0884
    p_value: 0.00128
    q_value: 0.00298
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A140LJF1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:15829524
      assigned_by: MGI
      with_from: MGI:MGI:3579117,MGI:MGI:3579118
    - protein: UniProtKB:D3YYP4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:15829524
      assigned_by: MGI
      with_from: MGI:MGI:3579117,MGI:MGI:3579118
    - protein: UniProtKB:P43135
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:15829524
      assigned_by: MGI
      with_from: MGI:MGI:3579117,MGI:MGI:3579118
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0009956
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0009956
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0009956
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0009956
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0009956
  - go_id: GO:0072702
    label: response to methyl methanesulfonate
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 4
    rate_ratio: 0.0884
    p_value: 0.0118
    q_value: 0.0225
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P17917
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17087725
      assigned_by: UniProt
    - protein: UniProtKB:P17917
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00092661
    - protein: UniProtKB:Q9VIT0
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17087725
      assigned_by: UniProt
    - protein: UniProtKB:Q9VIT0
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00092661
  - go_id: GO:0015783
    label: GDP-fucose transmembrane transport
    aspect: BP
    flagged_taxon: Animals
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 2
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 4
    rate_ratio: 0.0884
    p_value: 0.0118
    q_value: 0.0225
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VHT4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:15530860
      assigned_by: FlyBase
      gene_review: genes/DROME/Gfr/Gfr-ai-review.yaml
    - protein: UniProtKB:Q9VHT4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:16344471
      assigned_by: FlyBase
      gene_review: genes/DROME/Gfr/Gfr-ai-review.yaml
    - protein: UniProtKB:Q9W429
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:19948734
      assigned_by: FlyBase
      gene_review: genes/DROME/Efr/Efr-ai-review.yaml
  - go_id: GO:0015793
    label: glycerol transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 41
      Archaea: 1
      Bacteria: 7
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8VZ80
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015168
    - protein: UniProtKB:Q9SAI4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0015168
  - go_id: GO:0032559
    label: adenyl ribonucleotide binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 19
      Archaea: 0
      Bacteria: 7
      Fungi: 3
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:C7B2E9
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033732
    - protein: UniProtKB:F4IMB5
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033732
  - go_id: GO:0035539
    label: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 28
      Archaea: 0
      Bacteria: 7
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RKB0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00098341
    - protein: UniProtKB:Q9CA40
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001441425|UniProtKB:Q9NV35
    - protein: UniProtKB:Q9CA40
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:3.6.1.55
    - protein: UniProtKB:Q9CA40
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:31575
  - go_id: GO:0052815
    label: medium-chain fatty acyl-CoA hydrolase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 34
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4HU51
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:14660652
      assigned_by: UniProt
    - protein: UniProtKB:Q5FYU1
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:F4HU51
  - go_id: GO:0033818
    label: beta-ketoacyl-acyl-carrier-protein synthase III activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SNT2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001823076|UniProtKB:O34746|UniProtKB:P0A6R0|UniProtKB:P72392|UniProtKB:P9WNG3|UniProtKB:Q9ZBV4
    - protein: UniProtKB:D8SNT2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.1.180|EC:2.3.1.180
    - protein: UniProtKB:D8SNT2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086384
    - protein: UniProtKB:P49243
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001823076|UniProtKB:O34746|UniProtKB:P0A6R0|UniProtKB:P72392|UniProtKB:P9WNG3|UniProtKB:Q9ZBV4
    - protein: UniProtKB:P49243
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.3.1.180
    - protein: UniProtKB:P49243
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12080
    - protein: UniProtKB:P49243
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086384
  - go_id: GO:0008760
    label: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RDE2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000472564|UniProtKB:P0A749
    - protein: UniProtKB:D8RDE2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005750
    - protein: UniProtKB:D8RDE2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.5.1.7|EC:2.5.1.7
    - protein: UniProtKB:D8RSB4
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000472564|UniProtKB:P0A749
    - protein: UniProtKB:D8RSB4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR005750
    - protein: UniProtKB:D8RSB4
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.5.1.7|EC:2.5.1.7
  - go_id: GO:0032267
    label: tRNA(Ile)-lysidine synthase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S1U3
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000211457|UniProtKB:P52097
    - protein: UniProtKB:F4J7P7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000211457|UniProtKB:P52097
  - go_id: GO:0061503
    label: tRNA threonylcarbamoyladenosine dehydratase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 7
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0887
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QP30
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000180394|PANTHER:PTN001333297|SGD:S000001045|SGD:S000001510|UniProtKB:Q46927
    - protein: UniProtKB:D8SIZ6
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000180394|PANTHER:PTN001333297|SGD:S000001045|SGD:S000001510|UniProtKB:Q46927
  - go_id: GO:2001234
    label: negative regulation of apoptotic signaling pathway
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 230
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.089
    p_value: 0.000403
    q_value: 0.00105
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P04807
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:31862471
      assigned_by: SGD
      gene_review: genes/yeast/HXK2/HXK2-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:2001234
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:2001234
  - go_id: GO:0015828
    label: tyrosine transport
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 25
      Archaea: 0
      Bacteria: 1
      Fungi: 10
      Plants: 0
    rate_ratio: 0.089
    p_value: 0.00675
    q_value: 0.0134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15993
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:4919744
      assigned_by: EcoCyc
    - protein: UniProtKB:P15993
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:9150230
      assigned_by: EcoCyc
  - go_id: GO:0097268
    label: cytoophidium
    aspect: CC
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 34
      Archaea: 0
      Bacteria: 1
      Fungi: 10
      Plants: 8
    rate_ratio: 0.089
    p_value: 0.00675
    q_value: 0.0134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A7E5
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:32507415
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0097268
  - go_id: GO:0071218
    label: cellular response to misfolded protein
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 56
      Archaea: 0
      Bacteria: 1
      Fungi: 10
      Plants: 9
    rate_ratio: 0.089
    p_value: 0.00675
    q_value: 0.0134
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AEE3
      taxon: NCBITaxon:83333
      evidence: IMP
      reference: PMID:12679035
      assigned_by: EcoCyc
  - go_id: GO:0008281
    label: sulfonylurea receptor activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 63
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0898
    p_value: 0.000735
    q_value: 0.00181
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7GB25
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:14684837
      assigned_by: TAIR
  - go_id: GO:0045859
    label: regulation of protein kinase activity
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 63
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0898
    p_value: 0.000735
    q_value: 0.00181
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9SCY5
      taxon: NCBITaxon:3702
      evidence: IPI
      reference: PMID:25736509
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G01090
  - go_id: GO:0036449
    label: microtubule minus-end
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 63
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0898
    p_value: 0.000735
    q_value: 0.00181
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IIM1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:22294619
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0036449
  - go_id: GO:0048863
    label: stem cell differentiation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 189
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0898
    p_value: 3.74e-10
    q_value: 2.14e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q07100
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:26792519
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT3G59420
    - protein: UniProtKB:Q07100
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:26792519
      assigned_by: TAIR
    - protein: UniProtKB:Q8L9H6
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:35519820
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT2G01505
    - protein: UniProtKB:Q8S8M2
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:35519820
      assigned_by: TAIR
      with_from: AGI_LocusCode:AT1G70895
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0048863
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0048863
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0048863
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0048863
  - go_id: GO:0045104
    label: intermediate filament cytoskeleton organization
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 227
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0902
    p_value: 0.00046
    q_value: 0.00118
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q03898
      taxon: NCBITaxon:559292
      evidence: IDA
      reference: PMID:12551942
      assigned_by: SGD
  - go_id: GO:0070382
    label: exocytic vesicle
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 125
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0905
    p_value: 5.73e-07
    q_value: 2.31e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JQZ3
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19108776
      assigned_by: TAIR
    - protein: UniProtKB:Q9LH50
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18591430
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070382
  - go_id: GO:0006851
    label: mitochondrial calcium ion transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 187
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0907
    p_value: 5.02e-10
    q_value: 2.83e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RGN7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039800
    - protein: UniProtKB:D8S591
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039800
    - protein: UniProtKB:Q9SZ45
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039800
  - go_id: GO:0071889
    label: 14-3-3 protein binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 225
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.091
    p_value: 0.000502
    q_value: 0.00128
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09838
      taxon: NCBITaxon:284812
      evidence: IPI
      reference: PMID:22496451
      assigned_by: PomBase
      with_from: PomBase:SPAC17A2.13c
    - protein: UniProtKB:Q09838
      taxon: NCBITaxon:284812
      evidence: IPI
      reference: PMID:22496451
      assigned_by: PomBase
      with_from: PomBase:SPAC8E11.02c
  - go_id: GO:0071318
    label: cellular response to ATP
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 62
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0912
    p_value: 0.000853
    q_value: 0.00207
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9LSR8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24436418
      assigned_by: UniProt
  - go_id: GO:0043995
    label: histone H4K5 acetyltransferase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 62
      Archaea: 0
      Bacteria: 0
      Fungi: 3
      Plants: 1
    rate_ratio: 0.0912
    p_value: 0.000853
    q_value: 0.00207
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FLF7
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:23273925
      assigned_by: CACAO
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0043995
  - go_id: GO:0030644
    label: intracellular chloride ion homeostasis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 62
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0912
    p_value: 0.000853
    q_value: 0.00207
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FGT8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24028869
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030644
  - go_id: GO:0006509
    label: membrane protein ectodomain proteolysis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 186
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0912
    p_value: 5.81e-10
    q_value: 3.27e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RGP0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0284421|PANTHER:PTN000024429|RGD:3425|UniProtKB:P49768|UniProtKB:P49810
    - protein: UniProtKB:O64668
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0284421|PANTHER:PTN000024429|RGD:3425|UniProtKB:P49768|UniProtKB:P49810
    - protein: UniProtKB:Q9SIK7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0284421|PANTHER:PTN000024429|RGD:3425|UniProtKB:P49768|UniProtKB:P49810
  - go_id: GO:0097729
    label: 9+2 motile cilium
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 185
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 3
    rate_ratio: 0.0917
    p_value: 6.74e-10
    q_value: 3.75e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8REA1
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0013810|FB:FBgn0013811|FB:FBgn0013813|FB:FBgn0035581|FB:FBgn0267432|FB:FBgn0283476|MGI:MGI:107714|MGI:MGI:107718|MGI:MGI:107720|MGI:MGI:107721|MGI:MGI:1100864|MGI:MGI:1289279|MGI:MGI:1917176|MGI:MGI:1924755|MGI:MGI:2683040|PANTHER:PTN000743491|UniProtKB:F1SC07|UniProtKB:Q8IVF4|UniProtKB:Q8TD57|UniProtKB:Q8TE73|UniProtKB:Q8WXX0|UniProtKB:Q96DT5|UniProtKB:Q96JB1|UniProtKB:Q96M86|UniProtKB:Q9C0G6|UniProtKB:Q9NYC9|UniProtKB:Q9P225|UniProtKB:Q9P2D7|UniProtKB:Q9UFH2
    - protein: UniProtKB:D8STS7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0013810|FB:FBgn0013811|FB:FBgn0013813|FB:FBgn0035581|FB:FBgn0267432|FB:FBgn0283476|MGI:MGI:107714|MGI:MGI:107718|MGI:MGI:107720|MGI:MGI:107721|MGI:MGI:1100864|MGI:MGI:1289279|MGI:MGI:1917176|MGI:MGI:1924755|MGI:MGI:2683040|PANTHER:PTN000743491|UniProtKB:F1SC07|UniProtKB:Q8IVF4|UniProtKB:Q8TD57|UniProtKB:Q8TE73|UniProtKB:Q8WXX0|UniProtKB:Q96DT5|UniProtKB:Q96JB1|UniProtKB:Q96M86|UniProtKB:Q9C0G6|UniProtKB:Q9NYC9|UniProtKB:Q9P225|UniProtKB:Q9P2D7|UniProtKB:Q9UFH2
    - protein: UniProtKB:D8T4D7
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0013810|FB:FBgn0013811|FB:FBgn0013813|FB:FBgn0035581|FB:FBgn0267432|FB:FBgn0283476|MGI:MGI:107714|MGI:MGI:107718|MGI:MGI:107720|MGI:MGI:107721|MGI:MGI:1100864|MGI:MGI:1289279|MGI:MGI:1917176|MGI:MGI:1924755|MGI:MGI:2683040|PANTHER:PTN000743491|UniProtKB:F1SC07|UniProtKB:Q8IVF4|UniProtKB:Q8TD57|UniProtKB:Q8TE73|UniProtKB:Q8WXX0|UniProtKB:Q96DT5|UniProtKB:Q96JB1|UniProtKB:Q96M86|UniProtKB:Q9C0G6|UniProtKB:Q9NYC9|UniProtKB:Q9P225|UniProtKB:Q9P2D7|UniProtKB:Q9UFH2
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0097729
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0097729
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0097729
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0097729
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0097729
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0097729
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0097729
  - go_id: GO:0032787
    label: monocarboxylic acid metabolic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 155
      Archaea: 6
      Bacteria: 3
      Fungi: 10
      Plants: 10
    rate_ratio: 0.092
    p_value: 0.00154
    q_value: 0.00355
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0ADP2
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:35876515
      assigned_by: EcoCyc
    - protein: UniProtKB:P51831
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027288
    - protein: UniProtKB:Q18B45
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027288
  - go_id: GO:0043805
    label: indolepyruvate ferredoxin oxidoreductase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 2
      Fungi: 0
      Plants: 0
    rate_ratio: 0.092
    p_value: 0.0134
    q_value: 0.0252
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q181W5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017721
    - protein: UniProtKB:Q181W5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.7.8|EC:1.2.7.8
    - protein: UniProtKB:Q181W5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000126471|UniRule:UR001995777
    - protein: UniProtKB:Q181W5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12645
    - protein: UniProtKB:Q181W6
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.7.8|EC:1.2.7.8
  - go_id: GO:0015667
    label: site-specific DNA-methyltransferase (cytosine-N4-specific) activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Archaea
    annotated_protein_counts:
      Animals: 0
      Archaea: 4
      Bacteria: 2
      Fungi: 0
      Plants: 0
    rate_ratio: 0.092
    p_value: 0.0134
    q_value: 0.0252
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O25921
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017985
    - protein: UniProtKB:O25921
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.113|EC:2.1.1.113
    - protein: UniProtKB:O25921
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:16857
    - protein: UniProtKB:Q18AW5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR017985
    - protein: UniProtKB:Q18AW5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.1.1.113|EC:2.1.1.113
    - protein: UniProtKB:Q18AW5
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:16857
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0015667
  - go_id: GO:0010039
    label: response to iron ion
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 53
      Archaea: 0
      Bacteria: 1
      Fungi: 0
      Plants: 35
    rate_ratio: 0.0921
    p_value: 0.00145
    q_value: 0.00335
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15028
      taxon: NCBITaxon:83333
      evidence: IEP
      reference: PMID:6376472
      assigned_by: EcoCyc
  - go_id: GO:0051180
    label: vitamin transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 107
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RLU9
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002666
    - protein: UniProtKB:D8RNC5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002666
  - go_id: GO:0017177
    label: glucosidase II complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 51
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FM96
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107877|PANTHER:PTN000290448|SGD:S000002629|UniProtKB:P14314
    - protein: UniProtKB:Q9SLC0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107877|PANTHER:PTN000290448|SGD:S000002629|UniProtKB:P14314
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0017177
  - go_id: GO:0033557
    label: Slx1-Slx4 complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 21
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QRY0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0037263|PANTHER:PTN000463591|SGD:S000000432|UniProtKB:Q9BQ83|WB:WBGene00018909
    - protein: UniProtKB:F4IMS6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR027520
    - protein: UniProtKB:F4IMS6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000106239
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0033557
  - go_id: GO:0033565
    label: ESCRT-0 complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 39
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8REJ0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002493178|PomBase:SPAC19A8.05c|SGD:S000005289
    - protein: UniProtKB:D8RI30
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002493178|PomBase:SPAC19A8.05c|SGD:S000005289
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0033565
  - go_id: GO:0006550
    label: L-isoleucine catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 61
      Archaea: 0
      Bacteria: 2
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QMK2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0030482|MGI:MGI:104861|MGI:MGI:1276534|PANTHER:PTN000214535|RGD:68948|WB:WBGene00001149
    - protein: UniProtKB:D8R7M9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0030482|MGI:MGI:104861|MGI:MGI:1276534|PANTHER:PTN000214535|RGD:68948|WB:WBGene00001149
  - go_id: GO:0000388
    label: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 39
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O48534
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002375518|SGD:S000000974|UniProtKB:O75643
    - protein: UniProtKB:Q9SYP1
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN002375518|SGD:S000000974|UniProtKB:O75643
  - go_id: GO:0098800
    label: inner mitochondrial membrane protein complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 15
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8LAJ9
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26898467
      assigned_by: UniProt
    - protein: UniProtKB:Q9ASV5
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:26898467
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0098800
  - go_id: GO:0071475
    label: cellular hyperosmotic salinity response
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 22
      Archaea: 0
      Bacteria: 2
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JUU5
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:20876872
      assigned_by: UniProt
    - protein: UniProtKB:Q9SYK9
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:20798329
      assigned_by: TAIR
  - go_id: GO:0034462
    label: small-subunit processome assembly
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 15
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R652
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000267771|SGD:S000005337
    - protein: UniProtKB:D8SGB9
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000267771|SGD:S000005337
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0034462
  - go_id: GO:0008160
    label: protein tyrosine phosphatase activator activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 32
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SYB5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000000630|UniProtKB:Q15257
    - protein: UniProtKB:D8T749
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000000630|UniProtKB:Q15257
  - go_id: GO:1990529
    label: glycosylphosphatidylinositol-mannosyltransferase I complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 15
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RC64
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000306537|RGD:71041|SGD:S000003774
    - protein: UniProtKB:Q500W7
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000306537|RGD:71041|SGD:S000003774
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990529
  - go_id: GO:0098721
    label: uracil import across plasma membrane
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 4
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3E7D0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G27810|PANTHER:PTN001671589
    - protein: UniProtKB:Q3E7D0
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25135661
      assigned_by: TAIR
    - protein: UniProtKB:Q8GZD4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G26510|PANTHER:PTN000122388
    - protein: UniProtKB:Q8GZD4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:25135661
      assigned_by: TAIR
  - go_id: GO:0043144
    label: sno(s)RNA processing
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 0
      Fungi: 6
      Plants: 2
    rate_ratio: 0.0921
    p_value: 0.00383
    q_value: 0.00813
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4JKB6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084307
    - protein: UniProtKB:F4JKB6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22549728
      assigned_by: TAIR
    - protein: UniProtKB:F4JKB6
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22549728
      assigned_by: UniProt
    - protein: UniProtKB:Q680B9
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084307
      gene_review: genes/ARATH/PRORP2/PRORP2-ai-review.yaml
    - protein: UniProtKB:Q680B9
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:22549728
      assigned_by: TAIR
      gene_review: genes/ARATH/PRORP2/PRORP2-ai-review.yaml
  - go_id: GO:0071528
    label: tRNA re-export from nucleus
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 90
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 3
    rate_ratio: 0.0921
    p_value: 0.00024
    q_value: 0.000655
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RVE5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409486|SGD:S000001688
    - protein: UniProtKB:D8RVE5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR040017
    - protein: UniProtKB:D8RVE5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001184764
    - protein: UniProtKB:D8S245
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409486|SGD:S000001688
    - protein: UniProtKB:D8S245
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR040017
    - protein: UniProtKB:D8S245
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001184764
    - protein: UniProtKB:Q7PC79
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000409486|SGD:S000001688
    - protein: UniProtKB:Q7PC79
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR040017
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0071528
  - go_id: GO:0071027
    label: nuclear RNA surveillance
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 31
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 3
    rate_ratio: 0.0921
    p_value: 0.00024
    q_value: 0.000655
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8SCD7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027040
    - protein: UniProtKB:D8SGL5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027040
    - protein: UniProtKB:Q9SP08
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027040
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071027
  - go_id: GO:0070860
    label: RNA polymerase I core factor complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 17
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 3
    rate_ratio: 0.0921
    p_value: 0.00024
    q_value: 0.000655
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1P8AW93
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033599
    - protein: UniProtKB:D8SEQ9
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033599
    - protein: UniProtKB:Q5XVF0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001586581|SGD:S000003562|UniProtKB:Q53T94
    - protein: UniProtKB:Q5XVF0
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR033599
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0070860
  - go_id: GO:0044853
    label: plasma membrane raft
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 174
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 3
    rate_ratio: 0.0921
    p_value: 0.00024
    q_value: 0.000655
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4V3D6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G25250|AGI_LocusCode:AT5G25260|AGI_LocusCode:AT5G64870|PANTHER:PTN001013447
    - protein: UniProtKB:Q4V3D6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31610051
      assigned_by: TAIR
    - protein: UniProtKB:Q4V3D6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026453
    - protein: UniProtKB:Q501E6
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G25250|AGI_LocusCode:AT5G25260|AGI_LocusCode:AT5G64870|PANTHER:PTN001013447
    - protein: UniProtKB:Q501E6
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31610051
      assigned_by: TAIR
    - protein: UniProtKB:Q501E6
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026453
    - protein: UniProtKB:Q9LV90
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT5G25250|AGI_LocusCode:AT5G25260|AGI_LocusCode:AT5G64870|PANTHER:PTN001013447
    - protein: UniProtKB:Q9LV90
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:31610051
      assigned_by: TAIR
    - protein: UniProtKB:Q9LV90
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026453
  - go_id: GO:0051306
    label: mitotic sister chromatid separation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 34
      Archaea: 0
      Bacteria: 0
      Fungi: 9
      Plants: 3
    rate_ratio: 0.0921
    p_value: 0.00024
    q_value: 0.000655
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QR20
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1289164|PANTHER:PTN001285342
    - protein: UniProtKB:D8R7W5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1289164|PANTHER:PTN001285342
    - protein: UniProtKB:Q9LUR0
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1289164|PANTHER:PTN001285342
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051306
  - go_id: GO:0005221
    label: intracellularly cyclic nucleotide-activated monoatomic cation channel activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 61
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0927
    p_value: 0.000989
    q_value: 0.00236
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O65718
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:10900264
      assigned_by: TAIR
  - go_id: GO:0019855
    label: calcium channel inhibitor activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 61
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0927
    p_value: 0.000989
    q_value: 0.00236
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O22227
      taxon: NCBITaxon:3702
      evidence: IGI
      reference: PMID:39405435
      assigned_by: TAIR
      with_from: SGD:S000001673,SGD:S000002286,SGD:S000002974
  - go_id: GO:0004777
    label: succinate-semialdehyde dehydrogenase (NAD+) activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 21
      Archaea: 1
      Bacteria: 10
      Fungi: 6
      Plants: 3
    rate_ratio: 0.0931
    p_value: 0.000154
    q_value: 0.000434
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G79440|FB:FBgn0039349|MGI:MGI:2441982|PANTHER:PTN008681047|RGD:621422|SGD:S000000210|UniProtKB:P25526|UniProtKB:P51649
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.1.24|EC:1.2.1.24
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001051784
    - protein: UniProtKB:D8QTT0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13217
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G79440|FB:FBgn0039349|MGI:MGI:2441982|PANTHER:PTN008681047|RGD:621422|SGD:S000000210|UniProtKB:P25526|UniProtKB:P51649
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.1.24|EC:1.2.1.24
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR001051784
    - protein: UniProtKB:D8RJV5
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13217
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT1G79440|FB:FBgn0039349|MGI:MGI:2441982|PANTHER:PTN008681047|RGD:621422|SGD:S000000210|UniProtKB:P25526|UniProtKB:P51649
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:10517851
      assigned_by: TAIR
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.2.1.24
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:13217
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: ISA
      reference: PMID:10517851
      assigned_by: CACAO
      with_from: UniProtKB:P51649
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: ISA
      reference: PMID:10517851
      assigned_by: CACAO
      with_from: UniProtKB:P51650
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: ISA
      reference: PMID:10517851
      assigned_by: CACAO
      with_from: UniProtKB:P76149
    - protein: UniProtKB:Q9SAK4
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:10517851
      assigned_by: TAIR
  - go_id: GO:0015757
    label: galactose transmembrane transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 27
      Archaea: 0
      Bacteria: 10
      Fungi: 8
      Plants: 3
    rate_ratio: 0.0931
    p_value: 0.000154
    q_value: 0.000434
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8GW61
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005354
    - protein: UniProtKB:Q8VZ80
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005354
    - protein: UniProtKB:Q9LT15
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005354
  - go_id: GO:0019572
    label: L-arabinose catabolic process
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 12
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0936
    p_value: 0.0064
    q_value: 0.0128
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q07993
      taxon: NCBITaxon:559292
      evidence: IEA
      reference: GO_REF:0000041
      assigned_by: UniProt
      with_from: UniProtKB-UniPathway:UPA00146
      gene_review: genes/yeast/XYL2/XYL2-ai-review.yaml
  - go_id: GO:0032482
    label: Rab protein signal transduction
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 120
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0943
    p_value: 1.2e-06
    q_value: 4.61e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QUM7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR041833
    - protein: UniProtKB:D8T1E0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR041833
  - go_id: GO:0006884
    label: cell volume homeostasis
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 120
      Archaea: 0
      Bacteria: 3
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0943
    p_value: 1.2e-06
    q_value: 4.61e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8R326
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003521
    - protein: UniProtKB:Q9LVA7
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003521
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006884
  - go_id: GO:0050708
    label: regulation of protein secretion
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 60
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 1
    rate_ratio: 0.0943
    p_value: 0.00115
    q_value: 0.0027
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FK28
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:21549312
      assigned_by: TAIR
  - go_id: GO:0033234
    label: negative regulation of protein sumoylation
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 60
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 1
    rate_ratio: 0.0943
    p_value: 0.00115
    q_value: 0.0027
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A4GSN8
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:17513499
      assigned_by: TAIR
  - go_id: GO:0043325
    label: phosphatidylinositol-3,4-bisphosphate binding
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 178
      Archaea: 0
      Bacteria: 0
      Fungi: 5
      Plants: 3
    rate_ratio: 0.0953
    p_value: 1.88e-09
    q_value: 1.01e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QYV2
      taxon: NCBITaxon:88036
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1928144|PANTHER:PTN008555303|UniProtKB:Q9HB19|UniProtKB:Q9HB21|UniProtKB:Q9UN19|dictyBase:DDB_G0285161
    - protein: UniProtKB:Q8VWF1
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:28584166
      assigned_by: UniProt
    - protein: UniProtKB:Q96262
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:18397324
      assigned_by: UniProt
  - go_id: GO:0008143
    label: poly(A) binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 301
      Archaea: 5
      Bacteria: 3
      Fungi: 28
      Plants: 37
    rate_ratio: 0.0954
    p_value: 1.02e-06
    q_value: 3.95e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0A972
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:11390393
      assigned_by: EcoCyc
    - protein: UniProtKB:P0ABF1
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:35652235
      assigned_by: EcoCyc
    - protein: UniProtKB:P21507
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:2461520
      assigned_by: UniProt
  - go_id: GO:0015931
    label: nucleobase-containing compound transport
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 118
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0959
    p_value: 1.61e-06
    q_value: 6.07e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8RD67
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005338
    - protein: UniProtKB:D8RFA2
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000108
      assigned_by: GOC
      with_from: GO:0005338
  - go_id: GO:0015075
    label: monoatomic ion transmembrane transporter activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 175
      Archaea: 1
      Bacteria: 3
      Fungi: 3
      Plants: 3
    rate_ratio: 0.097
    p_value: 2.93e-09
    q_value: 1.53e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8QQK0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004686
    - protein: UniProtKB:D8R8D0
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004686
    - protein: UniProtKB:Q94A76
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:24517091
      assigned_by: TAIR
  - go_id: GO:0071005
    label: U2-type precatalytic spliceosome
    aspect: CC
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 211
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.097
    p_value: 0.000923
    q_value: 0.00222
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O60138
      taxon: NCBITaxon:284812
      evidence: ISO
      reference: GO_REF:0000024
      assigned_by: PomBase
      with_from: UniProtKB:O75554
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071005
  - go_id: GO:0051291
    label: protein heterooligomerization
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 116
      Archaea: 0
      Bacteria: 1
      Fungi: 2
      Plants: 2
    rate_ratio: 0.0975
    p_value: 2.16e-06
    q_value: 8.01e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9FF75
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19807882
      assigned_by: UniProt
      gene_review: genes/ARATH/SUN1/SUN1-ai-review.yaml
    - protein: UniProtKB:Q9FF75
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089325
      gene_review: genes/ARATH/SUN1/SUN1-ai-review.yaml
    - protein: UniProtKB:Q9SG79
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:19807882
      assigned_by: UniProt
      gene_review: genes/ARATH/SUN2/SUN2-ai-review.yaml
    - protein: UniProtKB:Q9SG79
      taxon: NCBITaxon:3702
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089325
      gene_review: genes/ARATH/SUN2/SUN2-ai-review.yaml
  - go_id: GO:0016104
    label: triterpenoid biosynthetic process
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 23
      Archaea: 0
      Bacteria: 1
      Fungi: 3
      Plants: 33
    rate_ratio: 0.0976
    p_value: 0.00236
    q_value: 0.00524
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q796C3
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR018333
  - go_id: GO:0007059
    label: chromosome segregation
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 481
      Archaea: 2
      Bacteria: 77
      Fungi: 99
      Plants: 44
    rate_ratio: 0.0977
    p_value: 2.73e-06
    q_value: 1.0e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q6LXF4
      taxon: NCBITaxon:267377
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000087083
    - protein: UniProtKB:Q9HK21
      taxon: NCBITaxon:273075
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000087083
  - go_id: GO:0015485
    label: cholesterol binding
    aspect: MF
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 418
      Archaea: 0
      Bacteria: 0
      Fungi: 2
      Plants: 0
    rate_ratio: 0.0979
    p_value: 9.25e-07
    q_value: 3.62e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q59ZX3
      taxon: NCBITaxon:237561
      evidence: IDA
      reference: PMID:30080909
      assigned_by: CGD
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0015485
    - protein: UniProtKB:Q5AB48
      taxon: NCBITaxon:237561
      evidence: IDA
      reference: PMID:30080909
      assigned_by: CGD
      violates_go_taxon_constraint:
      - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0015485
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0015485
  - go_id: GO:0004712
    label: protein serine/threonine/tyrosine kinase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Plants
    annotated_protein_counts:
      Animals: 242
      Archaea: 2
      Bacteria: 3
      Fungi: 18
      Plants: 98
    rate_ratio: 0.0986
    p_value: 1.53e-08
    q_value: 7.39e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O34483
      taxon: NCBITaxon:224308
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000101441
    - protein: UniProtKB:P47331
      taxon: NCBITaxon:243273
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000101441
    - protein: UniProtKB:Q180Q7
      taxon: NCBITaxon:272563
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000101441
  - go_id: GO:0007030
    label: Golgi organization
    aspect: BP
    flagged_taxon: Archaea
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 851
      Archaea: 1
      Bacteria: 0
      Fungi: 49
      Plants: 62
    rate_ratio: 0.0987
    p_value: 0.00189
    q_value: 0.00426
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q4J6E6
      taxon: NCBITaxon:330779
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000432562
  - go_id: GO:0050709
    label: negative regulation of protein secretion
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 207
      Archaea: 0
      Bacteria: 2
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0989
    p_value: 0.0011
    q_value: 0.00259
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PES5
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:40484102
      assigned_by: CGD
  - go_id: GO:0034394
    label: protein localization to cell surface
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 207
      Archaea: 0
      Bacteria: 0
      Fungi: 1
      Plants: 0
    rate_ratio: 0.0989
    p_value: 0.0011
    q_value: 0.00259
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q04697
      taxon: NCBITaxon:559292
      evidence: IGI
      reference: PMID:10377429
      assigned_by: SGD
      with_from: SGD:S000001136
      gene_review: genes/yeast/GSF2/GSF2-ai-review.yaml
    - protein: UniProtKB:Q04697
      taxon: NCBITaxon:559292
      evidence: IMP
      reference: PMID:10377429
      assigned_by: SGD
      gene_review: genes/yeast/GSF2/GSF2-ai-review.yaml
  - go_id: GO:0004620
    label: glycerophospholipase activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 251
      Archaea: 0
      Bacteria: 3
      Fungi: 27
      Plants: 41
    rate_ratio: 0.0989
    p_value: 1.96e-06
    q_value: 7.33e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O25241
      taxon: NCBITaxon:85962
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003187|InterPro:IPR036541
    - protein: UniProtKB:P0A231
      taxon: NCBITaxon:99287
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003187|InterPro:IPR036541
    - protein: UniProtKB:P0A921
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:2653433
      assigned_by: EcoCyc
    - protein: UniProtKB:P0A921
      taxon: NCBITaxon:83333
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR003187|InterPro:IPR036541
  - go_id: GO:0015204
    label: urea transmembrane transporter activity
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 39
      Archaea: 0
      Bacteria: 1
      Fungi: 9
      Plants: 7
    rate_ratio: 0.0989
    p_value: 0.0131
    q_value: 0.0247
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z8K5
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004937
    - protein: UniProtKB:A0A0H2Z8K5
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027786
  - go_id: GO:0071918
    label: urea transmembrane transport
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 50
      Archaea: 0
      Bacteria: 1
      Fungi: 9
      Plants: 7
    rate_ratio: 0.0989
    p_value: 0.0131
    q_value: 0.0247
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z8K5
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR004937
  - go_id: GO:0030007
    label: intracellular potassium ion homeostasis
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 135
      Archaea: 1
      Bacteria: 2
      Fungi: 18
      Plants: 7
    rate_ratio: 0.0989
    p_value: 0.000152
    q_value: 0.000428
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P65524
      taxon: NCBITaxon:99287
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000197900|PANTHER:PTN009136753
    - protein: UniProtKB:P76007
      taxon: NCBITaxon:83333
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: CGD:CAL0000197900|PANTHER:PTN009136753
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030007
  - go_id: GO:0019367
    label: fatty acid elongation, saturated fatty acid
    aspect: BP
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 66
      Archaea: 0
      Bacteria: 1
      Fungi: 9
      Plants: 8
    rate_ratio: 0.0989
    p_value: 0.0131
    q_value: 0.0247
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P0AAI5
      taxon: NCBITaxon:83333
      evidence: IDA
      reference: PMID:9013860
      assigned_by: EcoCyc
  - go_id: GO:0034513
    label: box H/ACA snoRNA binding
    aspect: MF
    flagged_taxon: Bacteria
    highest_taxon: Fungi
    annotated_protein_counts:
      Animals: 26
      Archaea: 0
      Bacteria: 1
      Fungi: 9
      Plants: 6
    rate_ratio: 0.0989
    p_value: 0.0131
    q_value: 0.0247
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0H2Z8D5
      taxon: NCBITaxon:208963
      evidence: IEA
      reference: GO_REF:0000118
      assigned_by: TreeGrafter
      with_from: PANTHER:PTN000579935
  - go_id: GO:1900190
    label: regulation of single-species biofilm formation
    aspect: BP
    flagged_taxon: Fungi
    highest_taxon: Bacteria
    annotated_protein_counts:
      Animals: 0
      Archaea: 0
      Bacteria: 34
      Fungi: 3
      Plants: 0
    rate_ratio: 0.0991
    p_value: 7.11e-07
    q_value: 2.82e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D8PKB4
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:29107946
      assigned_by: CGD
    - protein: UniProtKB:A0A1D8PLL1
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:36855815
      assigned_by: CGD
    - protein: UniProtKB:A0A1D8PNS7
      taxon: NCBITaxon:237561
      evidence: IMP
      reference: PMID:36855815
      assigned_by: CGD
  - go_id: GO:0052651
    label: monoacylglycerol catabolic process
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 57
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0992
    p_value: 0.00178
    q_value: 0.00405
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O49523
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT4G18550|PANTHER:PTN004887113
    - protein: UniProtKB:O49523
      taxon: NCBITaxon:3702
      evidence: IDA
      reference: PMID:21477884
      assigned_by: TAIR
  - go_id: GO:0000783
    label: nuclear telomere cap complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 114
      Archaea: 0
      Bacteria: 0
      Fungi: 4
      Plants: 2
    rate_ratio: 0.0992
    p_value: 2.89e-06
    q_value: 1.05e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q56Y52
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1920086|MGI:MGI:2141503|PANTHER:PTN000376531|SGD:S000002379|UniProtKB:Q9NUX5
    - protein: UniProtKB:Q6NKX5
      taxon: NCBITaxon:3702
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1920086|MGI:MGI:2141503|PANTHER:PTN000376531|SGD:S000002379|UniProtKB:Q9NUX5
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000783
  - go_id: GO:0042246
    label: tissue regeneration
    aspect: BP
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 114
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 2
    rate_ratio: 0.0992
    p_value: 2.89e-06
    q_value: 1.05e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8L5Z1
      taxon: NCBITaxon:3702
      evidence: IEP
      reference: PMID:35605192
      assigned_by: TAIR
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0042246
    - protein: UniProtKB:Q8W485
      taxon: NCBITaxon:3702
      evidence: IMP
      reference: PMID:28724620
      assigned_by: TAIR
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0042246
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0042246
  - go_id: GO:0004466
    label: long-chain fatty acyl-CoA dehydrogenase activity
    aspect: MF
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 114
      Archaea: 0
      Bacteria: 5
      Fungi: 1
      Plants: 2
    rate_ratio: 0.0992
    p_value: 2.89e-06
    q_value: 1.05e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D8S3D8
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.3.8.8|EC:1.3.8.8
    - protein: UniProtKB:D8S7U7
      taxon: NCBITaxon:88036
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:1.3.8.8|EC:1.3.8.8
  - go_id: GO:0016461
    label: unconventional myosin complex
    aspect: CC
    flagged_taxon: Plants
    highest_taxon: Animals
    annotated_protein_counts:
      Animals: 57
      Archaea: 0
      Bacteria: 0
      Fungi: 0
      Plants: 1
    rate_ratio: 0.0992
    p_value: 0.00178
    q_value: 0.00405
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F4IRU3
      taxon: NCBITaxon:3702
      evidence: ISS
      reference: PMID:7811972
      assigned_by: TAIR
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0016461
  dropped:
    root_terms: 3
    root_term_flagged_annotations: 14456
    root_term_flagged_nd_annotations: 14456
    terms_over_max_flagged: 1371
  significant_terms: 2615
  candidate_terms: 1241
phylum:
  level: phylum
  groups:
  - Vertebrates
  - Invertebrates
  annotated_proteins_per_group:
    Vertebrates: 315432
    Invertebrates: 35604
  terms_with_rate_ratio: 8613
  flagged_terms: 577
  terms:
  - go_id: GO:0005700
    label: polytene chromosome
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 151
    rate_ratio: 0.00224
    p_value: 7.36e-145
    q_value: 3.96e-142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZUS5
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0011474|PANTHER:PTN002920257
    - protein: UniProtKB:Q2YDW7
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0011474|PANTHER:PTN002920257
    - protein: UniProtKB:Q9NQR1
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0011474|PANTHER:PTN002920257
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0005700
  - go_id: GO:0045167
    label: asymmetric protein localization involved in cell fate determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 46
    rate_ratio: 0.00245
    p_value: 1.62e-44
    q_value: 1.34e-42
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P24383
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:19497282
      assigned_by: MGI
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045167
  - go_id: GO:0007400
    label: neuroblast fate determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 33
    rate_ratio: 0.00342
    p_value: 9.78e-32
    q_value: 5.43e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q02067
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:11032813
      assigned_by: MGI
      with_from: MGI:MGI:1857470
    - protein: UniProtKB:Q02067
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:12397111
      assigned_by: MGI
      with_from: MGI:MGI:1857470
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0007400
  - go_id: GO:0016360
    label: sensory organ precursor cell fate determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 31
    rate_ratio: 0.00364
    p_value: 8.95e-30
    q_value: 4.51e-28
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P48430
      taxon: NCBITaxon:9031
      evidence: IMP
      reference: PMID:23071561
      assigned_by: AgBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0016360
  - go_id: GO:0008049
    label: male courtship behavior
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 87
    rate_ratio: 0.00389
    p_value: 5.86e-82
    q_value: 1.4e-79
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B0F2B4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18227507
      assigned_by: BHF-UCL
    - protein: UniProtKB:P19091
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2147
      gene_review: genes/mouse/Ar/Ar-ai-review.yaml
    - protein: UniProtKB:P20060
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:12617783
      assigned_by: MGI
      with_from: MGI:MGI:2429701
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0008049
  - go_id: GO:0045886
    label: negative regulation of synaptic assembly at neuromuscular junction
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 75
    rate_ratio: 0.00451
    p_value: 3.21e-70
    q_value: 5.75e-68
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A338P6P8
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:70982
    - protein: UniProtKB:E9QAQ5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:70982
    - protein: UniProtKB:Q9WV60
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:70982
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0045886
  - go_id: GO:0009593
    label: detection of chemical stimulus
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 48
    rate_ratio: 0.0047
    p_value: 3.92e-45
    q_value: 3.38e-43
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A2I3BRZ1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:11498051
      assigned_by: MGI
      with_from: MGI:MGI:2182636
    - protein: UniProtKB:Q8BYH0
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:11498051
      assigned_by: MGI
      with_from: MGI:MGI:2182636
  - go_id: GO:0010171
    label: body morphogenesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 48
    rate_ratio: 0.0047
    p_value: 3.92e-45
    q_value: 3.38e-43
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B1ATR5
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18477453
      assigned_by: MGI
      with_from: MGI:MGI:2159356
    - protein: UniProtKB:Q8CFZ4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:18477453
      assigned_by: MGI
      with_from: MGI:MGI:2159356
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0010171
  - go_id: GO:0035262
    label: gonad morphogenesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 51
    rate_ratio: 0.00664
    p_value: 7.46e-47
    q_value: 6.76e-45
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0A6YY42
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10706291
      assigned_by: MGI
      with_from: MGI:MGI:1888554
    - protein: UniProtKB:P43406
      taxon: NCBITaxon:10090
      evidence: NAS
      reference: PMID:16571912
      assigned_by: BHF-UCL
    - protein: UniProtKB:Q9WUH2
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10706291
      assigned_by: MGI
      with_from: MGI:MGI:1888554
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0035262
  - go_id: GO:0007112
    label: male meiosis cytokinesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 32
    rate_ratio: 0.00705
    p_value: 1.43e-29
    q_value: 7.14e-28
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3TTP0
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0032848|PANTHER:PTN000380100
    - protein: UniProtKB:Q9BZQ2
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0032848|PANTHER:PTN000380100
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0007112
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007112
  - go_id: GO:0048047
    label: mating behavior, sex discrimination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 15
    rate_ratio: 0.00752
    p_value: 3.58e-14
    q_value: 7.54e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9R244
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:11823606
      assigned_by: MGI
      with_from: MGI:MGI:2657154
    - protein: UniProtKB:Q9R244
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:11972034
      assigned_by: MGI
      with_from: MGI:MGI:2179812
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0048047
  - go_id: GO:0030421
    label: defecation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 42
    rate_ratio: 0.00806
    p_value: 3.76e-38
    q_value: 2.61e-36
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P12025
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10096022
      assigned_by: DFLAT
    - protein: UniProtKB:P21741
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P12025|ensembl:ENSMUSP00000068413
    - protein: UniProtKB:Q9Z0M5
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25147230
      assigned_by: MGI
      with_from: MGI:MGI:2451080
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0030421
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0030421
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0030421
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0030421
  - go_id: GO:0000916
    label: actomyosin contractile ring contraction
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 14
    rate_ratio: 0.00806
    p_value: 3.31e-13
    q_value: 6.37e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9UN37
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:28242692
      assigned_by: ARUK-UCL
      gene_review: genes/human/VPS4A/VPS4A-ai-review.yaml
  - go_id: GO:0016998
    label: cell wall macromolecule catabolic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 14
    rate_ratio: 0.00806
    p_value: 3.31e-13
    q_value: 6.37e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P00698
      taxon: NCBITaxon:9031
      evidence: IDA
      reference: PMID:5440837
      assigned_by: CAFA
    - protein: UniProtKB:P00698
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027833
  - go_id: GO:0006963
    label: positive regulation of antibacterial peptide biosynthetic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 26
    rate_ratio: 0.00868
    p_value: 8.89e-24
    q_value: 3.51e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F7DDR4
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:18167348
      assigned_by: MGI
    - protein: UniProtKB:Q8K3Z0
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:18167348
      assigned_by: MGI
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0006963
  - go_id: GO:0007344
    label: pronuclear fusion
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 12
    rate_ratio: 0.00941
    p_value: 2.79e-11
    q_value: 4.48e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P06493
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:21535261
      assigned_by: UniProt
      gene_review: genes/human/CDK1/CDK1-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:58024 (Spermatophyta), on GO:0007344
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007344
  - go_id: GO:0035041
    label: sperm DNA decondensation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 12
    rate_ratio: 0.00941
    p_value: 2.79e-11
    q_value: 4.48e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09430
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:12743712
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0035041
  - go_id: GO:1902884
    label: positive regulation of response to oxidative stress
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 36
    rate_ratio: 0.00941
    p_value: 2.23e-32
    q_value: 1.28e-30
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D3Z2R5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NZV5|ensembl:ENSP00000363434
    - protein: UniProtKB:D3Z2R5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NZV5
    - protein: UniProtKB:D3Z2R5
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9NZV5
    - protein: UniProtKB:Q9NZV5
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:19557870
      assigned_by: UniProt
    - protein: UniProtKB:Q9QZQ8
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:O75367
  - go_id: GO:0072375
    label: medium-term memory
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 23
    rate_ratio: 0.00982
    p_value: 6.77e-21
    q_value: 2.3e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P01100
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P12841|ensembl:ENSRNOP00000010712
    - protein: UniProtKB:P01101
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P12841|ensembl:ENSRNOP00000010712
    - protein: UniProtKB:P01101
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2626
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0072375
  - go_id: GO:0140591
    label: nuclear envelope budding
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 11
    rate_ratio: 0.0103
    p_value: 2.54e-10
    q_value: 3.66e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q2M389
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q9VXH9
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0140591
  - go_id: GO:0035150
    label: regulation of tube size
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 11
    rate_ratio: 0.0103
    p_value: 2.54e-10
    q_value: 3.66e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O35468
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19543268
      assigned_by: MGI
      with_from: MGI:MGI:3526437
    - protein: UniProtKB:O35468
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19543268
      assigned_by: MGI
      with_from: MGI:MGI:3805020
  - go_id: GO:0046660
    label: female sex differentiation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 11
    rate_ratio: 0.0103
    p_value: 2.54e-10
    q_value: 3.66e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9I870
      taxon: NCBITaxon:9031
      evidence: IMP
      reference: PMID:11029061
      assigned_by: AgBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0046660
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0046660
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0046660
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0046660
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0046660
  - go_id: GO:0043062
    label: extracellular structure organization
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 10
    rate_ratio: 0.0113
    p_value: 2.3e-09
    q_value: 2.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P36897
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9759503
      assigned_by: UniProt
  - go_id: GO:0036093
    label: germ cell proliferation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 20
    rate_ratio: 0.0113
    p_value: 5.0e-18
    q_value: 1.45e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0G2JFW4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:23154982
      assigned_by: MGI
      with_from: MGI:MGI:5463352
    - protein: UniProtKB:Q05CL8
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:23154982
      assigned_by: MGI
      with_from: MGI:MGI:5463352
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0036093
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0036093
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0036093
  - go_id: GO:0019101
    label: female somatic sex determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 10
    rate_ratio: 0.0113
    p_value: 2.3e-09
    q_value: 2.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O88470
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:15944199
      assigned_by: MGI
      with_from: MGI:MGI:2182312
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0019101
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0019101
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0019101
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0019101
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0019101
  - go_id: GO:0090278
    label: negative regulation of peptide hormone secretion
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 9
    rate_ratio: 0.0125
    p_value: 2.06e-08
    q_value: 2.32e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P37238
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:11387233
      assigned_by: BHF-UCL
  - go_id: GO:0098595
    label: perivitelline space
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 26
    rate_ratio: 0.013
    p_value: 7.76e-23
    q_value: 2.87e-21
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E9Q099
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:19808884
      assigned_by: MGI
    - protein: UniProtKB:Q12889
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q62010|ensembl:ENSMUSP00000000573
    - protein: UniProtKB:Q62010
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:19808884
      assigned_by: MGI
  - go_id: GO:0000022
    label: mitotic spindle elongation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 17
    rate_ratio: 0.0133
    p_value: 3.56e-15
    q_value: 8.3e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O43663
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9885575
      assigned_by: PINC
    - protein: UniProtKB:Q02241
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:1406973
      assigned_by: PINC
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000022
  - go_id: GO:0004690
    label: cyclic nucleotide-dependent protein kinase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 16
    rate_ratio: 0.0141
    p_value: 3.14e-14
    q_value: 6.65e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A7I2V4H3
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027143
    - protein: UniProtKB:K7ELZ5
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00027143
  - go_id: GO:0070775
    label: H3 histone acetyltransferase complex
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 8
    rate_ratio: 0.0141
    p_value: 1.83e-07
    q_value: 1.83e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A9L9PXM0
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084418
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0070775
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0070775
  - go_id: GO:0030730
    label: triglyceride storage
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 8
    rate_ratio: 0.0141
    p_value: 1.83e-07
    q_value: 1.83e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P59266
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:24519944
      assigned_by: MGI
      with_from: MGI:MGI:2386686,MGI:MGI:5621176
  - go_id: GO:0090389
    label: phagosome-lysosome fusion involved in apoptotic cell clearance
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 8
    rate_ratio: 0.0141
    p_value: 1.83e-07
    q_value: 1.83e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3UHA3
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:26284655
      assigned_by: MGI
      with_from: MGI:MGI:4377985
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0090389
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0090389
  - go_id: GO:1904811
    label: positive regulation of dense core granule transport
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 8
    rate_ratio: 0.0141
    p_value: 1.83e-07
    q_value: 1.83e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8K0G5
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: PMID:27191843
      assigned_by: UniProt
      with_from: UniProtKB:Q9U1Q0
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1904811
  - go_id: GO:0010877
    label: lipid transport involved in lipid storage
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 14
    rate_ratio: 0.0161
    p_value: 2.4e-12
    q_value: 4.29e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P02649
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P08226|ensembl:ENSMUSP00000133302
      gene_review: genes/human/APOE/APOE-ai-review.yaml
    - protein: UniProtKB:P02649
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:P08226
      gene_review: genes/human/APOE/APOE-ai-review.yaml
    - protein: UniProtKB:P08226
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:23741427
      assigned_by: BHF-UCL
  - go_id: GO:2001262
    label: positive regulation of semaphorin-plexin signaling pathway
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 21
    rate_ratio: 0.0161
    p_value: 4.02e-18
    q_value: 1.16e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XEZ9
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q61039|ensembl:ENSMUSP00000044983
    - protein: UniProtKB:P61296
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q61039|ensembl:ENSMUSP00000044983
      gene_review: genes/human/HAND2/HAND2-ai-review.yaml
    - protein: UniProtKB:P61296
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:Q61039
      gene_review: genes/human/HAND2/HAND2-ai-review.yaml
    - protein: UniProtKB:Q61039
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19008477
      assigned_by: BHF-UCL
  - go_id: GO:0007538
    label: primary sex determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 7
    rate_ratio: 0.0161
    p_value: 1.61e-06
    q_value: 1.41e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q13285
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9590178
      assigned_by: PINC
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0007538
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0007538
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0007538
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0007538
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0007538
  - go_id: GO:0010286
    label: heat acclimation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 14
    rate_ratio: 0.0161
    p_value: 2.4e-12
    q_value: 4.29e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F7DAU7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2892
    - protein: UniProtKB:P13504
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:2892
  - go_id: GO:0007502
    label: digestive tract mesoderm development
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 7
    rate_ratio: 0.0161
    p_value: 1.61e-06
    q_value: 1.41e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q62226
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3673
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0007502
  - go_id: GO:0098975
    label: postsynapse of neuromuscular junction
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 20
    rate_ratio: 0.0169
    p_value: 3.47e-17
    q_value: 9.43e-16
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YSV9
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036192|PANTHER:PTN001263482
    - protein: UniProtKB:Q9R0C0
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036192|PANTHER:PTN001263482
    - protein: UniProtKB:Q9UL45
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036192|PANTHER:PTN001263482
      gene_review: genes/human/BLOC1S6/BLOC1S6-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0098975
  - go_id: GO:0001934
    label: positive regulation of protein phosphorylation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 507
      Invertebrates: 1
    rate_ratio: 0.0175
    p_value: 2.97e-22
    q_value: 1.07e-20
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0K3AV08
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:22388962
      assigned_by: UniProt
  - go_id: GO:0043035
    label: chromatin insulator sequence binding
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 19
    rate_ratio: 0.0178
    p_value: 2.97e-16
    q_value: 7.49e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZWP6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P49711|ensembl:ENSP00000264010
    - protein: UniProtKB:P49711
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:17827499
      assigned_by: UniProt
      gene_review: genes/human/CTCF/CTCF-ai-review.yaml
    - protein: UniProtKB:Q61164
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P49711|ensembl:ENSP00000264010
    - protein: UniProtKB:Q61164
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P49711
  - go_id: GO:0042023
    label: DNA endoreduplication
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 18
    rate_ratio: 0.0188
    p_value: 2.53e-15
    q_value: 6.05e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZZK0
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q62384|ensembl:ENSMUSP00000117725
    - protein: UniProtKB:O75312
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q62384|ensembl:ENSMUSP00000117725
    - protein: UniProtKB:O75312
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q62384
    - protein: UniProtKB:Q62384
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:15767679
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0042023
  - go_id: GO:0048858
    label: cell projection morphogenesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 12
    rate_ratio: 0.0188
    p_value: 1.77e-10
    q_value: 2.61e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9UNF0
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9WVE8
    - protein: UniProtKB:Q9WVE8
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20188097
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0048858
  - go_id: GO:0045111
    label: intermediate filament cytoskeleton
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 438
      Invertebrates: 1
    rate_ratio: 0.0202
    p_value: 4.12e-19
    q_value: 1.28e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18336
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:12082149
      assigned_by: WB
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0045111
  - go_id: GO:0034353
    label: mRNA 5'-diphosphatase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 11
    rate_ratio: 0.0205
    p_value: 1.5e-09
    q_value: 1.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O70348
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0030793|MGI:MGI:1890444|PANTHER:PTN000273640|PomBase:SPAC19D5.06c|SGD:S000003215
    - protein: UniProtKB:O70348
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:23523372
      assigned_by: UniProt
    - protein: UniProtKB:O77932
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0030793|MGI:MGI:1890444|PANTHER:PTN000273640|PomBase:SPAC19D5.06c|SGD:S000003215
    - protein: UniProtKB:O77932
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:O70348
  - go_id: GO:0033365
    label: protein localization to organelle
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 11
    rate_ratio: 0.0205
    p_value: 1.5e-09
    q_value: 1.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P83436
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:16420527
      assigned_by: UniProt
      gene_review: genes/human/COG7/COG7-ai-review.yaml
    - protein: UniProtKB:Q96JB2
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:16420527
      assigned_by: UniProt
  - go_id: GO:0045175
    label: basal protein localization
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 11
    rate_ratio: 0.0205
    p_value: 1.5e-09
    q_value: 1.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2AS98
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:16831833
      assigned_by: MGI
    - protein: UniProtKB:P28660
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:16831833
      assigned_by: MGI
  - go_id: GO:0060291
    label: long-term synaptic potentiation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 420
      Invertebrates: 1
    rate_ratio: 0.0211
    p_value: 2.71e-18
    q_value: 7.95e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9XTN2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:27048332
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0060291
  - go_id: GO:0015930
    label: glutamate synthase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 5
    rate_ratio: 0.0226
    p_value: 0.000118
    q_value: 0.000709
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0ACI8PY38
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002932
  - go_id: GO:0140543
    label: positive regulation of piRNA transcription
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 10
    rate_ratio: 0.0226
    p_value: 1.25e-08
    q_value: 1.47e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10243
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:P51960
    - protein: UniProtKB:P51960
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:23523368
      assigned_by: UniProt
  - go_id: GO:0008613
    label: diuretic hormone activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 5
    rate_ratio: 0.0226
    p_value: 0.000118
    q_value: 0.000709
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P16860
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:14960748
      assigned_by: UniProt
  - go_id: GO:0046958
    label: nonassociative learning
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 10
    rate_ratio: 0.0226
    p_value: 1.25e-08
    q_value: 1.47e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q13387
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9ERE9|ensembl:ENSMUSP00000023291
    - protein: UniProtKB:Q13387
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:Q9ERE9
    - protein: UniProtKB:Q9ERE9
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:21048139
      assigned_by: BHF-UCL
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0046958
  - go_id: GO:0071329
    label: cellular response to sucrose stimulus
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 10
    rate_ratio: 0.0226
    p_value: 1.25e-08
    q_value: 1.47e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q16602
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:10882736
      assigned_by: UniProt
    - protein: UniProtKB:Q9R1W5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q16602|ensembl:ENSP00000376177
    - protein: UniProtKB:Q9R1W5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q16602
  - go_id: GO:0001178
    label: regulation of transcriptional start site selection at RNA polymerase II promoter
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 10
    rate_ratio: 0.0226
    p_value: 1.25e-08
    q_value: 1.47e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q69Z61
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:33235983
      assigned_by: UniProt
    - protein: UniProtKB:Q96N64
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q69Z61|ensembl:ENSMUSP00000054154
    - protein: UniProtKB:Q96N64
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q69Z61
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0001178
  - go_id: GO:1905808
    label: positive regulation of synapse pruning
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 10
    rate_ratio: 0.0226
    p_value: 1.25e-08
    q_value: 1.47e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q99NH8
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9NZC2|ensembl:ENSP00000362205
    - protein: UniProtKB:Q99NH8
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NZC2
    - protein: UniProtKB:Q99NH8
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q9NZC2
    - protein: UniProtKB:Q9NZC2
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:33097708
      assigned_by: ARUK-UCL
      gene_review: genes/human/TREM2/TREM2-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:1905808
  - go_id: GO:0019102
    label: male somatic sex determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 5
    rate_ratio: 0.0226
    p_value: 0.000118
    q_value: 0.000709
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P19091
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:5452809
      assigned_by: MGI
      with_from: MGI:MGI:1856319
      gene_review: genes/mouse/Ar/Ar-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0019102
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0019102
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0019102
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0019102
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0019102
  - go_id: GO:0071444
    label: cellular response to pheromone
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 5
    rate_ratio: 0.0226
    p_value: 0.000118
    q_value: 0.000709
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P63078
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:23836683
      assigned_by: MGI
      with_from: MGI:MGI:5584308
  - go_id: GO:0048621
    label: post-embryonic digestive tract morphogenesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 5
    rate_ratio: 0.0226
    p_value: 0.000118
    q_value: 0.000709
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P97334
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10926756
      assigned_by: MGI
      with_from: MGI:MGI:2448069
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0048621
  - go_id: GO:0007508
    label: larval heart development
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 5
    rate_ratio: 0.0226
    p_value: 0.000118
    q_value: 0.000709
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZN40
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0028573|PANTHER:PTN008655974
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33213 (Bilateria), on GO:0007508
  - go_id: GO:0071953
    label: elastic fiber
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 389
      Invertebrates: 1
    rate_ratio: 0.0228
    p_value: 6.93e-17
    q_value: 1.86e-15
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A061ACI3
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084594
  - go_id: GO:0001650
    label: fibrillar center
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 1141
      Invertebrates: 3
    rate_ratio: 0.0233
    p_value: 5.38e-48
    q_value: 5.15e-46
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B7WNB1
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001809025|UniProtKB:Q15572
    - protein: UniProtKB:Q22053
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:36329008
      assigned_by: UniProt
      gene_review: genes/worm/fib-1/fib-1-ai-review.yaml
    - protein: UniProtKB:Q9TYK1
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:36329008
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0001650
  - go_id: GO:0061844
    label: antimicrobial humoral immune response mediated by antimicrobial peptide
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 354
      Invertebrates: 1
    rate_ratio: 0.025
    p_value: 2.67e-15
    q_value: 6.35e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P41964
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:18212107
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0061844
  - go_id: GO:0046680
    label: response to DDT
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 9
    rate_ratio: 0.0251
    p_value: 1.03e-07
    q_value: 1.07e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P14635
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P30277|ensembl:ENSRNOP00000082369
      gene_review: genes/human/CCNB1/CCNB1-ai-review.yaml
    - protein: UniProtKB:P24860
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P30277|ensembl:ENSRNOP00000082369
      gene_review: genes/mouse/Ccnb1/Ccnb1-ai-review.yaml
  - go_id: GO:0001941
    label: postsynaptic membrane organization
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 13
    rate_ratio: 0.026
    p_value: 1.0e-10
    q_value: 1.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09690
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P11230|ensembl:ENSP00000304290
    - protein: UniProtKB:P09690
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P11230
    - protein: UniProtKB:P11230
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:8651643
      assigned_by: UniProt
      gene_review: genes/human/CHRNB1/CHRNB1-ai-review.yaml
    - protein: UniProtKB:P48540
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:15381279
      assigned_by: MGI
  - go_id: GO:0070073
    label: clustering of voltage-gated calcium channels
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 13
    rate_ratio: 0.026
    p_value: 1.0e-10
    q_value: 1.52e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D3YVF0
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:27693258
      assigned_by: CACAO
    - protein: UniProtKB:Q80TE7
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:28363979
      assigned_by: UniProt
    - protein: UniProtKB:Q96NW7
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q80TE7
  - go_id: GO:0002244
    label: hematopoietic progenitor cell differentiation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 331
      Invertebrates: 1
    rate_ratio: 0.0268
    p_value: 2.93e-14
    q_value: 6.25e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7K486
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1924063|PANTHER:PTN000527910
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0002244
  - go_id: GO:0032868
    label: response to insulin
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 319
      Invertebrates: 1
    rate_ratio: 0.0278
    p_value: 1.02e-13
    q_value: 2.04e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VXH3
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:22132213
      assigned_by: FlyBase
      with_from: FB:FBgn0283499
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0032868
  - go_id: GO:1902075
    label: cellular response to salt
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 8
    rate_ratio: 0.0282
    p_value: 8.34e-07
    q_value: 7.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O14980
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q80U96|ensembl:ENSRNOP00000087052
    - protein: UniProtKB:Q6P5F9
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q80U96|ensembl:ENSRNOP00000087052
  - go_id: GO:1904333
    label: positive regulation of error-prone translesion synthesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O94782
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-110314
      assigned_by: Reactome
  - go_id: GO:0004097
    label: catechol oxidase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P17643
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-8878581
      assigned_by: Reactome
      gene_review: genes/human/TYRP1/TYRP1-ai-review.yaml
  - go_id: GO:0030237
    label: female sex determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 12
    rate_ratio: 0.0282
    p_value: 8.03e-10
    q_value: 1.11e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YZ32
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P56705|ensembl:ENSP00000290167
    - protein: UniProtKB:P22724
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P56705|ensembl:ENSP00000290167
    - protein: UniProtKB:P22724
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P56705
    - protein: UniProtKB:P22724
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: PMID:11283799
      assigned_by: UniProt
      with_from: UniProtKB:P56705
    - protein: UniProtKB:P56705
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:11283799
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0030237
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0030237
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0030237
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0030237
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030237
  - go_id: GO:0008275
    label: gamma-tubulin small complex
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9HC77
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:11003675
      assigned_by: UniProt
      gene_review: genes/human/CPAP/CPAP-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0008275
  - go_id: GO:0007440
    label: foregut morphogenesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 8
    rate_ratio: 0.0282
    p_value: 8.34e-07
    q_value: 7.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2AIX5
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:16107537
      assigned_by: MGI
      with_from: MGI:MGI:2684314,MGI:MGI:2684317
    - protein: UniProtKB:Q01705
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:16107537
      assigned_by: MGI
      with_from: MGI:MGI:2684314,MGI:MGI:2684317
      gene_review: genes/mouse/Notch1/Notch1-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0007440
  - go_id: GO:0010085
    label: polarity specification of proximal/distal axis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 8
    rate_ratio: 0.0282
    p_value: 8.34e-07
    q_value: 7.67e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P43021
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:14511481
      assigned_by: MGI
    - protein: UniProtKB:Q64527
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:16256739
      assigned_by: MGI
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0010085
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0010085
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0010085
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0010085
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0010085
  - go_id: GO:0097376
    label: interneuron axon guidance
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P70396
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25937343
      assigned_by: MGI
      with_from: MGI:MGI:2180475
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0097376
  - go_id: GO:2001229
    label: negative regulation of response to gamma radiation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P97313
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:D3ZTN0|ensembl:ENSRNOP00000037412
    - protein: UniProtKB:P97313
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1308982
  - go_id: GO:0060280
    label: negative regulation of ovulation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q3UVY1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:19887567
      assigned_by: MGI
      with_from: MGI:MGI:4442841
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0060280
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0060280
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0060280
  - go_id: GO:0005118
    label: sevenless binding
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: true
    flagged_annotations:
    - protein: UniProtKB:Q8K3J9
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR002956
      gene_review: genes/mouse/Gprc5c/Gprc5c-ai-review.yaml
  - go_id: GO:0060573
    label: cell fate specification involved in pattern specification
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q91035
      taxon: NCBITaxon:9031
      evidence: TAS
      reference: PMID:11336495
      assigned_by: AgBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0060573
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0060573
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0060573
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0060573
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0060573
  - go_id: GO:1903859
    label: regulation of dendrite extension
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 4
    rate_ratio: 0.0282
    p_value: 0.000972
    q_value: 0.00472
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q91987
      taxon: NCBITaxon:9031
      evidence: IDA
      reference: PMID:23035107
      assigned_by: AgBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:1903859
  - go_id: GO:0031667
    label: response to nutrient levels
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 301
      Invertebrates: 1
    rate_ratio: 0.0294
    p_value: 6.6e-13
    q_value: 1.23e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O62263
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:3033336|PANTHER:PTN001029016|UniProtKB:Q5T011
  - go_id: GO:0071222
    label: cellular response to lipopolysaccharide
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 583
      Invertebrates: 2
    rate_ratio: 0.0304
    p_value: 3.03e-24
    q_value: 1.24e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q24151
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:10764759
      assigned_by: FlyBase
    - protein: UniProtKB:Q9V3Q6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16451733
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0071222
  - go_id: GO:0051707
    label: response to other organism
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 290
      Invertebrates: 1
    rate_ratio: 0.0305
    p_value: 2.06e-12
    q_value: 3.73e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VR90
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00029118
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0051707
  - go_id: GO:0016503
    label: pheromone receptor activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 288
      Invertebrates: 1
    rate_ratio: 0.0308
    p_value: 2.54e-12
    q_value: 4.53e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O45767
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:27799655
      assigned_by: UniProt
  - go_id: GO:0071254
    label: cytoplasmic U snRNP body
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 11
    rate_ratio: 0.0308
    p_value: 6.35e-09
    q_value: 7.78e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E1BY33
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033554|PANTHER:PTN001080983
    - protein: UniProtKB:Q8QZX5
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033554|PANTHER:PTN001080983
    - protein: UniProtKB:Q969L4
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0033554|PANTHER:PTN001080983
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0071254
  - go_id: GO:0032496
    label: response to lipopolysaccharide
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 571
      Invertebrates: 2
    rate_ratio: 0.031
    p_value: 1.05e-23
    q_value: 4.12e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q27571
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:97361|MGI:MGI:97362|PANTHER:PTN001066032|RGD:3184|RGD:3185|RGD:3186|ZFIN:ZDB-GENE-040305-1|ZFIN:ZDB-GENE-080916-1
    - protein: UniProtKB:Q9W278
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:15297616
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0032496
  - go_id: GO:1904731
    label: positive regulation of intestinal lipid absorption
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 7
    rate_ratio: 0.0322
    p_value: 6.6e-06
    q_value: 5.16e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q80XD8
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:33168624
      assigned_by: UniProt
    - protein: UniProtKB:Q96NZ9
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q80XD8
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:1904731
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:1904731
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:1904731
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:1904731
  - go_id: GO:0034059
    label: response to anoxia
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 7
    rate_ratio: 0.0322
    p_value: 6.6e-06
    q_value: 5.16e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0N4SVY6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3239
    - protein: UniProtKB:P97926
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3239
  - go_id: GO:0030218
    label: erythrocyte differentiation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 273
      Invertebrates: 1
    rate_ratio: 0.0325
    p_value: 1.2e-11
    q_value: 2.02e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4JD50
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00085625
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0030218
  - go_id: GO:0048337
    label: positive regulation of mesodermal cell fate specification
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 10
    rate_ratio: 0.0339
    p_value: 4.93e-08
    q_value: 5.31e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1A7V3
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P56704|ensembl:ENSP00000284523
    - protein: UniProtKB:P27467
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P56704|ensembl:ENSP00000284523
    - protein: UniProtKB:P27467
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P56704
    - protein: UniProtKB:P56704
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:20559569
      assigned_by: BHF-UCL
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0048337
  - go_id: GO:0008373
    label: sialyltransferase activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 509
      Invertebrates: 2
    rate_ratio: 0.0348
    p_value: 6.34e-21
    q_value: 2.17e-19
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KVF5
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001675
    - protein: UniProtKB:Q9W121
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR001675
  - go_id: GO:0032728
    label: positive regulation of interferon-beta production
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 253
      Invertebrates: 1
    rate_ratio: 0.035
    p_value: 9.46e-11
    q_value: 1.44e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q02335
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:O94826
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0032728
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0032728
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0032728
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0032728
  - go_id: GO:0050728
    label: negative regulation of inflammatory response
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 491
      Invertebrates: 2
    rate_ratio: 0.0361
    p_value: 4.05e-20
    q_value: 1.34e-18
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5ECR9
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1352462|MGI:MGI:1352464|PANTHER:PTN000637752
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0050728
    - protein: UniProtKB:P34021
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1352462|MGI:MGI:1352464|PANTHER:PTN000637752
      gene_review: genes/DROME/EcR/EcR-ai-review.yaml
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0050728
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0050728
  - go_id: GO:0010976
    label: positive regulation of neuron projection development
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 731
      Invertebrates: 3
    rate_ratio: 0.0364
    p_value: 1.59e-29
    q_value: 7.72e-28
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:H2KZX7
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN004608122|RGD:619793|UniProtKB:Q13905
    - protein: UniProtKB:O77086
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN004608122|RGD:619793|UniProtKB:Q13905
    - protein: UniProtKB:Q9VZH2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:8817456
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0010976
  - go_id: GO:0140541
    label: piRNA transcription
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 6
    rate_ratio: 0.0376
    p_value: 5.08e-05
    q_value: 0.000332
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0A6YY25
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:3650217|PANTHER:PTN008474306
    - protein: UniProtKB:A0A0A6YY25
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:28292424
      assigned_by: GO_Central
    - protein: UniProtKB:B2RXH4
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:3650217|PANTHER:PTN008474306
    - protein: UniProtKB:B2RXH4
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:A0A0A6YY25|ensembl:ENSMUSP00000142247
    - protein: UniProtKB:B2RXH4
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:A0A0A6YY25
  - go_id: GO:0048640
    label: negative regulation of developmental growth
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 6
    rate_ratio: 0.0376
    p_value: 5.08e-05
    q_value: 0.000332
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P22607
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: PMID:20582225
      assigned_by: BHF-UCL
      with_from: UniProtKB:Q61851
      gene_review: genes/human/FGFR3/FGFR3-ai-review.yaml
    - protein: UniProtKB:Q61851
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20582225
      assigned_by: BHF-UCL
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0048640
  - go_id: GO:0021700
    label: developmental maturation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 6
    rate_ratio: 0.0376
    p_value: 5.08e-05
    q_value: 0.000332
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P14873
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P15205|ensembl:ENSRNOP00000023460
    - protein: UniProtKB:P46821
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P15205|ensembl:ENSRNOP00000023460
  - go_id: GO:0007495
    label: visceral mesoderm-endoderm interaction involved in midgut development
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 6
    rate_ratio: 0.0376
    p_value: 5.08e-05
    q_value: 0.000332
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q12952
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q64731
    - protein: UniProtKB:Q64731
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:9203584
      assigned_by: MGI
      with_from: MGI:MGI:2178230
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0007495
  - go_id: GO:0010446
    label: response to alkaline pH
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 9
    rate_ratio: 0.0376
    p_value: 3.75e-07
    q_value: 3.6e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AJC8
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8TDN7|ensembl:ENSP00000301452
    - protein: UniProtKB:Q8R4X1
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8TDN7|ensembl:ENSP00000301452
    - protein: UniProtKB:Q8R4X1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q8TDN7
    - protein: UniProtKB:Q8TDN7
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:17713573
      assigned_by: BHF-UCL
      gene_review: genes/human/ACER1/ACER1-ai-review.yaml
  - go_id: GO:0016938
    label: kinesin I complex
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 3
    rate_ratio: 0.0376
    p_value: 0.00771
    q_value: 0.0289
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9H0B6
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:20510358
      assigned_by: BHF-UCL
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0016938
  - go_id: GO:0005976
    label: polysaccharide metabolic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 3
    rate_ratio: 0.0376
    p_value: 0.00771
    q_value: 0.0289
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P70419
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:25107907
      assigned_by: MGI
  - go_id: GO:0008898
    label: S-adenosylmethionine-homocysteine S-methyltransferase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 3
    rate_ratio: 0.0376
    p_value: 0.00771
    q_value: 0.0289
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q91WS4
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: PMID:11087663
      assigned_by: MGI
      with_from: UniProtKB:Q9H2M3
  - go_id: GO:0003904
    label: deoxyribodipyrimidine photo-lyase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 1
      Invertebrates: 3
    rate_ratio: 0.0376
    p_value: 0.00771
    q_value: 0.0289
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YRT6
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000025285|UniProtKB:Q6F6A2
    - protein: UniProtKB:A0A8V0YRT6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR008148
    - protein: UniProtKB:A0A8V0YRT6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:4.1.99.3|EC:4.1.99.3
  - go_id: GO:0009951
    label: polarity specification of dorsal/ventral axis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 6
    rate_ratio: 0.0376
    p_value: 5.08e-05
    q_value: 0.000332
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q90752
      taxon: NCBITaxon:9031
      evidence: NAS
      reference: PMID:11336495
      assigned_by: AgBase
    - protein: UniProtKB:Q91035
      taxon: NCBITaxon:9031
      evidence: NAS
      reference: PMID:11336495
      assigned_by: AgBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0009951
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0009951
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0009951
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0009951
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0009951
  - go_id: GO:0043194
    label: axon initial segment
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 235
      Invertebrates: 1
    rate_ratio: 0.0377
    p_value: 6.04e-10
    q_value: 8.37e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P34609
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:23633144
      assigned_by: WB
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0043194
  - go_id: GO:0050796
    label: regulation of insulin secretion
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 231
      Invertebrates: 1
    rate_ratio: 0.0384
    p_value: 9.12e-10
    q_value: 1.25e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:X2JDZ1
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: PMID:29768204
      assigned_by: FlyBase
      with_from: UniProtKB:Q9NRD5
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0050796
  - go_id: GO:0001818
    label: negative regulation of cytokine production
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 227
      Invertebrates: 1
    rate_ratio: 0.039
    p_value: 1.38e-09
    q_value: 1.85e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q00168
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:29017032
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0001818
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0001818
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0001818
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0001818
  - go_id: GO:2000042
    label: negative regulation of double-strand break repair via homologous recombination
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 227
      Invertebrates: 1
    rate_ratio: 0.039
    p_value: 1.38e-09
    q_value: 1.85e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EFF7
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:30612738
      assigned_by: UniProt
  - go_id: GO:0051893
    label: regulation of focal adhesion assembly
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 222
      Invertebrates: 1
    rate_ratio: 0.0399
    p_value: 2.3e-09
    q_value: 2.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8MNT0
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000399552|UniProtKB:Q9UPQ0
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0051893
  - go_id: GO:0032391
    label: photoreceptor connecting cilium
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 222
      Invertebrates: 1
    rate_ratio: 0.0399
    p_value: 2.3e-09
    q_value: 2.99e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P10040
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:32579558
      assigned_by: UniProt
      gene_review: genes/DROME/crb/crb-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0032391
  - go_id: GO:0099149
    label: regulation of postsynaptic neurotransmitter receptor internalization
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 221
      Invertebrates: 1
    rate_ratio: 0.0401
    p_value: 2.55e-09
    q_value: 3.28e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VP80
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1196356|PANTHER:PTN000070822|RGD:1596313
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0099149
  - go_id: GO:0032281
    label: AMPA glutamate receptor complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 217
      Invertebrates: 1
    rate_ratio: 0.0408
    p_value: 3.84e-09
    q_value: 4.81e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EDT2
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1316660|MGI:MGI:1859165|MGI:MGI:1859167|PANTHER:PTN000251098|RGD:628803|RGD:628804|RGD:628805|RGD:628807|RGD:628808|RGD:71095
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0032281
  - go_id: GO:0007339
    label: binding of sperm to zona pellucida
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 214
      Invertebrates: 1
    rate_ratio: 0.0414
    p_value: 5.22e-09
    q_value: 6.47e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VTJ4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26101846
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:58024 (Spermatophyta), on GO:0007339
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0007339
  - go_id: GO:0005121
    label: Toll binding
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 8
    rate_ratio: 0.0423
    p_value: 2.78e-06
    q_value: 2.34e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6SPW1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:735043
    - protein: UniProtKB:P22366
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q6Y1S1|ensembl:ENSRNOP00000018341
    - protein: UniProtKB:P22366
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:735043
    - protein: UniProtKB:Q99836
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q6Y1S1|ensembl:ENSRNOP00000018341
      gene_review: genes/human/MYD88/MYD88-ai-review.yaml
  - go_id: GO:0120283
    label: protein serine/threonine kinase binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 209
      Invertebrates: 1
    rate_ratio: 0.0424
    p_value: 8.71e-09
    q_value: 1.05e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P22981
      taxon: NCBITaxon:6239
      evidence: IPI
      reference: PMID:9674433
      assigned_by: WB
      with_from: UniProtKB:Q07292
      gene_review: genes/worm/let-60/let-60-ai-review.yaml
  - go_id: GO:0005862
    label: muscle thin filament tropomyosin
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 205
      Invertebrates: 1
    rate_ratio: 0.0432
    p_value: 1.31e-08
    q_value: 1.53e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q20334
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:15743415
      assigned_by: WB
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0005862
  - go_id: GO:0120212
    label: sperm head-tail coupling apparatus
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 204
      Invertebrates: 1
    rate_ratio: 0.0434
    p_value: 1.45e-08
    q_value: 1.68e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VVW9
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR042769
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0120212
  - go_id: GO:0071466
    label: cellular response to xenobiotic stimulus
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 204
      Invertebrates: 1
    rate_ratio: 0.0434
    p_value: 1.45e-08
    q_value: 1.68e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O45365
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:23922869
      assigned_by: UniProt
  - go_id: GO:0042470
    label: melanosome
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 611
      Invertebrates: 3
    rate_ratio: 0.0435
    p_value: 3.5e-24
    q_value: 1.42e-22
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A021WZA4
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0161
    - protein: UniProtKB:M9PGI6
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0161
    - protein: UniProtKB:O77434
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0161
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:6237 (Caenorhabditis), on GO:0042470
    - only_in_taxon NCBITaxon:33213 (Bilateria), on GO:0042470
  - go_id: GO:0008009
    label: chemokine activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 202
      Invertebrates: 1
    rate_ratio: 0.0439
    p_value: 1.78e-08
    q_value: 2.04e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W3M4
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:33758182
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0008009
  - go_id: GO:0051497
    label: negative regulation of stress fiber assembly
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 202
      Invertebrates: 1
    rate_ratio: 0.0439
    p_value: 1.78e-08
    q_value: 2.04e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VTU3
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:22110359
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0051497
  - go_id: GO:1905088
    label: positive regulation of synaptonemal complex assembly
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A087WRU1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:37612290
      assigned_by: UniProt
    - protein: UniProtKB:Q86WS4
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:A0A087WRU1|ensembl:ENSMUSP00000140772
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:1905088
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1905088
  - go_id: GO:0051316
    label: attachment of meiotic spindle microtubules to kinetochore
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q66JQ7
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:35167144
      assigned_by: UniProt
    - protein: UniProtKB:Q8NG31
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q66JQ7|ensembl:ENSMUSP00000097140
    - protein: UniProtKB:Q8NG31
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q66JQ7
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0051316
  - go_id: GO:0031475
    label: myosin V complex
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q96FJ2
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9D0M5|ensembl:ENSMUSP00000020775
    - protein: UniProtKB:Q96FJ2
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9D0M5
    - protein: UniProtKB:Q9D0M5
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:14561217
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0031475
  - go_id: GO:0003031
    label: detection of carbon dioxide
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0U1RPR8
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:17702944
      assigned_by: UniProt
    - protein: UniProtKB:A0A8V0XFC8
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:A0A0U1RPR8|ensembl:ENSMUSP00000146093
  - go_id: GO:0010092
    label: specification of animal organ identity
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2AR81
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20615956
      assigned_by: MGI
      with_from: MGI:MGI:2179766
    - protein: UniProtKB:Q64336
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:20615956
      assigned_by: MGI
      with_from: MGI:MGI:2179766
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0010092
  - go_id: GO:0070303
    label: negative regulation of stress-activated protein kinase signaling cascade
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A2ASW6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NYL2
    - protein: UniProtKB:Q9ESL4
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9NYL2
  - go_id: GO:1990399
    label: epithelium regeneration
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 5
    rate_ratio: 0.0451
    p_value: 0.000378
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B7ZCA6
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:31292548
      assigned_by: MGI
    - protein: UniProtKB:Q8R116
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:31292548
      assigned_by: MGI
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:1990399
  - go_id: GO:0097542
    label: ciliary tip
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 390
      Invertebrates: 2
    rate_ratio: 0.0454
    p_value: 1.27e-15
    q_value: 3.08e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5ECV5
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1926045|PANTHER:PTN000382362
    - protein: UniProtKB:Q9VTQ3
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036219|PANTHER:PTN001093369
    - protein: UniProtKB:Q9VTQ3
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:24067530
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0097542
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0097542
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0097542
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0097542
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0097542
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0097542
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0097542
  - go_id: GO:0031669
    label: cellular response to nutrient levels
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 388
      Invertebrates: 2
    rate_ratio: 0.0457
    p_value: 1.56e-15
    q_value: 3.77e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VQG9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:29084242
      assigned_by: FlyBase
    - protein: UniProtKB:Q9W3N1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:27500738
      assigned_by: FlyBase
  - go_id: GO:0097191
    label: extrinsic apoptotic signaling pathway
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 192
      Invertebrates: 1
    rate_ratio: 0.0461
    p_value: 4.95e-08
    q_value: 5.31e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V3B4
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:109324|PANTHER:PTN008354262|UniProtKB:Q13158
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0097191
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0097191
  - go_id: GO:0019955
    label: cytokine binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 192
      Invertebrates: 1
    rate_ratio: 0.0461
    p_value: 4.95e-08
    q_value: 5.31e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P08953
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:12872120
      assigned_by: FlyBase
      with_from: FB:FBgn0003495
      gene_review: genes/DROME/Tl/Tl-ai-review.yaml
    - protein: UniProtKB:P08953
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:17324925
      assigned_by: FlyBase
      with_from: FB:FBgn0003495
      gene_review: genes/DROME/Tl/Tl-ai-review.yaml
    - protein: UniProtKB:P08953
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:24733933
      assigned_by: FlyBase
      with_from: FB:FBgn0003495
      gene_review: genes/DROME/Tl/Tl-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0019955
  - go_id: GO:0008589
    label: regulation of smoothened signaling pathway
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 192
      Invertebrates: 1
    rate_ratio: 0.0461
    p_value: 4.95e-08
    q_value: 5.31e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VJ33
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:12231629
      assigned_by: UniProt
  - go_id: GO:0050852
    label: T cell receptor signaling pathway
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 566
      Invertebrates: 3
    rate_ratio: 0.047
    p_value: 3.44e-22
    q_value: 1.23e-20
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A8JUS8
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001024117|UniProtKB:O15304
    - protein: UniProtKB:Q8IRY8
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001024117|UniProtKB:O15304
    - protein: UniProtKB:Q9I7Z9
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001024117|UniProtKB:O15304
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0050852
  - go_id: GO:1902894
    label: negative regulation of miRNA transcription
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 188
      Invertebrates: 1
    rate_ratio: 0.0471
    p_value: 7.44e-08
    q_value: 7.85e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q65ZG8
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:24699545
      assigned_by: WB
  - go_id: GO:0042749
    label: regulation of circadian sleep/wake cycle
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 7
    rate_ratio: 0.0484
    p_value: 2.01e-05
    q_value: 0.000142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1A1C9
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q3UV55|ensembl:ENSMUSP00000069505
    - protein: UniProtKB:P20393
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q3UV55|ensembl:ENSMUSP00000069505
    - protein: UniProtKB:P20393
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q3UV55
    - protein: UniProtKB:Q3UV55
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:30792350
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0042749
  - go_id: GO:0015117
    label: thiosulfate transmembrane transporter activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 7
    rate_ratio: 0.0484
    p_value: 2.01e-05
    q_value: 0.000142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AJQ4
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027610|FB:FBgn0033248|PANTHER:PTN000756618
    - protein: UniProtKB:Q9QZD8
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027610|FB:FBgn0033248|PANTHER:PTN000756618
    - protein: UniProtKB:Q9UBX3
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027610|FB:FBgn0033248|PANTHER:PTN000756618
      gene_review: genes/human/SLC25A10/SLC25A10-ai-review.yaml
  - go_id: GO:0015709
    label: thiosulfate transport
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 7
    rate_ratio: 0.0484
    p_value: 2.01e-05
    q_value: 0.000142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1AJQ4
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027610|FB:FBgn0033248|PANTHER:PTN000756618
    - protein: UniProtKB:Q9QZD8
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027610|FB:FBgn0033248|PANTHER:PTN000756618
    - protein: UniProtKB:Q9UBX3
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0027610|FB:FBgn0033248|PANTHER:PTN000756618
      gene_review: genes/human/SLC25A10/SLC25A10-ai-review.yaml
  - go_id: GO:0150008
    label: bulk synaptic vesicle endocytosis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 7
    rate_ratio: 0.0484
    p_value: 2.01e-05
    q_value: 0.000142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1D5PHF8
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0261722|PANTHER:PTN000999743
    - protein: UniProtKB:Q8BG21
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0261722|PANTHER:PTN000999743
    - protein: UniProtKB:Q9UGQ2
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0261722|PANTHER:PTN000999743
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0150008
  - go_id: GO:0010811
    label: positive regulation of cell-substrate adhesion
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 178
      Invertebrates: 1
    rate_ratio: 0.0498
    p_value: 2.06e-07
    q_value: 2.05e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VB78
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:25681394
      assigned_by: FlyBase
  - go_id: GO:0055007
    label: cardiac muscle cell differentiation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 176
      Invertebrates: 1
    rate_ratio: 0.0503
    p_value: 2.52e-07
    q_value: 2.47e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P22711
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00084649
      gene_review: genes/DROME/tin/tin-ai-review.yaml
    - protein: UniProtKB:P22711
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16987868
      assigned_by: FlyBase
      gene_review: genes/DROME/tin/tin-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33213 (Bilateria), on GO:0055007
  - go_id: GO:0031640
    label: killing of cells of another organism
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 339
      Invertebrates: 2
    rate_ratio: 0.0523
    p_value: 2.26e-13
    q_value: 4.41e-12
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O44662
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:27672387
      assigned_by: WB
    - protein: UniProtKB:Q9XXF1
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:27672387
      assigned_by: WB
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0031640
  - go_id: GO:0051216
    label: cartilage development
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 330
      Invertebrates: 2
    rate_ratio: 0.0537
    p_value: 5.61e-13
    q_value: 1.06e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P34623
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089273
    - protein: UniProtKB:Q9VDD1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00089273
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0051216
  - go_id: GO:0030315
    label: T-tubule
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 494
      Invertebrates: 3
    rate_ratio: 0.0538
    p_value: 5.09e-19
    q_value: 1.57e-17
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0C4DHF6
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17881734
      assigned_by: FlyBase
    - protein: UniProtKB:C0HJH4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:23970561
      assigned_by: FlyBase
    - protein: UniProtKB:C0HJH4
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0505
    - protein: UniProtKB:Q8IP22
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:30093550
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0030315
  - go_id: GO:2001244
    label: positive regulation of intrinsic apoptotic signaling pathway
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 158
      Invertebrates: 1
    rate_ratio: 0.0561
    p_value: 1.56e-06
    q_value: 1.37e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VFM3
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:34767445
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:2001244
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:2001244
  - go_id: GO:0046189
    label: phenol-containing compound biosynthetic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YG39
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026420
    - protein: UniProtKB:A0A8V0YG49
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026420
    - protein: UniProtKB:A0AAQ5BHT3
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00026420
  - go_id: GO:0007500
    label: mesodermal cell fate determination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O43474
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:8940147
      assigned_by: PINC
    - protein: UniProtKB:P21275
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:7657163
      assigned_by: MGI
      with_from: MGI:MGI:1857137
    - protein: UniProtKB:Q9C019
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:10207104
      assigned_by: PINC
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0007500
  - go_id: GO:0150013
    label: negative regulation of neuron projection arborization
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O43610
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q3UUD2
    - protein: UniProtKB:Q3UUD2
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:26089202
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0150013
  - go_id: GO:0006726
    label: eye pigment biosynthetic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P14679
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:7704033
      assigned_by: PINC
    - protein: UniProtKB:P51810
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:7647783
      assigned_by: PINC
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0006726
  - go_id: GO:0001507
    label: acetylcholine catabolic process in synaptic cleft
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P22303
      taxon: NCBITaxon:9606
      evidence: IC
      reference: PMID:1517212
      assigned_by: UniProt
      gene_review: genes/human/ACHE/ACHE-ai-review.yaml
    - protein: UniProtKB:P22303
      taxon: NCBITaxon:9606
      evidence: NAS
      reference: PMID:1517212
      assigned_by: UniProt
      gene_review: genes/human/ACHE/ACHE-ai-review.yaml
    - protein: UniProtKB:Q9Y215
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: PMID:9689136
      assigned_by: PINC
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0001507
  - go_id: GO:0008052
    label: sensory organ boundary specification
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A1B0GT57
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10479455
      assigned_by: MGI
      with_from: MGI:MGI:1933845
    - protein: UniProtKB:P34130
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: PMID:10479455
      assigned_by: UniProt
      with_from: UniProtKB:Q80VU4
    - protein: UniProtKB:Q80VU4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:10479455
      assigned_by: MGI
      with_from: MGI:MGI:1933845
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0008052
  - go_id: GO:1903394
    label: protein localization to kinetochore involved in kinetochore assembly
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1A857
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001038564|WB:WBGene00018900
    - protein: UniProtKB:P50748
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001038564|WB:WBGene00018900
    - protein: UniProtKB:Q8C3Y4
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001038564|WB:WBGene00018900
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:1903394
  - go_id: GO:0048613
    label: embryonic ectodermal digestive tract morphogenesis
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XN14
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q12946|ensembl:ENSP00000262426
    - protein: UniProtKB:Q12946
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:19500772
      assigned_by: DFLAT
    - protein: UniProtKB:Q61080
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q12946|ensembl:ENSP00000262426
    - protein: UniProtKB:Q61080
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q12946
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0048613
  - go_id: GO:0021682
    label: nerve maturation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q14118
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q62165|ensembl:ENSMUSP00000079294
      gene_review: genes/human/DAG1/DAG1-ai-review.yaml
    - protein: UniProtKB:Q62165
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:12797959
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0021682
  - go_id: GO:0060232
    label: delamination
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7Z591
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q80VW7|ensembl:ENSMUSP00000041614
      gene_review: genes/human/AKNA/AKNA-ai-review.yaml
    - protein: UniProtKB:Q7Z591
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q80VW7
      gene_review: genes/human/AKNA/AKNA-ai-review.yaml
    - protein: UniProtKB:Q80VW7
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:30787442
      assigned_by: UniProt
  - go_id: GO:0042065
    label: glial cell growth
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F1P3B6
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q3U5C7|ensembl:ENSMUSP00000049204
    - protein: UniProtKB:Q3U5C7
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:23420014
      assigned_by: MGI
      with_from: MGI:MGI:5502459
    - protein: UniProtKB:Q96MT3
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q3U5C7|ensembl:ENSMUSP00000049204
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0042065
  - go_id: GO:1903294
    label: regulation of glutamate secretion, neurotransmission
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5F468
      taxon: NCBITaxon:9031
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9JHE5
    - protein: UniProtKB:Q8CFE6
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9JHE5|ensembl:ENSRNOP00000031532
    - protein: UniProtKB:Q8CFE6
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:69420
    - protein: UniProtKB:Q8CFE6
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9JHE5
    - protein: UniProtKB:Q96QD8
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9JHE5|ensembl:ENSRNOP00000031532
    - protein: UniProtKB:Q96QD8
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9JHE5
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:1903294
  - go_id: GO:0010891
    label: negative regulation of triglyceride storage
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q99NH8
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:31902528
      assigned_by: ARUK-UCL
    - protein: UniProtKB:Q9NZC2
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q99NH8|ensembl:ENSMUSP00000024791
      gene_review: genes/human/TREM2/TREM2-ai-review.yaml
    - protein: UniProtKB:Q9NZC2
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: ARUK-UCL
      with_from: UniProtKB:Q99NH8
      gene_review: genes/human/TREM2/TREM2-ai-review.yaml
  - go_id: GO:0000706
    label: meiotic DNA double-strand break processing
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 6
    rate_ratio: 0.0564
    p_value: 0.000139
    q_value: 0.000821
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YQM9
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0002716|PANTHER:PTN000091177|WB:WBGene00004985
    - protein: UniProtKB:Q9WTK8
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0002716|PANTHER:PTN000091177|WB:WBGene00004985
    - protein: UniProtKB:Q9Y5K1
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0002716|PANTHER:PTN000091177|WB:WBGene00004985
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0000706
  - go_id: GO:0071678
    label: olfactory bulb axon guidance
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0R4J1E1
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:21752992
      assigned_by: MGI
    - protein: UniProtKB:Q99PV8
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:21752992
      assigned_by: MGI
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0071678
  - go_id: GO:0046534
    label: positive regulation of photoreceptor cell differentiation
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O54751
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9WTQ9|ensembl:ENSRNOP00000018858
    - protein: UniProtKB:Q62226
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:3673
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0046534
  - go_id: GO:0006109
    label: regulation of carbohydrate metabolic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 2
      Invertebrates: 4
    rate_ratio: 0.0564
    p_value: 0.00268
    q_value: 0.0117
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q60641
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:628831
    - protein: UniProtKB:Q9JLN9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:68371
      gene_review: genes/mouse/Mtor/Mtor-ai-review.yaml
  - go_id: GO:0071560
    label: cellular response to transforming growth factor beta stimulus
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 311
      Invertebrates: 2
    rate_ratio: 0.057
    p_value: 3.82e-12
    q_value: 6.69e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O97102
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:18794353
      assigned_by: FlyBase
      with_from: FB:FBgn0000490
    - protein: UniProtKB:Q7KNM2
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:18794353
      assigned_by: FlyBase
      with_from: FB:FBgn0000490
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0071560
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0071560
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0071560
  - go_id: GO:0034097
    label: response to cytokine
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 304
      Invertebrates: 2
    rate_ratio: 0.0583
    p_value: 7.73e-12
    q_value: 1.32e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P15330
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000652441|RGD:727889|UniProtKB:Q04206
      gene_review: genes/DROME/dl__P15330/dl__P15330-ai-review.yaml
    - protein: UniProtKB:P98149
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000652441|RGD:727889|UniProtKB:Q04206
      gene_review: genes/DROME/Dif/Dif-ai-review.yaml
  - go_id: GO:0098974
    label: postsynaptic actin cytoskeleton organization
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 150
      Invertebrates: 1
    rate_ratio: 0.0591
    p_value: 3.5e-06
    q_value: 2.88e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8SXX4
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:O75052
  - go_id: GO:1990138
    label: neuron projection extension
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 150
      Invertebrates: 1
    rate_ratio: 0.0591
    p_value: 3.5e-06
    q_value: 2.88e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09276
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:32665354
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:1990138
  - go_id: GO:0099175
    label: regulation of postsynapse organization
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 299
      Invertebrates: 2
    rate_ratio: 0.0593
    p_value: 1.28e-11
    q_value: 2.13e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O18333
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:28455372
      assigned_by: FlyBase
    - protein: UniProtKB:X2JDZ1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:28455372
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0099175
  - go_id: GO:0048156
    label: tau protein binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 149
      Invertebrates: 1
    rate_ratio: 0.0595
    p_value: 3.87e-06
    q_value: 3.17e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P23678
      taxon: NCBITaxon:6239
      evidence: IPI
      reference: PMID:21569846
      assigned_by: WB
      with_from: WB:WBGene00004212
  - go_id: GO:0019838
    label: growth factor binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 148
      Invertebrates: 1
    rate_ratio: 0.0599
    p_value: 4.28e-06
    q_value: 3.48e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q18530
      taxon: NCBITaxon:6239
      evidence: IPI
      reference: PMID:17240342
      assigned_by: WB
      with_from: UniProtKB:P12643
      gene_review: genes/worm/lon-2/lon-2-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0019838
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0019838
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0019838
  - go_id: GO:0050680
    label: negative regulation of epithelial cell proliferation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 294
      Invertebrates: 2
    rate_ratio: 0.0603
    p_value: 2.11e-11
    q_value: 3.48e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7JXV9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16256743
      assigned_by: FlyBase
    - protein: UniProtKB:Q7JXV9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16256745
      assigned_by: FlyBase
    - protein: UniProtKB:Q7KRY7
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:15611336
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0050680
  - go_id: GO:0030291
    label: protein serine/threonine kinase inhibitor activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 147
      Invertebrates: 1
    rate_ratio: 0.0603
    p_value: 4.73e-06
    q_value: 3.81e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V3Z1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:40292740
      assigned_by: FlyBase
  - go_id: GO:0043240
    label: Fanconi anaemia nuclear complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 288
      Invertebrates: 2
    rate_ratio: 0.0615
    p_value: 3.85e-11
    q_value: 6.08e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q20071
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008623726|UniProtKB:A8MT69
    - protein: UniProtKB:Q8T913
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR026848
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0043240
  - go_id: GO:0032481
    label: positive regulation of type I interferon production
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 286
      Invertebrates: 2
    rate_ratio: 0.062
    p_value: 4.71e-11
    q_value: 7.37e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4LFY9
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR029158
      gene_review: genes/DROME/Sting/Sting-ai-review.yaml
    - protein: UniProtKB:Q9V3Y8
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1929658|PANTHER:PTN000540338|UniProtKB:Q14164|UniProtKB:Q9UHD2
      gene_review: genes/DROME/IKKepsilon/IKKepsilon-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0032481
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0032481
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0032481
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0032481
  - go_id: GO:0008385
    label: IkappaB kinase complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 143
      Invertebrates: 1
    rate_ratio: 0.062
    p_value: 7.07e-06
    q_value: 5.48e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VEZ5
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1338071|MGI:MGI:99484|PANTHER:PTN000540281|RGD:1306661|RGD:621375|UniProtKB:O14920|UniProtKB:O15111
      gene_review: genes/DROME/IKKbeta/IKKbeta-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0008385
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0008385
  - go_id: GO:0006470
    label: protein dephosphorylation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 283
      Invertebrates: 2
    rate_ratio: 0.0626
    p_value: 6.36e-11
    q_value: 9.81e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EGJ9
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:28135265
      assigned_by: UniProt
    - protein: UniProtKB:Q6NN85
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:11832213
      assigned_by: UniProt
    - protein: UniProtKB:Q6NN85
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:15572110
      assigned_by: UniProt
  - go_id: GO:0043149
    label: stress fiber assembly
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 141
      Invertebrates: 1
    rate_ratio: 0.0628
    p_value: 8.65e-06
    q_value: 6.62e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P49455
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:27396338
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0043149
  - go_id: GO:0061028
    label: establishment of endothelial barrier
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 140
      Invertebrates: 1
    rate_ratio: 0.0633
    p_value: 9.56e-06
    q_value: 7.25e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O46101
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:26848177
      assigned_by: UniProt
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0061028
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0061028
  - go_id: GO:2000179
    label: positive regulation of neural precursor cell proliferation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 139
      Invertebrates: 1
    rate_ratio: 0.0637
    p_value: 1.06e-05
    q_value: 7.91e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W4B2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18723351
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:2000179
  - go_id: GO:0070301
    label: cellular response to hydrogen peroxide
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 278
      Invertebrates: 2
    rate_ratio: 0.0637
    p_value: 1.05e-10
    q_value: 1.59e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0K3AUJ9
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20649472
      assigned_by: UniProt
    - protein: UniProtKB:P54137
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:19481506
      assigned_by: WB
      with_from: UniProtKB:P0AB83|UniProtKB:P50465
  - go_id: GO:0043473
    label: pigmentation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 138
      Invertebrates: 1
    rate_ratio: 0.0642
    p_value: 1.17e-05
    q_value: 8.69e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W060
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107448|PANTHER:PTN009012663|RGD:15011516|UniProtKB:Q99698
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0043473
  - go_id: GO:0004629
    label: C-type glycerophospholipase activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 137
      Invertebrates: 1
    rate_ratio: 0.0647
    p_value: 1.29e-05
    q_value: 9.49e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P13217
      taxon: NCBITaxon:7227
      evidence: TAS
      reference: PMID:10611962
      assigned_by: FlyBase
      gene_review: genes/DROME/norpA/norpA-ai-review.yaml
  - go_id: GO:2000379
    label: positive regulation of reactive oxygen species metabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 137
      Invertebrates: 1
    rate_ratio: 0.0647
    p_value: 1.29e-05
    q_value: 9.49e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8MUJ1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22065747
      assigned_by: FlyBase
  - go_id: GO:0010977
    label: negative regulation of neuron projection development
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 408
      Invertebrates: 3
    rate_ratio: 0.0651
    p_value: 2.87e-15
    q_value: 6.78e-14
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P00522
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:24466097
      assigned_by: CACAO
    - protein: UniProtKB:P08155
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:17562531
      assigned_by: FlyBase
      with_from: FB:FBgn0011300
    - protein: UniProtKB:Q22354
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:22363657
      assigned_by: WB
      gene_review: genes/worm/rhgf-2/rhgf-2-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0010977
  - go_id: GO:0097192
    label: extrinsic apoptotic signaling pathway in absence of ligand
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 135
      Invertebrates: 1
    rate_ratio: 0.0656
    p_value: 1.58e-05
    q_value: 0.000114
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P41958
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:101769|MGI:MGI:108052|MGI:MGI:1097161|MGI:MGI:88138|MGI:MGI:88139|MGI:MGI:99702|PANTHER:PTN000135648|UniProtKB:Q07820
      gene_review: genes/worm/ced-9/ced-9-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0097192
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0097192
  - go_id: GO:0007162
    label: negative regulation of cell adhesion
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 268
      Invertebrates: 2
    rate_ratio: 0.0661
    p_value: 2.85e-10
    q_value: 4.09e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O45657
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001861955|UniProtKB:O43157|UniProtKB:Q9ULL4
    - protein: UniProtKB:Q9V4A7
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001861955|UniProtKB:O43157|UniProtKB:Q9ULL4
  - go_id: GO:0042573
    label: retinoic acid metabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 133
      Invertebrates: 1
    rate_ratio: 0.0666
    p_value: 1.93e-05
    q_value: 0.000137
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VB96
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00049831
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4895 (Schizosaccharomyces), on GO:0042573
  - go_id: GO:1901224
    label: positive regulation of non-canonical NF-kappaB signal transduction
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 265
      Invertebrates: 2
    rate_ratio: 0.0669
    p_value: 3.84e-10
    q_value: 5.46e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9NA71
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1344372|PANTHER:PTN000511633
    - protein: UniProtKB:Q9V3Q6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:14519762
      assigned_by: UniProt
  - go_id: GO:0001836
    label: release of cytochrome c from mitochondria
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 132
      Invertebrates: 1
    rate_ratio: 0.0671
    p_value: 2.13e-05
    q_value: 0.00015
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P41958
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1097161|MGI:MGI:88138|MGI:MGI:88139|MGI:MGI:99702|PANTHER:PTN000135648|RGD:2192|RGD:621635|UniProtKB:Q07812|UniProtKB:Q07817|UniProtKB:Q16611|UniProtKB:Q9UMX3
      gene_review: genes/worm/ced-9/ced-9-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0001836
    - only_in_taxon NCBITaxon:33154 (Opisthokonta), on GO:0001836
  - go_id: GO:0043198
    label: dendritic shaft
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 395
      Invertebrates: 3
    rate_ratio: 0.0673
    p_value: 1.05e-14
    q_value: 2.36e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4KH16
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26216903
      assigned_by: FlyBase
    - protein: UniProtKB:A0A0B4KHT3
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26216903
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VDJ9
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26216903
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0043198
  - go_id: GO:0006217
    label: deoxycytidine catabolic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 5
    rate_ratio: 0.0677
    p_value: 0.000923
    q_value: 0.00452
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZG12
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000182087|SGD:S000004235|UniProtKB:P0ABF6|WB:WBGene00000391|WB:WBGene00000392
    - protein: UniProtKB:P32320
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000182087|SGD:S000004235|UniProtKB:P0ABF6|WB:WBGene00000391|WB:WBGene00000392
      gene_review: genes/human/CDA/CDA-ai-review.yaml
    - protein: UniProtKB:P56389
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000182087|SGD:S000004235|UniProtKB:P0ABF6|WB:WBGene00000391|WB:WBGene00000392
  - go_id: GO:0046109
    label: uridine biosynthetic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 5
    rate_ratio: 0.0677
    p_value: 0.000923
    q_value: 0.00452
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZG12
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000182087|UniProtKB:P9WPH3|WB:WBGene00000391|WB:WBGene00000392
    - protein: UniProtKB:P32320
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000182087|UniProtKB:P9WPH3|WB:WBGene00000391|WB:WBGene00000392
      gene_review: genes/human/CDA/CDA-ai-review.yaml
    - protein: UniProtKB:P56389
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000182087|UniProtKB:P9WPH3|WB:WBGene00000391|WB:WBGene00000392
  - go_id: GO:1990386
    label: mitotic cleavage furrow ingression
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 5
    rate_ratio: 0.0677
    p_value: 0.000923
    q_value: 0.00452
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V1A061
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P84078|ensembl:ENSMUSP00000079905
    - protein: UniProtKB:P84077
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P84078|ensembl:ENSMUSP00000079905
      gene_review: genes/human/ARF1/ARF1-ai-review.yaml
    - protein: UniProtKB:P84078
      taxon: NCBITaxon:10090
      evidence: IGI
      reference: PMID:27535433
      assigned_by: UniProt
      with_from: UniProtKB:P61209
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1990386
  - go_id: GO:0007630
    label: jump response
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 5
    rate_ratio: 0.0677
    p_value: 0.000923
    q_value: 0.00452
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6VE93
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:621118
    - protein: UniProtKB:Q69ZK9
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q62888|ensembl:ENSRNOP00000053713
    - protein: UniProtKB:Q69ZK9
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:621118
    - protein: UniProtKB:Q69ZK9
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: BHF-UCL
      with_from: UniProtKB:Q62888
    - protein: UniProtKB:Q8NFZ4
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q62888|ensembl:ENSRNOP00000053713
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0007630
  - go_id: GO:0180029
    label: phosphate ion export across plasma membrane
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 5
    rate_ratio: 0.0677
    p_value: 0.000923
    q_value: 0.00452
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Y578
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000081885|PomBase:SPCC1827.07c
    - protein: UniProtKB:Q9UBH6
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000081885|PomBase:SPCC1827.07c
    - protein: UniProtKB:Q9Z0U0
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000081885|PomBase:SPCC1827.07c
  - go_id: GO:0030137
    label: COPI-coated vesicle
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 129
      Invertebrates: 1
    rate_ratio: 0.0687
    p_value: 2.87e-05
    q_value: 0.000198
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9W0B8
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00085922
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0030137
  - go_id: GO:0050679
    label: positive regulation of epithelial cell proliferation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 387
      Invertebrates: 3
    rate_ratio: 0.0687
    p_value: 2.33e-14
    q_value: 5.01e-13
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P04412
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:95294|PANTHER:PTN000698827|RGD:620486|UniProtKB:P00533|UniProtKB:P04626
      gene_review: genes/DROME/Egfr/Egfr-ai-review.yaml
    - protein: UniProtKB:P10038
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:8625851
      assigned_by: WB
      with_from: WB:WBVar00143853
    - protein: UniProtKB:P24348
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:95294|PANTHER:PTN000698827|RGD:620486|UniProtKB:P00533|UniProtKB:P04626
      gene_review: genes/worm/let-23/let-23-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0050679
  - go_id: GO:0048384
    label: retinoic acid receptor signaling pathway
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 129
      Invertebrates: 1
    rate_ratio: 0.0687
    p_value: 2.87e-05
    q_value: 0.000198
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P20153
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:98214|MGI:MGI:98215|MGI:MGI:98216|PANTHER:PTN002786703|UniProtKB:P19793
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0048384
  - go_id: GO:0019208
    label: phosphatase regulator activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 129
      Invertebrates: 1
    rate_ratio: 0.0687
    p_value: 2.87e-05
    q_value: 0.000198
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P23696
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:18256265
      assigned_by: FlyBase
      gene_review: genes/DROME/mts/mts-ai-review.yaml
  - go_id: GO:0043274
    label: phospholipase binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 126
      Invertebrates: 1
    rate_ratio: 0.0703
    p_value: 3.87e-05
    q_value: 0.000261
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P22981
      taxon: NCBITaxon:6239
      evidence: IPI
      reference: PMID:9497345
      assigned_by: WB
      with_from: UniProtKB:G5EFI8
      gene_review: genes/worm/let-60/let-60-ai-review.yaml
  - go_id: GO:1902018
    label: negative regulation of cilium assembly
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 126
      Invertebrates: 1
    rate_ratio: 0.0703
    p_value: 3.87e-05
    q_value: 0.000261
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VQV7
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1921451|PANTHER:PTN000062961|UniProtKB:Q8IW35
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:1902018
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:1902018
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:1902018
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:1902018
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:1902018
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:1902018
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:1902018
  - go_id: GO:0015213
    label: uridine transmembrane transporter activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 125
      Invertebrates: 1
    rate_ratio: 0.0709
    p_value: 4.28e-05
    q_value: 0.000286
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V492
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:37810222
      assigned_by: FlyBase
  - go_id: GO:0015862
    label: uridine transmembrane transport
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 125
      Invertebrates: 1
    rate_ratio: 0.0709
    p_value: 4.28e-05
    q_value: 0.000286
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V492
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:37810222
      assigned_by: FlyBase
  - go_id: GO:0061744
    label: motor behavior
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 125
      Invertebrates: 1
    rate_ratio: 0.0709
    p_value: 4.28e-05
    q_value: 0.000286
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VYV9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:28949413
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0061744
  - go_id: GO:0099072
    label: regulation of postsynaptic membrane neurotransmitter receptor levels
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 249
      Invertebrates: 2
    rate_ratio: 0.0712
    p_value: 1.89e-09
    q_value: 2.5e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5ECY0
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107231|MGI:MGI:1277959|MGI:MGI:1344351|MGI:MGI:1888986|PANTHER:PTN000563569|RGD:2505|RGD:68423
    - protein: UniProtKB:P31007
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107231|MGI:MGI:1277959|MGI:MGI:1344351|MGI:MGI:1888986|PANTHER:PTN000563569|RGD:2505|RGD:68423
      gene_review: genes/DROME/dlg1/dlg1-ai-review.yaml
  - go_id: GO:0051219
    label: phosphoprotein binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 248
      Invertebrates: 2
    rate_ratio: 0.0714
    p_value: 2.08e-09
    q_value: 2.74e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4KHK1
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:16326393
      assigned_by: FlyBase
      with_from: FB:FBgn0004859
      gene_review: genes/DROME/slmb/slmb-ai-review.yaml
    - protein: UniProtKB:Q9VYD1
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:17560546
      assigned_by: FlyBase
      with_from: FB:FBgn0003277
  - go_id: GO:0001933
    label: negative regulation of protein phosphorylation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 248
      Invertebrates: 2
    rate_ratio: 0.0714
    p_value: 2.08e-09
    q_value: 2.74e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q10038
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:22554143
      assigned_by: UniProt
    - protein: UniProtKB:Q94131
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:18202370
      assigned_by: UniProt
  - go_id: GO:0001523
    label: retinoid metabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 123
      Invertebrates: 1
    rate_ratio: 0.072
    p_value: 5.22e-05
    q_value: 0.00034
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VGP2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:15640158
      assigned_by: UniProt
    - protein: UniProtKB:Q9VGP2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16464863
      assigned_by: UniProt
  - go_id: GO:0160111
    label: axonemal A tubule inner sheath
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 123
      Invertebrates: 1
    rate_ratio: 0.072
    p_value: 5.22e-05
    q_value: 0.00034
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7JRP4
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:A2AIP0
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0160111
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0160111
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0160111
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0160111
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0160111
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0160111
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0160111
  - go_id: GO:0051591
    label: response to cAMP
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 123
      Invertebrates: 1
    rate_ratio: 0.072
    p_value: 5.22e-05
    q_value: 0.00034
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VQH2
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9NRD8
  - go_id: GO:0043507
    label: positive regulation of JUN kinase activity
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 122
      Invertebrates: 1
    rate_ratio: 0.0726
    p_value: 5.77e-05
    q_value: 0.00037
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9NCS6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:37138087
      assigned_by: UniProt
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0043507
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0043507
  - go_id: GO:0071364
    label: cellular response to epidermal growth factor stimulus
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 242
      Invertebrates: 2
    rate_ratio: 0.0732
    p_value: 3.78e-09
    q_value: 4.75e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VZI2
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22615583
      assigned_by: UniProt
    - protein: UniProtKB:Q9W379
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:O75312
      gene_review: genes/DROME/Zpr1/Zpr1-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0071364
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0071364
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0071364
  - go_id: GO:0140900
    label: chloride:bicarbonate antiporter activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 120
      Invertebrates: 1
    rate_ratio: 0.0738
    p_value: 7.03e-05
    q_value: 0.000444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VT48
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:109350|MGI:MGI:109351|MGI:MGI:109393|PANTHER:PTN002479121|RGD:3711|RGD:3712|UniProtKB:P02730|UniProtKB:P04920|UniProtKB:P48751|ZFIN:ZDB-GENE-030429-14|ZFIN:ZDB-GENE-051101-2
  - go_id: GO:0033173
    label: calcineurin-NFAT signaling cascade
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 120
      Invertebrates: 1
    rate_ratio: 0.0738
    p_value: 7.03e-05
    q_value: 0.000444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VVM7
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P63098
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0033173
  - go_id: GO:0032691
    label: negative regulation of interleukin-1 beta production
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 120
      Invertebrates: 1
    rate_ratio: 0.0738
    p_value: 7.03e-05
    q_value: 0.000444
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8MLW4
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00086217
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0032691
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0032691
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0032691
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0032691
  - go_id: GO:0048306
    label: calcium-dependent protein binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 355
      Invertebrates: 3
    rate_ratio: 0.0749
    p_value: 5.54e-13
    q_value: 1.05e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KV26
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17284449
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VYE6
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17284449
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VYE7
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17284449
      assigned_by: FlyBase
  - go_id: GO:0009896
    label: positive regulation of catabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 118
      Invertebrates: 1
    rate_ratio: 0.0751
    p_value: 8.58e-05
    q_value: 0.000531
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KTX7
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00028093
      gene_review: genes/DROME/park/park-ai-review.yaml
  - go_id: GO:0045600
    label: positive regulation of fat cell differentiation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 236
      Invertebrates: 2
    rate_ratio: 0.0751
    p_value: 6.84e-09
    q_value: 8.34e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A2K5ATM8
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1914293|PANTHER:PTN000410824|UniProtKB:Q96A49
    - protein: UniProtKB:Q960T2
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1914293|PANTHER:PTN000410824|UniProtKB:Q96A49
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0045600
  - go_id: GO:0099171
    label: presynaptic modulation of chemical synaptic transmission
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 234
      Invertebrates: 2
    rate_ratio: 0.0757
    p_value: 8.33e-09
    q_value: 1.01e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A8JQY3
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:32973097
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VDH5
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:32973097
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0099171
  - go_id: GO:0098708
    label: D-glucose import across plasma membrane
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 117
      Invertebrates: 1
    rate_ratio: 0.0757
    p_value: 9.47e-05
    q_value: 0.000584
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V9U1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:34830305
      assigned_by: FlyBase
  - go_id: GO:0002080
    label: acrosomal membrane
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 116
      Invertebrates: 1
    rate_ratio: 0.0764
    p_value: 0.000105
    q_value: 0.000641
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VU52
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0006
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0002080
  - go_id: GO:2000637
    label: positive regulation of miRNA-mediated gene silencing
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 230
      Invertebrates: 2
    rate_ratio: 0.077
    p_value: 1.24e-08
    q_value: 1.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1ZAP7
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:33693718
      assigned_by: FlyBase
    - protein: UniProtKB:Q8IMX4
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:33203680
      assigned_by: FlyBase
      with_from: FB:FBgn0262432
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:2000637
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:2000637
  - go_id: GO:0070830
    label: bicellular tight junction assembly
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 230
      Invertebrates: 2
    rate_ratio: 0.077
    p_value: 1.24e-08
    q_value: 1.46e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q19493
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000974682|UniProtKB:Q28205
    - protein: UniProtKB:Q9VQ78
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000974682|UniProtKB:Q28205
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0070830
  - go_id: GO:0051393
    label: alpha-actinin binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 115
      Invertebrates: 1
    rate_ratio: 0.077
    p_value: 0.000115
    q_value: 0.0007
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VV74
      taxon: NCBITaxon:7227
      evidence: IPI
      reference: PMID:17353360
      assigned_by: FlyBase
      with_from: FB:FBgn0000667
      gene_review: genes/DROME/Smn/Smn-ai-review.yaml
  - go_id: GO:0042755
    label: eating behavior
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 115
      Invertebrates: 1
    rate_ratio: 0.077
    p_value: 0.000115
    q_value: 0.0007
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q21578
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:15282157
      assigned_by: WB
      with_from: WB:WBVar00000017
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0042755
  - go_id: GO:1990166
    label: protein localization to site of double-strand break
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 115
      Invertebrates: 1
    rate_ratio: 0.077
    p_value: 0.000115
    q_value: 0.0007
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9BL57
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000401295|UniProtKB:O43719
  - go_id: GO:0050890
    label: cognition
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 341
      Invertebrates: 3
    rate_ratio: 0.0779
    p_value: 2.2e-12
    q_value: 3.96e-11
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z6K5
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q96NR3
    - protein: UniProtKB:P18459
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:98735|PANTHER:PTN000158532|RGD:3853|WB:WBGene00000296
    - protein: UniProtKB:P90986
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:98735|PANTHER:PTN000158532|RGD:3853|WB:WBGene00000296
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0050890
  - go_id: GO:0001867
    label: complement activation, lectin pathway
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 113
      Invertebrates: 1
    rate_ratio: 0.0784
    p_value: 0.000141
    q_value: 0.000828
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:B7Z0B9
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:96923|MGI:MGI:96924|PANTHER:PTN001167206|RGD:3055|UniProtKB:P11226|UniProtKB:Q9BWP8|UniProtKB:Q9Y6Z7
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0001867
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0001867
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0001867
  - go_id: GO:0035253
    label: ciliary rootlet
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 226
      Invertebrates: 2
    rate_ratio: 0.0784
    p_value: 1.83e-08
    q_value: 2.09e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VCD1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:17875208
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VCD1
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:26483560
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VTQ3
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: FB:FBgn0036219|PANTHER:PTN001093369
    - protein: UniProtKB:Q9VTQ3
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:24067530
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:3176 (Zygnematales), on GO:0035253
    - never_in_taxon NCBITaxon:3378 (Gnetales), on GO:0035253
    - never_in_taxon NCBITaxon:3398 (Magnoliopsida), on GO:0035253
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0035253
    - never_in_taxon NCBITaxon:5782 (Dictyostelium), on GO:0035253
    - never_in_taxon NCBITaxon:58019 (Pinopsida), on GO:0035253
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0035253
  - go_id: GO:0097696
    label: cell surface receptor signaling pathway via STAT
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 112
      Invertebrates: 1
    rate_ratio: 0.0791
    p_value: 0.000155
    q_value: 0.000908
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q24151
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:36817462
      assigned_by: FlyBase
  - go_id: GO:0010634
    label: positive regulation of epithelial cell migration
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 222
      Invertebrates: 2
    rate_ratio: 0.0798
    p_value: 2.72e-08
    q_value: 3.01e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q22070
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000741536|RGD:3347|UniProtKB:P19174
    - protein: UniProtKB:Q9VXH3
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000741536|RGD:3347|UniProtKB:P19174
    - protein: UniProtKB:Q9VXH3
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000104
      assigned_by: UniProt
      with_from: UniRule:UR000925796
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0010634
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0010634
    - never_in_taxon NCBITaxon:451864 (Dikarya), on GO:0010634
  - go_id: GO:0006855
    label: xenobiotic transmembrane transport
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 111
      Invertebrates: 1
    rate_ratio: 0.0798
    p_value: 0.000171
    q_value: 0.000998
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q00449
      taxon: NCBITaxon:7227
      evidence: NAS
      reference: PMID:2072901
      assigned_by: UniProt
  - go_id: GO:0160064
    label: multi-pass translocon complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 110
      Invertebrates: 1
    rate_ratio: 0.0805
    p_value: 0.000189
    q_value: 0.00109
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z843
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000117
      assigned_by: UniProt
      with_from: ARBA:ARBA00088300
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0160064
  - go_id: GO:0141163
    label: positive regulation of cAMP/PKA signal transduction
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 110
      Invertebrates: 1
    rate_ratio: 0.0805
    p_value: 0.000189
    q_value: 0.00109
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VHI7
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN008560982|RGD:620273|UniProtKB:O43164
  - go_id: GO:0070886
    label: positive regulation of calcineurin-NFAT signaling cascade
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 108
      Invertebrates: 1
    rate_ratio: 0.082
    p_value: 0.00023
    q_value: 0.0013
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9U6B8
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16582901
      assigned_by: UniProt
      gene_review: genes/DROME/Orai/Orai-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0070886
  - go_id: GO:0019233
    label: sensory perception of pain
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 215
      Invertebrates: 2
    rate_ratio: 0.0824
    p_value: 5.41e-08
    q_value: 5.78e-07
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P35500
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107636|MGI:MGI:108029|MGI:MGI:1345149|MGI:MGI:98246|PANTHER:PTN000004282
    - protein: UniProtKB:Q9W0Y6
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:12705873
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0019233
  - go_id: GO:0043647
    label: inositol phosphate metabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 107
      Invertebrates: 1
    rate_ratio: 0.0828
    p_value: 0.000254
    q_value: 0.00142
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:E2QCV9
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:20394834
      assigned_by: FlyBase
  - go_id: GO:0023019
    label: signal transduction involved in regulation of gene expression
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 105
      Invertebrates: 1
    rate_ratio: 0.0844
    p_value: 0.000309
    q_value: 0.00171
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q22227
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:19298786
      assigned_by: WB
      with_from: WB:WBGene00001102
  - go_id: GO:0051592
    label: response to calcium ion
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 314
      Invertebrates: 3
    rate_ratio: 0.0846
    p_value: 3.12e-11
    q_value: 4.96e-10
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EC26
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:15670846
      assigned_by: WB
    - protein: UniProtKB:G5EDU1
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:15670846
      assigned_by: WB
    - protein: UniProtKB:Q9VXG4
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:P50995
  - go_id: GO:0006769
    label: nicotinamide metabolic process
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D3YX59
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P40261
    - protein: UniProtKB:O55239
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:26168293
      assigned_by: UniProt
    - protein: UniProtKB:O55239
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:P40261|ensembl:ENSP00000299964
    - protein: UniProtKB:O55239
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:P40261
    - protein: UniProtKB:P40261
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:21823666
      assigned_by: UniProt
    - protein: UniProtKB:P40261
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:8182091
      assigned_by: UniProt
    - protein: UniProtKB:P40261
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:O55239|ensembl:ENSMUSP00000034808
  - go_id: GO:0071261
    label: Ssh1 translocon complex
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0XST0
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000267681|SGD:S000002493
    - protein: UniProtKB:P60059
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000267681|SGD:S000002493
      gene_review: genes/human/SEC61G/SEC61G-ai-review.yaml
    - protein: UniProtKB:P60060
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000267681|SGD:S000002493
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071261
  - go_id: GO:0008455
    label: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZJD2
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G05320|FB:FBgn0039738|MGI:MGI:2384966|PANTHER:PTN000305532|RGD:620098|UniProtKB:Q10469
    - protein: UniProtKB:A0A8V0ZJD2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007754
    - protein: UniProtKB:A0A8V0ZJD2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.1.143|EC:2.4.1.143
    - protein: UniProtKB:A0A8V0ZJD2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q10469|ensembl:ENSP00000307423
    - protein: UniProtKB:A0A8V0ZJD2
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q921V5|ensembl:ENSMUSP00000057905
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: EXP
      reference: PMID:36280670
      assigned_by: UniProt
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G05320|FB:FBgn0039738|MGI:MGI:2384966|PANTHER:PTN000305532|RGD:620098|UniProtKB:Q10469
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:29666272
      assigned_by: UniProt
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:7635144
      assigned_by: UniProt
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007754
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.1.143
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q921V5|ensembl:ENSMUSP00000057905
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12941
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:8808595
      assigned_by: UniProt
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-4793955
      assigned_by: Reactome
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-9694656
      assigned_by: Reactome
    - protein: UniProtKB:Q10469
      taxon: NCBITaxon:9606
      evidence: TAS
      reference: Reactome:R-HSA-975829
      assigned_by: Reactome
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: AGI_LocusCode:AT2G05320|FB:FBgn0039738|MGI:MGI:2384966|PANTHER:PTN000305532|RGD:620098|UniProtKB:Q10469
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR007754
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000003
      assigned_by: UniProt
      with_from: EC:2.4.1.143
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q10469|ensembl:ENSP00000307423
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000116
      assigned_by: RHEA
      with_from: RHEA:12941
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:12417412
      assigned_by: MGI
      with_from: MGI:MGI:2667740
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:620098
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q10469
    - protein: UniProtKB:Q921V5
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q10469
  - go_id: GO:0016427
    label: tRNA (cytidine) methyltransferase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q5ZHP8
      taxon: NCBITaxon:9031
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q6P1Q9
    - protein: UniProtKB:Q6P1Q9
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:21518805
      assigned_by: UniProt
    - protein: UniProtKB:Q8BMK1
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q6P1Q9
    - protein: UniProtKB:Q8BMK1
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q6P1Q9
  - go_id: GO:0160215
    label: deacylase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YFX7
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000398233|RGD:1303213|UniProtKB:Q75T13
    - protein: UniProtKB:A0A8V0YFX7
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q75T13|ensembl:ENSP00000346809
    - protein: UniProtKB:Q3UUQ7
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000398233|RGD:1303213|UniProtKB:Q75T13
    - protein: UniProtKB:Q3UUQ7
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q75T13|ensembl:ENSP00000346809
    - protein: UniProtKB:Q3UUQ7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000096
      assigned_by: GO_Central
      with_from: RGD:1303213
    - protein: UniProtKB:Q3UUQ7
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q75T13
    - protein: UniProtKB:Q3UUQ7
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q75T13
    - protein: UniProtKB:Q3UUQ7
      taxon: NCBITaxon:10090
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q765A7
    - protein: UniProtKB:Q75T13
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000398233|RGD:1303213|UniProtKB:Q75T13
      gene_review: genes/human/PGAP1/PGAP1-ai-review.yaml
    - protein: UniProtKB:Q75T13
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:24784135
      assigned_by: UniProt
      gene_review: genes/human/PGAP1/PGAP1-ai-review.yaml
    - protein: UniProtKB:Q75T13
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:38167496
      assigned_by: UniProt
      gene_review: genes/human/PGAP1/PGAP1-ai-review.yaml
  - go_id: GO:0008579
    label: JUN kinase phosphatase activity
    aspect: MF
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:F6TWS0
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:11959861
      assigned_by: MGI
    - protein: UniProtKB:Q8K4T5
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1915332|PANTHER:PTN002923848
    - protein: UniProtKB:Q8K4T5
      taxon: NCBITaxon:10090
      evidence: IDA
      reference: PMID:11959861
      assigned_by: MGI
    - protein: UniProtKB:Q8WTR2
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1915332|PANTHER:PTN002923848
  - go_id: GO:0141065
    label: maternal mRNA clearance
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0ZRX9
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8CGC4|ensembl:ENSMUSP00000055036
    - protein: UniProtKB:Q8CGC4
      taxon: NCBITaxon:10090
      evidence: IMP
      reference: PMID:37889087
      assigned_by: UniProt
    - protein: UniProtKB:Q9BX40
      taxon: NCBITaxon:9606
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q8CGC4|ensembl:ENSMUSP00000055036
    - protein: UniProtKB:Q9BX40
      taxon: NCBITaxon:9606
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q8CGC4
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0141065
  - go_id: GO:0031207
    label: Sec62/Sec63 complex
    aspect: CC
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0YP44
      taxon: NCBITaxon:9031
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000636458|SGD:S000005780
    - protein: UniProtKB:Q8VHE0
      taxon: NCBITaxon:10090
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000636458|SGD:S000005780
    - protein: UniProtKB:Q9UGP8
      taxon: NCBITaxon:9606
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN000636458|SGD:S000005780
      gene_review: genes/human/SEC63/SEC63-ai-review.yaml
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0031207
  - go_id: GO:0090625
    label: siRNA-mediated gene silencing by mRNA destabilization
    aspect: BP
    flagged_taxon: Vertebrates
    highest_taxon: Invertebrates
    annotated_protein_counts:
      Vertebrates: 3
      Invertebrates: 4
    rate_ratio: 0.0847
    p_value: 0.00575
    q_value: 0.0226
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A8V0Y222
      taxon: NCBITaxon:9031
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9UKV8|ensembl:ENSP00000220592
    - protein: UniProtKB:Q8CJG0
      taxon: NCBITaxon:10090
      evidence: IEA
      reference: GO_REF:0000107
      assigned_by: Ensembl
      with_from: UniProtKB:Q9UKV8|ensembl:ENSP00000220592
    - protein: UniProtKB:Q8CJG0
      taxon: NCBITaxon:10090
      evidence: ISO
      reference: GO_REF:0000119
      assigned_by: GO_Central
      with_from: UniProtKB:Q9UKV8
    - protein: UniProtKB:Q9UKV8
      taxon: NCBITaxon:9606
      evidence: IDA
      reference: PMID:15260970
      assigned_by: BHF-UCL
      gene_review: genes/human/AGO2/AGO2-ai-review.yaml
    - protein: UniProtKB:Q9UKV8
      taxon: NCBITaxon:9606
      evidence: IMP
      reference: PMID:22795694
      assigned_by: BHF-UCL
      gene_review: genes/human/AGO2/AGO2-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0090625
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0090625
  - go_id: GO:0071005
    label: U2-type precatalytic spliceosome
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 209
      Invertebrates: 2
    rate_ratio: 0.0848
    p_value: 9.73e-08
    q_value: 1.01e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EEG7
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q2TAY7
    - protein: UniProtKB:Q19952
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q9Y4Z0
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:2759 (Eukaryota), on GO:0071005
  - go_id: GO:0030214
    label: hyaluronan catabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 104
      Invertebrates: 1
    rate_ratio: 0.0852
    p_value: 0.000341
    q_value: 0.00185
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5ECE8
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1196334|MGI:MGI:1330288|MGI:MGI:96298|PANTHER:PTN000924992|RGD:620321|UniProtKB:F1MZM9|UniProtKB:O43820|UniProtKB:Q12794|UniProtKB:Q12891
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0030214
    - never_in_taxon NCBITaxon:6656 (Arthropoda), on GO:0030214
  - go_id: GO:0019209
    label: kinase activator activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 103
      Invertebrates: 1
    rate_ratio: 0.086
    p_value: 0.000377
    q_value: 0.00203
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VDE4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:32750048
      assigned_by: FlyBase
  - go_id: GO:0110053
    label: regulation of actin filament organization
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 102
      Invertebrates: 1
    rate_ratio: 0.0869
    p_value: 0.000415
    q_value: 0.0022
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7KVD1
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:22442703
      assigned_by: UniProt
  - go_id: GO:0150037
    label: regulation of calcium-dependent activation of synaptic vesicle fusion
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 102
      Invertebrates: 1
    rate_ratio: 0.0869
    p_value: 0.000415
    q_value: 0.0022
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4K7K9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:16614170
      assigned_by: UniProt
    - protein: UniProtKB:A0A0B4K7K9
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:23960145
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0150037
  - go_id: GO:0005164
    label: tumor necrosis factor receptor binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 203
      Invertebrates: 2
    rate_ratio: 0.0873
    p_value: 1.75e-07
    q_value: 1.76e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8MUJ1
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR006052
    - protein: UniProtKB:Q9W3I9
      taxon: NCBITaxon:7227
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR037309
  - go_id: GO:0060077
    label: inhibitory synapse
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 201
      Invertebrates: 2
    rate_ratio: 0.0882
    p_value: 2.13e-07
    q_value: 2.11e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q8I4D9
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:9880574
      assigned_by: WB
    - protein: UniProtKB:Q8I4E0
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:9880574
      assigned_by: WB
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0060077
  - go_id: GO:0030057
    label: desmosome
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 199
      Invertebrates: 2
    rate_ratio: 0.089
    p_value: 2.58e-07
    q_value: 2.52e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G8JY94
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:12204276
      assigned_by: WB
    - protein: UniProtKB:Q21067
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:12204276
      assigned_by: WB
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0030057
  - go_id: GO:0043542
    label: endothelial cell migration
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 199
      Invertebrates: 2
    rate_ratio: 0.089
    p_value: 2.58e-07
    q_value: 2.52e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VW85
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2652860|PANTHER:PTN001408592|ZFIN:ZDB-GENE-060503-766|ZFIN:ZDB-GENE-090908-6
    - protein: UniProtKB:S6EZU2
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:2652860|PANTHER:PTN001408592|ZFIN:ZDB-GENE-060503-766|ZFIN:ZDB-GENE-090908-6
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4890 (Ascomycota), on GO:0043542
  - go_id: GO:0060586
    label: multicellular organismal-level iron ion homeostasis
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 198
      Invertebrates: 2
    rate_ratio: 0.0895
    p_value: 2.85e-07
    q_value: 2.77e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VAF0
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:25006035
      assigned_by: FlyBase
    - protein: UniProtKB:Q9VAY3
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:25841783
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0060586
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0060586
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:0060586
    - never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae), on GO:0060586
  - go_id: GO:0045429
    label: positive regulation of nitric oxide biosynthetic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 196
      Invertebrates: 2
    rate_ratio: 0.0904
    p_value: 3.46e-07
    q_value: 3.33e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q94527
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19221590
      assigned_by: FlyBase
      gene_review: genes/DROME/Rel/Rel-ai-review.yaml
    - protein: UniProtKB:Q9VYF0
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:1916469|PANTHER:PTN000978164|RGD:70968|UniProtKB:P56965|UniProtKB:Q3SX44
  - go_id: GO:0030247
    label: polysaccharide binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 97
      Invertebrates: 1
    rate_ratio: 0.0913
    p_value: 0.000677
    q_value: 0.00342
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9V3H7
      taxon: NCBITaxon:7227
      evidence: TAS
      reference: PMID:10758400
      assigned_by: FlyBase
  - go_id: GO:0002102
    label: podosome
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 288
      Invertebrates: 3
    rate_ratio: 0.0923
    p_value: 3.91e-10
    q_value: 5.54e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A1Z714
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:21571220
      assigned_by: FlyBase
    - protein: UniProtKB:E1JGZ4
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:21571220
      assigned_by: FlyBase
    - protein: UniProtKB:Q09476
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:21633109
      assigned_by: WB
    - protein: UniProtKB:Q09476
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0295
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0002102
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0002102
  - go_id: GO:0005539
    label: glycosaminoglycan binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 96
      Invertebrates: 1
    rate_ratio: 0.0923
    p_value: 0.000747
    q_value: 0.00373
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P09615
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:8909553
      assigned_by: FlyBase
  - go_id: GO:7770015
    label: intermembrane lipid transporter complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 95
      Invertebrates: 1
    rate_ratio: 0.0933
    p_value: 0.000823
    q_value: 0.00408
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:A0A0B4JCZ0
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q9BZF1
  - go_id: GO:0032993
    label: protein-DNA complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 285
      Invertebrates: 3
    rate_ratio: 0.0933
    p_value: 5.23e-10
    q_value: 7.28e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:O46339
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:19481089
      assigned_by: CAFA
    - protein: UniProtKB:P40427
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:19481089
      assigned_by: CAFA
    - protein: UniProtKB:P83949
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18508761
      assigned_by: CAFA
    - protein: UniProtKB:P83949
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19481089
      assigned_by: CAFA
  - go_id: GO:0008542
    label: visual learning
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 283
      Invertebrates: 3
    rate_ratio: 0.0939
    p_value: 6.35e-10
    q_value: 8.78e-09
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P12982
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:8382739
      assigned_by: FlyBase
    - protein: UniProtKB:P25158
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19543525
      assigned_by: FlyBase
    - protein: UniProtKB:P41596
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:7953290
      assigned_by: UniProt
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33208 (Metazoa), on GO:0008542
  - go_id: GO:0005513
    label: detection of calcium ion
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 94
      Invertebrates: 1
    rate_ratio: 0.0942
    p_value: 0.000907
    q_value: 0.00446
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P83094
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:15866891
      assigned_by: UniProt
      gene_review: genes/DROME/Stim/Stim-ai-review.yaml
  - go_id: GO:0140677
    label: molecular function activator activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 188
      Invertebrates: 2
    rate_ratio: 0.0942
    p_value: 7.52e-07
    q_value: 6.97e-06
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P24348
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:29358026
      assigned_by: DisProt
      gene_review: genes/worm/let-23/let-23-ai-review.yaml
    - protein: UniProtKB:Q08605
      taxon: NCBITaxon:7227
      evidence: EXP
      reference: PMID:9878427
      assigned_by: DisProt
  - go_id: GO:0097680
    label: double-strand break repair via classical nonhomologous end joining
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 93
      Invertebrates: 1
    rate_ratio: 0.0953
    p_value: 0.001
    q_value: 0.00485
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q7JKP6
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: PANTHER:PTN001809041|UniProtKB:Q12888
  - go_id: GO:0007512
    label: adult heart development
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 92
      Invertebrates: 1
    rate_ratio: 0.0963
    p_value: 0.0011
    q_value: 0.0053
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P06602
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:19233157
      assigned_by: FlyBase
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:33213 (Bilateria), on GO:0007512
  - go_id: GO:1902895
    label: positive regulation of miRNA transcription
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 275
      Invertebrates: 3
    rate_ratio: 0.0966
    p_value: 1.38e-09
    q_value: 1.85e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EFY5
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20824072
      assigned_by: UniProt
    - protein: UniProtKB:P34766
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20824072
      assigned_by: UniProt
    - protein: UniProtKB:V6CLJ5
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:20824072
      assigned_by: UniProt
      gene_review: genes/worm/lag-1/lag-1-ai-review.yaml
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe), on GO:1902895
  - go_id: GO:0045860
    label: positive regulation of protein kinase activity
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 183
      Invertebrates: 2
    rate_ratio: 0.0968
    p_value: 1.22e-06
    q_value: 1.09e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P40793
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:12490550
      assigned_by: UniProt
      gene_review: genes/DROME/Cdc42/Cdc42-ai-review.yaml
    - protein: UniProtKB:Q9VT28
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:15479641
      assigned_by: UniProt
  - go_id: GO:0032147
    label: activation of protein kinase activity
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 91
      Invertebrates: 1
    rate_ratio: 0.0974
    p_value: 0.00121
    q_value: 0.00577
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VVR2
      taxon: NCBITaxon:7227
      evidence: IDA
      reference: PMID:16890155
      assigned_by: UniProt
  - go_id: GO:0034638
    label: phosphatidylcholine catabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 91
      Invertebrates: 1
    rate_ratio: 0.0974
    p_value: 0.00121
    q_value: 0.00577
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EEM9
      taxon: NCBITaxon:6239
      evidence: IDA
      reference: PMID:23007400
      assigned_by: WB
  - go_id: GO:0070837
    label: dehydroascorbic acid transport
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 91
      Invertebrates: 1
    rate_ratio: 0.0974
    p_value: 0.00121
    q_value: 0.00577
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VU17
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: FlyBase
      with_from: UniProtKB:Q9JIF3
  - go_id: GO:0002162
    label: dystroglycan binding
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 91
      Invertebrates: 1
    rate_ratio: 0.0974
    p_value: 0.00121
    q_value: 0.00577
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:G5EG68
      taxon: NCBITaxon:6239
      evidence: IPI
      reference: PMID:17710131
      assigned_by: WB
      with_from: UniProtKB:A4VAR9
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0002162
  - go_id: GO:0071514
    label: genomic imprinting
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 91
      Invertebrates: 1
    rate_ratio: 0.0974
    p_value: 0.00121
    q_value: 0.00577
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q9VS55
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:20673338
      assigned_by: FlyBase
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:2 (Bacteria), on GO:0071514
    - never_in_taxon NCBITaxon:2157 (Archaea), on GO:0071514
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0071514
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0071514
  - go_id: GO:0042177
    label: negative regulation of protein catabolic process
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 271
      Invertebrates: 3
    rate_ratio: 0.0981
    p_value: 2.02e-09
    q_value: 2.67e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q09417
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q4ADV7
    - protein: UniProtKB:Q94361
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:19111656
      assigned_by: WB
      with_from: WB:WBGene00000839
      gene_review: genes/worm/gei-17/gei-17-ai-review.yaml
    - protein: UniProtKB:Q94361
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:19111656
      assigned_by: WB
      with_from: WB:WBGene00003955
      gene_review: genes/worm/gei-17/gei-17-ai-review.yaml
    - protein: UniProtKB:Q94361
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:19111656
      assigned_by: WB
      with_from: WB:WBGene00010890
      gene_review: genes/worm/gei-17/gei-17-ai-review.yaml
    - protein: UniProtKB:Q94361
      taxon: NCBITaxon:6239
      evidence: IGI
      reference: PMID:19111656
      assigned_by: WB
      with_from: WB:WBGene00011318
      gene_review: genes/worm/gei-17/gei-17-ai-review.yaml
    - protein: UniProtKB:Q94361
      taxon: NCBITaxon:6239
      evidence: IMP
      reference: PMID:19111656
      assigned_by: WB
      gene_review: genes/worm/gei-17/gei-17-ai-review.yaml
    - protein: UniProtKB:Q9V3C5
      taxon: NCBITaxon:7227
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q4ADV7
  - go_id: GO:0061702
    label: canonical inflammasome complex
    aspect: CC
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 90
      Invertebrates: 1
    rate_ratio: 0.0984
    p_value: 0.00134
    q_value: 0.0063
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:D0PV95
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000044
      assigned_by: UniProt
      with_from: UniProtKB-SubCell:SL-0488
    - protein: UniProtKB:D0PV95
      taxon: NCBITaxon:6239
      evidence: ISS
      reference: GO_REF:0000024
      assigned_by: UniProt
      with_from: UniProtKB:Q62167
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:131567 (cellular organisms), on GO:0061702
  - go_id: GO:0030368
    label: interleukin-17 receptor activity
    aspect: MF
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 178
      Invertebrates: 2
    rate_ratio: 0.0995
    p_value: 1.98e-06
    q_value: 1.71e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:Q10128
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107399|PANTHER:PTN001436609|UniProtKB:Q8NAC3|UniProtKB:Q96F46
    - protein: UniProtKB:Q10128
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039465
    - protein: UniProtKB:Q9NA64
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:107399|PANTHER:PTN001436609|UniProtKB:Q8NAC3|UniProtKB:Q96F46
    - protein: UniProtKB:Q9NA64
      taxon: NCBITaxon:6239
      evidence: IEA
      reference: GO_REF:0000002
      assigned_by: InterPro
      with_from: InterPro:IPR039465
    go_taxon_constraints:
    - never_in_taxon NCBITaxon:4751 (Fungi), on GO:0030368
  - go_id: GO:0003151
    label: outflow tract morphogenesis
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 267
      Invertebrates: 3
    rate_ratio: 0.0995
    p_value: 2.97e-09
    q_value: 3.8e-08
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:M9PC46
      taxon: NCBITaxon:7227
      evidence: IGI
      reference: PMID:18250318
      assigned_by: FlyBase
      with_from: FB:FBgn0005631
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0003151
    - protein: UniProtKB:P24014
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18250318
      assigned_by: FlyBase
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0003151
    - protein: UniProtKB:Q24298
      taxon: NCBITaxon:7227
      evidence: IMP
      reference: PMID:18250318
      assigned_by: FlyBase
      violates_go_taxon_constraint:
      - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0003151
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:7742 (Vertebrata), on GO:0003151
  - go_id: GO:0045663
    label: positive regulation of myoblast differentiation
    aspect: BP
    flagged_taxon: Invertebrates
    highest_taxon: Vertebrates
    annotated_protein_counts:
      Vertebrates: 178
      Invertebrates: 2
    rate_ratio: 0.0995
    p_value: 1.98e-06
    q_value: 1.71e-05
    flagged_in_2019_or_2018: false
    flagged_annotations:
    - protein: UniProtKB:P22816
      taxon: NCBITaxon:7227
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:97276|PANTHER:PTN000164853
    - protein: UniProtKB:P22980
      taxon: NCBITaxon:6239
      evidence: IBA
      reference: GO_REF:0000033
      assigned_by: GO_Central
      with_from: MGI:MGI:97276|PANTHER:PTN000164853
    go_taxon_constraints:
    - only_in_taxon NCBITaxon:6072 (Eumetazoa), on GO:0045663
  dropped:
    root_terms: 0
    root_term_flagged_annotations: 0
    root_term_flagged_nd_annotations: 0
    terms_over_max_flagged: 270
  significant_terms: 550
  candidate_terms: 280